JPWO2016136719A1 - Dentifrice composition - Google Patents

Abstract

One or more selected from (A) a copper salt and a zinc salt, which has an excellent halitosis suppression effect, and has a rough surface on the preparation surface over time, liquid separation is suppressed and appearance stability is excellent, and is suitable for prevention or suppression of bad breath. The water-soluble metal salt was 0.01 to 1% by mass, and (B) the viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer was 10 mPa · s or more, and measured with the viscometer. A dentifrice composition comprising 0.01 to 0.5% by mass of a highly polymerized polyethylene glycol having a viscosity of a 2 W / V% aqueous solution at 25 ° C. of 800 mPa · s or less is provided.

Description

  The present invention relates to a dentifrice composition containing a water-soluble metal salt, which has an excellent halitosis suppression effect and is excellent in appearance stability due to suppressed skin roughness and liquid separation over time, and is suitable for prevention or suppression of halitosis.

  Conventionally, metal salts such as copper salts and zinc salts are said to have an effect of preventing bad breath, and proposals for application to oral compositions have been made (Patent Document 1; Japanese Patent Laid-Open No. 01-153622). ). However, when the above metal salt is blended in the dentifrice composition, there is a drawback that the bad breath removal effect is not sufficiently exhibited over time due to reaction or adsorption with abrasives such as calcium hydrogen phosphate and calcium carbonate. Patent Document 2 (Japanese Patent Laid-Open No. 02-311413) proposes a technique that improves the deodorization rate of methyl mercaptan by using modified aluminum hydroxide and improves the bad breath prevention effect.

  On the other hand, in the field of oral care, polyethylene glycol is used as a humectant or a thickener. However, there are few examples of blending highly polymerized polyethylene glycol having a molecular weight of 100,000 or more in the preparation, and examples of using it for improving the foaming performance of liquid dentifrices (Patent Document 3: JP-T-2006-506359), Example used for dentifrice with excellent remineralization promoting effect (Patent Document 4: Japanese Patent Laid-Open No. 2013-112613), foaming during dentifrice by blending highly polymerized polyethylene glycol, alkyl sulfate and thickening silica It is a grade where the example (patent document 5: international publication 2010/073975) which improved the property and the persistence of foam was disclosed.

Japanese Patent Laid-Open No. 01-153622 Japanese Patent Laid-Open No. 02-311413 JP 2006-506359 A JP 2013-112613 A International Publication No. 2010/073975

  However, it is difficult to say that the dentifrice composition containing the above metal salt has a sufficient bad breath prevention effect, and it has been desired to develop a preparation that can improve the bad breath suppression effect and can be used more effectively for bad breath prevention.

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition containing a water-soluble metal salt that has an excellent halitosis suppression effect and is excellent in appearance stability due to suppression of rough skin and liquid separation over time. For the purpose.

  As a result of intensive studies to achieve the above object, the present inventor has (A) 0.01-1% by mass of a water-soluble metal salt selected from a copper salt and a zinc salt, and (B) a Brookfield viscosity. Highly-polymerized polyethylene glycol having a 5 W / V% aqueous solution viscosity at 25 ° C. measured by a meter of 10 mPa · s or more and a 2 W / V% aqueous solution viscosity at 25 ° C. measured by the viscometer of 800 mPa · s or less. When combined with 0.01 to 0.5% by weight, the bad breath suppression effect is improved, and the surface of the dentifrice preparation over time and liquid separation are suppressed, and good appearance stability can be provided. I found it. That is, according to the present invention, by appropriately blending the component (B) into the dentifrice composition containing the component (A), the bad breath suppression effect is high and the appearance stability is excellent, or the prevention of bad breath or The inventors have found that a dentifrice composition suitable for suppression can be obtained, and have made the present invention.

That is, the bad breath suppression effect of water-soluble metal salts such as copper salts and zinc salts is not sufficient, and even though highly polymerized polyethylene glycol does not have a bad breath suppression effect, By using (B) component together, the bad breath suppression effect derived from (A) component improves, and the external appearance of a formulation is stabilized. In this case, in the dentifrice composition, if the component (A) is used in an inappropriate amount in combination with the component (A), the surface of the preparation becomes rough over time, the texture of the dentifrice becomes poor, liquid separation occurs, and the appearance is stable. However, when the components (A) and (B) are appropriately combined, the problem described above is unexpectedly solved and the effect of suppressing bad breath is enhanced without deteriorating the appearance of the preparation. The effect of suppressing bad breath that has been sufficiently suppressed is not recognized, and the appearance of the preparation is stabilized with time. Therefore, it is possible to provide a smooth and glossy surface, improve the texture of the dentifrice, and further suppress liquid separation.
In the present invention, the effect of suppressing bad breath and appearance stability of the dentifrice composition containing component (A) is improved by the highly polymerized polyethylene glycol of component (B). The use of polyethylene glycol as an agent cannot be predicted.

Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) 0.01 to 1% by mass of one or more water-soluble metal salts selected from copper salts and zinc salts;
(B) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s. A dentifrice composition comprising 0.01 to 0.5% by mass of the following highly polymerized polyethylene glycol.
[2]
The water-soluble metal salt of component (A) is one or more selected from copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, zinc sulfate and zinc citrate [1] The dentifrice composition described.
[3]
The dentifrice composition according to [1] or [2], wherein the water-soluble metal salt of component (A) is copper gluconate and / or zinc citrate.
[4]
The highly polymerized polyethylene glycol of component (B) is the following (1) or (2)
(1) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 to 20,000 mPa · s,
(2) When the viscosity exceeds 20,000 mPa · s in (1), the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s or less [1], [2 ] Or the dentifrice composition according to [3].
[5]
(A) / (B) which shows the ratio of the compounding quantity of (A) component and (B) component is 0.02-100 as mass ratio, The dentifrice in any one of [4] Agent composition.
[6]
The dentifrice composition according to any one of [1] to [5], which is a toothpaste.

  ADVANTAGE OF THE INVENTION According to the present invention, a dentifrice containing a water-soluble metal salt that is excellent in halitosis suppression effects, rough on the surface of the preparation over time, liquid separation is suppressed, has excellent appearance stability, and can be suitably used for prevention or suppression of halitosis A composition can be provided.

  The present invention will be described in detail below. The dentifrice composition of the present invention has (A) a water-soluble metal salt selected from a copper salt and a zinc salt, and (B) a viscosity of 10 mPa · s of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer. It is blended with highly polymerized polyethylene glycol which is not less than s and the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is not more than 800 mPa · s.

  The water-soluble metal salt of component (A) is one or more selected from water-soluble copper salts and zinc salts, such as copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, Zinc sulfate, zinc citrate and the like can be mentioned, and not only anhydrides but also hydrates containing crystal water such as copper sulfate pentahydrate can be used, among which copper gluconate, copper citrate, zinc citrate In particular, copper gluconate and zinc citrate are preferred.

The blending amount of the water-soluble metal salt is 0.01 to 1% (mass%, hereinafter the same) of the whole composition from the viewpoint of suppressing bad breath, preferably 0.01 to 0.5%, more preferably. Is 0.05 to 0.3%. When 0.01% or more is blended, a sufficient halitosis suppression effect is obtained. 1% or less is suitable for preventing the dentifrice from becoming worse over time.
In addition, in the range of the said compounding quantity, the compounding quantity of the water-soluble copper salt of (A) component is 0.0014 to 0.5% of the whole composition as copper, and 0.007 to 0.15% is especially preferable. . Moreover, the compounding quantity of water-soluble zinc salt is 0.0014 to 0.5% of the whole composition as zinc, and 0.007 to 0.15% is especially preferable.

The highly polymerized polyethylene glycol (B) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (capacity))% aqueous solution at 25 ° C. measured with a Brookfield viscometer. The viscosity is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s or less.
When the viscosity of the 5 W / V% aqueous solution exceeds 20,000 mPa · s, the viscosity cannot be measured, so the viscosity in the 2 W / V% aqueous solution is adopted. That is, in the present invention, highly polymerized polyethylene glycol has the following viscosity physical properties (1) or (2).
(1) The viscosity of a 5 W / V% aqueous solution at 25 ° C. is 10 to 20,000 mPa · s.
(2) In (1), when the viscosity exceeds 20,000 mPa · s, the viscosity of the 2 W / V% aqueous solution at 25 ° C. is 800 mPa · s or less. In the present invention, more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C. The viscosity of the / V% aqueous solution is 10 to 18,000 mPa · s, particularly 30 to 10,000 mPa · s, especially 55 to 2,000 mPa · s, more particularly 55 to 250 mPa · s.
In the present invention, by using highly polymerized polyethylene glycol having a viscosity within the above specific range as component (B), the effect of suppressing bad breath derived from component (A) is improved, and the roughness of the preparation surface over time is improved. Liquid separation is suppressed, and good appearance stability is given.
If the viscosity of the 5 W / V% aqueous solution is less than 10 mPa · s, the effect of improving the texture of the dentifrice cannot be sufficiently obtained, and if the viscosity of the 2 W / V% aqueous solution exceeds 800 mPa · s, The texture decreases with time.

As the highly polymerized polyethylene glycol of component (B), the following commercially available products can be used.
・ POLYOX WSR N-10
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 12-50 mPa · s, measuring equipment: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes)
・ POLYOX WSR N-80
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 55 to 115 mPa · s, measuring equipment: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes)
・ POLYOX WSR N-750
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 1,000 to 1,200 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 10 rpm, measuring temperature 25 ° C., measuring time 1 minute )
・ POLYOX WSR-205
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 4,500-8,800 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR-1105
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 8,800-17,600 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR N-12K
(Manufactured by Dow Chemical Co., Ltd., viscosity of 2 W / V% aqueous solution: 400 to 800 mPa · s, measuring equipment: Brookfield RVF, rotor No. 1, rotation speed 10 rpm, measuring temperature 25 ° C., measuring time 1 minute)

  (B) The compounding quantity of the highly polymerized polyethylene glycol of a component is 0.01 to 0.5% of the whole composition, Preferably it is 0.03 to 0.2%, More preferably, it is 0.05 to 0.1 %. If the blending amount is less than 0.01%, a sufficient bad breath suppressing effect and a dentifrice improving effect cannot be obtained. If the amount is too large, further improvement in the effect cannot be expected, and the appearance stability of the preparation decreases, and if it exceeds 0.5%, the texture of the dentifrice cannot be maintained well and liquid separation can be suppressed. Can not.

In this invention, when (A) component and (B) component are mix | blended in an appropriate ratio, the bad breath suppression effect will be more excellent and external appearance stability will also improve more. In this case, (A) / (B) indicating the ratio of the blending amount of the component (A) and the component (B) is preferably 0.02 to 100, more preferably 0.1 to 10, particularly preferably the mass ratio. Is 0.5-6, more preferably 0.5-2. If the (A) / (B) ratio is too small, the bad breath suppression effect may not be obtained sufficiently. If it is too large, the texture of the dentifrice will not be improved sufficiently, or liquid separation will not be sufficiently suppressed. There is a case.
In addition, in the mass ratio of (A) / (B), the ratio of the blending amount of the water-soluble copper salt of the component (A) as copper and the blending amount of the component (B) is shown (A-1 ) / (B) is preferably 0.003 to 50, and particularly preferably 0.07 to 3 as a mass ratio. Moreover, (A-2) / (B) which shows the ratio of the compounding quantity as zinc of the water-soluble zinc salt of (A) component and the compounding quantity of (B) component is 0.003-50 as mass ratio, especially 0.07-3 is preferable.

When the (C) alginate propylene glycol ester is further blended with the dentifrice composition of the present invention, the sustainability of the halitosis suppression effect is improved, and the metallic taste derived from the component (A) is preferably suppressed. The propylene glycol alginate to be used is not particularly limited, but the viscosity of a 1% aqueous solution (20 ° C.) by a Brookfield viscometer is in the range of 10 to 1,300 mPa · s, particularly 10 to 200 mPa · s. preferable.
(C) 0.01 to 3% of the whole composition is preferable, and, as for the compounding quantity of propylene glycol alginate, 0.05 to 3% is more preferable. Within the above range, the bad breath suppression sustaining effect is particularly excellent, and the metallic taste is suppressed and the feeling of use is also good.
Moreover, it is preferable that the mixture ratio of (A) component with respect to (C) propylene glycol alginate is 0.01-5 by mass ratio.

  The dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice, and the like, particularly as a toothpaste. Moreover, the well-known component normally used besides the said component can be mix | blended as needed according to the dosage form. For example, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, colorants, fragrances, active ingredients other than the above, and the like are used in normal amounts within a range that does not interfere with the effects of the present invention. Can do.

  Examples of the abrasive include silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based abrasives such as dicalcium phosphate, aluminum hydroxide, alumina, calcium carbonate, synthetic resin-based abrasives, etc. It is done. The blending amount of the abrasive is usually 5 to 50%.

  Examples of the thickener include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as glycerin and propylene glycol. The amount of these thickeners is usually 5 to 50%.

  Examples of the binder include cellulose derivatives such as sodium carboxymethyl cellulose, gums such as xanthan gum, and the like. The amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate. Examples of nonionic surfactants include polyhydric acids such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sugar alcohol fatty acid esters such as sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene glycerin fatty acid esters. Examples include alcohol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and fatty acid alkanolamides.
Examples of the cationic surfactant include alkylammonium type, and examples of the amphoteric surfactant include betaine type and imidazoline type.
The blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.

  Examples of the sweetening agent include saccharin sodium. Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, benzoic acid or a salt thereof. Examples of the colorant include blue No. 1, yellow No. 4, and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, and dentifrice composition It can be used in combination with known perfume materials used in the above. The blending amount of these fragrances is usually 0.00001 to 3%.

  As the active ingredient, known ingredients that are usually blended in dentifrice compositions can be used. For example, fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anticalculus agents, antiplaque agents, etc. can be blended. . Specifically, fluorides such as sodium fluoride and sodium monofluorophosphate, nonionic fungicides such as isopropylmethylphenol, cationic fungicides, enzyme tranexamic acids such as dextranase, epsilon aminocaproic acid, allantoin, etc. Anti-inflammatory agents and the like. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1-3.

(1) Evaluation method of halitosis suppression effect Five volunteers who had halitosis and were not taking antibiotics within one month were subjects. Subjects were prohibited from oral cleaning and eating and drinking from the night before the test day. The breath odor test involves collecting the bad breath before the start of the test and 1 hour after brushing the teeth (after the test) in a Tedora bag. Judgment according to
<Scoring criteria for bad breath intensity>
0 points: No bad breath is observed 1 point: A slight bad breath is observed 2 points: Bad breath is observed 3 points: Remarkable bad breath is observed Further, the degree of improvement of bad breath is obtained by the following formula, and the bad breath of the test composition is suppressed The effect was evaluated according to the following criteria.
<Calculation formula of bad breath improvement>
(Degree of bad breath improvement) = (Average value of bad breath before test start)-(Average bad breath intensity after test)
In addition, a bad breath intensity average value is the value which averaged the bad breath intensity of the test subject of each group.
<Evaluation criteria for bad breath suppression effect>
A: There is a remarkable effect. Improvement in halitosis is 1.5 points or more. Bad breath improvement degree is 1.0 point or more and less than 1.5 point Δ: Some effect. Bad breath improvement degree of 0.5 point or more and less than 1.0 point ×: No effect. Bad breath improvement is less than 0.5 points

(2) Method for evaluating the roughness of the preparation surface (texture of the dentifrice) After 1 month storage at 50 ° C., the appearance of the kneaded product when the dentifrice composition is taken out from the tube to the toothbrush (the roughness of the preparation surface ( About the dentifrice texture)), the three evaluators determined the following scoring criteria.
Grade criteria 5: Wrinkles are not recognized, smooth and glossy 4: Wrinkles are not recognized 3: Wrinkles are slightly recognized, but there is no problem in quality 2: Wrinkles are recognized, No granular aggregates are observed 1: Wrinkles and granular aggregates are considerably observed. The average score of three persons was determined, and the texture of the dentifrice was evaluated according to the following criteria.
Evaluation criteria ◎: Average score is 4.5 or higher ○: Average score is 3.0 or higher and lower than 4.5 △: Average score is 2.0 or higher and lower than 3.0 ×: Average score is 2.0 Less than

(3) Evaluation Method of No Liquid Separation After storage for 1 month at 50 ° C., three evaluators determined the liquid separation when the dentifrice composition was taken out from the tube to the toothbrush according to the following criteria.
Rating criteria 5: No separation of liquid is observed 4: Slight bleeding is observed at the mouth, but overall there is no problem 3: Overall, slight bleeding is observed, but there is no problem with quality 2: Separation of liquid is observed in the whole 1: Vigorous liquid separation enough to fall from the toothbrush is observed. The average score of three persons was determined, and the absence of liquid separation was evaluated according to the following criteria.
Evaluation criteria ◎: Average score is 4.5 or higher ○: Average score is 3.0 or higher and lower than 4.5 △: Average score is 2.0 or higher and lower than 3.0 ×: Average score is 2.0 Less than

Details of the raw materials used are shown below. The viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured with a Brookfield viscometer (Brookfield RVT or RVF), as described above. Moreover, the viscosity of polyethylene glycol # 400 measured by the same method was less than the viscosity of (B) highly polymerized polyethylene glycol.
(A) Copper gluconate; manufactured by Kanto Chemical Co., Ltd., copper gluconate (A) zinc citrate; manufactured by Kanto Chemical Co., Inc., zinc citrate (B) highly polymerized polyethylene glycol;
POLYOX WSR N-80
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 85 mPa · s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes))
POLYOX WSR N-10
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 35 mPa · s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes))
POLYOX WSR N-750
(Dow Chemical Co., Viscosity of 5 W / V% aqueous solution: 1,100 mPa · s
(Rotor No. 2, rotation speed 10 rpm, measurement time 1 minute))
POLYOX WSR N-12K
(Manufactured by Dow Chemical Co., Ltd., viscosity of 2 W / V% aqueous solution: 420 mPa · s (rotor No. 1, rotation speed 10 rpm, measurement time 1 minute))
Polyethylene glycol # 400
(Average molecular weight 380 described in Sanyo Chemical Industries, Ltd., Quasi-drug raw material standard 2006)
~ 420)

  Next, a dentifrice composition (toothpaste) having the composition shown in Table 4 was prepared by a conventional method using the same raw materials as described above, and evaluated by the same method. Moreover, the sustainability of the bad breath suppression effect (bad breath suppression continuous effect) and the metallic taste suppression effect were evaluated by the following methods. The results are also shown in Table 4.

(4) Method of evaluating bad breath suppression effect According to the method of evaluation of bad breath suppression, brushing teeth after the test, collecting bad breath after 4 hours, determining bad breath strength, and further improving bad breath The bad breath suppression effect was evaluated.

(5) Evaluation Method of Metallic Taste Suppressing Effect Using 10 subjects, about 1 g of the dentifrice composition was put on a toothbrush and the toothpaste was brushed for 3 minutes. Evaluation was made with 3 points for feeling taste, 2 points for feeling metallic taste, and 1 point for feeling very metallic taste.
The metal taste suppression effect was evaluated from the average score of 10 people according to the following criteria.
Evaluation criteria for metallic taste suppression effect:
◎: Average point is 3.5 or more and less than 4.0 point ○: Average point is 3.0 or more and less than 3.5 point Δ: Average point is 2.0 or more and less than 3.0 point ×: Average point is 1.0 to less than 2.0

＊１：商品名「キミロイドＢＦ」、（株）キミカ製、
１％水溶液（２０℃）の粘度：２０ｍＰａ・ｓ（ＢＬ型粘度計、ロー
ターＮｏ．１、回転数６０ｒｐｍ）

* 1: Product name “Kimiloid BF”, manufactured by Kimika Co., Ltd.
Viscosity of 1% aqueous solution (20 ° C.): 20 mPa · s (BL viscometer, rotor No. 1, rotation speed 60 rpm)

[Prescription example]
Hereinafter, Table 5 shows formulation examples. The dentifrice compositions of the formulation examples were prepared in the same manner as described above and evaluated in the same manner. As a result, the bad breath suppressing effect, the texture of the dentifrice, and the absence of liquid separation were all excellent.

Claims (6)

(A) 0.01 to 1% by mass of one or more water-soluble metal salts selected from copper salts and zinc salts;
(B) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s. A dentifrice composition comprising 0.01 to 0.5% by mass of the following highly polymerized polyethylene glycol.   The water-soluble metal salt of component (A) is one or more selected from copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, zinc sulfate and zinc citrate. Dentifrice composition.   The dentifrice composition according to claim 1 or 2, wherein the water-soluble metal salt of component (A) is copper gluconate and / or zinc citrate. The highly polymerized polyethylene glycol of component (B) is the following (1) or (2)
(1) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 to 20,000 mPa · s,
(2) When the viscosity exceeds 20,000 mPa · s in (1), the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s or less. 3. The dentifrice composition according to 3.   (A) / (B) which shows the ratio of the compounding quantity of (A) component and (B) component is 0.02-100 as mass ratio, The dentifrice of any one of Claims 1-4 Composition.   The dentifrice composition according to any one of claims 1 to 5, which is a toothpaste.