CN104082293B - A kind of composite alcohol sterilizing agent and its preparation method - Google Patents
A kind of composite alcohol sterilizing agent and its preparation method Download PDFInfo
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- CN104082293B CN104082293B CN201410340248.2A CN201410340248A CN104082293B CN 104082293 B CN104082293 B CN 104082293B CN 201410340248 A CN201410340248 A CN 201410340248A CN 104082293 B CN104082293 B CN 104082293B
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Abstract
The present invention provides a kind of composite alcohol sterilizing agent and its preparation method, sterilizing agent comprises the raw material of following mass percent concentration: ethanol 20-30%, n-propyl alcohol 30-40%, tensio-active agent 0.2-2%, composite additive 0.2-2%, described composite additive is that parachlormetaxylenol, Phenoxyethanol, Losec Thailand are fixed, one or more in glycerine. Composite alcohol sterilizing agent prepared by the present invention have have no side effect, noresidue, the feature such as pungency is little, alcohol class component concentration is low, bacterium, fungi, mould are had good killing effect.
Description
Technical field
The invention belongs to chemostefilant field, particularly relate to a kind of composite alcohol sterilizing agent and its preparation method.
Background technology
Alcohol class is conventional sterilizing agent composition, and what be wherein most widely used is ethanol. The mechanism of action of alcohol disinfectant is the metabolism of solidifying protein, interference microorganism, and anti-bacteria is bred, and causes microbial death, belongs to middle effect sterilizing agent. Bacterial propagule, virus, fungi there are is killing action, gram-positive microorganism comparison Gram-negative bacteria sterilization effect is slightly strong, bacterial spore is invalid. There is germicidal action fast, the feature of noresidue. Extensively for skin degerming, medical apparatus sterilizing and surface disinfection. Being used alone ethanol when sterilizing, optimum concn is 70-75%. The germicidal action of alcohol class strengthens along with the increase of molecular weight.
Summary of the invention
The present invention provides the compound method of a kind of composite alcohol sterilizing agent. Bacterium, fungi and mould are had good killing effect by this sterilizing agent.
Its concrete technical scheme is as follows:
A kind of composite alcohol sterilizing agent, it is characterised in that: sterilizing agent comprises the raw material of following mass percent concentration: ethanol: 20-30%, n-propyl alcohol: 30-40%, tensio-active agent 0.2-2%, composite additive 0.2-2%, and surplus is water; Described composite additive is that parachlormetaxylenol, Phenoxyethanol, Losec Thailand are fixed, one or more in glycerine.
Described tensio-active agent be anion surfactant, cats product, nonionogenic tenside one or more.
Described anion surfactant is one or more in fatty acid salt tensio-active agent or sulfonate surfactant.
Described cats product is quaternary ammonium salt surface active agent.
. described nonionogenic tenside is one or more in polyoxyethylene-type surfactant or amine oxide type tensio-active agent.
Described anion surfactant is sodium alkyl benzene sulfonate and/or Xylo-Mucine.
Described cats product is alkyl dimethyl benzyl ammonium chloride or Alkyl dimethyl benzyl ammonium bromide.
Described nonionogenic tenside is one or more in dodecyl oxyethyl group sultaine, octadecyl dihydroxy ethyl amine oxide, fatty alcohol-polyoxyethylene ether.
The present invention also provides the preparation method of above-mentioned composite alcohol sterilizing agent, step is as follows: concentration drops into ethanol and n-propyl alcohol in Agitation Tank by mass percentage, stir after evenly and add tensio-active agent again, stirring adds composite additive after making it dissolve, stir evenly, add the water of specified amount, continue to be stirred to and mix, namely obtain composite alcohol sterilizing agent finished product.
The temperature of described process for preparation is no more than 30 DEG C.
Composite alcohol sterilizing agent of the present invention has following technology feature and advantage:
1. existing 75% conventional ethanol disinfection agent main problem in use is that the killing effect to mould is not ideal enough. Major antibacterial composition of the present invention is made up of ethanol and n-propyl alcohol, and total alcohol content is less than 70%, has the advantage that pungency is little, alcohol class component concentration is low. Bacterium, fungi and mould there is good killing effect. Compared with single component ethanol disinfection agent, the killing effect of mould is significantly increased. With reference to the testing method requirement of 2002 editions Ministry of Health's " sterilizing agent technical specifications ", " carrier spraying quantitative sterilization " evaluation method is adopted to evaluate, 75% ethanol effect 1 minute, black-koji mould density loss 3.5 logarithmic value can be made, and sterilizing agent effect of the present invention 1 minute, black-koji mould density loss can be made to be greater than 5.0 logarithmic value.
2. the present invention uses tensio-active agent to improve sterilizing agent to the wettability of body surface, promotes the contact action of sterilizing agent and body surface.
3. the present invention uses composite additive to improve physical properties and the sterilizing activity of composite alcohol sterilizing agent. Parachlormetaxylenol is that a kind of toxicity is extremely low and be widely used in the antimildew and antibacterial agent of household chemicals field, is soluble in ethanol, and to gram-negative, positive bacteria, fungi, mould has killing action. Can be used for improving composite alcohol sterilizing agent to the action effect of fungi and mould. Phenoxyethanol is a kind of novel alcohols material with certain antibacterial effect, is applied to makeup and medicine corrosion-resistant field, can be miscible with ethanol, and Pseudomonas aeruginosa especially has stronger killing action. Losec Thailand is a kind of biocide surely, and gram-negative, positive bacteria and fungi are had broad-spectrum antibacterial action. Can be used for improving composite alcohol sterilizing agent to the action effect of fungi. Glycerine has volatility, can be used as wetting agent and the contact of thickening material improvement composite alcohol sterilizing agent and body surface, and performance is retained in contact when especially composite alcohol sterilizing agent acts on vertical surface.
Composite alcohol sterilizing agent of the present invention have have no side effect, noresidue, the feature such as pungency is little, alcohol class component concentration is low. Bacterium, fungi, mould there is good killing effect.
Embodiment
Embodiment 1
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 30kg and n-propyl alcohol 30kg, stir evenly; 2) in Agitation Tank, octadecyl dihydroxy ethyl amine oxide 2kg is dropped into, stirring and dissolving;3) in Agitation Tank, drop into Phenoxyethanol 200g, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 2
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 20kg and n-propyl alcohol 40kg, stir evenly; 2) in Agitation Tank, dodecyl dimethyl benzyl ammonium bromide 200g, stirring and dissolving is dropped into; 3) in Agitation Tank, drop into parachlormetaxylenol 500g, glycerine 1.5kg successively, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 3
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 25kg and n-propyl alcohol 35kg, stir evenly; 2) in Agitation Tank, Sodium dodecylbenzene sulfonate 500g, stirring and dissolving is dropped into; 3) in Agitation Tank, drop into Losec Thailand determine 500g, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 4
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 25kg and n-propyl alcohol 35kg, stir evenly; 2) in Agitation Tank, octadecyl dihydroxy ethyl amine oxide 1kg and ethoxylated dodecyl alcohol 1kg is dropped into, stirring and dissolving; 3) in Agitation Tank, drop into parachlormetaxylenol 200g, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 5
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 25kg and n-propyl alcohol 35kg, stir evenly; 2) in Agitation Tank, Xylo-Mucine 500g and Sodium dodecylbenzene sulfonate 500g, stirring and dissolving is dropped into; 3) in Agitation Tank, drop into glycerine 1.5kg, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 6
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 30kg and n-propyl alcohol 30kg, stir evenly; 2) in Agitation Tank, stearyl dimethyl benzyl ammonium chloride 1kg, stirring and dissolving is dropped into; 3) in Agitation Tank, drop into parachlormetaxylenol 500g, Phenoxyethanol 500g, glycerine 1kg, stir evenly; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 7
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 20kg and n-propyl alcohol 40kg, stir evenly; 2) in Agitation Tank, octadecyl dimethyl benzyl brometo de amonio 1kg, stirring and dissolving is dropped into; 3) in Agitation Tank, drop into parachlormetaxylenol 500g, Phenoxyethanol 500g, Losec Thailand determine 500g, glycerine 500g, stir even; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 8
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 30kg and n-propyl alcohol 30kg, stir evenly; 2) in Agitation Tank, dodecyl oxyethyl group sultaine 500g is dropped into, stirring and dissolving; 3) in Agitation Tank, drop into parachlormetaxylenol 500g, Phenoxyethanol 500g, Losec Thailand determine 500g, glycerine 500g, stir even;4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
Embodiment 9
Prepare according to the following steps: 1) in Agitation Tank, drop into ethanol 25kg and n-propyl alcohol 35kg, stir evenly; 2) in Agitation Tank, octadecyl dihydroxy ethyl amine oxide 500g and octadecyl dimethyl benzyl brometo de amonio 500g is dropped into, stirring and dissolving; 3) in Agitation Tank, drop into parachlormetaxylenol 500g, Phenoxyethanol 500g, Losec Thailand determine 500g, glycerine 500g, stir even; 4) add water to 100L, continue stirring and within 30 minutes, namely obtain composite alcohol sterilizing agent finished product.
Process for preparation control temperature of reaction system is no more than 30 DEG C.
[test data of experiment]
Composite alcohol sterilizing agent of the present invention, with reference to the testing method requirement of 2002 editions Ministry of Health's " sterilizing agent technical specifications ", " carrier spraying quantitative sterilization " evaluation method is adopted to be evaluated by the sterilization effect of formula, this test request sterilizing agent regulation working concentration and under action time, for test bacterial classification killing rate higher than 3 logarithmic value. Our experiments show that bacterium, fungi and mould are had good killing action. Refer to following table 1 to table 2.
Table 1 sterilizing agent effect of the present invention 1 minute killing effect to bacterium
Table 2 sterilizing agent effect of the present invention 1 minute is to the killing effect of fungi and mould
Claims (10)
1. a composite alcohol sterilizing agent, it is characterised in that: being made up of the raw material of following mass percent concentration in described sterilizing agent: ethanol 20-30%, n-propyl alcohol 30-40%, tensio-active agent 0.2-2%, composite additive 0.2-2%, surplus is water; Described composite additive be parachlormetaxylenol, Phenoxyethanol, Losec Thailand fixed in one or more.
2. composite alcohol sterilizing agent as claimed in claim 1, it is characterised in that: described tensio-active agent be anion surfactant, cats product, nonionogenic tenside one or more.
3. composite alcohol sterilizing agent as claimed in claim 2, it is characterised in that: described anion surfactant is fatty acid salt tensio-active agent and/or sulfonate surfactant.
4. composite alcohol sterilizing agent as claimed in claim 2, it is characterised in that: described cats product is quaternary ammonium salt surface active agent.
5. composite alcohol sterilizing agent as claimed in claim 2, it is characterised in that:. described nonionogenic tenside is polyoxyethylene-type surfactant and/or amine oxide type tensio-active agent.
6. composite alcohol sterilizing agent as claimed in claim 3, it is characterised in that: described anion surfactant is sodium alkyl benzene sulfonate and/or Xylo-Mucine.
7. composite alcohol sterilizing agent as claimed in claim 4, it is characterised in that: described cats product is alkyl dimethyl benzyl ammonium chloride or Alkyl dimethyl benzyl ammonium bromide.
8. composite alcohol sterilizing agent as claimed in claim 5, it is characterised in that: described nonionogenic tenside is one or more in dodecyl oxyethyl group sultaine, octadecyl dihydroxy ethyl amine oxide, fatty alcohol-polyoxyethylene ether.
9. prepare the method for the arbitrary described composite alcohol sterilizing agent of claim 1-8 for one kind, it is characterized in that: step is as follows: concentration drops into ethanol and n-propyl alcohol in Agitation Tank by mass percentage, stir after evenly and add tensio-active agent again, stirring adds composite additive after making it dissolve, stir evenly, add the water of specified amount, continue to be stirred to and mix, namely obtain composite alcohol sterilizing agent finished product.
10. prepare the method for composite alcohol sterilizing agent as claimed in claim 9, it is characterised in that: the temperature of described process for preparation is no more than 30 DEG C.
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| CN104082293B true CN104082293B (en) | 2016-06-08 |
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| CN106305775A (en) * | 2016-08-22 | 2017-01-11 | 怀远县渔业科技发展有限责任公司 | Pond bottom disinfectant for loach pond and preparation method thereof |
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| CN1736198A (en) * | 1998-01-20 | 2006-02-22 | 伊西康公司 | Deep penetrating anti-microbial compositions |
| WO2008057773A2 (en) * | 2006-10-27 | 2008-05-15 | 3M Innovative Properties Company | Antimicrobial compositions |
| CN103889220A (en) * | 2011-10-07 | 2014-06-25 | 美国消毒器公司 | A non-aerosol foaming alcohol hand sanitizer |
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2014
- 2014-07-17 CN CN201410340248.2A patent/CN104082293B/en active Active
Patent Citations (6)
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| CN1079504A (en) * | 1992-06-04 | 1993-12-15 | 邢志铿 | Waterless detergent for cleaning hand and manufacture method thereof and purposes |
| CN1256709A (en) * | 1997-05-20 | 2000-06-14 | 新药研究(澳大利亚)有限公司 | Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism |
| CN1736198A (en) * | 1998-01-20 | 2006-02-22 | 伊西康公司 | Deep penetrating anti-microbial compositions |
| CN1613440A (en) * | 2003-11-07 | 2005-05-11 | 曾繁铁 | Non-poaching hand protective cleaning juice |
| WO2008057773A2 (en) * | 2006-10-27 | 2008-05-15 | 3M Innovative Properties Company | Antimicrobial compositions |
| CN103889220A (en) * | 2011-10-07 | 2014-06-25 | 美国消毒器公司 | A non-aerosol foaming alcohol hand sanitizer |
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