JP2023049566A - Liquid denture cleaning composition - Google Patents
Liquid denture cleaning composition Download PDFInfo
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- JP2023049566A JP2023049566A JP2021159371A JP2021159371A JP2023049566A JP 2023049566 A JP2023049566 A JP 2023049566A JP 2021159371 A JP2021159371 A JP 2021159371A JP 2021159371 A JP2021159371 A JP 2021159371A JP 2023049566 A JP2023049566 A JP 2023049566A
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- 239000007788 liquid Substances 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 60
- 238000004140 cleaning Methods 0.000 title claims abstract description 11
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 58
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 29
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 29
- 235000019502 Orange oil Nutrition 0.000 claims abstract description 20
- 239000010502 orange oil Substances 0.000 claims abstract description 20
- 239000000253 Denture Cleanser Substances 0.000 claims description 59
- 239000006260 foam Substances 0.000 claims description 14
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 abstract description 8
- -1 fatty acid glycerol ester Chemical class 0.000 description 16
- 230000001954 sterilising effect Effects 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 10
- 238000003860 storage Methods 0.000 description 9
- 239000002280 amphoteric surfactant Substances 0.000 description 8
- 239000003945 anionic surfactant Substances 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
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- 239000002736 nonionic surfactant Substances 0.000 description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
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- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 239000001965 potato dextrose agar Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 1
- GMGBBMQOXFAWRS-UHFFFAOYSA-N 2-[2,2-diaminoethyl(tetradecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCN(CC(N)N)CC(O)=O GMGBBMQOXFAWRS-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000006819 Denture Stomatitis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- ATFFFUXLAJBBDE-FQEVSTJZSA-N N-Stearoyl glutamic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O ATFFFUXLAJBBDE-FQEVSTJZSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 206010035669 Pneumonia aspiration Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Natural products NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 201000009807 aspiration pneumonia Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
Description
本発明は、優れた除菌効果を有する液体義歯洗浄剤組成物に関する。 TECHNICAL FIELD The present invention relates to a liquid denture cleanser composition having an excellent disinfecting effect.
義歯に付着する汚れには、デンチャープラーク、食物残渣、ステイン（着色沈着物）、歯石等がある。義歯に付着する汚れの内、デンチャープラークは、歯周病、義歯性口内炎、カンジダ症、誤嚥性肺炎等を助長又は誘発することが指摘されており、義歯に付着したデンチャープラークを除去して義歯を清潔に保つことが義歯使用者の健康維持の上で重要になっている。 Dirt adhering to dentures includes denture plaque, food residue, stain (colored deposits), tartar, and the like. Among the stains that adhere to dentures, it has been pointed out that denture plaque promotes or induces periodontal disease, denture stomatitis, candidiasis, aspiration pneumonia, etc. Keeping dentures clean is important for maintaining the health of denture wearers.
義歯に付着したデンチャープラークは、ブラシによる清掃では十分に除去できないため、除菌効果を有する義歯洗浄剤を用いた洗浄が重要になる。従来、除菌効果を有する義歯洗浄剤について、種々検討されている。 Since denture plaque adhering to dentures cannot be sufficiently removed by cleaning with a brush, cleaning with a denture cleanser having a disinfecting effect is important. Conventionally, various studies have been made on denture cleansing agents having a sterilizing effect.
例えば、特許文献１には、Ｎ－ステアロイル－Ｌ－グルタミン酸の抗菌性金属塩を０．００２５重量％超の配合量で含む義歯洗浄剤組成物は、殺菌力に優れ、短時間で義歯を洗浄することができることが記載されている。また、特許文献２には、（Ａ）特定の脂肪酸又はその塩１５～４５重量％、（Ｂ）特定の脂肪酸グリセリンエステル２０～５０重量％、（Ｃ）スルホコハク酸エステル１０～３０重量％、（Ｄ）特定のアルコール０～１０重量％、（Ｅ）水０～５５重量％を少なくとも含む溶液１重量部に対し、水性基剤を１～５００重量部の比率で混合してなる組成物は、優れた抗菌活性を示し、義歯用抗菌剤として使用できることが記載されている。 For example, in Patent Document 1, a denture cleanser composition containing an antibacterial metal salt of N-stearoyl-L-glutamic acid in an amount exceeding 0.0025% by weight has excellent sterilizing power and cleans dentures in a short time. It states that it can be done. In addition, in Patent Document 2, (A) 15 to 45% by weight of a specific fatty acid or a salt thereof, (B) 20 to 50% by weight of a specific fatty acid glycerol ester, (C) 10 to 30% by weight of a sulfosuccinate ester, ( D) A composition obtained by mixing 1 part by weight of a solution containing at least 0 to 10% by weight of a specific alcohol and (E) 0 to 55% by weight of water with an aqueous base in a ratio of 1 to 500 parts by weight, It is described that it exhibits excellent antibacterial activity and can be used as an antibacterial agent for dentures.
従来、義歯洗浄剤に配合可能な除菌成分として安息香酸（フリー体）が知られている。安息香酸は、義歯洗浄剤において除菌成分として汎用されている安息香酸ナトリウムに比べて水に対する溶解度が顕著に低いという欠点があるが、安息香酸ナトリウムよりも除菌作用が高いことが知られており、安息香酸による除菌効果を更に向上させた義歯洗浄剤を開発できれば、優れたデンチャープラーク除去効果が期待できる。 Conventionally, benzoic acid (free form) is known as a sterilizing component that can be blended in denture cleaners. Benzoic acid has the disadvantage that its solubility in water is significantly lower than that of sodium benzoate, which is widely used as a disinfecting ingredient in denture cleansers, but it is known to have a higher disinfecting effect than sodium benzoate. Therefore, if we can develop a denture cleanser that further improves the sterilization effect of benzoic acid, we can expect an excellent denture plaque removal effect.
そこで、本発明は、安息香酸を含み、優れた除菌効果を有する液体義歯洗浄剤組成物を提供することを目的とする。 Accordingly, an object of the present invention is to provide a liquid denture cleanser composition containing benzoic acid and having an excellent disinfecting effect.
本発明者は、前記課題を解決すべく鋭意検討を行ったところ、液体義歯洗浄剤組成物において、安息香酸と共にオレンジ油を配合することによって、格段に優れた除菌効果を備え得ることを見出した。更に、本発明者は、安息香酸とオレンジ油を含む液体義歯洗浄剤組成物について検討を進めたところ、当該液体義歯洗浄剤組成物に更にジプロピレングリコールを配合することにより、保存による析出物の生成を抑制し、優れた保存安定性を備え得ることをも見出した。本発明は、これらの知見に基づいて、更に検討を重ねることにより完成したものである。 The present inventor conducted intensive studies to solve the above-mentioned problems, and found that a liquid denture cleanser composition containing orange oil together with benzoic acid can have a remarkably excellent sterilization effect. rice field. Furthermore, the present inventors have investigated a liquid denture cleanser composition containing benzoic acid and orange oil, and found that by further blending dipropylene glycol into the liquid denture cleanser composition, the deposits due to storage can be reduced. It was also found that the production can be suppressed and excellent storage stability can be provided. The present invention has been completed through further studies based on these findings.
即ち、本発明は、以下に掲げる態様の発明を提供する。
項１． 安息香酸、及びオレンジ油を含有する、液体義歯洗浄剤組成物。
項２． 更に、界面活性剤を含有する、項１に記載の液体義歯洗浄剤組成物。
項３． 更に、ジプロピレングリコールを含有する、項１又は２に記載の液体義歯洗浄剤組成物。
項４． 内容物を泡状で吐出させる容器に収容される、項１～３のいずれかに記載の液体義歯洗浄剤組成物。
項５． 項１～４のいずれかに記載の液体義歯洗浄剤組成物を用いて義歯を洗浄する、義歯の洗浄方法。
That is, the present invention provides inventions in the following aspects.
Section 1. A liquid denture cleanser composition containing benzoic acid and orange oil.
Section 2. Item 1. The liquid denture cleanser composition according to Item 1, further comprising a surfactant.
Item 3. Item 3. The liquid denture cleanser composition according to Item 1 or 2, further containing dipropylene glycol.
Section 4. Item 4. The liquid denture cleanser composition according to any one of Items 1 to 3, which is contained in a container that discharges the contents in the form of foam.
Item 5. Item 5. A method for cleaning dentures, comprising cleaning dentures using the liquid denture cleanser composition according to any one of items 1 to 4.
本発明の液体義歯洗浄剤組成物は、安息香酸とオレンジ油を組み合わせて含むことにより、除菌効果を飛躍的に向上させることができる。また、本発明の液体義歯洗浄剤組成物の一実施形態では、更にジプロピレングリコールを含むことにより、保存による析出物の生成を抑制し、優れた保存安定性を備えることができる。 By containing benzoic acid and orange oil in combination, the liquid denture cleanser composition of the present invention can dramatically improve the sterilization effect. Moreover, in one embodiment of the liquid denture cleanser composition of the present invention, by further containing dipropylene glycol, the formation of deposits during storage can be suppressed, and excellent storage stability can be provided.
本発明の液体義歯洗浄剤組成物は、安息香酸及びオレンジ油を含有することを特徴とする。以下、本発明の液体義歯洗浄剤組成物について詳述する。 The liquid denture cleanser composition of the present invention is characterized by containing benzoic acid and orange oil. The liquid denture cleanser composition of the present invention is described in detail below.
［安息香酸］
本発明の液体義歯洗浄剤組成物は、安息香酸を含む。本明細書において、単に「安息香酸」と記載している場合には、安息香酸のフリー体を指し、安息香酸ナトリウム等の塩の形態ではないことを意味する。
[benzoic acid]
The liquid denture cleanser composition of the present invention contains benzoic acid. In the present specification, the term "benzoic acid" simply refers to the free form of benzoic acid, not in the form of a salt such as sodium benzoate.
本発明の液体義歯洗浄剤組成物における安息香酸の含有量については、付与すべき除菌効果の程度等に応じて適宜設定すればよいが、例えば、０．０１～１０重量％、好ましくは０．１～５重量％、より好ましくは０．５～３重量％が挙げられる。 The content of benzoic acid in the liquid denture cleanser composition of the present invention may be appropriately set according to the degree of sterilization effect to be imparted. .1 to 5% by weight, more preferably 0.5 to 3% by weight.
［オレンジ油］
本発明の液体義歯洗浄剤組成物は、安息香酸に加えて、オレンジ油を含有する。オレンジ油とは、Citrus属諸種植物（Rutaceae）の食用に供する種類の果皮を圧搾して得た精油である。オレンジ油自体には除菌効果はないが、安息香酸とオレンジ油を併用することによって、除菌効果を飛躍的に向上させることができる。
[Orange oil]
The liquid denture cleanser composition of the present invention contains orange oil in addition to benzoic acid. Orange oil is an essential oil obtained by pressing the edible peels of the Citrus Rutaceae. Although orange oil itself does not have a sterilizing effect, the combined use of benzoic acid and orange oil can dramatically improve the sterilizing effect.
本発明の液体義歯洗浄剤組成物において、安息香酸とオレンジ油の比率としては、例えば、安息香酸１００重量部当たり、オレンジ油が１～１０００重量部、好ましくは１０～５００重量部、より好ましくは５０～２５０重量部が挙げられる。 In the liquid denture cleanser composition of the present invention, the ratio of benzoic acid to orange oil is, for example, 1 to 1000 parts by weight, preferably 10 to 500 parts by weight, more preferably 10 to 500 parts by weight of orange oil per 100 parts by weight of benzoic acid. 50 to 250 parts by weight.
本発明の液体義歯洗浄剤組成物における安息香酸の含有量として、例えば、０．０１～１０重量％、好ましくは０．１～５重量％、より好ましくは０．５～３重量％が挙げられる。 The content of benzoic acid in the liquid denture cleanser composition of the present invention is, for example, 0.01 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 0.5 to 3% by weight. .
［界面活性剤］
本発明の液体義歯洗浄剤組成物は、安息香酸とオレンジ油を可溶化させたり、界面活性化作用による化学的洗浄力を備えさせたりするために、界面活性剤が含まれていることが好ましい。
[Surfactant]
The liquid denture cleanser composition of the present invention preferably contains a surfactant in order to solubilize benzoic acid and orange oil and provide chemical detergency due to surface activation. .
本発明の液体義歯洗浄剤組成物に配合される界面活性剤の種類については、特に制限されず、非イオン性界面活性剤、両性界面活性剤、アニオン性界面活性剤、カチオン性界面活性剤のいずれであってもよい。 The type of surfactant to be blended in the liquid denture cleanser composition of the present invention is not particularly limited, and nonionic surfactants, amphoteric surfactants, anionic surfactants and cationic surfactants can be used. Either can be used.
非イオン性界面活性剤としては、例えば、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、グリセリン脂肪酸エステル、ポリグセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレンアルキルエーテル、レシチン誘導体等が挙げられる。これらの非イオン性界面活性剤の中でも、好ましくは、ポリオキシエチレン硬化ヒマシ油が挙げられる。また、ポリオキシエチレン硬化ヒマシ油におけるポリオキシエチレン鎖のエチレンオキサイドの付加モル数については、特に制限されないが、例えば、５～１００、好ましくは１０～８０、更に好ましくは２０～６０が挙げられる。 Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, glycerin fatty acid ester, polygcerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyethylene glycol fatty acid ester, poly Oxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit fatty acid esters, polyoxyethylene alkyl ethers, lecithin derivatives and the like. Among these nonionic surfactants, polyoxyethylene hydrogenated castor oil is preferred. The number of moles of ethylene oxide added to the polyoxyethylene chain in the polyoxyethylene hydrogenated castor oil is not particularly limited, but is, for example, 5 to 100, preferably 10 to 80, more preferably 20 to 60.
両性界面活性剤としては、具体的には、ヤシ油脂肪酸アミドプロピルベタイン、ラウリルジメチルアミノ酢酸ベタイン、ラウリルジメチルアミンオキシド、２-アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリウムベタイン、Ｎ－ラウリルジアミノエチルグリシン、Ｎ－ミリスチルジアミノエチルグリシン、Ｎ－アルキル－１－ヒドロキシエチルイミダゾリンベタインナトリウム、レシチン等が挙げられる。これらの両性界面活性剤の中でも、好ましくはヤシ油脂肪酸アミドプロピルベタインが挙げられる。 Specific examples of amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, lauryldimethylaminoacetic acid betaine, lauryldimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryl diaminoethylglycine, N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethylimidazoline betaine sodium, lecithin and the like. Among these amphoteric surfactants, coconut oil fatty acid amidopropyl betaine is preferred.
アニオン性界面活性剤としては、具体的には、ラウリル硫酸ナトリウム、ポリオキシエチレンラウリルエーテル硫酸ナトリウム、ミリスチル硫酸ナトリウム、Ｎ－ラウロイルサルコシン酸ナトリウム、Ｎ－ミリストリルサルコシン酸ナトリウム、ドデシルベンゼンスルホン酸ナトリウム、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸ナトリウム、ラウリルスルホ酢酸ナトリウム、α－オレフィンスルホン酸ナトリウム、Ｎ－パルミトイルグルタルミン酸ナトリウム、Ｎ－メチル－Ｎ－アシルタウリンナトリウム等が挙げられる。これらのアニオン性界面活性剤の中でも、好ましくはラウリル硫酸ナトリウムが挙げられる。 Specific examples of anionic surfactants include sodium lauryl sulfate, sodium polyoxyethylene lauryl ether sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-mystryl sarcosinate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutarate, sodium N-methyl-N-acyl taurine; Among these anionic surfactants, sodium lauryl sulfate is preferred.
カチオン性界面活性剤としては、具体的には、塩化ラウリルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、塩化ベンゼトニウム、塩化ベンザルコニウム、塩化ステアリルジメチルベンジルアンモニウム等が挙げられる。 Specific examples of cationic surfactants include lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, benzethonium chloride, benzalkonium chloride, and stearyldimethylbenzylammonium chloride.
これらの界面活性剤は、１種単独で使用してもよく、２種以上を組み合わせて使用してもよい。 These surfactants may be used singly or in combination of two or more.
本発明の液体義歯洗浄剤組成物の好適な実施形態として、非イオン性界面活性剤、両性界面活性剤、及びアニオン性界面活性剤を組み合わせて含むことが挙げられる。本発明の液体義歯洗浄剤組成物において、非イオン性界面活性剤、両性界面活性剤、及びアニオン性界面活性剤を含有させる場合、これらの比率については、特に制限されないが、例えば、非イオン性界面活性剤１００重量部当たり、両性界面活性剤が０．１～１０００重量部、アニオン性界面活性剤が１～１００００重量部；好ましくは両性界面活性剤が１０～１０００重量部、アニオン性界面活性剤が１０～１０００重量部；より好ましくは両性界面活性剤が１０～１００重量部、アニオン性界面活性剤が５０～２５０重量部が挙げられる。 A preferred embodiment of the liquid denture cleanser composition of the present invention includes a nonionic surfactant, an amphoteric surfactant and an anionic surfactant in combination. When the liquid denture cleanser composition of the present invention contains a nonionic surfactant, an amphoteric surfactant, and an anionic surfactant, the ratio of these is not particularly limited. 0.1 to 1000 parts by weight of amphoteric surfactant and 1 to 10000 parts by weight of anionic surfactant per 100 parts by weight of surfactant; preferably 10 to 1000 parts by weight of amphoteric surfactant and anionic surfactant 10 to 1000 parts by weight of the agent; more preferably 10 to 100 parts by weight of the amphoteric surfactant and 50 to 250 parts by weight of the anionic surfactant.
本発明の液体義歯洗浄剤組成物に界面活性剤を含有させる場合、安息香酸と界面活性剤との比率については、特に制限されないが、例えば、安息香酸１００重量部当たり、界面活性剤が総量で１～１００００重量部、好ましくは１０～１０００重量部、より好ましくは２００～３０００重量部が挙げられる。 When the liquid denture cleanser composition of the present invention contains a surfactant, the ratio between benzoic acid and the surfactant is not particularly limited. 1 to 10000 parts by weight, preferably 10 to 1000 parts by weight, more preferably 200 to 3000 parts by weight.
また、本発明の液体義歯洗浄剤組成物に界面活性剤を含有させる場合、界面活性剤の含有量については、特に制限されないが、例えば、界面活性剤の総量で、０．０１～３０重量％、好ましくは０．１～２０重量％、より好ましくは１～１５重量％が挙げられる。 When the liquid denture cleanser composition of the present invention contains a surfactant, the content of the surfactant is not particularly limited, but for example, the total amount of the surfactant is 0.01 to 30% by weight. , preferably 0.1 to 20% by weight, more preferably 1 to 15% by weight.
［ジプロピレングリコール］
本発明の液体義歯洗浄剤組成物は、更にジプロピレングリコールを含んでいてもよい。本発明の液体義歯洗浄剤組成物においてジプロピレングリコールが含まれている場合には、保存による析出物の生成を抑制し、優れた保存安定性を備えることが可能になる。
[Dipropylene glycol]
The liquid denture cleanser composition of the present invention may further contain dipropylene glycol. When dipropylene glycol is contained in the liquid denture cleanser composition of the present invention, it is possible to suppress the formation of deposits during storage and to provide excellent storage stability.
本発明の液体義歯洗浄剤組成物にジプロピレングリコールを含有させる場合、安息香酸とジプロピレングリコールとの比率については、特に制限されないが、例えば、安息香酸１００重量部当たり、ジプロピレングリコールが１～１００００重量部、好ましくは１０～５０００重量部、より好ましくは２００～２０００重量部が挙げられる。 When the liquid denture cleanser composition of the present invention contains dipropylene glycol, the ratio between benzoic acid and dipropylene glycol is not particularly limited. 10000 parts by weight, preferably 10 to 5000 parts by weight, more preferably 200 to 2000 parts by weight.
また、本発明の液体義歯洗浄剤組成物にジプロピレングリコール剤を含有させる場合、ジプロピレングリコールの含有量については、特に制限されないが、例えば、０．０１～３０重量％、好ましくは０．１～２０重量％、より好ましくは１～１５重量％、更に好ましくは２～１０重量％が挙げられる。 When the liquid denture cleanser composition of the present invention contains a dipropylene glycol agent, the content of dipropylene glycol is not particularly limited, but is, for example, 0.01 to 30% by weight, preferably 0.1%. to 20% by weight, more preferably 1 to 15% by weight, and even more preferably 2 to 10% by weight.
［グリセリン］
本発明の液体義歯洗浄剤組成物は、更にグリセリンを含んでいてもよい。本発明の液体義歯洗浄剤組成物にグリセリンを含有させる場合、グリセリンの含有量については、特に制限されないが、例えば、０．１～４０重量％、好ましくは０．５～３０重量％、より好ましくは１～１５重量％、更に好ましくは５～２０重量％が挙げられる。
[Glycerin]
The liquid denture cleanser composition of the present invention may further contain glycerin. When the liquid denture cleanser composition of the present invention contains glycerin, the content of glycerin is not particularly limited, but is, for example, 0.1 to 40% by weight, preferably 0.5 to 30% by weight, and more preferably. is 1 to 15% by weight, more preferably 5 to 20% by weight.
［その他の成分］
本発明の義歯洗浄剤には、前記成分の他に、本発明の効果を妨げないことを限度として、必要に応じて、キレート剤、酵素、着色料、甘味料、消臭剤、発泡安定化剤、保存剤、漂白剤、抗菌剤、殺菌剤、防腐剤、ｐＨ調整剤等の添加剤を含んでいてもよい。これらの添加剤は、１種単独で配合してもよく、２種以上を任意に組み合わせて配合してもよい。
[Other ingredients]
In addition to the above components, the denture cleanser of the present invention may optionally contain a chelating agent, an enzyme, a coloring agent, a sweetener, a deodorant, and a foam stabilizer as long as the effects of the present invention are not impaired. Additives such as agents, preservatives, bleaching agents, antibacterial agents, bactericidal agents, preservatives, and pH adjusters may be included. These additives may be blended singly or in any combination of two or more.
また、本発明の液体義歯洗浄剤組成物は、液状であるため、前述する成分以外の残部は水になる。 In addition, since the liquid denture cleanser composition of the present invention is liquid, the balance other than the components described above is water.
［容器］
本発明の液体義歯洗浄剤組成物を収容する容器のタイプについては、特に制限されないが、好適な一例として、内容物を泡状で吐出させる容器が挙げられる。当該容器に本発明の液体義歯洗浄剤組成物を収容して使用することにより、義歯に対して本発明の液体義歯洗浄剤組成物を泡状にして接触させることができ、簡便に義歯を洗浄することが可能になる。
[container]
The type of container for containing the liquid denture cleanser composition of the present invention is not particularly limited, but a preferred example is a container that discharges the contents in the form of foam. By storing and using the liquid denture cleanser composition of the present invention in the container, the liquid denture cleanser composition of the present invention can be foamed and brought into contact with the dentures, and the dentures can be easily cleaned. it becomes possible to
内容物を泡状で吐出させる容器としては、具体的には、ポンプフォーマー容器が挙げられる。ポンプフォーマー容器、スクイズフォーマー容器等が挙げられる。ポンプフォーマー容器とは、手押しポンプの圧力により容器本体内の内容物を泡状に吐出させる泡吐出容器である。スクイズフォーマー容器とは、可撓性を有する容器本体を押圧することにより容器本体内の内容物を泡状に吐出させる泡吐出容器である。内容物を泡状で吐出させる容器として、好ましくはポンプフォーマー容器が挙げられる。 A specific example of a container for discharging contents in the form of foam is a pump foamer container. A pump foamer container, a squeeze foamer container and the like can be mentioned. A pump foamer container is a foam discharge container that discharges the contents in a container body in the form of foam by the pressure of a hand pump. A squeeze foam container is a foam discharge container that discharges the contents in a container body in the form of foam by pressing a flexible container body. A pump foamer container is preferably used as a container for discharging contents in foam form.
[使用方法]
本発明の液体義歯洗浄剤組成物の洗浄対象となる義歯は、総義歯又は部分床義歯（部分入れ歯）のいずれであってもよい。
[how to use]
Dentures to be cleaned with the liquid denture cleanser composition of the present invention may be full dentures or partial dentures (partial dentures).
本発明の液体義歯洗浄剤組成物を用いて義歯を洗浄するには、本発明の液体義歯洗浄剤組成物を義歯に接触させてばよい。具体的には、内容物を泡状に吐出させる泡吐出容器を用いて本発明の液体義歯洗浄剤組成物を泡状にして義歯に接触させる方法；本発明の液体義歯洗浄剤組成物を撹拌等の手段により泡立てて義歯に接触させる方法；本発明の液体義歯洗浄剤組成物を液状のままで義歯を浸漬させる方法等が挙げられる。本発明の液体義歯洗浄剤組成物を義歯に接触させる時間については、義歯の汚れの程度等に応じて適宜設定すればよいが、例えば、１分間程度以上、好ましくは１～５分間程度が挙げられる。また、義歯の洗浄中には、必要に応じてブラシ等の洗浄具で義歯を擦り洗いしてもよい。 In order to clean dentures using the liquid denture cleanser composition of the present invention, the liquid denture cleanser composition of the present invention may be brought into contact with the dentures. Specifically, a method of foaming the liquid denture cleanser composition of the present invention into foam and contacting the dentures using a foam discharge container for discharging the contents in the form of foam; stirring the liquid denture cleanser composition of the present invention. and the like; and a method of immersing the dentures in the liquid state of the liquid denture cleanser composition of the present invention. The time for which the liquid denture cleanser composition of the present invention is brought into contact with the dentures may be appropriately set according to the degree of staining of the dentures. be done. Also, during cleaning of the dentures, the dentures may be scrubbed with a cleaning tool such as a brush, if necessary.
以下の実施例を示し、本発明を具体的に説明する。但し、本発明はこれらに限定されない。 The following examples are presented to illustrate the present invention. However, the present invention is not limited to these.
試験例１：除菌効果の評価
表１に示す液体義歯洗浄剤組成物を調製した。得られた液体義歯洗浄剤組成物は、いずれも調製直後に析出物は認められなかった。
Test Example 1: Evaluation of disinfecting effect A liquid denture cleanser composition shown in Table 1 was prepared. No precipitate was observed in any of the resulting liquid denture cleanser compositions immediately after preparation.
得られた液体義歯洗浄剤組成物について、以下に記載する方法で除菌効果を評価した。カンジダ菌（Ｃａｎｄｉｄａ ａｌｂｉｃａｎｓ）（ＮＢＲＣ１５９４)をＰＤＡ培地（ポテトデキストロース寒天培地）で培養し、培養菌体を無菌的に採取して、Ｏ．Ｄ．６００が０．７０～０．７５になるように生理食塩水で希釈して菌液を調製した。得られた菌液１ｍｌと液体義歯洗浄剤組成物又は滅菌蒸留水１ｍｌとを混合して室温で１分間静置し、その後、ＳＣＤＬＰ培地（レシチン及びポリソルベート８０含有ソイビーン・カゼイン・ダイジェスト培地）３０ｍｌを加え、サンプル液を得た。次いで、得られたサンプル液を適切に希釈し、ＧＰＬＰ寒天培地（レシチン及びポリソルベート８０含有グルコースペプトン観点培地）上に塗抹し、培養後、形成されたコロニーをカウントした。コロニー数と希釈倍率から、各サンプル液中のカンジダ菌の菌数を求め、以下の式に従って、除菌率を算出した。
結果を表１に示す。比較例３及び５の結果から、オレンジ油は単独では除菌効果を示さないことが確認された。また、オレンジ油を含まず、安息香酸を含む場合には、安息香酸及びオレンジ油の双方を含まない場合に比べて、除菌率の向上は認められるものの、除菌率が９８％以上には達していなかった。これに対して、安息香酸とオレンジ油を組み合わせて含む場合には、略１００％の除菌率が認められ、除菌効果が飛躍的に向上していた。なお、実施例１～５及び比較例１～５において、グリセリンを含まない組成変更を行って同様の手法で除菌効果を評価したところ、グリセリンの有無によって除菌効果は殆ど影響を受けないことが確認された。 Table 1 shows the results. From the results of Comparative Examples 3 and 5, it was confirmed that orange oil alone did not exhibit a bactericidal effect. In addition, when orange oil is not included and benzoic acid is included, although the sterilization rate is improved compared to the case where both benzoic acid and orange oil are not included, the sterilization rate is 98% or more. had not reached. On the other hand, when benzoic acid and orange oil are contained in combination, a sterilization rate of approximately 100% was observed, and the sterilization effect was dramatically improved. In addition, in Examples 1 to 5 and Comparative Examples 1 to 5, when the composition was changed without glycerin and the sterilization effect was evaluated by the same method, it was found that the sterilization effect was hardly affected by the presence or absence of glycerin. was confirmed.
試験例２：保存安定性の評価
前記実施例２及び５～８の液体義歯洗浄剤組成物について、保存安定性を評価した。具体的には、調製直後の各液体義歯洗浄剤組成物１０ｍｌを透明ガラス容器に充填して密封し、－２０℃で１２時間保持した後に５℃まで昇温させて１２時間保持することを１サイクルとする低温サイクル試験を合計１０日間（１０サイクル）行った。低温サイクル試験後の液体義歯洗浄剤組成物の外観を観察し、析出物の有無を評価した。
Test Example 2: Evaluation of Storage Stability The liquid denture cleanser compositions of Examples 2 and 5 to 8 were evaluated for storage stability. Specifically, 10 ml of each liquid denture cleanser composition immediately after preparation is filled in a transparent glass container, sealed, held at −20° C. for 12 hours, then heated to 5° C. and held for 12 hours. A low-temperature cycle test was performed for a total of 10 days (10 cycles). The appearance of the liquid denture cleanser composition after the low-temperature cycle test was observed to evaluate the presence or absence of deposits.
結果を表２に示す。この結果から、安息香酸とオレンジ油に加えて、ジプロピレングリコールを含有させた場合には、低温サイクル試験後でも析出物の生成を抑制できており、優れた保存安定性を備え得ることが明らかとなった。 Table 2 shows the results. From this result, it is clear that when dipropylene glycol is added in addition to benzoic acid and orange oil, the formation of precipitates can be suppressed even after the low temperature cycle test, and excellent storage stability can be achieved. became.
Claims (5)
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| JP2021159371A JP2023049566A (en) | 2021-09-29 | 2021-09-29 | Liquid denture cleaning composition |
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| JP2021159371A JP2023049566A (en) | 2021-09-29 | 2021-09-29 | Liquid denture cleaning composition |
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| JP2023049566A true JP2023049566A (en) | 2023-04-10 |
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