JP5682235B2 - Dentifrice composition and method for improving foam performance of oral dentifrice composition and retention in mouth of oil-soluble component - Google Patents

Description

  The present invention relates to a dentifrice composition and a dentifrice composition excellent in feeling of use, particularly foaming at the time of toothbrushing, foam creamy feeling, foam persistence such as foam persistence and absence of foaming, and retention in the mouth of oil-soluble active ingredients. The present invention relates to a method for improving the foam performance and the in-mouth retention of oil-soluble components.

  Among the feeling of use of dentifrice, the feeling of foam in the oral cavity is one of the textures that can feel a feeling of cleaning. However, saliva is constantly secreted into the oral cavity, and if the teeth are brushed for a long time, the dentifrice is diluted with saliva, so that the foam does not persist. Further, the bubbles do not last and the cleaning feeling is reduced. Moreover, even if the foam persisted, the foam dropped from the mouth, and it was difficult to brush the teeth for a long time. Further, the creamy feeling of foam was not felt, and the polished satisfaction was inferior. Therefore, it is effective for improving the feeling of use of the dentifrice to improve the feeling of foam.

  On the other hand, the dentifrice composition contains a bactericidal agent, an antibacterial agent, an anti-inflammatory agent, a blood circulation promoter, and the like as active ingredients for preventing gum defects. In order to further enhance the effects of these components, studies have been made to increase the retention of these components in the mouth. A technology that uses sodium alginate and xanthan gum together (see Patent Document 1) to improve the retention in the mouth of triclosan, a nonionic fungicide, and gellan gum stably by using gellan gum and a nonionic surfactant. In addition, a technique (see Patent Document 2) that improves the retention in the mouth of medicinal components such as tocopherol acetate as a blood circulation promoter and isopropylmethylphenol as a bactericide has been proposed.

  In addition, it is considered that it is effective to act in the mouth for a long time in order to further increase the retention in the mouth with the active ingredients that prevent these gum problems, so it is possible to brush the teeth for a long time. This is an effective means. However, when the teeth are brushed over a long period of time, the foam performance tends to decrease as described above, and it is difficult to maintain a good foam feeling.

  Regarding the foam performance of dentifrices, the applicant has determined that a dentifrice composition containing polyvinylpyrrolidone, fatty acid diethanolamide or polyoxyethylene hydrogenated castor oil, and alkyl sulfate in order to retain the foam during dentifrice for a long time in the oral cavity (Patent Document) 3), xanthan gum, polyvinylpyrrolidone, sorbit, alkyl sulfate, and titanium oxide (see Patent Document 4). However, in recent years, due to the growing awareness of oral self-care in the home, such as carefully polishing between the teeth and the boundary between teeth and gums, there is a need for a dentifrice composition that maintains a more creamy feeling and does not drool. ing.

  Although the dentifrice of the composition which mix | blended sodium lauryl sulfate, xanthan gum, and an amphoteric surfactant is described in patent documents 5-6, patent document 5 and 6 WHEREIN: The foam feeling and vitamin E which were excellent by setting it as this-application structure. Alternatively, it is difficult to predict that a preparation having the retention in the mouth of oil-soluble components such as derivatives thereof will be obtained. Patent Document 7 discloses a technology in which foaming and foam persistence are improved by blending a relatively large amount of anionic surfactant and a nonionic surfactant into a composition containing xanthan gum and sodium alginate. It has been proposed, but it has not been shown to provide a dentifrice composition that lasts more creamy and does not sag.

  In addition, when the inventor examined, the dentifrice composition of the composition described in Patent Documents 3, 4, and 7 cannot be said to have sufficient foam sustaining effect and foamy creamy feeling. The object of the invention was not achieved.

  In Patent Document 8, by adding xanthan gum, sodium lauryl sulfate, and a betaine-type amphoteric surfactant to a dentifrice composition containing sodium chloride, foaming properties and foam persistence are maintained while maintaining good gingival tightening feeling. Improved technology has been proposed. However, when the present inventors similarly examined, the dentifrice composition described in Patent Document 8 was not sufficiently free of bubbles and there was still room for improvement in the feeling of foam.

JP-A-7-187975 JP-A-8-3074 JP 11-209255 A JP 2009-149540 A JP 2007-145740 A JP 2009-84277 A JP 2006-347987 A JP 2009-137908 A

Therefore, in a dentifrice composition containing an oil-soluble active ingredient such as vitamin E or a derivative thereof, a high foam feeling is maintained even after tooth brushing for a long time, and the feeling of use is good, and the oil-soluble active ingredient stays in the mouth. Although superiority is effective and desirable for the expression of the effect of the active ingredient, in the prior art, excellent foaming during tooth brushing, foam persistence, foam creaminess, no foam dripping, and retention of oil-soluble ingredients in the mouth It was difficult to combine all the goodness of sex.
The present invention has been made in view of the above circumstances, has excellent foaming feeling in foaming, persistence of foaming, foamy creaminess, and no foaming during brushing, and in the mouth retention of oil-soluble components An object of the present invention is to provide an excellent dentifrice composition containing an oil-soluble active ingredient and a method for improving the foam performance of the dentifrice composition and the retention in the mouth of the oil-soluble ingredient.

As a result of intensive studies to achieve the above object, the present inventor has developed (A) a dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E or a derivative thereof, triclosan, and isopropylmethylphenol. Xanthan gum 1.4-2.5 mass% and (B) alkyl sulfate 1.4-2.5 mass% are blended at a mass ratio of (A) / (B) of 0.7-1.5. (C) By using 0.05 to 1.5% by weight of the amphoteric surfactant, surprisingly, the foaming at the time of brushing, the persistence of the foam, the creamy feeling of the foam, and the absence of foam It has been found that an excellent and high foam feeling can be obtained, and a preparation excellent in the mouth retention of the oil-soluble component can be obtained.

  That is, xanthan gum, alkyl sulfate, and amphoteric surfactant are all known as ingredients of dentifrice compositions. However, xanthan gum is usually blended in dentifrice compositions as a binder. However, when xanthan gum is blended at a high concentration, there are problems that the preparation becomes too hard and foaming becomes poor, and thus 1.2% by mass. The above high concentration was rarely added and was not common. Moreover, although an anionic surfactant improves foaming, it is difficult to satisfactorily improve even when the feeling of foaming, especially the creamy feeling and foaming feeling of the foam is brushed for a long time. Furthermore, it is generally considered that when the amount of the anionic surfactant increases, the solubilizing power increases, so that the oil-soluble component does not easily stay in the oral cavity, and it is difficult to obtain sufficient retention in the mouth.

On the other hand, in the present invention, xanthan gum is blended in a dentifrice composition containing the oil-soluble component at a concentration higher than the usual blending amount, and the blending ratio of both components is combined with a specific amount of alkyl sulfate. By adjusting to an appropriate range, the foam performance is improved, high foam feeling is obtained, the retention in the mouth of the oil-soluble component is increased, and amphoteric surfactants, preferably alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine In combination with one or more amphoteric surfactants selected from 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, the foam performance, particularly foam creamy feeling and dripping, This improves the retention of the oil-soluble component in the mouth. According to the present invention, the problems in the above dentifrice composition can be solved, and the foam feel is excellent. In particular, even when brushing for a period of time longer than the normal toothbrushing time (about 3 minutes), for example, about 5 minutes, the creamy feeling is excellent. The foam lasts and there is no dripping, a good feeling of use is obtained, and the oil-soluble component can be sufficiently retained in the mouth. This is clear also from the Example mentioned later, and in this invention, when any essential requirement is lacked, the said effect is not show | played but the objective of invention cannot be achieved.
In the present invention, by further adding (D) a chelating agent, the retention of the chelating agent on the tooth surface is enhanced, and in addition to the foam performance and the oil-soluble component retention, the effect of removing colored stains on the teeth is also excellent. A formulation can be obtained.

Accordingly, the present invention provides the following dentifrice composition and a method for improving the foam performance of the dentifrice composition and the retention in the mouth of the oil-soluble component.
Claim 1:
A dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E and its derivatives, triclosan, isopropylmethylphenol, (A) 1.4 to 2.5% by mass of xanthan gum and (B) alkyl sulfate 1 .4 to 2.5% by mass with (A) / (B) mass ratio of 0.7 to 1.5, and (C) 0.05 to 1.5 % by mass of amphoteric surfactant. A dentifrice composition characterized by the above.
Claim 2:
(C) The dentifrice according to claim 1, wherein the amphoteric surfactant is at least one selected from alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine. Composition .
Claim 3 :
Furthermore, the dentifrice composition of Claim 1 or 2 which mix | blended 0.1-5 mass% of (D) chelating agents.
Claim 4 :
The dentifrice composition according to claim 3 , wherein the component (D) is one or more selected from linear polyphosphate, malic acid, and phytic acid.
Claim 5:
The dentifrice composition according to any one of claims 1 to 4, which is a toothpaste composition.
Claim 6:
A dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E and its derivatives, triclosan, isopropylmethylphenol, (A) 1.4 to 2.5% by mass of xanthan gum and (B) alkyl sulfate 1 .4 to 2.5% by mass with (A) / (B) mass ratio of 0.7 to 1.5, and (C) 0.05 to 1.5 % by mass of amphoteric surfactant. A method for improving the foam performance of the dentifrice composition and the retention in the mouth of the oil-soluble component.

  According to the present invention, in a dentifrice composition containing an oil-soluble active ingredient, foaming feeling, especially foaming during brushing, foam persistence, foam creaminess, no foaming, and the mouth of the oil-soluble ingredient A dentifrice composition having excellent retention can be provided. ADVANTAGE OF THE INVENTION According to this invention, even if it brushes for a long time, a foam feeling is good and a usability | use_condition is good, The effect derived from the oil-soluble active ingredient mix | blended with the dentifrice composition can be expressed more effectively. Furthermore, (D) By mix | blending a chelating agent, in addition to the said foam performance and oil-soluble component retention property, the formulation excellent also in the colored stain removal effect of a tooth | gear can be provided.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is suitably prepared as a dentifrice such as a toothpaste, a liquid dentifrice, and a toothpaste, particularly a toothpaste, and is one or more oils selected from vitamin E or a derivative thereof, triclosan, and isopropylmethylphenol. Toothpaste composition containing soluble component, (A) xanthan gum, (B) alkyl sulfate, and (C) amphoteric surfactant as essential components, as foam performance improver and oil-soluble component oral retention improver It is a thing.

Vitamin E or a derivative thereof is an active ingredient that promotes gum circulation and provides a preventive effect on gingivitis. As vitamin E or a derivative thereof, various vitamin E or a derivative thereof usually blended in a dentifrice composition, for example, dl-α-tocopherol, dl-tocopherol acetate, dl-α-tocopherol nicotinate, dl-α-succinate A tocopherol etc. are mentioned. Among these, dl-α-tocopherol acetate is preferable because it hardly affects the color tone and appearance of the preparation. For example, dl-α-tocopherol acetate is available from DSM Nutrition Japan.
The blending amount of vitamin E or a derivative thereof is preferably 0.01 to 5% (mass%, the same applies hereinafter), particularly 0.05 to 1%, based on the effectiveness and taste. If the blending amount is less than 0.01%, sufficient pharmacological effects may not be exhibited. If the blending amount exceeds 5%, it may be difficult to solubilize in the preparation, causing problems in appearance stability, or inferior in taste. There is.

Triclosan is a halogenated diphenyl ether type fungicide and has a chemical name of 2 ′, 4, 4′-trichloro-2-hydroxydiphenyl ether, and can be obtained from Ciba Specialty Chemicals.
The blending amount of triclosan is preferably 0.001 to 2% of the whole composition, particularly 0.01 to 0.5% from the viewpoint of the bactericidal effect. If the blending amount is less than 0.001%, a sufficient bactericidal effect may not be exhibited, and if it exceeds 2%, irritation may occur.

Isopropylmethylphenol is 4-isopropyl-3-methylphenol, and specifically, commercially available products such as trade name Biosol (manufactured by Osaka Kasei Co., Ltd.) can be used.
The blending amount of isopropylmethylphenol is preferably 0.01 to 0.2%, particularly 0.02 to 0.1% of the total composition, and if it is less than 0.01%, a sufficient bactericidal effect may not be exhibited. If it exceeds 0.2%, the taste may be deteriorated, for example, an odor derived from isopropylmethylphenol may occur and the taste may deteriorate.
In addition, the said oil-soluble active ingredient may be used individually by 1 type, or may use 2 or more types together, Each can mix | blend an effective amount.

  (A) As xanthan gum, a commercially available product can be used, for example, Novazan manufactured by ADM Far East Co., Ltd., Monart Gum DA manufactured by Kelco Co., Ltd., Kelzan T, Keldent, Echo Gum manufactured by Dainippon Pharmaceutical Co., Ltd. Etc.

  (A) The compounding quantity of a xanthan gum is 1.4 to 2.5% of the whole composition, Preferably it is 1.6 to 2%. If the blending amount is less than 1.4%, a sufficient foamy creamy feeling cannot be obtained, and the lack of bubble dripping is inferior. If it exceeds 2.5%, it is inferior to foaming, foam creamy feeling, foam persistence, and foam dripping.

  (B) As the alkyl sulfate, those having 8 to 18, particularly 12 to 14 carbon atoms of the alkyl group are suitable, and alkali metal salts such as sodium salts and potassium salts are used. If the alkyl group has less than 8 carbon atoms, irritation may be felt at the time of use, and the taste may deteriorate, and if it exceeds 18, foaming may be deteriorated.

  Specific examples of the alkyl sulfate include potassium lauryl sulfate, sodium lauryl sulfate, triethanolamine lauryl sulfate, sodium myristyl sulfate, sodium cetyl sulfate, and sodium lauryl sulfate is particularly preferable from the viewpoint of solubility and feeling of use. It is. In addition, the alkyl sulfate can use a commercial item, for example, sodium lauryl sulfate can use the product made by Toho Chemical Industry Co., Ltd., Nikko Chemicals Co., Ltd., etc.

  The compounding amount of the alkyl sulfate is 1.4 to 2.5%, preferably 1.6 to 2.2% of the whole composition. If the blending amount is less than 1.4%, foaming, foamy creamy feeling, foam persistence, and lack of foam are inferior. If it exceeds 2.5%, the creamy feeling of the foam and the lack of dripping are inferior. In addition, the feeling of use deteriorates, such as irritation in the oral cavity.

  The mass ratio of the component (A) / the component (B) needs to be 0.7 to 1.5, and particularly preferably 0.8 to 1.3. When the mass ratio of the component (A) / the component (B) is less than 0.7, the creamy feeling of the foam and the lack of bubble dripping are inferior. If it exceeds 1.5, foaming, foamy creaminess, and foam persistence are inferior.

  (C) Examples of the amphoteric surfactant include alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine and the like.

As the alkyl chain length of the amphoteric surfactant, the number of carbon atoms of the alkyl chain length is preferably 8 to 20, particularly 10 to 18 from the viewpoint of good foaming and foam creaminess.
Specific examples of the alkyldimethylaminoacetic acid betaine include lauryldimethylaminoacetic acid betaine, and examples of the fatty acid amidopropyl betaine include coconut oil fatty acid amidopropyl betaine and lauric acid amidopropyl betaine. Examples of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine include N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine.
Among these, fatty acid amidopropyl betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine are particularly preferred from the viewpoint of foaming, and palm oil fatty acid amidopropyl betaine is particularly easy to mix and use. From the viewpoint of sex.

As an example of alkyldimethylaminoacetic acid betaine, an aqueous solution of lauryldimethylaminoacetic acid betaine sold by Nikko Chemicals Co., Ltd. under the trade name NIKKOL AM-301 can be used.
Examples of fatty acid amidopropyl betaines include the use of coconut oil fatty acid amidopropyl betaine aqueous solution sold by Degussa as trade names TEGO BetainCK, TEGO BetaF50, and TEGO BetaFine ZF, Enagicol C-30B manufactured by Lion Co., Ltd. it can.
In addition, as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N- sold by Lion Corporation under the trade name Enadicol C-40H Hydroxyethyl imidazolium betaine aqueous solution or the like can be used, but in any case, it is not limited to the above.

  These amphoteric surfactants may be used alone or in combination of two or more. Further, the blending amount is 0.05 to 1.5%, particularly 0.1 to 1% of the whole composition as a pure component in terms of foaming, foamy creaminess, and lack of foam. It is preferable. If the blending amount is less than 0.05%, it is inferior to the creamy feeling of foam and the absence of foam, and if it exceeds 1.5%, the retention of the oil-soluble component and the stability over time of the preparation may be inferior. Moreover, the bitterness peculiar to an amphoteric surfactant may arise.

(D) The chelating agent is blended as a tooth stain remover. In the present invention, the retention of the chelating agent on the tooth surface is improved, and the effect of removing colored stains on the teeth can be enhanced together with excellent foam performance and oil-soluble component retention.
Examples of the chelating agent include linear polyphosphate, malic acid, phytic acid and the like.
The linear polyphosphate has the following general formula (1)
M _{n + 2} P _n O _{3n + 1} (1)
(However, M represents Na or K, and n is an integer of 2 to 3.)
The sodium pyrophosphate having a polymerization degree of n = 2 (made by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.) or potassium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Toa Gosei Chemical Co., Ltd.) Etc.), n = 3 sodium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.) and potassium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.) 1 type, or 2 or more types can be used. If n exceeds 3, the feeling after brushing may worsen.
When linear polyphosphoric acid is mix | blended as a chelating agent, the compounding quantity is 0.1 to 3% of the whole composition, and 0.5 to 2.5% is especially suitable.

  Malic acid is a kind of hydroxy acid. As malic acid, an acid or a salt thereof can be used. As the salt, sodium salt, potassium salt and the like can be used. Specifically, malic acid and its sodium salt are mentioned, and a commercial item can be used. When malic acid is blended, the blending amount is preferably 0.1 to 5%, particularly 0.5 to 3% of the entire composition.

  As phytic acid, an acid or a salt thereof can be used. As the salt, sodium salt, potassium salt and the like can be used. Specific examples include phytic acid (manufactured by Tsukino Food Industry Co., Ltd.). When phytic acid is blended, the blending amount is preferably 0.1 to 3%, particularly 0.5 to 2.5% of the entire composition.

  (D) As a chelating agent, the 1 type (s) or 2 or more types of the said compound can be mix | blended, and the total compounding quantity in the case of mix | blending is 0.1 to 5% of the whole composition, and 0.5 to 3% is especially preferable. If the blending amount is less than 0.1%, the effect of removing the colored stains on the teeth may not be sufficiently exhibited while maintaining high foam performance. If the blending amount exceeds 5%, irritation in the oral cavity may be felt, and the feeling of use becomes worse. There is.

  In the dentifrice composition of the present invention, in addition to the above-mentioned components, various other components that are usually used in dentifrice compositions can be blended as necessary within the range not impairing the effects of the present invention. Optional ingredients that can be blended include a binder, a surfactant, an abrasive, a wetting agent, a sweetener, a fragrance, a pH adjuster, an active ingredient or a medicinal ingredient, and an antiseptic.

  As the binder, other than xanthan gum, for example, inorganic binders such as thickening silica and aluminum silicate, sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, sodium alginate, tragacanth gum, caraya gum, arabic gum, Organic binders such as locust bean gum, polyvinyl alcohol, sodium polyacrylate, cross-linked sodium polyacrylate, carboxyvinyl polymer, carbopol, and beegum may be blended. These binders may not be blended, but the blending amount when added is preferably in the range of 1.4 to 2.5% of the total composition in total with xanthan gum.

As the surfactant, any one of anionic surfactants other than alkyl sulfates, cationic surfactants and nonionic surfactants may be used alone or in combination of two or more.
Anionic surfactants other than alkyl sulfates include sodium N-lauroyl sarcosinate, sodium N-myristol sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate N-acyl glutamates such as sodium α-olefin sulfonate and sodium N-palmitoyl glutamate, and N-acyl taurates such as sodium N-methyl-N-acyl taurate.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.

Nonionic surfactants include polyglycerin fatty acid esters, sucrose fatty acid esters, sucrose fatty acid esters such as maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactol fatty acid esters, alkylol amides, polyoxy Polyoxyethylene sorbitan fatty acid ester such as ethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether , Polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, pluronic and the like.
The total amount of surfactants including alkyl sulfates and amphoteric surfactants is preferably 5% or less, particularly 1.45 to 3% of the total composition.

Examples of abrasives include dicalcium phosphate dihydrate and anhydrous salts, calcium phosphate compounds such as primary calcium phosphate, tertiary calcium phosphate, and calcium pyrophosphate, silica-based abrasives such as precipitated silica and aluminosilicate, calcium carbonate, Calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, etc., or one or more of granulated products of these components can be blended.
The blending amount of the abrasive is usually 0 to 25%, particularly 2 to 20% of the whole composition.

  Examples of the wetting agent include sorbitol, glycerin, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000, ethylene glycol, 1,3-butylene glycol, erythritol, reduced starch saccharified polyhydric alcohol, sugar alcohol One kind can be blended alone or in combination of two or more kinds. The blending amount is preferably 28 to 50% of the entire composition.

  Examples of sweeteners include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, and the like. The compounding quantity of a sweetener is 0.01 to 5% of the whole composition normally.

  As a fragrance, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange Oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like. The compounding quantity of the fragrance | flavor in a composition can be 0.001-2%.

  Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

  Medicinal ingredients or active ingredients include those other than the above oil-soluble ingredients, such as enzymes such as dextranase, amylase, protease, mutanase, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid Antibacterial agents such as sodium chloride and vitamins, copper chlorophyll, copper gluconate, cetylpyridium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride and the like, and amino acids such as glycine and proline can be added. In addition, the compounding quantity of a medicinal ingredient or an active ingredient can be made into an effective quantity in the range which does not prevent the effect of this invention.

  In addition, as an optional component, inorganic compounds such as calcium hydrogen phosphate, zeolite, hydroxyapatite, titanium mica, titanium oxide and the granulated product thereof, a granulated product of cellulose organic powder such as crystalline cellulose, agar, Natural polymer compounds such as gelatin, starch, glucomannan, synthetic polymer compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder and copolymers thereof, carnauba wax, rosin, Obtained by crosslinking, polymerization, molding, etc., waxes such as rice wax, microcrystalline wax, beeswax and paraffin wax, higher alcohols such as cetanol and stearyl alcohol, and latex rubbers such as polyisobutylene, polybutadiene, urethane, silicone and natural rubber Those were, or can be used and lame film those obtained by mixing these materials. Lame films include organic resin laminated film powder, laminated film powder in which a vapor deposition layer such as aluminum is introduced into the organic resin laminated film, specifically, polyethylene terephthalate / polymethyl methacrylate laminated film powder, polyethylene terephthalate・ Aluminum / epoxy laminated powder or the like can be blended within a range not impeding the effects of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% is mass% unless otherwise specified. Moreover, 70% solution was used for sorbit, 30% solution or 35% solution was used for the amphoteric surfactant, and the blending amounts in the table shown below were expressed as pure amounts.

Examples and comparative examples
The dentifrice compositions shown in Tables 1 to 3 were prepared by the following production method. The resulting dentifrice composition was evaluated for foam feeling (good foaming, foam creamy feeling, foam persistence, no foam dripping) and retention in the mouth of oil-soluble components by the following methods. The results are shown in the table.

Manufacturing method of dentifrice composition:
A water-soluble component containing sorbit and / or glycerin in purified water was mixed and dissolved at room temperature (phase A). Phase B, in which xanthan gum and / or carboxymethylcellulose was dispersed in propylene glycol at room temperature, was added and mixed into phase A under stirring to prepare phase C. Vitamin E or its derivatives, triclosan and isopropylmethylphenol were dissolved in the perfume. In phase C, a fragrance, an abrasive, and a surfactant were mixed at room temperature using a kneader (manufactured by Ishiyama Kogakusho), and defoamed under reduced pressure (5.3 kPa) to obtain a dentifrice composition.

<Good foaming, foamy creamy feeling, persistence of foam, lack of dripping>
Evaluation was conducted by a sensory test using 10 professional panelists. The test dentifrice composition filled in a laminated tube with a diameter of 8 mm is placed on a toothbrush about 1.5 cm and is used for 5 minutes by the usual brushing method. Good foaming, foam creaminess, foam persistence, foam dripping The absence was evaluated according to the following criteria. Each was determined according to Evaluation Criteria-5 from the average score of 10 results based on Evaluation Criteria-1 to Evaluation Criteria-4 shown below.

Evaluation criteria-1
Good foaming 5 points: Very well foamed 4 points: Well foamed 3 points: Foamed 2 points: Almost no foaming 1 point: Evaluation standard -2 no foaming at all
Creamy feeling of foam 5 points: Feels very creamy 4 points: Feels quite creamy 3 points: Feels slightly creamy 2 points: Does not feel so much creamy 1 point: Does not feel creamy at all

Evaluation criteria-3
Persistence of foam 5 points: Very well after 5 minutes of brushing 4 points: Foam was well after 5 minutes of brushing 3 points: Foam was formed after 5 minutes of brushing 2 points: After 5 minutes of brushing, there was almost no foaming. 1 point: Evaluation standard 4 with no foaming after 5 minutes of brushing
No bubbling 5 points: No bubbles from the mouth even after 5 minutes of brushing 4 points: Little bubbling from the mouth even after 5 minutes of brushing 4 points: Mouth before 5 minutes of brushing 2 points: Foaming from the mouth before 5 minutes of brushing 1 point: Foaming from the mouth before 2 minutes of brushing

Evaluation Criteria-5; (Judgment Criteria for Averaged Evaluation Results of 10 Expert Panelists)
◎: Average score is 4.5 or more and 5.0 or less ○: Average score is 4.0 or more and less than 4.5 △: Average score is 3.0 or more and less than 4.0 ×: Average score is Less than 3.0

<Evaluation of retention in the mouth of oil-soluble components>
The method for evaluating the retention in the mouth of vitamin E or its derivatives, triclosan and isopropylmethylphenol is shown below.
50 ml of a dentifrice diluted solution obtained by diluting the test dentifrice composition 3 times with water was put in a beaker and stirred until it was uniform, brought to 37 ° C. in a water bath, and sufficiently foamed with a milk foamer. One spoonful (about 1.5 g) of the foam was taken and placed on a collagen-coated cell culture petri dish (Sumitomo Bakelite MS-0060) having a diameter of 60 mm. The solution that had flowed down the petri dish was set up vertically so that it would flow out of the petri dish and left for 1 hour. Next, after washing twice with PBS, 5 mL of methanol was added, and the mixture was gently stirred for 10 minutes to extract the oil-soluble component retained on the petri dish. After this extraction operation was repeated three times, oil-soluble components were quantified by liquid chromatography using the following method.

(I) Quantitative method and evaluation criteria for vitamin E or its derivatives Measurement conditions were as follows: methanol was transferred using a column filled with 5 μm octadecylsilylated silica gel for liquid chromatography in a stainless steel tube with an inner diameter of 4.6 mm and a length of 15 cm. It was used for the phase, and was measured by an absolute calibration curve method with ultraviolet absorbance (measurement wavelength: 284 nm) at a column temperature of 25 ° C. and a flow rate of 1.0 mL / min.
Retention amount evaluation of vitamin E or its derivative was evaluated by the amount with respect to the blending amount with respect to the average value of three repetitions.
◎: Residence amount is 20% or more ○: Residence amount is 10% or more and less than 20% △: Residence amount is 5% or more and less than 10% ×: Residence amount is less than 5%

(Ii) Triclosan Quantitative Method and Evaluation Criteria Measurement conditions were as follows: a stainless steel tube having an inner diameter of 4.6 mm and a length of 15 cm filled with 5 μm of octadecylsilylated silica gel for liquid chromatography, acetonitrile / water / acetic acid / =. 60/40/1 was used as a mobile phase, and measurement was performed by an absolute calibration curve method with ultraviolet absorbance (measurement wavelength: 284 nm) at a column temperature of 45 ° C. and a flow rate of 1.0 mL / min.
The evaluation of the retention amount of triclosan was evaluated by the amount with respect to the blending amount with respect to the average value of three times.
◎: Residence amount is 20% or more ○: Residence amount is 10% or more and less than 20% △: Residence amount is 5% or more and less than 10% ×: Residence amount is less than 5%

(Iii) Determination method and evaluation standard of isopropylmethylphenol The measurement conditions were acetonitrile / water / acetic acid using a column filled with 5 μm octadecylsilylated silica gel for liquid chromatography in a stainless tube having an inner diameter of 4.6 mm and a length of 15 cm. / = 60/40/1 was used as a mobile phase, and measurement was performed by an absolute calibration curve method with ultraviolet absorbance (measurement wavelength: 284 nm) at a column temperature of 45 ° C. and a flow rate of 1.0 mL / min.
The retention amount of isopropylmethylphenol was evaluated by an amount relative to the blending amount with respect to an average value of three times.
◎: Residence amount is 20% or more ○: Residence amount is 10% or more and less than 20% △: Residence amount is 5% or more and less than 10% ×: Residence amount is less than 5%

The raw materials used in the following examples are as follows. The fragrance composition is shown in Table 5.
Dl-tocopherol acetate;
DSM Nutrition Japan Co., Ltd., dl-α-tocopherol triclosan acetate; Ciba Specialty Chemicals Co., Ltd. triclosan isopropylmethylphenol; Osaka Kasei Co., Ltd. Biosol Xanthan Gum; Kelco Co., Ltd. Monato Gum DA
Sodium carboxymethylcellulose; CMC1260 manufactured by Daicel Chemical Industries, Ltd.
Sodium lauryl sulfate; manufactured by Toho Chemical Industry Co., Ltd. Sodium lauryl sulfate, myristyl sodium sulfate; manufactured by Nippon Chemicals Co., Ltd. NIKKOL SMS
N-lauroylmethyl taurine sodium;
NIKKOL LMT manufactured by Nippon Chemicals Co., Ltd.
Palm oil fatty acid amidopropyl betaine;
Enadicol C-30B, 30% aqueous solution amidepropylbetaine laurate manufactured by Lion Corporation;
Enigcol L-30B, 30% aqueous coconut oil fatty acid imidazolium betaine manufactured by Lion Corporation;
Enadicol C-40H, 30% aqueous solution lauryldimethylaminoacetate betaine manufactured by Lion Corporation;
AM-301, 35% aqueous solution manufactured by Nikko Chemicals Co., Ltd.

＊１）ヤシ油脂肪酸アミドプロピルベタインは、３０％水溶液を使用し、配合量は純分換算した値を示した（以下、同様。）。
＊２）ソルビット液（７０％）の配合量は、有姿（溶液）としての配合量で示した（以下、同様。）。

* 1) A coconut oil fatty acid amidopropyl betaine used a 30% aqueous solution, and the compounding amount showed a value converted into a pure component (the same applies hereinafter).
* 2) The blending amount of sorbite liquid (70%) is shown as the blending amount as a solid (solution) (the same applies hereinafter).

＊３）ラウリン酸アミドプロピルベタインは、３０％水溶液を使用し、配合量は純分換算した値を示した。
＊４）ヤシ油脂肪酸イミダゾリウムベタインは、３０％水溶液を使用し、配合量は純分換算した値を示した。
＊５）ラウリルジメチルアミノ酢酸ベタインは、３５％水溶液を使用し、配合量は純分換算した値を示した。

* 3) As lauric acid amidopropyl betaine, a 30% aqueous solution was used, and the blending amount showed a value in terms of pure content.
* 4) A coconut oil fatty acid imidazolium betaine used a 30% aqueous solution, and the blending amount showed a value converted into a pure component.
* 5) As for lauryldimethylaminoacetic acid betaine, a 35% aqueous solution was used, and the compounding amount showed a value converted into a pure component.

As can be seen from the results of Tables 1 to 3, when (A) xanthan gum is not included, it is excellent even if it contains (B) and (C) components, regardless of whether other binders are included. The foamy creamy feeling, foam persistence, and absence of foam were not obtained, and the oil-soluble component was poor in retention (Comparative Examples 1 and 2). Moreover, when the compounding quantity of xanthan gum was less than 1.4%, the creamy feeling of foam and the absence of foam were inferior, and the retention of oil-soluble components was inferior (Comparative Examples 3 and 10). When the blending amount of xanthan gum was more than 2.5%, the foamy creamy feeling and the absence of foam dripping were poor, and the foaming and foam persistence were also poor (Comparative Example 4). (B) When the alkyl sulfate is not included, when other anionic surfactant is used instead of the alkyl sulfate, or even when the alkyl sulfate is blended, if the blending amount is less than 1.4%, foaming occurs. Inferiority, foam creamy feeling, retention of oil-soluble components does not improve (Comparative Examples 5 to 7). If the blending amount exceeds 2.5%, foaming increases and sustainability improves, but foam creamy feeling. The lack of bubble dripping was inferior (Comparative Example 8). When the mass ratio of (A) xanthan gum / (B) alkyl sulfate is less than 0.7, the foam is inferior in creamy feeling and lack of bubble dripping, the oil-soluble component is poorly retained, and if it is greater than 1.5, foaming occurs. In addition, the foamy creamy feeling and the persistence of the foam were inferior, and the retention of the oil-soluble component was not improved (Comparative Examples 10 to 12).
Moreover, when (C) the amphoteric surfactant was not blended, foaming was inferior, and the foamy creamy feeling and the absence of bubble dripping were inferior (Comparative Example 9). The reason why the oil-soluble component has good retention in Comparative Example 4 is presumed to be that although the foaming deteriorates, the fluidity of the standing foam is poor, and the retention has occurred.
As described above, in the comparative example, it is not possible to satisfactorily improve the foam feeling and the retention in the mouth of the oil-soluble active ingredient as described above, and particularly, the foam excellent in creamy feeling is sustained, and the foam does not sag. A preparation capable of satisfactorily retaining the oil-soluble active ingredient in the mouth could not be obtained. In contrast, a dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E or a derivative thereof, triclosan, isopropylmethylphenol, (A) xanthan gum and (B) a specific amount of alkyl sulfate, And by blending at a specific ratio and using (C) amphoteric surfactant in combination, it is excellent in foaming, foam creamy feeling, and foam persistence, without dripping, and in the mouth retention of oil-soluble components It was found that the object of the present invention can be achieved.

  Next, a dentifrice composition having the composition shown in Table 4 was prepared in the same manner as described above, and in the same manner as described above, good foaming, foam creaminess, foam persistence, no dripping, and oil-soluble components Mouth retention was evaluated. Further, the effect of removing colored stains on teeth was evaluated by the following method. The results are shown in Table 4.

<Evaluation of tooth stain removal effect>
First, the color of the surface of untreated hydroxyapatite (hereinafter referred to as HAP; manufactured by Pentax Co., Ltd.) was used as a reference color and measured with an equation difference meter, and the value was defined as L0. This HAP was immersed in a saliva for 30 minutes at 37 ° C. and then washed with distilled water. The following three types of immersion liquids (0.5% albumin remineralization solution, 3% Japanese tea + 1) are prepared by remineralization liquid prepared by mixing 0.74 mM calcium ion, 2.59 mM phosphate ion, and 150 mM NaCl. % Coffee + 1% black tea remineralization solution, 0.6% ammonium iron citrate remineralization solution), 0.5% albumin remineralization solution → 3% Japanese tea + 1% coffee + 1 % Black tea remineralization solution → an operation of repeatedly dipping in 0.6% ammonium iron citrate remineralization solution for 1 hour was repeated 50 times. After air-drying at room temperature for 1 day, the color of the colored HAP surface completed by washing with running water and air-drying again was measured with a color difference meter, and the value was defined as L1.

  50 ml of a dentifrice diluted solution obtained by diluting the test dentifrice composition 3 times with water was put in a beaker and stirred until it was uniform, brought to 37 ° C. in a water bath, and sufficiently foamed with a milk foamer. The foamy foam was placed on a colored HAP in which 1 tablespoon (about 1.0 g) was placed so that the colored stain was vertical, and placed at 37 ° C. for 5 minutes. After brushing with a toothbrush 50 times as it is, it was washed with running water and dried, and the color of HAP was measured again with a color difference meter, and the value was taken as L2. The colored stain removal rate was calculated according to the following equation, and the effect of removing the colored stain on the teeth was evaluated according to the following criteria.

Colored stain removal rate (%) = {(L1-L2) / (L1-L0)} × 100
Evaluation criteria ◎: Removal rate of 80% or more ○: Removal rate of 50% or more and less than 80% △: Removal rate of 25% or more and less than 50% ×: Removal rate of less than 25%

The raw materials used in the following examples are as follows. In addition, about the (A), (B), (C) component, the thing similar to what was used above was used. The fragrance composition is shown in Table 5.
Sodium tripolyphosphate; manufactured by Taihei Chemical Industry Co., Ltd. sodium tripolyphosphate anhydrous sodium pyrophosphate; manufactured by Taihei Chemical Industrial Co., Ltd. sodium pyrophosphate anhydrous malic acid; manufactured by Wako Pure Chemical Industries, Ltd. DL-malic acid phytic acid; Tsukino Phytic acid by Food Industry Co., Ltd.

＊６）フィチン酸は、５０％水溶液を使用し、配合量は純分換算した値を示した。

* 6) As for phytic acid, a 50% aqueous solution was used, and the blending amount showed a value in terms of pure content.

  From the results of Table 4, in addition to the components (A) to (C), and further (D) a chelating agent, good foaming, foamy creaminess, foam persistence, no drooling, and oil In addition to the good retention of the soluble component in the mouth, it was found that (D) the retention of the chelating agent on the tooth surface was improved and the effect of removing colored stains on the teeth was excellent.

表中、部は質量部である（以下、同様。）。

In the table, parts are parts by mass (the same applies hereinafter).

  Next, a dentifrice composition having the following composition was prepared by a conventional method and evaluated in the same manner as described above, all of which were excellent in foaming, foam creaminess, foam persistence, and no dripping, and oil It was excellent in the retention of soluble components in the mouth and excellent in the removal of colored stains on teeth.

Example 34
Dl-tocopherol acetate 0.1
(Component A) xanthan gum 1.6
(B component) Sodium lauryl sulfate 1.6
(Component C) Palm oil fatty acid amidopropyl betaine 0.3
(Component D) Sodium tripolyphosphate 1
Propylene glycol 3
Sodium polyacrylate 0.2
Sodium alginate 0.1
Abrasive silica 15
Sorbit liquid (70%) 35
Sodium fluoride 0.2
Epsilon-aminocaproic acid 0.05
Anhydrous sodium sulfate 0.3
Fragrance B 1
Purified water balance
Total 100.0%
(A component) / (B component) = 1.0

Example 35
Dl-Tocopherol acetate 0.03
Isopropylmethylphenol 0.03
(Component A) xanthan gum 1.4
(B component) Sodium lauryl sulfate 1.8
(C component) Palm oil fatty acid imidazolium betaine 0.5
(Component D) anhydrous sodium pyrophosphate 0.5
Propylene glycol 3
Sodium carboxymethylcellulose 0.2
Anhydrous calcium phosphate 20
Sorbit liquid (70%) 25
Sodium monofluorophosphate 0.7
Fragrance B 1
Purified water balance
Total 100.0%
(Component A) / (Component B) = 0.78

Example 36
Isopropylmethylphenol 0.1
(Component A) xanthan gum 1.8
(B component) Sodium lauryl sulfate 1.4
(C component) Palm oil fatty acid amidopropyl betaine 1
(D component) Malic acid 2
Propylene glycol 3
Calcium carbonate 25
Sorbit liquid (70%) 25
Sodium monofluorophosphate 0.7
Fragrance B 1
Purified water balance
Total 100.0%
(Component A) / (Component B) = 1.29

Claims (6)

A dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E and its derivatives, triclosan, isopropylmethylphenol, (A) 1.4 to 2.5% by mass of xanthan gum and (B) alkyl sulfate 1 .4 to 2.5% by mass with (A) / (B) mass ratio of 0.7 to 1.5, and (C) 0.05 to 1.5 % by mass of amphoteric surfactant. A dentifrice composition characterized by the above.   (C) The dentifrice according to claim 1, wherein the amphoteric surfactant is at least one selected from alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine. Composition. Furthermore, the dentifrice composition of Claim 1 or 2 which mix | blended 0.1-5 mass% of (D) chelating agents. The dentifrice composition according to claim 3 , wherein the component (D) is one or more selected from linear polyphosphate, malic acid, and phytic acid. The dentifrice composition according to any one of claims 1 to 4, which is a toothpaste composition. A dentifrice composition containing one or more oil-soluble ingredients selected from vitamin E and its derivatives, triclosan, isopropylmethylphenol, (A) 1.4 to 2.5% by mass of xanthan gum and (B) alkyl sulfate 1 .4 to 2.5% by mass with (A) / (B) mass ratio of 0.7 to 1.5, and (C) 0.05 to 1.5 % by mass of amphoteric surfactant. A method for improving the foam performance of the dentifrice composition and the retention in the mouth of the oil-soluble component.