CN114190371A - Ultralow-temperature peroxyacetic acid disinfectant - Google Patents
Ultralow-temperature peroxyacetic acid disinfectant Download PDFInfo
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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Abstract
The invention relates to the technical field of sanitation and disinfection, and discloses an ultralow-temperature peracetic acid disinfectant, which comprises a low-temperature disinfection compound auxiliary agent and peracetic acid; the content of the peroxyacetic acid is 0.1-1.5 wt% based on the total weight of the ultralow-temperature peroxyacetic acid disinfectant; the low-temperature disinfection compound additive comprises 10-60 wt% of water, 40-70 wt% of antifreeze, 0-1 wt% of odor masking agent, 0.01-8% of synergist, 0-5% of corrosion inhibitor and 0.01-5% of stabilizer; the synergist is selected from the combination of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone and azone and PEG/PPG copolymer. The ultra-low temperature peroxyacetic acid disinfectant can be used for cold chain links and low temperature environments, and particularly can be used for disinfection in the fields of medicines, chemical engineering, special food raw materials and the like at the low temperature of below 25 ℃ below zero, even below 30 ℃ below zero.
Description
Technical Field
The invention relates to the technical field of sanitation and disinfection, and particularly discloses an ultralow-temperature peroxyacetic acid disinfectant.
Background
The peroxyacetic acid is a mixture of peroxyacetic acid and acetic anhydride, is a strong oxidant, has oxidation effect when meeting with the release of nascent oxygen from organic matters, is a common disinfection and sterilization medicine, has a far stronger disinfection effect than common acid and peroxide, has high-efficiency killing effect on bacteria, spores, fungi and viruses, and is used for disinfecting skin, instruments, air and the like.
A large amount of repeated daily cold chain products are disinfected, and a disinfectant with effective disinfection effect at low temperature, good stability and high activity is needed. At present, the actual disinfection is generally directly carried out by adopting a normal-temperature disinfectant, the disinfection activity is low at low temperature, even the activity is lost, the disinfection effect cannot be achieved, and the risk of continuous virus propagation exists. The prior art document 1CN100382703C discloses a compound peroxy acid disinfectant and a processing technology thereof, which is characterized in that a surfactant and an organic solvent are added into a mixed solution of hydrogen peroxide, acetic acid and sulfuric acid, octanoic acid is emulsified in the mixed solution to form microemulsion, and the microemulsion is stirred at room temperature to prepare the compound peroxy acid disinfectant containing peroxyacetic acid, peroxyoctanoic acid and hydrogen peroxide, the disinfectant has good disinfection and sterilization effects, stable performance, low corrosivity, no residue, no toxicity, safety and reliability, and can maintain excellent sterilization performance at a low temperature of-20 ℃; low raw material cost, simple process, convenient operation and easy industrialized production.
However, the compound peroxyacid disinfectant in the prior art document 1CN100382703C can only be used at the temperature of-20 ℃, and if the compound peroxyacid disinfectant is used at a lower temperature, the sterilizing effect is obviously reduced. Therefore, there is a need for a peracetic acid disinfectant that can be used at ultra-low temperatures (-30 ℃) and that can maintain excellent germicidal properties.
In the prior art, a synergist is usually added for better effect of the peroxyacetic acid disinfectant.
Prior art document 2CN101803612A discloses a compound low-corrosiveness high-efficiency biochemical disinfectant, which is composed of the following substances by mass percent: an oxidation main agent A10-80% and a synergistic additive B20-90%; the oxidation main agent A is solid peroxide, and the synergistic auxiliary agent B comprises an activating agent containing an amido group or an ester group; the main oxidation agent A and the synergistic additive B in the disinfectant are packaged in a binary mode. The solid peroxide is selected from at least one of the following: sodium percarbonate, sodium perborate, urea peroxide, perphosphates and persilicates; preferably sodium percarbonate and more preferably encapsulated sodium percarbonate. The synergistic assistant B is 20-95% of an activating agent containing an amido group or an ester group, 0-50% of a buffering agent, 0-10% of a surfactant, 0-10% of a corrosion inhibitor and 0-10% of a stabilizer. Before use, the oxidation main agent and the synergistic auxiliary agent are prepared into an aqueous solution with the mass concentration of 0.1-10% according to a proportion for disinfection. The disinfectant can efficiently disinfect various pathogenic pathogens such as viruses, bacteria, spores and the like, has good disinfection effect on toxic and harmful substances such as organic phosphorus, sulfur and the like, chemical reagents and the like, and simultaneously has good storage stability, low corrosivity on the surface of disinfection equipment, safety for personnel and no pollution to the environment.
The prior art document 3CN1689410A discloses a high-efficiency composite iodine disinfectant with strong permeability, which is prepared from the following components in parts by weight: 3-15% of PVP; 0.2 to 0.8 percent of iodine; 0.10-0.30% of citric acid; SDS, 0.10-0.30%; peroxyacetic acid, 0.005-0.04%; deionized water and the balance; wherein citric acid is used as a stabilizing agent, SDS is used as a synergist, and peroxyacetic acid is used as an activator.
Although the above prior art documents 2 and 3 disclose some synergists which can be used in combination with peracetic acid, these synergists can be used only at normal temperature, and if they are used at ultra-low temperature (-30 ℃), the synergistic effect is lost and good bactericidal performance cannot be achieved.
In addition, many containers, transportation vehicles and the like in the cold chain transportation process are made of metal materials such as stainless steel, carbon steel, copper, aluminum and the like, and when repeated, large-scale and daily disinfection is carried out by using low-temperature peracetic acid, attention needs to be paid to the fact that the materials cannot be corroded, and the service life of the containers, the transportation vehicles and the like is affected.
Based on the defects in the prior art, the invention provides an ultralow-temperature peracetic acid disinfectant, which can have a good disinfection effect at-30 ℃; furthermore, the ultralow-temperature peracetic acid disinfectant provided by the invention has low corrosivity on metal materials, and can ensure the service life of the metal materials.
Disclosure of Invention
The invention relates to an ultralow-temperature peracetic acid disinfectant, which solves the problems that the current low-temperature disinfection is lack of available products, the disinfectant has great irritation to workers, and the disinfection effect is poor due to low activity of a common disinfectant at low temperature, and can be used for disinfection in various links of a cold chain and various low-temperature environments, in particular to the disinfection in the low-temperature field below-30 ℃ such as medicines, chemical engineering and special food raw materials.
The invention relates to an ultralow temperature peroxyacetic acid disinfectant, which can be applied to ultralow temperature disinfection below-30 ℃.
The ultralow-temperature peroxyacetic acid disinfectant comprises a low-temperature disinfection compound auxiliary agent and peroxyacetic acid; the content of the peroxyacetic acid is 0.1 to 1.5 weight percent based on the total weight of the ultralow-temperature peroxyacetic acid disinfectant;
the low-temperature disinfection compound additive comprises 10-60 wt% of water, 40-70 wt% of antifreezing agent, 0-5 wt% of odor masking agent, 0.01-8 wt% of synergist, 0-5 wt% of corrosion inhibitor and 0.01-5 wt% of stabilizer;
the synergist is selected from the combination of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone and azone and PEG/PPG copolymer.
Preferably, the anti-freezing agent is an organic solvent; preferably, the solvent is a combination of one or more of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, hexylene glycol, diethylene glycol, methanol, triethylene glycol, and a monoalkyl ether of diethylene glycol.
Preferably, the odor masking agent is selected from propylene glycol alginate.
Preferably, the corrosion inhibitor in the ultralow temperature peracetic acid disinfectant comprises the following raw materials in percentage by weight: 5 to 30 weight percent of phytic acid, 10 to 30 weight percent of pentaerythritol, 5 to 20 weight percent of benzotriazole and 10 to 40 weight percent of siloxane.
The stabilizer in the ultralow-temperature peroxyacetic acid disinfectant comprises the following raw materials in percentage by weight: 0.1 to 1.5 weight percent of ethylenediamine tetramethylene phosphonic acid, 0.1 to 3 weight percent of polyhydric alcohol phosphate, 0 to 1 weight percent of ethyl acetate, 0 to 1 weight percent of ethanol and 0 to 3 weight percent of acetic acid.
In another aspect, the present invention also relates to a synergist for use in an ultra-low temperature peroxyacetic acid disinfectant, said synergist being selected from the group consisting of polyethylene glycol 200, polyethylene glycol 400, thiazone, azone in combination with a PEG/PPG copolymer.
Preferably, the content of the PEG/PPG copolymer is 20 wt% to 60 wt% based on the total weight of the synergist.
Preferably, the PEG/PPG copolymer is preferably a PEG/PPG-17/6 copolymer, which is a random community of 17 moles of ethylene oxide and 6 moles of propylene on average, interacting with each other.
The invention also discloses a preparation method of the ultralow temperature peroxyacetic acid disinfectant, wherein high-concentration liquid peroxyacetic acid and the multifunctional composite low-temperature solvent are respectively prepared, and the preparation steps of the multifunctional composite low-temperature solvent are as follows:
s1, quantitatively weighing water, adding the water into a stirring vessel, quantitatively weighing the water-soluble corrosion inhibitor, adding the water-soluble corrosion inhibitor, and stirring until the water-soluble corrosion inhibitor is dissolved;
s2 quantitatively weighing the odor masking agent, adding the odor masking agent into the S1 product, and heating for dissolving;
s3, quantitatively weighing the organic antifreezing agent, adding the quantitatively weighed alcohol-soluble raw material, and stirring until the alcohol-soluble raw material is dissolved;
s4, stirring and mixing the S2 and the S3 products uniformly, filtering and filling.
In another aspect, the present invention also relates to the use of the above synergist for peracetic acid disinfectants to be added to disinfectants comprising peracetic acid, such that the peracetic acid disinfectant still maintains good disinfecting activity at a temperature of-30 ℃.
The invention has the beneficial effects that:
(1) the ultra-low temperature peroxyacetic acid disinfectant of the invention can be prepared into low temperature disinfectants with different freezing points and disinfection capacities by mixing the low temperature disinfection compound auxiliary agent and peroxyacetic acid in any proportion. Wherein, the antifreezing agent with different amount is added into the raw material of the low-temperature disinfection compound auxiliary agent, so that the system can be used at different low temperatures. The invention solves the problems that the prior low-temperature disinfection is lack of available products, the worker resistance is caused by great irritation of the disinfectant, the disinfection effect is poor caused by low activity of the common disinfectant at low temperature and the like, and can be used for various links of a cold chain and various low-temperature environments, in particular to disinfection in the low-temperature field of below-25 ℃, even below-30 ℃ of medicines, chemical engineering, special food raw materials and the like;
(2) the synergist of the invention can ensure that the peroxyacetic acid disinfectant still keeps good antivirus activity at the temperature below 20 ℃ below zero, even below 30 ℃ below zero, because the micromolecule synergist such as the glycol 200, the azone, the thiaketone and the like can promote the effective components to enter the cells through the surface layer by influencing the surface layer of the bacterial body so as to promote the effective components of the disinfectant to enter the microbial structure to play a role, meanwhile, compared with polyethylene glycol 200, the PEG/PPG copolymer is unfavorable for free radical transfer and has a free radical quenching effect compared with micromolecules such as thiaketone and the like, the PEG/PPG copolymer greatly reduces the adverse effect of free radicals generated by the decomposition of the synergist with a conjugated structure such as the thiaketone and the like under the illumination on the stability of the peroxyacetic acid, meanwhile, the spraying uniformity of the disinfectant at low temperature can be improved, the disinfection qualified rate is improved, and the killing effect is further improved compared with the conventional technology;
(3) the special corrosion inhibitor formula is added into the peracetic acid disinfectant, so that the corrosion effect on a disinfection object material is reduced, wherein stainless steel is basically free of corrosion, carbon steel is basically free of corrosion, copper and aluminum are slightly corroded, the service life of a metal material is prolonged, the irritation of the disinfectant is reduced, and the peracetic acid disinfectant can be used for disinfecting in cold chain links and in low-temperature environments;
(4) the odor masking agent adopted by the invention has the functions of adsorbing and slowly releasing the peroxyacetic acid, and the odor masking agent and the stabilizing agent are combined to further improve the stability of the peroxyacetic acid, greatly reduce the reduction rate and improve the long-acting killing effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The invention relates to an ultralow-temperature peroxyacetic acid disinfectant, which is prepared by mixing a low-temperature disinfection compound auxiliary agent and peroxyacetic acid in any proportion. The peroxyacetic acid is a commercially available peroxyacetic acid solution of any concentration.
In some embodiments, the binary product of the high-concentration liquid peroxyacetic acid and the low-temperature disinfection compound auxiliary agent is directly matched for use, the low-temperature disinfection can be performed only by adding the amount of the peroxyacetic acid required by the target concentration into the compound synergistic antifreezing agent and uniformly mixing, complex preparation is not needed, and the use is convenient and safe. The high-concentration liquid peroxyacetic acid is prepared by quantitatively subpackaging a commercial peroxyacetic acid solution.
In some embodiments, the low temperature disinfection compound additive comprises 10 wt% to 60 wt% of water, 40 wt% to 70 wt% of antifreeze, 0 wt% to 5 wt% of odor masking agent, 0.01 wt% to 8 wt% of synergist, 0 wt% to 5 wt% of corrosion inhibitor, and 0.01 wt% to 5 wt% of stabilizer. The antifreezing agent with different amounts is added into the raw material of the low-temperature disinfection compound auxiliary agent, so that the lowest use temperature of the system can be reduced, and the system can be used at different low temperatures; the odor masking agent is added, so that the volatilization and irritation of the system disinfectant can be reduced; the corrosion inhibitor is added, so that the corrosion of the system to the metal surface can be slowed down; the stability of the system can be enhanced by adding the stabilizer; the synergist is added, so that the disinfection effect of the system can be enhanced, the disinfection time is shortened, the disinfection qualification rate is improved, and the disinfection effect is ensured.
The antifreezing agent is selected from organic solvents. The organic solvent is selected from one or more of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butanediol, hexanediol, diethylene glycol, methanol, triethylene glycol and diethylene glycol monoalkyl ether. The odor masking agent is selected from propylene glycol alginate.
The synergist is selected from the combination of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone and azone and PEG/PPG-copolymer. Preferably, the content of the PEG/PPG copolymer in the synergist of the PEG/PPG-17/6 is 20 wt% -60 wt%
The corrosion inhibitor comprises 5-30 wt% of phytic acid, 10-30 wt% of pentaerythritol, 5-20 wt% of benzotriazole and 10-40 wt% of siloxane. The stabilizer comprises the following raw materials in percentage by weight: 0.1-1.5 wt% of ethylenediamine tetramethylene phosphonic acid, 0.1-3 wt% of polyhydric alcohol phosphate, 0-1 wt% of ethyl acetate, 0-3 wt% of acetic acid and 0-1 wt% of ethanol.
In another aspect, the present invention relates to a potentiator for ultra-low temperature peroxyacetic acid disinfectants, the potentiator being selected from the group consisting of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone, azone in combination with a PEG/PPG copolymer.
Preferably, the PEG/PPG copolymer is blended with one or more than two of polyethylene glycol 200, polyethylene glycol 400, thiazone and azone to prepare a mixture, and the mixture is used as a synergist of the ultra-low temperature peroxyacetic acid disinfectant, so that the disinfection and sterilization effects of the ultra-low temperature peroxyacetic acid disinfectant can be effectively improved.
Preferably, the content of the PEG/PPG copolymer in the synergist is 20 wt% to 60 wt%.
In another aspect, the present invention also relates to the use of the above synergist for peracetic acid disinfectants to be added to disinfectants comprising peracetic acid to achieve good disinfection activity and disinfection yield of the peracetic acid disinfectant at a temperature of-30 ℃ for a short period of time.
In another aspect, the invention relates to a preparation method of the ultralow temperature peroxyacetic acid disinfectant, which is obtained by mixing a low temperature disinfection compound auxiliary agent with peroxyacetic acid.
The preparation method of the low-temperature disinfection composite auxiliary agent comprises the following steps:
s1, quantitatively weighing water, adding the water into a stirring vessel, quantitatively weighing the water-soluble corrosion inhibitor, adding the water-soluble corrosion inhibitor, and stirring until the water-soluble corrosion inhibitor is dissolved;
s2 quantitatively weighing the odor masking agent, adding the odor masking agent into the S1 product, and heating for dissolving;
s3, quantitatively weighing the organic alcohol antifreezing agent, adding the quantitatively weighed alcohol-soluble raw material, and stirring until the alcohol-soluble raw material is dissolved;
s4, stirring and mixing the S2 and the S3 products uniformly, filtering and filling.
The preparation method of the ultralow-temperature peracetic acid disinfectant comprises the following steps of taking 10-60 wt% of water, 40-70 wt% of antifreezing agent, 0-1 wt% of odor masking agent, 0.01-8 wt% of synergist, 0-5 wt% of corrosion inhibitor and 0.01-5 wt% of stabilizer as raw materials and raw material components, wherein the raw materials and the raw material components account for the total weight of the ultralow-temperature peracetic acid disinfectant.
The preparation method of the ultralow-temperature peroxyacetic acid disinfectant comprises the step of combining at least one synergist selected from polyethylene glycol 200, polyethylene glycol 400, thiazone and azone with a PEG/PPG-17/6 copolymer.
The preparation method of the peroxyacetic acid low-temperature disinfectant comprises the following steps of raw material composition of the stabilizer, wherein the components account for the total weight proportion of the disinfectant: 0.1 to 1.5 weight percent of ethylenediamine tetramethylene phosphonic acid, 0.1 to 3 weight percent of polyhydric alcohol phosphate, 0 to 1 weight percent of ethyl acetate, 0 to 1 weight percent of ethanol and 0 to 3 weight percent of acetic acid.
Disclosed herein are embodiments of a method for preparing an ultra-low temperature peroxyacetic acid disinfectant, which is prepared by mixing a high concentration liquid peroxyacetic acid with a low temperature disinfectant compound adjuvant.
The low-temperature test method comprises the following steps:
according to the technical requirement for evaluating the sanitation and safety of the low-temperature disinfectant, 5mL of application liquid prepared by the low-temperature disinfectant in proportion is placed at a corresponding low temperature for overnight (more than 8h), and the properties of the application liquid are observed and recorded. The low-temperature disinfectant is judged to be qualified if the low-temperature disinfectant is kept in a liquid state and has no precipitation or crystallization.
Disinfectant volatility monitoring method
The method for detecting the volatility of the disinfectant system comprises the following steps: the solution is respectively and uniformly sprayed on the surface of a 24cm by 33cm plastic self-sealing bag with the specification by using the disinfectant dosage of 1g/24cm by 33cm, a plastic bottle cap with the height of 1.5cm is placed at the middle position of the self-sealing bag, a disinfectant concentration test paper is wetted by water and placed on the plastic bottle cap, and the content of the peroxyacetic acid volatilized in the air is measured within 1 min.
The experimental method and evaluation basis for killing the microorganisms of the disinfectant at low temperature are as follows: sterilization experimental evaluation is carried out according to the regulations in the technical requirements for evaluating the hygiene safety of low-temperature disinfectants, the technical requirements for evaluating the hygiene safety of sterilized products (WS 628-2018) and the technical specifications for sterilization (2002 edition); at corresponding low temperature, the killing log value of the bacillus coli and the staphylococcus aureus is more than or equal to 3, namely the bacillus coli and the staphylococcus aureus are qualified; and the automatic spray disinfection equipment is matched, the multi-site simulated on-site sterilization experiment of escherichia coli and staphylococcus aureus is carried out in multiple batches in the low-temperature refrigeration house, and the disinfection qualified rate is calculated.
The method for testing and determining the corrosivity of the disinfectant on metal comprises the following steps: according to the specification in the technical Specification for disinfection (2002 edition), the corrosion rate is less than 0.0100, basically no corrosion is caused, the corrosion rate is 0.0100 to less than 0.100, slightly no corrosion is caused, the corrosion rate is 0.100 to less than 1.00, moderate corrosion is caused, and the corrosion rate is more than or equal to 1.00, and severe corrosion is caused.
Method for testing stability of disinfectant
The prepared disinfectant is placed under the condition of preservation at 20 ℃, after 14 days, the change of the concentration of the peroxyacetic acid is monitored, and the reduction rate is calculated.
Examples 1-6 preparation of ultra-low temperature peroxyacetic acid disinfectant
The ultra-low temperature peroxyacetic acid disinfectant prepared according to the method and the component proportion is subjected to a low temperature test of the ultra-low temperature peroxyacetic acid disinfectant, a corresponding low temperature killing test of escherichia coli and staphylococcus aureus, a disinfectant volatility test, a disinfectant stability test and a corrosion test on metal materials. The preparation method of the low-temperature disinfection composite auxiliary agent comprises the following steps:
step (1), quantitatively weighing water, adding the water into a stirring vessel, quantitatively weighing a water-soluble corrosion inhibitor, adding the water-soluble corrosion inhibitor, and stirring until the water-soluble corrosion inhibitor is dissolved;
step (2), quantitatively weighing the odor masking agent, adding the odor masking agent into the S1 product, and heating for dissolving;
step (3), quantitatively weighing the organic solvent antifreezing agent, adding the quantitatively weighed alcohol-soluble raw material, and stirring until the alcohol-soluble raw material is dissolved;
and (4) uniformly stirring and mixing the products obtained in the step (2) and the step (3), filtering and filling.
And (5) mixing the composite antifreezing solvent prepared in the step (4) with high-concentration liquid peroxyacetic acid according to a certain proportion as required to obtain the ultralow-temperature peroxyacetic acid disinfectant.
In order to further reduce the transportation and storage costs, optionally, the above steps may also be preferentially carried out to prepare a composite antifreeze solution with a higher concentration than the above, so as to reduce the transportation volume and weight of the disinfectant, and further add water to dilute the disinfectant for use at the use site: mixing water, high-concentration low-temperature disinfection compound auxiliary agent and high-concentration liquid peroxyacetic acid according to a certain proportion to obtain the application liquid of the ultralow-temperature peroxyacetic acid disinfectant.
The amounts of the components of examples 1-6 and the associated test data are shown in Table 1 below:
table 1 contents of each component of examples 1-6 and associated test data
As can be seen from the above table 1, the low-temperature peracetic acid disinfectant can realize effective disinfection at the temperature of-45 ℃, has low corrosivity to metal materials, and avoids damage to disinfection objects and equipment; meanwhile, the prepared working solution of the disinfectant has stable performance, the content reduction rate of the peroxyacetic acid is low after the disinfectant is placed for 14 days, the disinfection effect can be ensured, the practical problems that the working solution of the peroxide disinfectant has poor stability, needs to be prepared at present and cannot be continuously used to cause a large amount of waste are solved, and the disinfectant is environment-friendly and economical. The use of the synergist further improves the disinfection efficiency, meets the requirements of harbors, cold chain monitoring bins and cold storages on disinfection timeliness, improves the disinfection qualification rate, cuts off the propagation of microorganism cold chains and ensures the safety of cold chain articles. The ultralow-temperature peracetic acid disinfectant disclosed by the invention has the advantage of low volatility, reduces the irritation to the respiratory tract and eyes of workers, ensures the health of the workers, improves the compliance of the workers in disinfection work, and further ensures the disinfection effect of cold chain disinfection.
Comparative examples 1-4 ultra-low temperature peroxyacetic acid disinfectant, omitting or not using the synergist of the present invention
The compositions of the synergist were omitted or adjusted, and the composition and disinfection performance test results were as in example 3, as shown in Table 2 below.
TABLE 2 compositions and Performance tests of example 3 and comparative examples 1-3
Under the laboratory condition of minus 45 ℃, the comparative examples 1, 2 and 3 act on escherichia coli and staphylococcus aureus for 15min, and the killing logarithm value can be more than 3. However, 6 batches of the disinfectants prepared in the example 3 and the comparative examples 2 and 3 are respectively subjected to on-site simulation experiments on escherichia coli and staphylococcus aureus of 30 samples in total at a refrigeration house with the temperature of-45 ℃, the average log value of a staphylococcus aureus positive control group is 6.25, and the average log value of an escherichia coli positive control group is 6.38. Example 3 acts for 5min, the colony numbers of 30 samples of escherichia coli and staphylococcus aureus are both 0, and the disinfection qualified rate is 100%. In comparative examples 1, 2 and 3, the action time is 30min, and neither escherichia coli nor staphylococcus aureus can be completely killed.
Omitting the synergist used in the invention, or omitting PEG/PPG-17/6 in the synergist, the time efficiency and disinfection qualification rate of the finally obtained disinfectant are reduced. The small molecular synergist, such as the glycol 200, the thiazone and the like, can quickly promote active ingredients to enter the body through the surface layer and directly reach a target by influencing the surface layer of the bacterial body, so that the medicine can exert the effect and promote the active ingredients of the disinfectant to enter the microbial structure to exert the effect; due to the fact that the PEG/PPG block copolymer is adopted, compared with small molecules such as ethylene glycol 200 and thiacetone, the PEG/PPG block copolymer is not beneficial to free radical transfer and has a free radical quenching effect, the adverse effect of free radicals generated by decomposition of synergists with conjugated structures such as thiacetone under illumination on the stability of peracetic acid is greatly reduced, meanwhile, the rheological property of liquid can be changed, the spraying uniformity of the disinfectant at low temperature is improved, the problem of uneven spraying distribution caused by the addition of an odor shielding agent is solved, the disinfection qualified rate is improved, and the killing effect is further improved compared with the conventional technology.
4-6 of the comparison article, omitting or not using the corrosion inhibitor of the invention
The composition of the corrosion inhibitor was omitted or adjusted, and the other components were mixed in the same ratio as in example 3, and the results of the composition and sterilizing performance test are shown in Table 3 below.
Table 3 compositions and performance tests of example 3 and comparative examples 4-6
As can be seen from Table 3 above, the corrosion inhibitor was omitted in comparative example 4, the phytic acid content was high (66.7 wt%) and the pentaerythritol content was low (3.3 wt%) in comparative example 5, the pentaerythritol content was high (52.6 wt%) and the siloxane content was low (5.3 wt%) in comparative example 6. The corrosion performance of comparative examples 4 to 6 to the metal material is heavier than that of example 3 of the present invention, and thus, the corrosion inhibitor composition has more excellent corrosion resistance effect only when the phytic acid is 5 wt% to 30 wt%, the pentaerythritol is 10 wt% to 30 wt%, the benzotriazole is 5 wt% to 20 wt%, and the siloxane is 10 wt% to 40 wt%.
COMPARATIVE EXAMPLES 7-8 ultra-low temperature Peroxyacetic acid disinfectant odor masking agent adjustment
The composition of the odor masking agent was omitted or adjusted, and the remaining components were mixed in the same ratio as in example 3, and the composition and the results of the sterilization performance test were as shown in Table 4 below.
Table 4 compositions and performance tests of example 3 and comparative examples 7-9
As can be seen from Table 4 above, the odor masking agents in comparative examples 7-9 were 0 wt%, 1 wt%, 1.2 wt% in this order, and the results showed that the content of volatile disinfectant decreased as the content of the odor masking agent increased; meanwhile, with the increase of the content of the odor masking agent, the decrease rate of the content of the peracetic acid after being placed for 14 days is further reduced, because the odor masking agent adopted by the application has the functions of adsorbing and slowly releasing the peracetic acid, the stability of the peracetic acid is further improved by combining the odor masking agent and the stabilizing agent, the decrease rate is greatly reduced, and the long-acting killing effect is improved; however, after the content of the odor masking agent exceeds 1 wt%, the content of the volatile disinfectant does not change any more, and the volatility of the disinfectant tends to be stable. Therefore, in view of economy, the range of 0% to 1% by weight of the odor masking agent defined in the present invention is the most preferred choice.
Example 7 useThe ultralow-temperature peracetic acid disinfectant disclosed by the invention is used for disinfecting cold chain equipment
The ultra-low temperature peroxyacetic acid disinfectant prepared in the embodiment 3 of the invention is used for disinfection by matching with cold chain equipment. The cold chain equipment is automatic spraying and disinfecting system equipment, treats 1000-ton and 1500-ton meat products daily, and can comprehensively and effectively disinfect the outer part of the meat product package. The field simulation experiment shows that the escherichia coli and the staphylococcus aureus act for 5 minutes, the killing log value is more than 3, and the disinfection qualified rate is 100%. .
The test results of the above examples show that the low-temperature disinfectant has the advantages of low irritation, low corrosion, stability and high-efficiency disinfection capability at ultralow temperature within the preferable range of the claims, and the low-temperature disinfectant has the beneficial effects described above.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples for carrying out the invention, and that various changes in form and details may be made therein without departing from the spirit and scope of the invention in practice.
Claims (9)
1. An ultralow temperature peracetic acid disinfectant is characterized by comprising a low temperature disinfection compound auxiliary agent and peracetic acid; the content of the peroxyacetic acid is 0.1 to 1.5 weight percent based on the total weight of the ultralow-temperature peroxyacetic acid disinfectant;
the low-temperature disinfection compound additive comprises 10-60 wt% of water, 40-70 wt% of antifreezing agent, 0-1 wt% of odor masking agent, 0.01-8 wt% of synergist, 0-5 wt% of corrosion inhibitor and 0.01-5 wt% of stabilizer;
the synergist is selected from the combination of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone and azone and PEG/PPG copolymer.
2. The ultra-low temperature peroxyacetic acid disinfectant as set forth in claim 1, wherein the content of the PEG/PPG copolymer in the synergist is 20-60 wt%.
3. The ultra-low temperature peroxyacetic acid disinfectant of claim 2, wherein said PEG/PPG copolymer comprises PEG/PPG-17/6.
4. An ultra-low temperature peroxyacetic acid disinfectant according to claim 1 or 2, wherein the anti-freezing agent is selected from organic solvents selected from the group consisting of ethanol, isopropanol, n-propanol, butanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, hexylene glycol, diethylene glycol, methanol, triethylene glycol and a combination of one or more of diethylene glycol monoalkyl ethers.
5. The ultra-low temperature peroxyacetic acid disinfectant of claim 1 or 2, wherein the odor masking agent is propylene glycol alginate.
6. The ultra-low temperature peracetic acid disinfectant as set forth in claim 1 or 2, wherein the corrosion inhibitor comprises, based on the total mass of the corrosion inhibitor, 5 wt% -30 wt% of phytic acid, 10 wt% -30 wt% of pentaerythritol, 5 wt% -20 wt% of benzotriazole, and 10 wt% -40 wt% of siloxane.
7. The ultra-low temperature peroxyacetic acid disinfectant as set forth in claim 1 or 2, wherein the stabilizer comprises 0.1-1.5 wt% of ethylenediamine tetramethylene phosphonic acid, 0.1-3 wt% of polyol phosphate, 0-1 wt% of ethyl acetate, 0-1 wt% of ethanol, and 0-3 wt% of acetic acid, based on the total mass of the low temperature disinfectant composite assistant.
8. A synergist for ultra-low temperature peroxyacetic acid disinfectant, wherein the synergist is selected from the combination of at least one of polyethylene glycol 200, polyethylene glycol 400, thiaketone and azone and PEG/PPG copolymer.
9. The synergist for ultra-low temperature peroxyacetic acid disinfectant as claimed in claim 8, wherein the content of said PEG/PPG copolymer is 20-60 wt% based on the total weight of said synergist.
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| US20100222433A1 (en) * | 2009-03-02 | 2010-09-02 | Jialu Xue | Composite Disinfectant Cleaner |
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| CN104304315A (en) * | 2014-09-18 | 2015-01-28 | 魏巍 | Stable low-corrosiveness sporicide and its preparation method |
| CN106857513A (en) * | 2017-01-11 | 2017-06-20 | 北京长江脉医药科技有限责任公司 | A kind of unitary Peracetic acid solid particle disinfectant |
| CN111328807A (en) * | 2018-12-19 | 2020-06-26 | 洛阳惠中兽药有限公司 | Peroxyacetic acid solution disinfectant, and preparation and application thereof |
| KR102094972B1 (en) * | 2019-07-26 | 2020-03-30 | 주식회사 소프트아쿠아 | Liquid disinfectant having antifreezing and oxidizing properties and method for manufacturing |
| CN111226978A (en) * | 2020-03-18 | 2020-06-05 | 中国天辰工程有限公司 | Peracetic acid disinfectant |
| CN111700822A (en) * | 2020-07-23 | 2020-09-25 | 广州泰晟生物科技股份有限公司 | Skin disinfectant and preparation method thereof |
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| CN112913840A (en) * | 2021-01-06 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Ultralow-temperature peracetic acid disinfectant and preparation method thereof |
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