JP2014009201A - Leave-in bactericidal cleanser composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a leave-in bactericidal cleanser composition, which can achieve both pH stability in weakly acid conditions that is low-irritant to the skin and an immediate and sufficient bactericidal effect, has appropriate shape retention of foam, defoams in a suitable time without remaining foam, is easily dried, and has excellent usability.SOLUTION: A leave-in bactericidal cleanser composition contains (A) a quaternary ammonium compound, (B) a nonionic surfactant, (C) at least one kind selected from an amino acid, an amino acid salt, sodium dl-pyrrolidone carboxylate, (D) an alcohol having 1 to 3 carbon atoms, (E) citric acid, and (F) sodium citrate. The content of the (D) component is 20 mass% to 45 mass%, and the total content of the (E) and (F) components is 0.05 mass% to 0.3 mass%. The bactericidal cleanser composition is filled in a foamer container and discharged in a foam state.

Description

  The present invention relates to a bactericidal detergent composition of the type that does not wash away.

  As the type of sterilizing detergent that is not washed away, a gel-like disinfectant and a disinfectant discharged in liquid form are the mainstream. However, the gel-like disinfectant has a problem of feeling of use such as stickiness after use remains due to the thickener added. Further, the disinfectant discharged in the liquid state has a problem in usability such that it is difficult to take a necessary amount and drops from the palm of the hand.

For the problem of usability, it is a foam type that combines a cationic fungicide such as a quaternary ammonium salt fungicide represented by benzalkonium chloride, a nonionic surfactant, and a lower alcohol. Has been proposed (see Patent Document 1). The quaternary ammonium salt bactericides are widely used as bactericides because they have a wide bactericidal spectrum and immediate effect.
However, when the quaternary ammonium salt fungicide and an anionic compound are used in combination, an anion-cation complex is formed, thereby causing a problem that the bactericidal effect is greatly reduced. It is also known that when the quaternary ammonium salt fungicide is used in combination with a nonionic surfactant, the bactericidal effect is inactivated (see Patent Documents 2 and 3). Further, the quaternary ammonium salt fungicide has a higher bactericidal effect as the pH is higher, and the bactericidal effect is not sufficiently exerted in a weakly acidic region where skin irritation is considered to be small. There is also a problem that it is easily affected and the sterilization effect tends to be unstable.
Therefore, the proposed sterilizing detergent composition is not sufficiently satisfactory in sterilizing effect.

  Therefore, it is possible to achieve both the pH stability in mild acidity with little skin irritation and the sufficient bactericidal effect with immediate effect, and further, the foam has an appropriate foam shape retaining property and defoamed in an appropriate time. However, the present situation is that it is strongly desired to provide a sterilizing detergent composition that does not remain, is easy to dry, and has excellent usability and does not wash away.

International Publication No. 2009/074142 JP-A-8-259428 JP-A-3-47245

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, the present invention can achieve both the pH stability in weak acidity with little skin irritation and a sufficient bactericidal effect with an immediate effect, and also has an appropriate foam shape retaining property and disappears in an appropriate time. An object of the present invention is to provide a bactericidal detergent composition of a type that is foamed and does not leave behind, and is easy to dry.

  The non-washing-type germicidal detergent composition of the present invention as a means for solving the above-mentioned problems is (A) at least one quaternary ammonium selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride. A polyoxyethylene alkyl ether having a compound and (B) an alkyl group having 16 to 22 carbon atoms and an average addition mole number of ethylene oxide of 20 to 30 moles; a polyoxyethylene hydrogenated castor oil having an HLB of 9 to 16; At least one nonionic surfactant selected from polyoxyethylene glyceryl monostearate of HLB 9-16 and polyethylene glycol monostearate of HLB 9-16, and (C) an amino acid, an amino acid salt, and dl-pyrrolidone carboxylic acid At least one selected from sodium And (D) an alcohol having 1 to 3 carbon atoms, (E) citric acid, and (F) sodium citrate, and the content of the component (D) is 20% by mass to 45% by mass. Yes, the total content of the component (E) and the component (F) is 0.05% by mass to 0.3% by mass, filled in a former container, and discharged in the form of foam.

  According to the present invention, it is possible to solve the above-mentioned problems in the prior art, achieve the above-mentioned object, and achieve both pH stability in weak acidity with less skin irritation and sufficient bactericidal effect with immediate effect, To provide a sterilizing detergent composition having a suitable foam shape retaining property, defoaming in a suitable time, without foam remaining, and easy to dry, with excellent usability and not washed off. it can.

FIG. 1 is a schematic cross-sectional view showing an example of a former container. FIG. 2 is an enlarged view of a portion surrounded by a circle in FIG.

(Non-washing type bactericidal detergent composition)
The non-washing type sterilizing detergent composition of the present invention (hereinafter sometimes abbreviated as “sterilizing detergent composition”) may be referred to as a quaternary ammonium compound (hereinafter referred to as “component (A)”). ), A nonionic surfactant (hereinafter sometimes referred to as “component (B)”), an amino acid, an amino acid salt, and sodium dl-pyrrolidonecarboxylate (hereinafter referred to as “(C)”) May be referred to as “component”), an alcohol having 1 to 3 carbon atoms (hereinafter sometimes referred to as “(D) component”), and citric acid (hereinafter referred to as “(E) component”). ) And sodium citrate (hereinafter sometimes referred to as “component (F)”), and further contains other components as necessary.
The sterilizing detergent composition is filled in a former container and discharged in the form of foam.

<(A) component>
The quaternary ammonium compound as the component (A) is at least one selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride. These may be used alone or in combination of two or more.

There is no restriction | limiting in particular as content of the said (A) component, Although it can select suitably according to the objective, 0.03 mass%-0.5 mass% are preferable, 0.04 mass%-0.00. 1% by mass is more preferable. When the content of the component (A) is less than 0.03% by mass, appropriate foam shape retention cannot be obtained, and when rubbing into the use site (for example, palm, fingers, and back of hand). If the amount exceeds 0.5% by mass, bubbles may remain after use.
Hereinafter, in the present invention, “hand” means “palm, fingers, and back of hand”.

<(B) component>
The nonionic surfactant as the component (B) is a polyoxyethylene having an alkyl group having 16 to 22 carbon atoms and an average added mole number of ethylene oxide of 20 to 30 mol (in the present invention, “ POE "), alkyl ethers, HLB 9-16 polyoxyethylene hydrogenated castor oil, HLB 9-16 polysoxyethylene glyceryl monostearate, and HLB 9-16 polyethylene glycol monostearate (in the present invention, And may be abbreviated as “PEG”).

  When the HLB value of the polyoxyethylene hydrogenated castor oil, polysoxyethylene glyceryl monostearate, and polyethylene glycol monostearate is less than 9 or more than 16, a suitable foam shape retaining property cannot be obtained and the hand is rubbed. When falling, it may fall off your hands.

<< Polyoxyethylene alkyl ether >>
If the number of carbon atoms in the alkyl group of the polyoxyethylene alkyl ether is less than 16 or more than 22, moderate foam shape retention may not be obtained, and the hand may sag from the hand when rubbed into the hand.
Moreover, when the average addition mole number of ethylene oxide of the polyoxyethylene alkyl ether is less than 20 moles or more than 30 moles, an appropriate foam shape retention property cannot be obtained, and when rubbed into the hand, it drips from the hand. May end up.

The polyoxyethylene alkyl ether is not particularly limited as long as the carbon number of the alkyl group is 16 to 22 and the average added mole number of ethylene oxide is 20 to 30 mol, and is appropriately selected according to the purpose. can do.
Specific examples of the polyoxyethylene alkyl ether include polyoxyethylene (20) cetyl ether, polyoxyethylene (30) cetyl ether, polyoxyethylene (20) stearyl ether, polyoxyethylene (30) stearyl ether, polyoxy Examples include ethylene (20) behenyl ether and polyoxyethylene (30) behenyl ether. These may be used alone or in combination of two or more. In the polyoxyethylene alkyl ether, the numerical value in parentheses represents the average number of moles of ethylene oxide added.
Among these, polyoxyethylene (20) cetyl ether, polyoxyethylene (30) stearyl ether, polyoxyethylene (20) stearyl ether, polyoxyethylene (20) behenyl ether and the like are preferable.

  Commercially available products can be used as the polyoxyethylene alkyl ether, and specific examples thereof include polyoxyethylene (20) cetyl ethers such as EMALEX 120 and NIKKOL BC-20; EMALEX 130 and NIKKOL BC Polyoxyethylene (30) cetyl ether such as -30; polyoxyethylene (20) stearyl ether such as EMALEX 620, NIKKOL BS-20; polyoxyethylene (30) stearyl ether such as EMALEX 630; EMALEX BHA-20, NIKKOL Polyoxyethylene (20) behenyl ether such as BB-20; polyoxyethylene (30) behenyl ether such as EMALEX BHA-30 and NIKKOL BB-30 (the trade name: EMALE Examples of X include Nihon Emulsion Co., Ltd., and trade name: NIKKOL, manufactured by Nikko Chemicals Co., Ltd.).

<< Polyoxyethylene hydrogenated castor oil >>
There is no restriction | limiting in particular as said polyoxyethylene hydrogenated castor oil of HLB9-16, According to the objective, it can select suitably, For example, a polyoxyethylene (20) hardened castor oil (henceforth "POE (20) hardened"). Castor oil ”(HLB9), polyoxyethylene (30) hydrogenated castor oil (hereinafter sometimes referred to as“ POE (30) hydrogenated castor oil ”) (HLB11), polyoxyethylene (40) Hardened castor oil (hereinafter sometimes referred to as “POE (40) hardened castor oil”) (HLB12), polyoxyethylene (50) hardened castor oil (hereinafter referred to as “POE (50) hardened castor oil”) (HLB13), polyoxyethylene (60) hydrogenated castor oil (hereinafter sometimes referred to as “POE (60) hydrogenated castor oil”) (H B14), polyoxyethylene (80) hydrogenated castor oil (hereinafter sometimes referred to as “POE (80) hydrogenated castor oil”) (HLB15), polyoxyethylene (100) hydrogenated castor oil (hereinafter “POE (100)”). ) Hardened castor oil ”(sometimes referred to as“ HLB 15) ”. These may be used alone or in combination of two or more. In addition, in the said polyoxyethylene hydrogenated castor oil, the numerical value in a parenthesis represents the average addition mole number of ethylene oxide.
Among these, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, polyoxyethylene (100) Hardened castor oil is preferred.

  As the polyoxyethylene hydrogenated castor oil, a commercially available product can be used. Specific examples thereof include, under the trade name, polyoxyethylene (20) hydrogenated castor oil such as EMALEX HC-20; EMALEX HC-30 and the like. Polyoxyethylene (30) hydrogenated castor oil; polyoxyethylene (40) hydrogenated castor oil such as EMALEX HC-40; polyoxyethylene (50) hydrogenated castor oil such as EMALEX HC-50; polyoxygen such as EMALEX HC-60 Ethylene (60) hydrogenated castor oil; polyoxyethylene (80) hydrogenated castor oil such as EMALEX HC-80; polyoxyethylene (100) hydrogenated castor oil (such as Emulex HC-100) Can be mentioned.

<< Polyoxyethylene glycerol monostearate >>
The HLB 9 to 16 monostearate polyoxyethylene glycerin is not particularly limited and may be appropriately selected depending on the intended purpose. For example, monostearate polyoxyethylene glycerin (5) (hereinafter referred to as “PEG stearate”). -5 glyceryl ”(HLB9), polyoxyethylene glyceryl monostearate (10) (hereinafter sometimes referred to as“ PEG-10 glyceryl stearate ”) (HLB11), polyoxymonostearate Ethylene glycerin (15) (hereinafter sometimes referred to as “PEG-15 glyceryl stearate”) (HLB13), polyoxyethylene glycerol monostearate (20) (hereinafter referred to as “PEG-20 glyceryl stearate”) There is (HLB14), Polyoxyethylene glyceryl stearate (30) (hereinafter sometimes referred to as “PEG-30 glyceryl stearate”) (HLB15), polyoxyethylene glyceryl monostearate (40) (hereinafter referred to as “PEG-40 glyceryl stearate”) ”(HLB16). These may be used alone or in combination of two or more. In the polyoxyethylene glyceryl monostearate, the numerical value in parentheses represents the average added mole number of ethylene oxide.
Among these, monostearate polyoxyethylene glycerol (15), monostearate polyoxyethylene glycerol (20), monostearate polyoxyethylene glycerol (30), and monostearate polyoxyethylene glycerol (40) are preferable.

  As the monostearate polyoxyethylene glycerin, a commercially available product can be used. Specific examples thereof are trade names; monooxystearate polyoxyethylene glycerin (5) such as EMALEX GM-5; EMALEX GM- Monostearic acid polyoxyethylene glycerol (10) such as 10; EMALEX GM-15 monostearic acid polyoxyethylene glycerol (15); Monostearic acid polyoxyethylene glycerol (20) such as EMALEX GM-20; EMALEX GM- 30 monooxystearate polyoxyethylene glycerol (30) such as 30; monostearate polyoxyethylene glycerol (40) such as EMALEX GM-40 (above, Nippon Emulsion Co., Ltd.) and the like.

<< Polyethylene glycol monostearate >>
The HLB 9-16 polyethylene glycol monostearate is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include polyethylene glycol monostearate (10) (hereinafter referred to as “PEG-10 stearate”). (HLB11), polyethylene glycol monostearate (20) (hereinafter sometimes referred to as “PEG-20 stearate”) (HLB14), polyethylene glycol monostearate (30) (hereinafter referred to as “stearate”). Acid PEG-30 ”(sometimes referred to as“ acid PEG-30 ”) and polyethylene glycol monostearate (40) (hereinafter sometimes referred to as“ PEG-40 stearate ”) (HLB16). These may be used alone or in combination of two or more. In the polyethylene glycol monostearate, the numerical value in parentheses represents the average number of moles of ethylene oxide added.
Among these, polyethylene glycol monostearate (20), polyethylene glycol monostearate (30), and polyethylene glycol monostearate (40) are preferable.

  As the polyethylene glycol monostearate, a commercially available product can be used. Specific examples thereof include, under the trade names, polyethylene glycol monostearate (10) such as EMALEX 810; polyethylene glycol monostearate (20) such as EMALEX 820. And polyethylene glycol monostearate (30) such as EMALEX 830; polyethylene glycol monostearate (40) such as EMALEX 840 (manufactured by Nippon Emulsion Co., Ltd.).

  Among these, as said (B) component, the carbon number of an alkyl group is 16-22, and the polyoxyethylene (POE) alkyl ether whose average added mole number of ethylene oxide is 20 mol-30 mol is preferable, Polyoxyethylene (20) stearyl ether, polyoxyethylene (30) stearyl ether, polyoxyethylene (20) cetyl ether, polyoxyethylene (20) behenyl ether are particularly suitable in that moderate foam shape retention can be obtained. preferable.

In the present invention, the HLB value is indicated by IOB × 10 in the organic conceptual diagram. The IOB in the organic conceptual diagram refers to the ratio of the inorganic value (IV) to the organic value (OV) in the organic conceptual diagram, that is, “inorganic value (IV) / organic value (OV)”.
The organic conceptual diagram was proposed by Satoshi Fujita, and details thereof are described in “Pharmaceutical Bulletin”, 1954, vol. 2, 2, pp. 163-173; "Area of Chemistry", 1957, vol. 11, 10, pp. 719-725; "Fragrance Journal", 1981, vol. 50, pp. 79-82. That is, the source of all organic compounds is methane (CH ₄ ), all other compounds are all regarded as derivatives of methane, and certain numbers are set for the carbon number, substituent, transformation part, ring, etc. Add scores to determine organic and inorganic values. This value is plotted on a diagram with the organic value on the X axis and the inorganic value on the Y axis. This organic conceptual diagram is also shown in “Organic conceptual diagram-basics and application” (by Yoshio Koda, Sankyo Publishing, 1984).

  There is no restriction | limiting in particular as content of the said (B) component, Although it can select suitably according to the objective, 0.03 mass%-0.5 mass% are preferable, 0.07 mass%-0.00. 2 mass% is more preferable. When the content of the component (B) is less than 0.03% by mass, an appropriate foam shape retention property cannot be obtained, and when rubbed into the hand, it may sag from the hand. If it exceeds 5 mass%, bubbles may remain after rubbing hands, and the bactericidal effect may be reduced.

<(C) component>
The component (C) is at least one selected from amino acids, amino acid salts, and sodium dl-pyrrolidonecarboxylate.

  There is no restriction | limiting in particular as a kind of said amino acid, According to the objective, it can select suitably, For example, glycine, lysine, serine, proline, arginine, glutamic acid etc. are mentioned. These may be used alone or in combination of two or more.

The amino acid salt is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include alkali metal salts and alkaline earth metal salts of the amino acids. These may be used alone or in combination of two or more.
Specific examples of the amino acid salt include sodium glutamate.

  Among these, as the component (C), sodium dl-pyrrolidonecarboxylate, lysine, serine, and glycine are preferable in that appropriate foam shape retention can be obtained, and sodium dl-pyrrolidonecarboxylate is particularly preferable.

  There is no restriction | limiting in particular as content of the said (C) component, Although it can select suitably according to the objective, 0.01 mass%-5 mass% are preferable, 0.05 mass%-1 mass% are preferable. More preferred. When the content of the component (C) is less than 0.01% by mass, a suitable foam shape retention property cannot be obtained, and the foam does not disappear in an appropriate time during use, and the foam remains after use. When the amount exceeds 5% by mass, an appropriate foam shape retention property cannot be obtained, and it may sag from the hand, which is not preferable in terms of usability.

<(D) component>
The component (D) is an alcohol having 1 to 3 carbon atoms. Specific examples of the component (D) include methyl alcohol, ethyl alcohol, isopropyl alcohol and the like. These may be used alone or in combination of two or more. Among these, the component (D) is preferably ethyl alcohol in terms of odor during use.

  There is no restriction | limiting in particular as long as it is 20 mass%-45 mass% as content of the said (D) component, Although it can select suitably according to the objective, 35 mass%-40 mass% are preferable. When the content of the component (D) is less than 20% by mass, the quick drying property and the bactericidal effect are deteriorated, the shape retaining property of the foam is not obtained, and the foam does not disappear in an appropriate time during use. If foam exceeds 45% by mass, it will not be foamed even if discharged from the former container, and it will be difficult to pick up or drop from the hand. There is.

<(E) component>
The content of citric acid as the component (E) is not particularly limited as long as the total content with the following component (F) is satisfied, and can be appropriately selected according to the purpose.

<(F) component>
The content of sodium citrate as the component (F) is not particularly limited as long as the total content with the following component (E) is satisfied, and can be appropriately selected according to the purpose.

  The total content of the component (E) and the component (F) is not particularly limited as long as it is 0.05% by mass to 0.3% by mass, and can be appropriately selected according to the purpose. 0.1 mass% to 0.25 mass% is preferable. If the total content of the component (E) and the component (F) is less than 0.05% by mass, the buffering action may be inferior and the pH stability may be deteriorated. The detergent composition may move to the acidic side and the bactericidal effect may be reduced. When the total content of the component (E) and the component (F) exceeds 0.3% by mass, the component (A), the component (E) and / or the component (F) A complex of an anion and a cation is formed, whereby the bactericidal effect is greatly inhibited, and the bactericidal effect may be lowered.

There is no restriction | limiting in particular as mass ratio (F) / (E) of the said (E) component and the said (F) component, Although it can select suitably according to the objective, 1-5 are preferable, 2 4 is more preferable. If the mass ratio (F) / (E) is less than 1, the bactericidal effect may be reduced, or the buffering action may be insufficient. If the mass ratio exceeds 5, the buffering action may be insufficient. There is.
On the other hand, when the mass ratio (F) / (E) is in the more preferable range, the pH at 25 ° C. is maintained at 5 to 6.5, and the buffering by the (E) component and the (F) component is performed. This is advantageous not only because the action is good, but also because the bactericidal effect does not decrease.

<Other ingredients>
The other components are not particularly limited as long as the effects of the present invention are not impaired, and can be appropriately selected depending on the purpose. For example, water, a solvent such as a polyhydric alcohol; the component (A) and the component Disinfectant other than component (D); water-soluble polymer compound; anti-inflammatory agent such as dipotassium glycyrrhizinate; fragrance; cooling agent; cooling agent; coloring agent; oil; silicones; Metal sequestering agents; animal and plant extracts or derivatives thereof; inorganic powders; clay minerals; water-insoluble polymer powders such as nylon and polyethylene. These may be used alone or in combination of two or more.

<< Polyhydric alcohol >>
There is no restriction | limiting in particular as said polyhydric alcohol, Although it can select suitably according to the objective, Propylene glycol (PG), 1, 3- butylene glycol (BG), glycerin etc. which can anticipate the rough skin prevention effect etc. Is preferred.
There is no restriction | limiting in particular as content of the said polyhydric alcohol, Although it can select suitably according to the objective, 5 mass% or less is preferable. If the content of the polyhydric alcohol exceeds 5% by mass, the skin may become sticky after use.

<< Fungicide >>
The bactericide other than the component (A) and the component (D) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, isopropylmethylphenol, triclosan, trichlorocarbarinide, chlorhexidine hydrochloride, alkyl Examples include diaminoethyl glycine and octopirox. These may be used alone or in combination of two or more.

<< Water-soluble polymer compound >>
The water-soluble polymer compound is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include anionic polymer compounds such as alkyl acrylate copolymers; cationized cellulose, dimethyldiallylammonium chloride, Cationic polymer compounds such as acrylamide copolymer and cation-modified guar gum; Nonionic polymer compounds such as hydroxypropyl methylcellulose and vinyl acetate / vinyl pyrrolidone copolymer; dimethylallyl quaternary salt / acrylamide vinyl pyrrolidone acrylate N / N -Amphoteric polymers such as dimethylaminoethyl. These may be used alone or in combination of two or more.

<< fragrance >>
There is no restriction | limiting in particular as said fragrance | flavor, According to the objective, it can select suitably from well-known fragrance | flavors. Examples of the fragrance include “Perfume and Flavor Chemicals”, Vol. I and II, Stephen Arctander, Allured Pub. Co. 1994, “Synthetic perfume chemistry and product knowledge”, Motoichi Into, Chemical Industry Daily, 1996; “Perfume and Flavor Materials of Natural Origin”, Stephen Arctander, Allred Pub. Co. , 1994; “Encyclopedia of Scents”, edited by Japan Fragrance Association, Asakura Shoten, 1989; “Perfume Material Material Performance V.3.3”, Boelens Aroma Chemical Information, 1996, “Flower Information Service, 1996”. Anonis, Allured Pub. Co. , 1993 and the like. Specific examples of the perfume include eucalyptus oil, camphor, borneol, lemon oil, lime oil, grapefruit extract, lavender oil, lavender extract, rosemary oil, rosemary extract and the like. These may be used alone or in combination of two or more.

  The fragrance may be a mixture of the fragrance component, a fragrance solvent, and a fragrance stabilizer.

The perfume solvent is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include benzyl benzoate, acetin (triacetin), MMB acetate (3-methoxy-3-methylbutyl acetate), ethylene glycol dibuty Rate, hexylene glycol, dibutyl sebacate, deltile extra (isopropyl myristate), methyl carbitol (diethylene glycol monomethyl ether), carbitol (diethylene glycol monoethyl ether), TEG (triethylene glycol), benzyl benzoate, phthalic acid Diethyl, tripropylene glycol, aborin (dimethyl phthalate), deltyl prime (isopropyl palmitate), dipropylene glycol DPG-FC (dipropylene glycol) ), Farnesene, dioctyl adipate, tributyrin (glyceryl tributanoate), hydrolite-5 (1,2-pentanediol), propylene glycol diacetate, cetyl acetate (hexadecyl acetate), ethyl abiate, avaline (methyl abiate) ), Citroflex A-2 (acetyltriethyl citrate), Citroflex A-4 (tributylacetyl citrate), Citroflex No. 2 (triethyl citrate), Citroflex No. 4 (tributyl citrate), Durafix (methyl dihydroabietate), MITD (isotridecyl myristate), polylimonene (limonene polymer), 1,3-butylene glycol and the like. These may be used alone or in combination of two or more.
There is no restriction | limiting in particular as content of the said solvent for fragrance | flavors, Although it can select suitably according to the objective, 0.1 mass%-99 mass% are preferable in the said fragrance | flavor composition, 0.1 mass% 10 mass% is more preferable.

The perfume stabilizer is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include dibutylhydroxytoluene, butylhydroxyanisole, vitamin E or derivatives thereof, catechin compounds, flavonoid compounds, polyphenol compounds, and the like. Can be mentioned. These may be used alone or in combination of two or more. Among these, dibutylhydroxytoluene is preferable.
There is no restriction | limiting in particular as content of the said fragrance | flavor stabilizer, Although it can select suitably according to the objective, 0.0001 mass%-10 mass% are preferable in the said fragrance | flavor composition, 0.001 mass % To 5% by mass is more preferable.

  There is no restriction | limiting in particular as content of the said fragrance | flavor composition, Although it can select suitably according to the objective, 0.005 mass%-40 mass% are preferable, and 0.01 mass%-10 mass% are more. preferable.

<< Coolant >>
There is no restriction | limiting in particular as said refreshing agent, According to the objective, it can select suitably, For example, menthol, peppermint oil, mint oil etc. are mentioned. These may be used alone or in combination of two or more.

<< Coolant >>
The cooling agent is not particularly limited and may be appropriately selected depending on the intended purpose. For example, N-ethyl-p-menthane-3-carboxamide (for example, trade name: WS3, manufactured by Takasago International Corporation) 1-menthyl glyceryl ether (for example, trade name: CA-10, manufactured by Takasago International Corporation).

<Former container>
The sterilizing detergent composition is filled in a former container (foam discharge container) and discharged in the form of foam. Therefore, the sterilizing detergent composition can be suitably used as a sterilizing detergent composition for former containers.

There is no restriction | limiting in particular as said former container, Although it can select suitably according to the objective, A non-gas type | mold former container is preferable. The non-gas type former container is not particularly limited as long as it can mix the sterilizing detergent composition with air and discharge it in a foamed state, and can be appropriately selected according to the purpose. Examples include a squeeze foamer container that can discharge foam by manually squeezing the body part; a pump foamer container that can discharge foam by depressing the nozzle part.
As such a former container, for example, those manufactured by Daiwa Steel Co., Ltd., Yoshino Kogyo Co., Ltd., etc. can be used. More specifically, the former containers described in JP-A-7-315463, JP-A-8-230961, JP-A-2005-193972, and the like can be used.

The non-gas type former container usually has a porous film body for forming bubbles, and bubbles are formed by passing the sterilizing detergent composition through the porous film body.
There is no restriction | limiting in particular as a material of the said porous membrane body, Although it can select suitably according to the objective, Plastic materials, such as nylon, polyester, polyolefin, are preferable.
There is no restriction | limiting in particular as an opening of the said porous membrane body, Although it can select suitably according to the objective, 110 meshes (161 micrometers) or more are preferable, and 110 meshes-380 meshes (161 micrometers-32 micrometers) are more preferable. 200 mesh to 355 mesh (77 μm to 37 μm) is particularly preferable.
Moreover, there is no restriction | limiting in particular as the number of the said porous membrane body, Although it can select suitably according to the objective, From a viewpoint of improving foam performance, 2-4 sheets are preferable.

  The property of the sterilizing detergent composition is preferably liquid at normal temperature (20 ± 15 ° C.). The viscosity of the sterilizing detergent composition is, for example, that the nozzle part is pushed down as the former container. When using two pump foam containers that can discharge bubbles and a porous membrane with an opening of 305 mesh (48 μm), or two porous with an opening of 200 mesh (77 μm) and an opening of 305 mesh (48 μm) Viscosity when measured using a BL type viscometer (manufactured by Tokyo Keiki Co., Ltd.) under the conditions of rotor No. 1, 60 rpm, and 30 seconds under the temperature conditions used (usually 25 ° C.). However, it is preferably 30 mPa · s or less, more preferably 20 mPa · s or less, and particularly preferably 10 mPa · s. When the viscosity exceeds 30 mPa · s, the sterilizing detergent composition may be clogged in the porous film body, cannot be discharged, and a suitable foam shape retention property may not be obtained.

<< Manufacturing method of sterilizing detergent composition >>
There is no restriction | limiting in particular as a manufacturing method of the said disinfection detergent composition, According to the objective, it can select suitably.
The sterilizing detergent composition may be prepared using an apparatus. There is no restriction | limiting in particular as said apparatus, Although it can select suitably according to the objective, The stirring apparatus provided with the several stirring blade (propeller, turbine, disper, etc.) which can be mixed with a shear force and the whole is preferable.
When producing the sterilizing detergent composition, the component (A), the component (B), the component (C), the component (D), the component (E), and the component (F) are necessary. Accordingly, the mixing order of the other components is not particularly limited and may be appropriately selected depending on the purpose. Moreover, each component may be mix | blended independently sequentially, and after preparing the mixture containing 2 or more types of components, you may prepare a disinfection detergent composition.

<Application>
The use of the sterilizing detergent composition is not particularly limited and may be appropriately selected depending on the purpose. For example, the sterilizing detergent composition is suitable as a sterilizing detergent composition for hands (palms, fingers, and backs of hands). Is available. The sterilizing detergent composition can also be used for body use such as body use. The application site includes, for example, a hospital, a nursing facility, a kitchen use, and the like, and is also preferably used at home.
Moreover, the said sterilizing detergent composition is suitably used for a former container. When the said sterilizing detergent composition is used for a former container, it may be referred to as a sterilizing detergent composition for a former container.

EXAMPLES The present invention will be specifically described below with reference to examples of the present invention, but the present invention is not limited to these examples.
In the following examples and comparative examples, “%” represents “% by mass”. Moreover, all the compounding quantities of each component of Tables 1-6 are conversion of a pure part. Moreover, in Tables 1-6, the numerical value in the parenthesis of (B) component and the numerical value described after PEG represent the average addition mole number of ethylene oxide.

(Examples 1-37, Comparative Examples 1-10)
The sterilizing detergent compositions of Examples 1 to 37 and Comparative Examples 1 to 10 having the compositions and blending amounts shown in Tables 1 to 6 were prepared according to a conventional method. Subsequently, each sterilizing detergent composition was filled in a former container (manufactured by Yoshino Kogyo Co., Ltd.) having the specifications described in JP-A-2005-193972. Specifically, the former container is a former container 1 as shown in FIG. 1 and FIG. 2, the volume ratio of gas to liquid (gas / liquid) is 13/1, and the discharge amount per push is 1 g, and the foam forming member used two sheets of a 200-mesh (77 μm) porous film body 3 and a 305-mesh (48 μm) porous film body 2.
Using the sterilizing detergent compositions of Examples 1 to 37 and Comparative Examples 1 to 10 filled in the former container, “moderate foam shape retention”, “no foam residue”, “Ease of drying”, “stability”, and “bactericidal effect” were evaluated.

<Evaluation of moderate foam shape retention>
Under the conditions of a temperature of 25 ° C. and a relative humidity of 60%, 1 g of the sterilizing detergent composition was discharged from the former container onto the polyvinylidene chloride film, and the height of the foam on the polyvinylidene chloride film after 30 seconds was measured. . The height of the bubble means the height (maximum height) of the highest position of the bubble from the surface of the polyvinylidene chloride film. In addition, when performing the said discharge, it is made to discharge from the direction perpendicular | vertical with respect to the surface of this polyvinylidene chloride film, and the distance (height) between the discharge port of the said former container and the surface of a polyvinylidene chloride film is 5 cm. did. The same operation was performed 3 times, and the following evaluation criteria were evaluated based on the average value of 3 times. The results are shown in Tables 1-6.
[Evaluation criteria]
◎: Bubble height after 30 seconds is 16 mm or more and less than 20 mm ○: Bubble height after 30 seconds is 13 mm or more and less than 16 mm Δ: Bubble height after 30 seconds is 5 mm or more and less than 13 mm ×: The height of the foam after 30 seconds is less than 5 mm or more than 20 mm. Note that the foam with a height of less than 5 mm after 30 seconds (x) has poor shape retention of the foam, and the hand (palm, hand finger) , And the back of the hand), it is easy to sag and it becomes a problem in usability. In addition, even when the bubble height after 30 seconds is 20 mm or more (×), bubbles taken on the hand (palm, finger of the hand, and back of the hand) do not disappear in a reasonable time, and the hand (palm, finger of the hand) , And the back of the hand), it becomes difficult to rub and becomes a problem in terms of usability. Therefore, the suitable foam shape-retaining property that is preferable for use as a sterilizing detergent composition is one that is ◯ or ◎ according to the above evaluation criteria.

<Nothing left after foam>
Under the conditions of a temperature of 25 ° C. and a relative humidity of 60%, 1 g of the sterilizing detergent composition is discharged from the former container onto the palm of 10 professional panelists, and the hand (palm, fingers, and back of the hand) is held for about 10 seconds. After rubbing, the remaining foam in the hand (palm, fingers, and back of hand) was determined according to the following criteria. An average value of 10 professional panelists was calculated, and the following evaluation criteria were evaluated based on the average value. The results are shown in Tables 1-6.
[Criteria]
5 points: no bubble residue 4 points: almost no bubble residue 3 points: some bubble residue 2 points: considerable bubble residue 1 point: Bubbles increase [Evaluation Criteria]
◎: Average value is 4.0 points or more ○: Average value is 3.0 points or more and less than 4.0 points △: Average value is 2.0 points or more and less than 3.0 points ×: Average value is , Less than 2.0 points.

<Evaluation of ease of drying>
Under conditions of a temperature of 25 ° C. and a relative humidity of 60%, 1 g of the sterilizing detergent composition is discharged from the former container onto the palm of 10 professional panelists, and rubbed in the hand (palm, palm of the hand, and back of the hand) The time until the sterilizing detergent composition was dried was measured. The average value of 10 expert panelists until drying was calculated, and based on this average value, the following evaluation criteria were used. The results are shown in Tables 1-6.
[Evaluation criteria]
A: The average time until the sterilizing detergent composition dries is less than 30 seconds. A: The average time until the sterilizing detergent composition dries is 30 seconds or more and less than 60 seconds. Δ: The average time until the sterilizing detergent composition dries. Is not less than 60 seconds and less than 90 seconds. X: The average time until the sterilizing detergent composition is dried is not less than 90 seconds.

<Evaluation of stability>
Immediately after the manufacture of the sterilizing detergent composition, the composition is filled into a 50 mL glass bottle, and the pH under the conditions of an initial temperature of 25 ° C. and a relative humidity of 60% (hereinafter sometimes referred to as “the initial pH of manufacture”). Was measured, and then stored in a thermostatic bath at a temperature of 60 ° C. for 2 weeks. After storage for 2 weeks, the pH of the composition after storage for 2 weeks (hereinafter sometimes referred to as “time-dependent pH”) was measured again under the conditions of a temperature of 25 ° C. and a relative humidity of 60%. The difference between the production initial pH and the time-dependent pH was calculated, and the pH change rate was further calculated by the following formula 1 or formula 2. Based on this rate of change in pH, the following evaluation criteria were used. The results are shown in Tables 1-6.
When time-dependent pH ≧ production initial pH,
pH change rate (%) = (time-dependent pH−initial production pH) / initial production pH × 100 (Equation 1)
When time-dependent pH <production initial pH,
pH change rate (%) = (initial pH of production−pH with time) / initial pH of production × 100 (Equation 2)
[Evaluation criteria]
：: pH change rate is less than 1% ○: pH change rate is 1% or more and less than 2% ×: pH change rate is 2% or more Note that ◯ and ◎ are within the allowable range.

<Evaluation of bactericidal effect>
E. coli ( Escherichia coli NBRC 3972; obtained from the National Institute of Technology and Evaluation Technology) was used as the target bacterium, and the bactericidal effect of each bactericidal detergent composition was evaluated by the following quantitative suspension method.
The target bacteria were cultured at 37 ° C. for 18 hours using an SCD agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). An appropriate amount of colonies formed on the SCD agar medium was scraped and suspended in physiological saline, adjusted to a bacterial concentration of 10 ⁸ cfu / mL, and used as a test bacterial solution. In addition, cfu means a colony forming unit (Colony forming unit).
After ingesting 0.05 mL of the test microbial solution into 4.95 mL of each bactericidal detergent composition and exposing it for 30 seconds with stirring, the mixture was immediately increased 10 times with SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.). Diluted and inactivated. This inactivated liquid is referred to as “inactivated liquid (A)”. The inactivation liquid (A) is further diluted with SCDL liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.) 100 times (hereinafter sometimes referred to as “inactivation liquid (B)”), 1,000 times (hereinafter referred to as “inactivation liquid (B)”). "Inactivation liquid (C)"), and 10,000-fold dilution (hereinafter also referred to as "inactivation liquid (D)") and 10-fold serial dilution to inactivate them. 1 mL of each of the liquids (A) to (D) was taken in a petri dish having a diameter of 9 cm, and cultured on a SCDLP agar medium (manufactured by Nippon Pharmaceutical) at 37 ° C. for 24 hours. After culturing, all formed colonies were counted and the number of remaining viable bacteria was measured. When no colony was observed, the detection limit was set to less than 10. The number of remaining viable bacteria was determined according to the following criteria. The above test was performed three times, the average value of the following criteria was calculated, and the following evaluation criteria were evaluated based on this average value. The results are shown in Tables 1-6.
[Criteria]
5 points: The number of remaining viable bacteria is the detection limit (bactericidal rate is greater than about 99.999%)
4 points: the number of remaining viable bacteria is less than 100 cfu / mL (bactericidal rate greater than about 99.99% and less than 99.999%)
3 points: The number of remaining viable bacteria is 100 cfu / mL or more and less than 1,000 cfu / mL (bactericidal rate is larger than about 99.9% and 99.99% or less)
2 points: Residual viable count of 1,000 cfu / mL or more and less than 10,000 cfu / mL (bactericidal rate greater than about 99% and 99.9% or less)
1 point: The number of remaining viable bacteria is 10,000 cfu / mL or more (bactericidal rate is about 99% or less)
[Evaluation criteria]
◎: Average value is 4.0 points or more ○: Average value is 3.0 points or more and less than 4.0 points △: Average value is 2.0 points or more and less than 3.0 points ×: Average value is Less than 2.0

The raw materials used in the examples and comparative examples are as follows.
<(A) component>
Benzalkonium chloride: trade name “Nissan Cation F2-50E”, manufactured by NOF Corporation, indication formula: C ₆ H ₅ CH ₂ N ⁺ (CH ₃ ) ₂ R · Cl ⁻ , in the above-described formula R Represents an alkyl chain length, and R = C12 / C14 = 63/37 (mass ratio).
・ Cetylpyridinium chloride: Trade name “Cetylpyridinium chloride”, manufactured by Wako Pure Chemical Industries, Ltd. ・ Benzethonium chloride: Trade name “Hiamine Crystal”, manufactured by Mitsubishi Chemical Foods Co., Ltd. (component (B))
-POE (60) hydrogenated castor oil (polyoxyethylene (60) hydrogenated castor oil): Trade name "EMALEX HC-60", HLB14, average added mole number of ethylene oxide 60, manufactured by Nippon Emulsion Co., Ltd.-POE (80) Hardened castor oil (polyoxyethylene (80) hardened castor oil): Trade name “EMALEX HC-80”, HLB15, average added mole number of ethylene oxide 80, polyoxyethylene (20) stearyl ether manufactured by Nippon Emulsion Co., Ltd .: Trade name “NIKKOL BS-20”, average addition mole number of ethylene oxide 20; manufactured by Nikko Chemicals, polyoxyethylene (30) stearyl ether: trade name “EMALEX 630”, average addition mole number of ethylene oxide 30, Japan Emulsion Co., poly Oxyethylene (20) cetyl ether: trade name “NIKKOL BC-20”, average added mole number of ethylene oxide 20, polyoxyethylene behenyl ether (20) manufactured by Nikko Chemicals Co., Ltd .: trade name “NIKKOL BB-20”, Average addition mole number of ethylene oxide 20, Nikko Chemicals Co., Ltd., PEG-40 stearate (polyethylene glycol monostearate): Trade name “EMALEX 840”, HLB16, average addition mole number of ethylene oxide 40, manufactured by Nippon Emulsion Co., Ltd. PEG-40 glyceryl stearate (polyoxyethylene glyceryl monostearate): trade name “EMALEX GM-40”, HLB16, average added mole number of ethylene oxide 40, manufactured by Nippon Emulsion Co., Ltd. <(C) Minute>
-Sodium dl-pyrrolidonecarboxylate: trade name "PCA Soda", manufactured by Ajinomoto Co., Inc.-Lysine: trade name "L-lysine hydrochloride", manufactured by Ajinomoto Co., Inc.-Serine: trade name "L-serine", Kyowa Hakko Kogyo Co., Ltd. Made by company <(D) ingredient>
・ Ethyl alcohol: Trade name “95% general ethanol”, manufactured by Konishi Co., Ltd. ・ Isopropyl alcohol: Trade name “Isopropanol”, manufactured by Gansu Chemical Industry Co., Ltd.
・ Citric acid: trade name “Japanese Pharmacopoeia Citric Acid Hydrate”, Komatsuya Co., Ltd. (component (F))
・ Sodium citrate: Trade name “Japanese Pharmacopoeia Sodium Citrate Hydrate”, Komatsuya Co., Ltd. <Common ingredients>
・ Menthol: Trade name “l-menthol”, manufactured by Takasago International Corporation ・ Eucali oil: Trade name “Japan Pharmacopoeia Eucalyptus Oil”, manufactured by Nippon Terpene Chemical Co., Ltd. ・ Dye: Trade name “Yellow No. 4”, Daiwa Kasei Made by Co., Ltd.

Examples of the aspect of the present invention include the following.
<1> (A) at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride;
(B) polyoxyethylene alkyl ether having an alkyl group having 16 to 22 carbon atoms and an average addition mole number of ethylene oxide of 20 to 30 mol, polyoxyethylene hydrogenated castor oil having HLB 9 to 16, and HLB 9 to 16 At least one nonionic surfactant selected from polyoxyethylene glyceryl monostearate and polyethylene glycol monostearate of HLB 9-16,
(C) at least one selected from amino acids, amino acid salts, and sodium dl-pyrrolidonecarboxylate;
(D) an alcohol having 1 to 3 carbon atoms;
(E) citric acid,
(F) sodium citrate;
The content of the component (D) is 20% by mass to 45% by mass, and the total content of the component (E) and the component (F) is 0.05% by mass to 0.3% by mass. This is a non-washing-type sterilizing detergent composition characterized by being filled in a former container and discharged in the form of foam.
<2> The antibacterial detergent composition according to <1>, wherein the mass ratio (F) / (E) of the component (F) to the component (E) is 2 to 4.
<3> The antibacterial detergent composition according to any one of <1> to <2>, which is for a former container.

  The use of the sterilizing detergent composition is not particularly limited and may be appropriately selected depending on the purpose. For example, the sterilizing detergent composition is suitable as a sterilizing detergent composition for hands (palms, fingers, and backs of hands). Is available. The sterilizing detergent composition can also be used for body use such as body use. The application site includes, for example, a hospital, a nursing facility, a kitchen use, and the like, and is also preferably used at home.

1 Former container 2, 3 Porous membrane body

Claims (2)

(A) at least one quaternary ammonium compound selected from benzalkonium chloride, cetylpyridinium chloride, and benzethonium chloride;
(B) polyoxyethylene alkyl ether having an alkyl group having 16 to 22 carbon atoms and an average addition mole number of ethylene oxide of 20 to 30 mol, polyoxyethylene hydrogenated castor oil having HLB 9 to 16, and HLB 9 to 16 At least one nonionic surfactant selected from polyoxyethylene glyceryl monostearate and polyethylene glycol monostearate of HLB 9-16,
(C) at least one selected from amino acids, amino acid salts, and sodium dl-pyrrolidonecarboxylate;
(D) an alcohol having 1 to 3 carbon atoms;
(E) citric acid,
(F) sodium citrate;
The content of the component (D) is 20% by mass to 45% by mass, and the total content of the component (E) and the component (F) is 0.05% by mass to 0.3% by mass. A non-washing-type sterilizing detergent composition characterized by being filled in a former container and discharged in the form of foam.   The mass ratio (F) / (E) of the component (E) and the component (F) is 2 to 4, The sterilizing detergent composition of the type that does not wash away according to claim 1.