CN111700822A - Skin disinfectant and preparation method thereof - Google Patents
Skin disinfectant and preparation method thereof Download PDFInfo
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- CN111700822A CN111700822A CN202010718389.9A CN202010718389A CN111700822A CN 111700822 A CN111700822 A CN 111700822A CN 202010718389 A CN202010718389 A CN 202010718389A CN 111700822 A CN111700822 A CN 111700822A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention belongs to the technical field of disinfectants, and particularly relates to a skin disinfectant and a preparation method thereof. The disinfectant comprises components such as ethanol, hydrogen peroxide, a stabilizer, a synergist and the like, and the ethanol, the hydrogen peroxide and the synergist can synergistically improve the sterilization effect on staphylococcus aureus, candida albicans and escherichia coli, so that the sterilization effect is strong; the inorganic phosphate or organic phosphate stabilizer can reduce the reduction of effective content of hydrogen peroxide caused by the degradation of external factors and obviously improve the stability of the hydrogen peroxide; the disinfectant has the advantages of no toxicity, no odor, low irritation, etc., and is suitable for disinfecting and cleaning skin surface.
Description
Technical Field
The invention belongs to the technical field of disinfectants. More particularly, it relates to a skin disinfectant and a preparation method thereof.
Background
Along with the gradual improvement of the life quality of people, healthy and safe disinfection products and composite antibacterial and bacteriostatic products are developed rapidly. Currently, commercially available disinfectants mainly include the following types: phenols, alcohols, aldehydes, chlorine-containing disinfectants, quaternary ammonium salts, iodine and the like. For skin surface disinfection, alcohol disinfectant, iodine tincture disinfectant and hydrogen peroxide disinfectant are generally adopted. Wherein, the effective component ethanol of the alcohol disinfectant is easy to volatilize, and the effective content is reduced quickly, so that the alcohol disinfectant needs more usage amount when in use; the characteristic color of the iodine tincture skin disinfectant after use is limited in an environmental place, so that the iodine tincture skin disinfectant is not recommended to be used in a public place; hydrogen peroxide skin disinfectants have an irritating odor that is intolerable to humans.
In order to solve various defects of active ingredients in single use, multiple reagents with disinfection efficacy are often combined in the prior art to achieve the effect of low-concentration efficient sterilization, for example, chinese patent application CN102696674A discloses a low-concentration hydrogen peroxide disinfectant, which is prepared from hydrogen peroxide, alkyl dimethyl amine oxide, a metal ion complexing agent, ethanol, glycerol, an inorganic acid and water, and has the effects of rapid sterilization and stable property; chinese patent application CN101766183A discloses a sanitary disinfectant, which is prepared from chlorhexidine, sodium carboxymethylcellulose, chloramine-based sodium toluenesulfonate, hydrogen peroxide and ethanol, and has good bactericidal effect and low production cost. However, both of the two disinfectant solutions contain hydrogen peroxide (hydrogen peroxide), which is very unstable and can be rapidly decomposed in the presence of metal ions, impurities, heat and other factors, so that the effective content is reduced, and effective sterilization cannot be achieved; and the hydrogen peroxide has stronger oxidizability, can cause the oxidation of metal containers and technical devices in the preparation and storage processes, and seriously limits the application of the hydrogen peroxide.
Therefore, it is urgently needed to provide a skin disinfectant which has good stability, is compatible with metal, has broad-spectrum efficient sterilization and long-acting bacteriostasis.
Disclosure of Invention
The invention aims to solve the technical problems of overcoming the defects and the defects of poor stability, limited disinfection effect of single active ingredients and the like of the existing hydrogen peroxide disinfectant and providing the skin disinfectant which has good stability, is compatible with metal, has broad-spectrum efficient sterilization and long-acting bacteriostasis.
The invention aims to provide a skin disinfectant.
The invention also aims to provide a preparation method of the disinfectant for skin.
The above purpose of the invention is realized by the following technical scheme:
the skin disinfectant is prepared from the following components in percentage by weight:
30-80 vol% of ethanol, 1-3 wt% of hydrogen peroxide, 0.02-0.1 wt% of a stabilizer, 0-0.5 wt% of a forming agent, 0.1-1 wt% of a synergist, 0-0.2 wt% of a pH regulator and the balance of water;
wherein the stabilizer is inorganic phosphate or organic phosphate.
In practice, the inventor finds that when the disinfectant solution of about 30 vol% of ethanol and about 2 wt% of hydrogen peroxide is separately adopted for carrying out a microbe killing test, the killing logarithm value of the two disinfectant solutions is less than 1 (the killing rate is less than 90%), and the killing logarithm value of the microbe killing test of the two mixed disinfectant solutions is more than 3, which indicates that the ethanol and the hydrogen peroxide have good sterilization synergistic performance, and the principle should be as follows: the hydrogen peroxide is subjected to heterolysis to generate molecular oxygen, which permeates into bacteria (viruses) to generate a de-electron reaction on proteins and generates a high-efficiency synergistic effect with the denaturation of ethanol molecules on the proteins, so that the protein denaturation and death processes of the bacteria (viruses) are greatly accelerated, the time is shortened, and the efficiency is greatly improved.
However, it was found that hydrogen peroxide, an active ingredient thereof, has poor stability when used, and is rapidly decomposed in the presence of metal ions, impurities, heat, etc., thereby significantly reducing the effective content and reducing the sterilization effect. The inventor finds that the stability of the effective component hydrogen peroxide can be obviously improved and the degradation caused by the external influence can be reduced by adding inorganic phosphate or organic phosphate into the disinfectant through a great deal of creative research.
Preferably, the skin disinfectant is prepared from the following components in percentage by weight:
40-80 vol% of ethanol, 1-2 wt% of hydrogen peroxide, 0.02-0.5 wt% of a stabilizer, 0-0.4 wt% of a forming agent, 0.5-1 wt% of a synergist, 0-0.2 wt% of a pH regulator and the balance of water.
More preferably, the skin disinfectant is prepared from the following components in percentage by weight:
60 vol% of ethanol, 1 wt% of hydrogen peroxide, 0.02 wt% of stabilizer, 0.36 wt% of forming agent, 0.5 wt% of synergist, 0.2 wt% of pH regulator and the balance of water.
Further, the inorganic phosphate includes phosphate, metaphosphate, pyrophosphate.
Still further, the organophosphates include hydroxyethylidene diphosphonate (HEDP), aminotrimethylene phosphonic Acid (ATMP).
Further, the synergist is azone.
Further, the azone is water soluble azone or oil soluble azone.
The azone can effectively promote the perforation, irregular breakage and content expansion of the cell wall of the bacteria (virus) and promote the death of the bacteria (virus). The inventor finds that the sterilization effect of the disinfectant can be obviously improved by compounding ethanol, hydrogen peroxide and azone, and the quantitative killing test of the suspension of staphylococcus aureus, candida albicans and escherichia coli in 1min meets the killing log value of the disinfectant being more than 5.
Further, the forming agent is polyacrylic acid, polyacrylate salt or cellulose thickening agent.
Still further, the pH adjuster is citric acid, sodium hydroxide, phosphoric acid, or triethanolamine.
The skin disinfectant can be prepared into liquid spray, gel and other dosage forms, and is used for disinfecting human skin, animal skin and the like in hospitals, civilian use and public places.
In addition, the invention also provides a preparation method of the disinfectant for skin, which comprises the following steps:
adding the stabilizer into water, stirring for dissolving, adding ethanol, hydrogen peroxide, forming agent and synergist, stirring and mixing to be uniform, and adjusting pH to obtain the final product.
Further, the pH value is adjusted to be 3-7.
The invention has the following beneficial effects:
the skin disinfectant disclosed by the invention comprises the components of ethanol, hydrogen peroxide, a stabilizer, a synergist and the like, and the ethanol, the hydrogen peroxide and the synergist can synergistically improve the sterilization effect on staphylococcus aureus, candida albicans and escherichia coli, so that the sterilization effect is strong; the inorganic phosphate or organic phosphate stabilizer can reduce the effective content reduction of the hydrogen peroxide caused by external factors and obviously improve the stability of the hydrogen peroxide; the disinfectant has the advantages of no toxicity, no odor, low irritation, etc., and is suitable for disinfecting and cleaning skin surface.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
Examples 1 to 6 skin disinfectant
The skin disinfectant is prepared from the following components:
table 1 examples 1-6 skin disinfectant compositions and mass percent (wt%)
The preparation method comprises the following steps:
adding the stabilizer into water, stirring and dissolving, adding ethanol, hydrogen peroxide, a forming agent and a synergist, stirring and mixing for 1-2 hours until the mixture is uniform, and adjusting the pH to 3-7 by using a pH regulator to obtain the composite stabilizer.
Comparative examples 1 to 5A disinfectant for skin
The skin disinfectant is prepared from the following components:
table 2 comparative examples 1 to 5 components and mass% (% by weight) of skin disinfectant
The preparation method comprises the following steps:
and (3) mixing the raw materials, stirring and mixing for 1-2 hours until the mixture is uniform, and thus obtaining the composite material.
Experimental example 1 skin disinfectant Performance test
1. The sterilization detection was performed according to the detection method of the relevant items of the quantitative killing test of the suspension in 2002 "Disinfection technical Specification".
Wherein the killing log value of staphylococcus aureus and escherichia coli is more than 5, and the killing log value of candida albicans is more than 5, so that the requirements of the disinfectant are met. The higher the killing logarithm value is, the stronger the sterilization performance is; in the killing test, the shortest time for the disinfectant to kill the logarithm value is set, and the shorter the time is, the faster the sterilization effect is.
2. And (3) stability testing: after the drying oven with the temperature of 54 ℃ for 14 days is adopted, the effective content of the hydrogen peroxide is detected, and the index that the effective content is reduced by 10 percent is met and is qualified.
The test results are shown in Table 3.
Table 3 skin disinfectant performance test results
The table shows that the skin disinfectants of the embodiments 1-6 of the invention meet the requirements of skin disinfectants with ethanol 30% (v/v) \\ hydrogen peroxide 1 wt% and above, and the killing performance aiming at common three types of bacteria (viruses) meets the requirement of 2002 disinfection technical specification; the action time is 0.5-1 min, and the disinfectant belongs to a quick disinfectant. And the comparative examples 1-2 adopt the ethanol or the hydrogen peroxide disinfectant alone, so that the sterilization effect is unqualified, and the sterilization effect time of the hydrogen peroxide is longer. In the comparative examples 3-4, the effective content of hydrogen peroxide is reduced by more than 10% in the accelerated test process without adding a stabilizer, so that the stability requirement of the disinfectant is not met; compared with the comparative examples 3 and 5, no synergist is added, the sterilization effect is obviously reduced within 1min of action time, and the requirements of 2002 sterilization technical specifications on the microbial killing performance (the killing logarithm value is more than 5) of the disinfectant are not met.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. The skin disinfectant is characterized by being prepared from the following components in percentage by weight:
30-80 vol% of ethanol, 1-3 wt% of hydrogen peroxide, 0.02-0.1 wt% of a stabilizer, 0-0.5 wt% of a forming agent, 0.1-1 wt% of a synergist, 0-0.2 wt% of a pH regulator and the balance of water;
wherein the stabilizer is inorganic phosphate or organic phosphate.
2. The skin disinfectant according to claim 1, wherein the skin disinfectant is prepared from the following components in percentage by weight:
40-80 vol% of ethanol, 1-2 wt% of hydrogen peroxide, 0.02-0.5 wt% of a stabilizer, 0-0.4 wt% of a forming agent, 0.5-1 wt% of a synergist, 0-0.2 wt% of a pH regulator and the balance of water.
3. The skin disinfectant according to claim 2, wherein the skin disinfectant is prepared from the following components in percentage by weight:
60 vol% of ethanol, 1 wt% of hydrogen peroxide, 0.02 wt% of stabilizer, 0.36 wt% of forming agent, 0.5 wt% of synergist, 0.2 wt% of pH regulator and the balance of water.
4. The disinfectant for skin as set forth in any one of claims 1 to 3, wherein the inorganic phosphate comprises phosphate, metaphosphate and pyrophosphate.
5. The skin disinfectant according to any one of claims 1 to 3, wherein said organophosphate comprises hydroxyethylidene diphosphonic acid or aminotrimethylene phosphonic acid.
6. The skin disinfectant according to any one of claims 1 to 3, wherein said synergist is azone.
7. The disinfectant for skin as set forth in claim 6, wherein said azone is water-soluble azone or oil-soluble azone.
8. The skin disinfectant according to any one of claims 1 to 3, wherein the forming agent is polyacrylic acid, polyacrylate salt, or cellulose thickener.
9. The skin disinfectant according to any one of claims 1 to 3, wherein the pH adjuster is citric acid, sodium hydroxide, phosphoric acid, or triethanolamine.
10. A method of preparing a disinfectant for skin as claimed in any one of claims 1 to 9, comprising the steps of:
adding the stabilizer into water, stirring for dissolving, adding ethanol, hydrogen peroxide, forming agent and synergist, stirring and mixing to be uniform, and adjusting pH to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010718389.9A CN111700822A (en) | 2020-07-23 | 2020-07-23 | Skin disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010718389.9A CN111700822A (en) | 2020-07-23 | 2020-07-23 | Skin disinfectant and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112913840A (en) * | 2021-01-06 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Ultralow-temperature peracetic acid disinfectant and preparation method thereof |
| CN112932995A (en) * | 2021-02-05 | 2021-06-11 | 天天向上(宁波)医疗科技有限公司 | Surface cleaning wiping towel and production method thereof |
| CN113398047A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Hydrogen peroxide-containing hand disinfectant and preparation method thereof |
| CN113575610A (en) * | 2021-08-25 | 2021-11-02 | 四川恒通动保生物科技有限公司 | Low-temperature-resistant hydrogen peroxide disinfectant and preparation method thereof |
| CN113801028A (en) * | 2021-10-15 | 2021-12-17 | 成都科宏达科技有限公司 | Special surfactant for hydrogen peroxide and compound thereof |
| CN113966741A (en) * | 2021-12-10 | 2022-01-25 | 西安文理学院 | Efficient and environment-friendly bactericide |
| CN114467971A (en) * | 2020-11-11 | 2022-05-13 | 上海利康消毒高科技有限公司 | Hydrogen peroxide disinfectant and preparation method thereof |
| CN114747568A (en) * | 2022-04-27 | 2022-07-15 | 山东利尔康医疗科技股份有限公司 | Medium-level disinfection wet tissue and preparation method thereof |
| CN116098163A (en) * | 2022-12-01 | 2023-05-12 | 湖北怡和亚太卫生用品有限公司 | Method for preparing hydrogen peroxide disinfectant and application thereof |
| CN116195594A (en) * | 2022-12-30 | 2023-06-02 | 广东红日星实业有限公司 | Disinfection cleaning agent and preparation method and application thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114467971A (en) * | 2020-11-11 | 2022-05-13 | 上海利康消毒高科技有限公司 | Hydrogen peroxide disinfectant and preparation method thereof |
| CN112913840A (en) * | 2021-01-06 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Ultralow-temperature peracetic acid disinfectant and preparation method thereof |
| CN112932995A (en) * | 2021-02-05 | 2021-06-11 | 天天向上(宁波)医疗科技有限公司 | Surface cleaning wiping towel and production method thereof |
| CN113398047A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Hydrogen peroxide-containing hand disinfectant and preparation method thereof |
| CN113575610A (en) * | 2021-08-25 | 2021-11-02 | 四川恒通动保生物科技有限公司 | Low-temperature-resistant hydrogen peroxide disinfectant and preparation method thereof |
| CN113801028A (en) * | 2021-10-15 | 2021-12-17 | 成都科宏达科技有限公司 | Special surfactant for hydrogen peroxide and compound thereof |
| CN113801028B (en) * | 2021-10-15 | 2023-11-10 | 成都科宏达科技有限公司 | Special surfactant for hydrogen peroxide and compound thereof |
| CN113966741A (en) * | 2021-12-10 | 2022-01-25 | 西安文理学院 | Efficient and environment-friendly bactericide |
| CN114747568A (en) * | 2022-04-27 | 2022-07-15 | 山东利尔康医疗科技股份有限公司 | Medium-level disinfection wet tissue and preparation method thereof |
| CN116098163A (en) * | 2022-12-01 | 2023-05-12 | 湖北怡和亚太卫生用品有限公司 | Method for preparing hydrogen peroxide disinfectant and application thereof |
| CN116195594A (en) * | 2022-12-30 | 2023-06-02 | 广东红日星实业有限公司 | Disinfection cleaning agent and preparation method and application thereof |
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Application publication date: 20200925 |