JP2013203676A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for oral cavity containing a cationic disinfectant and a cationic polymer and excellent in high temperature appearance stability of its formulation and in the effect of giving effective feeling (coating feeling) which gives users feeling of its effect.SOLUTION: A composition for oral cavity includes a cationic disinfectant (A), a cationic polymer (B) and lauroyl glutamate and/or myristoyl glutamate (C).

Description

  The present invention is an oral composition containing a cationic bactericide and a cationic polymer, which is excellent in high-temperature appearance stability of a preparation and excellent in an effective feeling (coating feeling) imparting an effect to the user. About.

In order to prevent periodontal disease and caries, suppression of plaque is important, and oral compositions containing a bactericide are widely used for the purpose of plaque suppression. Among these fungicides, cationic fungicides are widely used because they have bactericidal effects on oral bacteria, plaque-inhibiting effects, and gingivitis improving effects.
In addition, cationic polymers such as hydroxyethylcellulose dimethyldiallylammonium chloride have the property of being easily adsorbed on the tooth surface, and in combination with the cationic disinfectant cetylpyridinium chloride (CPC), plaque adhesion is suppressed. Patent Documents 1 and 2 (Japanese Patent Application Laid-Open Nos. 2011-148770 and 2001-139443) propose that the effect is synergistically improved.

  However, it has been difficult to ensure the appearance stability of the preparation by blending a cationic bactericide and a cationic polymer into the oral composition. Moreover, even if the composition for liquid oral cavity which mix | blended the cationic disinfectant contains the disinfectant, it was difficult for the user to realize the effect. In addition, the said technique which mix | blended the cationic fungicide and the cationic polymer is not considered at all about the actual feeling of an effect.

JP 2011-148770 A JP 2001-139443 A

Therefore, a product containing a cationic bactericidal agent and a cationic polymer, excellent in the appearance stability of the preparation, and giving the user a sense of effect by these components has not been completed.
The present invention has been made in view of the circumstances described above, and is a cationic sterilization that is excellent in appearance stability of a preparation, particularly high-temperature appearance stability, and has an effect of imparting an effective feeling (coating feeling) that gives an effect to the user. An object of the present invention is to provide an oral composition containing an agent and a cationic polymer.

  As a result of intensive studies to achieve the above object, the present inventor has found that (A) a cationic fungicide, (B) a cationic polymer, (C) lauroyl glutamate, and / or an oral composition. By blending with myristoyl glutamate, appearance stability, especially the occurrence of orientation over time at high temperature storage in liquid preparations is suppressed, and appearance stability at high temperature storage is excellent, and tooth surfaces etc. slip after use It was found that it was excellent in an effective feeling imparting effect that gives a coating feeling that it feels slippery, and that a feeling of effect by the components (A) and (B) can be satisfactorily imparted. In addition, it was found that the unpleasant taste due to the components (A) and (B) was suppressed and a good feeling of use was obtained.

Applicant, in Japanese Patent Application No. 2011-67845, when a cationic bactericidal agent and a cationized cellulose are blended with a liquid oral composition that does not contain ethanol, orientation will occur when stored for a long period of time at high temperatures, causing problems in appearance stability. In order to solve such problems, anethole effectively acts as a stabilizer, and by properly blending anethole with a polyhydric alcohol and / or a nonionic surfactant, the effect of preventing plaque adhesion, mu It was proposed to be superior in bactericidal effect and appearance stability. The present inventor has further investigated the improvement of the appearance stability of a preparation in which a cationic bactericide and a cationic polymer are blended in an oral composition. Surprisingly, lauroyl glutamate and / or myristoyl glutamate However, in preparations containing the above components (A) and (B), the occurrence of orientation after storage for 1 month at 50 ° C. in liquid preparations is suppressed to improve high-temperature appearance stability. It has been found that it can be imparted, and has led to the present invention.
In addition, although the composition of the acyl glutamate in the oral composition is known, lauroyl glutamate and / or myristoyl glutamate contributes to the improvement of the high-temperature appearance stability of the above preparation and the effect of imparting an effective feeling (A ), (B) and (C) The combined use of components (C) has been found by the present inventor to exhibit the above-mentioned special effects.
In Patent Document 1, a composition containing a cationic polymer and a cationic bactericidal agent and having good appearance stability is shown. This is appearance stability after storage for one month at a low temperature (5 ° C.), It is not orientation restraint after storage for 1 month at 50 ° C, and high temperature appearance stability. In addition, Patent Documents 1 and 2 do not consider the actual feeling of effect, and do not mention the provision of an effective feeling.

Therefore, the present invention
An oral composition comprising (A) a cationic fungicide, (B) a cationic polymer, and (C) lauroyl glutamate and / or myristoyl glutamate is provided.

  ADVANTAGE OF THE INVENTION According to this invention, it is excellent in the high temperature external appearance stability of a formulation, and for oral cavity containing the cationic disinfectant and the cationic polymer which were excellent in the effective feeling (coating feeling) provision effect which gives an effect feeling to a user. A composition can be provided.

The present invention will be described in further detail below.
The composition for oral cavity of the present invention comprises (A) a cationic fungicide, (B) a cationic polymer, and (C) lauroyl glutamate and / or myristoyl glutamate.

  Examples of the cationic fungicide as the component (A) include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and the like, and one or more of these can be used. In particular, cetylpyridinium chloride is preferable from the viewpoints of providing an effective feeling and usability.

  (A) 0.01 to 0.1% (mass%, the following is the same) of the whole composition is preferable, and, as for the compounding quantity of a cationic fungicide, 0.02 to 0.05% is more preferable. If it is less than 0.01%, even when combined with the components (B) and (C), there is a case where a coating feeling does not appear and an effective feeling may not be obtained. If it exceeds 0.1%, a nasty taste may occur and the feeling of use may decrease.

  (B) Component cationic polymer includes cationized cellulose, dimethyldiallylammonium homopolymer, copolymer of dimethyldiallylammonium chloride and polymerizable monomer having an ethylenically unsaturated hydrocarbon group, cationized polyvinyl Pyrrolidone, cationized polyamide, cationized polymethacrylate, cationized polyacrylamide, copolymer of cationized methacrylate and acrylamide, copolymer of cationized methacrylate and methacrylate, polyethyleneimide, cationized starch, cationized amylose, cationized guar gum, cationized Examples include roast bean gum, cationized agar, chitin, chitosan, and modified products thereof. These can be used individually by 1 type or in combination of 2 or more types. Among these, cationized cellulose is preferable in terms of effect expression.

As the cationized cellulose, cationized cellulose having a nitrogen content of 0.1 to 3% is particularly preferable.
Specific examples of the cationized cellulose include hydroxyethylcellulose / dimethyldiallylammonium salt obtained by graft polymerization of hydroxyethylcellulose and dimethyldiallylammonium salt (Cell Coat L-200, Cell Coat H-100, etc. manufactured by Nippon SC), hydroxyethyl cellulose. 2,3-epoxypropyltrimethylammonium chloride bound to O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose (Leonard MGP, Leogard HLP, Leogard GPS, Leogard KGP manufactured by Lion Corporation) , Leoguard G, Leoguard GP, Leoguard MLP) and the like.
Among these, Cellcoat L-200 (nitrogen content is 1.4 to 2.2%, 2% aqueous solution viscosity is 30 to 3,000 mPa · s (BH type Brookfield viscometer, rotor No. 2, 20 rotations) , 21 ° C., measurement time 1 minute), Cellcoat H-100 (nitrogen content 0.5 to 1.5%, 2% aqueous solution viscosity 500 to 2,750 mPa · s (BH Brookfield viscometer, Rotor No. 2, 20 revolutions, 21 ° C., measuring time 1 minute)), Leoguard MGP (nitrogen content 1.8%, 1% aqueous solution viscosity 500-1200 mPa · s (BH Brookfield viscometer) , Rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute)) is particularly preferable from the standpoint of effect.

  (B) As for the compounding quantity of a cationic polymer, 0.005-0.5% of the whole composition is preferable, More preferably, it is 0.01-0.05%. If it is less than 0.005%, the effective feeling may not be obtained satisfactorily even when combined with the components (A) and (C). If it exceeds 0.5%, orientation may occur and the high-temperature appearance stability may be impaired, or a nasty taste may occur and the feeling of use may be reduced.

  The component (C) is lauroyl glutamate and / or myristoyl glutamate. In the present invention, the use of lauroyl glutamate and / or myristoyl glutamate, among the acyl glutamates, can improve the high-temperature appearance stability in the combined system of the components (A) and (B). Giving an effective feeling. Other acyl glutamates do not exhibit the above-mentioned effects and cannot achieve the object of the present invention.

Examples of the salt of lauroyl glutamic acid and myristoyl glutamic acid include alkali metal salts such as sodium and potassium, alkaline earth metal salts, and organic amine salts. Examples thereof include sodium N-lauroyl-L-glutamate and sodium N-myristoyl-L-glutamate.
Specifically, Amino Surfact ALMS-P1 (N-lauroyl-L-glutamate sodium, Asahi Kasei Chemicals Corporation), Amisoft LS-11 (N-lauroyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.), Amino Surf AMMS-P1 (N-myristoyl-L-glutamate sodium, Asahi Kasei Chemicals Corporation), Amisoft MS-11 (N-myristoyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.) Can be used.

  Component (C) may be used singly or in combination of two, but lauroyl glutamate is particularly effective in imparting an effective feeling and high-temperature appearance stability, and has a weak taste and good usability. Therefore, it is preferable.

  Component (C) is preferably blended in an amount of 0.01 to 0.2%, more preferably 0.01 to 0.1% of the total composition. If it is less than 0.01%, the high-temperature appearance stability may not be improved or the effectiveness may be poor. Moreover, there may be a case where a decrease in the feeling of use (no taste) cannot be resolved. If it exceeds 0.2%, high-temperature appearance stability may be impaired. In addition, an off-flavor derived from the components may occur and the usability may be impaired.

In the present invention, the (A) and (B) components are combined with the (C) component to provide high temperature appearance stability and effective feeling (coating feeling) imparting effect. In this case, (A) More preferably, the component (C) is blended in an appropriate ratio with respect to the total amount of the component (B).
The blending ratio of the components (A), (B), and (C) is preferably 0.1 to 10, more preferably (C) component / [(A) component + (B) component]. Is 0.2-2. If the ratio is less than 0.1, the high-temperature appearance stability may not be improved or an effective feeling may not be obtained. Moreover, there may be a case where a decrease in the feeling of use (no taste) cannot be resolved. On the other hand, if it exceeds 10, high temperature appearance stability may be impaired. In addition, a nasty taste derived from the component (C) may occur and the feeling of use may be impaired.

The composition for oral cavity of the present invention is particularly suitable as a liquid preparation, and can be prepared and applied as a mouthwash, a mouth freshener, a liquid dentifrice or a dentifrice gel used by brushing with a toothbrush. It is particularly suitable as a mouthwash and liquid dentifrice.
In this case, in the composition of the present invention, in addition to the above components, appropriate known components according to the dosage form can be blended within a range that does not interfere with the effects of the present invention. For example, wetting agents, thickeners, sweeteners, fragrances, surfactants, active ingredients, colorants, preservatives, pH adjusters, solvents and the like can be blended. In addition, it is preferable not to contain an abrasive | polishing agent component from the point of especially effective feeling expression.

As the wetting agent, polyhydric alcohols such as propylene glycol and glycerin, and sugar alcohols such as xylitol and sorbit can be used alone or in combination. The amount is usually 2 to 20%.
Examples of the thickener include xanthan gum, carrageenan, sodium polyacrylate, sodium alginate, polyvinyl alcohol, hydroxyethyl cellulose, carboxymethyl cellulose sodium and the like. The amount is usually 0 to 3%.

  Examples of the sweetener include saccharin, saccharin sodium, stevioside, sucralose, reduced palatinose, erythritol, aspartame and the like.

  Examples of fragrances include peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Natural essential oil and l-menthol, l-carvone, cinnamic aldehyde, orange oil, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spiranthol Perfume ingredients contained in the above natural essential oils such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, Aldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate, etc. Perfume ingredients, plus some perfume ingredients and natural essential oils, apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. 1 type or 2 types or more of these compounded flavors. These fragrance | flavors are 0.00001 to 3% in a composition, and can be used in the range which does not prevent the effect of this invention.

  As the surfactant, anionic surfactants other than nonionic surfactants, lauroyl glutamate and myristoyl glutamate, amphoteric surfactants, and cationic surfactants can be blended.

As the nonionic surfactant, those usually compounded in oral compositions can be used. In particular, polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 60 to 100 moles, carbon number of alkyl group. Is 16 (cetyl) to 18 (stearyl) and the average addition mole number of ethylene oxide is 20 to 40 moles, and the fatty acid has 12 (lauric acid) to 18 (stearic acid), in particular, 12 to It is preferable to blend one or more selected from 14 (myristic acid) decaglycerin monofatty acid esters from the viewpoint of improving high-temperature appearance stability. Of these, polyoxyethylene hydrogenated castor oil is preferred. If the average added mole number of ethylene oxide is too small, the high-temperature appearance stability may not be improved. Those that are too large are generally not commercially available.
For example, the following commercial products are mentioned.
Polyoxyethylene hydrogenated castor oil ・ NIKKOL HCO system manufactured by Nikko Chemicals Co., Ltd. ・ Emarex HC system manufactured by Nihon Emulsion Co., Ltd. ・ Uniox HC system manufactured by Nikko Co., Ltd. Polyoxyethylene alkyl ether ・ Japan emulsion ( Emalex 100 series manufactured by Japan Emulex 600 series manufactured by Japan Emulsion Co., Ltd. Decaglycerin monofatty acid ester NIKKOL Decagln system manufactured by Nikko Chemicals Co., Ltd. Ryoto manufactured by Mitsubishi Chemical Foods Co., Ltd. ) Polyglycerin D series, etc. The blending amount of these nonionic surfactants is preferably 0 to 2%, particularly preferably 0.5 to 1% of the entire composition.

Specific examples of surfactants include anionic surfactants such as alkyl sulfates such as sodium lauryl sulfate, lauroylmethyl taurine, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, and alkyl phosphate ester salts. Agents, betaine acetate type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, fatty acid amidopropyldimethylaminoacetic acid betaine, imidazoline type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt, Examples thereof include amino acid type surfactants such as N-fatty acid acyl-L-alginate salts.
In addition, the compounding quantity of the said surfactant has the preferable range that the total amount including (C) component will be 0.01 to 5%, especially 0.2 to 2%.

  Active ingredients include, for example, bactericides such as chlorhexidine hydrochloride and alkyldiaminoethylglycine hydrochloride, anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, allantoin, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, dextranase, amylase, Enzymes such as protease, mutanase, lysozyme, lytic enzyme, lytechenzyme, fluoride such as sodium fluoride, sodium monofluorophosphate, stannous fluoride, vitamin C such as azulene, lysozyme chloride, ascorbic acid, dihydrocholesterol , Glycyrrhetin salts, Glycyrrhetinic acids, Hydrocholesterol, Chlorophyll, Copper chlorophyllin sodium, Thyme, Ogon, Clove, Hamamelis and other plant extracts Copper gluconate, Karopeputaido, sodium polyphosphate, water-soluble inorganic phosphoric acid compounds, polyvinylpyrrolidone, anti-tartar agents, anti-plaque agents, potassium nitrate, may be added to aluminum lactate and the like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105 can be added.
As the pH adjuster, a commonly used organic acid or a salt thereof such as citric acid, phosphoric acid, a sodium salt thereof, a potassium salt, or the like can be used. The pH of the composition is preferably adjusted to 5.5 to 8.5, and citric acid and sodium citrate, or sodium dihydrogen phosphate and sodium monohydrogen phosphate are used as pH adjusting agents in the vicinity of the composition. Combinations can be used.

As the solvent, purified water is blended, and the blending amount can be 60% or more, particularly 70% or more.
Moreover, ethanol may be included if necessary, and its content is preferably 0 to 10%, particularly preferably 0 to 5%.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

The details of the raw materials used are as follows.
・ Cetylpyridinium chloride (Wako Pure Chemical Industries, Ltd.)
・ Benzethonium chloride (Highamine 1622: Lonza Japan)
Hydroxyethyl cellulose dimethyl diallylammonium chloride (Cell Coat L-200, Cell Coat H-100: manufactured by NSC Japan)
O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethylcellulose chloride (Leoguard MGP: manufactured by Lion)
-Sodium N-lauroyl-L-glutamate (Amino Surfact ALMS-P1: Asahi Kasei Chemicals)
-Sodium N-myristoyl-L-glutamate (Amino Surfact AMMS-P1: manufactured by Asahi Kasei Chemicals Corporation)
・ Lauroyl sarcosine sodium (Soipon SLP: Kawaken Fine Chemical Co., Ltd.)
・ Polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (100) hydrogenated castor oil (Nikko Chemicals)
・ Propylene glycol (Asahi Glass Co., Ltd.)
・ Glycerin (85% product, Sakamoto Pharmaceutical Co., Ltd.)
・ Xylitol (Rocket Fleure)
・ Citric acid (manufactured by Fuso Chemical)
・ Sodium citrate (manufactured by Fuso Chemical)
・ Saccharin sodium (Daito Chemical Co., Ltd.)
The composition of the fragrance A is shown in Tables 4 to 10 described later.
For other ingredients, those conforming to the Quasi-drug Raw Material Standard 2006 were used.

[Examples and Comparative Examples]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in Tables 1-3. In addition, the compounding quantity in a table | surface is a pure amount.

[1] Evaluation Method of High-Temperature Appearance Stability (No Orientation) 450 mL of a sample (liquid oral composition) is filled into a colorless and transparent PET container (manufactured by Yoshino Kogyo Co., Ltd.) of 500 mL, and a 50 ° C. constant temperature bath ( Sanyo Electric Co., Ltd., MPR-311) was visually evaluated for high-temperature appearance stability (no orientation) after storage for 1 month according to the following criteria. B or higher was accepted.
Evaluation criteria for high-temperature appearance stability (no orientation):
AA: Even if shaken, no orientation is recognized.
A: Even if shaken, orientation is hardly recognized.
B: Although very small orientation is recognized when shaken, it is a level with no problem.
C: Slight orientation is observed.
D: Considerable orientation is recognized.

[2] Effectiveness (coating feeling) imparting effect evaluation method A sample (liquid oral composition) containing about 10 mL in the mouth, rinsed for 30 seconds, and then the effective feeling of the tooth surface after mouthwashing in the following five stages The average score of 10 persons was indicated by AA, A, B, C, and D according to the following criteria.
Here, the sense of effectiveness (coating feeling) means that when the teeth are engaged, the tooth surface can be felt as if it is coated and slips, or the tooth surface, upper jaw, and lower jaw can be touched with the tip of the tongue. It is an actual feeling that you can feel that it is slippery. B or higher was accepted.
Evaluation criteria for effectiveness (coating feeling) imparting effect:
5 points: There was a feeling of coating.
4 points: There was some coating feeling.
3 points: There was a slight coating feeling.
Two points: There was almost no coating feeling.
1 point: There was no coating feeling.
Criteria for effect of imparting effectiveness (coating feeling):
AA: Average point 4.0 points or more and 5.0 points or less A: Average point 3.5 points or more and less than 4.0 points B: Average point 3.0 points or more and less than 3.5 points C: Average point 2.0 points Above 3.0 and below D: Average point below 2.0

[3] Evaluation method of feeling of use (no taste) The sample contains 5 ml of sample (liquid oral composition) in the mouth, rinses for 30 seconds, and after use for mouthfeel (no taste). The average score of 10 people was indicated by AA, A, B, C, and D according to the following criteria. B or higher was accepted.
Evaluation criteria for feeling of use (no taste):
5 points: No nasty taste.
4 points: There was almost no nasty taste.
3 points: Slightly off-flavor but no problem.
2 points: There was a slight taste.
1 point: There was a nasty taste.
Criteria for feeling of use (no taste):
AA: Average point 4.0 points or more and 5.0 points or less A: Average point 3.5 points or more and less than 4.0 points B: Average point 3.0 points or more and less than 3.5 points C: Average point 2.0 points Above 3.0 and below D: Average point below 2.0

  A prescription example is shown below. The formulation examples were prepared using the same raw materials as described above and evaluated in the same manner, and as a result, they were excellent in high-temperature appearance stability, effectiveness imparting effect, and usability.

[Prescription Example 1] Mouthwash (A) Cetylpyridinium chloride 0.05%
(B) Hydroxyethylcellulose dimethyldiallylammonium chloride (Cellcoat L-200) 0.01
(C) Sodium N-lauroyl-L-glutamate 0.05
Polyoxyethylene (100) hardened castor oil 0.5
Propylene glycol 3
Glycerin 3.825
Xylitol 3
Citric acid 0.03
Sodium citrate 0.25
Saccharin sodium 0.004
Fragrance A 0.2
Purified water balance
Total 100.0%
(C) / [(A) + (B)] = 0.8

[Prescription Example 2] Mouthwash (A) Cetylpyridinium chloride 0.05%
(A) Benzethonium chloride 0.01
(B) Hydroxyethylcellulose dimethyldiallylammonium chloride (Cellcoat L-200) 0.01
(C) Sodium N-lauroyl-L-glutamate 0.05
Polyoxyethylene (100) hardened castor oil 0.5
Propylene glycol 3
Glycerin 3.825
Xylitol 3
Citric acid 0.03
Sodium citrate 0.25
Saccharin sodium 0.004
Fragrance A 0.2
Purified water balance
Total 100.0%
(C) / [(A) + (B)] = 0.7

[Prescription Example 3] Dentifrice (A) Cetylpyridinium chloride 0.05%
(B) Hydroxyethylcellulose dimethyldiallylammonium chloride (Cellcoat L-200) 0.01
(C) Sodium N-lauroyl-L-glutamate 0.05
Sorbit 28
Propylene glycol 3
Xanthan gum 0.7
Sodium polyacrylate 0.4
Saccharin sodium 0.2
Titanium oxide 0.3
Sodium lauryl sulfate 1.2
Fragrance A 0.8
Silicic anhydride 18
Purified water balance
Total 100.0%
(C) / [(A) + (B)] = 0.8

表中、部は質量部である（以下、同様。）。

In the table, parts are parts by mass (the same applies hereinafter).

Claims (7)

  An oral composition comprising (A) a cationic fungicide, (B) a cationic polymer, and (C) lauroyl glutamate and / or myristoyl glutamate.   The composition for oral cavity according to claim 1, wherein the component (A) is cetylpyridinium chloride.   The composition for oral cavity according to claim 1 or 2, wherein the component (B) is cationized cellulose.   The composition for oral cavity according to claim 1, 2 or 3, wherein the component (C) is lauroyl glutamate.   (A) The composition for oral cavity of any one of Claims 1 thru | or 4 which contains 0.01-0.1 mass% of component.   (B) The composition for oral cavity of any one of Claims 1 thru | or 5 which contains a component 0.005-0.5 mass%.   The composition for oral cavity according to any one of claims 1 to 6, wherein (C) component / [(A) component + (B) component] is 0.1 to 10 as a mass ratio.