JP2010280588A - Coating-type liquid denture cleanser composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid denture cleanser composition that enables easy cleaning of the denture when applied to the denture in use and subsequently removed therefrom e.g. by soaking of the denture in water, is excellent in stain-removing effect and antiseptic effect of a denture-soaking liquid, shows high shelf stability and is capable of readily and effectively cleaning the denture and keeping the same clean. <P>SOLUTION: The coating-type liquid denture cleanser composition includes (A) 0.2-3.0 mass% nonionic surfactant, (B) 0.1-2.0 mass% cationic bactericide, (C) 0.5-4.0 mass% sulfite and (D) a water-soluble polymer substance, provided that the mass ratio of component (A) to (B) is 0.3-15, while the total amount of components (B) and (C) is within the range of 0.6-5.0 mass%, and the pH at 25°C is 6.0-8.5. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention is applied and applied to a denture, and by simply immersing the denture in water after application, it is excellent in removal power against coloring stains of the denture and antiseptic power of the immersion liquid, and good appearance stability. It is related with the application | coating type liquid composition for denture washing | cleaning suitable for application | coating to a denture.

  In recent years, with the arrival of an aging society, the number of denture users tends to increase year by year. Denture users cannot easily care for dentures, and dirt tends to accumulate in the dentures and the oral cavity, and as a result, they feel various problems with dentures. One example is denture dirt. Representative examples of denture stains that a denture wearer cares about include slime stains derived from denture biofilms (denture plaques), colored stains (stains, tobacco stains), denture odors, tartar and the like.

  As a method for removing denture dirt, there are mechanical removal by brushing and chemical removal by use of a denture cleaning agent and a polishing agent. However, it is difficult to completely remove the dirt adhering to the narrow gap and denture surface only by mechanical removal by brushing. Therefore, in order to effectively remove denture dirt, mechanical removal and chemical removal are effective. It is desirable to use the two methods in combination.

  From the viewpoint of chemical removal, “degradation / removal” and “bleaching” for colored stains, and “sterilization / antibacterial” and “removal” approaches for the purpose of sterilizing denture biofilms and denture odors There is a law.

  The denture cleaners currently on the market are mainly solid type, especially tablet type. Surfactants and chelating agents (ethylene diamine tetraacetate (EDTA), polyphosphate, etc.), bleaching agents (percarbonate, percarbonate) Peroxides such as borates) and proteolytic enzymes (proteases, etc.) are blended as cleaning ingredients, and peroxides such as percarbonate and perborate are bleached by hydrogen peroxide generated during use. , Which demonstrates sterilization.

  However, since the active ingredient is a peroxide, attention must be paid in terms of harmfulness to denture metals. In addition, the above-described solid-type cleaning agent has a problem in terms of usability because it is difficult to adjust the usage amount according to the liquid amount. In particular, tablet-type cleaning agents are packaged in a single unit, and the user is dissatisfied in terms of adjusting the amount of use for cleaning partial dentures whose denture size varies greatly among users. Yes. Solid-type cleaning agents have such problems, whereas liquid or liquid preparations have the advantage that the amount used can be easily adjusted.

  In addition, abrasives blended in general dentifrices are very effective in removing denture biofilms and colored stains, and in general, general dentifrices may be used for cleaning and caring for dentures. . However, the abrasive compounded in a general dentifrice has the problem that not only the resin resin of the denture is damaged, but microorganisms are fixed and propagated on the damaged resin surface to promote the formation of a biofilm.

  Therefore, these problems can be solved, the amount used can be adjusted according to the size of the denture, the denture can be cleaned without using a peroxide or abrasive, and it is liquid type and excellent against stain stains on the denture Development of a denture cleaning composition that exhibits an excellent removal effect is desired.

  In order to remove colored stains on dentures, it is effective to add a bleaching component having a redox ability such as a peroxide such as hydrogen peroxide or a sulfite. Patent Documents 1 and 2 (see Japanese Patent Application Laid-Open Nos. 2003-96579 and 2003-313585) propose techniques for blending sulfites with a denture cleaning composition. In the liquid dosage form, it is not recognized that the stability of the composition can be maintained while exhibiting sufficient stain removability and the preservative power of the denture immersion liquid.

  On the other hand, if the denture biofilm remains on the denture surface when it is immersed and stored at bedtime, a denture odor is generated due to the growth of microorganisms. Therefore, it is important to give the soaking solution antiseptic (antibacterial activity). For this purpose, it is indispensable to add a disinfectant (antibacterial agent) to the cleaning agent, and among them, a cationic disinfectant is effective.

  Here, a surfactant is usually added to give cleaning power to denture stains such as stains or solubilize oily components such as fragrances, but an anionic surfactant was added. In some cases, a complex is formed with the cationic fungicide, and the efficacy of the cationic fungicide is reduced or eliminated. For this purpose, a nonionic surfactant is usually used as the surfactant. However, if the amount of the nonionic surfactant is increased in order to improve the dirt removing effect, the efficacy is reduced or lost because the bactericide is incorporated into the micelle. For this reason, an appropriate surfactant is used so as not to inhibit the efficacy of the disinfectant as much as possible while exhibiting soil removability, and the amount of the surfactant and the compounding ratio of the surfactant to the cationic disinfectant are appropriately set. Setting is important.

  Many oral compositions containing a cationic bactericidal agent and a nonionic surfactant have been proposed (Patent Documents 3 to 6; JP-A-4-173728, JP-A-7-215830, Patent 3660169). Gazette, JP-A-11-255629).

  However, with these compositions, it is difficult to achieve both sufficient stain removability and antiseptic power during denture immersion. The applicant has also proposed a concentrated denture cleaning liquid composition containing a cationic bactericidal agent, a nonionic surfactant, and a protease (see Patent Document 7; Japanese Patent Application Laid-Open No. 2008-179615). This composition is a liquid composition that is diluted with water and washed by immersing the denture at the time of use, and is not suitable for use in which a denture cleaning agent is applied directly to the surface of the denture, and is excellent for denture biofilms. However, it is difficult to obtain a sufficient effect for stain removal.

  Therefore, the amount used can be adjusted according to the size of the denture, it is a liquid type composition that does not contain peroxides or abrasives, it can be easily applied to the denture, and the stain removal effect of the denture and the immersion during denture immersion There is a demand for a denture cleaning liquid composition having sufficient antiseptic properties of liquid and having good appearance stability even during high temperature storage and low temperature storage.

JP 2003-96579 A Japanese Patent Laid-Open No. 2003-313685 JP-A-4-173728 JP 7-215830 A Japanese Patent No. 3660169 JP-A-11-255629 JP 2008-179615 A

  The present invention has been made in view of the above circumstances, and is a liquid-type denture cleaning composition that can be used according to the size of the denture when applied to a denture, and is used when applied to a denture In addition to its excellent properties (shape retention, dispersibility, ease of rubbing), it has both the ability to remove denture from stain stains and the preservative power of the immersion liquid when immersed in dentures, and the appearance when stored at high and low temperatures An object of the present invention is to provide a coating-type denture cleaning liquid composition having excellent stability.

  As a result of intensive research to achieve the above object, the present inventors formulated a nonionic surfactant, a cationic bactericidal agent, a sulfite, and a water-soluble polymer substance. Applying to the dentures by adjusting the mixing amount of the basic disinfectant and sulfite, the mixing ratio of the nonionic surfactant and the cationic disinfectant, and the total combining amount of the cationic disinfectant and sulfite within an appropriate range. In particular, it can be washed by immersing the denture after application in water, and it has excellent usability when applied and applied to the denture, and it adheres uniformly and widely over the denture surface. In addition, it has high removal power for denture stains and excellent antiseptic power of immersion liquid when applied to dentures and immersed in water after application. Even under Having good appearance stability, it found that it is possible to obtain a denture cleaning liquid composition of the coating type, the present invention has been accomplished.

  The applicant has disclosed a Japanese patent application 2008-329748 for a denture cleaning liquid composition containing a surfactant, sulfite, and a water-soluble polyphosphate, and having a specific ratio of sulfite and water-soluble polyphosphate. This is a liquid composition that can be applied to dentures in the form of liquid or foam. It is formulated with cationic disinfectants and water-soluble polymer substances such as xanthan gum, carboxymethyl cellulose, and hydroxyethyl cellulose. The composition is not shown either, and in any case, the technical idea is different from the present invention.

In the present invention, the polyoxyethylene alkyl ether having an average added mole number of ethylene oxide as the nonionic surfactant of 10 to 20 moles and the alkyl group having 12 to 16 carbon atoms, the fatty acid residue having 10 to 10 carbon atoms. 16, polyglycerol fatty acid monoester having an average degree of polymerization of 8 to 12, and polyoxyethylene polyoxypropylene glycol having an average degree of polymerization of ethylene oxide of 180 to 220 mol and an average degree of polymerization of propylene oxide of 60 to 80 mol When one or more selected from the above are used, the removal power against stain can be further improved.
Furthermore, the removal power with respect to a stain can be further strengthened by mix | blending (E) water-soluble polyphosphate.
Furthermore, (F) By mix | blending a specific oil-soluble fragrance | flavor, the use feeling (smooth feeling) excellent at the time of denture mounting | wearing can also be exhibited.

The viscosity of the composition is preferably 2,000 to 50,000 mPa · s at 25 ° C. measured using a B-type viscometer.
In addition, the composition of the present invention has no problem such as harm to denture metal due to being a liquid composition not containing a peroxide. The resin resin is not damaged.
The composition of the present invention can effectively clean the denture by adopting a method in which the denture is immersed in water and washed after application to the denture.

Accordingly, the present invention provides the following application-type denture cleaning liquid composition.
Claim 1;
(A) a nonionic surfactant, (B) a cationic fungicide, (C) a sulfite, and (D) a water-soluble polymer substance, and the component (A) is added in an amount of 0.2 to 3. 0% by mass, 0.1 to 2.0% by mass of the component (B), 0.5 to 4.0% by mass of the component (C), and the mass ratio of (A) / (B) is 0.00. 3-15, the total compounding quantity of (B) and (C) component exists in the range of 0.6-5.0 mass%, and pH in 25 degreeC is 6.0-8.5, It is characterized by the above-mentioned. An application type liquid composition for cleaning dentures.
Claim 2;
(A) The nonionic surfactant is a polyoxyethylene alkyl ether having an average addition mole number of ethylene oxide of 10 to 20 moles and an alkyl group having 12 to 16 carbon atoms, and a fatty acid residue having 10 to 16 carbon atoms. Selected from polyglycerol fatty acid monoester having an average polymerization degree of 8 to 12 and polyoxyethylene polyoxypropylene glycol having an average polymerization degree of ethylene oxide of 180 to 220 mol and an average polymerization degree of propylene oxide of 60 to 80 mol. The liquid composition for denture cleaning according to claim 1, wherein the liquid composition is at least one kind.
Claim 3;
(D) The denture cleaning liquid composition according to claim 1 or 2, wherein the water-soluble polymer substance is a combination of xanthan gum and a cellulose polymer substance.
Claim 4;
(A) 0.5-1.5 mass% of component, (B) component 0.5-1.0 mass%, (C) component 1.0-2.0 mass%, and (A ) / (B) mass ratio is 1.0 to 4.0, the total blending amount of components (B) and (C) is in the range of 1.5 to 3.0 mass%, and pH at 25 ° C. 4. The application-type liquid composition for cleaning dentures according to claim 1, 2, or 3, wherein 7.0 is 8.0.
Claim 5:
Furthermore, (E) Water-soluble polyphosphate is contained, The liquid composition for denture cleaning of any one of Claims 1 thru | or 4 characterized by the above-mentioned.
Claim 6;
The denture according to any one of claims 1 to 5, further comprising (F) one or more oil-soluble fragrance ingredients selected from menthol, peppermint oil, peppermint oil and spearmint oil. Liquid composition for cleaning.
Claim 7;
The denture cleaning liquid composition according to any one of claims 1 to 6, wherein the viscosity at 25 ° C measured using a B-type viscometer is 2,000 to 50,000 mPa · s.
Claim 8;
The liquid composition for denture cleaning according to any one of claims 1 to 7, which does not contain a peroxide.
Claim 9;
The liquid composition for denture cleaning according to any one of claims 1 to 8, which does not contain an abrasive.
Claim 10;
The denture cleaning liquid composition according to any one of claims 1 to 9, wherein the denture is dipped in water and washed after being applied to the denture.

  The liquid composition for cleaning dentures of the present invention has excellent usability (mold retention, dispersibility, ease of rubbing) when applied to dentures, and excellent stain stains by using the dentures in water after application. The removal effect and the antiseptic power of the denture soaking solution are exhibited, the appearance stability is also good, and the denture can be easily and effectively cleaned and kept clean.

  Hereinafter, the present invention will be described in more detail. The denture cleaning liquid composition of the present invention is a coating-type denture cleaning liquid composition comprising (A) a nonionic surfactant and (B) a cationic sterilizing agent. Agent, (C) sulfite, (D) water-soluble polymer substance, and (E) water-soluble polyphosphate and / or (F) menthol, peppermint oil, peppermint oil, spearmint oil One or more selected oil-soluble perfume ingredients can be contained.

  In the present invention, (A) nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters such as polyoxyethylene sorbitan fatty acid ester, sugar alcohol fatty acid esters such as sucrose fatty acid ester, and alkylol amide. , Polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monolaurate, sorbitan fatty acid ester such as sorbitan monolaurate, glycerin fatty acid ester, polyglycerin fatty acid ester such as decaglyceryl monolaurate, polyoxyethylene glycerin fatty acid ester, polyethylene monolaurate Polyoxyethylene glycol fatty acid ester such as glycol, polyethylene glycol fatty acid ester, polyoxyethylene polyoxyp Block type polyalkylene glycol such as pyrene glycol, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, polyoxyethylene alkyl phenyl ether such as polyoxyethylene nonylphenyl ether, polyoxyethylene alkyl ether such as polyoxyethylene lauryl ether These can be used, and one of these can be used alone or in combination of two or more.

  As the nonionic surfactant, polyoxyethylene alkyl ether, polyglycerin fatty acid monoester, and block type polyalkylene glycol (particularly, polyoxyethylene polyoxypropylene glycol) are particularly preferable from the viewpoint of enhancing stain removability.

As the polyoxyethylene alkyl ether, the average added mole number of ethylene oxide (hereinafter abbreviated as EO) is 10 to 20 moles, and the alkyl group has 12 to 16 carbon atoms from the viewpoint of enhancing stain removability. Polyoxyethylene alkyl ether is preferred.
Examples of the polyoxyethylene alkyl ether include polyoxyethylene lauryl ether (EO average addition mole number 15), polyoxyethylene myristyl ether (EO average addition mole number 15), polyoxyethylene alkyl (C12,14) ether (EO). An average addition mole number of 15) can be used, and one of these can be used alone or in combination of two or more, but polyoxyethylene lauryl ether (EO average addition mole number of 15) is particularly preferably used. It is done. As these polyoxyethylene alkyl ethers, for example, commercially available products available from Japan Emulsion Co., Ltd., Lion Chemical Co., Ltd. and the like can be used.

As the polyglycerol fatty acid monoester, a polyglycerol fatty acid monoester having a fatty acid residue having 10 to 16 carbon atoms and an average degree of polymerization of 8 to 12 is particularly suitable.
Examples of the polyglyceryl fatty acid monoester include decaglyceryl caprylate, decaglyceryl laurate, decaglyceryl myristate, decaglyceryl palmitate, etc., and these may be used alone or in combination of two or more. In particular, decaglyceryl laurate is preferably used.
As these polyglyceryl fatty acid esters, decaglyceryl caprylate (Sunsoft Q-10Y), decaglyceryl laurate (Sunsoft M-12J), decaglyceryl laurate (Sunsoft Q-12Y) manufactured by Taiyo Kagaku Co., Ltd. ), Decaglyceryl myristate (Sunsoft Q-14Y), decaglyceryl laurate (L-10D), decaglyceryl laurate (L-7D), decaglyceryl myristate (M-10D) manufactured by Mitsubishi Chemical Foods Corporation These can be used alone or in combination of two or more.

Polyoxyethylene polyoxypropylene glycol is a block polymer type nonionic surfactant obtained by addition polymerization of ethylene oxide to polypropylene glycol obtained by polymerizing propylene oxide, and the average degree of polymerization of ethylene oxide is 180 to 220 mol. What the average degree of polymerization of a propylene oxide is 60-80 mol is suitable.
Specific examples of the polyoxyethylene polyoxypropylene glycol include polyoxyethylene (196) polyoxypropylene (67) glycol (numbers in parentheses indicate average degree of polymerization), Lutrol F-127, Poloxamer 407. Those sold by BASF Japan Ltd. under the trade names such as

  Component (A) is blended in an amount of 0.2 to the entire composition from the viewpoints of usability (dispersibility of agent, ease of rubbing), stain removability, antiseptic power of denture soaking solution, and appearance stability. It is 3.0% (mass%, the same shall apply hereinafter), preferably 0.5 to 1.5%. If it is less than 0.2%, the usability (dispersibility of agent, ease of rubbing) is inferior, and sufficient stain removing power is not exhibited. In addition, when an anionic polymer such as sodium carboxymethylcellulose, sodium alginate, xanthan gum is used as the water-soluble polymer, or when a water-insoluble disinfectant or oil-soluble fragrance is blended, the transparency decreases or precipitates. In some cases, the matter may be deposited or appearance stability may be problematic. If it exceeds 3.0%, the usability (ease of rubbing), the preservative power of the denture soaking solution and the stain removability will be reduced. Moreover, the feeling of use (a feeling of refreshing) at the time of denture installation may fall.

  Examples of (B) cationic bactericides include bisguanides such as chlorhexidine hydrochloride and chlorhexidine gluconate, and quaternary ammonium compounds such as benzethonium chloride, benzalkonium chloride and cetylpyridinium chloride. Ammonium compounds, particularly benzethonium chloride, benzalkonium chloride and cetylpyridinium chloride are preferred. Such cationic fungicides can be used alone or in combination of two or more.

  The blending amount of the (B) cationic bactericide is 0 with respect to the whole composition from the viewpoints of usability (dispersibility of the agent, ease of rubbing), antiseptic power of the denture soaking solution, stain removability, and appearance stability. 0.1 to 2.0%, preferably 0.5 to 1.0%. If it is less than 0.1%, sufficient antiseptic power of the denture soaking solution is not exhibited. If it exceeds 2.0%, the usability (ease of rubbing) and the stain removing power are reduced, and problems in appearance stability such as precipitation of insoluble matter and discoloration occur. Furthermore, the bitterness derived from a cationic fungicide becomes strong, and the feeling of use (a refreshing feeling) at the time of denture installation may fall.

  Furthermore, the mass ratio ((A) / (B)) of (A) nonionic surfactant and (B) cationic fungicide is 0.3 to 0.3 from the viewpoint of the antiseptic power and stain removability of the denture soaking solution. 15, preferably 1.0 to 4.0. If it is less than 0.3, sufficient stain removability is not exhibited. Moreover, the feeling of use (a feeling of refreshing) at the time of denture installation may fall. If it exceeds 15, the preservative power of the denture soaking solution is reduced.

(C) Sulphite is a component that exhibits a stain removal effect by its bleaching action, and also has a bactericidal action. The sulfite may be any compound that releases sulfite ions in an aqueous solution. Specifically, sodium sulfite, potassium sulfite, ammonium sulfite, sodium hydrogen sulfite, potassium hydrogen sulfite, ammonium hydrogen sulfite, sodium metabisulfite, Potassium metasulfite, ammonium metabisulfite, etc. can be mix | blended. (C) As a sulfite, sodium sulfite and sodium hydrogen sulfite are preferable from the viewpoint of stain removal ability and storage stability, and sodium sulfite is particularly preferably used.
Note that the object of the present invention cannot be achieved even if other components having a bleaching action, for example, peroxides such as percarbonate and perborate, are used instead of sulfite.

  (C) The blending amount of sulfite is 0.5 to 4.0%, preferably 1.0 to 2.0%, based on the entire composition, from the viewpoint of the ability to remove stain stains and appearance stability. . When the blending amount is less than 0.5%, a sufficient stain removing power is not exhibited. Even if it exceeds 4.0%, further improvement in the stain removal effect is not recognized, and problems in appearance stability such as precipitation of insoluble matters under low temperature storage occur.

  Furthermore, the total blending amount of (B) cationic bactericidal agent and (C) sulfite is 0.6- to the entire composition from the viewpoint of antiseptic power, stain removability, and appearance stability of the denture soaking solution. 5.0%, preferably 1.5-3.0%. If it is less than 0.6%, the effect of either or both of the preservative power and stain removability of the denture soaking solution will not be sufficiently exhibited. If it exceeds 5.0%, problems in appearance stability such as precipitation of precipitates occur.

  (D) As a water-soluble polymer substance, an organic substance that dissolves, disperses or swells in water or a polyhydric alcohol to form a viscous dispersion, and those that are usually used in oral compositions as a binder are used. Any of natural products, synthetic products and semi-synthetic products may be used. For example, carrageenan, methylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, xanthan gum, tragacanth gum, karaya gum, arabiya gum, locust bean gum, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, carbopol, beegum, gelatin, etc. Can be mentioned. Among them, it is preferable to use a cellulosic polymer substance such as xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose or the like. Even if it is a water-soluble polymer substance, polyols such as polyethylene glycol and polypropylene glycol are not suitable as the component (D) from the viewpoint of usability (shape retention) and are desirably not used.

  These water-soluble polymer substances may be used alone or in combination of two or more, but it is preferable to use in combination of two or more. When two or more types are used in combination, xanthan gum and a cellulose-based water-soluble polymer substance are considered from the viewpoints of usability (shape retention, ease of rubbing, dispersibility of the agent), stain removability, and antiseptic power of the denture soaking solution. It is more preferable to combine. The combination of the two types is preferably xanthan gum and carboxymethyl cellulose sodium, or a combination of xanthan gum and hydroxyethyl cellulose, and when three types are combined, the combined use of xanthan gum, sodium carboxymethyl cellulose and hydroxyethyl cellulose is preferred.

  (D) The amount of the water-soluble polymer substance is determined from the viewpoint of usability (shape retention, ease of rubbing, dispersibility of the agent), antiseptic power of the denture soaking solution, stain removal power and appearance stability. 0.2 to 5.0%, particularly 1.0 to 3.0% is preferable based on the whole. If it is less than 0.2%, the viscosity of the composition is low, so that the usability (shape retention) is inferior, and the amount of the composition attached at the time of coating is small, so the stain removal power and the preservative power of the immersion liquid are low. May decrease. If it exceeds 5.0%, not only the usability (ease of rubbing, the dispersibility of the agent) is deteriorated, but also the appearance stability and stain removal ability may be reduced.

  The denture cleaning liquid composition of the present invention contains the components (A) to (D) as described above, but can further contain (E) a water-soluble polyphosphate. The removal power can be further increased. In particular, when the blending amount of (A) nonionic surfactant is 0.2 to 0.4% or 1.6 to 3.0%, (B) the blending amount of the cationic bactericide is 1.1 to 2 0.0%, (C) when the amount of sulfite is 0.5 to 0.9%, or (D) when the amount of water-soluble polymer is 0.2 to 0.9% In such a case, when the mass ratio of (A) / (B) is 0.3 to 0.9, or when the pH of the composition is 6.0 to 6.9, etc., the stain removal power is enhanced. Therefore, it is preferable to further blend (E) a water-soluble polyphosphate.

The water-soluble polyphosphate is represented by the following general formula (1) from the viewpoint of improving stain removability and appearance stability.
M _{n + 2} P _n O _{3n + 1} (1)
(In the formula, M represents Na or K, and n is 2 or 3.)
The linear thing shown by these is used. For example, sodium pyrophosphate having a polymerization degree of n = 2 (produced by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.) or potassium pyrophosphate (produced by Taihei Chemical Sangyo Co., Ltd., Toa Gosei Chemical Co., Ltd.) , N = 3 sodium tripolyphosphate (manufactured by Central Glass Co., Ltd., Nippon Builder Co., Ltd., Taihei Chemical Industry Co., Ltd.), potassium tripolyphosphate (manufactured by Taihei Chemical Industrial Co., Ltd.), etc. Of these, sodium pyrophosphate and sodium tripolyphosphate are preferable, and sodium tripolyphosphate is particularly preferable from the viewpoint of stain removability. Moreover, water-soluble polyphosphate may be mix | blended independently or may be mix | blended combining 2 types.

  (E) When mix | blending water-soluble polyphosphate, the compounding quantity is 0.2 to 2.0% with respect to the whole composition from the point of the improvement effect of a stain removability, and the external appearance stability, Especially 0. 5 to 1.0% is preferable. If it is less than 0.2%, the effect of improving stain removability is not sufficiently exhibited, and if it exceeds 2.0%, problems in appearance stability such as insoluble matter precipitation may occur.

  In addition, when (E) a water-soluble polyphosphate is blended, the total blending amount of (B) a cationic fungicide, (C) sulfite, and (E) a water-soluble polyphosphate is the preservative power of the denture soaking solution, From the viewpoint of stain removability and appearance stability, 0.8 to 5.0%, particularly 1.5 to 3.0%, based on the entire composition is preferable. If it is less than 0.8%, the effects of either or both of the preservative power and stain removability of the denture soaking solution may not be sufficiently exhibited. If it exceeds 5.0%, the appearance stability such as insoluble matter precipitation may not be achieved. Problems may occur.

  The liquid composition for cleaning dentures of the present invention further comprises at least one selected from (F) menthol, peppermint oil, peppermint oil, and spearmint oil in order to give an excellent feeling of use (a refreshing feeling) when the denture is mounted. An oil-soluble fragrance can be blended. As these fragrance components, either natural fragrances or synthetic fragrances may be used.

  (F) When mix | blending the oil-soluble fragrance | flavor component of a component, the compounding quantity is 0.2-2.0 with respect to the whole composition from the point of the use feeling (smooth feeling) at the time of denture mounting | wearing, and an external appearance stability. %, Particularly 0.4 to 1.0% is preferable. If it is less than 0.2%, sufficient use feeling (smooth feeling) cannot be obtained when the denture is mounted. If it exceeds 2.0%, the actual feeling of use (smooth feeling) may be deteriorated, or the appearance stability of the composition may be problematic.

  In the denture cleaning liquid composition of the present invention, in addition to the above essential components, other known additives can be blended as necessary within a range not impairing the effects of the present invention. For example, surfactants other than the above, wetting agents, sweeteners, preservatives, active ingredients, pigments, fragrance ingredients, cleaning aids, etc. can be blended, these ingredients and a solvent such as water are mixed, and the usual method Can be manufactured. In addition, this invention composition does not contain the abrasive | polishing agent generally mix | blended with oral compositions, such as a dentifrice.

As the surfactant, in addition to the component (A), an anionic surfactant, an amphoteric surfactant, and (B) a cationic surfactant other than the cationic fungicide can be blended.
For example, as an anionic surfactant, amphoteric surfactants such as lauryl sulfate, lauroyl sarcosine salt, myristyl sarcosine salt, polyoxyethylene alkyl sulfate, N-lauroyl taurate, α-olefin sulfonate, Cationic surfactants such as fatty acid amidopropyl betaine, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine include lauryl pyridinium chloride, stearyl dimethyl benzyl ammonium chloride, distearyl chloride Dimethyl ammonium, cetyl trimethyl ammonium saccharin, stearyl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride, lauroyl colaminoform Methyl pyridinium, cetyltrimethylammonium bromide and the like.

  The blending amount of these surfactants is preferably 0 to 1.0% of the entire composition, and (A) the total blending amount of the surfactant including the nonionic surfactant is 0.2 to 0.2% of the entire composition. A range of 3.0% is preferred.

  As the wetting agent, polyhydric alcohol can be blended, sugar alcohols such as sorbitol, xylitol, erythritol, glycerin, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, 1,3-butylene glycol, reduced starch saccharified product 1 type, or 2 or more types can be used. The amount of the wetting agent is usually 3 to 50%, particularly 10 to 30% of the whole composition. If it is less than 3%, the composition stability is poor, and if it exceeds 50%, problems in appearance stability such as insoluble matter precipitation may occur.

  As sweeteners, saccharin sodium, aspartame, stevioside, stevia extract, etc., as preservatives, benzoic acid such as sodium benzoate or its salt, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid And paraoxybenzoic acid esters such as butyl.

  Various active ingredients include α-bisabolol, triclosan, isopropylmethylphenol, copper compounds such as copper gluconate, plant extracts such as zinc citrate, soft sugar beet extract, duckweed extract, chamomile, clove, rosemary, red gon, safflower And chelating agents such as ethylenediaminetetraacetate, enzymes such as polyphenol oxidase (also known as laccase), mutanase, lysozyme chloride, dextranase, and protease. In addition, it is not necessary to mix | blend peroxides, such as percarbonate and perborate. The compounding quantity of an active ingredient can be made into an effective quantity in the range which does not prevent the effect of this invention.

  As the fragrance, in addition to (F) menthol, peppermint oil, peppermint oil, spearmint oil, other fragrances may be blended within a range not impeding the effects of the present invention. For example, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel Natural fragrances such as oil, camomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute rose, orange flower, and the like Natural perfume processing (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powdered perfume, etc.), carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, Mole, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane Propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, dimethyl sulfide, cycloten, furfural, trimethyl pyrazine, ethyl lactate, methyl lactate, Single flavor such as ethylthioacetate, strawberry flavor, apple flavor, banana flavor Pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavors, include the blended fragrance such as tropical fruit flavors. The blending amount of the fragrance is within a range that does not hinder the effects of the present invention, and is usually preferably 0 to 1.0% of the entire composition.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 is exemplified.

  In the composition of the present invention, purified water is usually used as a solvent, but a lower alcohol such as ethanol can be blended as a solvent for the purpose of enhancing the solubility of hardly soluble components such as oil-soluble fragrances and isopropylmethylphenol. The blending amount of the lower alcohol is usually 1 to 10%, more preferably 1 to 5%, as long as the effects of the present invention are not hindered.

  The liquid composition for cleaning dentures of the present invention has a pH at 25 ° C. of 6.0 to 8.5, preferably 7.0 to 8.0, from the viewpoint of stain removability and appearance stability. When the pH at 25 ° C. is less than 6.0, sufficient stain removability cannot be exhibited. If it exceeds 8.5, discoloration of the composition is noticeable under high temperature storage, which may cause a problem in appearance stability.

In addition, you may mix | blend a pH adjuster as needed as a means of adjustment of pH. Examples of the pH adjuster include sodium hydroxide, hydrochloric acid, formic acid or a salt thereof, phosphoric acid or a salt thereof, citric acid or a salt thereof, sodium carbonate, sodium hydrogencarbonate, boric acid or a salt thereof. Among these, it is preferable to use sodium hydroxide, hydrochloric acid, phosphoric acid or a salt thereof, citric acid or a salt thereof. Examples of the phosphate include sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, trisodium phosphate and the like. Examples of the citrate include sodium citrate, calcium citrate, and tripotassium citrate.
The blending amount of these pH adjusters is only required to adjust the pH to the above range, and is usually 0.2 to 1.0% of the whole composition.

  The viscosity at 25 ° C. of the liquid composition is a B-type viscometer, in particular, a Brookfield viscometer (BH-type viscometer, rotor No.) from the viewpoint of the usability (shape retention, dispersibility, ease of rubbing) of the composition. .4-7, 20 rpm, after 3 minutes of rotation), 2,000-50,000 mPa · s, particularly 8,000-20,000 mPa · s are preferred. If it is less than 2,000 mPa · s, not only the usability (shape retention property, easiness of rubbing) is inferior, but also the viscosity of the composition is low, so the adhesiveness of the composition at the time of coating is low, and as a result, the stain removal ability And the preservative power of the immersion liquid may not be fully exhibited. When it exceeds 50,000 mPa · s, not only the usability (dispersibility and ease of rubbing) may be inferior, but also the stain removing power may not be sufficiently exhibited.

There is no restriction | limiting in particular as a container which accommodates the liquid composition for denture cleaning of this invention, Usually, the container applied to a composition for oral cavity can be used. Specifically, as a container, polyethylene layer, ethylene methacrylic acid copolymer layer, polyethylene terephthalate layer, aluminum layer, glass deposition layer, polyvinyl alcohol layer, ethylene vinyl alcohol copolymer layer, acrylonitrile copolymer layer, paper, recycling Laminate containers made of plastic layers, etc., polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc. can be used, tube-shaped containers, dispensers containers by mechanical or differential pressure, film packaging containers such as pillow packaging, etc. Various commonly used containers can be used. A tubular container and a dispenser container are preferred.
In this case, if a container having a narrow nozzle (about 1 to 4 mm in diameter) attached to the discharge part of the container, an appropriate amount of the composition can be easily discharged onto the denture surface or toothbrush.

  The liquid composition for cleaning dentures of the present invention is not diluted at the time of use, but is applied to the denture so that the whole or part of the denture is coated with the composition, and then the denture body is immersed in water, preferably for 30 minutes or more, preferably The denture can be cleaned by rinsing the liquid composition from the denture with water or hot water after leaving it to stand for 2 hours or more, more preferably 5 hours or more and 24 hours or less. There is also a washing method in which the denture is rubbed with a brush and then rinsed. For application to dentures, the liquid composition contained in a container, for example, a container equipped with a thin nozzle, is directly discharged onto the surface of the denture, and then the surface of the denture with a finger, toothbrush, appropriately shaped gauze, sheet agent, etc. A method of spreading and applying the liquid composition so as to cover the surface of the denture while rubbing the surface, after discharging the liquid composition onto a coating substrate such as a finger, a toothbrush, an appropriately shaped gauze, a sheet, etc. There is a method of spreading so that the liquid composition is applied by rubbing on the surface. In particular, a method of spreading the composition while rubbing the denture with a tool such as a toothbrush or a sheet is preferable. In addition, from the viewpoint of stain removability and the preservative power of the denture soaking solution, it is preferable that the composition is applied in an amount sufficient to cover the entire denture.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% means mass% unless otherwise specified. The compounding amount of each component in the table indicates the amount in terms of pure content.

Moreover, the following were used as each component of a raw material.
Polyoxyethylene (POE) lauryl ether (EO average addition mole number 15);
Made by Nippon Emulsion Co., Ltd. (Brand name EMALEX 715)
Polyoxyethylene hydrogenated castor oil (EO average addition mole number 60);
Made by Nikko Chemicals (trade name HCO-60)
Decaglyceryl laurate;
Made by Taiyo Chemical Co., Ltd. (trade name Sunsoft M-12J)
Polyoxyethylene (196) polyoxypropylene (67) glycol;
BASF Japan K.K. (Brand name Lutrol F-127)
Benzethonium chloride; cetylpyridinium chloride manufactured by Wako Pure Chemical Industries, Ltd .; sodium sulfite manufactured by Wako Pure Chemical Industries, Ltd .; Nisso Metal Chemical Co., Ltd. (trade name, purified anhydrous sodium sulfite)
Xanthan gum; manufactured by Kelco (trade name: Monato Gum DA)
Sodium carboxymethylcellulose;
Daicel Chemical Industries, Ltd. (trade name CMC1250)
Hydroxyethylcellulose sodium;
Daicel Chemical Industries, Ltd. (trade name SE850)
Disodium dihydrogen pyrophosphate; sodium tripolyphosphate manufactured by Taihei Chemical Sangyo Co., Ltd .; other optional components manufactured by Taihei Chemical Sangyo Co., Ltd .; all using Japanese Pharmacopoeia, quasi-drug raw materials or food additive standards compliant products.

[Experimental Example 1]
Preparations (liquid compositions for denture cleaning) having the compositions shown in Tables 1 and 2 were prepared by the following manufacturing method, and the following methods were used (shape retention, dispersibility, ease of rubbing), stain removal power, immersion The antiseptic power and appearance stability of the liquid were evaluated. The results are shown in Tables 1 and 2.

(1) Manufacturing method A phase A was prepared by mixing and dissolving water-soluble components such as sodium sulfite, cationic disinfectant, disodium dihydrogen pyrophosphate, sodium tripolyphosphate, and a wetting agent (such as glycerin) in purified water. A pH adjuster was added if necessary.
2. A water-soluble polymer substance (xanthan gum or the like) was added to polyethylene glycol 400 and dispersed by stirring, and then gradually added to phase A, and mixed and stirred sufficiently to dissolve to prepare phase B.
3. A nonionic surfactant (heated and dissolved in water if necessary) was added to phase B to prepare phase C. If necessary, the nonionic surfactant was dissolved by heating.
4). The C phase was stirred under reduced pressure (40 mmHg) to obtain a liquid composition. In the production, a Mizuho vacuum emulsifier was used.

(2) pH measurement method About the blended product transferred to a glass container, a pH meter (manufactured by Toa Denpa Kogyo Co., Ltd., HM-30V) and a pH electrode (manufactured by Toa Denpa Kogyo Co., Ltd., GST-5421C) are used. The value after 3 minutes at ° C. was measured.

(3) Viscosity measurement method The blended product (test liquid composition) was transferred to a glass screw tube bottle (100 mL, Marem No. 8), sealed with a cap, and then left in a 25 ° C. water bath for 30 minutes. Using a BH viscometer (manufactured by Toki Sangyo Co., Ltd.), the viscosity (mPa · s) was calculated from the reading value after 3 minutes at a rotation speed of 20 rpm, and evaluated according to the following criteria. The rotor used was changed according to the viscosity range as shown below.

Rotor No. 3:
The viscosity ranges from 100 to 5,000 mPa · s. 6:
Viscosity ranges from over 5,000 mPa · s to 40,000 mPa · s. 7:
Viscosity in the range of over 40,000 mPa · s to 160,000 mPa · s

(4) Usability (shape retention, dispersibility, ease of rubbing)
<Evaluation method>
Usability was evaluated by a sensory test using 10 expert panelists. Each paneler extrudes 1 g of the test liquid composition filled in the above tube container onto a toothbrush and a sheet, and in each case, evaluates the deformation of the composition after 30 seconds. Judged by criteria.
Next, (b) dispersibility of each composition when the composition taken on the toothbrush and the sheet is spread while being rubbed against the surface of an acrylic resin model complete denture (produced at a dental laboratory), (c ) Ease of rubbing was comprehensively determined according to the following criteria.

The judgment results of 10 people were averaged, and judged according to the following judgment criteria.
(A) Shape retention 4 points: In any case, no deformation was observed.
3 points: In either case, a slight loss of shape was observed, but the quality was not a problem.
2 points: In either case, a level of loss of shape that causes a quality problem was observed.
1 point: In any case, a level of deformation that was a problem in quality was observed.
(B) Dispersibility 4 points: The composition spread very easily throughout the model complete denture.
3 points: The composition spread easily over the entire model denture.
2 points: It was somewhat difficult to spread the composition over the entire model denture.
1 point: It was very difficult to spread the composition over the entire model denture.
(C) Ease of rubbing 4 points: The model complete denture was very easy to scrub.
3 points: The model denture was easy to scrub.
2 points: It was somewhat difficult to scrub the model complete denture.
1 point: It was very difficult to scrub the model complete denture.

<Criteria>
◎: Average point is 3.5 points or more ○: Average point is 3.0 points or more and less than 3.5 points △: Average point is 2.0 points or more and less than 3.0 points ×: Average point is less than 2.0 points

(5) Preservative power test of immersion liquid In order to verify the preservative power during denture immersion of the liquid composition, a denture biofilm model was created by the following method and evaluated in vitro.

<Denture biofilm model creation method>
A 1 × 1 cm polymerized acrylic plate was placed in a 24-well plate, and 0.5 mL of a 0.5% mucin solution and 0.5% albumin solution mixture was placed there and allowed to stand at 37 ° C. for 1 hour. The mucin albumin solution was removed after 1 hour. Next, cells are collected from the pre-cultured bacterial solution of Candida albicans and Streptococcus mutans, dispersed in PBS (turbidity OD = concentration of 1.0 at 660 nm) of 50 μL each, and allowed to stand at 37 ° C. for 2 hours. did. Thereafter, 1.8 mL of tributicase soy broth (TSB) medium was added and cultured at 37 ° C. for 20 hours to prepare a denture biofilm. After 20 hours, the medium was removed from the well, and 1 mL of water was added for washing, and the operation of removing water was repeated twice. This was used as a denture biofilm model for the test.

<Method for evaluating antiseptic power>
After adding 3 g of each test sample (test liquid composition) to the well of the 6-well plate, the surface of the acrylic plate on which the biofilm was adhered was rubbed on the sample for 10 seconds, and the sample was applied on the acrylic plate (N = 3). Thereafter, three acrylic plates coated with the above composition were placed in a 200 mL glass beaker to which 150 mL of tap water had been added in advance so as not to contact, and immersed for 18 hours. On the next day, 40 μL of the soaking solution was collected and diluted 100-fold in a soybean / casein digest (SCDLP) liquid medium supplemented with lecithin / polysorbate. 100 μL of the diluted solution was smeared on an SCDLP agar medium and cultured at 37 ° C. for 4 days, and the number of colonies was counted as the number of remaining bacteria. This test was performed twice, the average value was calculated | required, and the preservative power in denture immersion was evaluated by the following evaluation criteria. Judgment was made according to the following criteria, and the case of ◎ or ○ was judged that the preservative power of the immersion liquid was good.

<Evaluation criteria>
A: The number of remaining bacteria is 0
○: Residual bacteria count is 1-50
Δ: 51 to 300 remaining bacteria
×: Number of remaining bacteria is 301 or more

(6) Stain removal power test In order to verify the removal power of the liquid composition for denture cleaning against stain stains, a tannin stain model was created and evaluated.

<How to create a tannin stain model>
The surface of a white methacrylic resin plate (Acrylite L, manufactured by Mitsubishi Rayon Co., Ltd.) is sandblasted for 10-15 seconds, ultrasonically washed with ion-exchanged water containing detergent, then rinsed thoroughly with water and ionized overnight. Immerse in replacement water. On the next day, the sample was sufficiently dried, the color difference was measured with a color difference meter, and the average value was calculated to be the initial value of the acrylic white board. Albumin solution (albumin 6.0 g / 1,200 mL) → tannin liquid (50 g of Japanese tea, 5 packs of black tea, boil and filter, dissolve 12 g of instant coffee, make up to 1,200 mL) → iron liquid (iron citrate ( III) Ammonium (6.85 g / 1,200 mL) was repeated in the order of the first 5 cycles at 45 ° C. for 20 minutes, and after the 6th cycle, the operation of immersion at 50 ° C. for 10 minutes was repeated. After 30 cycles, the L value was confirmed to be around 22 with a color difference meter (spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.), and this was used as a stain model for the test.

<Method for evaluating stain removal power>
Using a toothbrush, apply approximately 1 g of the test liquid composition on the stain model plate, and place the above three stain model plates on the bottom of a 200 mL glass beaker to which 100 mL of tap water has been added in advance. Soaked (8 hours). On the next day, after removing the model plate, brushing was performed for 1 minute using an electric brush. Then, after rinsing with running water for 1 minute and drying well, L value, a value, and b value were measured using a color difference meter. Each color difference (ΔE1, ΔE2) was calculated from the L value, a value, and b value before and after the treatment, and the stain removal power was calculated according to the equation (1). An average value was calculated from the removal force of each of the three acrylic plates, and judged according to the following criteria. A case of ◎ or ○ was judged as good stain removability.

  Stain removal rate (%) = ((ΔE1−ΔE2) / ΔE1) × 100 (1)

<Criteria>
◎: Removal rate of 50% or more ○: Removal rate of 30% or more and less than 50% △: Removal rate of 10% or more and less than 30% ×: Removal rate of less than 10%

(7) Appearance stability test of composition <Evaluation method>
A laminate tube composed of linear low density polyethylene as the innermost layer was filled with 50 g of each test liquid composition and stored for one month under high temperature (50 ° C.) or low temperature (−5 ° C.) conditions. Each sample after storage (high-temperature storage product and low-temperature storage product) is allowed to stand at room temperature for 1 day, and then the sample is extruded on paper to change its appearance (composition uniformity, liquid separation, turbidity, discoloration, insolubility) Product precipitation) was evaluated. About discoloration, the change degree was evaluated on the basis of the sample preserve | saved for one month at -5 degreeC.

<Evaluation criteria>
A: No change was observed in all the items of uniformity, liquid separation, turbidity, discoloration, and insoluble matter precipitation in the samples stored at high and low temperatures.
○: A high-temperature and / or low-temperature storage sample showed a level that did not cause a quality problem in any of the items of uniformity, liquid separation, turbidity, discoloration, and insoluble matter precipitation.
(Triangle | delta): In the high temperature and / or low temperature preservation | save sample, the change of the level which causes a slight quality problem was recognized by any item of uniformity, liquid separation, turbidity, discoloration, and insoluble matter precipitation.
X: In a sample stored at high temperature and / or low temperature, a change in a level causing a serious problem in quality was observed in any of the items of uniformity, liquid separation, turbidity, discoloration, and insoluble matter precipitation.

  From the results of Tables 1 and 2, the compositions of the present invention (Examples) are good in all of usability (mold retention, dispersibility, rubability), stain removal power, antiseptic power of the immersion liquid and appearance stability. (○ or ◎). On the other hand, the composition (comparative example) that does not satisfy any of the essential requirements of the present invention was inferior to any of the characteristics.

[Experiment 2]
A liquid composition having the composition shown in Table 3 was prepared according to the above method, and 50 g was filled in a laminate tube having an innermost layer similar to the above composed of linear low density polyethylene. The refreshing feeling at the time of denture installation was evaluated by the following method. The physical properties (pH, viscosity), usability (shape retention, dispersibility, rubability), stain removal power, antiseptic power of the immersion liquid and appearance stability of the product immediately after production were evaluated in the same manner as in Experimental Example 1. went. The results are shown in Table 3.

Typical raw materials were the same as those in Experimental Example 1, and the following materials were used otherwise.
Edetate disodium; manufactured by Lion Corporation (trade name: Disorbin NA2)
Protease: Novozymes, Evalase 16L (trade name registered trademark)
l-Menthol; Takasago Fragrance Industry Co., Ltd. Hakka Oil; Toyo Hikaru Industry Co., Ltd. Peppermint Oil; Takasago Fragrance Industry Co., Ltd. Spearmint Oil; Takasago Fragrance Industry Co., Ltd.

(8) Use feeling (fresh feeling) test when denture is mounted <Evaluation method>
About the liquid composition for a test shown in Table 3, it evaluated by the sensory test using ten complete denture wearer panelists. A 200 mL glass beaker in which 150 mL of tap water is added in advance after each paneler discharges an appropriate amount of the test liquid composition filled in the tube container onto the surface of the denture, spreads it with a toothbrush to rub the entire denture. The denture was soaked inside. After standing overnight (10 hours), after brushing with a toothbrush for 1 minute, rinsing with water, the feeling of use (smooth feeling) when the denture was attached was evaluated according to the following criteria. In addition, the thing of the composition shown below was used as a reference | standard product, and it evaluated on the basis of this. The evaluation results of 10 people were averaged and judged according to the following judgment criteria. A case of ◎ or ○ was judged to be good. The results are shown in Table 3.

Composition of the control product;
Blending ingredients Blending amount (%)
Polyoxyethylene (15) lauryl ether 0.5
Benzethonium chloride 0.5
Sodium sulfite 1.2
Xanthan gum 0.6
Sodium carboxymethylcellulose 0.2
Hydroxyethyl cellulose 0.5
Glycerin 15
Sorbit 10
Polyethylene glycol 400 3
Sodium monohydrogen phosphate 0.3
Sodium dihydrogen phosphate 0.2
Fragrance A 0.2
Water balance
Total 100.0
pH 7.5

In addition, the fragrance | flavor A is the following composition (henceforth the same), and does not contain the fragrance | flavor component of (F) components, such as 1-menthol.
Composition of perfume A;
Blending ingredients Blending amount (%)
Anethol 5
Carvone 5
1,8-cineole 1
Mentofuran 2
Camphor 1
Eugenol 1
Menthyl acetate 1
Methyl salicylate 1
Anise oil 2
Cassia oil 2
Winter green oil 1
Eucalyptus oil 1
Clove oil 1
Total ethanol balance 100

<Evaluation criteria>
3 points: A refreshing feeling is considerably better than the control product.
2 points: A refreshing feeling is slightly better than the control product.
1 point: The refreshing feeling is equivalent or weak compared to the control product.

<Criteria>
◎: Refreshing feeling 2.5 points to 3.0 points ○: Refreshing feeling 2.0 points to less than 2.5 points △: Refreshing feeling 1.5 points to less than 2.0 points ×: Refreshing feeling Less than 1.5

  From the results of Table 3, the compositions (Examples) of the present invention (Examples) in which the components (A) to D), and further the components (E) and (F) were blended were used (shape retention, dispersibility, and rubability). ), Stain removal power, antiseptic power of the immersion liquid, and appearance stability, as well as excellent use feeling (smooth feeling) at the time of denture wearing, all being good (◯ or ◎).

Claims (10)

  (A) a nonionic surfactant, (B) a cationic fungicide, (C) a sulfite, and (D) a water-soluble polymer substance, and the component (A) is added in an amount of 0.2 to 3. 0% by mass, 0.1 to 2.0% by mass of the component (B), 0.5 to 4.0% by mass of the component (C), and the mass ratio of (A) / (B) is 0.00. 3-15, the total compounding quantity of (B) and (C) component exists in the range of 0.6-5.0 mass%, and pH in 25 degreeC is 6.0-8.5, It is characterized by the above-mentioned. An application type liquid composition for cleaning dentures.   (A) The nonionic surfactant is a polyoxyethylene alkyl ether having an average addition mole number of ethylene oxide of 10 to 20 moles and an alkyl group having 12 to 16 carbon atoms, and a fatty acid residue having 10 to 16 carbon atoms. Selected from polyglycerol fatty acid monoester having an average polymerization degree of 8 to 12 and polyoxyethylene polyoxypropylene glycol having an average polymerization degree of ethylene oxide of 180 to 220 mol and an average polymerization degree of propylene oxide of 60 to 80 mol. The liquid composition for denture cleaning according to claim 1, wherein the liquid composition is at least one kind.   (D) The denture cleaning liquid composition according to claim 1 or 2, wherein the water-soluble polymer substance is a combination of xanthan gum and a cellulose polymer substance.   (A) 0.5-1.5 mass% of component, (B) component 0.5-1.0 mass%, (C) component 1.0-2.0 mass%, and (A ) / (B) mass ratio is 1.0 to 4.0, the total blending amount of components (B) and (C) is in the range of 1.5 to 3.0 mass%, and pH at 25 ° C. 4. The application-type liquid composition for cleaning dentures according to claim 1, 2, or 3, wherein 7.0 is 8.0.   Furthermore, (E) Water-soluble polyphosphate is contained, The liquid composition for denture cleaning of any one of Claims 1 thru | or 4 characterized by the above-mentioned.   The denture according to any one of claims 1 to 5, further comprising (F) one or more oil-soluble fragrance ingredients selected from menthol, peppermint oil, peppermint oil and spearmint oil. Liquid composition for cleaning.   The denture cleaning liquid composition according to any one of claims 1 to 6, wherein the viscosity at 25 ° C measured using a B-type viscometer is 2,000 to 50,000 mPa · s.   The liquid composition for denture cleaning according to any one of claims 1 to 7, which does not contain a peroxide.   The liquid composition for denture cleaning according to any one of claims 1 to 8, which does not contain an abrasive.   The denture cleaning liquid composition according to any one of claims 1 to 9, wherein the denture is dipped in water and washed after being applied to the denture.