JP7175134B2 - skin cleanser composition - Google Patents

Description

The present invention relates to skin cleanser compositions.

BACKGROUND ART In recent years, in hospitals, nursing homes, food processing sites, kitchens, etc., hand washing has been promoted for the purpose of preventing transmission of pathogenic bacteria through fingers. In such fields, various skin sterilizing cleansing compositions are used in order to perform sterilizing cleansing of the skin more reliably.
The present applicant has also proposed a skin disinfecting cleanser composition containing, for example, a specific anionic surfactant, a disinfectant and glyceryl ether (see Patent Documents 1 and 2).
On the other hand, we have proposed a liquid detergent composition for cleaning hard surfaces with excellent detergency by combining alkyl glucoside, a nonionic surfactant that is gentle on the hands, as the main cleansing base and glyceryl ether (patent Reference 3).

JP 2010-168555 A JP 2011-256301 A Japanese Patent Application Laid-Open No. 2008-106128

However, although the skin antiseptic cleanser compositions described in Patent Documents 1 and 2 had an excellent antiseptic effect, they produced relatively coarse foam and had problems with their detergency, and the actual use of the user It was difficult to feel that cleaning and sterilization had been thoroughly performed.
Therefore, in order to improve detergency, an alkyl glucoside described in Patent Document 3 was used in combination.

Therefore, as a result of various studies, the present inventors have found that, together with a specific anionic surfactant, a fungicide, and an alkyl glucoside, a saturated monohydric alcohol having 1 to 3 carbon atoms in a small amount than the bactericidal effect is expressed. , Glyceryl ether and glyceryl ether at a specific ratio, it is found that the detergency is improved while exhibiting a high bactericidal effect. It has been found that a skin cleansing composition can be obtained that spreads even to small parts such as joints, fingertips and between nails, is easily absorbed, and has an excellent feeling of cleansing.

The present invention provides the following components (A), (B), (C), (D) and (E):
(A) general formula (1)
R1 ^- O-( _CH2CH2O ) _{n - SO3M} (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents the average number of added moles, n = 0 to 3, M represents an alkali metal, alkaline earth metal, ammonium or showing alkanolammonium)
1.0 to 10% by mass of an anionic surfactant represented by
(B) 0.5 to 5.0% by mass of glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass,
(D) alkyl glucoside 0.5 to 7% by mass,
(E) saturated monohydric alcohol having 1 to 3 carbon atoms 0.5 to 15 mass%
and wherein the mass ratio (B)/(E) of component (B) to component (E) is 0.10-5.

INDUSTRIAL APPLICABILITY The skin cleanser composition of the present invention is excellent in detergency and fineness of foam while exhibiting an excellent bactericidal effect. Especially during use, the foam quality is fine, and the fine bubbles spread to small areas such as wrinkles on the hands, joints, fingertips and between the nails, so that they can be easily absorbed and thoroughly washed and sterilized by the user. The user can feel that the cleaning is being performed.

The component (A) anionic surfactant used in the present invention is represented by the general formula (1).
In the formula, the hydrocarbon group represented by R ¹ is preferably a saturated or unsaturated aliphatic hydrocarbon group having 8 to 16 carbon atoms, and an alkyl groups are more preferred. The average number of added moles n is from 0 to 3, preferably from 0 to 1 from the viewpoint of improving the sterilization performance. Examples of M include sodium, potassium, lithium, calcium, ammonium, triethanolammonium, diethanolammonium and monoethanolammonium. Ammonium is preferred from the viewpoint of bactericidal performance.

Examples of component (A) include polyoxyethylene (0) alkyl ether sulfate triethanolamine (alkyl sulfate triethanolamine), polyoxyethylene (0) alkyl ether sulfate ammonium (alkyl sulfate ammonium), polyoxyethylene (0) alkyl Sodium ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) alkyl ether sulfate triethanolamine, polyoxyethylene (1) alkyl ether sulfate ammonium, polyoxyethylene (2) alkyl ether sulfate ammonium, polyoxyethylene (2) alkyl ether sodium sulfate and the like. Among these, polyoxyethylene (1) alkyl ether sulfate triethanolamine and polyoxyethylene (1) alkyl ether sulfate ammonium are preferred from the viewpoints of foaming, sterilization performance, and skin irritation.
In the present specification, the numerical values in parentheses for these compounds mean the average number of added moles of ethylene oxide.

Component (A) can be used alone or in combination of two or more, and the content must be 1.0% by mass or more in the entire composition from the viewpoint of achieving both sterilization and fineness of foam. is preferably 1.3% by mass or more, more preferably 1.6% by mass or more, further preferably 2.0% by mass or more, must be 10% by mass or less, preferably 8.0% by mass or less, 5.0% by mass or less is more preferable, and 4.0% by mass or less is even more preferable. In addition, the content of component (A) is required to be 1.0 to 10% by mass in the entire composition, preferably 1.3 to 8.0% by mass, and 1.6 to 5.0% by mass. % is more preferred, and 2.0 to 4.0% by mass is even more preferred.

Component (B) is a glyceryl ether having a hydrocarbon group of 4-22 carbon atoms. From the viewpoint of improving storage stability and sterilization properties, glyceryl ethers having a linear or branched alkyl group or alkenyl group having 6 to 18 carbon atoms are preferred, and linear or branched alkyl groups having 8 to 12 carbon atoms. A monoalkyl derivative having a group is more preferred.

Linear or branched alkyl groups having 8 to 22 carbon atoms include, for example, n-octyl group, 2-ethylhexyl group, n-nonyl group, n-decyl group, isodecyl group, n-undecyl group and n-dodecyl. groups. Among these, branched alkyl groups having 8 to 12 carbon atoms are preferred, and branched alkyl groups having 8 to 10 carbon atoms are more preferred, from the viewpoint of achieving both detergency and sterilization properties. Specifically, a 2-ethylhexyl group, An isodecyl group is mentioned.

Specific examples of component (B) include those containing one or more selected from glycerin mono-2-ethylhexyl ether, glycerin monoisodecyl ether and glycerin monoisostearyl ether. From the viewpoint of achieving both bactericidal properties, it preferably contains one or two selected from glycerin mono-2-ethylhexyl ether and glycerin monoisodecyl ether, and glycerin mono-2-ethylhexyl ether and/or glycerin monoisodecyl. More preferably, it contains an ether.
As component (B), commercially available products of glycerin mono-2-ethylhexyl ether (Penetol GE-EH, manufactured by Kao Corporation) and glycerin monoisodecyl ether (Penetol GE-ID, manufactured by Kao Corporation) are preferably used. be able to.

Component (B) can be used alone or in combination of two or more, and the content should be 0.5% by mass or more in the entire composition from the viewpoint of improving storage stability and bactericidal properties. is preferably 0.8% by mass or more, more preferably 1.0% by mass or more, still more preferably 1.5% by mass or more, 5.0% by mass or less is required, and 4.0% by mass or less is It is preferably 3.0% by mass or less, more preferably 2.5% by mass or less. The content of component (B) must be 0.5 to 5.0% by mass, preferably 0.8 to 4.0% by mass, and 1.0 to 3.0% by mass. 0% by mass is more preferable, and 1.5 to 2.5% by mass is even more preferable.

The component (C) fungicide is at least one selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol.
The content of component (C) must be 0.01% by mass or more in the entire composition, preferably 0.02% by mass or more, and 0.05% by mass, from the viewpoint of compatibility between storage stability and bactericidal properties. The above is more preferable, 0.8 mass % or less is required, 0.5 mass % or less is preferable, and 0.3 mass % or less is more preferable. In addition, the content of component (C) must be 0.01 to 0.8% by mass, preferably 0.02 to 0.5% by mass, more preferably 0.05 to 0.05% by mass in the total composition. 3% by mass is more preferred.

Alkylglucosides of component (D) include alkylglucosides represented by the following general formula (2).
_R2- ( _OR3)mGp ^{( 2} )
(In the formula, R ² represents a linear alkyl group having 8 to 16 carbon atoms, R ³ represents an alkylene group having 2 to 4 carbon atoms, G represents a group derived from a reducing sugar, and m represents the average addition mole represents a number, represents a number from 0 to 5, p is the average degree of condensation and represents a number from 1 to 3)

In the alkylglucoside of general formula (2), the starting reducing sugar may be either an aldose or a ketose, and may include triose, tetrose, pentose and hexose having 3 to 6 carbon atoms. Specifically, aldoses include apiose, arabinose, galactose, glucose, lyxose, mannose, galose, aldose, idose, talose and xylose, and ketoses include fructose. Among these, aldopentose or aldohexose having 5 or 6 carbon atoms are preferred, and glucose is more preferred.

Examples of alkylglucosides of component (D) include octylpolyglucoside, 2-ethylhexylpolyglucoside, decylpolyglucoside, laurylpolyglucoside, myristylpolyglucoside, palmitylpolyglucoside, isostearylpolyglucoside, stearyllaurylpolyglucoside, oleyl. and polyglucosides.

Component (D) can be used alone or in combination of two or more, and the content should be 0.5% by mass or more in the entire composition from the viewpoint of achieving both sterilization and fineness of foam. is preferably 0.8% by mass or more, more preferably 1.5% by mass or more, still more preferably 2.5% by mass or more, and must be 7.0% by mass or less, and 6.0% by mass % or less, more preferably 5.0 mass % or less, and even more preferably 4.5 mass % or less. In addition, the content of component (D) must be 0.5 to 7.0% by mass in the total composition, preferably 0.8 to 6.0% by mass, and 1.5% by mass. ~5.0% by mass is more preferable, and 2.5 to 4.5% by mass is even more preferable.

In the present invention, the mass ratio (B)/(D) of component (B) to component (D) is preferably 0.30 or more, more preferably 0.35 or more, from the viewpoint of achieving both sterilization and detergency. , is more preferably 0.40 or more, preferably 6 or less, more preferably 4 or less, and even more preferably 2 or less. The mass ratio of component (B) to component (D) is preferably 0.30 to 6, more preferably 0.35 to 4, even more preferably 0.40 to 2.

Examples of component (E) saturated monohydric alcohols having 1 to 3 carbon atoms include methanol, ethanol, propanol, isopropanol, etc. From the viewpoint of both detergency and sterilization properties, ethyl alcohol and/or isopropanol are preferred. , more preferably ethanol.
These components are used as sterilizing/disinfecting alcohols, and their sterilizing effect can be obtained by containing them in high concentrations. For example, in the case of ethanol, a practical bactericidal effect (killing bacteria within 5 minutes) can be obtained at a concentration of 40 to 80% by mass in the composition. In addition, at a low concentration of 15% by mass or less, the growth of bacteria is inhibited or the bactericidal effect is very weak, and no practical bactericidal effect can be expected. However, in the present invention, along with a specific anionic surfactant, glyceryl ether, fungicide, alkyl glucoside, a very small amount of saturated monohydric alcohol having 1 to 3 carbon atoms than the bactericidal effect is expressed, glyceryl ether and specific By containing it in a certain ratio, it is possible to obtain a skin cleanser composition exhibiting a high bactericidal effect and having excellent detergency and foam quality.

The content of component (E) must be 0.5% by mass or more in the entire composition, preferably 0.8% by mass or more, and 1.0% by mass or more, from the viewpoint of achieving both detergency and sterilization properties. is more preferably 2.0% by mass or more, 15% by mass or less is necessary, 10% by mass or less is preferable, 7.0% by mass or less is more preferable, and 4.0% by mass or less is even more preferable. In addition, the content of component (E) must be 0.5 to 15% by mass in the total composition, preferably 0.8 to 10% by mass, and 1.0 to 7.0% by mass. More preferably, 2.0 to 7.0% by mass, even more preferably 2.0 to 4.0% by mass.

In the present invention, the mass ratio (B)/(E) of component (B) to component (E) is 0.10 or more from the viewpoint of achieving both sterilization and detergency and improving storage stability, 0.15 or more is preferable, 0.5 or more is more preferable, it is 5 or less, 2 or less is preferable, and 1.5 or less is further preferable. The mass ratio (B)/(E) of component (B) to component (E) is 0.10 to 5, preferably 0.15 to 2, more preferably 0.5 to 1.5.

In the present invention, the mass ratio (A)/(E) of component (A) to component (E) is preferably 0.05 or more, more preferably 0.1 or more, from the viewpoint of improving detergency and foaming. It is preferably 0.3 or more, more preferably 5 or less, more preferably 3 or less, and even more preferably 1.5 or less. Further, the mass ratio (A)/(E) of component (A) to component (E) is preferably 0.05 to 5, more preferably 0.1 to 3, and even more preferably 0.3 to 1.5. .

Further, in the present invention, the mass ratio (E)/(D) of component (E) to component (D) is preferably 0.05 or more from the viewpoint of improving foaming and detergency and maintaining sterilization properties. 0.1 or more is more preferable, 0.5 or more is more preferable, 5 or less is preferable, 3 or less is more preferable, and 1.5 or less is even more preferable. Further, the mass ratio (E)/(D) of component (E) to component (D) is preferably 0.05 to 5, more preferably 0.1 to 3, and even more preferably 0.5 to 1.5. .

The skin cleanser composition of the present invention contains (F) water as a solvent.
The content of water in component (F) can be appropriately set according to the amount of each component. Preferably, 65 to 90% by mass, and even more preferably 70 to 85% by mass.

The skin cleanser composition of the present invention may further contain (G) a polyol from the viewpoint of fine foam quality and good rinsability.
Examples of such polyols include dihydric alcohols such as ethylene glycol, diethylene glycol, hexylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol and 1,3-butylene glycol; trihydric or higher alcohols such as glycerin, tetraglycerin, hexaglycerin, decaglycerin, trimethylpropanol; Sugars or sugar alcohols such as sorbitan and sorbitol are included.
Among these, one or more selected from propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, 1,3-butylene glycol and sorbitol from the viewpoint of improving low-temperature stability and enhancing moist feeling after washing. is preferred, more preferably one or more selected from propylene glycol, polypropylene glycol, glycerin and 1,3-butylene glycol, more preferably one or more selected from propylene glycol, polypropylene glycol and glycerin, Moreover, it is preferable to contain at least glycerin.

The polyol of component (G) can be used alone or in combination of two or more, and the content is 1% by mass or more in the entire composition from the viewpoint of improving foam quality and improving rinsability. It is preferably 3% by mass or more, more preferably 5% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 9% by mass or less. The content of component (G) is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, and even more preferably 5 to 9% by mass in the total composition.

The skin cleanser composition of the present invention may further contain (H) polyoxyethylene alkyl ether carboxylic acid or a salt thereof from the viewpoint of improving skin cleansing properties while maintaining bactericidal properties.
Examples of polyoxyethylene alkyl ether carboxylic acids or salts thereof of component (H) include those represented by general formula (3).

^R4 -O-( _CH2CH2O ) _q - _{CH2 -} COOX (3)
(In the formula, R ⁴ represents an alkyl group having 4 to 22 carbon atoms, q represents a number of 0 to 20, and X represents a hydrogen atom, alkali metal, alkaline earth metal, ammonium or organic ammonium.)

In the formula, R ⁴ is an alkyl group having 4 to 22 carbon atoms, more preferably an alkyl group having 6 to 20 carbon atoms, still more preferably 8 to 8 carbon atoms, from the viewpoint of improving washability and low-temperature stability. It is an alkyl group of 18 carbon atoms, more preferably an alkyl group of 10 to 16 carbon atoms. The alkyl chain of R ⁴ may be either linear or branched, but a linear alkyl group is preferred from the viewpoint of foamability. In addition, the average carbon number of R ⁴ is preferably 10.8 to 12.8, more preferably 10.8 to 12, from the viewpoint of improving foamability and foam quality and improving low temperature stability. .5, more preferably 12.1 to 12.4.

In the formula, q represents a number of 0-20, more preferably 0-12. Incidentally, q indicates the number of added moles of ethylene oxide, and the average number of added moles of ethylene oxide in the composition of component (H) (the average value of q) improves the foamability and foam quality, From the viewpoint of improving stability, 1.5 to 10 is preferable, 2.5 to 6.4 is more preferable, 2.5 to 3.7 is more preferable, 2.5 to 3.4 is more preferable, 2 .8 to 3.4 are more preferred, and 2.8 to 3.1 are even more preferred.
WO2012/029950 can be referred to for the measurement of the alkyl composition of the alkyl ether carboxylic acid, the addition molar distribution of ethylene oxide, and the ratio of each component.

In the formula, X is a hydrogen atom; alkali metals such as sodium and potassium; alkaline earth metals such as calcium and magnesium; ammonium; mentioned. Among these, alkali metals are preferred, and sodium and/or potassium are more preferred, from the viewpoints of improving foamability and low-temperature stability and preventing coloration over time.

Specific examples of such polyoxyethylene alkyl ether carboxylic acid or salt thereof include polyoxyethylene lauryl ether carboxylic acid or salt thereof, polyoxyethylene myristyl ether carboxylic acid or salt thereof, and polyoxyethylene palmityl ether carboxylic acid. An acid or its salt etc. are mentioned. Among these, one or two selected from polyoxyethylene lauryl ether carboxylic acid or its salt and polyoxyethylene myristyl ether carboxylic acid or its salt from the viewpoint of improving foamability and foam quality is preferred, and it is more preferred to contain polyoxyethylene lauryl ether carboxylic acid or a salt thereof.
Examples of these commercially available products include Kao Akipo RLM-45 (manufactured by Kao Corporation), Kao Akipo RLM 45CA (manufactured by Kao Corporation), and Kao Akipo LM 26C (manufactured by Kao Corporation).

The content of component (H) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, more preferably 0.2% by mass in the entire composition from the viewpoint of improving foamability and foam quality. The above is more preferable, 2.0% by mass or less is preferable, 1.0% by mass or less is more preferable, and 0.7% by mass or less is even more preferable. The content of component (H) is preferably 0.05 to 2.0% by mass, more preferably 0.1 to 1.0% by mass, and even more preferably 0.2 to 0.7% by mass in the total composition. .

The skin cleanser composition of the present invention may further contain (I) cellulose to which a hydroxyethyl group or a hydroxypropyl group is added, from the viewpoint of improving foam quality and foam durability.
The cellulose of component (I) is one in which some of the hydrogen atoms in the hydroxyl groups of cellulose are substituted with hydroxyethyl groups or hydroxypropyl groups, and may have substituents other than these.

Specific examples include hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose and the like.
These are obtained by reacting cellulose with caustic soda to form alkali cellulose, then reacting with methyl chloride, monochloroacetic acid, ethylene oxide, propylene oxide, etc. to replace the hydrogen atoms in the hydroxyl groups of cellulose.

The cellulose of component (I) has an average degree of substitution of greater than 0, preferably 0.5 or more, preferably 3 or less, and more preferably 2 or less, from the viewpoint of the effect of improving foam persistence. In addition, the average molecular weight is preferably 200,000 or more, more preferably 500,000 or more, more preferably 650,000 or more, from the viewpoint of solubility in the skin cleanser composition and foam persistence effect. 000,000 or less is preferable, 2,000,000 or less is more preferable, and 1,600,000 or less is even more preferable.
In the present invention, the average degree of substitution is determined by NMR, and the average molecular weight is determined by using a gel permeation chromatography (GPC)-multi-angle laser light scattering detector (MALLS) system using polyethylene oxide as a standard substance. measured.

Component (I) is preferably hydroxyethyl cellulose, hydroxypropyl cellulose or hydroxypropylmethyl cellulose, preferably having an average degree of substitution of 0.5 to 2 and an average molecular weight of 650,000 to 1,600,000.

Further, as component (I), for example, for hydroxyethyl cellulose, CELLOSIZE QP52000H (manufactured by Dow Chemical Co.), HEC Daicel SE400, SE500, SE600, SE850, SE900 (manufactured by Daicel Finechem), etc.; , HPC-H, HPC-M (manufactured by Nippon Soda Co., Ltd.), etc; Commercially available products such as K35M, K100M and K200M (manufactured by ASHLAND) can be used.

Component (I) can be used alone or in combination of two or more, and the content thereof is preferably 0.1% by mass or more in the total composition from the viewpoint of fine foam quality and good foam sustainability. , more preferably 0.5% by mass or more, more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less. The content of component (I) is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass, and even more preferably 1 to 2% by mass in the total composition.

The skin cleanser composition of the present invention may further contain components other than components (A), (B), (D) and (H), which are used in ordinary cleansers, as long as the effects of the present invention are not impaired. Surfactants, moisturizers, oily ingredients, anti-inflammatory agents, preservatives, chelating agents, thickeners, salts, pearlizing agents, scrubbing agents, fragrances, cooling agents, pigments, UV absorbers, antioxidants, A plant extract or the like can be contained.

However, the content of the oily component in the skin cleanser composition is preferably 0 to 3% by mass, more preferably 0 to 2% by mass, and 0 to 1%, from the viewpoint of improving detergency and foamability. % by weight is more preferred, and 0 to 0.5% by weight is even more preferred. Here, the oily component is a hydrophobic substance that phase-separates from water, and includes oils and fats, hydrocarbon oils, ester oils, higher alcohols, silicone oils, and the like.
The content of surfactants other than components (A), (B), (D) and (H) is preferably 5% by mass or less in the skin cleanser composition from the viewpoint of maintaining bactericidal properties. , 3% by mass or less is more preferable, 1% by mass or less is more preferable, and 0.5% by mass or less is even more preferable.

The skin cleanser composition of the present invention is produced by mixing ingredients by a conventional method. The skin cleanser composition of the present invention can be prepared, for example, by heating component (F) water to 50 to 90° C., preferably 60 to 80° C., sequentially mixing each component, stirring and dissolving, and heating to 40° C. or less. , preferably by cooling to a temperature range of 20-30°C.
Preferably, from the viewpoint of improving the solubility of the component (C), it is preferable to mix the component (C) with the component (B) in advance and dissolve them sufficiently.
Preferably, from the viewpoint of suppressing volatilization of component (E), it is preferable to add and mix component (E) in a temperature range of 10 to 40° C. to a preparation in which components other than component (E) are mixed.
Preferably, the method for producing the skin cleanser composition of the present invention includes the following steps 1, 2 and 3.
Step 1: Add component (C) to component (B) and mix to dissolve.
Step 2: Heat the water of component (F) to 60-80°C and mix component (A), component (D), the preparation of step 1, and optionally component (G), component (H) and component (I). ) is added.
Step 3: Cool the preparation of step 2, add component (E) when cooled to 40°C and mix.
More preferably, step 4 includes a step of adjusting the pH to 3.0 to 6.0.

The skin cleanser composition of the present invention preferably has a pH of 3.0 to 6.0, more preferably 3.5 to 5.5, from the viewpoint of improving bactericidal activity and suppressing skin irritation. is more preferred, and 4.0 to 5.0 is even more preferred.
The pH of each skin cleanser composition was measured at 25° C. with a pH meter (manufactured by Horiba Ltd.: desktop pH/water quality analyzer LAQUA F-72T). For the measurement, a 5% aqueous solution was prepared using ion-exchanged water, and the pH of the solution was measured. At this time, the measurement is performed while gently stirring for 15 minutes until the value stabilizes, and the stable value after stirring is measured.

The skin cleansing composition of the present invention can be preferably used as a skin cleansing composition filled in containers such as pump foamers, pump dispensers, tubes, jars and squeeze dispensers.
When used by filling in a container other than a former container, the viscosity at 30 ° C. is preferably 1000 mPa s or more, preferably 2000 mPa s, from the viewpoint of suppressing dripping from the hand and improving the ease of spreading the formulation. 2500 mPa·s or more is more preferable, 9000 mPa·s or less is preferable, 7000 mPa·s or less is more preferable, and 5000 mPa·s or less is even more preferable. When used by filling in a container other than a foamer container, the specific viscosity (30°C) of the skin cleanser composition of the present invention is preferably 1000 to 9000 mPa·s, more preferably 2000 to 7000 mPa·s, and more preferably 2500 to 2500 mPa·s. 5000 mPa·s is more preferable.

The viscosity was measured by filling about 100 g of the skin cleanser composition into a container (standardized bottle (with cap and packing) No. 11 without air bubbles) and leaving it in a water bath set at 30°C for about 1 hour. After adjusting the temperature, the viscosity shall be measured for 1 minute using a Brookfield viscometer/VISCOMETER TVB-10M (manufactured by TOKI SANGYO CO., LTD) under the conditions of (i). However, if the measured value is within the accuracy range and a stable measured value is obtained, the measured value is accepted as the measured value. If not, measure under condition (ii) Repeat this operation to obtain a stable measurement value.
(i) No. M3: 12rpm,
(ii) No. M3: 30rpm,
(iii) No. M3: 6rpm,
(iv) No. M4: 12rpm,
(v) No. M4: 30rpm,
(vi) No. M4: 6rpm,
(vii) No. M2: 12rpm,
(viii) No. M2: 30rpm,
(viii) No. M2: 60rpm,
(x) No. M1: 30rpm,
(xi) No. M1: 60rpm,
(xii) No. M2: 100rpm

When the skin cleanser composition of the present invention is used by filling it in a foam container, the viscosity at 30° C. is preferably 150 mPa·s or less from the viewpoint of improving foam stability and foam fineness. , 100 mPa·s or less is more preferable, 50 mPa·s or less is more preferable, 1 mPa·s or more is preferable, 2 mPa·s or more is more preferable, and 3 mPa·s or more is still more preferable. When used in a foam container, the specific viscosity (30° C.) of the skin cleanser composition of the present invention is preferably 1 to 150 mPa·s, more preferably 2 to 100 mPa·s, and 3 to 50 mPa. • s is more preferred.

The skin cleansing composition of the present invention can be suitably used as a bactericidal skin cleansing composition because of its excellent bactericidal properties. As a specific dosage form, for example, face wash, body soap, hand soap, etc. are suitable, and hand soap is more preferred.

The present invention provides the following components (A), (B), (C), (D) and (E):
(A) general formula (1)
R1 ^- O-( _CH2CH2O ) _{n - SO3M} (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents the average number of added moles, n = 0 to 3, M represents an alkali metal, alkaline earth metal, ammonium or showing alkanolammonium)
1.0 to 10% by mass of an anionic surfactant represented by
(B) 0.5 to 5.0% by mass of glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass,
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) saturated monohydric alcohol having 1 to 3 carbon atoms 0.5 to 15 mass%
and the mass ratio (B)/(E) of component (B) to component (E) is 0.10 to 5. Gram-positive bacteria and / or Gram-negative bacteria are contacted with the composition A method for killing bacteria and/or Gram-negative bacteria may be provided.

Gram-positive and/or Gram-negative bacteria include, for example, Bacillus, Staphylococcus, Streptococcus, Lactobacillus, Clostridium, Listeria, Micrococcus, Propionibacterium. Gram-positive bacteria such as Bacterium; Escherichia, Pseudomonas, Enterobacter, Klebsiella, Citrobacter, Proteus, Serratia, Erwinia ( Erwinia), Vibrio, Acinetobacter and other Gram-negative bacteria. In particular, an excellent bactericidal effect can be exhibited against one or two species selected from bacteria belonging to Streptococcus aureus and Escherichia coli.
In addition, the sterilization in the present invention means that the bactericidal activity value is 4 or more in the bactericidal activity test in the examples. The contact time of the composition of the present invention with the Gram-positive bacteria and / or Gram-negative bacteria is 10 to 180 seconds, preferably 10 to 60 seconds, more preferably 20 to 180 seconds, from the viewpoint of sufficiently expressing bactericidal properties. It can be 40 seconds.

In relation to the above-described embodiments, the present invention further discloses the following compositions.
<1> The following components (A), (B), (C), (D) and (E):
(A) general formula (1)
R1 ^- O-( _CH2CH2O ) _{n - SO3M} (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents the average number of added moles, n = 0 to 3, M represents an alkali metal, alkaline earth metal, ammonium or showing alkanolammonium)
1.0 to 10% by mass of an anionic surfactant represented by
(B) 0.5 to 5.0% by mass of glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass,
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) saturated monohydric alcohol having 1 to 3 carbon atoms 0.5 to 15 mass%
and wherein the mass ratio (B)/(E) of component (B) to component (E) is 0.10-5.

<2> Component (A) is preferably polyoxyethylene (0) alkyl ether sulfate triethanolamine (alkyl sulfate triethanolamine), polyoxyethylene (0) alkyl ether sulfate ammonium (alkyl sulfate ammonium), polyoxyethylene ( 0) sodium alkyl ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) triethanolamine alkyl ether sulfate, polyoxyethylene (1) ammonium alkyl ether sulfate, polyoxyethylene (2) ammonium alkyl ether sulfate, polyoxyethylene (2) ) The skin cleanser composition according to <1> above, which is sodium alkyl ether sulfate, and more preferably polyoxyethylene (1) alkyl ether sulfate triethanolamine and polyoxyethylene (1) alkyl ether sulfate ammonium.
<3> The content of component (A) is preferably 1.3% by mass or more in the total composition, more preferably 1.6% by mass or more, and further preferably 2.0% by mass or more. 0% by mass or less, more preferably 5.0% by mass or less, and even more preferably 4.0% by mass or less, the skin cleanser composition according to <1> or <2>.

<4> Component (B) preferably contains one or more selected from glycerin mono-2-ethylhexyl ether, glycerin monoisodecyl ether and glycerin monoisostearyl ether, and glycerin mono- More preferably contains one or two selected from 2-ethylhexyl ether and glycerin monoisodecyl ether, and more preferably contains glycerin mono-2-ethylhexyl ether and glycerin monoisodecyl ether <1> to The skin cleanser composition according to any one of <3>.
<5> The content of component (B) is preferably 0.8% by mass or more in the total composition, more preferably 1.0% by mass or more, further preferably 1.5% by mass or more. 0% by mass or less, more preferably 3.0% by mass or less, and more preferably 2.5% by mass or less, the skin cleanser composition according to any one of <1> to <4>.
<6> The content of component (C) is preferably 0.02% by mass or more in the total composition, more preferably 0.05% by mass or more, preferably 0.5% by mass or less, and 0.5% by mass or less. The skin cleanser composition according to any one of <1> to <5>, which is more preferably 3% by mass or less.

<7> The alkyl glucoside of component (D) preferably has the general formula (2):
_R2- ( _OR3)mGp ^{( 2} )
(In the formula, R ² represents a linear alkyl group having 8 to 16 carbon atoms, R ³ represents an alkylene group having 2 to 4 carbon atoms, G represents a group derived from a reducing sugar, and m represents the average addition mole represents a number, represents a number from 0 to 5, p is the average degree of condensation and represents a number from 1 to 3)
An alkyl glucoside represented by
Octyl polyglucoside, 2-ethylhexyl polyglucoside, decyl polyglucoside, lauryl polyglucoside, myristyl polyglucoside, palmityl polyglucoside, isostearyl polyglucoside, stearyl lauryl polyglucoside, and oleyl polyglucoside are more preferred above <1> to <6. The skin cleanser composition according to any one of >.

<8> The content of component (D) is preferably 0.8% by mass or more in the total composition, more preferably 1.5% by mass or more, further preferably 2.5% by mass or more. 0% by mass or less, more preferably 5.0% by mass or less, and even more preferably 4.5% by mass or less, the skin cleanser composition according to any one of <1> to <7>.
<9> The mass ratio (B)/(D) of component (B) to component (D) is preferably 0.30 or more, more preferably 0.35 or more, and even more preferably 0.40 or more. , preferably 6 or less, more preferably 4 or less, and even more preferably 2 or less, according to any one of <1> to <8>.

<10> Component (E) is preferably methanol, ethanol, propanol or isopropanol, more preferably ethyl alcohol and/or isopropanol, and more preferably containing ethanol any of the above <1> to <9> 1. The skin cleanser composition according to claim 1.
The content of <11> (E) is preferably 0.8% by mass or more in the total composition, more preferably 1.0% by mass or more, further preferably 2.0% by mass or more, and 10% by mass % or less, more preferably 7.0 mass % or less, and even more preferably 4.0 mass % or less, according to any one of <1> to <10>.

<12> The mass ratio (B)/(E) of component (B) to component (E) is preferably 0.15 or more, more preferably 0.5 or more, and preferably 2 or less. The skin cleanser composition according to any one of <1> to <11>, which is more preferably 5 or less.
<13> The mass ratio (A)/(E) of component (A) to component (E) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.3 or more. , preferably 5 or less, more preferably 3 or less, and further preferably 1.5 or less, the skin cleanser composition according to any one of <1> to <12>.
<14> The mass ratio (E)/(D) of component (E) to component (D) is preferably 0.05 or more, more preferably 0.1 or more, further preferably 0.5 or more, The skin cleanser composition according to any one of <1> to <13>, which is preferably 5 or less, more preferably 3 or less, and further preferably 1.5 or less.
<15> The content of water in component (F) is preferably 60 to 95% by mass, more preferably 65 to 90% by mass, and even more preferably 70 to 85% by mass in the entire composition <1 > to the skin cleanser composition according to any one of <14>.

<16> The skin cleanser composition according to any one of <1> to <15>, further comprising (G) a polyol.
be able to.
<17> Component (G) is preferably one or more selected from propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, 1,3-butylene glycol and sorbitol, and propylene glycol and polypropylene glycol. , glycerin and 1,3-butylene glycol are more preferable, and one or more selected from propylene glycol, polypropylene glycol and glycerin are more preferable, and at least glycerin is preferably contained. The skin cleansing composition according to <16>.
<18> The content of component (G) is preferably 1% by mass or more in the total composition, more preferably 3% by mass or more, further preferably 5% by mass or more, and preferably 20% by mass or less, The skin cleanser composition according to <16> or <17>, which is more preferably 15% by mass or less, further preferably 9% by mass or less.

<19> The skin cleanser composition according to any one of <1> to <18>, further comprising (H) a polyoxyethylene alkyl ether carboxylic acid or a salt thereof.
<20> Component (H) polyoxyethylene alkyl ether carboxylic acid or a salt thereof preferably has the general formula (3):
^R4 -O-( _CH2CH2O ) _q - _{CH2 -} COOX (3)
(In the formula, R ⁴ represents an alkyl group having 4 to 22 carbon atoms, q represents a number of 0 to 20, and X represents a hydrogen atom, alkali metal, alkaline earth metal, ammonium or organic ammonium.)
is represented by
More preferably, polyoxyethylene lauryl ether carboxylic acid or its salt, polyoxyethylene myristyl ether carboxylic acid or its salt, polyoxyethylene palmityl ether carboxylic acid or its salt, polyoxyethylene lauryl ether carboxylic acid or its salt, and poly The skin cleanser according to <19> above preferably contains one or two selected from oxyethylene myristyl ether carboxylic acid or a salt thereof, and more preferably contains polyoxyethylene lauryl ether carboxylic acid or a salt thereof. agent composition.
<21> The content of component (H) is preferably 0.05% by mass or more in the entire composition, more preferably 0.1% by mass or more, further preferably 0.2% by mass or more, and 2 The skin cleanser composition according to <19> or <20> above, which is preferably 0% by mass or less, more preferably 1.0% by mass or less, and further preferably 0.7% by mass or less.

<22> The skin cleanser composition according to any one of <1> to <21>, further comprising (I) a cellulose to which a hydroxyethyl group or a hydroxypropyl group is added.
<23> Component (I) is preferably hydroxyethylcellulose, hydroxypropylcellulose, or hydroxypropylmethylcellulose, having an average degree of substitution of 0.5 to 2 and an average molecular weight of 650,000 to 1,600,000. The skin cleanser composition according to <22> above, wherein is more preferred.
<24> The content of component (I) is preferably 0.1% by mass or more in the total composition, more preferably 0.5% by mass or more, further preferably 1% by mass or more, and 5% by mass. The following is preferable, 3 mass % or less is more preferable, and 2 mass % or less is still more preferable. <22> or <23>.

<25> The content of the oily component in the skin cleanser composition is preferably 0 to 3% by mass, more preferably 0 to 2% by mass, even more preferably 0 to 1% by mass, and 0 to 0% by mass. .The skin cleanser composition according to any one of <1> to <24>, which is more preferably 5% by mass.
<26> The content of surfactants other than components (A), (B), (D) and (H) is preferably 5% by mass or less and 3% by mass in the skin cleanser composition. The skin cleanser composition according to any one of <1> to <25> above is more preferable, more preferably 1% by mass or less, and even more preferably 0.5% by mass or less.
<27> At 25° C., the pH is preferably 3.0 to 6.0, more preferably 3.5 to 5.5, and even more preferably 4.0 to 5.0 above <1> to <26> The skin cleanser composition according to any one of

<28> The skin cleanser composition according to any one of <1> to <27>, which is preferably used by being filled in a container such as a pump foamer, pump dispenser, tube, jar, squeeze dispenser, or the like.
<29> When used by filling in a container other than a former container, the viscosity at 30°C is preferably 1000 mPa s or more, more preferably 2000 mPa s or more, still more preferably 2500 mPa s or more, and 9000 mPa s or less. is preferable, 7000 mPa·s or less is more preferable, and 5000 mPa·s or less is even more preferable.
<30> When used by being filled in a former container, the viscosity at 30°C is preferably 150 mPa s or less, more preferably 100 mPa s or less, even more preferably 50 mPa s or less, and 1 mPa s. The skin cleanser composition according to <28> above is preferably 2 mPa·s or more, more preferably 3 mPa·s or more.

<31> The skin cleanser composition according to any one of the above <1> to <30>, which is preferably a sterilizing skin cleanser composition.
<32> Preferably, the method for producing a skin cleanser according to any one of <1> to <26>, including the following steps 1, 2 and 3.
Step 1: Add component (C) to component (B) and mix to dissolve.
Step 2: Heat the water of component (F) to 60-80°C and mix component (A), component (D), the preparation of step 1, and optionally component (G), component (H) and component (I). ) is added.
Step 3: Cool the preparation of step 2, add component (E) when cooled to 40°C and mix.
More preferably, step 4 includes a step of adjusting the pH to 3.0 to 6.0.

Examples 1-11, Comparative Examples 1-6
Skin cleansing compositions having the compositions shown in Tables 1 and 2 were produced, and their detergency, bactericidal properties and foam quality were evaluated. The results are also shown in Tables 1 and 2.

(Production method)
Step 1: Component 3 (component (C)) is added to component 2 (component (B)) and mixed to dissolve.
Step 2: Heat Component 12 (Component (F)) to 70° C. and convert Component 1 (Component (A)), the preparation of Step 1, Components 4 and 5 (Component (D)), Component 7 (Component (G )), Component 8 (Component (H)), Components 9, 11 and 13 are added, and Component 10 is added with mixing until the pH is 4.5.
Step 3: Cool the preparation of Step 2 and add Component 6 (Component (E)) when it drops to 30°C and mix to obtain a skin cleanser composition.

(Evaluation method)
(1) Detergency:
20 μL of carbon black-colored lard stain was applied to a BIOSKIN plate (manufactured by Beaulux) in the range of φ30 mm, and allowed to stand in a constant temperature chamber at 35° C. for 20 minutes. The color difference ΔE before washing was measured with a spectrophotometer (CM-600d, manufactured by Konica Minolta), using the measured value of the bioskin plate before stain application as an initial value. Then 1 mL of each composition was massaged for 30 seconds and rinsed with 25° C. tap water (4 L/min) for 15 seconds. After sufficiently drying, the color difference ΔE after washing was measured, and the washing rate was calculated from the following formula. The average value of cleaning rates at three locations was classified according to the following criteria.
Washing rate [%]=[1-(ΔE after washing)/(ΔE before washing)]*100
A: 60% or more.
B: 50% or more and less than 60%.
C: Less than 50%.

(2) Bactericidal:
Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used as test bacteria. As an inactivating solution, 38 g (powder) of SCDLP medium "Daigo" (manufactured by Wako Pure Chemical Industries, Ltd.), 30 g of LP diluent ("Daigo" manufactured by Wako Pure Chemical Industries, Ltd.), and deionized water were added to make 1000 mL, and LP was increased. of SCDLP medium was prepared. A culture solution pre-cultured in SCD medium (manufactured by Wako Pure Chemical Industries, Ltd.) was prepared in advance. 0.03 mL of culture (3.3-9.9×10 ⁸ CFU/mL) was inoculated into 3 mL of each composition. After a period of time (30 seconds), 0.1 mL of the solution was inoculated into 0.9 mL of inactivation solution. As a control, the same test was conducted using sterilized ion-exchanged water instead of each composition. A dilution series was prepared with sterilized ion-exchanged water and plated on SCDLP agar medium (Becton Dickinson). After incubation at 37°C for 24 hours, the number of grown colonies was counted, and the bactericidal activity value was calculated from the following formula. The average value when the same experiment was conducted three times was classified according to the following criteria.
Bactericidal activity value = LOG ((number of remaining bacteria when inoculating composition) / (number of remaining bacteria when inoculating sterile ion-exchanged water))
A: 4.5 or more.
B: 4 or more and less than 4.5.
C: less than 4.

(3) Foam quality:
The foam quality (fineness) was evaluated by three panelists. The panelists were instructed to perform the same hand washing procedure for all compositions, and details of each composition were not disclosed. A sensory evaluation was made on the fineness of the foam between 1 and 5. A value of 5 indicates cream-like fine foam, and a value of 1 indicates no foam, and the higher the value, the finer the foam. The average score of 3 people was calculated and classified according to the following criteria.
A: Average score of 4 or more.
B: Average score of 3 or more and less than 4.
C: Average score less than 3.

Formulation Examples 1-29
A disinfecting skin cleanser composition having the composition shown in Table 3-5 was produced in the same manner as in Examples.
All of the obtained skin cleansing compositions were excellent in detergency, sterilization and foam quality.

Claims (5)

The following components (A), (B), (C), (D) , (E) and (H):
(A) general formula (1)
R1 ^- O-( _CH2CH2O ) _{n - SO3M} (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents the average number of added moles, n = 0 to 3, M represents an alkali metal, alkaline earth metal, ammonium or showing alkanolammonium)
1.0 to 10% by mass of an anionic surfactant represented by
(B) 0.5 to 5.0% by mass of glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass,
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) 0.5 to 15% by mass of a saturated monohydric alcohol having 1 to 3 carbon atoms ,
(H) polyoxyethylene alkyl ether carboxylic acid or salt thereof
and wherein the mass ratio (B)/(E) of component (B) to component (E) is 0.10-5. 2. The skin cleanser composition according to claim 1, wherein the mass ratio (B)/(D) of component (B) to component (D) is 0.30-2. 3. The skin cleanser composition according to claim 1, further comprising (G) a polyol. The skin cleanser composition according to any one of claims 1 to 3 , wherein the mass ratio (A)/(E) of component (A) to component (E) is 0.05-5. 5. The skin cleanser composition according to any one of claims 1 to 4 , further comprising (I) cellulose to which a hydroxyethyl group or a hydroxypropyl group is added.