JP5674344B2 - Skin disinfectant cleaner composition - Google Patents

Description

  The present invention relates to a skin sterilizing and cleaning composition that exhibits a high bactericidal effect even when used for a short time.

  In recent years, hand washing has been promoted in hospitals, nursing homes, food processing sites, kitchens, and the like for the purpose of preventing pathogenic bacteria from being transmitted and transmitted through fingers. In such a field, various skin sterilization detergent compositions are used in order to more reliably sterilize and clean the skin. For example, there are compositions containing a disinfectant in skin (finger) disinfectant and a composition containing a high disinfectant solvent such as ethanol.

  In Patent Document 1, a high bactericidal effect is obtained by the combined use of a specific anionic surfactant and triclosan, isopropylphenol and / or parachloroxylenol, and by containing glyceryl ether as a third component, foamability and low temperature stability are obtained. A liquid sterilizing detergent composition having excellent properties is proposed.

  Patent document 2 proposes to use a mixture containing glyceryl ether at a temperature of 25 ° C. or higher in order to sterilize the surface of the article.

JP 2008-138027 A JP 2004-315537 A

  In the above field, workers are often busy, and it is not practical to spend a long time washing hands.

  In order to reliably sterilize and clean the skin in a short time, for example, there is a method of increasing the content of various active ingredients. However, when the content of the active ingredient is increased, the stability of the composition particularly at low temperature storage tends to decrease. Since low-temperature storage is usually performed in the distribution process, if the stability of the composition is reduced, for example, when precipitation or separation of crystals occurs, the desired effect may not be exhibited during use.

  Therefore, the object of the present invention is to provide a sufficient degree of bactericidal properties even in a short time of use, taking into consideration the actual hand washing time in busy sites, and excellent stability during low temperature storage Another object is to provide a skin sterilizing and cleaning composition.

  Accordingly, as a result of studying various factors relating to the skin sterilizing detergent composition, the present inventors have deliberately changed the pH of the skin sterilizing detergent composition from a neutral range to an acidic range where the pH is 5.5 or less. Surprisingly, it has been found that sufficient bactericidal properties are exhibited in a shorter time, and furthermore, by blending polyhydric alcohol into the composition, the composition can be stored at low temperature without surprisingly reducing the bactericidal properties. The present inventors have found that the stability of time can be improved and completed the present invention.

That is, the gist of the present invention is as follows.
[1] Component (a): 0.05-2% by mass of at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol, (b) component: carbon number 4-12 Glyceryl ether having a hydrocarbon group and component (c): the following general formula (1)
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(In the formula, R represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average number of added moles, n = 0 to 3, M represents an ammonium ion, an alkali metal ion, an alkaline earth metal ion, Or an alkanol ammonium ion.) 0.5 to 35% by mass of an anionic surfactant represented by the following formula: (e) component: polyhydric alcohol (excluding component (b)) A skin sterilizing and cleaning composition containing 23% by mass, the pH at 25 ° C. being 5.5 or less; and [2] used for hand soap, body shampoo or hair shampoo, The composition according to [1] above.

  The skin sterilizing detergent composition of the present invention has an excellent effect of having a detergency effect and exhibiting a high bactericidal property even when used for a short time. Moreover, even when the composition is stored at a low temperature, it has an excellent effect that high stability is ensured. As a use form of the product of the present invention, it is possible to use the composition as a skin sterilization cleansing composition without diluting it, or to dilute it.

<(A) component>
The component (a) used in the present invention is at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol. 0.05-2 mass% is preferable and, as for content of (a) component in the skin disinfection cleaning composition of this invention, 0.3-1.2 mass% is more preferable. From the viewpoint of sufficiently exerting the bactericidal effect, the content is preferably 0.05% by mass or more, and from the viewpoint of ensuring the stability of the composition, the content is preferably 2% by mass or less.

  These fungicides are preferably used in combination of two from the viewpoint of bactericidal performance, and more preferably used in combination with triclosan and isopropylphenol from the viewpoint of raw material odor. In this case, triclosan / isopropylphenol = 5/1 to 1/3 (mass ratio) is preferable, 4/1 to 1/3 (mass ratio) is more preferable, and 3/1 to 1/2 (mass ratio) is further. preferable.

<(B) component>
The component (b) used in the present invention is a glyceryl ether having a hydrocarbon group having 4 to 12 carbon atoms, preferably a linear or branched alkyl group or alkenyl group, and a linear chain having 8 to 12 carbon atoms. Or the monoalkyl body which has a branched alkyl group is preferable.

  Examples of the alkyl group include n-octyl group, 2-ethylhexyl group, n-nonyl group, n-decyl group, isodecyl group, n-undecyl group, and n-dodecyl group, and preferably 8 carbon atoms. To 12 alkyl groups, specifically, 2-ethylhexyl group and isodecyl group.

  Specific examples of glyceryl ether include 2-ethylhexyl glyceryl ether and isodecyl glyceryl ether. (B) The glyceryl ether of a component may be used individually by 1 type, or may be used in combination of 2 or more type.

  By blending the component (b) into the skin sterilizing detergent composition, the effect of further exerting the sterilizing effect against bacteria such as Escherichia coli can be achieved without reducing the cleaning effect of the detergent composition against fat and oil stains. The

  0.2-23 mass% is preferable, as for content of (b) component in a skin disinfection cleaning composition, 1-21 mass% is more preferable, and 1.2-20 mass% is further more preferable. The content is preferably 0.2% by mass or more from the viewpoint of exerting a bactericidal effect on bacteria such as Escherichia coli without reducing the cleaning effect on fat and oil stains, and from the viewpoint of product stability, the content is 23% by mass. % Or less is preferable.

<(C) component>
The component (c) in the skin sterilizing and cleaning composition of the present invention has the following general formula (1):
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(In the formula, R is a hydrocarbon group having 8 to 16 carbon atoms, preferably a saturated or unsaturated aliphatic group having 8 to 16 carbon atoms, n represents an average added mole number, and n = 0 to 3; M is an ammonium ion, an alkali metal ion, an alkaline earth metal ion, or an alkanol ammonium ion). As carbon number of R, 10-16 are preferable. As the average added mole number n, 0 to 3 are used, and 0 to 1 is preferable from the viewpoint of sterilization performance. Further, the counter ion represented by M is an ammonium ion, an alkali metal ion, an alkaline earth metal ion, or an alkanol ammonium ion, and specifically, an ammonium ion, a sodium ion, a potassium ion, a lithium ion, or calcium. Ions, triethanolammonium ions, diethanolammonium ions, and monoethanolammonium ions. Ammonium ions are preferred from the viewpoint of sterilization performance.

  Specific examples of the component (c) include polyoxyethylene (0) alkyl ether sulfate triethanolamine (alkyl sulfate triethanolamine), polyoxyethylene (0) alkyl ether ammonium sulfate (alkyl ammonium sulfate), and polyoxyethylene (0). Sodium alkyl ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) alkyl ether triethanolamine sulfate, polyoxyethylene (1) ammonium alkyl ether sulfate, polyoxyethylene (2) ammonium alkyl ether sulfate, polyoxyethylene (2) alkyl Examples include sodium ether sulfate. From the viewpoints of foaming, bactericidal performance, and skin irritation, polyoxyethylene (1) alkyl ether sulfate triethanolamine and polyoxy Styrene (1) alkyl ether sulfate is preferable. In addition, in this specification, the numerical value in the parenthesis of these compounds means the average added mole number of ethylene oxide. As the component (c), one type of these compounds may be used alone, or a plurality of types may be used in combination.

  Content of (c) component in the skin disinfection cleaning composition of this invention is 0.5-35 mass%, 3-32 mass% is preferable, and 15-30 mass% is more preferable. The content is preferably 0.5% by mass or more from the viewpoint of sufficiently exhibiting foamability and detergency, and is preferably 15% by mass or more from the viewpoint of transport efficiency of the composition. The content is preferably 35% by mass or less from the viewpoint of sufficiently exerting and the low temperature storage stability of the composition of the present invention.

  The mass ratio of the component (c) to the component (b) is preferably (c) / (b) = 0.9 / 1 to 15/1, more preferably 1/1 to 12/1, and 1/1. More preferred is 10 to 10/1. From the viewpoint of ensuring product stability during low-temperature storage without reducing the cleaning effect on fat and oil stains, the mass ratio is preferably 0.9 / 1 or more, from the viewpoint of exerting a bactericidal effect against bacteria such as E. coli, The mass ratio is preferably 15/1 or less.

  The mass ratio of the component (c) and the component (a) is preferably (c) / (a) = 100/10 to 1000/5, and 100/10 to 100/2 from the viewpoint of sufficiently exerting the bactericidal effect. More preferred.

<(E) component>
The product of the present invention contains a polyhydric alcohol excluding component (b) as component (e). That is, in the present specification, the compound corresponding to the component (b) among the compounds generally treated as polyhydric alcohols is not the component (e) but the component (b). The polyhydric alcohol preferably has 2 to 6 carbon atoms, and preferably 2 to 6 carbon atoms. Specifically, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, sorbitol and the like are preferable, and dipropylene glycol and 1,3-butylene glycol are more preferable. (E) As a polyhydric alcohol of a component, you may use individually by 1 type or may be used in combination of 2 or more type. (E) As content of a component, it is 0.05-23 mass%, 0.1-20 mass% is preferable, and 0.5-15 mass% is more preferable. 0.05% by mass or more from the viewpoint of improving the stability of the product during low-temperature storage without reducing the bactericidal properties, and increasing the concentration of the components (a), (b), (c) and (d) described later From the viewpoint of low-temperature storage stability, it is preferably 23% by mass or less.

<Skin disinfectant cleaning composition>
The skin sterilizing and cleaning composition of the present invention is preferably in a liquid state using water as a medium. The amount of water can be appropriately set according to the amount of each component.

  The pH of the skin disinfectant cleaning composition (25 ° C.) of the present invention is 5.5 or less. pH can be calculated | required by measuring the undiluted | stock solution (25 degreeC) of the skin disinfection cleaning composition of this invention. Many conventional skin sterilizing and cleaning compositions have a neutral pH range (for example, 6 to 8) from the viewpoint of suppressing irritation to the skin. By reducing to 5 or less, the further improvement of the disinfection performance of a composition is aimed at. By making the skin sterilization detergent composition acidic, adverse effects on the skin (irritation, hand feeling, etc.) may occur, but since the skin sterilization detergent composition of the present invention is excellent in sterilization performance, By using the composition of the present invention for a short time, sufficient sterilization performance can be exhibited, and as a result, such adverse effects can be greatly relieved.

  The pH of the skin sterilizing and cleaning composition (25 ° C.) of the present invention is preferably 3.0 to 5.5, and preferably 3.5 to 5.2 from the viewpoint of achieving both improved bactericidal properties and low skin irritation. Is more preferable, and 4.0 to 5.0 is more preferable. From the viewpoint of bactericidal properties, 5.5 or less is preferable, 5.2 or less is more preferable, and 5.0 or less is more preferable. From the viewpoint of irritation, 3.0 or more is preferable, 3.5 or more is more preferable, and 4.0 or more is more preferable.

  Although the details of the mechanism of ensuring high bactericidal properties even when used for a short time by setting the pH of the skin sterilizing and cleaning composition (25 ° C.) of the present invention to 5.5 or less are not clear, When the fungicide component is adsorbed to the cell surface by the glyceryl ether in the system and acts, it is assumed that the pH has some influence on the penetration of the fungicide into the cell.

  Examples of the pH adjuster used for adjusting the pH of the skin sterilizing and cleaning composition of the present invention to a desired range include pH adjusters known in the technical field of the present invention, but citric acid, malic acid, Hydroxy acids such as tartaric acid are preferred.

<(D) component>
In the present invention, the component (d) preferably further contains at least one compound selected from the group consisting of benzoate, sorbate, propionate, salicylate and dehydroacetate. It is more preferable to contain an acid salt. (D) As content of a component, 0.01-2.5 mass% of the skin disinfection cleaning composition of this invention is preferable, 0.05-1.75 mass% is more preferable, 0.1-1 More preferred is mass%. From the viewpoint of sufficiently exhibiting the bactericidal effect, the content is preferably 0.01% by mass or more, and from the viewpoint of ensuring the stability of the composition, the content is preferably 2.5% by mass or less. As the salt, alkali metal salts such as sodium salt and potassium salt are preferable. As the compound of component (d), one type may be used alone, or two or more types may be used in combination.

  (D) Although the mechanism about the point which the disinfection performance of the skin disinfection cleaning composition of this invention improves further by including a component is not clear, (D), so that pH of the composition of this invention becomes lower. It is considered that the proportion of non-dissociable molecules in the component increases, and when the pH of the composition of the present invention (25 ° C.) becomes 5.5 or less, this non-dissociable molecule is converted into component (a), It is estimated that it contributes to the sterilization performance by the component (b) and / or the component (c).

  Furthermore, the skin sterilizing detergent composition of the present invention is a component used in ordinary skin sterilizing detergent compositions, for example, lower alcohols such as ethanol; plant-derived polysaccharides such as guar gum; microorganism-derived polysaccharides such as xanthan gum. Celluloses such as hydroxypropylcellulose and carboxymethylcellulose; coloring agents such as dyes and pigments; inorganic salts such as sodium chloride and sodium sulfate; plant extracts; preservatives; chelating agents such as EDTA; vitamins; Anti-inflammatory agents such as dipotassium; antioxidants such as BHT; humectants such as ceramide analogs such as natural ceramide and synthetic ceramide, etc. may be contained within a range not impairing the effects of the present invention.

  The skin sterilizing and cleaning composition of the present invention can be used by filling it into a container that is usually used. However, by filling it into a former container, it has good foaming properties and good foam stability. Therefore, it is more preferable to fill the former container. The above shows the conditions when using the stock solution. In the case of dilution use, it is more preferable to fill the former container with the diluent.

  The skin sterilizing and cleaning composition of the present invention can be produced according to a conventional method. For example, after the component (a) is dissolved in the component (b), the component (c), water, the component (d) and the component (e) are added, and the skin sterilization detergent composition (25 ° C.) with a pH adjuster. Can be produced so as to have a pH of 5.5 or less. As for the blending amount of each component, the description of the content of each component described above can be applied as it is as the description of the blending amount.

  Furthermore, the skin sterilization cleaning composition of the present invention is preferably used as a liquid sterilization cleaning agent for the body, for example, a hand cleaning agent such as a hand soap, a body shampoo, and a hair shampoo. It is more preferable to be used as a cleaning agent, and as an application site, it is further preferable to be used for a hospital, a nursing facility, or a kitchen.

Hereinafter, an example is given and it demonstrates in detail. In addition, content of each component in a following example etc. was shown by the mass% in Table 1 and Table 2 on the basis of the effective part. In addition, about the numerical value of the component ratio (c component / b component, c component / a component) in a table | surface, the denominator (/ 1) was abbreviate | omitted and described. In addition, this invention product 12 in Table 1 is a reference example.

(C) component in each table | surface is as follows.
1: Ammonium lauryl sulfate 2: Triethanolamine lauryl sulfate 3: Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆ ) ether ammonium sulfate 4: Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆ ) ether triethanolamine sulfate 5: Polyoxyethylene (2) alkyl (C ₁₀ -C ₁₆ ) ether ammonium sulfate 6: Polyoxyethylene (2) alkyl (C ₁₀ -C ₁₆ ) sodium ether sulfate

(Test method and evaluation criteria for bactericidal effect)
As test bacteria, Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used. A culture solution pre-cultured in an SCD medium [manufactured by Nippon Pharmaceutical Co., Ltd.] was prepared in advance. Culture 0.1mL of ^{(10 9 ~10 10 cell / mL} ), a predetermined concentration with sterile water (compositions dilution × 3, × 10, × 40 ) in a dilute solution of the composition of 2mL diluted in Vaccinated. Every fixed time (15 seconds, 30 seconds), one platinum loop was taken from each diluted solution and inoculated into 1 mL of a growth medium (SCDLP medium [manufactured by Nippon Pharmaceutical Co., Ltd.]). After the growth liquid medium was cultured at 37 ° C. for 24 hours, the presence or absence of growth of the bacteria was observed.

  The presence or absence of fungal growth was determined visually. That is, when turbidity was observed in the cultured medium, it was determined that the bacteria had grown. Since one type of skin sterilizing detergent composition was tested for sterilizing effect at three dilution concentrations and two contact times, visual judgment was performed on a total of six growth media. The determination of the bactericidal effect was performed as follows according to the number of growth media in which the growth of bacteria was not observed. When no growth of bacteria was observed (that is, no growth of bacteria was observed for all 6 growth media), the highest score (full score) was 6, and the total dilution concentration and total reaction time were The case where the growth of bacteria was observed in all of the growth media was set to 0 as the lowest score. That is, it means that the higher the value between 0 and 6, the higher the bactericidal effect of the skin sterilizing detergent composition. About a result, the test was done 3 times about one sample and the average value of the obtained value was shown as sterilization performance.

(Cleaning effect test method and evaluation criteria)
Samples 1 and 2 below were used as a model for oily and dirt stains.
0.5 mL of the oil / fat sample of Sample 1 was taken and applied uniformly to the palm. Hands were washed with 1 mL of each composition (washing and rinsing for 15 seconds each, water temperature of about 30 ° C., tap water, constant amount of water). Subsequently, Sample 2 was also evaluated in the same manner.

Sample 1: Squalane (deep sea bream liver extract oil), reagent, [manufactured by Tokyo Chemical Industry Co., Ltd.]
Sample 2: Cottonseed oil, reagent, [manufactured by Kanto Chemical Co., Ltd.]

  The cleaning effect was evaluated by five panelists. The panelists were instructed to perform the hand washing operation in the same manner for all the compositions, and did not inform which of the compositions was the product of the present invention and which was a comparative product. The case where fat and oil stains were completely removed was set to 5, and the case where no oily stains were removed was set to 1, and the cleaning effect was sensory evaluated with an integer between 1 and 5. It means that the higher the value, the higher the cleaning effect of the composition against oil stains. The numerical value was determined by the average value of Sample 1 and Sample 2.

(Stability test methods and evaluation criteria for low temperature storage of products)
The composition described in Tables 1 and 2 was placed in a colorless and transparent glass container (capacity 100 mL), stored at 5 ° C. for 60 days, stored immediately after production, stored for 30 days, stored for 60 days, and the appearance when compared was as follows: The evaluation was based on the criteria.

3: Even after reaching the 60th day, no crystal precipitation was observed, and no solidification occurred. Separation is not allowed.
2: From the 31st day to the 60th day, any of crystal precipitation, solidification and separation is observed.
1:30 By the 30th day, any of crystal precipitation, solidification and separation is observed.

Example 1 and Comparative Example 1
Compositions having the compositions shown in Tables 1 and 2 were prepared according to a conventional method, and a bactericidal effect test, a cleaning effect test, and a stability test during low-temperature storage were performed. Tables 1 and 2 show the results of the bactericidal effect and stability test at low temperature storage. The cleaning effect of the product of the present invention and the comparative product is in the range of 4 to 5 except that the evaluation value of the comparative product 4 is 2, indicating that these compositions exhibit an excellent cleaning effect.

  Thus, it was found that the product of the present invention effectively killed Escherichia coli and Staphylococcus aureus by contact for an extremely short time (for example, within 15 seconds) assuming actual hand washing.

  On the other hand, if a comparative product is examined, when it does not contain any of (a) component, (b) component, (c) component and (e) component, or when any of them is less than a predetermined content, the bactericidal effect is The results were not sufficient (Comparative products 1 and 2), or the stability during storage at low temperature was insufficient (Comparative products 3, 5 and 6). Even when the content of the component (c) or the component (e) exceeded a predetermined amount, the stability during low-temperature storage was not sufficient (Comparative products 4 and 7). Even when the pH exceeded the predetermined range, the bactericidal effect was not sufficient (Comparative Product 8).

  Furthermore, when the products 2, 7 and 8 of the present invention are compared with the comparative products 5 to 7, when the content of the component (e) satisfies a predetermined range, the bactericidal effect and the stability at low temperature storage are sufficient effects. Is obtained (invention products 2, 7 and 8), when the component (e) is not blended (comparative product 5), when the content of the component (e) is too small (comparative product 6) and (e) In any case where the component content was excessive (Comparative Product 7), the stability during low-temperature storage was not sufficient. From this, it was demonstrated that the stability of the composition during low-temperature storage can be improved without reducing the bactericidal effect by blending a predetermined amount of the component (e).

Example 2 (hand soap)
A hand soap having the following composition was produced by a conventional method. The pH of the obtained hand soap solution (25 ° C.) was 5.0 (25 ° C.), and was excellent in detergency and high in bactericidal effect. In addition, five panelists replied that they did not experience irritation or touch when they cleaned their fingers for normal use over two weeks.

Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆₎ ether sulfate: 5.0 (wt%)
2-ethylhexyl glyceryl ether: 2.0 (mass%)
・ Triclosan: 0.3 (mass%)
・ Isopropylmethylphenol: 0.1 (mass%)
Propylene glycol: 5.0 (mass%)
・ Sodium benzoate: 0.3 (mass%)
-PH adjuster (citric acid): appropriate amount (amount that makes hand soap pH 5.0)
・ Purified water: Balance ・ Total: 100 (mass%)

  The skin sterilizing and cleaning composition of the present invention has a high sterilizing effect in a short use time without increasing the amount of the sterilizing agent, and is therefore suitable for use in hospitals, nursing homes, food processing sites, kitchens and other sites. Applicable to.

Claims (5)

(A) Component: 0.05-2% by mass of at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol, (b) component: hydrocarbon group having 4-12 carbon atoms And glyceryl ether having the following formula (1)
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(In the formula, R represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average number of added moles, n = 0 to 3, M represents an ammonium ion, an alkali metal ion, an alkaline earth metal ion, Or an alkanolammonium ion.) 0.5 to 35% by mass of an anionic surfactant represented by the following formula: (e) component: propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin and sorbitol by weight of at least one polyhydric alcohol skin disinfection detergent composition containing from 0.05 to 23 wt% selected from the group consisting of state, and are pH 5.5 or less at 25 ° C., (c) mass ratio of the component and the component (b) (c) / (b) = Ru 0.9 / 1 to 10/1 der, skin bactericidal detergent composition. The composition according to claim 1, wherein the mass ratio of the component (c) to the component (a) is (c) / (a) = 100/10 to 100/2. The composition of Claim 1 or 2 whose pH of this composition (25 degreeC) is 3.0-5.5. The component (d): at least one compound selected from the group consisting of benzoate, sorbate, propionate, salicylate and dehydroacetate is further contained in any one of claims 1 to 3. The composition as described. The composition according to any one of claims 1 to 4 , which is used for hand soap, body shampoo or hair shampoo.