CN111374130A - Compound double-chain quaternary ammonium salt disinfectant for livestock and poultry and preparation method thereof - Google Patents
Compound double-chain quaternary ammonium salt disinfectant for livestock and poultry and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
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- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
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Abstract
The invention relates to the technical field of disinfection, in particular to a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry and a preparation method thereof. The preparation raw materials at least comprise the following components in parts by weight: 5-20 parts of double-chain quaternary ammonium salt, 15-40 parts of aldehyde compound, 0.01-0.1 part of inorganic acid, 6-17 parts of surfactant, 0.1-1 part of essence and 60-85 parts of micromolecular alcohol. Through the synergistic effect of various components, the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry has the advantages of broad spectrum, high efficiency, low toxicity and long-term storage.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry and a preparation method thereof.
Background
With the rapid development of intensive breeding industry, the disinfectant is used for disinfecting livestock and the surrounding environment to kill pathogens and cut off the infection path, and the disinfectant becomes an important measure for preventing and controlling the epidemic of the livestock and poultry infectious diseases.
Under the current trend of higher and higher intensification degree, diseases of the breeding farm are more and more complicated, and the problem of animal epidemic disease prevention and treatment is very prominent. The occurrence of epidemic diseases in large-scale farms is often the result of a multi-factor combination effect, but the most important of the epidemic diseases is caused by invasion and diffusion of pathogenic microorganisms in the external environment or pollution and diffusion of pathogenic microorganisms of animals in the farms. Effective disinfection is one of important measures for stopping and reducing pathogens in the environment of a farm, cutting off epidemic disease transmission ways and preventing and controlling infectious diseases of the farm. However, the disinfectants commonly used at present, such as bleaching powder, sodium hypochlorite, peroxide, phenols, formaldehyde and the like, have common defects, such as poor stability, strong corrosivity, strong irritation and the like, and some disinfectants are harmful to human bodies and even have carcinogenic effect.
Therefore, the development of low-toxicity and high-efficiency compound disinfectants is a necessary development trend.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry, which comprises the following preparation raw materials in parts by weight: 5-20 parts of double-chain quaternary ammonium salt, 15-40 parts of aldehyde compound, 0.01-0.1 part of inorganic acid, 6-17 parts of surfactant, 0.1-1 part of essence and 60-85 parts of micromolecular alcohol.
As a preferable technical solution of the present invention, the double-chain quaternary ammonium salt is selected from one or more of didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, dioctadecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium bromide, didecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium bromide, and dioctadecyl dimethyl ammonium bromide.
As a preferable technical scheme of the invention, the double-chain quaternary ammonium salt is didecyl dimethyl ammonium chloride.
In a preferred embodiment of the present invention, the aldehyde compound is one or more selected from glutaraldehyde, glyoxal, and o-phthalaldehyde.
In a preferred embodiment of the present invention, the inorganic acid is one or more selected from carbonic acid, phosphoric acid, and boric acid.
In a preferred embodiment of the present invention, the surfactant is an amphoteric surfactant.
As a preferable technical scheme of the invention, the amphoteric surfactant is selected from one or more of dodecyl ethoxy sulfobetaine, dodecyl hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine, tetradecylamidopropyl hydroxypropyl sulfobetaine and decyl dimethyl hydroxypropyl sulfobetaine.
As a preferable technical scheme of the invention, the amphoteric surfactant is dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: (1-3.2).
As a preferable technical scheme of the invention, the small molecule alcohol is selected from one or more of methanol, ethanol, n-propanol, isopropanol, n-butanol and isobutanol.
The second aspect of the invention provides a preparation method of a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry, which comprises the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
Has the advantages that: the invention provides a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry and a preparation method thereof, wherein double-chain quaternary ammonium salt and glutaraldehyde are compounded for use, and the proportion between the double-chain quaternary ammonium salt and the glutaraldehyde is reasonably regulated, so that the defects that the glutaraldehyde is stable and has weak sterilization capability under an acidic condition are overcome, and the problem that mycoplasma and spores cannot be killed due to narrow sterilization spectrum of the quaternary ammonium salt is solved; in addition, according to the characteristics of the double-chain quaternary ammonium salt, the existence stability and the dispersibility of the double-chain quaternary ammonium salt in a system are improved by utilizing the synergistic effect among a plurality of amphoteric surfactants; the water-soluble essence, particularly the lemon-flavored essence, is added, so that the pungent smell of glutaraldehyde can be relieved, and the sterilization effect can be further realized; through the synergistic effect of various components, the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry has the advantages of broad spectrum, high efficiency, low toxicity and long-term storage.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the first aspect of the invention provides a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry, which comprises the following raw materials in parts by weight: 5-20 parts of double-chain quaternary ammonium salt, 15-40 parts of aldehyde compound, 0.01-0.1 part of inorganic acid, 6-17 parts of surfactant, 0.1-1 part of essence and 60-85 parts of micromolecular alcohol.
In a more preferred embodiment, the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is prepared from at least the following raw materials in parts by weight: 10-15 parts of double-chain quaternary ammonium salt, 20-35 parts of aldehyde compound, 0.01-0.05 part of inorganic acid, 10-15 parts of surfactant, 0.3-0.7 part of essence and 65-75 parts of micromolecular alcohol.
In a most preferred embodiment, the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is prepared from the following raw materials in parts by weight: 12 parts of double-chain quaternary ammonium salt, 30 parts of aldehyde compound, 0.01 part of inorganic acid, 13 parts of surfactant, 0.5 part of essence and 70 parts of small molecular alcohol.
Double-chain quaternary ammonium salt
In a preferred embodiment, the double-chain quaternary ammonium salt is selected from one or more of didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, dioctadecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium bromide, didecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium bromide, and dioctadecyl dimethyl ammonium bromide.
In a most preferred embodiment, the double-stranded quaternary ammonium salt is didecyldimethylammonium chloride.
The preparation method of the didecyl dimethyl ammonium chloride comprises the following steps:
(1) adding dodecatetradecyl dimethyl tertiary amine into a reaction kettle, starting stirring, adding benzyl chloride into the reaction kettle, and sealing a feeding port, wherein the mass ratio of the dodecatetradecyl dimethyl tertiary amine to the benzyl chloride is (1-3.5): 1;
(2) slowly heating, stopping heating when the temperature of the raw materials in the kettle reaches 25-40 ℃, and continuously stirring;
(3) after 5-10min, when the temperature in the kettle is high, starting cooling water, and controlling the temperature to be 70-80 ℃;
(4) continuously stirring at 70-80 deg.C for 50-70min when the temperature tends to be stable.
In a preferred embodiment, the method for preparing didecyldimethylammonium chloride comprises the following steps:
(1) adding dodecatetradecyl dimethyl tertiary amine into a reaction kettle, starting stirring, adding benzyl chloride into the reaction kettle, and sealing a feeding port, wherein the mass ratio of the dodecatetradecyl dimethyl tertiary amine to the benzyl chloride is 1.85: 1;
(2) slowly heating, stopping heating when the temperature of the raw materials in the kettle reaches 30 ℃, and continuously stirring;
(3) after 8min, when the temperature in the kettle is high, starting cooling water, and controlling the temperature to be 75 ℃;
(4) and (3) continuously stirring for 60min at the temperature of 75 ℃ when the temperature tends to be stable, thus obtaining the product.
Aldehyde compound
In a preferred embodiment, the aldehyde compound is selected from one or more of glutaraldehyde, glyoxal, o-phthalaldehyde.
In a most preferred embodiment, the aldehyde compound is glutaraldehyde.
The glutaraldehyde high-efficiency disinfectant has the characteristics of broad spectrum, high efficiency, low toxicity, small corrosion to metal, small influence by organic matters, good stability and the like. Is suitable for disinfection and sterilization of medical instruments and moisture-proof and heat-proof precise instruments. The killing effect of the glutaraldehyde on the microorganisms mainly depends on aldehyde groups, and the glutaraldehyde mainly acts on sulfhydryl groups, hydroxyl groups, carboxyl groups and amino groups of mycoprotein, can be alkylated to cause protein solidification to cause bacterial death, belongs to a broad-spectrum and high-efficiency disinfectant, and can kill all microorganisms, but the glutaraldehyde has long sterilization time which is generally 10 hours, so that the glutaraldehyde needs to be compounded with double-chain quaternary ammonium salt to improve the sterilization efficiency, and particularly, the glutaraldehyde is compounded with didecyldimethylammonium chloride to achieve the best synergistic effect.
Inorganic acid
The inorganic acid is a general term for acids of inorganic compounds, and the inorganic acid is a compound consisting of hydrogen and nonmetallic elements and mainly used for providing hydrogen ions.
In a preferred embodiment, the inorganic acid is selected from one or more of carbonic acid, phosphoric acid, boric acid.
In a most preferred embodiment, the inorganic acid is phosphoric acid.
The phosphoric acid or orthophosphoric acid of the invention is of the formula H3PO4Molecular weight is 97.994, a common mineral acid, which is a medium strong acid. Is prepared by dissolving phosphorus pentoxide in hot water. Orthophosphoric acid is industrially obtained by treating apatite with sulfuric acid. Phosphoric acid is easily deliquesced in air. Upon heating, water is lost to give pyrophosphoric acid, which is further dehydrated to give metaphosphoric acid.
Surface active agent
The surfactant is a substance which is added in a small amount and can cause the interface state of a solution system of the surfactant to change obviously. Has fixed hydrophilic and lipophilic groups and can be directionally arranged on the surface of the solution. The molecular structure of the surfactant has amphipathy, one end of the surfactant is a hydrophilic group, and the other end of the surfactant is a hydrophobic group; the hydrophilic group is often a polar group, such as carboxylic acid, sulfonic acid, sulfuric acid, amino or amino groups and salts thereof, hydroxyl, amide, ether linkages, and the like may also be used as the polar hydrophilic group; and the hydrophobic group is often a non-polar hydrocarbon chain, such as a hydrocarbon chain of 8 or more carbon atoms.
In a preferred embodiment, the surfactant is an amphoteric surfactant.
The amphoteric surfactant of the present invention is a surfactant containing both an anionic hydrophilic group and a cationic hydrophilic group in the same molecule. The biggest characteristic is that it can give out proton and accept proton. The bactericidal and mildew-inhibiting agent has certain bactericidal and mildew-inhibiting properties, and also has good emulsifying and dispersing properties.
In a more preferred embodiment, the amphoteric surfactant is selected from one or more of dodecyl ethoxy sulphobetaine, dodecyl hydroxypropyl sulphobetaine, dodecyl sulphopropyl betaine, tetradecanamidopropyl hydroxypropyl sulphobetaine, decyl dimethyl hydroxypropyl sulphobetaine.
In a more preferred embodiment, the amphoteric surfactants of the present invention are dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of dodecyl ethoxy sulfobetaine to dodecyl sulfopropyl betaine is 1: (1-3.2).
In a most preferred embodiment, the amphoteric surfactants of the present invention are dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of dodecyl ethoxy sulfobetaine to dodecyl sulfopropyl betaine is 1: 2.6.
the inventor finds in experiments that the amphoteric surfactant is added into a double-chain quaternary ammonium salt system, so that not only can the dispersing capacity of the double-chain quaternary ammonium salt in a solution be enhanced, the stability of the double-chain quaternary ammonium salt be improved, but also a synergistic effect can be generated with the double-chain quaternary ammonium salt, so that the sterilizing and disinfecting capacity of the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is further enhanced, particularly, the invention selects the compounding of dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, and when the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: (1-3.2), the effect is best; the possible reasons are that the dodecyl sulfobetaine has quaternary ammonium salt cations and sulfonic anions, shows excellent surface performance, has excellent water resistance, good calcium soap dispersibility and low irritation, has an obvious synergistic effect when being compounded with dodecyl ethoxy sulfobetaine, is non-toxic, has small irritation, is easy to dissolve in water, is stable to acid and alkali, has excellent bactericidal property, can stably exist with cationic surfactant double-chain quaternary ammonium salt, and further increases the stability and the disinfection capacity of the double-chain quaternary ammonium salt.
Essence
In a preferred embodiment, the perfume of the present invention is a water-soluble perfume.
In a preferred embodiment, the water-soluble essence of the invention is selected from one or more of rose water-soluble essence, jasmine water-soluble essence, clove water-soluble essence, orange water-soluble essence, gardenia water-soluble essence, lavender water-soluble essence and lemon water-soluble essence.
In a most preferred embodiment, the water-soluble fragrance of the present invention is a lemon water-soluble fragrance.
According to the invention, the lemon water-soluble essence is adopted, so that on one hand, the irritating taste of glutaraldehyde can be further slowed down; on the other hand, the lemon has fragrant smell and has the functions of sterilization and antivirus.
Small molecule alcohol
In a preferred embodiment, the small molecule alcohol is selected from one or more of methanol, ethanol, n-propanol, isopropanol, n-butanol and isobutanol.
In a most preferred embodiment, the small molecule alcohol of the present invention is ethanol.
The ethanol is flammable and volatile colorless transparent liquid at normal temperature and normal pressure, has low toxicity, and can not be directly drunk as pure liquid; has special fragrance and slight irritation; slightly sweet and accompanied by pungent and spicy taste. Inflammable, its vapor can form explosive mixture with air, and it can be dissolved in water in any ratio.
According to the invention, ethanol is used as a solvent, so that on one hand, the solubility of the double-chain quaternary ammonium salt, glutaraldehyde, essence and surfactant can be effectively increased; on the other hand, the disinfectant also has a bactericidal effect, and has a synergistic effect with the double-chain quaternary ammonium salt, the glutaraldehyde and the amphoteric surfactant, so that the bactericidal capability of the disinfectant is effectively enhanced.
The second aspect of the invention provides a preparation method of a compound double-chain quaternary ammonium salt disinfectant for livestock and poultry, which at least comprises the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1
The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is provided, and the preparation raw materials comprise the following components in parts by weight: 12 parts of double-chain quaternary ammonium salt, 30 parts of aldehyde compound, 0.01 part of inorganic acid, 13 parts of surfactant, 0.5 part of essence and 70 parts of small molecular alcohol.
The double-chain quaternary ammonium salt is didecyl dimethyl ammonium chloride.
The preparation method of the didecyl dimethyl ammonium chloride comprises the following steps:
(1) adding dodecatetradecyl dimethyl tertiary amine into a reaction kettle, starting stirring, adding benzyl chloride into the reaction kettle, and sealing a feeding port, wherein the mass ratio of the dodecatetradecyl dimethyl tertiary amine to the benzyl chloride is 1.85: 1;
(2) slowly heating, stopping heating when the temperature of the raw materials in the kettle reaches 30 ℃, and continuously stirring;
(3) after 8min, when the temperature in the kettle is high, starting cooling water, and controlling the temperature to be 75 ℃;
(4) and (3) continuously stirring for 60min at the temperature of 75 ℃ when the temperature tends to be stable, thus obtaining the product.
The aldehyde compound is glutaraldehyde.
The inorganic acid is phosphoric acid.
The surfactant is an amphoteric surfactant.
The amphoteric surfactant is dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: 2.6.
the essence is water-soluble essence.
The water-soluble essence is lemon water-soluble essence.
The small molecular alcohol is ethanol.
The preparation method of the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry comprises the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
Example 2
The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is provided, and the preparation raw materials comprise the following components in parts by weight: 5 parts of double-chain quaternary ammonium salt, 15 parts of aldehyde compound, 0.01 part of inorganic acid, 6 parts of surfactant, 0.1 part of essence and 60 parts of small molecular alcohol.
The double-chain quaternary ammonium salt is didecyl dimethyl ammonium chloride.
The preparation method of the didecyl dimethyl ammonium chloride comprises the following steps:
(1) adding dodecatetradecyl dimethyl tertiary amine into a reaction kettle, starting stirring, adding benzyl chloride into the reaction kettle, and sealing a feeding port, wherein the mass ratio of the dodecatetradecyl dimethyl tertiary amine to the benzyl chloride is 1.85: 1;
(2) slowly heating, stopping heating when the temperature of the raw materials in the kettle reaches 30 ℃, and continuously stirring;
(3) after 8min, when the temperature in the kettle is high, starting cooling water, and controlling the temperature to be 75 ℃;
(4) and (3) continuously stirring for 60min at the temperature of 75 ℃ when the temperature tends to be stable, thus obtaining the product.
The aldehyde compound is glutaraldehyde.
The inorganic acid is phosphoric acid.
The surfactant is an amphoteric surfactant.
The amphoteric surfactant is dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: 2.6.
the essence is water-soluble essence.
The water-soluble essence is lemon water-soluble essence.
The small molecular alcohol is ethanol.
The preparation method of the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry comprises the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
Example 3
The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is provided, and the preparation raw materials comprise the following components in parts by weight: 20 parts of double-chain quaternary ammonium salt, 40 parts of aldehyde compound, 0.1 part of inorganic acid, 17 parts of surfactant, 1 part of essence and 85 parts of micromolecular alcohol.
The double-chain quaternary ammonium salt is didecyl dimethyl ammonium chloride.
The preparation method of the didecyl dimethyl ammonium chloride comprises the following steps:
(1) adding dodecatetradecyl dimethyl tertiary amine into a reaction kettle, starting stirring, adding benzyl chloride into the reaction kettle, and sealing a feeding port, wherein the mass ratio of the dodecatetradecyl dimethyl tertiary amine to the benzyl chloride is 1.85: 1;
(2) slowly heating, stopping heating when the temperature of the raw materials in the kettle reaches 30 ℃, and continuously stirring;
(3) after 8min, when the temperature in the kettle is high, starting cooling water, and controlling the temperature to be 75 ℃;
(4) and (3) continuously stirring for 60min at the temperature of 75 ℃ when the temperature tends to be stable, thus obtaining the product.
The aldehyde compound is glutaraldehyde.
The inorganic acid is phosphoric acid.
The surfactant is an amphoteric surfactant.
The amphoteric surfactant is dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, wherein the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: 2.6.
the essence is water-soluble essence.
The water-soluble essence is lemon water-soluble essence.
The small molecular alcohol is ethanol.
The preparation method of the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry comprises the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
Example 4
Similar to example 1, except that the amphoteric surfactant is dodecyl ethoxy sulfobetaine.
Example 5
Similar to example 1, except that the amphoteric surfactant was dodecylsulfopropyl betaine.
Example 6
Similar to example 1, except that the starting materials were free of aldehydes.
Example 7
Similar to example 1, except that no double-chain quaternary ammonium salt was present in the starting material.
Example 8
Similar to example 1, except that the double-stranded quaternary ammonium salt is dioctadecyldimethylammonium bromide.
Evaluation of Performance
1. Sterilization and disinfection Capacity test
The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry provided by the embodiments 1 to 8 is subjected to a carrier soaking quantitative sterilization test, and experimental bacteria are respectively staphylococcus aureus (ATCC6538), escherichia coli (8099) and candida albicans (ATCC 10231). The formulated solutions obtained in examples 1-8 were each added to a sterile plate in an amount of 5.0mL for one pellet. Preheating for 5min on a water bath at the temperature of 19-21 ℃, and then adding the bacterial tablets. After a certain time of action, the bacterial slices are moved into a test tube filled with 5.0mL of neutralizer, and the neutralization action is carried out for 10 min. The tube was tapped 80 times to elute the pellet and mixed well. 5.0mL of eluent is taken as viable bacteria for counting, and the killing rate is calculated. The results obtained are shown in table 1.
TABLE 1 results of bactericidal power test
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. A compound double-chain quaternary ammonium salt disinfectant for livestock and poultry is characterized by comprising the following preparation raw materials in parts by weight: 5-20 parts of double-chain quaternary ammonium salt, 15-40 parts of aldehyde compound, 0.01-0.1 part of inorganic acid, 6-17 parts of surfactant, 0.1-1 part of essence and 60-85 parts of micromolecular alcohol.
2. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 1, wherein the double-chain quaternary ammonium salt is selected from one or more of didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, dioctadecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium bromide and dioctadecyl dimethyl ammonium bromide.
3. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 2, wherein the double-chain quaternary ammonium salt is didecyl dimethyl ammonium chloride.
4. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 1, wherein the aldehyde compound is one or more selected from glutaraldehyde, glyoxal and o-phthalaldehyde.
5. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 1, wherein the inorganic acid is selected from one or more of carbonic acid, phosphoric acid and boric acid.
6. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 1, wherein the surfactant is an amphoteric surfactant.
7. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 6, wherein the amphoteric surfactant is selected from one or more of dodecyl ethoxy sulfobetaine, dodecyl hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine, tetradecylamidopropyl hydroxypropyl sulfobetaine and decyl dimethyl hydroxypropyl sulfobetaine.
8. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 6, wherein the amphoteric surfactants are dodecyl ethoxy sulfobetaine and dodecyl sulfopropyl betaine, and the mass ratio of the dodecyl ethoxy sulfobetaine to the dodecyl sulfopropyl betaine is 1: (1-3.2).
9. The compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to claim 1, wherein the small molecular alcohol is selected from one or more of methanol, ethanol, n-propanol, isopropanol, n-butanol and isobutanol.
10. The preparation method of the compound double-chain quaternary ammonium salt disinfectant for livestock and poultry according to any one of claims 1 to 9, characterized by comprising the following steps: dissolving the double-chain quaternary ammonium salt, the aldehyde compound, the inorganic acid, the surfactant and the essence in the small molecular alcohol, and uniformly stirring to obtain the product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114145294A (en) * | 2021-10-15 | 2022-03-08 | 成都科宏达科技有限公司 | Composite disinfectant containing alpha-alkyl betaine and application thereof |
| CN115119848A (en) * | 2021-10-19 | 2022-09-30 | 湖南坤源生物科技有限公司 | Disinfectant for livestock and poultry and preparation method thereof |
-
2020
- 2020-04-07 CN CN202010265660.8A patent/CN111374130A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114145294A (en) * | 2021-10-15 | 2022-03-08 | 成都科宏达科技有限公司 | Composite disinfectant containing alpha-alkyl betaine and application thereof |
| CN115119848A (en) * | 2021-10-19 | 2022-09-30 | 湖南坤源生物科技有限公司 | Disinfectant for livestock and poultry and preparation method thereof |
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