JP2007023009A - Antimicrobial cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To develop a protamine-containing cosmetic having an antimicrobial effect over a long period, especially a detergent or soap for washing the bodies. <P>SOLUTION: This detergent/soap little deteriorating the antimicrobial property with the passage of time is characterized by containing protamine not in a free form but in a salt. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a cosmetic having antibacterial properties, and more particularly to a body cleaning detergent having antibacterial properties.

Antibacterial agents, antiseptics, and the like are often added to detergents and soaps in order to prevent deterioration of quality due to microorganisms and to provide antibacterial, sterilizing, sterilizing, disinfecting, deodorant and other effects. It is well known that phenols, quaternary ammonium salts, acids and the like are used.
In recent years, attention has been paid to the safety of chemicals, but it is often difficult in practice to achieve both the intended effect and safety.

  Researches are going on to use safe antibacterial components derived from safe organisms without using synthetic drugs, and there are also moves to use polyphenols and the like. One proposal is to use protamine in cosmetics (Patent Document 1). Although a certain effect is recognized, there is a problem from the viewpoint of long-term stability.

  JP 2001-89317 A

  The inventors of the present invention have developed an object of the present invention to develop a protamine-containing cosmetic material that has a stable antibacterial effect over a long period of time, in particular, a detergent and soap for body cleaning.

  The present inventors have found that antibacterial properties can be maintained for a long period of time by containing protamine in the form of a salt rather than a free form of protamine, and solved the problems of the present invention.

  That is, the present invention is a cosmetic comprising a salt of protamine.

  Further, the present invention is a cosmetic in which the protamine salt is one or more selected from inorganic acid salts.

  Moreover, this invention is cosmetics whose salt of this protamine is 1 type (s) or 2 or more types chosen from the sulfate, hydrochloride, carbonate, or phosphate.

  Moreover, this invention is cosmetics whose salt of this protamine is 1 type, or 2 or more types chosen from the salt of organic acid.

  Moreover, this invention is cosmetics whose salt of this protamine is 1 type (s) or 2 or more types chosen from the salt of carboxylic acids.

  Furthermore, the present invention is a cosmetic in which the salt of the carboxylic acid is a salt of a hydroxycarboxylic acid.

  Furthermore, the present invention provides a cosmetic in which the hydroxycarboxylic acid salt is one or more of carboxylic acid salts selected from malic acid, tartaric acid, citric acid, gluconic acid, glycolic acid, lactic acid, and glyceric acid. It is a fee.

  Moreover, this invention is cosmetics whose said cosmetics are cleaning cosmetics.

  Further, the present invention is a cosmetic in which the cleaning cosmetic is a body cleaning detergent.

  Moreover, this invention is cosmetics whose said detergent for body cleaning is solid soap.

  Moreover, this invention is cosmetics whose said detergent for body cleaning is a liquid detergent.

  Moreover, this invention is cosmetics whose pH for this said body cleaning detergent is 8 or more.

  Moreover, this invention is cosmetics whose detergent for body cleaning is a detergent used for body cleaning at the time of handling of foodstuffs, and engaging in medical treatment.

Embodiments of the invention will be described in detail below.
The present invention is a cosmetic comprising a salt of protamine. Among cosmetics, it is suitable for cosmetics that are cleaning cosmetics.

  In recent years, in order to reduce the irritation to the skin, the pH of the detergent / soap may be lowered. However, the basic cleanability of the detergent / soap is superior in alkaline. For this reason, an antibacterial agent effective in the alkaline region is desired.

  Protamine is known to be efficiently extracted from fish, especially salmon and salmon roe, and because of its antibacterial properties, it is also used as a safe food preservative of biological origin. Is excellent in alkalinity, and is therefore preferably blended into detergents and soaps with excellent detergency.

  However, free protamine (protamine not in salt form) has the disadvantage of lacking long-term stability. The inventors of the present invention have found that it is effective to add protamine to a detergent / soap in the form of a salt in order to improve this drawback. That is, as will be described in detail later in the examples, the detergent / soap to which free protamine is added has a lower antibacterial property after 1 year than the antibacterial property immediately after production, but added protamine in the form of salt. Detergents and soaps have almost no decline in antibacterial properties even after a year.

  The pH can be easily confirmed by, for example, measuring the pH of the 1% aqueous solution, and the pH is desirably 8 or more. Such detergents / soaps are suitably used as detergents / soaps used for body cleaning when handling food, engaging in medical care / nursing, and engaging in medical waste handling operations.

  The salts of protamines of the acids shown below can be prepared by reacting protamine with the acids of the following examples or the sodium salts, potassium salts and the like of those acids.

Examples of protamine salts include inorganic acid salts such as sulfate, hydrochloride, carbonate and phosphate, salts of monocarboxylic acids such as formic acid and acetic acid, oxalic acid, malonic acid, oxalic acid, glutaric acid, adipine Preferably used are salts of dicarboxylic acids such as acid, pimelic acid, suberic acid, azelaic acid and sebacic acid, and salts of hydroxycarboxylic acids such as malic acid, tartaric acid, citric acid, glycolic acid, lactic acid, glyceric acid and gluconic acid. It is done.
Among the inorganic acid salts, carbonates are more preferably used because of their ease of preparation.
Among organic acid salts, biologically derived hydroxycarboxylic acid salts are more suitable because they are safe. Among them, malic acid, tartaric acid, and citric acid are easily, inexpensively and stably available. Salts are most preferably used.

  If the amount of the protamine salt added is less than 0.0001 wt, the antibacterial effect of the protamine salt is not exhibited well. Even if a larger amount than 1 wt% is added, the antibacterial effect does not increase to the extent that the added amount increases. Accordingly, 0.0001 wt% to 10 wt% is preferably added and used, but 0.001 wt% to 1 wt% is more preferably used, and 0.01 wt% to 1 wt% is most preferably added and used.

  In the case of solid soap, the cosmetic of the present invention can be produced by adding a protamine salt to a soap base and kneading. As the soap base, known ones can be used, for example, animal oils such as beef tallow, pig oil, whale oil, fish oil, vegetable oils such as olive oil, palm oil, palm oil, peanut oil, etc. Depending on the condition, the dried and adjusted water content is used. In the case of a liquid detergent, it can be produced by adding a protamine salt to an aqueous surfactant solution or an aqueous emulsion, stirring and mixing.

  Moreover, the component generally added to cosmetics can be mix | blended with the cosmetics of this invention as needed. For example, a fragrance | flavor, an oil-based component, saccharides, alcohol, a moisturizer, a thickener, antioxidant, etc. can be mix | blended.

  Hereinafter, the present invention will be described based on examples. However, the present invention is not limited to these examples, and can be arbitrarily modified within the scope of the technical idea of the present invention.

Comparative Example 1

  A soap base made from palm oil was prepared. The soap base itself was used as Comparative Example Sample 1.

Comparative Example 2

  1 wt% free protamine was added to the soap base and kneaded to obtain Comparative Sample 2.

Comparative Example 3

  0.01 wt% free protamine was added to the soap base and kneaded to obtain Comparative Sample 3.

Comparative Example 4

  A 20% aqueous solution of polyoxyethylene lauryl ether sulfate surfactant was prepared as a stock solution for a liquid detergent. The solution itself was referred to as Comparative Example 4.

Comparative Example 5

  To the liquid detergent stock solution of Comparative Example 4, 0.01 wt% free protamine was added, stirred and mixed to obtain Comparative Sample 5.

  Example sample 1 was prepared by adding 0.01 wt% protamine-sulfate to the soap base and kneading.

  Example Sample 2 was prepared by adding and kneading 0.1 wt% of protamine-tartrate to the soap base.

  0.01 wt% of protamine-citrate was added to the soap base and kneaded to obtain Example Sample 3.

  Example Sample 4 was prepared by adding 0.01 wt% protamine-carbonate to the liquid detergent stock solution of Comparative Example Sample 1 and stirring and mixing.

  Prepare two samples each of the above comparative example samples 1-5 and example samples 1-4 in a polyethylene bag with a chuck, one in a -5 ° C refrigerator and the other in a 40 ° C incubator. Each was stored for 1 year and used as a test sample. A sample stored in a refrigerator at −5 ° C. was distinguished from the sample A, and a sample stored in a thermostat at 40 ° C. was identified as B. A sample stored in a refrigerator at −5 ° C. can be regarded as a sample that has not deteriorated with time.

Antibacterial test Soap A and B prepared in each comparative example and each example and stored over time were dissolved in boiled and cooled distilled water to prepare a 1% aqueous solution. A petri dish containing an agar medium was prepared according to a conventional method, and about 0.01 g of each solution was sprayed. Each petri dish was left outdoors for about 24 hours and then heated at 36 ± 2 ° C. for 5 days. It observed with the microscope of 400 times.

  In the petri dishes of Comparative Samples 1A, 1B, 3B, 4A, 4B, and 5B, significant bacterial growth was observed. In Comparative Examples Samples 2A, 3A, and 5A and Examples Samples 1, 2, 3, and 4 of A and B Petri dishes, significant bacterial growth could not be confirmed. Although it was not remarkable in the petri dish of the comparative example sample 2B, the growth of the bacteria was clearly observed.

The invention's effect

  As described above, the present invention can provide a detergent / soap for body cleaning that is derived from a natural product, has high safety, and does not denature over a long period of time and can maintain an antibacterial effect.

Claims (13)

  A cosmetic comprising a salt of protamine.   The cosmetic according to claim 1, wherein the salt of protamine is one or more selected from salts of inorganic acids.   The cosmetic according to claim 2, wherein the salt of the inorganic acid is one or more selected from sulfate, hydrochloride, carbonate or phosphate.   The cosmetic according to claim 1, wherein the salt of protamine is one or more selected from salts of organic acids.   The cosmetic according to claim 4, wherein the salt of the organic acid is one or more selected from salts of carboxylic acids.   The cosmetic according to claim 5, wherein the salt of the carboxylic acid is a salt of a hydroxycarboxylic acid.   The makeup of claim 6, wherein the hydroxycarboxylic acid salt is one or more of carboxylic acid salts selected from malic acid, tartaric acid, citric acid, gluconic acid, glycolic acid, lactic acid, and glyceric acid. Fee.   The cosmetic according to any one of claims 1 to 7, wherein the cosmetic is a cleaning cosmetic.   The cosmetic according to claim 8, wherein the cleaning cosmetic is a body cleaning detergent.   The cosmetic according to claim 9, wherein the detergent for body cleaning is a soap bar.   The cosmetic according to claim 9, wherein the body cleaning detergent is a liquid detergent.   The cosmetic according to any one of claims 8 to 10, wherein the detergent for body cleaning has a pH of 8 or more.   The cosmetic according to any one of claims 9 to 11, wherein the detergent for body cleaning is a detergent used for body cleaning when handling food or engaging in medical treatment.