CN113349201A - Ethanol-gel-free no-wash disinfectant and preparation method thereof - Google Patents
Ethanol-gel-free no-wash disinfectant and preparation method thereof Download PDFInfo
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- CN113349201A CN113349201A CN202110757074.XA CN202110757074A CN113349201A CN 113349201 A CN113349201 A CN 113349201A CN 202110757074 A CN202110757074 A CN 202110757074A CN 113349201 A CN113349201 A CN 113349201A
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- ethanol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Abstract
The invention discloses an ethanol gel-free wash-free disinfectant and a preparation method thereof, belonging to the technical field of disinfectants. The alcohol-free hand-washing disinfection gel comprises, by weight, 100 parts of a disinfection and sterilization composition, 0.1-1 part of an accelerant, 0.5-5 parts of a solubilizer, 0.5-1 part of a gel matrix, 0.1-1 part of an aromatic and the balance of deionized water, wherein the pH value of the alcohol-free hand-washing disinfection gel is 5-7; the disinfectant composition is a composition of a cationic quaternary ammonium salt surfactant and a chlorhexidine bactericide. The invention has high killing rate to common pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans and the like, good stability and no stimulation to skin mucosa of a human body.
Description
Technical Field
The invention relates to an ethanol gel-free no-clean disinfectant and a preparation method thereof, belonging to the technical field of disinfectants.
Background
Along with the increasing importance on the aspect of health, disinfectant products are more and more concerned. Wherein, the hand washing-free gel product has the advantages of convenience and rapidness and has wide consumption requirements in various occasions. The disinfectant can be classified into high-efficiency, medium-efficiency and low-efficiency disinfectants according to different killing abilities of microorganisms. The high-efficiency disinfectant mainly comprises peroxyacetic acid, sodium hypochlorite and the like, is poor in stability and strong in skin irritation, and is not suitable for daily household life. Therefore, the hand disinfection wash-free gel used in daily household mainly takes ethanol as a disinfection effective component. The ethanol is used as a middle-effect disinfectant, has good killing effect on common pathogenic bacteria, is cheap and easily available in raw materials, has the advantages of quick drying, refreshing and the like when being prepared into a gel product, and is a main component of most of washing-free gel products for hand disinfection at present.
However, hand-washing free disinfecting gels based on ethanol also have some technical drawbacks. Firstly, the ethanol solution can obtain the maximum sterilization effect at the concentration of 75%, so that the ethanol content in the current ethanol hand-washing-free disinfection gel is generally more than 50%, the gel has the hidden danger of flammability, and the gel is often not allowed to be carried in public transport means such as high-speed rails and airplanes, thereby greatly limiting the application range of the gel. Secondly, some consumers have allergic constitution to ethanol products, and the problems of red and swollen skin and the like can occur after the ethanol products are used, so that the ethanol disinfection gel products are difficult to use. Thirdly, since the solubility of a gel system containing ethanol as a main component is different from that of a water phase, components such as moisturizing and hand protection with low ethanol solubility cannot be added in a formula, and further development of functions such as moisturizing and hand protection in the gel is limited. Therefore, the development of the alcohol-free formula of the no-clean gel type disinfectant has wide application prospect and consumption demand.
The main difficulty of the development of the alcohol-free hand-washing-free disinfection gel lies in that a proper intermediate disinfectant is selected to be compounded with a gel matrix. The intermediate disinfectant represented by quaternary ammonium salt and chlorhexidine has positive charges, and common gel matrixes such as carbomer, carboxymethyl cellulose and the like have negative charges, so that the two components are flocculated and the solution structure is damaged due to the mismatching of the charges. Therefore, no obvious breakthrough is seen at home and abroad in the aspect of selecting proper disinfection components and gel matrixes to carry out formula design.
Disclosure of Invention
The application aims at the defects of the existing no-clean disinfection gel product technology and provides an ethanol-free gel type no-clean disinfectant and a preparation method thereof. The ethanol-free gel type no-wash disinfectant has the characteristics of quick drying, refreshing and no odor, has high killing rate on common pathogenic bacteria, is nontoxic and harmless, and has no stimulation to skin.
The technical scheme of the invention is as follows:
the invention provides an ethanol-free gel type no-clean disinfectant, which comprises 100 parts by weight of a disinfection and sterilization composition 0.1-1 part, an accelerant 0.1-1 part, a solubilizer 0.5-5 parts, a gel matrix 0.5-1 part, 0.1-1 part of an aromatic and the balance of deionized water, wherein the pH of the ethanol-free gel type no-clean disinfectant is 5-7; the disinfectant composition is a composition of a cationic quaternary ammonium salt surfactant and a chlorhexidine bactericide.
In one embodiment of the invention, the cationic quaternary ammonium salt surfactant comprises at least one of benzalkonium chloride, benzalkonium bromide, dodecyltrimethylammonium chloride, dodecyltrimethylammonium bromide, dodecyl-dimethyl-2-phenoxyethylammonium bromide, tetradecyltrimethylammonium chloride, tetradecyltrimethylammonium bromide, tetradecyldimethylbenzylammonium chloride, tetradecyldimethylbenzylammonium bromide, dioctyldimethylammonium chloride, dioctyldimethylammonium bromide, didecyldimethylammonium chloride, didecyldimethylammonium bromide, didodecyldimethylammonium chloride, ditetradecyldimethylammonium chloride, and ditetradecyldimethylammonium bromide.
In one embodiment of the present invention, the chlorhexidine based biocide comprises at least one of chlorhexidine acetate, chlorhexidine gluconate.
In one embodiment of the present invention, the addition of the accelerator can improve the disinfection effect of the disinfection and sterilization composition, and specifically, the accelerator comprises at least one of urea, hydroxyethyl urea and 1, 3-propylene glycol.
In one embodiment of the present invention, the solubilizer is a nonionic surfactant and is at least one of twelve-carbon or thirteen-carbon fatty alcohol-polyoxyethylene ether (containing 2-9 polyoxyethylene groups), hydrogenated castor oil polyoxyethylene ether, cocamidopropyl betaine and alkyl glycoside.
In one embodiment of the present invention, the gel matrix is at least one of methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, chitosan.
In one embodiment of the present invention, the adjustment of the ethanol-free gel-type no-clean disinfectant is performed by using a pH adjuster, wherein the pH adjuster is an amine organic base or a basic amino acid which does not contain metal ions and is soluble in water, and preferably at least one of triethanolamine, monoethanolamine, ethylenediamine and arginine.
The second object of the present invention is to provide a method for preparing the ethanol-free gel-type leave-on disinfectant, which comprises the steps of:
(1) 0.1-1 part of a detoxication bactericide, wherein the mass ratio of the cationic quaternary ammonium surfactant to the chlorhexidine bactericide is 10:1-1:1, and the detoxication bactericide, the aromatic and the solubilizer are fully stirred until the mixture is uniformly mixed;
(2) adding 50-90 parts of deionized water into the product obtained in the step (1), stirring while adding, and fully dissolving all the components until the solution is uniform, clear and free of insoluble substances;
(3) heating the product obtained in the step (2) to 50 DEGoKeeping the temperature above C, adding 0.5-1 part of gel matrix, and gradually cooling to 40 deg.C under stirringoC, keeping the stirring speed at 120-250 rpm until gel is formed;
(4) and (3) adding 0.1-1 part of accelerator and a proper amount of pH regulator into the product obtained in the step (3) to adjust the pH of the solution to 5-7, adding deionized water to enable the mass part of the system to reach 100 parts, and continuously stirring until the system is transparent and uniform, thus obtaining the ethanol-free gel type no-clean disinfectant.
It is a third object of the present invention to provide a disinfectant article comprising the above ethanol gel-free type leave-on disinfectant.
The fourth purpose of the invention is to provide the application of the ethanol-free gel type no-clean disinfectant in the field of daily chemicals.
The beneficial technical effects of the invention are as follows:
1. the invention has high killing rate to common pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans and the like.
2. The gel type disinfectant prepared by the invention is transparent and colorless, is quick to dry and cool, and can be dried in the air after being used for 1 min.
3. The gel type disinfectant prepared by the invention has high safety, no toxicity or harm and no stimulation to skin mucosa of a human body.
Detailed Description
The present invention will be described in detail with reference to examples.
Example 1
Fully mixing and stirring 0.1 g of benzalkonium chloride, 0.01 g of chlorhexidine acetate, 0.1 g of aromatic and 0.5 g of solubilizer hydrogenated castor oil polyoxyethylene ether, adding 80 g of deionized water while stirring, and stirring until the solution is uniform and transparent; heating the solution to 65 deg.CoC, keeping the temperature, adding 0.75 g of hydroxyethyl cellulose, stirring, gradually cooling to room temperature under stirring, and keeping the stirring speed at 120 revolutions per minute until transparent and uniform gel is formed and the hydroxyethyl cellulose is free from agglomeration; adding 0.5 g of 1, 3-propylene glycol and 0.5 g of hydroxyethyl urea into the system, stirring uniformly, adding deionized water until the total mass is 100g, and continuously stirring for 5 minutes until the system is transparent and uniform to obtain the gel type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is more than 5 for escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is more than 4 for candida albicans.
Example 2
Fully mixing and stirring 0.1 g of didecyl dimethyl ammonium chloride, 0.1 g of chlorhexidine gluconate, 0.1 g of an aromatic and 0.5 g of a solubilizer, namely cocoamidopropyl betaine (CAB), adding 90 g of deionized water while stirring, and stirring until the solution is uniform and transparent; heating the solution to 70 deg.CoC, keeping the temperature, adding 0.8 g of hydroxypropyl methyl cellulose, stirring, gradually cooling to room temperature under stirring, and keeping the stirring speed at 200 revolutions per minute until transparent and uniform gel is formed and the gel matrix is free of agglomeration; adding 0.25 g of hydroxyethyl urea into the system, stirring uniformly, adding deionized water, adjusting the pH to 6.5 by using a very small amount of 10% arginine solution, and continuously stirring for 5 minutes until the system is finishedTransparent and uniform, and the total mass is 100g, thus obtaining the gel type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is more than 5 for escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is more than 4 for candida albicans.
Example 3
0.15 g of benzalkonium chloride, 0.03 g of chlorhexidine gluconate, 0.2 g of an aromatic, 0.5 g of polyoxyethylene dodecyl carbonate (AEO)2) Fully mixing and stirring, adding 50 g of deionized water while stirring, and stirring until the solution is uniform and transparent; heating the solution to 70 deg.CoC, keeping the temperature, adding 0.6 g of hydroxypropyl methyl cellulose, stirring, gradually cooling to room temperature under stirring, and keeping the stirring speed at 200 revolutions per minute until transparent and uniform gel is formed and the gel matrix is free of agglomeration; adding 1 g of urea into the system, stirring uniformly, adding deionized water and a small amount of 10% triethanolamine solution, adjusting the pH to 7.0, wherein the total mass is 100g, and continuously stirring for 5 minutes until the system is transparent and uniform, thus obtaining the gel type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is more than 5 for escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is more than 4 for candida albicans.
Example 4
Fully mixing and stirring 0.2 g of didodecyldimethylammonium chloride, 0.1 g of chlorhexidine acetate, 0.1 g of aromatic and 0.5 g of solubilizer cocoamidopropyl betaine (CAB), adding 90 g of deionized water while stirring, and stirring until the solution is uniform and transparent; heating the solution to 70 deg.CoC, keeping the temperature, adding 0.8 g of hydroxypropyl methyl cellulose, stirring, gradually cooling to room temperature under stirring, and keeping the stirring speed at 250 revolutions per minute until transparent and uniform gel is formed and the gel matrix is free of agglomeration; adding 0.25 g of hydroxyethyl urea into the system, uniformly stirring, adding deionized water, adjusting the pH to 6.0 by using a trace amount of 10% arginine solution, and continuously stirring for 5 minutes until the system is transparent and uniform, wherein the total mass is 100g, thereby obtaining the gel type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is more than 5 for escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is more than 4 for candida albicans.
Comparative example 1
The chlorhexidine acetate in example 1 was changed to benzalkonium chloride, and the gel type disinfectant was prepared using the same composition and procedure as in example 1.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is between 4 and 5 to escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is between 3 and 4 to candida albicans. Therefore, only the quaternary ammonium salt is used as the disinfectant, and the disinfectant and bactericidal effect is not better than that of the disinfectant and bactericidal composition provided by the invention.
Comparative example 2
The accelerator hydroxyethyl urea in example 1 was replaced with deionized water, and the remaining composition and operation procedure were the same as in example 1 to prepare a gel-type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is between 4 and 5 to escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is between 3 and 4 to candida albicans. This shows that the addition of the accelerant can improve the sterilizing effect of the sterilizing composition.
Comparative example 3
The accelerator hydroxyethyl urea in example 1 was replaced with glycerin, and the remaining composition and operation procedure were the same as in example 1, to prepare a gel-type disinfectant.
The use effect is as follows:
the sterilization efficiency is tested by a standard suspension method, the killing logarithm of the antibacterial agent is between 4 and 5 to escherichia coli and staphylococcus aureus, and the killing logarithm of the antibacterial agent is between 3 and 4 to candida albicans.
As can be seen from comparison between example 1 and comparative example 3, when a conventional polyol (glycerin) is used in place of the accelerator listed in the present invention, it was found that the addition of glycerin does not exhibit a similar accelerating effect on the disinfecting composition, indicating that the accelerator listed in the present invention has a unique effect of accelerating the disinfecting effect of the disinfecting composition.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. The ethanol-free gel type no-clean disinfectant is characterized in that 100 parts by weight of the ethanol-free gel type no-clean disinfectant comprises 0.1-1 part of a disinfection and sterilization composition, 0.1-1 part of an accelerant, 0.5-5 parts of a solubilizer, 0.5-1 part of a gel matrix, 0.1-1 part of an aromatic and the balance of deionized water, wherein the pH value of the ethanol-free gel type no-clean disinfectant is 5-7; the disinfectant composition is a composition of a cationic quaternary ammonium salt surfactant and a chlorhexidine bactericide.
2. The ethanol-free gel-type leave-on disinfectant according to claim 1, wherein the cationic quaternary ammonium surfactant comprises at least one of benzalkonium chloride, benzalkonium bromide, dodecyltrimethylammonium chloride, dodecyltrimethylammonium bromide, dodecyl-dimethyl-2-phenoxyethylammonium bromide, tetradecyltrimethylammonium chloride, tetradecyltrimethylammonium bromide, tetradecyldimethylbenzylammonium chloride, tetradecyldimethylbenzylammonium bromide, dioctyldimethylammonium chloride, dioctyldimethylammonium bromide, didecyldimethylammonium chloride, didecyldimethylammonium bromide, didodecyldimethylammonium chloride, ditetradecyldimethylammonium chloride, and ditetradecyldimethylammonium bromide.
3. The ethanol-free gel-type leave-on disinfectant as claimed in claim 1, wherein the chlorhexidine-based bactericide includes at least one of chlorhexidine acetate and chlorhexidine gluconate.
4. The ethanol-free gel-type no-clean disinfectant as claimed in claim 1, wherein the accelerator comprises at least one of urea, hydroxyethyl urea, and 1, 3-propanediol.
5. The ethanol-free gel-type no-clean disinfectant as claimed in claim 1, wherein the solubilizer is a nonionic surfactant, preferably at least one of lauryl alcohol polyoxyethylene ether or tridecyl alcohol polyoxyethylene ether, hydrogenated castor oil polyoxyethylene ether, cocamidopropyl betaine and alkyl glycoside.
6. The ethanol-free gel-type leave-in disinfectant as claimed in claim 1, wherein the gel matrix is at least one of methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and chitosan.
7. The ethanol-free gel-type no-clean disinfectant as claimed in claim 1, wherein the adjustment of the ethanol-free gel-type no-clean disinfectant is performed by using a pH regulator, and the pH regulator is an amine organic base or a basic amino acid which does not contain metal ions and is soluble in water.
8. A method of preparing an ethanol-free gel-type leave-on disinfectant as claimed in any one of claims 1 to 7, said method comprising the steps of:
(1) 0.1-1 part of a detoxication bactericide, wherein the mass ratio of the cationic quaternary ammonium surfactant to the chlorhexidine bactericide is 10:1-1:1, and the detoxication bactericide, the aromatic and the solubilizer are fully stirred until the mixture is uniformly mixed;
(2) adding 50-90 parts of deionized water into the product obtained in the step (1), stirring while adding, and fully dissolving all the components until the solution is uniform, clear and free of insoluble substances;
(3) heating the product obtained in the step (2) to 50 DEGoKeeping the temperature above C, adding 0.5-1 part of gel matrix, and gradually cooling to 40 deg.C under stirringoC below, keeping stirringAt a rate of 120-;
(4) and (3) adding 0.1-1 part of accelerator and a proper amount of pH regulator into the product obtained in the step (3) to adjust the pH of the solution to 5-7, adding deionized water to enable the mass part of the system to reach 100 parts, and continuously stirring until the system is transparent and uniform, thus obtaining the ethanol-free gel type no-clean disinfectant.
9. A disinfectant comprising the ethanol gel-free no-clean disinfectant as claimed in any one of claims 1 to 7.
10. Use of the ethanol-free gel-type no-clean disinfectant as defined in any one of claims 1 to 7 in the field of daily chemicals.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110757074.XA CN113349201A (en) | 2021-07-05 | 2021-07-05 | Ethanol-gel-free no-wash disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110757074.XA CN113349201A (en) | 2021-07-05 | 2021-07-05 | Ethanol-gel-free no-wash disinfectant and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114569473A (en) * | 2022-02-10 | 2022-06-03 | 士露洁家化(武汉)有限公司 | Environment-friendly washing-free antibacterial gel and preparation method thereof |
| CN114984077A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Alcohol-free washing-free disinfection gel and preparation method thereof |
| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135302A (en) * | 2020-01-17 | 2020-05-12 | 稳领(天津)医学科技有限公司 | Hand-washing-free disinfection gel and preparation method thereof |
| CN112494348A (en) * | 2019-09-16 | 2021-03-16 | 上海和黄白猫有限公司 | Antibacterial no-clean hand sanitizer and preparation method and application thereof |
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2021
- 2021-07-05 CN CN202110757074.XA patent/CN113349201A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494348A (en) * | 2019-09-16 | 2021-03-16 | 上海和黄白猫有限公司 | Antibacterial no-clean hand sanitizer and preparation method and application thereof |
| CN111135302A (en) * | 2020-01-17 | 2020-05-12 | 稳领(天津)医学科技有限公司 | Hand-washing-free disinfection gel and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114569473A (en) * | 2022-02-10 | 2022-06-03 | 士露洁家化(武汉)有限公司 | Environment-friendly washing-free antibacterial gel and preparation method thereof |
| CN114569473B (en) * | 2022-02-10 | 2024-02-02 | 士露洁家化(武汉)有限公司 | Environment-friendly wash-free antibacterial gel and preparation method thereof |
| CN114984077A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Alcohol-free washing-free disinfection gel and preparation method thereof |
| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
| CN116898742B (en) * | 2023-09-13 | 2023-12-22 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
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