CN112515996B - Antibacterial hand sanitizer and preparation method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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Abstract
The application provides a bacteriostatic hand sanitizer and a method for preparing the same. The antibacterial hand sanitizer comprises the following components based on the total weight: 0.1-0.5 wt% of a cationic antibacterial agent; 1-10 wt% of a glycoside surfactant; 0.5-5 wt% of an ethoxylated alcohol surfactant; 1-5 wt% of a humectant; 0.1-0.6 wt% of an alcohol preservative; and the balance water. According to the technical scheme, the hand sanitizer with good cleaning effect, comfortable hand feeling after cleaning and good bacteria killing effect can be provided.
Description
Technical Field
The application relates to the technical field of cleaning, and in particular provides an antibacterial hand sanitizer and a preparation method thereof.
Background
Hand washing is an important ring in daily life to maintain personal hygiene. Meanwhile, hand washing is also a frequently repeated operation required by hospital staff, which is important to prevent or reduce cross infection of related diseases in hospitals. There are a wide variety of hand sanitizer products currently on the market. At present, the requirements for hand sanitizers are gradually increased, and the hand sanitizers are required to provide good effects in terms of cleaning effect, hand feeling after cleaning and the like, and meanwhile, the hand sanitizers are required to have an effective antibacterial effect.
Therefore, developing a hand sanitizer with good cleaning effect, comfortable hand feeling after cleaning and good bacteria killing effect has important significance.
Disclosure of Invention
Based on the technical problems set forth above, the application aims to provide a hand sanitizer with good cleaning effect, comfortable hand feeling after cleaning and good bacteria killing effect and a preparation method thereof. The present inventors have conducted intensive studies to complete the present application.
According to one aspect of the present application there is provided a bacteriostatic hand wash comprising, based on its total weight:
0.1-0.5 wt% of a cationic antibacterial agent;
1-10 wt% of a glycoside surfactant;
0.5-5 wt% of an ethoxylated alcohol surfactant;
1-5 wt% of a humectant;
0.1-0.6 wt% of an alcohol preservative; and
the balance of water.
According to another aspect of the present application there is provided a process for preparing a bacteriostatic hand wash comprising mixing the components of the bacteriostatic hand wash as described above.
The hand sanitizer provided by the application has good cleaning effect and comfortable hand feeling after cleaning, and has an effective killing effect on escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and the like.
Detailed Description
It is to be understood that other various embodiments can be devised and modifications to the embodiments by those skilled in the art based on the teachings herein without departing from the scope or spirit of this disclosure. The following detailed description is, therefore, not to be taken in a limiting sense.
All numbers expressing feature sizes, amounts, and physical and chemical characteristics used in the specification and claims are to be understood as being modified in all instances by the term "about" unless otherwise indicated. Accordingly, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and attached claims are approximations that can be varied appropriately by those skilled in the art utilizing the desired properties sought to be obtained by the teachings disclosed herein. The use of numerical ranges by endpoints includes all numbers subsumed within that range and any range within that range, e.g., 1 to 5 includes 1, 1.1, 1.3, 1.5, 2, 2.75, 3, 3.80, 4, 5, and the like.
Currently, with development and application of hand sanitizer products, the technical requirements on the hand sanitizer products are higher and higher, and the hand sanitizer products are expected to have good hand feeling after cleaning and effective killing effects on various common bacteria while having good cleaning effects. Currently, the most common commercial bacteriostatic hand sanitizer products typically contain quaternary ammonium salt based antimicrobial agents, betaine, glycerin, and Kathon (Kathon) CG, among others. The inventors of the present application have found that these commercial bacteriostatic hand sanitizer products comprising the above components are not yet satisfactory in terms of cleaning and antibacterial efficacy, among other things. For example, although these products have some killing effect on E.coli, staphylococcus aureus and Pseudomonas aeruginosa, they have no obvious killing effect on Candida albicans, which is common in daily life. The inventor of the present application found in the research that by adopting a combination of a specific content of a cationic antibacterial agent, a glycoside surfactant, an ethoxylated alcohol surfactant, a humectant, an alcohol preservative and water, a hand sanitizer having a good cleaning effect, a comfortable hand feeling after cleaning and a good bacterial killing effect on bacteria (especially escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, etc.) which are common in life can be provided.
Antibacterial hand sanitizer
Certain aspects of the present application provide an antibacterial hand sanitizer comprising, based on total weight thereof:
0.1-0.5 wt% of a cationic antibacterial agent;
1-10 wt% of a glycoside surfactant;
0.5-5 wt% of an ethoxylated alcohol surfactant;
1-5 wt% of a humectant;
0.1-0.6 wt% of an alcohol preservative; and
the balance of water.
Cationic antibacterial agent
The antibacterial hand sanitizer according to the present application comprises a cationic antibacterial agent as an essential component. The main function of the cationic antibacterial agent is to kill various common bacteria. The specific type of the cationic antibacterial agent that can be used in the present application is not particularly limited as long as it can provide an appropriate bactericidal effect. Preferably, the cationic antibacterial agent is selected from one or more of quaternary ammonium salt antibacterial agents and guanidine antibacterial agents. More preferably, the cationic antibacterial agentThe agent is selected from C 12 -C 18 Alkyl dimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl dimethyl benzyl ammonium bromide, C 12 -C 18 Alkyl trimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl trimethyl benzyl ammonium bromide, C 8 -C 18 Dialkyl dimethyl ammonium chloride, C 8 -C 18 One or more of the group consisting of dialkyldimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, polyhexamethylene monoguanidine, polyhexamethylene biguanidine, and the like. The content of the cationic antibacterial agent is 0.1-0.5 wt% based on the total weight of the antibacterial hand sanitizer. Commercially available products of cationic antibacterial agents that can be used in the present application include, for example: benzalkonium chloride (product name: barquat DM-50) manufactured by Lonza Corp; benzisotrichia (product name: lonzagard) produced by Lonza Corp TM ) The method comprises the steps of carrying out a first treatment on the surface of the And polyhexamethylene biguanide (product name: PHMB) produced by Lonza corporation.
Glycoside surfactant
The antibacterial hand cleanser according to the present application contains a glycoside surfactant as an essential component. The glycoside surfactant plays a role in promoting bacteria adsorption and neutralizing charges in the system. The glycoside surfactant and the ethoxylated alcohol surfactant can synergistically act to improve the bacterial killing effect of the antibacterial hand sanitizer. Preferably, the glycoside surfactant is C 8-12 Alkyl glycosides. More preferably, the glycoside surfactant is C 8-12 Alkyl glucosides. The content of the glycoside surfactant is 1-10 wt%, preferably 1-5 wt%, based on the total weight of the antibacterial hand sanitizer. Commercially available products of the glycoside surfactant which can be used in the present application include, for example: c produced by BASF corporation 10-12 Alkyl glucosides (product name:2000 UP); and C produced by BASF corporation 12-16 Alkyl glucosides (product name:>1200UP)。
ethoxylated alcohol surfactant
The antibacterial hand sanitizer according to the present application comprises an ethoxylated alcohol surfactant as another essential surfactant. The ethoxylated alcohol surfactant and the glycoside surfactant can synergistically act to improve the bacteria killing effect of the antibacterial hand sanitizer. Preferably, the ethoxylated alcohol surfactant is an ethoxylated C 9-18 An alcohol. More preferably, the ethoxylated alcohol surfactant is selected from the group consisting of ethoxylated C 9-11 Alcohol, ethoxylated C 10-14 Alcohol, ethoxylated C 12-18 Alcohol and ethoxylation C 16-18 Alcohols, and the like. The content of the ethoxylated alcohol surfactant is 0.5-5 wt% based on the total weight of the antibacterial hand sanitizer. Commercially available products of ethoxylated alcohol surfactants which can be used in the present application are, for example, ethoxylated C produced by Envonic company 9-11 Alcohol (product name: TOMAKLEEN G-12).
Humectant type
The antibacterial hand sanitizer according to the application comprises a humectant as an essential component. The humectant can improve the wettability of the antibacterial hand sanitizer to skin. Preferably, the humectant is selected from one or more of the group consisting of glycerol polyether, glycerol, propylene glycol, hyaluronic acid, sorbic acid, polyethylene glycol and the like. More preferably, the humectant is a glycerol polyether. The humectant content is 1-5 wt% based on the total weight of the antibacterial hand sanitizer. Commercially available products of humectants that can be used in the present application are, for example, glycereth-26 (RENEX, manufactured by the CRODA company TM G26-LQ-(RB))。
Alcohol preservative
The antibacterial hand sanitizer according to the present application comprises an amount of an alcohol preservative. Preferably, the alcohol preservative is selected from one or more of the group consisting of phenoxyethanol, benzyl alcohol and phenethyl alcohol. The content of the alcohol preservative is 0.1-0.6 wt% based on the total weight of the antibacterial hand sanitizer. Commercially available products of alcohol preservatives that may be used in the present application include, for example: phenoxyethanol (product name: troyCare POE) manufactured by TROY Co
Other components
One or more other components may also optionally be included in the antibacterial hand sanitizer according to the present application to achieve various functions. Preferably, the antibacterial hand sanitizer further comprises one or more of the group consisting of foam stabilizer, essence, colorant and the like. The specific types of foam stabilizers, fragrances, colorants, etc. that can be used in the present application and the content thereof are not particularly limited, and may be appropriately selected and added without affecting the cleaning, antibacterial, etc. effects of the antibacterial hand sanitizer according to the present application.
Water and its preparation method
In the antibacterial hand sanitizer according to the application, the water is a solvent in the antibacterial hand sanitizer. The specific content of water is not particularly limited as long as the above-mentioned cationic antibacterial agent, glycoside surfactant, ethoxylated alcohol surfactant, moisturizer, alcohol preservative and optional other components can be sufficiently dissolved or dispersed and adjusted to a degree suitable for hand washing application.
Method for preparing antibacterial hand sanitizer
The specific method for preparing the antibacterial hand sanitizer according to the present application is not particularly limited, and mixing methods generally employed in the art may be employed. Specifically, the individual components of the antibacterial hand sanitizer described above may be dissolved or dispersed together in water, depending on their particular amounts.
The description of each component of the antibacterial hand sanitizer is detailed in the section of the antibacterial hand sanitizer.
The following detailed description is intended to illustrate the disclosure by way of example and not by way of limitation.
Embodiment 1 is an antibacterial hand sanitizer, comprising, based on the total weight thereof:
0.1-0.5 wt% of a cationic antibacterial agent;
1-10 wt% of a glycoside surfactant;
0.5-5 wt% of an ethoxylated alcohol surfactant;
1-5 wt% of a humectant:
0.1-0.6 wt% of an alcohol preservative; and
the balance of water.
Embodiment 2 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the cationic antibacterial agent is selected from one or more of quaternary ammonium salt antibacterial agents and guanidine antibacterial agents.
Embodiment 3 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the cationic antibacterial agent is selected from the group consisting of C 12 -C 18 Alkyl dimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl dimethyl benzyl ammonium bromide, C 12 -C 18 Alkyl trimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl trimethyl benzyl ammonium bromide, C 8 -C 18 Dialkyl dimethyl ammonium chloride, C 8 -C 18 One or more of the group consisting of dialkyldimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, polyhexamethylene monoguanidine, and polyhexamethylene biguanide.
Embodiment 4 is the bacteriostatic hand sanitizer according to embodiment 1, wherein the glycoside surfactant is C 8-12 Alkyl glycosides.
Embodiment 5 is the bacteriostatic hand sanitizer according to embodiment 1, wherein the glycoside surfactant is C 8-12 Alkyl glucosides.
Embodiment 6 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the ethoxylated alcohol surfactant is an ethoxylated C 9-18 An alcohol.
Embodiment 7 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the ethoxylated alcohol surfactant is selected from the group consisting of ethoxylated C 9-11 Alcohol, ethoxylated C 10-14 Alcohol, ethoxylated C 12-18 Alcohol and ethoxylation C 16-18 One or more of the group consisting of alcohols.
Embodiment 8 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the humectant is selected from one or more of the group consisting of glycerol polyether, glycerol, propylene glycol, hyaluronic acid, sorbic acid and polyethylene glycol.
Embodiment 9 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the alcohol preservative is selected from one or more of the group consisting of phenoxyethanol, benzyl alcohol, and phenethyl alcohol.
Embodiment 10 is a bacteriostatic hand sanitizer according to embodiment 1, wherein the alcohol preservative is phenoxyethanol.
Embodiment 11 is the bacteriostatic hand sanitizer of embodiment 1, further comprising one or more of the group consisting of a foam stabilizer, a fragrance, and a colorant.
Embodiment 12 is a method for preparing an antibacterial hand sanitizer, comprising mixing the components of the antibacterial hand sanitizer of any of embodiments 1-11 above.
The present application will be described in more detail with reference to examples. It should be noted that the description and examples are intended to facilitate an understanding of the application and are not intended to limit the application. The scope of the application is defined by the appended claims.
Examples
In the present application, unless otherwise indicated, the reagents employed were all commercially available products and were used directly without further purification treatment.
Test method
In the present disclosure, antibacterial hand sanitizers obtained in the following examples and comparative examples were tested with respect to bactericides, cleanliness, and post-wash hand. The specific test method is described below.
Sterilizing property
Antibacterial hand sanitizers obtained in the following examples and comparative examples were tested for their antibacterial properties with respect to escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa, respectively, with a contact time of 1 minute, with reference to the antibacterial test methods recorded in annex C1-C3 of the national standard GB 15979-2002.
Cleaning property
The cleaning effect of the antibacterial hand sanitizers prepared in the following examples and comparative examples was tested using an STF card (cleaning test card, steris corporation), respectively. Specifically, 2mL of the hand wash was withdrawn and overlaid on the STF card and held for 10 minutes. The level of cleaning effect was then determined by comparing the extent of red soil on the STF card to the left, wherein: the scale removal rate was determined to be level 1 for the cases of 10% or more and less than 30%; determining the scale removal rate to be 30% or more and less than 60% as level 2; determining the scale removal rate to be greater than or equal to 60% and less than 70% as level 3; determining the scale removal rate to be higher than or equal to 70% and lower than 90% as grade 4; and the case where the soil removal rate was 90% or more was determined as level 5. The higher the cleaning performance level, the better the cleaning effect.
Hand feel after cleaning
10 testers were randomly selected to test hand feel properties of the antibacterial hand sanitizers prepared in the following examples and comparative examples. Specifically, the 10 testers performed hand washing operations using the antibacterial hand washing solutions prepared in the following examples and comparative examples, respectively, and scored hand feeling after hand washing in the range of 1 to 10. The higher the score, the better the hand after washing.
The reagents used in the following examples and comparative examples are specifically listed in table 1 below:
TABLE 1
Example 1 (E1)
At a temperature of 25-30deg.C, 0.1g of cationic antibacterial agent BarqQuat DM-50, 1g of glycoside surfactant1200UP, 0.5G ethoxylated alcohol surfactant TOMAKLEEN G-12, 2G humectant RENEX TM G26-LQ- (RB) and 0.1G of an alcohol preservative TroyCare POE were dissolved in 96.3G of deionized water and thoroughly stirred to prepare antibacterial hand sanitizer 1.
The resulting antibacterial hand sanitizer 1 was tested for bactericidal, cleaning, and post-wash hand feel according to the test methods described above, with specific test results shown in tables 4 and 5, respectively, below.
Examples 2 to 9 (E2 to E9) and comparative examples 1 to 11 (C1 to C11)
Examples 2 to 9 (E2 to E9) and comparative examples 1 to 11 (C1 to C11) were prepared in a similar manner to example 1, except that the amounts of the respective components were changed according to the ratios shown in tables 2 and 3 below to obtain antibacterial hand washes.
The antibacterial hand sanitizers obtained in examples 2 to 9 (E2 to E9) and comparative examples 1 to 11 (C1 to C11) were tested according to the test methods described above, respectively, with respect to bactericidal properties, cleaning properties and hand feeling after washing, and specific test results are shown in tables 4 and 5 below, respectively.
Table 4 results of antibacterial tests on antibacterial hand sanitizers prepared in examples 1 to 9 (E1 to E9) and comparative examples 1 to 11 (C1 to C11)
Table 5 cleaning and hand feel test results after cleaning of antibacterial hand sanitizers prepared in examples 1-9 (E1-E9) and comparative examples 1-11 (C1-C11)
| Cleanliness (STF card test) rating | Hand feel grade after washing | |
| Example 1 | Level 3 | 8.0 |
| Example 2 | Level 4 | 9.0 |
| Example 3 | Level 3 | 8.0 |
| Example 4 | Level 4 | 8.5 |
| Example 5 | Level 3 | 8.0 |
| Example 6 | Level 3 | 8.0 |
| Example 7 | Level 3 | 8.0 |
| Example 8 | Level 3 | 8.0 |
| Example 9 | Level 4 | 8.0 |
| Comparative example 1 | Level 2 | 70 |
| Comparative example 2 | Level 2 | 7.5 |
| Comparative example 3 | Level 3 | 7.5 |
| Comparative example 4 | Level 4 | 7.0 |
| Comparative example 5 | Level 3 | 7.5 |
| Comparative example 6 | Level 4 | 7.5 |
| Comparative example 7 | Level 3 | 8.0 |
| Comparative example 8 | Level 1 | 7.5 |
| Comparative example 9 | Level 1 | 7.5 |
| Comparative example 10 | Level 1 | 7.5 |
| Comparative example 11 | Level 1 | 7.5 |
From the test results shown in tables 4 and 5 above, it is understood that when specific amounts of cationic antibacterial agent, glycoside surfactant, ethoxylated alcohol surfactant, humectant, alcohol preservative and water are selected within the scope of the present application to prepare antibacterial hand sanitizer, the obtained antibacterial hand sanitizer has good cleaning effect, comfortable hand feeling after cleaning, and excellent killing effect on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa at the same time (the killing rate of escherichia coli, staphylococcus aureus and pseudomonas aeruginosa is more than 99%, and the killing rate of candida albicans is more than 90%).
As is clear from a comparison between example 1 and comparative example 1, when the glycoside surfactant is not contained in the antibacterial hand sanitizer, the cleaning effect, the hand feeling after washing, and the sterilization effect of the obtained antibacterial hand sanitizer are reduced, and in particular, there is little sterilization effect on candida albicans.
As is clear from a comparison of example 1 with comparative example 2, when the ethoxylated alcohol surfactant is not contained in the antibacterial hand sanitizer, the cleaning effect, the hand feeling after washing, and the sterilization effect of the obtained antibacterial hand sanitizer are reduced, and in particular, there is little sterilization effect on candida albicans.
As is clear from a comparison between example 1 and comparative example 3, when the content (0.08 wt%) of the glycoside surfactant in the antibacterial hand sanitizer is less than the lower limit (1 wt%) specified in the present application, the cleaning effect of the obtained antibacterial hand sanitizer remains substantially unchanged, but the hand feeling and the sterilization effect after cleaning are reduced, and in particular, the sterilization effect against Candida albicans is greatly reduced (reduced to > 50%).
As is clear from a comparison between example 1 and comparative example 4, when the content (12 wt%) of the glycoside surfactant in the antibacterial hand sanitizer is greater than the upper limit value (10 wt%) specified in the present application, the antibacterial effect against Candida albicans is greatly reduced (reduced to > 80%) and the hand feel after washing is poor, although the cleaning effect of the obtained antibacterial hand sanitizer is good.
As is clear from a comparison between example 1 and comparative example 5, when the content of the ethoxylated alcohol surfactant (0.4 wt%) in the antibacterial hand sanitizer is less than the lower limit value (0.5 wt%) specified in the present application, the cleaning effect of the obtained antibacterial hand sanitizer remains substantially unchanged, but the sterilizing effect is lowered and the hand feeling after washing is poor, and in particular, the sterilizing effect against Candida albicans is greatly lowered (reduced to > 50%).
As is clear from a comparison between example 1 and comparative example 6, when the content of the ethoxylated alcohol surfactant (5.5 wt%) in the antibacterial hand sanitizer is greater than the upper limit value (5 wt%) specified in the present application, the obtained antibacterial hand sanitizer is excellent in cleaning effect, but is reduced in sterilizing effect and poor in hand feeling after cleaning, and in particular, the sterilizing effect against Candida albicans is greatly reduced (reduced to > 80%).
As can be seen by comparing example 1 with comparative example 7, when the alcohol preservative phenoxyethanol TroyCare POE in the antibacterial hand sanitizer is replaced with the same amount of isothiazolone preservative Nipguard CG commonly used in the art, the cleaning effect and the hand feeling after cleaning of the obtained antibacterial hand sanitizer are basically maintained, but the killing effect on Escherichia coli, staphylococcus aureus and pseudomonas aeruginosa is greatly reduced to different degrees.
Antibacterial hand sanitizers for comparison were prepared in comparative examples 8-11 from the quaternary ammonium salt type antibacterial agents, betaines, glycerins, and Nipguard CG, etc., components commonly used in the art to prepare hand sanitizers, which are the components commonly included in the most common commercial antibacterial hand sanitizer products. As can be seen from comparing the results of examples 1-9 and comparative examples 8-11, the antibacterial hand sanitizer obtained according to the technical scheme of the application has excellent killing effects on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa (the killing rate on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa is more than 99% and the killing rate on candida albicans is more than 90%) while having good cleaning effect and comfortable hand feeling after cleaning.
Although specific embodiments of the application have been illustrated and described herein, it will be appreciated by those of ordinary skill in the art that a wide variety of alternate and/or equivalent implementations may be substituted for the specific embodiments shown and described without departing from the scope of the present application. This application is intended to encompass any modifications or alterations to the specific embodiments discussed in this application. Therefore, it is intended that this application be limited only by the claims and the equivalents thereof.
It will be understood by those skilled in the art that various modifications and changes may be made without departing from the scope of the present application. Such modifications and variations are intended to fall within the scope of the application as defined in the appended claims.
Claims (10)
1. A bacteriostatic hand sanitizer comprising, based on total weight thereof:
0.1-0.5 wt% of a cationic antibacterial agent;
1-10 wt% of a glycoside surfactant, wherein the glycoside surfactant is C 8-12 Alkyl glucosides or C 12-16 Alkyl glucosides;
0.5-5 wt% of an ethoxylated alcohol surfactant;
1-5 wt% of a humectant;
0.1-0.6 wt% of an alcohol preservative; and
the balance of water.
2. The antibacterial hand sanitizer of claim 1 wherein the cationic antibacterial agent is selected from one or more of quaternary ammonium salt antibacterial agents and guanidine antibacterial agents.
3. The bacteriostatic hand sanitizer according to claim 1, wherein the cationic antibacterial agent is selected from the group consisting of C 12 -C 18 Alkyl dimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl dimethyl benzyl ammonium bromide, C 12 -C 18 Alkyl trimethyl benzyl ammonium chloride, C 12 -C 18 Alkyl trimethyl benzyl ammonium bromide, C 8 -C 18 Dialkyl dimethyl ammonium chloride, C 8 -C 18 One or more of the group consisting of dialkyldimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, polyhexamethylene monoguanidine, and polyhexamethylene biguanide.
4. The bacteriostatic hand sanitizer according to claim 1, wherein the ethoxylated alcohol surfactant is an ethoxylated C 9-18 An alcohol.
5. The bacteriostatic hand sanitizer according to claim 1, wherein the ethoxylated alcohol surfactant is selected from the group consisting of ethoxylated C 9-11 Alcohol, ethoxylated C 10-14 Alcohol, ethoxylated C 12-18 Alcohol and ethoxylation C 16-18 One or more of the group consisting of alcohols.
6. The bacteriostatic hand sanitizer according to claim 1, wherein the humectant is selected from one or more of the group consisting of glycerol polyether, glycerol, propylene glycol, hyaluronic acid, sorbic acid and polyethylene glycol.
7. The bacteriostatic hand sanitizer according to claim 1, wherein the alcohol preservative is selected from one or more of the group consisting of phenoxyethanol, benzyl alcohol and phenethyl alcohol.
8. The bacteriostatic hand sanitizer according to claim 1, wherein the alcohol preservative is phenoxyethanol.
9. The bacteriostatic hand sanitizer according to claim 1, further comprising one or more of the group consisting of foam stabilizers, fragrances and colorants.
10. A process for preparing a bacteriostatic hand sanitizer comprising mixing the components of a bacteriostatic hand sanitizer according to any of the preceding claims 1-9.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992018100A1 (en) * | 1991-04-15 | 1992-10-29 | The Procter & Gamble Company | Antibacterial mild liquid skin cleanser |
| CN1265582A (en) * | 1997-06-04 | 2000-09-06 | 普罗克特和甘保尔公司 | Mild, rinse-off antimicrobial liquid cleansing compositions |
| CN101018847A (en) * | 2004-09-11 | 2007-08-15 | 雷克特本克斯尔有限公司 | Improvements in or relating to organic compositions |
| CN103520022A (en) * | 2013-10-21 | 2014-01-22 | 广州立白企业集团有限公司 | Antibacterial hand sanitizer and preparation method thereof |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN107496189A (en) * | 2017-09-12 | 2017-12-22 | 衢州瀚心科技有限公司 | Bacteriostatic hand sanitizer and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL190181A (en) * | 2008-03-16 | 2015-08-31 | Altos Medical Llc | Cleaning, sanitising and sterilising preparations |
| EP2830574A2 (en) * | 2012-03-30 | 2015-02-04 | GOJO Industries, Inc. | Cationic antimicrobial handwash |
-
2020
- 2020-11-30 CN CN202011374228.9A patent/CN112515996B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992018100A1 (en) * | 1991-04-15 | 1992-10-29 | The Procter & Gamble Company | Antibacterial mild liquid skin cleanser |
| CN1265582A (en) * | 1997-06-04 | 2000-09-06 | 普罗克特和甘保尔公司 | Mild, rinse-off antimicrobial liquid cleansing compositions |
| CN101018847A (en) * | 2004-09-11 | 2007-08-15 | 雷克特本克斯尔有限公司 | Improvements in or relating to organic compositions |
| CN103520022A (en) * | 2013-10-21 | 2014-01-22 | 广州立白企业集团有限公司 | Antibacterial hand sanitizer and preparation method thereof |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN107496189A (en) * | 2017-09-12 | 2017-12-22 | 衢州瀚心科技有限公司 | Bacteriostatic hand sanitizer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 马振友等.《皮肤美容化妆品制剂手册 第2版》.《皮肤美容化妆品制剂手册 第2版》.中医古籍出版社,2015,第647页. * |
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