CN112120042A - Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof - Google Patents
Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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Abstract
The invention relates to the field of disinfectant, in particular to hypochlorous acid disinfectant with high-efficiency sterilization and a preparation method thereof. The hypochlorous acid disinfectant comprises the following raw materials in percentage by weight: 5.2 to 8 weight percent of hypochlorous acid, 1 to 2.6 weight percent of sodium hypochlorite, 0.05 to 1 weight percent of sodium chloride, 0.5 to 2.4 weight percent of amino-containing compound, 2 to 7 weight percent of polyvinylpyrrolidone, 0.5 to 2.4 weight percent of hydrochloric acid with the mass fraction of 8 percent, 0.2 to 1.3 weight percent of amino acid, 0.5 to 2 weight percent of active agent and the balance of water. The hypochlorous acid disinfectant prepared by the invention has high stability and strong bactericidal property, can effectively kill various common viruses such as hand-foot-and-mouth viruses, H1N1 influenza, escherichia coli staphylococcus aureus, norovirus and the like, and has quick and efficient sterilization. The product has no harmful chemical raw materials, is mild and has no stimulation; meanwhile, the formaldehyde removing agent has the capability of removing formaldehyde. And the preparation process is simple, the practicability is strong, and the application prospect is wide.
Description
Technical Field
The invention relates to the field of disinfectant, in particular to hypochlorous acid disinfectant with high-efficiency sterilization and a preparation method thereof.
Background
The hypochlorous acid disinfectant is an aqueous solution containing stable hypochlorous acid molecules in a stock solution, and is a high-efficiency disinfectant with wide bactericidal spectrum and strong killing capacity. Hypochlorous acid, a neutral inorganic small molecule, can penetrate cell walls and cell membranes of microorganisms, destroy biological substances such as proteins and nucleic acids of the microorganisms, and cause the microorganisms to die. The using effect of the hypochlorous acid disinfectant is influenced by the content of organic matters, the concentration of the used disinfectant, the temperature, the illumination and other factors, so that more organic matters exist in a disinfection object system, and the sterilization effect is relatively reduced; the disinfectant has increased concentration and temperature, and has enhanced bactericidal effect.
The hypochlorous acid disinfectant can be widely applied to disinfection of various objects in medical and health institutions, various public places, food processing, restaurants, families and other occasions, including endoscopes and surgical instruments; sore/wound, skin mucosa; air, hands, surfaces and fabrics of objects, fruits and vegetables, tableware, secondary water supply equipment and facilities, and the like.
At present, hypochlorous acid disinfectant in the market is generally obtained by an electrolytic method or a solution method, wherein the solution method can be widely applied due to simple process. However, the solution process requires the introduction of hypochlorite, and the stability of hypochlorite is difficult to control. Factors affecting the stability of hypochlorite solutions are numerous and include mainly light, ultraviolet light and natural decomposition by high temperature. The practical effective period of the hypochlorous acid disinfectant sold in the market at present is only three to six months, so a stabilizer is usually added into the hypochlorous acid disinfectant, and although the addition of the stabilizer improves the stability of the hypochlorous acid disinfectant, the bactericidal activity of the disinfectant is also inhibited.
How to prepare the hypochlorous acid disinfectant which has both stability and sterilization performance becomes a problem to be solved urgently in the field.
Disclosure of Invention
The hypochlorous acid disinfectant with high efficiency sterilization and the preparation method thereof provided by the invention solve the defect that the stability and the sterilization effect of the conventional hypochlorous acid disinfectant cannot be compatible, and the prepared disinfectant has an excellent formaldehyde removal effect, is mild and non-irritant and can be used for sensitive skin.
The invention provides a hypochlorous acid disinfectant with high efficiency sterilization, which comprises the following raw materials in percentage by weight: 5.2 to 8 weight percent of hypochlorous acid, 1 to 2.6 weight percent of sodium hypochlorite, 0.05 to 1 weight percent of sodium chloride, 0.5 to 2.4 weight percent of amino-containing compound, 2 to 7 weight percent of polyvinylpyrrolidone, 0.5 to 2.4 weight percent of hydrochloric acid with the mass fraction of 8 percent, 0.2 to 1.3 weight percent of amino acid, 0.5 to 2 weight percent of active agent and the balance of water.
In a preferred embodiment, the amino group-containing compound is 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid.
In a preferred embodiment, the weight ratio of 3- (dodecylamino) propane-1-sulfonic acid to sulfanilic acid is 1: (0.2-0.5).
In a preferred embodiment, the viscosity of the polyvinylpyrrolidone is 2500-7000mPa.s (23 ℃).
In a preferred embodiment, the active agent is an alkyltrimethylammonium salt having from 14 to 18 carbon atoms.
In a preferred embodiment, the amino acid is at least one of lysine, arginine, histidine.
In a preferred embodiment, the weight ratio of sodium hypochlorite, amino group-containing compound and polyvinylpyrrolidone is 1: (0.7-0.92): (1.7-3.2).
The invention provides a preparation method of hypochlorous acid disinfectant with efficient sterilization, which comprises the following specific steps:
(1) adding hypochlorous acid, sodium hypochlorite, sodium chloride, an amino-containing compound, polyvinylpyrrolidone, hydrochloric acid with the mass fraction of 8%, amino acid, an active agent and water into a reaction kettle, and stirring to obtain a primary mixed solution;
(2) and (3) adjusting the pH value of the primary mixed liquid prepared in the step (1) by using an acidic substance to ensure that the pH value of the solution is 5-6.5, thus obtaining a finished product of the hypochlorous acid disinfectant.
In a preferred embodiment, the acidic substance is citric acid and/or hydrochloric acid.
In a preferred embodiment, the stirring speed of the step (1) is 30-60r/min, and the stirring time is 2-5 min.
Has the advantages that:
the hypochlorous acid disinfectant with high stability and strong sterilization performance is prepared. The acidic electrolyzed oxidizing water, slightly acidic hypochlorous acid and other products on the market at present have low stability, and the hypochlorous acid disinfectant prepared by the invention has lasting stability, can effectively kill various common viruses such as hand-foot-and-mouth viruses, H1N1 influenza, escherichia coli staphylococcus aureus, norovirus and the like, and has quick and efficient sterilization. The product has no harmful chemical raw materials, is mild and has no stimulation; meanwhile, the formaldehyde removing agent has the capability of removing formaldehyde. And the preparation process is simple, the practicability is strong, and the application prospect is wide.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definitions provided herein, the definition of the term provided herein controls.
As used herein, a feature that does not define a singular or plural form is also intended to include a plural form of the feature unless the context clearly indicates otherwise. It will be further understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "including," and/or "containing," when used in this specification means that the recited composition, step, method, article, or device is present, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or devices. Furthermore, the use of "preferred," "preferably," "more preferred," etc., when describing embodiments of the present application, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In order to solve the above problems, the invention provides a hypochlorous acid disinfectant with high efficiency sterilization, which comprises the following raw materials by weight percent: 5.2 to 8 weight percent of hypochlorous acid, 1 to 2.6 weight percent of sodium hypochlorite, 0.05 to 1 weight percent of sodium chloride, 0.5 to 2.4 weight percent of amino-containing compound, 2 to 7 weight percent of polyvinylpyrrolidone, 0.5 to 2.4 weight percent of hydrochloric acid with the mass fraction of 8 percent, 0.2 to 1.3 weight percent of amino acid, 0.5 to 2 weight percent of active agent and the balance of water.
In some preferred embodiments, the amino-containing compound is 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid. The CAS number of 3- (dodecylamino) propane-1-sulfonic acid is 1120-00-9, and the CAS number of sulfanilic acid is 121-57-3.
Further preferably, the weight ratio of the 3- (dodecylamino) propane-1-sulfonic acid to the sulfanilic acid is 1: (0.2-0.5).
The invention finds that when the compound containing amino is added, the amino compound can provide electronic groups to attract sodium hypochlorite molecules in an electron-withdrawing state in the solution, so that a relatively stable chemical structure is formed, and the self-decomposition of unstable sodium hypochlorite in the solution is inhibited. The invention discovers that when the amino-containing compound is 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid, the weight ratio of the 3- (dodecylamino) propane-1-sulfonic acid to the sulfanilic acid is 1: (0.2-0.5), the effect of improving the stability of the solution is most obvious; the specific amount of 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid are conjectured to be synergistic, so that the dispersibility of solute molecules in the system can be optimized, the uniform distribution of molecular electron cloud can be kept, the molecular activity of sodium hypochlorite can be kept, and the reduction of effective chlorine in the disinfectant under long-time scale can be inhibited.
In some preferred embodiments, the polyvinylpyrrolidone has a viscosity of 2500-.
The invention discovers that when the viscosity of the polyvinylpyrrolidone is 2500-7000mPa.s (23 ℃), the using effect of the disinfectant can be milder. The polyvinyl pyrrolidone is supposed to be polymerized by monomer vinyl pyrrolidone, and the polyvinyl pyrrolidone with the viscosity inhibits the irritation and the corrosivity of hypochlorous acid, so that the disinfectant can be even applied to disinfection of delicate skin around eyes and young children on the premise of meeting the requirement of general skin disinfection.
In some preferred embodiments, the active agent is an alkyltrimethylammonium salt having from 14 to 18 carbon atoms.
The invention discovers that when the alkyl trimethyl ammonium salt with 14-18 carbon atoms is selected as the active agent, the sterilization speed of the disinfectant can be effectively improved. The reason may be that nitrogen atoms in the alkyl trimethyl ammonium salt are directly connected with four carbon atoms through covalent bonds, so that the biological membrane protein of bacteria can be disabled, thereby inhibiting the survival of the bacteria and achieving the sterilization effect. When the number of carbon atoms is 14-18, the effect of the stabilizer is the best, and the guessing reason is that the effect of quickly changing the structure of bacteria cannot be achieved when the molecular chain is too short, so that the sterilization effect is limited; and the molecular chain is too long, so that the molecular chain of the polyvinylpyrrolidone and the alkyl trimethyl ammonium salt are easy to agglomerate, the molecular chains are easy to tangle, the stability of the system is easy to reduce, and when the carbon atom number of the alkyl trimethyl ammonium salt is 14-18, the performance of the hypochlorous acid disinfectant is optimal.
In some preferred embodiments, the amino acid is at least one of lysine, arginine, histidine.
The invention finds that when the compound containing amino also comprises amino acid, the disinfectant not only has higher stability, but also can effectively remove formaldehyde in the environment. On one hand, the amino group in the amino acid molecular structure and sodium hypochlorite molecules can form electrostatic interaction, so that the decomposition of sodium hypochlorite is inhibited; on the other hand, the amino acid has absorption capacity to light with the wavelength less than 220nm, so that the hypochlorous acid disinfectant which is easy to be photolyzed is protected, and the stability of the hypochlorous acid disinfectant is further improved. The present inventors have unexpectedly discovered that the formaldehyde removing ability of hypochlorous acid disinfectant is improved when the amino acid is at least one of lysine, tyrosine, and histidine, presumably because the amino acid can synergistically act with the strongly oxidizing hypochlorous acid molecule to chemically decompose the formaldehyde molecule in the environment, thereby effectively removing the formaldehyde.
In some preferred embodiments, the weight ratio of sodium hypochlorite, amino group-containing compound and polyvinylpyrrolidone is 1: (0.7-0.92): (1.7-3.2).
The present invention has unexpectedly found that when the weight ratio of sodium hypochlorite, amino group-containing compound, polyvinylpyrrolidone is 1: (0.7-0.92): (1.7-3.2), the prepared hypochlorous acid disinfectant has the performances of lasting stability, high sterilization speed, formaldehyde removal efficiency and the like. The reason is guessed that the system has the best compatibility of solutes such as sodium hypochlorite, 3- (dodecylamino) propane-1-sulfonic acid, sulfanilic acid and polyvinylpyrrolidone, and the components can be fully compatible, so that the defects of precipitation and flocculation easily caused by the disinfectant after long-time standing are overcome, the stability, the sterilization efficiency and the formaldehyde removal capability of the hypochlorous acid disinfectant are improved, and the reduction of the effective chlorine concentration of the disinfectant after long-time standing is inhibited.
The invention provides a preparation method of hypochlorous acid disinfectant with efficient sterilization, which comprises the following specific steps:
(1) adding hypochlorous acid, sodium hypochlorite, sodium chloride, an amino-containing compound, polyvinylpyrrolidone, hydrochloric acid with the mass fraction of 8%, amino acid, an active agent and water into a reaction kettle, and stirring to obtain a primary mixed solution;
(2) and (3) adjusting the pH value of the primary mixed liquid prepared in the step (1) by using an acidic substance to ensure that the pH value of the solution is 5-6.5, thus obtaining a finished product of the hypochlorous acid disinfectant.
In some preferred embodiments, the acidic substance is citric acid and/or hydrochloric acid.
In some preferred embodiments, the stirring speed of the step (1) is 30-60r/min, and the stirring time is 2-5 min.
Examples
Example 1.
The embodiment provides a hypochlorous acid disinfectant with high efficiency sterilization, which comprises the following raw materials in percentage by weight: 6 wt% of hypochlorous acid, 2 wt% of sodium hypochlorite, 0.5 wt% of sodium chloride, 1.6 wt% of amino-containing compound, 6 wt% of polyvinylpyrrolidone, 1.6 wt% of hydrochloric acid with the mass fraction of 8%, 1 wt% of amino acid, 1.2 wt% of active agent and the balance of water.
The amino-containing compound is 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid, the CAS number of the 3- (dodecylamino) propane-1-sulfonic acid is 1120-00-9, and the CAS number of the sulfanilic acid is 121-57-3.
The weight ratio of the 3- (dodecyl amino) propane-1-sulfonic acid to the sulfanilic acid is 1: 0.5.
the polyvinylpyrrolidone has a viscosity of 2500mPa.s (23 ℃), and is purchased from Shanghai Kauchi Fine chemical Co., Ltd., and the model is Luvitec K80.
The active agent is cetyltrimethylammonium chloride, purchased from sigma aldrich trade ltd, CAS No. 112-02-7.
The amino acid is lysine, purchased from sigma aldrich (shanghai) trade, ltd, CAS number 56-87-1.
The preparation method of the high-efficiency sterilized hypochlorous acid disinfectant comprises the following specific steps:
(1) adding hypochlorous acid, sodium hypochlorite, sodium chloride, an amino-containing compound, polyvinylpyrrolidone, hydrochloric acid with the mass fraction of 8%, amino acid, an active agent and water into a reaction kettle, and stirring to obtain a primary mixed solution;
(2) and (3) adjusting the pH value of the primary mixed liquid prepared in the step (1) by using an acidic substance to ensure that the pH value of the solution is 6, thus obtaining a hypochlorous acid disinfectant finished product.
The acidic substance is citric acid.
The stirring speed of the stirring in the step (1) is 40r/min, and the stirring time is 3 min.
Comparative example 1.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. The difference is that the weight ratio of the 3- (dodecyl amino) propane-1-sulfonic acid to the sulfanilic acid is 1: 1.
comparative example 2.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. Except that the amino group containing compound was replaced with sodium dodecylbenzene sulfonate purchased from sigma aldrich (shanghai) trade company, CAS No. 25155-30-0.
Comparative example 3.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. The difference is that the viscosity of the polyvinylpyrrolidone is 140mPa.s (23 ℃), and the polyvinylpyrrolidone is purchased from Shanghai Hopkinson Fine chemical Co., Ltd., and the model is Luvitec K30.
Comparative example 4.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. The difference is that the activator is replaced by dodecyl trimethyl ammonium chloride, which is purchased from Wenchuan Chang trade company, Guangzhou, under the CAS number of 112-00-5.
Comparative example 5.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. The difference is that the activator is replaced by octyl dodecyl dimethyl ammonium chloride, which is purchased from Shandong Jining Hongyun chemical Co., Ltd, and has a CAS number of 10361-16-7.
Comparative example 6.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. The difference is that the amino acid is replaced with tryptophan, which is purchased from Sigma Aldrich trade company, Inc. under CAS number 73-22-3.
Comparative example 7.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. Except that no amino acid was added.
Comparative example 8.
The specific implementation mode of the hypochlorous acid disinfectant with high-efficiency sterilization is the same as that of the example 1. Except that the amino group-containing compound was added in an amount of 0.6 wt%.
Performance test method
Stability of hypochlorous acid disinfectant:
and (3) detecting according to a stability detection method in GB/T2738-2012 daily chemical product antibacterial and bacteriostatic effect evaluation. The hypochlorous acid disinfectant sample is placed in a brown glass bottle, sealed and stored for 90 days in a thermostat at 37 ℃, samples are taken periodically, the available chlorine content in the hypochlorous acid disinfectant sample bottle is measured by an iodometry method, and the stability of the hypochlorous acid disinfectant is evaluated by the reduction rate of the available chlorine content of the hypochlorous acid disinfectant.
The stability acceleration experiment is carried out on the hypochlorous acid disinfectant prepared in the embodiment according to the 'disinfection technical specification 2002 edition', wherein the hypochlorous acid disinfectant is stored at the constant temperature and humidity of 54 ℃ for 14 days, the available chlorine is reduced by less than or equal to 10 percent, and the effective period reaches 1 year; the product is preserved at 37 ℃ under constant temperature and humidity for 90 days, the available chlorine is reduced by less than or equal to 10 percent, and the validity period reaches 2 years.
And (3) testing the sterilization efficiency:
the method comprises the steps of adding calf serum with volume fraction of 50% into bacillus subtilis black variant spore suspension to prepare a bacterial carrier, using the hypochlorous acid disinfectant prepared by the embodiment of the invention to act on the bacterial carrier for a certain time, and calculating the time required when the sterilization rate is more than or equal to 99%.
The formaldehyde clearance rate:
an experimental device is built according to the national standard QB-T2761-2006 method for measuring the purification effect of indoor air purification products, and the hypochlorous acid disinfectant prepared by the embodiment is used for experimental testing. After 24h, the formaldehyde concentration (mg/cubic meter) in each sample chamber is respectively measured, and the formaldehyde clearance rate is calculated, wherein the clearance rate is regulated to be superior when the clearance rate is more than 90 percent, the clearance rate is good when the clearance rate is between 80 and 90 percent, and the clearance rate is poor when the clearance rate is less than 80 percent. The initial concentration in each sample chamber was 5mg/mm3。
Performance test data
TABLE 1 results of Performance test of examples and comparative examples
| The reduction rate of available chlorine content% | Time to sterilize/min | Formaldehyde scavenging effect | |
| Example 1 | 6.30 | 1 | Superior food |
| Comparative example 1 | 12.60 | 1 | Good wine |
| Comparative example 2 | 17.10 | 1 | Good wine |
| Comparative example 3 | 10.20 | 3 | Good wine |
| Comparative example 4 | 11.50 | 5 | Good wine |
| Comparative example 5 | 14.80 | 7 | Superior food |
| Comparative example 6 | 9.20 | 3 | Good wine |
| Comparative example 7 | 12.70 | 4 | Difference (D) |
| Comparative example 8 | 16.40 | 3 | Good wine |
From the results of the performance tests of the examples and comparative examples, it can be seen that when 1 part by weight of: (0.2-0.5) 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid, the stability of the hypochlorous acid disinfectant is obviously improved; when the activator selects alkyl trimethyl ammonium salt with 14-18 carbon atoms, the hypochlorous acid disinfectant has high sterilization speed and high efficiency; by controlling the weight ratio of the sodium hypochlorite to the amino-containing compound to the polyvinylpyrrolidone, the viscosity of the polyvinylpyrrolidone and the specific type of the amino acid in the system, the hypochlorous acid disinfectant has the excellent performance of removing formaldehyde while having the advantages of lasting stability, high-efficiency sterilization.
Finally, it should be understood that the above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The hypochlorous acid disinfectant with high efficiency sterilization is characterized by comprising the following raw materials in percentage by weight: 5.2 to 8 weight percent of hypochlorous acid, 1 to 2.6 weight percent of sodium hypochlorite, 0.05 to 1 weight percent of sodium chloride, 0.5 to 2.4 weight percent of amino-containing compound, 2 to 7 weight percent of polyvinylpyrrolidone, 0.5 to 2.4 weight percent of hydrochloric acid with the mass fraction of 8 percent, 0.2 to 1.3 weight percent of amino acid, 0.5 to 2 weight percent of active agent and the balance of water.
2. The hypochlorous acid disinfectant with high sterilizing efficiency as claimed in claim 1, wherein said amino group containing compounds are 3- (dodecylamino) propane-1-sulfonic acid and sulfanilic acid.
3. The hypochlorous acid disinfectant with high sterilizing efficiency as claimed in claim 2, wherein the weight ratio of 3- (dodecylamino) propane-1-sulfonic acid to sulfanilic acid is 1: (0.2-0.5).
4. The hypochlorous acid disinfectant as claimed in claim 3, wherein the viscosity of polyvinylpyrrolidone is 2500-7000 mPa.s.
5. The hypochlorous acid disinfectant with high sterilizing efficiency as claimed in claim 1, wherein said activator is alkyl trimethyl ammonium salt with 14-18 carbon atoms.
6. The hypochlorous acid disinfectant with high sterilizing efficiency as claimed in claim 1, wherein said amino acid is at least one of lysine, arginine and histidine.
7. The highly effective disinfectant hypochlorous acid liquid as claimed in claim 4, wherein the weight ratio of sodium hypochlorite, amino group containing compound and polyvinylpyrrolidone is 1: (0.7-0.92): (1.7-3.2).
8. The preparation method of the hypochlorous acid disinfectant for efficient sterilization according to any one of claims 1 to 7, which comprises the following specific steps:
(1) adding hypochlorous acid, sodium hypochlorite, sodium chloride, an amino-containing compound, polyvinylpyrrolidone, hydrochloric acid with the mass fraction of 8%, amino acid, an active agent and water into a reaction kettle, and stirring to obtain a primary mixed solution;
(2) and (3) adjusting the pH value of the primary mixed liquid prepared in the step (1) by using an acidic substance to ensure that the pH value of the solution is 5-6.5, thus obtaining a finished product of the hypochlorous acid disinfectant.
9. The method for preparing hypochlorous acid disinfectant with high sterilizing efficiency as claimed in claim 8, wherein said acidic substance is citric acid and/or hydrochloric acid.
10. The method for preparing hypochlorous acid disinfectant with high efficiency sterilization as claimed in claim 8, wherein the stirring speed in step (1) is 30-60r/min, and the stirring time is 2-5 min.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113209212A (en) * | 2021-04-26 | 2021-08-06 | 贵州扬生医用器材有限公司 | Hand disinfectant and preparation method thereof |
| CN113876891A (en) * | 2021-11-03 | 2022-01-04 | 山东康克尔医疗器械有限公司 | Pharmaceutical composition for oral care and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113209212A (en) * | 2021-04-26 | 2021-08-06 | 贵州扬生医用器材有限公司 | Hand disinfectant and preparation method thereof |
| CN113876891A (en) * | 2021-11-03 | 2022-01-04 | 山东康克尔医疗器械有限公司 | Pharmaceutical composition for oral care and preparation method thereof |
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Application publication date: 20201225 |