CN112168730A - Alcohol-free guanidine washing-free disinfectant and preparation method thereof - Google Patents
Alcohol-free guanidine washing-free disinfectant and preparation method thereof Download PDFInfo
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- CN112168730A CN112168730A CN202011007449.2A CN202011007449A CN112168730A CN 112168730 A CN112168730 A CN 112168730A CN 202011007449 A CN202011007449 A CN 202011007449A CN 112168730 A CN112168730 A CN 112168730A
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- disinfectant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses an alcohol-free guanidine no-clean disinfectant, which comprises guanidine disinfectant, ammonium salt disinfectant, preservative, emollient, softener, solubilizer, cleaning agent and water, wherein the guanidine disinfectant comprises one or more of chlorhexidine acetate, chlorhexidine gluconate and polyhexamethylene biguanide salt; the ammonium salt disinfectant comprises one or more of benzalkonium chloride, benzalkonium bromide and laurylamine dipropylenediamine; the water includes deionized water. The guanidine disinfectant and the ammonium salt disinfectant are selected to replace the traditional disinfectant ethanol, so that the disinfectant has no pungent smell and high skin affinity, the problems of heavy odor, poor skin affinity and inconvenience in carrying of the alcohol disinfectant are solved while the sterilization effect is ensured, meanwhile, the guanidine disinfectant has high solubility in water, wide application range and long antibacterial time, and the effective sterilization time of the guanidine no-clean sterilization spray can be prolonged; the preparation method is simple and easy to operate, and the production cost is low.
Description
Technical Field
The invention relates to a disinfectant and a preparation method thereof, in particular to an alcohol-free guanidine washing-free disinfectant and a preparation method thereof.
Background
Ever increasing use of hand disinfection solutions has been made since the outbreaks of new coronavirus pneumonia. The use of the disinfectant can effectively reduce virus infection. The disinfectant liquid can be used in the forms of liquid, spray, foam, etc. The disinfectant used in the spray state is called spray-type hand disinfectant. The spray type hand disinfectant is stored and transported in a liquid state, and when in use, the spray is generated by pressing. The disinfection spray has the advantages of small dosage, large action area, cost saving and the like.
The spray type hand disinfectant is mainly a composition of alcohols, a disinfectant, a softener, a preservative and the like. Ethanol in alcohol is a common solvent and disinfectant, has good bactericidal property, but the sequelae of the sterilizing and disinfecting liquid soap containing alcohol which is frequently used means that the hand skin may have symptoms of allergy, redness, roughness and the like, and the skin is damaged to a certain extent.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to provide an alcohol-free guanidine no-clean disinfectant with high sterilization rate, smoothness and skin friendliness; the second purpose of the invention is to provide a preparation method of the no-clean disinfectant.
The technical scheme is as follows: the alcohol-free guanidine no-clean disinfectant comprises guanidine disinfectant, ammonium salt disinfectant, preservative, emollient, softener, solubilizer, cleaning agent and water, wherein the guanidine disinfectant comprises one or more of chlorhexidine acetate, chlorhexidine gluconate and polyhexamethylene biguanide salt; the ammonium salt disinfectant comprises one or more of benzalkonium chloride, benzalkonium bromide and laurylamine dipropylenediamine; the water includes deionized water.
The components comprise, by weight, 1-5 parts of guanidine disinfectant, 0.08-1 part of ammonium salt disinfectant, 0.04-0.1 part of preservative, 1-3 parts of emollient, 0.1-5 parts of softener, 10-25 parts of solubilizer, 1-3 parts of cleaning agent and 67.7-86.4 parts of deionized water.
Preferably, the preservative comprises phenoxyethanol and sodium benzoate.
Preferably, the emollient includes glycerin and polyoxyethylene glycerol ether.
Preferably, the softener comprises a stearyl alcohol ether.
Preferably, the cleaning agent comprises alkyl alcohol polyoxyethylene ether, cocamidopropyl betaine and cocamidopropyl amine oxide.
Preferably, the solubilizing agents include polyethylene glycol, 1, 2-propanediol, and 1, 2-pentanediol.
The invention relates to a preparation method of an alcohol-free guanidine washing-free disinfectant, which comprises the following steps:
(1) sequentially adding the emollient and the softener into deionized water, and uniformly stirring to obtain a primary solution;
(2) adding a solubilizer into the primary solution, and uniformly stirring to obtain a secondary solution;
(3) sequentially adding guanidine disinfectant and ammonium salt disinfectant into the second-stage solution, uniformly stirring, and adjusting the pH value to 6-8 to obtain a third-stage solution;
(4) and adding a preservative and a cleaning agent into the third-stage solution, and uniformly stirring to obtain a final product.
Has the advantages that: compared with the prior art, the invention has the following remarkable advantages:
(1) the disinfectant disclosed by the invention has the advantages that the guanidine disinfectant and the ammonium salt disinfectant are selected to replace the traditional disinfectant ethanol, no pungent smell is generated, the skin affinity is high, the sterilization effect is ensured, and meanwhile, the problems of heavy smell, poor skin affinity and inconvenience in carrying of the alcohol disinfectant are solved.
(2) The selected guanidine disinfectant has high solubility in water, wide application range, strong disinfection effect and antibacterial effect under low concentration and long antibacterial time, and can prolong the effective sterilization time of the guanidine no-clean disinfection spray.
(3) The ammonium salt disinfectant and the guanidine disinfectant have good synergistic effect, so that the sterilizing effect is further improved, and the mite removing function is realized.
(4) The preparation method is simple and easy to operate, and the production cost is low.
Detailed Description
The technical scheme of the invention is further explained below.
Example 1
In this embodiment, the guanidine disinfectant is 20 wt% chlorhexidine gluconate solution, the ammonium salt disinfectant is 44 wt% benzalkonium chloride solution, the preservative is phenoxyethanol, the emollient is glycerol, the softener is stearyl alcohol ether, the cleaning agent is alkyl alcohol polyoxyethylene ether, and the solubilizer is polyethylene glycol 400.
Taking 1 part of glycerol and 2 parts of stearyl alcohol ether, sequentially adding 83 parts of deionized water, stirring to dissolve completely, adding 10 parts of polyethylene glycol into the system, stirring to dissolve completely, adding 2.5 parts of chlorhexidine gluconate solution and 0.4 part of benzalkonium chloride solution into the system, stirring to dissolve completely, adjusting the pH to 7.0, finally adding 0.1 part of phenoxyethanol and 1 part of alkyl alcohol polyoxyethylene ether into the system, and stirring to dissolve completely to obtain the final product.
Example 2
In this example, the guanidine disinfectant is 20 wt% polyhexamethylene biguanide solution, the ammonium salt disinfectant is 44 wt% benzalkonium bromide solution, the preservative is sodium benzoate, the emollient is glycerol polyoxyethylene ether, the softener is stearyl alcohol ether, the cleaning agent is cocamidopropyl amine oxide, and the solubilizer is 1, 2-propylene glycol.
Taking 1 part of glycerol polyoxyethylene ether and 2 parts of stearyl ether, sequentially adding 81.75 parts of deionized water, stirring to dissolve completely, adding 10 parts of 1, 2-propylene glycol into the system, stirring to dissolve completely, adding 3 parts of polyhexamethylene biguanide solution and 0.2 part of benzalkonium bromide solution into the system, stirring to dissolve completely, adjusting the pH to 6.5, finally adding 0.05 part of phenoxyethanol and 2 parts of cocamidopropyl amine oxide into the system, and stirring to dissolve completely to obtain the final product.
Example 3
In this example, the guanidine disinfectant is 20 wt% chlorhexidine acetate solution, the ammonium salt disinfectant is 90 wt% laurylamine dipropylene diamine solution, the preservative is phenoxyethanol, the emollient is glycerol polyoxyethylene ether, the softener is stearyl alcohol ether, the cleaning agent is cocamidopropyl betaine, and the solubilizer is 1, 2-pentanediol.
Taking 3 parts of glycerol polyoxyethylene ether and 2 parts of stearyl ether, sequentially adding 65.32 parts of deionized water, stirring to dissolve completely, adding 22 parts of 1, 2-pentanediol into the system, stirring to dissolve completely, adding 5 parts of chlorhexidine acetate solution and 0.6 part of laurylamine dipropylene diamine solution into the system, stirring to dissolve completely and adjusting the pH to 7.5, finally adding 0.08 part of phenoxyethanol and 2 parts of cocamidopropyl betaine into the system, and stirring to dissolve completely to obtain the final product.
Example 4
In this example, the guanidine disinfectant is 20 wt% polyhexamethylene biguanide solution, the ammonium salt disinfectant is 44 wt% benzalkonium chloride solution, the preservative is sodium benzoate, the emollient is glycerol, the softener is stearyl alcohol ether, the cleaning agent is alkyl alcohol polyoxyethylene ether, and the solubilizer is 1, 2-propylene glycol.
Taking 1 part of glycerol and 0.5 part of stearyl alcohol ether, sequentially adding 81.22 parts of deionized water, stirring to dissolve completely, adding 22 parts of 1, 2-propylene glycol into the system, stirring to dissolve completely, adding 2 parts of polyhexamethylene biguanide solution and 0.5 part of benzalkonium chloride solution into the system, stirring to dissolve completely, adjusting the pH to 7.8, finally adding 0.04 part of sodium benzoate and 3 parts of alkyl alcohol polyoxyethylene ether into the system, and stirring to dissolve completely to obtain the final product.
Example 5
In this example, the guanidine disinfectant is 20 wt% chlorhexidine acetate solution, the ammonium salt disinfectant is 90 wt% laurylamine dipropylene diamine solution, the preservative is phenoxyethanol, the emollient is glycerol polyoxyethylene ether, the softener is stearyl alcohol ether, the cleaning agent is cocamidopropyl betaine, and the solubilizer is 1, 2-pentanediol.
Taking 2 parts of glycerol polyoxyethylene ether and 2 parts of stearyl ether, sequentially adding the glycerol polyoxyethylene ether and the stearyl ether into 66.1 parts of deionized water, stirring the mixture to be completely dissolved, adding 25 parts of 1, 2-pentanediol into the system, stirring the mixture to be completely dissolved, adding 1 part of chlorhexidine acetate solution and 0.8 part of laurylamine dipropylene diamine solution into the system, stirring the mixture to be completely dissolved, adjusting the pH value to 7.0, finally adding 0.1 part of phenoxyethanol and 2 parts of cocamidopropyl amine oxide into the system, and stirring the mixture to be completely dissolved to obtain a final product.
Example 6
In this embodiment, the guanidine disinfectant is 20 wt% chlorhexidine gluconate solution, the ammonium salt disinfectant is 44 wt% benzalkonium bromide solution, the preservative is sodium benzoate, the emollient is glycerin, the softener is stearyl alcohol ether, the cleaning agent is alkyl alcohol polyoxyethylene ether, and the solubilizer is 1, 2-propylene glycol.
Taking 3 parts of glycerol and 4 parts of stearyl ether, sequentially adding 83.52 parts of deionized water, stirring for complete dissolution, adding 15 parts of 1, 2-propylene glycol into the system, stirring for complete dissolution, adding 1.5 parts of polyhexamethylene biguanide solution and 0.5 part of benzalkonium bromide solution into the system, stirring for complete dissolution, adjusting the pH to 6.7, finally adding 0.1 part of sodium benzoate and 3 parts of alkyl alcohol polyoxyethylene ether into the system, and stirring for complete dissolution to obtain the final product.
Comparative example 1
Compared with the embodiment 1, the comparative example has no guanidine disinfectant, the dosage of the ammonium salt disinfectant is 0.6 part, and other raw materials, proportioning and operation steps are the same as those of the embodiment 1.
Comparative example 2
Compared with the embodiment 1, the comparative example has the advantages that the quaternary ammonium salt disinfectant is not added, the dosage of the guanidine disinfectant is 3 parts, and other raw materials, proportioning and operation steps are the same as those of the embodiment 1.
Comparative example 3
Compared with the embodiment 1, the dosage of the guanidine disinfectant in the comparative example is 0.5 part, and other raw materials, proportioning and operation steps are the same as those in the embodiment 1.
Comparative example 4
Compared with the example 1, the dosage of the ammonium salt disinfectant in the comparative example is 0.05 part, and other raw materials, proportioning and operation steps are the same as those in the example 1.
Comparative example 5
Compared with the embodiment 1, the comparative example does not add guanidine disinfectant and ammonium salt disinfectant, selects 70 parts of ethanol, and has the same other raw materials, proportion and operation steps as the embodiment 1.
Table 1 studies the synergistic effects of guanidine disinfectants and ammonium salt disinfectants
According to the requirements of GB 27952 and GB 27950, the microbial indexes of the sterilized samples are as follows: sterilization of candida albicans
The logarithm value is not less than 4, and the sterilization logarithm value of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa is not less than 5
As can be seen from Table 1:
(1) compared with the embodiment 1, the comparative example 1 has the advantages that the guanidine disinfectant is not added, only the ammonium salt disinfectant is added, the sterilization performance is greatly reduced, the sterilization effect cannot be achieved, and the skin-friendly performance is also reduced.
(2) Compared with the embodiment 1, the comparative example 2 has the advantages that the sterilizing performance is greatly reduced and the sterilizing effect cannot be achieved by adding only the guanidine disinfectant without adding the ammonium salt disinfectant.
(3) Compared with the example 1, the addition amount of the guanidine disinfectant is reduced to 0.5 part, the sterilization performance is reduced, and the sterilization effect cannot be achieved, so that when the addition amount of the guanidine disinfectant is less than 1 part, the synergistic effect of the guanidine disinfectant and the ammonium salt disinfectant is not obvious, and the sterilization performance is weakened.
(4) In comparative example 4, compared with example 1, when the addition amount of the ammonium salt disinfectant is reduced to 0.05 part, the bactericidal performance is reduced, and the effect of disinfection cannot be achieved, so that when the addition amount of the ammonium salt disinfectant is less than 0.08 part, the synergistic effect of the guanidine disinfectant and the ammonium salt disinfectant is not obvious, and the bactericidal performance is weakened. .
(5) Compared with the example 1, the comparative example 5 has the advantages that the alcohol is used for replacing the ammonium salt disinfectant and the guanidine disinfectant, although the sterilizing performance can achieve the sterilizing effect, the skin friendliness is very poor, the smell is heavy, and the carrying and the use are not facilitated.
Claims (8)
1. An alcohol-free guanidine no-clean disinfectant, which comprises guanidine disinfectant, ammonium salt disinfectant, preservative, emollient, softener, solubilizer, cleaning agent and water, and is characterized in that the guanidine disinfectant comprises one or more of chlorhexidine acetate, chlorhexidine gluconate and polyhexamethylene biguanide salt; the ammonium salt disinfectant comprises one or more of benzalkonium chloride, benzalkonium bromide and laurylamine dipropylenediamine; the water includes deionized water.
2. The alcohol-free guanidine no-clean disinfectant as claimed in claim 1, which comprises guanidine disinfectant 1-5 parts, ammonium salt disinfectant 0.08-1 part, antiseptic 0.04-0.1 part, emollient 1-3 parts, softener 0.1-5 parts, solubilizer 10-25 parts, cleaning agent 1-3 parts and deionized water 57.9-88.58 parts.
3. The alcohol-free guanidine no-clean disinfectant as set forth in claim 1 or 2, wherein the preservative comprises phenoxyethanol and sodium benzoate.
4. The alcohol-free guanidine leave-on disinfectant according to claim 1 or 2, wherein the emollient comprises glycerin and polyoxyethylene glycerol ether.
5. The alcohol-free guanidine leave-in disinfectant according to claim 1 or 2, wherein the softener comprises a stearyl alcohol ether.
6. The alcohol-free guanidine no-clean disinfectant as set forth in claim 1 or 2, wherein the cleaning agent comprises alkyl alcohol polyoxyethylene ether, cocamidopropyl betaine and cocamidopropyl amine oxide.
7. The alcohol-free guanidine leave-in disinfectant according to claim 1 or 2, wherein the solubilizing agent comprises polyethylene glycol, 1, 2-propylene glycol and 1, 2-pentanediol.
8. A method for preparing the alcohol-free guanidine no-clean disinfectant as claimed in claim 1, which comprises the following steps:
(1) sequentially adding the emollient and the softener into deionized water, and uniformly stirring to obtain a primary solution;
(2) adding a solubilizer into the primary solution, and uniformly stirring to obtain a secondary solution;
(3) sequentially adding guanidine disinfectant and ammonium salt disinfectant into the second-stage solution, uniformly stirring, and adjusting the pH value to 6-8 to obtain a third-stage solution;
(4) and adding a preservative and a cleaning agent into the third-stage solution, and uniformly stirring to obtain a final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011007449.2A CN112168730A (en) | 2020-09-23 | 2020-09-23 | Alcohol-free guanidine washing-free disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011007449.2A CN112168730A (en) | 2020-09-23 | 2020-09-23 | Alcohol-free guanidine washing-free disinfectant and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113349199A (en) * | 2021-06-30 | 2021-09-07 | 无锡宏霸医疗科技有限公司 | Foam type ethanol-free washing-free disinfectant |
| CN113456536A (en) * | 2021-07-08 | 2021-10-01 | 四川大学 | Alcohol-free skin-care washing-free disinfectant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731257A (en) * | 2008-11-24 | 2010-06-16 | 兰州益生化工有限公司 | Novel polyhexamethylene guanidine compound disinfectant and preparation method |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
-
2020
- 2020-09-23 CN CN202011007449.2A patent/CN112168730A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731257A (en) * | 2008-11-24 | 2010-06-16 | 兰州益生化工有限公司 | Novel polyhexamethylene guanidine compound disinfectant and preparation method |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113349199A (en) * | 2021-06-30 | 2021-09-07 | 无锡宏霸医疗科技有限公司 | Foam type ethanol-free washing-free disinfectant |
| CN113456536A (en) * | 2021-07-08 | 2021-10-01 | 四川大学 | Alcohol-free skin-care washing-free disinfectant and preparation method thereof |
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Application publication date: 20210105 |