JP6269672B2 - Oral biofilm remover and oral composition - Google Patents

Description

  The present invention relates to an oral biofilm remover and an oral composition having a high effect of chemically removing a biofilm that causes caries.

Conventionally, plaque removal technology in dentifrice includes physical removal with a cleaning agent such as an abrasive and biochemical removal with an enzyme.
When removing with a cleaning agent, it is necessary to increase the amount of abrasive or increase hardness in order to exert its effect, but with this, the polishing power increases, causing damage and irritation due to damage to teeth and gums. It could be easier. On the other hand, in order to stably mix the enzyme, various stabilizers must be used in combination, which may affect the feeling of use such as foaming and taste.

  In recent years, if plaque is regarded as a biofilm and the biofilm can be removed, the plaque can be more effectively removed. In order to remove the biofilm in the oral cavity, not only a physical method by brushing using a toothbrush but also a chemical method capable of removing a biofilm that does not reach the brush is useful. Biofilms are composed of various oral bacterial coaggregates and extracellular polysaccharides. Therefore, as chemical removal methods, it is known to use erythritol, which has a coaggregation-inhibiting action, and proteases such as enzymes that degrade exopolysaccharides, dextranases, and mutanases. There was room.

  In addition, surfactants are known to have a cleaning action, and are used in oral compositions as cleaning agents. In this case, sodium lauryl sulfoacetate is known as an activator having no irritation peculiar to an anionic surfactant (Patent Document 1: JP-A-6-72836).

  Conventionally, however, surfactants have been recognized as having a slight plaque removal effect in terms of their penetrating action and interfacial cleaning action, but sufficient use of a surfactant alone is sufficient. The current situation is that the biofilm removal effect is not recognized.

  Patent Document 2 (Japanese Patent Publication No. 2008-519043) discloses that an alkali metal salt or ammonium salt of alkyl sulfoacetate is used in combination with a water-soluble zinc salt. It is used to reduce the astringency of salt, and no biofilm removal effect is shown. Furthermore, Patent Document 3 (Japanese Patent Laid-Open No. 9-508120) discloses a toothpaste containing sodium lauryl sulfoacetate as an oral composition with reduced irritation to the oral mucosa. Not mentioned.

  On the other hand, it is known that condensed phosphate has a chemical tooth dirt removing effect (Patent Document 4: Japanese Patent Laid-Open No. 9-175966). It is not recognized as having a film removal effect.

JP-A-6-72836 Special table 2008-519043 gazette JP-A-9-508120 JP 9-175966 A

  This invention is made | formed in view of the said situation, and makes it a subject to provide the oral biofilm removal agent and composition for oral cavity with the high effect which removes the biofilm which causes a dental caries chemically.

In the present invention, as a result of intensive studies to achieve the above-mentioned problems of the present invention, (A) alkyl sulfoacetate, and (B) condensed phosphate (B-1) and / or amphoteric surfactant (B It was found that the above problem can be solved by using -2) together.
Specifically, the present inventors have significantly improved the removal effect of the oral biofilm by combining (A) alkyl sulfoacetate and (B) condensed phosphate (B-1). And it discovered that the bitterness peculiar to (A) component can be suppressed and moderate foaming can be provided (Invention I).
In the first invention, the component (A) and the component (B-1) are specifically and synergistically, particularly within a range of 0.1 to 10 (A) / (B-1) as a mass ratio. Acts and enhances the action of dispersing and removing the oral biofilm. Moreover, the bitterness derived from (A) component can be suppressed and moderate foaming by (A) component can be given.

  That is, as shown in Examples and Comparative Examples described later, when the alkylsulfoacetate as the component (A) is used alone, the removal rate of the produced biofilm is less than 70%. Moreover, although the biofilm removal rate in condensed phosphate (B-1) is less than 50%, and there is not sufficient biofilm removal effect, (A) component and (B-1) component Surprisingly, it was found that both components act synergistically and a sufficient biofilm removal effect is obtained. In this case, an anionic surfactant other than the component (A), such as sodium lauryl sulfate and condensed phosphate, cannot be used to obtain a sufficient biofilm removal effect. It has been found that this is a specific effect when the component (A) and the component (B-1) are used in combination. Furthermore, although alkyl sulfoacetate has a strong bitter taste and its use has been disclosed in the literature in the past, its use was actually avoided in oral preparations. When used in combination with the component (B-1), the bitterness derived from the component (A) is suppressed, a good feeling of use is given, and moderate foaming due to the component (A) is maintained, which is suitable for actual use. As a result, the present invention has been made.

In addition, as a result of intensive studies to solve the above-described problems of the present invention, the present inventors have combined (A) alkyl sulfoacetate and (B) amphoteric surfactant (B-2). It has been found that the removal effect of the oral biofilm is remarkably improved, that the bitterness peculiar to the component (A) can be suppressed, and that appropriate foaming can be imparted (Invention II).
In the II invention, the component (A) and the component (B-2) are specifically and synergistically, particularly within a range of 0.2 to 8 (A) / (B-2) as a mass ratio. Acts and enhances the action of dispersing and removing the oral biofilm. Moreover, the bitterness derived from (A) component can be suppressed and moderate foaming by (A) component can be given.

  That is, as shown in Examples and Comparative Examples described later, when the alkylsulfoacetate as the component (A) is used alone, the removal rate of the produced biofilm is less than 70%. Moreover, the biofilm removal rate in the amphoteric surfactant (B-2) is less than 50%, and there is no sufficient biofilm removal effect. Even if this is used in combination with other surfactants, the biofilm is removed. Although it is not considered to improve the effect, when the component (A) and the component (B-2) are used in combination, both components unexpectedly act synergistically, and the surfactant system is sufficient. It was found that a biofilm removal effect can be obtained. In this case, an anionic surfactant other than the component (A), for example, sodium lauryl sulfate in combination with an amphoteric surfactant, a sufficient biofilm removal effect cannot be obtained. It has been found that this is a specific effect when the component (A) and the component (B-2) are used in combination. Furthermore, although the alkyl sulfoacetate has a bitter taste and its use has been disclosed in the literature in the past, its use was actually avoided, but the component (A) and (B- 2) When used in combination with component, the bitterness derived from component (A) is suppressed, giving a good feeling of use, and maintaining appropriate foaming due to component (A), making it a preparation suitable for actual use. As a result, the inventors have made the present invention.

In the II invention, when (C) a quaternary ammonium salt, (D) xylitol and / or erythritol is further blended, a more excellent oral biofilm removing effect can be given.
In this case, a dentifrice composition containing (A) component, (B-2) component, more preferably (C) component, or (A) component, (B-2) component, more preferably (D). It is more preferable that it is a mouthwash composition containing a component.

Accordingly, the present invention (Invention I) provides the following oral biofilm remover and oral composition.
[I-1] An oral biofilm comprising (A) an alkyl sulfoacetate salt and (B-1) a condensed phosphate, wherein (A) / (B-1) is 0.1 to 10 as a mass ratio. Remover.
[I-2] The oral biofilm remover according to [I-1], wherein the alkyl sulfoacetate as the component (A) is lauryl sulfoacetate.
[I-3] (A) 0.3 to 5% by mass of alkylsulfoacetate and (B) 0.1 to 5% by mass of sodium tripolyphosphate (B- 1 ′) , (A) / (B- 1 ' ) is 0.1-10 as mass ratio, The composition for oral cavity characterized by the above-mentioned .
[I- 4 ]
The composition for oral cavity according to [I-3] , which is a dentifrice composition or a mouthwash composition.
[I- 5 ] The composition for oral cavity according to [I-3] or [I- 4], which is used for removing an oral biofilm.

Accordingly, the present invention (No. II invention), provides oral biofilm removal agents described below.
[II-1] An oral biofilm comprising (A) an alkyl sulfoacetate salt and (B-2) an amphoteric surfactant, wherein (A) / (B-2) is 0.2 to 8 as a mass ratio. Remover.
[II-2] The amphoteric surfactant (B-2) is one or more betaine-based amphoteric surfactants selected from fatty acid amide alkylbetaines, imidazolinium betaines and aminoacetic acid betaines. [II-1] The oral biofilm remover as described.
[II-3] The oral biofilm remover according to [II-1] or [II-2], wherein the alkyl sulfoacetate of component (A) is lauryl sulfoacetate .
[II- 4 ] The oral biofilm remover according to any one of [II-1] to [II- 3 ], further comprising (D) xylitol and / or erythritol .

  The oral biofilm remover and oral composition of the present invention are excellent in the chemical removal effect of oral biofilm that causes caries. In addition, bitterness is suppressed, a good feeling of use is given, and moderate foaming is given.

  The present invention will be described in further detail below. The present invention is an oral biofilm remover comprising (A) an alkylsulfoacetate and (B) a condensed phosphate (B-1) and / or an amphoteric surfactant (B-2). Moreover, this invention is a composition for oral cavity containing the said (A) and (B) component.

In the present invention, the invention I is characterized in that (A) an alkyl sulfoacetate and (B) a condensed phosphate (B-1) are used in combination.
(A) Alkylsulfoacetate and component (B-1) can be used in combination to significantly improve the biofilm dispersion and removal, and the bitterness of component (A) can be suppressed and foamability can be moderately imparted. You can also

  (A) Alkyl sulfoacetate can be an alkali metal salt of alkyl sulfoacetate having 10 to 20 carbon atoms, such as sodium or potassium, preferably lauryl sulfoacetate. It is possible to obtain commercial products that can be used for oral preparations.

When the combined phosphate (B-1) of the component (B) used in the first invention is used in combination with the component (A), the biofilm removing effect is improved, the bitterness is suppressed, and appropriate foaming properties are imparted.
As the condensed phosphate of the component (B), the following general formula (1)
M _{n + 2} P _n O _{3n + 1} (1)
(In the formula, M represents Na or K, and n ≧ 2.)
The linear water-soluble polyphosphate shown by these can be used. For example, sodium pyrophosphate or potassium pyrophosphate having a polymerization degree n = 2, sodium tripolyphosphate or potassium tripolyphosphate having n = 3, sodium tetrapolyphosphate or potassium tetrapolyphosphate having n = 4, sodium pentapolyphosphate having n = 5 Furthermore, sodium metaphosphate with high polymerization degree, potassium metaphosphate, etc. are mentioned. These can be used singly or in combination of two or more. Among them, sodium pyrophosphate, potassium pyrophosphate, and sodium tripolyphosphate are more preferable in terms of effect, and sodium tripolyphosphate is particularly preferable. preferable.

  Specifically, sodium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., manufactured by Tohoku Chemical Co., Ltd.), potassium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., manufactured by Toagosei Co., Ltd.), sodium tripolyphosphate ( Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.), potassium tripolyphosphate (Taihei Chemical Sangyo Co., Ltd.), sodium tetrapolyphosphate (Taihei Chemical Sangyo Co., Ltd.), Sodium pentapolyphosphate (manufactured by Taihei Chemical Industry Co., Ltd.) can be used.

In 1st invention, the oral-biofilm removal effect is more excellent in the compounding ratio of (A) component and (B-1) component being a specific range. In this case, the (A) / (B-1) ratio is preferably 0.1 to 10, particularly preferably 0.2 to 8, more preferably 0.2 to 5, even more preferably 0 as a mass ratio. .3-4, particularly preferably 0.6-3.3, particularly preferably 1.2-3.
Within the above ratio range, the biofilm removal effect is more excellent. Moreover, in order to suppress bitterness and give good foaming, the ratio value is desirably 10 or less.

In the present invention, the II invention is characterized in that (A) an alkyl sulfoacetate and (B) the amphoteric surfactant (B-2) are used in combination.
(A) Alkylsulfoacetate and component (B-2) can be used in combination to significantly improve the biofilm dispersion and removal, and the bitterness of component (A) can be suppressed, and foaming can be imparted moderately. You can also

  In this case, the component (A) is the same as in the first invention.

The amphoteric surfactant (B-2) of the component (B) used in the II invention is used in combination with the component (A) to significantly improve the dispersion removal effect of the oral biofilm and suppress bitterness. Gives moderate foaming.
As the amphoteric surfactant, betaines such as fatty acid amide alkylbetaines, imidazolinium betaines and aminoacetic acid betaines can be used. Among these, fatty acid amide alkyl betaines having 8 to 18 carbon atoms in the fatty acid and 1 to 5 carbon atoms in the alkyl group are preferable, and fatty acid amide propyl betaine is more preferable. As such fatty acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine described in Sotohara (a quasi-drug raw material standard) can be used.
As the amphoteric surfactant, commercially available products that can be used in oral preparations can be obtained. Specifically, as the coconut oil fatty acid amidopropyl betaine, a commercially available trade name TEGO Betaine CK OK (manufactured by EVONIK) can be mentioned.

  In the II invention, when the blending ratio of the component (A) and the component (B-2) is in a specific range, the oral biofilm removal effect is more excellent. In this case, the ratio (A) / (B-2) is preferably 0.2 to 8, more preferably 0.4 to 5, still more preferably 0.4 to 4, and particularly preferably 0. .5 to 3.1. Within the above ratio range, the biofilm removal effect is more excellent. Moreover, it is desirable that it is 8 or less in order to give better foaming and to further suppress bitterness.

In the present invention, particularly the II invention, it is preferable to further add (C) a quaternary ammonium salt. When (C) a quaternary ammonium salt is added, the effect of dispersing and removing the oral biofilm is further improved. Moreover, foaming is further improved.
Examples of the quaternary ammonium salt of component (C) include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, and the like. One or more of these may be used. More preferable from the viewpoint of film removal effect.
(C) When mix | blending a component, it is preferable from the point of the improvement of a biofilm removal effect that (A) / (C) mix | blends within the range of 10-500 as mass ratio.

In the present invention, particularly in the second invention, it is preferable to further blend (D) xylitol and / or erythritol. When (D) xylitol and / or erythritol is blended, the effect of dispersing and removing the oral biofilm is further improved. As the component (D), xylitol or erythritol may be blended alone, or xylitol and erythritol may be blended.
When (D) component is mix | blended, it is preferable from the point of the improvement of a biofilm removal effect that (A) / (D) mix | blends within the range of 0.01-5 as mass ratio.

  The oral biofilm remover of the first invention is suitably blended in the oral composition. In this case, in the composition for oral cavity of the invention I, the blending amount of the component (A) is preferably 0.3 to 5% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.5 to 5.0%. The biofilm removal effect improves as the blending amount increases, and if it is 0.3% or more, a sufficient biofilm removal effect can be imparted. Moreover, favorable foamability can be provided. When it is 5% or less, the bitterness does not become strong, which is preferable in use.

  Moreover, in the composition for oral cavity of the invention I, the blending amount of the component (B-1) is preferably 0.1 to 5%, more preferably 0.3 to 5%, still more preferably 0 of the whole composition. 30 to 5%. The blending amount of the component (B-1) increases as the biofilm removal effect is improved, but it is preferably 5% or less in order to suppress the bitterness, give good foaming, and obtain a preferable one for use.

  The oral biofilm remover of Invention II is suitably blended in the oral composition and contains (A) an alkyl sulfoacetate salt and (A) an amphoteric surfactant (B-2) as a component. Further, (C) a quaternary ammonium salt may be contained, and (D) xylitol and / or erythritol may be further contained. In particular, the dentifrice composition containing (A) component, (B-2) component, more preferably (C) component, or (A) component, (B-2) component, more preferably (D) component. When the mouthwash composition is contained, the oral biofilm removal effect is further improved.

  In the composition for oral cavity of the II invention, the blending amount of the component (A) is preferably 0.1 to 3% of the whole composition. In this case, particularly in the dentifrice composition, it is preferable to blend the component (A) in an amount of 0.3 to 3%, particularly 0.5 to 2.5%. Moreover, in a mouthwash composition, it is preferable to mix | blend (A) component 0.1 to 3%, especially 0.1 to 2.5%, especially 0.1 to 1%. The biofilm removal effect improves as the blending amount increases, and if it is 0.1% or more, a sufficient biofilm removal effect can be imparted. Moreover, favorable foamability can be provided. When it is 3% or less, the bitterness does not become strong, which is preferable in use.

  Moreover, in the composition for oral cavity of the II invention, the blending amount of the component (B-2) is preferably 0.05 to 5%, particularly preferably 0.1 to 5%, more preferably 0.3% of the whole composition. -5%, more preferably 0.5-3%. The blending amount of the component (B-2) increases as the biofilm removal effect is improved and gives good foaming, but is preferably 5% or less so as not to cause bitterness.

  (C) When a quaternary ammonium salt is blended, particularly in a dentifrice composition according to the invention II, the blending amount is preferably 0.003 to 0.05% of the total composition, more preferably 0.005. -0.01%. The biofilm removal effect increases as the blending amount increases. 0.05% or less is preferable so as not to cause mucosal irritation of the quaternary ammonium salt.

  (D) When xylitol and / or erythritol is blended, particularly in the mouthwash composition according to the invention II, the blending amount is preferably 0.1 to 2% of the total composition, more preferably 0.3 to 1%. The biofilm removal effect is further enhanced as the amount is increased. In order not to cause bitterness, 2% or less is preferable.

  The oral composition of the present invention can be prepared in the form of liquid, liquid, paste, etc., and is prepared by a usual method as a toothpaste, a toothpaste such as a toothpaste, a liquid toothpaste, a liquid toothpaste, a toothpaste, or a mouthwash. can do.

  In this case, in addition to the above components, if necessary, other optional components according to the dosage form can be blended within a range that does not impair the effects of the present invention. Specifically, in the case of dentifrice, abrasives, binders, thickeners, surfactants, sweeteners, preservatives, fragrances, pigments, various active ingredients, solvents such as water, pH adjusters, etc. Can be blended. In the case of a mouthwash, wetting agents, surfactants, solvents, pH adjusters, preservatives, bactericides, fragrances, sweeteners, pigments, various active ingredients, and the like can be blended.

Although the specific example of an arbitrary component is shown below, the component which can be mix | blended with the composition of this invention is not restrict | limited to these.
As the abrasive, silica-based abrasive such as crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, Examples thereof include aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, and synthetic resin-based abrasive. In the case of dentifrice, these abrasives can usually be blended in an amount of 5 to 70%, particularly 10 to 50% of the whole composition.

  Examples of the binder include pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinylpyrrolidone. Etc., and can be used singly or in combination of two or more. These binders can usually be blended in an amount of 0 to 10%, particularly 0.1 to 5% of the whole composition.

  Examples of the thickening agent (wetting agent) include polyhydric alcohols such as sorbit, propylene glycol, butylene glycol, glycerin, and polyethylene glycol. The blending amount of these thickeners is usually 0 to 70%, particularly 3 to 50% of the whole composition.

  As the surfactant, an anionic surfactant other than the component (A) and a nonionic surfactant can be blended, and examples thereof include anionic surfactants such as alkyl sulfates and sulfates of glycerin fatty acid esters, Use nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene glycerin fatty acid ester, sucrose fatty acid ester, fatty acid alkylolamide it can. These surfactants can be used alone or in combination of two or more, and can usually be blended in an amount of 0 to 10%, particularly 0.1 to 5% of the total composition. Further, the amount of the anionic surfactant other than the component (A) may be 0%, and when it is blended, it is preferably 0.1 to 1.5%, particularly preferably 0.1 to 1.0%.

  Examples of the sweetener include saccharin sodium, stevioside, neohesperidyl dihydrochalcone and the like. As preservatives, paraoxybenzoic acid esters such as sodium benzoate, methylparaben, and ethylparaben can be blended.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and l-mentor , Carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentane -3-Carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone , Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethanol For oral compositions such as single flavors such as luthioacetate, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The known perfume materials used can be used in combination.

  As the dye, a dye that can be used in the composition for oral cavity can be used depending on the target color tone. Examples of food dyes include brilliant blue and tartrazine, and examples of pigments include titanium oxide.

  Examples of active ingredients (medicinal ingredients) include bactericidal or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, zinc gluconate and zinc citrate, anticalculus agents such as ethanehydroxydiphosphonate, tranexamic acid, glycyrrhizic acid And salts thereof, anti-inflammatory agents such as allantochlorohydroxyaluminum, fluorides such as sodium fluoride and sodium monofluorophosphate, coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride, enzymes such as dextranase, mutanase and lysozyme chloride , Vitamins such as ascorbic acid and tocopherol acetate, astringents such as sodium chloride, hypersensitivity inhibitors such as aluminum lactate, strontium chloride and potassium nitrate, sodium fluoride, monoflux Sodium pyrophosphate, and fluoride such as stannous fluoride can be used effective amount within the range pharmaceutically acceptable.

Moreover, ethanol, water, etc. can be mix | blended as a solvent.
When the oral composition is a dentifrice composition, the solvent is preferably water, and the water content is preferably 60% or less of the total composition. When the oral composition is a mouthwash composition, the solvent is preferably water or a mixed solvent of water and ethanol, and ethanol is preferably 10% or less of the entire composition.
The pH of the composition can be in the range of a normal oral composition, but the pH at 25 ° C. is preferably 5.5 to 8.5, more preferably 6 to 8. If necessary, the pH may be adjusted using a pH adjuster, and examples of the pH adjuster include sodium hydroxide, hydrochloric acid, sodium carbonate, sodium hydrogen carbonate, boric acid or a salt thereof, Sodium oxide, potassium hydroxide and hydrochloric acid are preferred. The blending amount of these pH adjusters only needs to adjust the pH value within the above range.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Example I, Comparative Example I]
Dentifrice compositions having the compositions shown in Tables 1 and 2 were prepared by the following method and evaluated by the following method. The results are shown in Tables 1 and 2.

A method of preparing a dentifrice composition;
First, in purified water containing a viscous agent such as sorbite liquid, after mixing the condensed phosphate of component (B-1) and the required water-soluble component at room temperature, further mixing a binder and a stabilizer, Dispersed with a disper. A dispersion and an abrasive were placed in a kneader and mixed, and then a fragrance and an alkylsulfoacetate salt as component (A) were added. The inside of the kneader was degassed by reducing the pressure to about 5 kPa, and further mixing was continued to obtain a dentifrice composition. In addition, the composition of the comparative example was prepared according to the said method.

<Evaluation method of oral biofilm removal effect>
(1) Production method of model biofilm What was treated for 4 hours with human unstimulated saliva obtained by filtering a hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm with a 0.45 μm filter. A basal medium mucin culture solution (BMM) ^{* 1} was used as a model biofilm carrier and a culture solution. The strains used to make the model biofilms were Actinomyces viscosus ATCC 43146, Baylonella parvula ATCC1745, ATCC1745, ATCC1745, ATCC1745. oralis) ATCC 10557, Streptococcus mutans ATCC 25175. These 5 strains were inoculated to 1 × 10 ⁷ cfu / mL (cfu: colony forming units) in a Rotating Disk Reactor (culture tank) containing 3,000 mL of BMM in advance, and 37 ° C. with a saliva-treated HA carrier. The cells were cultured for 24 hours under anaerobic conditions (5 vol% carbon dioxide gas, 95 vol% nitrogen). Thereafter, a BMM medium was continuously supplied under the same conditions at a substitution rate of 5 vol% / hour and cultured for 10 days to form a model biofilm of 5 species mixed on the HA surface.

(2) Model biofilm removal effect The formed model biofilm was transferred to a 24-well multiplate (manufactured by Sumitomo Bakelite Co., Ltd.), and the prepared dentifrice composition (centrifugation of a 3-fold diluted solution with saliva collected from a healthy person) 2 mL of the supernatant (10,000 rpm, 10 minutes)) was added and immersed for 3 minutes (the sample without the dentifrice composition was used as a control sample). Thereafter, the plate was washed 6 times with 1 mL of PBS (manufactured by Wako Pure Chemical Industries, Ltd.) and dispersed by sonication (200 μA, 10 seconds) in a test tube (diameter 13 mm × 100 mm) to which 2 mL of PBS was added. The turbidity (OD) at a wavelength of 550 nm of this dispersion was measured to measure the residual amount of biofilm.
The biofilm removal effect of the test composition was determined by calculating the removal rate relative to the control by the following formula, and determining the oral biofilm removal effect from this removal rate according to the following criteria.
Biofilm removal rate (%) = (turbidity of control−turbidity of treatment of test composition) / turbidity of control × 100
Judgment criteria for oral biofilm removal effect ◎: Biofilm removal rate is 95% or more ◎: Biofilm removal rate is 90% or more and less than 95% ○: Biofilm removal rate is 80% or more and less than 90% △: Biofilm removal Rate is 70% or more and less than 80% ×: Biofilm removal rate is 50% or more and less than 70% XX: Biofilm removal rate is less than 50%

^{* 1} BMM composition: Expressed by mass in 1 liter.
Proteose peptone (Becton and Dickinson): 4g / L
Tryptone (Becton and Dickinson): 2g / L
Yeast extract (Becton and Dickinson): 2g / L
Mucin (manufactured by Sigma): 5 g / L
Hemin (manufactured by Sigma): 2.5 mg / L
Vitamin K (manufactured by Wako Pure Chemical Industries): 0.5mg / L
KCl (Wako Pure Chemical Industries, Ltd.): 1g / L
Cysteine (Wako Pure Chemical Industries, Ltd.): 0.2 g / L
Distilled water: remaining (The volume was increased to 1 L, and autoclaved at 121 ° C. for 20 minutes.)

<Evaluation method for bitterness and foaming>
The dentifrice composition of the dentifrice composition shown in the table and the good foaming were sensory-evaluated by the following methods.
1 g of the dentifrice composition was taken on a toothbrush and brushed for 3 minutes, and evaluated according to the following criteria. The lack of bitterness and good foaming were evaluated based on the following evaluation criteria from the average of 6 evaluators.

No bitterness Criteria 5: Feels no bitterness 4: Feels little bitterness 3: Feels slightly bitter 2: Feels bitterness 1: Feels strong bitterness Evaluation standard ◎: Average value is 4 or more and 5 or less ○: Average value is 3 or more and less than 4 points △: Average value is 2 or more and less than 3 points ×: Average value is 1 or more and less than 2 points

Good foaming rating criteria 5: Very good foaming 4: Good foaming 3: Normal foaming 2: Slightly bad foaming 1: Very poor foaming Evaluation criteria ◎: Average value is 4 or more and 5 or less ○ : Average value of 3 points or more and less than 4 points Δ: Average value of 2 points or more and less than 3 points ×: Average value of 1 point or more and less than 2 points

Details of the raw materials used are shown below.
(A) Component Sodium lauryl sulfoacetate; Nikko Chemicals Co., Ltd. (B) Component (B-1) Sodium tripolyphosphate; Taihei Chemical Industrial Co., Ltd. (B-1) Sodium pyrophosphate; Taihei Chemical Industrial Co., Ltd. (B-1) Potassium pyrophosphate; manufactured by Taihei Chemical Industry Co., Ltd.

[Example II, Comparative Example II]
The compositions for oral cavity having the compositions shown in Tables 3 to 6 (Tables 3 and 4 are dentifrice compositions, Tables 5 and 6 are mouthwash compositions) are prepared by the methods shown below and evaluated in the same manner as described above. did. The results are shown in Tables 3-6.
In addition, sensory evaluation was performed by the following method about the bitterness of a mouthwash composition and the good foaming.
After rinsing for 20 seconds with 10 mL of mouthwash, the absence of bitterness at the time of mouthwash was determined based on the above criteria. Evaluation was performed based on the above evaluation criteria from the average of 6 evaluators.

A method of preparing a dentifrice composition;
First, after mixing the desired water-soluble components such as sodium fluoride in purified water containing a thickener such as sorbite liquid at room temperature, the (B-2) component is further mixed with the binder and dispersed with a disper. It was. After mixing and mixing powder, such as a dispersion liquid and an abrasive | polishing agent, in a kneader, the fragrance | flavor and (A) component were added. The inside of the kneader was degassed by reducing the pressure to about 5 kPa, and further mixing was continued to obtain a dentifrice composition.
A method of preparing a mouthwash composition;
The preparation of the mouthwash composition was carried out by sequentially adding the component (A), the component (B-2) and other raw materials to purified water and stirring to dissolve them uniformly. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.
The dentifrice composition and mouthwash composition of Comparative Examples were prepared according to the above method.

Details of the raw materials used are shown below.
(A) Component Sodium lauryl sulfoacetate; (B) component manufactured by Nikko Chemicals Co., Ltd. (B-2) Coconut oil fatty acid amidopropyl betaine; 30% product (arrangement in each example)
Total amount is pure fraction), TEGO Betaine CK OK, EV
Made by ONIK

  As is clear from the results of the table, when the component (A) and the component (B) are used in combination, the effect of removing the oral biofilm is significantly improved. Moreover, bitterness was suppressed. Furthermore, oral compositions, particularly dentifrice compositions, had moderate foaming.

  Hereinafter, a prescription example is shown. The raw materials used are the same as described above. The following mouth washes were excellent in oral biofilm removal effect, bitterness was suppressed, and foaming was good.

[Prescription Example I-1] Mouthwash (A) Sodium lauryl sulfoacetate 0.8%
(B) (B-1) Sodium tripolyphosphate 0.5
Polyoxyethylene (60) hydrogenated castor oil 0.3
Glycerin 5
Propylene glycol 4
Xylitol 2
Sodium benzoate 0.2
Citric acid 0.02
Sodium citrate 0.2
Fragrance 0.2
Water remaining
Total 100.0%
(A) / (B-1) ratio; 1.6

Claims (8)

  It consists of (A) alkylsulfoacetate and (B) condensed phosphate (B-1) and / or amphoteric surfactant (B-2), where (A) / (B-1) is the mass ratio. An oral biofilm remover in which 0.1 to 10 or (A) / (B-2) is 0.2 to 8 as a mass ratio.   (B-2) The oral biofilm remover according to claim 1, wherein the amphoteric surfactant is one or more betaine amphoteric surfactants selected from fatty acid amide alkylbetaines, imidazolinium betaines and aminoacetic acid betaines.   The oral biofilm remover according to claim 1 or 2, wherein the alkyl sulfoacetate as component (A) is lauryl sulfoacetate. The oral biofilm remover according to any one of claims 1 to 3 , further comprising (D) xylitol and / or erythritol. (A) 0.3-5 mass% of alkyl sulfoacetates and (B) 0.1-5 mass% of sodium tripolyphosphate (B- 1 ′) , (A) / (B- 1 oral composition characterized by ') is from 0.1 to 10 as a mass ratio. Furthermore, (D) The composition for oral cavity of Claim 5 which contains 0.1-2 mass% of xylitol and / or erythritol. The composition for oral cavity according to any one of claims 5 and 6 , which is a dentifrice composition or a mouthwash composition. The composition for oral cavity according to any one of claims 5 to 7 , which is used for removing an oral biofilm.