CN102696674A - Low-concentration hydrogen peroxide disinfectant and preparation method thereof - Google Patents
Low-concentration hydrogen peroxide disinfectant and preparation method thereof Download PDFInfo
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- CN102696674A CN102696674A CN2012101816817A CN201210181681A CN102696674A CN 102696674 A CN102696674 A CN 102696674A CN 2012101816817 A CN2012101816817 A CN 2012101816817A CN 201210181681 A CN201210181681 A CN 201210181681A CN 102696674 A CN102696674 A CN 102696674A
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Abstract
The invention relates to a low-concentration hydrogen peroxide disinfectant and a preparation method thereof. The low-concentration hydrogen peroxide disinfectant comprises the following components in percentage by weight (wt %): 0.1-1 percent of hydrogen peroxide, 0.05-0.5 percent of akyl dimethyl amine oxide, 0.01-0.1 percent of metal ion complexing agent, 1-10 percent of ethanol, 0.5-3 percent of glycerol, 0.01-0.05 percent of inorganic acid and the balance of water. The preparation method of the low-concentration hydrogen peroxide disinfectant comprises the following steps of: adding the metal ion complexing agent into the water according to the content and the component and stirring to dissolve; adding the akyl dimethyl amine oxide, the ethanol and the glycerol in sequence and stirring to dissolve; adding the hydrogen peroxide and stirring to uniformly mix; and then adding the inorganic acid, stirring to dissolve and uniformly mixing to obtain the low-concentration hydrogen peroxide disinfectant. The low-concentration hydrogen peroxide disinfectant has the advantages of simple preparation process, stable character and quick sterilization effect.
Description
Technical field
The present invention relates to thimerosal, relate in particular to disinfectant with hydrogen peroxide liquid and preparation method thereof.
Background technology
Aqueous hydrogen peroxide solution is claimed hydrogen peroxide solution again, is the liquid that two hydrogen atoms and two oxygen atoms are arranged in a kind of each molecule, has stronger permeability and oxidation, in water, can form very strong free hydroxyl of oxidability and reactive derivative.In its decomposable process, discharge unusual active nascent oxygen [O], can make cells of microorganisms film and protoplasm shattered to pieces and reach the purpose of deactivation.Hydrogen peroxide has very strong oxidability; Fungicidal spectrum is wide; Can effectively kill various bacterial propagules, fungi, tubercle bacillus and various virus, be commonly used to clean wound and local antibacterial, also can be used for the sterilization of tableware, clothes, drinking-water, contact lenses and heat labile plastic products.
The advantage of hydrogen peroxide is very remarkable, promptly finally resolves into the oxygen G&W, and environment is not formed pollution, is a kind of environment-friendly type disinfectant.The shortcoming of hydrogen peroxide also clearly, pure hydrogen peroxide is very stable, but the low concentration stability of peroxide is very poor, and concentration is low more, stability of peroxide is poor more, bactericidal potency more a little less than.CN101032254A and CN101053330A have reported respectively and have improved the technology of stability of peroxide and sterilizing ability, but only the higher relatively hydrogen peroxide of concentration studied.
In the daily use, the case that the hydrogenperoxide steam generator of useful 3% concentration uses after with 1:2 ratio dilute with water, but for family expenses, not only trouble but also low precision.
Summary of the invention
The present invention is intended to overcome the shortcoming that the low concentration stability of peroxide is poor, sterilizing power is weak, and a kind of low concentration disinfectant with hydrogen peroxide liquid and preparation method thereof is provided.The preparation technology of low concentration disinfectant with hydrogen peroxide liquid of the present invention is simple, and product property is stable, and bactericidal action is quick.
The present invention is achieved in that
A kind of low concentration disinfectant with hydrogen peroxide liquid, it comprises each component of following each percetage by weight:
Hydrogen peroxide, 0.1-1;
Alkyl dimethyl amine oxide, 0.05-0.5;
The complexing of metal ion agent, 0.01-0.1;
Ethanol, 1-10;
Glycerine, 0.5-3;
Inorganic acid, 0.01-0.05;
Water, surplus.
Described thimerosal, the carbochain of alkyl is C described in the said alkyl dimethyl amine oxide molecule
12-C
18
Described thimerosal, said complexing of metal ion agent is disodium ethylene diamine tetraacetate or benzotriazole.
Described thimerosal, said inorganic acid are phosphoric acid or boric acid.
The preparation method of described thimerosal is: by said content and component, the complexing of metal ion agent is added to the water stirring and dissolving; Add alkyl dimethyl amine oxide, ethanol, glycerine successively, stirring and dissolving; Add hydrogen peroxide, mix; Add inorganic acid again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
The present invention adopts alkyl dimethyl amine oxide and ethanol to strengthen the bactericidal property of low concentration hydrogen peroxide.Alkyl dimethyl amine oxide is a kind of cationic surfactant, can promote contacting of hydrogen peroxide and microorganism negative cells wall.Ethanol is a kind of micromolecular compound, has short osmosis, can help hydrogen peroxide to penetrate in the microbial body.The present invention adopts the complexing of metal ion agent to get rid of the interference of metal ion, adopts inorganic acid to keep acid ph value, and both act synergistically and help to improve the low concentration stability of peroxide.The present invention utilizes the skin moisten moisture-keeping function of glycerine, alleviates the excitant of hydrogen peroxide, improves the comfortableness that product uses.
Embodiment
Below, in conjunction with specific embodiment, further specify the present invention:
A kind of low concentration disinfectant with hydrogen peroxide liquid, it comprises each component of following each percetage by weight:
Hydrogen peroxide, 0.1-1;
Alkyl dimethyl amine oxide, 0.05-0.5;
The complexing of metal ion agent, 0.01-0.1;
Ethanol, 1-10;
Glycerine, 0.5-3;
Inorganic acid, 0.01-0.05;
Water, surplus.
Described thimerosal, alkyl carbon chain is C12-C18 in the molecule of said alkyl dimethyl amine oxide.
Described thimerosal is characterized in that, said complexing of metal ion agent is disodium ethylene diamine tetraacetate or benzotriazole.
Described thimerosal, said inorganic acid are phosphoric acid or boric acid.
The preparation method of described thimerosal is: by said content and component, the complexing of metal ion agent is added to the water stirring and dissolving; Add alkyl dimethyl amine oxide, ethanol, glycerine successively, stirring and dissolving; Add hydrogen peroxide, mix; Add inorganic acid again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
Embodiment 1
Disodium ethylene diamine tetraacetate 0.5 gram is joined in the 887.4 gram water stirring and dissolving; Add DDAO 1 gram, ethanol 100 grams, glycerine 10 grams successively, stirring and dissolving; Add hydrogen peroxide 1 gram, mix; Add phosphoric acid 0.1 gram again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
Embodiment 2
Benzotriazole 1 gram is joined in the 923.7 gram water stirring and dissolving; Add cetyl dimethyl amine oxide 5 grams, ethanol 30 grams, glycerine 30 grams successively, stirring and dissolving; Add hydrogen peroxide 10 grams, mix; Add phosphoric acid 0.3 gram again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
Embodiment 3
Disodium ethylene diamine tetraacetate 0.3 gram is joined in the 937.5 gram water stirring and dissolving; Add octadecyl dimethyl amine oxide 2 grams, ethanol 50 grams, glycerine 5 grams successively, stirring and dissolving; Add hydrogen peroxide 5 grams, mix; Add boric acid 0.2 gram again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
Embodiment 4
Benzotriazole 0.5 gram is joined in the 958 gram water stirring and dissolving; Add CH3-(CH2)13N(CH3)2-O 3 grams, ethanol 10 grams, glycerine 20 grams successively, stirring and dissolving; Add hydrogen peroxide 8 grams, mix; Add boric acid 0.5 gram again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
Get above-mentioned each embodiment; Adopt carrier quantitative germicidal test; Under 19-21 ℃ of condition, it is equal that effect 1min on average kills logarithm value to staphylococcus aureus>5.0, it is equal that effect 1min on average kills logarithm value to Escherichia coli>5.0; It is equal that effect 1min on average kills logarithm value to pseudomonas aeruginosa>5.0, it is equal that effect 1min on average kills logarithm value to Candida albicans>4.0.
Get above-mentioned each embodiment, adopt 37 ℃ of accelerated stability tests of depositing 3 months, active o content rate of descent equal < 10%.
Get above-mentioned each embodiment, do rabbit intact skin irritant test and a skin injury irritant test, result of the test all shows rabbit skin nonirritant.
Like the low concentration disinfectant with hydrogen peroxide liquid that above-mentioned embodiment makes, product property is stable, and bactericidal effect is good, and is non-stimulated to skin.
Claims (3)
1. a low concentration disinfectant with hydrogen peroxide liquid is characterized in that, it comprises each component of following each percetage by weight:
Hydrogen peroxide, 0.1-1;
Alkyl dimethyl amine oxide, 0.05-0.5;
Complexing of metal ion agent: disodium ethylene diamine tetraacetate or benzotriazole, 0.01-0.1;
Ethanol, 1-10;
Glycerine, 0.5-3;
Inorganic acid: phosphoric acid or boric acid, 0.01-0.05;
Water, surplus.
2. thimerosal according to claim 1 is characterized in that, alkyl carbon chain is C in the molecule of said alkyl dimethyl amine oxide
12-C
18
3. the preparation method of a low concentration disinfectant with hydrogen peroxide liquid according to claim 1 and 2 is: by said content and component, the complexing of metal ion agent is added to the water stirring and dissolving; Add alkyl dimethyl amine oxide, ethanol, glycerine successively, stirring and dissolving; Add hydrogen peroxide, mix; Add inorganic acid again, stirring and dissolving mixes, and promptly gets described low concentration disinfectant with hydrogen peroxide liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101816817A CN102696674A (en) | 2012-06-05 | 2012-06-05 | Low-concentration hydrogen peroxide disinfectant and preparation method thereof |
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| CN2012101816817A CN102696674A (en) | 2012-06-05 | 2012-06-05 | Low-concentration hydrogen peroxide disinfectant and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734153A (en) * | 2014-01-20 | 2014-04-23 | 王德昌 | Water-soluble biological insecticide containing active abamectin and preparation method of biological insecticide |
| CN103891767A (en) * | 2012-12-31 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Bleaching disinfectant |
| CN111264555A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Hydrogen peroxide disinfectant and preparation method and application thereof |
| CN111388339A (en) * | 2020-03-27 | 2020-07-10 | 陈乐� | Novel quick washing-free disinfectant |
| CN111450114A (en) * | 2020-05-21 | 2020-07-28 | 苏州汇涵医用科技发展有限公司 | Compound disinfectant liquid containing hydrogen peroxide and silver ions and preparation method thereof |
| CN111700822A (en) * | 2020-07-23 | 2020-09-25 | 广州泰晟生物科技股份有限公司 | Skin disinfectant and preparation method thereof |
| CN113398047A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Hydrogen peroxide-containing hand disinfectant and preparation method thereof |
| CN116509895A (en) * | 2023-07-04 | 2023-08-01 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
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| CN1104424A (en) * | 1993-07-16 | 1995-07-05 | 伊斯曼柯达公司 | Hydrogen peroxide composition |
| CN1379983A (en) * | 2001-04-13 | 2002-11-20 | 郭颖 | Compound disinfectant liquor and its preparation method |
| CN101484564A (en) * | 2006-07-06 | 2009-07-15 | 森特尼尔投资有限公司 | Broad spectrum and skin friendly disinfecting composition |
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| CN1104424A (en) * | 1993-07-16 | 1995-07-05 | 伊斯曼柯达公司 | Hydrogen peroxide composition |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103891767A (en) * | 2012-12-31 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Bleaching disinfectant |
| CN103734153A (en) * | 2014-01-20 | 2014-04-23 | 王德昌 | Water-soluble biological insecticide containing active abamectin and preparation method of biological insecticide |
| CN103734153B (en) * | 2014-01-20 | 2016-04-27 | 王德昌 | A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof |
| CN111264555A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Hydrogen peroxide disinfectant and preparation method and application thereof |
| CN111388339A (en) * | 2020-03-27 | 2020-07-10 | 陈乐� | Novel quick washing-free disinfectant |
| CN111450114A (en) * | 2020-05-21 | 2020-07-28 | 苏州汇涵医用科技发展有限公司 | Compound disinfectant liquid containing hydrogen peroxide and silver ions and preparation method thereof |
| CN111700822A (en) * | 2020-07-23 | 2020-09-25 | 广州泰晟生物科技股份有限公司 | Skin disinfectant and preparation method thereof |
| CN113398047A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Hydrogen peroxide-containing hand disinfectant and preparation method thereof |
| CN116509895A (en) * | 2023-07-04 | 2023-08-01 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
| CN116509895B (en) * | 2023-07-04 | 2023-09-12 | 山东利尔康医疗科技股份有限公司 | Low-concentration peracetic acid hand disinfectant and preparation method thereof |
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Application publication date: 20121003 |
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