CN111226978A - Peracetic acid disinfectant - Google Patents
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- CN111226978A CN111226978A CN202010192876.6A CN202010192876A CN111226978A CN 111226978 A CN111226978 A CN 111226978A CN 202010192876 A CN202010192876 A CN 202010192876A CN 111226978 A CN111226978 A CN 111226978A
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Abstract
The invention provides a peroxyacetic acid disinfectant, which comprises the following raw materials, by weight, 0.1-20% of hydrogen peroxide; 0.1-5% of peroxyacetic acid; 0.001-0.1% of a stabilizer; 0.001-0.05% of corrosion inhibitor; 0.001-0.1% of a surfactant; 0.001-0.05% of long carbon chain carboxylic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%. The peroxyacetic acid disinfectant disclosed by the invention has the advantages of wide sterilization application range and quick sterilization; has higher stability and can be stably stored at room temperature; the coating basically has no corrosion to metals such as molybdenum-chromium alloy, stainless steel, carbon steel, copper and the like and endoscope materials, and greatly improves the limitation caused by the corrosivity of the traditional peracetic acid. The peroxyacetic acid disinfectant can be directly used without dilution, greatly improves the use convenience of the peroxyacetic acid disinfectant, and can be directly applied to a plurality of disinfection fields and scenes such as air disinfection, food sanitation and corrosion prevention, high-level disinfection of clinical samples and medical instruments (such as endoscopes and hemodialysis instruments) and the like.
Description
Technical Field
The invention belongs to the technical field of chemical disinfectants, and particularly relates to a peroxyacetic acid disinfectant.
Background
Peracetic acid is a high-efficiency broad-spectrum chemical disinfectant, has the advantages of low use concentration, strong bactericidal action, short disinfection time, no toxicity of decomposition products and the like, is applied in the disinfection field at home and abroad for nearly half a century, plays an important role in the aspects of infectious diseases, hospital infection prevention and control, food processing industry sanitary corrosion prevention and the like, is widely applied to disinfection and sterilization of medical instruments and disinfection of epidemic sources such as environment, property table, air and the like, and is mainly used as a disinfectant for the disinfection and the disinfection in hospitals and other public places particularly during the SARS epidemic situation in 2003.
Although the concentration of the peroxyacetic acid sold in the market is 16-18 wt% mostly, the peroxyacetic acid is unstable and easy to decompose, and the decomposition speed of the peroxyacetic acid is accelerated along with the prolonging of the storage time, so that the concentration of the peroxyacetic acid is reduced continuously. Under the condition of 37 ℃ without adding any stabilizer, the concentration of over 15 weight percent of peroxyacetic acid can be reduced by 25 percent after being stored for 1 day; the peroxyacetic acid with the concentration of 10-15 wt% can be reduced by 6.5% on average per day; the concentration below 10 wt% can be reduced by 5.1% per day on average.
To overcome the instability of peracetic acid, the peracetic acid products commercially available in recent years tend to fall into two types: one is binary type, and its product is divided into A, B doses, which are stored separately at ordinary times. The A, B two agents are mixed according to a certain proportion before use, and are diluted to the required concentration for use after being placed for 24-48 hours. If the temperature during mixing is lower than 10 ℃, the reaction time needs to be further prolonged, otherwise the concentration of the peroxyacetic acid cannot reach the mark concentration. However, the binary package peroxyacetic acid disinfectant prepared by the prior art has overlong reaction time, at least 1-3 days, and cannot meet the requirement of use at any time; meanwhile, the mixed peroxyacetic acid is still the same as the commercial 16-18 wt% peroxyacetic acid, the property is extremely unstable, the peroxyacetic acid concentration is reduced rapidly, and the reduction trend is accelerated along with the increase of the peroxyacetic acid concentration; in addition, peracetic acid is strongly acidic and strongly corrosive to metals and the like. Therefore, in the practical application process, the peroxyacetic acid can only be prepared according to the needs, which brings inconvenience to the use and greatly limits the application of the peroxyacetic acid. The other is a simple type, namely various auxiliary agents are added into a peroxyacetic acid system to serve as stabilizing agents, such as inorganic phosphate, alkyl alcohol, hydroxyquinoline and the like, and meanwhile, in order to improve the wettability and the adhesiveness of the disinfectant on the surface of a target disinfectant, a certain amount of surfactant and a medium-high molecular weight polymer tackifier with biological activity are often required to be added into the disinfectant.
Patent CN110432269A discloses a peroxyacetic acid disinfectant with gel property, which is constructed by using gelatin dispersion, surfactant, sepiolite, organic zinc, persulfate and other auxiliaries, and the activity of peroxyacetic acid is limited by the action of gel network skeleton, so as to ensure the stability of peroxyacetic acid. However, the gel peroxyacetic acid disinfectant prepared by the method has the risks of high viscosity, difficult dispersion and the like, and meanwhile, the addition of organic zinc can also serve as heavy metal ions to accelerate the decomposition of peroxyacetic acid. Patent CN10296590A discloses a polyhydroxy polycarboxylic multi-ligand structure compound HWP to stabilize peroxyacetic acid disinfectant, but the preparation process of the compound HWP is complex, and the reaction time is as long as 6-8 h. Patent CN1259829C introduces small molecules such as 8-hydroxyquinoline to increase the stability of peroxyacetic acid, but 8-hydroxyquinoline has been proved to be a carcinogen, which has been banned in european and american countries as a stabilizer for disinfectants. In patent CN101828551A, a hydrolyzed maleic anhydride copolymer and organic or inorganic phosphoric acid are used as a compound stabilizer to realize the stability of the peroxyacetic acid disinfectant.
The prior art has various characteristics in the aspect of improving the stability of peroxyacetic acid, but the concentration needs to be calibrated and then diluted to the required concentration when in use, so that the use is inconvenient; meanwhile, most of the added peroxyacetic acid stabilizer has single function, and part of the disclosed technologies still corrode metals, object surfaces and the like, so that the peroxyacetic acid stabilizer is difficult to be used for high-level disinfection of medical instruments (such as endoscopes and hemodialysis instruments) and the like.
Disclosure of Invention
In view of the above, the present invention aims to provide a peroxyacetic acid disinfectant, which can be directly used without dilution, provides a high-efficiency disinfection and sterilization effect, greatly improves the problems of inconvenient use, instability and easy decomposition of the traditional peroxyacetic acid, effectively reduces the corrosivity of the peroxyacetic acid to metal, and is suitable for air disinfection and food sanitation preservation, especially for high-level disinfection of medical instruments (such as endoscopes and hemodialysis instruments). The peroxyacetic acid disinfectant provided by the invention has the advantages of simple preparation method, good sterilization effect, controllable metal corrosivity and strong stability, is a broad-spectrum disinfectant and can meet the special requirements of high-level disinfection of medical instruments and the like.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
a peroxyacetic acid disinfectant comprises the following raw materials, by weight, 0.1-20% of hydrogen peroxide; 0.1-5% of peroxyacetic acid; 0.001-0.1% of a stabilizer; 0.001-0.05% of corrosion inhibitor; 0.001-0.1% of a surfactant; 0.001-0.05% of long carbon chain carboxylic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
Preferably, the hydrogen peroxide-containing composite material comprises 0.5-10% of hydrogen peroxide by weight; 0.2-1% of peroxyacetic acid; 0.005-0.05% of a stabilizer; 0.005-0.03% of corrosion inhibitor; 0.01-0.1% of surfactant; 0.005-0.03% of long carbon chain carboxylic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
Preferably, the stabilizer is one or a mixture of two of organic phosphide and inorganic phosphide, and the organic phosphide is one or more of hydroxyethylidene diphosphonic acid, aminotrimethylene phosphoric acid, diethylenetriamine pentamethylene phosphoric acid, triethylene tetramine hexamethylene phosphoric acid, bis (1, 6-hexamethylene) triamine pentamethylene phosphoric acid and polyaminopolyether tetramethylene phosphoric acid; the inorganic phosphide is one or more than two of sodium tripolyphosphate, sodium pyrophosphate, sodium hexametaphosphate and sodium polyphosphate.
Preferably, the corrosion inhibitor is a water-soluble imidazoline amide.
Preferably, the water-soluble imidazoline amide is a compound which is obtained by condensation-cyclization reaction of long-carbon-chain carboxylic acid and organic polyamine according to a molar ratio of 1:1 and has a plurality of nitrogen-containing groups; wherein the long carbon chain carboxylic acid is a C8-C22 fatty acid; the organic polyamine is one or more of diethylenetriamine, triethylene tetramine, tetraethylene pentamine and polyethylene polyamine.
Preferably, the long-carbon-chain carboxylic acid in the imidazoline amide is one or more of naphthenic acid, n-octanoic acid, n-nonanoic acid, n-decanoic acid, dodecanoic acid, hexadecanoic acid, octadecanoic acid and docosanoic acid, and preferably one or more of n-octanoic acid, n-decanoic acid and dodecanoic acid; the organic polyamine is one or more than two of triethylene tetramine, tetraethylene pentamine and polyethylene polyamine.
Preferably, the water-soluble imidazoline amide is synthesized by the following steps of respectively weighing long-carbon-chain carboxylic acid and organic polyamine of C8-C22, and performing dehydration condensation reaction at 110-130 ℃ according to the molar ratio of 1:1 for 1-2 hours; and (3) when no water is generated in the water separator, heating to 200-240 ℃, keeping the temperature for 1-2 hours, and performing cyclization reaction to obtain the water-soluble imidazoline amide.
Preferably, the surfactant is an anionic surfactant; the anionic surfactant is one or more than two of C8-C16 long carbon chain sulfate, sulfonate, benzene sulfonate and toluene sulfonate.
The long-carbon-chain carboxylic acid is preferably one or more of C8-C16 long-carbon-chain carboxylic acids such as n-octanoic acid, iso-octanoic acid, n-nonanoic acid, n-decanoic acid, dodecanoic acid and hexadecanoic acid, and preferably one or more of n-octanoic acid, n-decanoic acid and dodecanoic acid.
Preferably, the water must meet the water standard of more than three levels GB/T6682-2008.
The research principle of the sterilization, disinfection, corrosion inhibition and stability of the peroxyacetic acid disinfectant disclosed by the invention is as follows:
(1) the key point of the invention is to maintain the sterilizing effect of the monoprotic peroxyacetic acid disinfectant, improve the stability of the monoprotic peroxyacetic acid disinfectant, reduce the corrosion of the monoprotic peroxyacetic acid disinfectant to metal, material surfaces and the like, make the monoprotic peroxyacetic acid disinfectant suitable for marketing and popularization, and particularly meet the special requirements of high-level sterilization of medical instruments and the like. Through research, two important factors influencing the stability of the peroxyacetic acid exist, namely, the process of synthesizing the peroxyacetic acid by hydrogen peroxide and acetic acid is an equilibrium reaction. When the content of the peroxyacetic acid is too high, the temperature is increased, and the like, the reverse reaction can be carried out in a balanced manner; secondly, under the action of various trace metal ions, peroxyacetic acid can be continuously catalyzed to generate oxidation-reduction reaction, so that the content of peroxyacetic acid is rapidly reduced. Various trace metal ions inevitably exist in the raw materials of the peroxyacetic acid disinfectant, and the metal ions existing in the packing material are continuously dissolved out to enter the product in the storage process.
(2) In the scheme of the invention, the hydrogen peroxide and the peroxyacetic acid exist in the disinfectant system according to a certain proportion, which is beneficial to reducing the occurrence of reverse equilibrium from the peroxyacetic acid to the hydrogen peroxide and improving the stability of the peroxyacetic acid. Meanwhile, the disinfection and sterilization effect of the peroxyacid disinfectant is mainly realized by releasing atomic oxygen from peroxyacid, irreversible oxidation and sterilization are carried out on harmful microorganisms, the concentration of peroxyradicals in the disinfectant is improved, the disinfection and sterilization effect is improved, peroxyacetic acid and hydrogen peroxide ionize peroxyradical ions in an aqueous solution, the concentration of the peroxyradical ions in the disinfectant is improved, and the disinfection and sterilization effect is further improved. Meanwhile, the acetic acid is fully reacted, so that the excessively strong acidity can be avoided from corroding the disinfection instrument, particularly the metal surface.
(3) In the scheme of the invention, the addition of the organic or inorganic phosphide stabilizer can reduce the content of metal ions in the disinfectant by utilizing the complexation of phosphorus atoms and metal ions, and meanwhile, phosphide can prevent the effective oxygen in peroxyacetic acid from being separated from molecules, so that the two aspects of the two functions simultaneously prevent the decomposition failure of the peroxyacetic acid in the storage process and ensure the long-term stability of the peroxyacetic acid disinfectant in the use process. In the scheme of the invention, the disinfectant has good stability, is not easy to decompose at normal temperature, and has a storage period of up to one year.
(4) In the scheme of the invention, the water-soluble imidazoline amide corrosion inhibitor added into the disinfectant system is a compound with a plurality of nitrogen-containing groups, which is obtained by condensation-cyclization reaction of long-carbon-chain carboxylic acid and organic polyamine according to the molar ratio of 1: 1. A nitrogen atom on an imidazoline ring in the molecular structure of the metal corrosion inhibitor can generate a coordination bond with a d-vacant orbit on the surface of the metal, and a nonpolar alkyl chain can form a hydrophobic layer, so that a corrosion medium is prevented from entering the surface of the metal, and a corrosion inhibition effect is achieved. On one hand, other nitrogen atoms can form coordination, inlaying and chelating effects with trace metal ions in a disinfectant system, shield and block the decomposition and catalysis effects of impurity metal ions on peroxyacetic acid, and improve the stability of the unitary peroxyacetic acid disinfectant; on the other hand, other nitrogen atoms are matched with nonpolar alkyl chains, and can partially serve as a surfactant to improve the wettability and the adhesiveness of the peroxyacetic acid disinfectant.
(5) In the scheme of the invention, the anionic surfactant added into the disinfectant system can accelerate the dissolution of the stabilizer, the corrosion inhibitor, the long-carbon-chain carboxylic acid and other components in the aqueous solution, and simultaneously can increase the interfacial tension between the surfaces of the harmful microorganisms and the aqueous solution, increase the contact area between the peroxyacid radicals and the surfaces of the harmful microorganisms and the permeability of cell walls and cell membranes of the harmful microorganisms, thereby reducing the resistance of the peroxyacid radicals entering the harmful microorganisms and improving the sterilization effect of the peroxyacid radicals.
(6) In the scheme of the invention, long carbon chain carboxylic acid added into the disinfectant system is combined with peroxide ions ionized in the system to generate long carbon chain peroxy acid, so that the disinfection and sterilization effects of the disinfectant are further improved; in addition, the long carbon chain carboxylic acid can also play a role in increasing the wettability and the permeability of the surfactant by utilizing the hydrophobic long carbon chain.
Compared with the prior art, the peroxyacetic acid disinfectant disclosed by the invention has the following advantages and characteristics:
(1) in the peroxyacetic acid disinfectant, hydrogen peroxide and peroxyacetic acid exist in a disinfectant system according to a certain proportion, so that the peroxyacetic acid disinfectant has an excellent quick sterilization effect, can effectively kill staphylococcus aureus, escherichia coli, bacillus subtilis var niger, candida albicans and the like, can achieve a complete sterilization effect within 5 minutes, and has the advantages of wide sterilization application range and quick sterilization. The disinfectant can be directly used in the concentration range of 0.5 wt% of peroxyacetic acid without dilution, and the disinfection effect of the disinfectant is far better than that of a commercially available binary packaged peroxyacetic acid disinfectant under the concentration condition of 0.5 wt%;
(2) the stabilizing agent, the corrosion inhibitor, the surfactant and the long-carbon-chain carboxylic acid added into the peroxyacetic acid disinfectant are all multifunctional auxiliaries, and the decomposition and catalysis effects of impurity metal ions on the peroxyacetic acid are shielded and blocked through the coordination, mosaic and chelation effects of multi-phosphorus and multi-nitrogen groups and trace metal ions contained in the auxiliaries, so that the disinfection and sterilization effects of the peroxyacetic acid are improved, and the stability of the unitary peroxyacetic acid disinfectant is greatly improved. In the scheme of the invention, the disinfectant has good stability, is not easy to decompose at normal temperature, and has a storage period as long as one year;
(3) according to the water-soluble imidazoline amide corrosion inhibitor used in the peroxyacetic acid disinfectant, a nitrogen atom on an imidazoline ring in a molecular structure of the water-soluble imidazoline amide corrosion inhibitor can generate a coordination bond with a d-vacant orbit on a metal surface, and a nonpolar alkyl chain can form a hydrophobic layer, so that a corrosion medium is prevented from entering the metal surface, and a corrosion inhibition effect is achieved. The added water-soluble imidazoline amide corrosion inhibitor can basically have no corrosion to metals such as molybdenum-chromium alloy, stainless steel, carbon steel, copper and the like and endoscope materials, greatly improves the limitation of the traditional peracetic acid caused by the corrosivity, and is particularly suitable for high-level disinfection of medical instruments (such as endoscopes and hemodialysis instruments) and the like while improving the stability of the peracetic acid;
(4) the peroxyacetic acid disinfectant can be directly used without dilution, greatly improves the use convenience of the peroxyacetic acid disinfectant, and can be directly applied to a plurality of disinfection fields and scenes such as air disinfection, food sanitation and corrosion prevention, high-level disinfection of clinical samples and medical instruments (such as endoscopes and hemodialysis instruments) and the like.
Drawings
FIG. 1 is a graph showing the change of peracetic acid content with time in the peracetic acid sterilizing solutions prepared in example 3 and comparative example 3 of the present invention.
Detailed Description
Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.
The present invention will be described in detail with reference to examples.
Example 1
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 2.5 percent of hydrogen peroxide; 0.5% of peroxyacetic acid; triethylene tetramine hexamethylene phosphate 0.03%; 0.01% of water-soluble imidazoline amide; sodium dodecyl toluene sulfonate 0.02%; 0.01 percent of n-octanoic acid and the balance of water, and the sum of the weight percentages of the raw materials is 100 percent.
The preparation method of the water-soluble imidazoline amide corrosion inhibitor described in the embodiment 1 comprises the following steps: respectively weighing 17.2g of n-capric acid, 14.6g of triethylene tetramine, 1.0g of glacial acetic acid and 50g of toluene, adding the materials into a three-necked bottle provided with a water separator, heating to 120 ℃, bringing water generated in the reaction and the toluene into the water separator in an azeotrope form, and maintaining the condensation reaction for 1 h; and (3) when no water is generated in the water separator, heating to 210 ℃, keeping the temperature for 1.5 hours, carrying out cyclization reaction, and separating to obtain the water-soluble imidazoline amide corrosion inhibitor.
Example 2
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 5 percent of hydrogen peroxide; 0.2% of peroxyacetic acid; 0.1 percent of sodium tripolyphosphate; 0.005% of water-soluble imidazoline amide; sodium hexadecyl sulfonate 0.08%; 0.005% of n-decanoic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
The preparation method of the water-soluble imidazoline amide corrosion inhibitor in the embodiment 2 comprises the following steps: respectively weighing 20g of n-dodecanoic acid, 19.0g of tetraethylenepentamine, 1.0g of glacial acetic acid and 50g of toluene, adding the n-dodecanoic acid, the 19.0g of tetraethylenepentamine, the 1.0g of glacial acetic acid and the 50g of toluene into a three-necked bottle with a water separator, heating to 130 ℃, bringing water generated in the reaction and the toluene into the water separator in an azeotrope form, and maintaining the condensation reaction for 1.5 hours; and (3) when no water is generated in the water separator, heating to 220 ℃, keeping the temperature for 2 hours, carrying out cyclization reaction, and separating to obtain the water-soluble imidazoline amide corrosion inhibitor.
Example 3
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 17.5 percent of hydrogen peroxide; 5% of peroxyacetic acid; bis (1, 6-hexylene) triamine pentamethylene phosphoric acid 0.08%; 0.05% of water-soluble imidazoline amide; 0.1 percent of sodium dodecyl sulfate; 0.05 percent of dodecanoic acid and the balance of water, wherein the sum of the weight percent of the raw materials is 100 percent.
The preparation method of the water-soluble imidazoline amide corrosion inhibitor described in the embodiment 3 comprises the following steps: respectively weighing 14.5g of n-octanoic acid, 24g of polyethylene polyamine, 1.5g of glacial acetic acid and 45g of toluene, adding the n-octanoic acid, the 24g of polyethylene polyamine, the glacial acetic acid and the toluene into a three-necked bottle with a water separator, heating to 126 ℃, bringing water generated in the reaction and the toluene into the water separator in an azeotrope form, and maintaining the condensation reaction for 2 hours; and (3) when no water is generated in the water separator, heating to 230 ℃, keeping the temperature for 1.5 hours, carrying out cyclization reaction, and separating to obtain the water-soluble imidazoline amide corrosion inhibitor.
Example 4
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 8 percent of hydrogen peroxide; 1% of peroxyacetic acid; sodium pyrophosphate 0.005%; 0.001% of water-soluble imidazoline amide; 0.002% of sodium dodecyl toluene sulfonate; 0.002% of n-octanoic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
The preparation method of the water-soluble imidazoline amide corrosion inhibitor described in the embodiment 4 comprises the following steps: respectively weighing 14.5g of n-octanoic acid, 19.0g of tetraethylenepentamine, 1.0g of glacial acetic acid and 50g of toluene, adding the n-octanoic acid, 19.0g of tetraethylenepentamine, 1.0g of glacial acetic acid and 50g of toluene into a three-necked bottle with a water separator, heating to 126 ℃, bringing water generated in the reaction and the toluene into the water separator in an azeotrope form, and maintaining the condensation reaction for 1 h; and (3) when no water is generated in the water separator, heating to 230 ℃, keeping the temperature for 1.5 hours, carrying out cyclization reaction, and separating to obtain the water-soluble imidazoline amide corrosion inhibitor.
Example 5
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 1% of hydrogen peroxide; 0.3% of peroxyacetic acid; 0.05% of hydroxyethylidene diphosphate; 0.03 percent of water-soluble imidazoline amide; sodium dodecyl sulfate 0.02%; 0.03 percent of n-decanoic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100 percent.
The preparation method of the water-soluble imidazoline amide corrosion inhibitor described in the embodiment 5 comprises the following steps: respectively weighing 17.2g of n-capric acid, 19.0g of tetraethylenepentamine, 1.0g of glacial acetic acid and 50g of toluene, adding into a three-necked bottle provided with a water separator, heating to 135 ℃, bringing water generated in the reaction and the toluene into the water separator in an azeotrope form, and maintaining the condensation reaction for 1 h; and (3) when no water is generated in the water separator, heating to 225 ℃, keeping the temperature for 1h, performing cyclization reaction, and separating to obtain the water-soluble imidazoline amide corrosion inhibitor.
Comparative example 1 (with respect to example 1, only stabilizer was added)
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 2.5 percent of hydrogen peroxide; 0.5% of peroxyacetic acid; triethylene tetramine hexamethylene phosphate 0.03%; the balance of water, and the sum of the weight percentages of the raw materials is 100 percent.
Comparative example 2 (with respect to example 1, no corrosion inhibitor added)
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 2.5 percent of hydrogen peroxide; 0.5% of peroxyacetic acid; triethylene tetramine hexamethylene phosphate 0.03%; sodium dodecyl toluene sulfonate 0.02%; 0.01 percent of n-octanoic acid and the balance of water, and the sum of the weight percentages of the raw materials is 100 percent.
Comparative example 3 (with respect to example 3, only stabilizer was added)
The peroxyacetic acid disinfectant consists of the following raw materials in percentage by weight, 17.5 percent of hydrogen peroxide; 5% of peroxyacetic acid; bis (1, 6-hexylene) triamine pentamethylene phosphoric acid 0.08%; the balance of water, and the sum of the weight percentages of the raw materials is 100 percent.
The disinfecting and sterilizing effects, corrosion inhibition effects and stability of the peracetic acid disinfectant prepared in the above examples are examined below.
First, sterilization and disinfection experiment
The sterilizing effects of the four disinfectant solutions on staphylococcus aureus, escherichia coli, bacillus subtilis var niger and candida albicans are shown in tables 1-4 by carrying out an experimental sterilization and disinfection experiment by using the disinfectant solutions prepared in the formulas of example 1 and example 2 of the invention and comparative example 1 and a commercially available 18.5% binary packaging type peroxyacetic acid disinfectant solution (prepared 24h before use, subjected to content measurement during use and diluted into a sample with the mass concentration of 0.5% by using sterile water).
TABLE 1 killing effect of four peroxyacetic acid sterilizing solutions on staphylococcus aureus
TABLE 2 killing effect of four kinds of peroxyacetic acid disinfectant on Escherichia coli
TABLE 3 killing effect of four kinds of peroxy acetic acid sterilizing liquid on Bacillus subtilis var niger spores
TABLE 4 Disinfection Effect of four Peroxyacetic acid disinfectants on Candida albicans
The above experimental results show that: under the condition that the mass concentration of the peroxyacetic acid is 0.5 wt%, the sterilizing effect of the sterilizing liquid of the embodiment 1 and the comparative example 1 is far better than that of a commercially available binary packaging type peroxyacetic acid sterilizing liquid, and the fact that hydrogen peroxide and peroxyacetic acid exist in a certain proportion in the sterilizing liquid system of the invention is proved to be beneficial to improving the concentration of peroxygen ions in the sterilizing liquid while reducing the occurrence of a reversible reaction, so that the sterilizing effect is improved; even if the concentration of peracetic acid in example 2 is reduced to 0.2 wt%, excellent bactericidal properties are obtained. The sterilizing effect of the sterilizing liquid of the embodiment 1 and the embodiment 2 is slightly better than that of the sterilizing liquid prepared in the comparative example 1, which shows that the corrosion inhibitor, the surfactant and the long-carbon-chain carboxylic acid in the sterilizing liquid system of the invention can generate a synergistic interaction effect, on one hand, the surfactant and the long-carbon-chain carboxylic acid can increase the contact area of the peroxyacid radical and the surface of the harmful microorganism and the permeability of cell walls and cell membranes of the harmful microorganism, thereby reducing the resistance of the peroxyacid radical entering the harmful microorganism and improving the sterilizing effect of the peroxyacid radical, and on the other hand, the long-carbon-chain carboxylic acid is combined with the ionized peroxyacid radical ions in the system to generate the long-carbon-chain peroxyacid, and further improving the sterilizing effect of the.
Therefore, the peroxyacetic acid disinfectant disclosed by the invention is convenient to use, can be directly used without dilution, is excellent in sterilization effect, can effectively kill staphylococcus aureus, escherichia coli, bacillus subtilis var niger spores and candida albicans, can completely kill within 5min, and has the advantages of wide sterilization application range and rapid sterilization.
Second, metal corrosion test
The disinfectant liquids of example 1 and comparative example 2 of the present invention and a commercially available binary packaged peracetic acid disinfectant liquid (prepared 24 hours before use, subjected to content measurement during use, and diluted with ultrapure water to a mass concentration of 0.5%) were subjected to a metal corrosion test on molybdenum-chromium alloy, stainless steel, carbon steel, and copper, and the results are shown in table 5:
TABLE 5 Experimental results of the corrosiveness of two peroxyacetic acid disinfectants to each metal
As can be seen from the experimental results in table 5: the peracetic acid disinfectant provided by the embodiment 1 of the invention basically has no corrosion to molybdenum-chromium alloy, stainless steel, carbon steel and copper, and is far superior to the disinfectant which is not added with a corrosion inhibitor in the comparative example 2. Meanwhile, according to the grade division of corrosion rate in the disinfection technical specification, the commercially available binary packaging type peracetic acid disinfectant has severe corrosion to stainless steel, carbon steel and copper. The water-soluble imidazoline amide corrosion inhibitor added into the disinfectant system can effectively prevent corrosive media from entering the metal surface to play a corrosion inhibition role, the molybdenum-chromium alloy, stainless steel and other endoscope materials are basically not corroded, the limitation of the traditional peracetic acid caused by the corrosivity is greatly improved, and the disinfectant system is particularly suitable for high-level disinfection of medical instruments (such as endoscopes and hemodialysis instruments).
Third, stability test
The stability of two peroxyacetic acid disinfectants is examined by taking the disinfectants of the embodiment 3 and the comparative example 3 of the invention as materials. The peroxyacetic acid content is sampled at the same time interval to compare and study the stability of the disinfectant, and the curve of the peroxyacetic acid content along with time is shown as the attached figure 1. The peracetic acid disinfectant of fig. 1 of example 3 has better stability for 12 months, while the peracetic acid disinfectant of comparative example 3 has a concentration of peracetic acid that starts to decrease after 10 months. The corrosion inhibitor, the surfactant and the long-carbon-chain carboxylic acid added into the peroxyacetic acid disinfectant system are multifunctional auxiliaries, and the decomposition and catalysis effects of impurity metal ions on the peroxyacetic acid are shielded and blocked through the coordination, mosaic and chelation effects of the multi-phosphorus and multi-nitrogen groups contained in the stabilizer and the corrosion inhibitor and trace metal ions, so that the disinfection and sterilization effects of the peroxyacetic acid are improved, and the stability of the unitary peroxyacetic acid disinfectant is greatly improved.
The detection results show that compared with the products sold in the market, the peroxyacetic acid disinfectant disclosed by the invention is convenient to use and can be directly used without dilution; the sterilizing and disinfecting effect of the disinfectant is far better than that of a commercially available binary packaging peroxyacetic acid disinfectant, and the disinfectant has the advantages of wide sterilizing application range and quick sterilization; the stability of the product is greatly improved, and the product can be stably stored for 1 year at room temperature; in addition, the disinfectant basically has no corrosion to metals such as molybdenum-chromium alloy, stainless steel, carbon steel, copper and the like and endoscope materials, greatly improves the limitation caused by the corrosivity of the traditional peracetic acid, and can be directly applied to a plurality of disinfection fields and scenes such as air disinfection, food sanitation anticorrosion, high-level disinfection of clinical samples and medical instruments (such as endoscopes and hemodialysis instruments) and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. A peroxyacetic acid disinfectant is characterized in that: the hydrogen peroxide-containing coating comprises the following raw materials, by weight, 0.1-20% of hydrogen peroxide; 0.1-5% of peroxyacetic acid; 0.001-0.1% of a stabilizer; 0.001-0.05% of corrosion inhibitor; 0.001-0.1% of a surfactant; 0.001-0.05% of long carbon chain carboxylic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
2. The peroxyacetic acid disinfectant of claim 1, wherein: the hydrogen peroxide is 0.5-10% of raw materials in percentage by weight; 0.2-1% of peroxyacetic acid; 0.005-0.05% of a stabilizer; 0.005-0.03% of corrosion inhibitor; 0.01-0.1% of surfactant; 0.005-0.03% of long carbon chain carboxylic acid and the balance of water, wherein the sum of the weight percentages of the raw materials is 100%.
3. The peroxyacetic acid disinfectant of claim 1, wherein: the stabilizer is one or a mixture of two of organic phosphide and inorganic phosphide, and the organic phosphide is one or more than two of hydroxyl ethylidene diphosphonic acid, aminotrimethylene phosphoric acid, diethylene triamine pentamethylene phosphoric acid, triethylene tetramine hexamethylene phosphoric acid, bis (1, 6-hexamethylene) triamine pentamethylene phosphoric acid and polyaminopolyether tetramethylene phosphoric acid; the inorganic phosphide is one or more than two of sodium tripolyphosphate, sodium pyrophosphate, sodium hexametaphosphate and sodium polyphosphate.
4. The peroxyacetic acid disinfectant of claim 1, wherein: the corrosion inhibitor is water-soluble imidazoline amide.
5. The peroxyacetic acid disinfectant of claim 4, wherein: the water-soluble imidazoline amide is a compound which is obtained by condensation-cyclization reaction of long-carbon-chain carboxylic acid and organic polyamine according to the molar ratio of 1:1 and has a plurality of nitrogen-containing groups; wherein the long carbon chain carboxylic acid is a C8-C22 fatty acid; the organic polyamine is one or more of diethylenetriamine, triethylene tetramine, tetraethylene pentamine and polyethylene polyamine.
6. The peroxyacetic acid disinfectant of claim 5, wherein: the long carbon chain carboxylic acid in the imidazoline amide is one or more than two of naphthenic acid, n-octanoic acid, n-nonanoic acid, n-decanoic acid, dodecanoic acid, hexadecanoic acid, octadecanoic acid and docosanoic acid, preferably one or more than two of n-octanoic acid, n-decanoic acid and dodecanoic acid; the organic polyamine is one or more than two of triethylene tetramine, tetraethylene pentamine and polyethylene polyamine.
7. A peroxyacetic acid disinfectant as set forth in any one of claims 4 to 6, wherein: the water-soluble imidazoline amide is synthesized by the following steps of respectively weighing long-carbon-chain carboxylic acid and organic polyamine of C8-C22, and performing dehydration condensation reaction at 110-130 ℃ according to the molar ratio of 1:1 for 1-2 h; and (3) when no water is generated in the water separator, heating to 200-240 ℃, keeping the temperature for 1-2 hours, and performing cyclization reaction to obtain the water-soluble imidazoline amide.
8. The peroxyacetic acid disinfectant of claim 1, wherein: the surfactant is an anionic surfactant; the anionic surfactant is one or more than two of C8-C16 long carbon chain sulfate, sulfonate, benzene sulfonate and toluene sulfonate.
9. The peroxyacetic acid disinfectant of claim 1, wherein: the long carbon chain carboxylic acid is one or more than two of C8-C16 long carbon chain carboxylic acid n-octanoic acid, iso-octanoic acid, n-nonanoic acid, n-decanoic acid, dodecanoic acid and hexadecanoic acid, preferably one or more than two of n-octanoic acid, n-decanoic acid and dodecanoic acid.
10. The peroxyacetic acid disinfectant of claim 1, wherein: the water requirement meets the water standard of more than three levels GB/T6682-2008.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112913840A (en) * | 2021-01-06 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Ultralow-temperature peracetic acid disinfectant and preparation method thereof |
| CN113367152A (en) * | 2021-05-31 | 2021-09-10 | 山东消博士消毒科技股份有限公司 | Low-temperature peroxyacetic acid disinfectant and preparation method thereof |
| CN115486453A (en) * | 2021-11-02 | 2022-12-20 | 上海柯珑清洁技术有限公司 | Monobasic peroxide bactericide and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0945403A1 (en) * | 1998-03-23 | 1999-09-29 | Degussa-Hüls Aktiengesellschaft | Method for controlling plant pathogenic micro-organisms in greenhouse water circuits. |
| CN103843817A (en) * | 2012-12-06 | 2014-06-11 | 夏美洲 | Hydrogen peroxide and peracetic acid mixed disinfectant and preparation method thereof |
| CN105039987A (en) * | 2015-08-18 | 2015-11-11 | 广东富行洗涤剂科技有限公司 | Stainless steel etching solution composition |
| CN105968052A (en) * | 2016-05-04 | 2016-09-28 | 辽宁科技学院 | Imidazoline corrosion inhibitor and preparation method thereof |
| CN106614584A (en) * | 2016-12-01 | 2017-05-10 | 广东环凯微生物科技有限公司 | Compound peroxycarboxylic acid disinfection solution and preparation method thereof |
| EP3175710A1 (en) * | 2007-08-30 | 2017-06-07 | Ecolab INC. | Shelf stable reduced corrosion, ready to use peroxycarboxylic acid antimicrobial compositions |
| CN106857513A (en) * | 2017-01-11 | 2017-06-20 | 北京长江脉医药科技有限责任公司 | A kind of unitary Peracetic acid solid particle disinfectant |
-
2020
- 2020-03-18 CN CN202010192876.6A patent/CN111226978A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0945403A1 (en) * | 1998-03-23 | 1999-09-29 | Degussa-Hüls Aktiengesellschaft | Method for controlling plant pathogenic micro-organisms in greenhouse water circuits. |
| EP3175710A1 (en) * | 2007-08-30 | 2017-06-07 | Ecolab INC. | Shelf stable reduced corrosion, ready to use peroxycarboxylic acid antimicrobial compositions |
| CN103843817A (en) * | 2012-12-06 | 2014-06-11 | 夏美洲 | Hydrogen peroxide and peracetic acid mixed disinfectant and preparation method thereof |
| CN105039987A (en) * | 2015-08-18 | 2015-11-11 | 广东富行洗涤剂科技有限公司 | Stainless steel etching solution composition |
| CN105968052A (en) * | 2016-05-04 | 2016-09-28 | 辽宁科技学院 | Imidazoline corrosion inhibitor and preparation method thereof |
| CN106614584A (en) * | 2016-12-01 | 2017-05-10 | 广东环凯微生物科技有限公司 | Compound peroxycarboxylic acid disinfection solution and preparation method thereof |
| CN106857513A (en) * | 2017-01-11 | 2017-06-20 | 北京长江脉医药科技有限责任公司 | A kind of unitary Peracetic acid solid particle disinfectant |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112913840A (en) * | 2021-01-06 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Ultralow-temperature peracetic acid disinfectant and preparation method thereof |
| CN113367152A (en) * | 2021-05-31 | 2021-09-10 | 山东消博士消毒科技股份有限公司 | Low-temperature peroxyacetic acid disinfectant and preparation method thereof |
| CN115486453A (en) * | 2021-11-02 | 2022-12-20 | 上海柯珑清洁技术有限公司 | Monobasic peroxide bactericide and preparation method thereof |
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