KR102146681B1 - Elimination agent for oral cavity biofilm and oral cavity composition - Google Patents

Abstract

(A) an oral biofilm remover consisting of α-olefin sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2), and the (A) component and (B) component It provides a composition for oral cavity containing high oral biofilm removal effect.

Description

Oral biofilm remover and oral composition {ELIMINATION AGENT FOR ORAL CAVITY BIOFILM AND ORAL CAVITY COMPOSITION}

The present invention relates to an oral biofilm remover and a composition for oral cavity having a high effect of chemically removing a biofilm that causes caries.

Conventionally, plaque (tartar) removal techniques in toothpaste include physical removal by cleaning agents such as abrasives, biochemical removal by enzymes, and the like.

In the removal with a cleaning agent, it is necessary to increase the amount of the abrasive or increase the hardness in order to exhibit the effect, but there is a possibility that the polishing power is improved, and the risk such as tooth or gum damage, and irritation are likely to occur. On the other hand, in order to stably mix the enzyme, it is necessary to use various stabilizers in combination, and there are cases where it affects the feeling of use such as foaming and taste.

In addition, recently, if the biofilm can be removed by capturing the calculus as a biofilm, it is possible to remove the calculus more effectively. In order to remove the biofilm in the oral cavity, not only a physical method by brushing using a toothbrush, but also a chemical method capable of removing the biofilm that does not close the brush is useful. Biofilm is composed of coaggregates of various oral bacteria and extracellular polysaccharides. Therefore, as a chemical removal method, it is known to use erythritol, which has a coagulation inhibitory effect, or protease, dextranase, mutanase, etc., which are enzymes that degrade extracellular polysaccharides, but the effect has room for improvement.

In addition, surfactants are known to have a cleaning action, and are used in oral compositions as cleaning agents. In this case, sodium laurylsulfoacetate is known as a non-irritating activator peculiar to anionic surfactants (Patent Document 1: Japanese Patent Laid-Open No. 6-72836).

However, conventionally, surfactants have been recognized as having a slight but calculus removal effect from the viewpoint of their penetration and surface cleaning action, but it is not recognized that the use of surfactant alone has sufficient effect of removing calculus or biofilm. This is the current situation.

In addition, Patent Document 2 (Japanese Patent Publication No. 2008-519043) discloses the combination of an alkali metal salt or ammonium salt of alkyl sulfoacetate and a water-soluble zinc salt, but alkyl sulfoacetate is used to reduce the astringency of zinc salts. As a result, the biofilm removal effect is not shown. In addition, Patent Document 3 (Japanese Patent Laid-Open No. 9-508120) discloses a tube toothpaste containing sodium lauryl sulfoacetate as an oral composition with reduced irritation to the oral mucosa, but mentions the biofilm removal effect. Not done.

On the other hand, it is known that condensed phosphate has a chemical decontamination effect on teeth (Patent Document 4: Japanese Patent Laid-Open No. 9-175966), but it is not recognized that condensed phosphate alone has sufficient effect of removing calculus or biofilm. not.

Japanese Patent Laid-Open Publication No. Hei 6-72836 Japanese Patent Publication No. 2008-519043 Japanese Patent Laid-Open Publication No. Hei 9-508120 Japanese Patent Laid-Open No. Hei 9-175966

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral biofilm remover and a composition for oral cavity having a high effect of chemically removing a biofilm that causes caries.

In order to achieve the object of the present invention, the present invention has conducted a thorough study, and as a result, (A) α-olefin sulfonate, and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2) By using it together, it found out what can solve the said subject.

In detail, the present inventors believe that (A) α-olefin sulfonate and (B) condensed phosphate (B-1) are combined to significantly improve the removal effect of the oral biofilm, and (A) What can suppress taste and what can give moderate foaming was found (Invention I).

In the first invention, components (A) and (B-1) are particularly specific in the range of 0.1-10 as the mass ratio of (A)/(B-1) and act synergistically to disperse oral biofilm. The action to remove is enhanced. Further, it is possible to suppress the bitter taste derived from the component (A), and to provide adequate foaming due to the component (A).

That is, as shown in Examples and Comparative Examples to be described later, when the α-olefin sulfonate salt of component (A) is used alone, the removal rate of the produced biofilm is less than 70%. In addition, the biofilm removal rate in the condensed phosphate (B-1) is less than 50%, and although there is no sufficient biofilm removal effect, when the component (A) and the component (B-1) are used together, unexpectedly It was found that both components act synergistically to obtain a sufficient biofilm removal effect. In this case, even if anionic surfactants other than the component (A), for example, sodium lauryl sulfate and condensed phosphate are used in combination, a sufficient biofilm removal effect is not obtained, and the biofilm removal effect is the (A) component and ( It found that it was a specific action effect when a component B-1) was used together. In addition, α-olefin sulfonate has a bitter taste, and its use has been disclosed in the literature in the past, but was actually avoided in oral preparations, but the (A) component and (B-1) component are used in combination. The lower surface (A) found that the bitter taste derived from the component was suppressed to give a good feeling of use, and that the proper foaming caused by the (A) component was maintained, and the formulation was actually suitable for use, and the present invention was achieved.

In addition, the present inventors conducted a thorough study to achieve the subject of the present invention. As a result, by combining (A) α-olefin sulfonate and (B) amphoteric surfactant (B-2), the effect of removing oral biofilm (A) found that the bitter taste peculiar to the component (A) can be suppressed, and that appropriate foaming can be provided (II invention).

In the second invention, components (A) and (B-2) are particularly specific and synergistically acting within the range of 0.2 to 8 as the mass ratio of (A)/(B-2) to disperse oral biofilm. The action to remove is enhanced. Further, it is possible to suppress the bitter taste derived from the component (A), and to provide adequate foaming due to the component (A).

That is, as shown in Examples and Comparative Examples to be described later, when the α-olefin sulfonate salt of component (A) is used alone, the removal rate of the produced biofilm is less than 70%. In addition, the biofilm removal rate in the amphoteric surfactant (B-2) does not reach 50%, and there is no sufficient biofilm removal effect, and it cannot be considered that it improves the biofilm removal effect even if it is used in combination with other surfactants. In spite of this, it was found that when the component (A) and the component (B-2) were used in combination, unexpectedly, both components acted synergistically, and a sufficient biofilm removal effect was obtained by the surfactant system. In this case, even if anionic surfactant other than component (A), for example, sodium lauryl sulfate and amphoteric surfactant are used in combination, a sufficient biofilm removal effect is not obtained, and the biofilm removal effect is (B-2) It found that it was a specific action and effect when a component was used together. In addition, α-olefin sulfonate has a bitter taste, and its use has been disclosed in the literature in the past, but its use has been avoided in practice. However, if the component (A) and the component (B-2) are used together The present invention was achieved by discovering that the bitter taste derived from the component (A) was suppressed to impart a good feeling of use, and that the appropriate foaming caused by the component (A) was maintained, resulting in a formulation suitable for practical use.

In the second invention, when (C) a quaternary ammonium salt, (D) xylitol and/or erythritol are added, it is possible to impart a specifically superior oral biofilm removal effect.

In this case, in particular, a dentifrice composition containing (A) component, (B-2) component, more preferably (C) component, or (A) component, (B-2) component, more preferably ( It is more preferable that it is a mouthwash composition containing D) component.

Accordingly, the present invention (invention I) provides the following oral biofilm remover and oral composition.

[I-1] An oral biofilm remover comprising (A) an α-olefin sulfonate and (B-1) a condensed phosphate.

[I-2] The oral biofilm remover according to [I-1], wherein (A)/(B-1) is 0.1 to 10 as a mass ratio.

[I-3] The oral biofilm remover according to [I-1] or [I-2], wherein the α-olefin sulfonate salt of the component (A) is an α-olefin sulfonate salt having 14 to 16 carbon atoms.

[I-4] A composition for oral cavity comprising (A) α-olefin sulfonate and (B-1) condensed phosphate.

[I-5] The oral composition according to [I-4], wherein (A)/(B-1) is 0.1 to 10 as a mass ratio.

[I-6] The oral composition according to [I-4] or [I-5] containing 0.3 to 5% by mass of the α-olefin sulfonate as the component (A).

[I-7] The oral composition according to [1-4], [I-5], or [I-6] containing 0.1 to 5% by mass of the condensed phosphate of the component (B-1).

〔I-8〕

The oral composition according to any one of [I-4] to [I-7], which is a toothpaste composition or an oral rinse composition.

[I-9] The oral composition according to any one of [I-4] to [I-8] for removing oral biofilm.

Accordingly, the present invention (II invention) provides the following oral biofilm remover and oral composition.

[II-1] An oral biofilm remover comprising (A) an α-olefin sulfonate and (B-2) an amphoteric surfactant.

[II-2] The oral biofilm remover according to [II-1], wherein (A)/(B-2) is 0.2 to 8 as a mass ratio.

[II-3] [II-1] wherein the amphoteric surfactant of component (B-2) is at least one betaine-based amphoteric surfactant selected from fatty acid amide alkyl betaine, imidazolinium betaine and amino acetate betaine, or The oral biofilm remover according to [II-2].

[II-4] The oral biofilm remover according to [II-1], [II-2], or [II-3], wherein the α-olefin sulfonate salt of the component (A) is an α-olefin sulfonate salt having 14 to 16 carbon atoms. .

[II-5] (C) The oral biofilm remover according to any one of [II-1] to [II-4] further comprising a quaternary ammonium salt.

[II-6] The oral biofilm remover according to [II-5], wherein the quaternary ammonium salt of the component (C) is at least one selected from cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride.

[II-7] (D) The oral biofilm remover according to any one of [II-1] to [II-6], further containing xylitol and/or erythritol.

[II-8] An oral composition comprising (A) α-olefin sulfonate and (B-2) amphoteric surfactant.

[II-9] The oral composition according to [II-8], wherein (A)/(B-2) is 0.2 to 8 as a mass ratio.

[II-10] [II-8] or [II-9] containing 0.1 to 3 mass% of α-olefin sulfonate as component (A) and 0.05 to 5 mass% of amphoteric surfactant as component (B-2) The oral composition according to [].

[II-11] (C) The oral composition according to [II-8], [II-9], or [II-10], further containing 0.003 to 0.05% by mass of a quaternary ammonium salt.

[II-12] (D) The oral composition according to any one of [II-8] to [II-11], further containing 0.1 to 2% by mass of xylitol and/or erythritol.

[II-13]

The oral composition according to any one of [II-8] to [II-12], which is a toothpaste composition or an oral rinse composition.

[II-14] The oral composition according to any one of [II-8] to [II-13] for removing oral biofilm.

(Effects of the Invention)

The oral biofilm remover and the oral composition of the present invention are excellent in chemical removal effect of the oral biofilm that causes caries. In addition, the bitter taste is suppressed, giving a good feeling of use, and giving moderate foaming.

Hereinafter, the present invention will be described in more detail.

The present invention is an oral biofilm remover comprising (A) α-olefin sulfonate, and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2). Further, the present invention is a composition for oral cavity containing the components (A) and (B).

In the present invention, the first invention is characterized in that (A) α-olefin sulfonate and (B) condensed phosphate (B-1) are used in combination as a component.

By using (A) α-olefin sulfonate and component (B-1) in combination, the effect of dispersing and removing the biofilm can be significantly improved, and the bitter taste of the component (A) is suppressed, and the foaming property is appropriately imparted. You may.

(A) As the α-olefin sulfonic acid salt, alkali metal salts such as sodium and potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and the α-olefin sulfonate salt having 14 carbon atoms is preferable. These are possible to obtain commercial products that can be used in oral preparations.

The condensed phosphate (B-1) of the component (B) used in the first invention improves the biofilm removal effect when used in combination with the component (A), suppresses bitter taste, and imparts moderate foaming properties.

As the condensed phosphate of the component (B), the following general formula (1)

M _n+2 P _n O _3n+1 (1)

(In the formula, M represents Na or K, and n≥2.)

The linear water-soluble polyphosphate represented by can be used. For example, sodium pyrophosphate or potassium pyrophosphate with a degree of polymerization n = 2, sodium tripolyphosphate or potassium tripolyphosphate with n = 3, sodium tetrapolyphosphate or potassium tetrapolyphosphate with n = 4, sodium pentapolyphosphate with n = 5 And also sodium metaphosphate and potassium metaphosphate having a high degree of polymerization. These may be used singly or in combination of two or more, but among them, sodium pyrophosphate, potassium pyrophosphate, and sodium tripolyphosphate are more preferable from the viewpoint of the effect, and sodium tripolyphosphate is particularly preferable.

Specifically, sodium pyrophosphate (manufactured by Taihei Chemical Industry Co., Ltd., manufactured by Tohoku Chemical Industry Co., Ltd.), potassium pyrophosphate (manufactured by Taihei Chemical Industry Co., Ltd., and Toa Kosei Chemical Co., Ltd.), Sodium tripolyphosphate (manufactured by Taihei Chemical Industries, Ltd., Central Glass Corporation, Nippon Hilder Corporation), potassium tripolyphosphate (manufactured by Taihei Chemical Industries, Ltd.), sodium tetrapolyphosphate (Taihei Chemical Industry Co., Ltd. product), pentapolyphosphate sodium (Taihei Chemical Industry Co., Ltd. product), etc. can be used.

In the first invention, when the blending ratio of the component (A) and the component (B-1) is within a specific range, the oral biofilm removal effect is more excellent. The ratio of (A)/(B-1) is not particularly limited, but the mass ratio is preferably 0.1 to 10, more preferably 0.2 to 5, still more preferably 0.6 to 3, and particularly preferably 1.2 to 3 .

If it is within the above ratio range, the biofilm removal effect is more excellent. Further, in order to suppress bitter taste and impart good foaming, the ratio value is preferably 10 or less.

Further, in the present invention, the second invention is characterized in that (A) α-olefin sulfonate and (B) an amphoteric surfactant (B-2) are used in combination as a component.

By using (A) α-olefin sulfonate and component (B-2) in combination, the effect of dispersing and removing the biofilm can be significantly improved, and bitter taste of the component (A) is suppressed, and foaming property is appropriately imparted. You may.

In this case, the component (A) is the same as the first invention.

The amphoteric surfactant (B-2) of the component (B) used in the second invention is used in combination with the component (A) to remarkably improve the dispersion and removal effect of the oral biofilm, suppress bitter taste, and moderate foaming. Is given.

As the amphoteric surfactant, betaine-based, for example, fatty acid amide alkyl betaine, imidazolinium betaine, aminoacetic acid betaine, can be used. Among them, a fatty acid amide alkyl betaine having 8 to 18 carbon atoms and an alkyl group having 1 to 5 carbon atoms is preferred, and a fatty acid amide propyl betaine is more preferred. As such fatty acid amide propyl betaine, a palm oil fatty acid amide propyl betaine described in Won-gyu Oe (Quasi-drug raw material standard) can be used.

As for the amphoteric surfactant, a commercial product that can be used in an oral formulation can be obtained. Specifically, as palm oil fatty acid amide propylbetaine, a commercially available brand name TEGO Betain CK OK (manufactured by EVONIK) is exemplified.

In the second invention, when the blending ratio of the component (A) and the component (B-2) is within a specific range, the oral biofilm removal effect is more excellent. In this case, the (A)/(B-2) ratio is preferably 0.2 to 8 as a mass ratio, more preferably 0.4 to 5, still more preferably 0.4 to 4, and particularly preferably 0.5 to 3.1. If it is within the above ratio range, the biofilm removal effect is more excellent. Further, in order to provide better foaming and further suppress bitterness, it is preferably 8 or less.

In the present invention, particularly in the second invention, it is preferable to further mix (C) a quaternary ammonium salt, and when (C) a quaternary ammonium salt is added, the dispersion and removal effect of the oral biofilm is further improved. Also, foaming is further improved.

(C) As the quaternary ammonium salt of the component, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, etc. can be mentioned, and one or two or more of these can be used, but in particular, cetylpyridinium chloride removes the biofilm. It is more preferable in terms of effect.

In the case of blending the component (C), it is preferable to blend (A)/(C) in the range of 10 to 500 as a mass ratio from the viewpoint of improving the biofilm removal effect.

In the present invention, particularly in the second invention, it is also preferable to blend (D) xylitol and/or erythritol, and when blending (D) xylitol and/or erythritol, the dispersion and removal effect of the oral biofilm is further improved. Further, as the component (D), xylitol or erythritol may be blended alone, or xylitol and erythritol may be blended.

In the case of blending the component (D), it is preferable to blend (A)/(D) in the range of 0.01 to 5 as a mass ratio from the viewpoint of improving the biofilm removal effect.

The oral biofilm remover of the first invention is preferably blended into the oral composition. In this case, in the oral composition of the first invention, the compounding amount of the component (A) is preferably 0.3 to 5% (mass%, hereinafter the same) of the entire composition, more preferably 0.5 to 5.0%. The larger the blending amount, the better the biofilm removal effect, and if it is 0.3% or more, a sufficient biofilm removal effect can be provided. Further, it is possible to impart good foaming properties. If it is less than 5%, the bitter taste does not become strong, so it is preferable for use.

In addition, in the composition for oral cavity of the first invention, the amount of the component (B-1) is preferably 0.1 to 5%, more preferably 0.2 to 5%, and still more preferably 0.3 to 5% of the total composition. The biofilm removal effect improves as the blending amount of the component (B-1) increases, but it is preferably 5% or less in order to suppress bitter taste and impart good foam generation to obtain a desirable product for use.

The oral biofilm remover of the II invention is preferably blended into the oral composition, and contains (A) α-olefin sulfonate and (B) an amphoteric surfactant (B-2) as a component, and more preferably (C ) A quaternary ammonium salt is contained, and more preferably (D) xylitol and/or erythritol is contained. Particularly, a toothpaste composition containing a component (A), a component (B-2), more preferably a component (C), or a component (A), a component (B-2), more preferably a component (D) If it is a mouthwash composition containing the oral biofilm removal effect is further improved.

In the composition for oral cavity of the second invention, the amount of the component (A) is preferably 0.1 to 3% of the total composition. In this case, in particular, in the toothpaste composition, it is preferable to blend the component (A) by 0.3 to 3%, particularly 0.5 to 2.5%. In addition, in the oral rinse composition, it is preferable to blend (A) component 0.1 to 3%, particularly 0.1 to 2.5%, and particularly 0.1 to 1%. The greater the blending amount, the better the biofilm removal effect, and if it is 0.1% or more, a sufficient biofilm removal effect can be provided. Further, it is possible to impart good foaming properties. If it is less than 3%, the bitter taste does not become strong, so it is preferable for use.

In addition, in the composition for oral cavity of the second invention, the blending amount of the component (B-2) is preferably 0.05 to 5%, particularly preferably 0.1 to 5%, more preferably 0.3 to 5%, further preferably 0.5 to 3%. (B-2) The greater the blending amount of the component, the better the biofilm removal effect is, and the better foaming is imparted, but in order not to produce bitter taste, 5% or less is preferable.

(C) In the case of blending a quaternary ammonium salt, particularly in the toothpaste composition according to the second invention, the blending amount is preferably 0.003 to 0.05% of the total composition, and more preferably 0.005 to 0.01%. The higher the blending amount, the higher the biofilm removal effect. In order not to cause mucosal irritation of the quaternary ammonium salt, it is preferably 0.05% or less.

(D) In the case of blending xylitol and/or erythritol, particularly in the mouthwash composition according to the second invention, the blending amount is preferably 0.1 to 2% of the total composition, and more preferably 0.3 to 1%. The higher the blending amount, the higher the biofilm removal effect. In order not to generate bitter taste, it is preferably 2% or less.

The oral composition of the present invention can be prepared in the form of liquid, liquid, paste, etc., and can be prepared by conventional methods as toothpaste such as tube toothpaste, liquid toothpaste, liquid toothpaste, and luster toothpaste, and mouthwash. .

In this case, in addition to the above ingredients, other optional ingredients according to the formulation may be blended as needed within a range not impairing the effects of the present invention. Specifically, in the case of toothpaste, an abrasive, a caking agent, a viscous agent, a surfactant, a sweetener, a preservative, a flavoring agent, a colorant, various active ingredients, a solvent such as water, a pH adjusting agent, and the like can be blended. In the case of mouthwash, wetting agents, surfactants, solvents, pH adjusters, preservatives, disinfectants, flavors, sweeteners, pigments, various active ingredients, and the like can be blended.

Specific examples of the optional components are shown below, but the components that can be blended in the composition of the present invention are not limited thereto.

As abrasives, silica-based abrasives such as crystalline silica, amorphous silica, silica gel, and aluminosilicates, zeolites, calcium hydrogen phosphate anhydride, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, Tertiary magnesium phosphate, zirconium silicate, tertiary calcium phosphate, hydroxyapatite, quaternary calcium phosphate, synthetic resin-based abrasives, and the like. These abrasives, in the case of conventional toothpaste, can be blended in 5 to 70%, particularly 10 to 50% of the total composition.

As a binder, for example, pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locast Bean gum, polyvinyl alcohol, polyvinylpyrrolidone, and the like, and may be used singly or in combination of two or more. These binders can usually be blended in an amount of 0 to 10%, particularly 0.1 to 5% of the total composition.

As a viscous agent (wetting agent), polyhydric alcohols, such as sorbit, propylene glycol, butylene glycol, glycerin, and polyethylene glycol, are mentioned, for example. The blending amount of these viscous agents is usually 0 to 70%, particularly 3 to 50% of the total composition.

As surfactants, anionic surfactants and nonionic surfactants other than component (A) can be blended, for example, anionic surfactants such as alkyl sulfates and sulfates of glycerin fatty acid esters, polyoxyethylene alkyl ethers, and polyoxy Nonionic surfactants such as ethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene glycerin fatty acid ester, sucrose fatty acid ester, and fatty acid alkyrolamide can be used. One or two or more of these surfactants can be used, and usually 0 to 10%, particularly 0.1 to 5% of the total composition can be blended. Further, the blending amount of the anionic surfactant other than the component (A) may be 0%, and when blending, 0.1 to 1.5%, particularly preferably 0.1 to 1.0%.

Examples of the sweetener include sodium saccharine, stevioside, and neohesperidyl dihydrochalcone. As a preservative, para-oxybenzoic acid esters, such as sodium benzoate, methylparaben, and ethylparaben, etc. can be blended.

Peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender Oil, rosemary oil, laurel milk, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, ducknam oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil, yuzu oil , Iris Concrete, Absolut Peppermint, Absolut Rose, Orange Flower, and other natural fragrances, and fragrances obtained by processing these natural fragrances (current part cut, tail part cut, sorting, liquid extraction, essence, powder flavoring, etc.), and , l-menthol, carbonyl, anethol, cineol, methyl salicylate, cinnamicaldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalol, linalyl acetate, limonene, Menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral, fulegon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate , Methylanthranylate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate, etc. It is used in oral compositions such as single-piece fragrances, and combination fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, hertz mix flavor, tropical fruit flavor, etc. Known flavoring materials can be used in combination.

As the pigment, a pigment usable in the oral composition can be used depending on the desired color tone. Examples of food coloring include brilliant blue and tatrazine, and examples of pigment include titanium oxide.

As active ingredients (medicinal ingredients), for example, bactericidal or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, zinc gluconate, and zinc citrate, anti-tartar agents such as ethanehydroxydiphosphonate, tranexamic acid, and glycine. Silicic acid and its salts, anti-inflammatory agents such as arantine chlorohydroxyaluminum, fluorides such as sodium fluoride and sodium monofluorophosphate, coating agents such as hydroxyethylcellulose dimethyl diallylammonium chloride, dextranase, mutanase , Enzymes such as lysozyme chloride, vitamins such as ascorbic acid and tocopherol acetate, astringents such as sodium chloride, hypersensitivity inhibitors such as aluminum lactate, strontium chloride, and potassium nitrate, sodium fluoride, sodium monofluorophosphate, stannous fluoride, etc. It can be used in an effective amount within a pharmaceutically acceptable range.

Moreover, ethanol, water, etc. can be blended as a solvent.

When the oral composition is a toothpaste composition, the solvent is preferably water, and the content of water is preferably 60% or less of the total composition. In addition, when the oral composition is a mouthwash composition, the solvent is preferably water or a mixed solvent of water and ethanol, and ethanol is preferably 10% or less of the total composition.

The pH of the composition can be in the range of an ordinary oral composition, but preferably the pH at 25°C is 5.5 to 8.5, more preferably 6 to 8. In addition, if necessary, the pH may be adjusted using a pH adjusting agent, and examples of the pH adjusting agent include sodium hydroxide, hydrochloric acid, sodium carbonate, sodium hydrogen carbonate, boric acid, or a salt thereof, and among them sodium hydroxide, potassium hydroxide, and hydrochloric acid are preferable. Do. The blending amount of these pH adjusting agents should just be able to adjust the pH value within the above range.

Example

Hereinafter, examples, comparative examples, and prescription examples are shown, and the present invention is specifically described, but the present invention is not limited to the following examples. In addition, in the following examples, all represent% by mass unless otherwise specified.

[Example I, Comparative Example I]

The toothpaste composition of the composition shown in Tables 1 and 2 was prepared by the method shown below, and evaluated by the following method. The results are recorded in Tables 1 and 2.

A method of preparing a toothpaste composition;

First, the condensed phosphate of the component (B-1) and the water-soluble component for use were mixed at room temperature in purified water containing a viscous agent such as sorbit liquid, and then a caking agent and a stabilizer were mixed and dispersed with a disper. The dispersion liquid and the abrasive were put in a kneader, and after mixing, a fragrance and an α-olefin sulfonate as component (A) were added. The inside of the kneader was depressurized to about 5 kPa, defoaming, and further mixing was continued to obtain a toothpaste composition. Moreover, the composition of a comparative example was prepared according to the said method.

<Evaluation method of oral biofilm removal effect>

(1) Manufacturing method of model biofilm

A 7 mm diameter x 3.5 mm thick hydroxyapatite (HA) plate (manufactured by Asahi Kogaku Corporation) was treated with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours and used as a carrier for making a model biofilm. Baysalmidium mucin culture solution (BMM) ^*1 was used. The strains used to produce the model biofilm are Actinomyces viscosus ATCC43146, Veillonella parvula ATCDC17745, Fusobacterium nucleatum purchased from American Type Culture Collection. ATCC10953, Streptococcus oralis ATCC10557, Streptococcus mutans ATCC25175 were used. These 5 strains were inoculated to each 1×10 ⁷ cfu/mL (cfu: colony forming units) in a Rotating Disk Reactor (culture tank) containing 3,000 mL of BMM in advance, and 37°C, anaerobic with a saliva-treated HA carrier. It was incubated for 24 hours under conditions (5 vol% carbon dioxide gas, 95 vol% nitrogen). Thereafter, under the same conditions, the BMM medium was continuously supplied at a rate of substitution rate of 5 vol%/hour and cultured for 10 days to form a model biofilm of 5 species mixture on the HA surface.

(2) Removal effect of model biofilm

The formed model biofilm was transferred to a 24-hole multi-plate (manufactured by Sumitomo Bakelite), and 2 mL of the prepared toothpaste composition (centrifugal supernatant (10,000 rpm, 10 minutes) in a 3-fold dilution with saliva collected from a dry merchant) was added. , It was immersed for 3 minutes (the thing which did not add a toothpaste composition was made into a control sample). Thereafter, it was washed 6 times with 1 mL of PBS (manufactured by Wako Pure Chemical Industries, Ltd.), and dispersed by ultrasonic treatment (200 μA, for 10 seconds) in a test tube (diameter 13 mm x 100 mm) to which 2 mL of the same PBS was added. The turbidity (OD) at a wavelength of 550 nm of this dispersion was measured to measure the amount of biofilm remaining.

As for the biofilm removal effect of the test composition, the removal rate for the control was determined by the following equation, and the oral biofilm removal effect was determined based on the following criteria from this removal rate.

Biofilm removal rate (%) = (turbidity of the control-turbidity of the test composition treatment) / turbidity of the control × 100

Criteria for determining the effect of removing oral biofilm

◎◎: Biofilm removal rate over 95%

◎: Biofilm removal rate is more than 90% and less than 95%

○: Biofilm removal rate is more than 80% and less than 90%

△: Biofilm removal rate is more than 70% and less than 80%

×: Biofilm removal rate is 50% or more and less than 70%

××: Biofilm removal rate is less than 50%

^*1 The composition of BMM is expressed as the mass in 1 liter.

Proteospeptone

(Becton and Dickinson company make): 4 g/L

Trypton

(Becton and Dickinson company make): 2g/L

Yeast extract

(Becton and Dickinson company make): 2g/L

Mucin (manufactured by Sigma): 5g/L

Hemin (manufactured by Sigma): 2.5mg/L

Vitamin K (made by Wako Junyaku Kogyo): 0.5mg/L

KCl (made by Wako Junyaku High School): 1 g/L

Cysteine (made by Wako Junyaku Kogyo): 0.2g/L

Distilled Water: The rest

(Mass-up so that the total amount became 1 L, and autoclaved at 121°C for 20 minutes.)

<Method of evaluating no bitter taste and good foam generation>

The dentifrice composition shown in the table was sensory evaluated for no bitterness and good foaming.

1 g of the toothpaste composition was applied to a toothbrush and brushed for 3 minutes to evaluate according to the following criteria. The absence of bitterness and good foaming were evaluated based on the following evaluation criteria from the average of 6 evaluators.

No bitter taste

Rating criteria

5: I do not feel the bitter taste

4: I hardly feel bitter taste

3: I feel a slightly bitter taste

2: feel bitter taste

1: I feel a strong bitter taste

Evaluation standard

◎: Average value is 4 points or more and 5 points or less

○: Average value is more than 3 points and less than 4 points

△: Average value is more than 2 points and less than 3 points

×: Average value is more than 1 point and less than 2 points

Good foaming

Rating criteria

5: foaming is very good

4: Some bubble outbreak is good

3: It is normal bubble generation

2: Some bubble outbreak is bad

1: bubble outbreak is very bad

Evaluation standard

◎: Average value is 4 points or more and 5 points or less

○: Average value is more than 3 points and less than 4 points

△: Average value is more than 2 points and less than 3 points

×: Average value is more than 1 point and less than 2 points

Details of the raw materials used are shown below.

(A) component

Sodium tetradecenesulfonic acid (sodium α-olefin (C14) sulfonic acid); manufactured by Lion Corporation

(B) component

(B-1) Sodium tripolyphosphate; manufactured by Taihei Chemical Industries, Ltd.

(B-1) Sodium pyrophosphate; Taihei Chemical Industry Co., Ltd. product

(B-1) Potassium pyrophosphate; manufactured by Taihei Chemical Industry Co., Ltd.

[Example II, Comparative Example II]

Compositions for oral cavity of the compositions shown in Tables 3 to 6 (Tables 3 and 4 are toothpaste compositions, and Tables 5 and 6 are oral rinse compositions) were prepared by the method shown below, and evaluated by the same method as described above. The results are recorded in Tables 3-6.

In addition, the absence of bitter taste and good foam generation of the mouthwash composition were sensory evaluated by the following method.

After 10 mL of the mouthwash was put in the mouth and rinsed for 20 seconds, the absence of bitter taste at the time of mouth washing was determined based on the above rating criteria. It evaluated based on the said evaluation criteria from the average of 6 evaluators.

A method of preparing a toothpaste composition;

First, after mixing a small water-soluble component such as sodium fluoride in purified water containing a viscous agent such as sorbitic solution at room temperature, the component (B-2) and the component (C) are further mixed with a binder, and Dispersed with. Powders such as the dispersion and abrasive were put in a kneader, and after mixing, a fragrance and component (A) were added. The inside of the kneader was depressurized to about 5 kPa, defoaming, and further mixing was continued to obtain a toothpaste composition.

A method of preparing a mouthwash composition;

In the preparation of the mouthwash composition, (A) component, (B-2) component, (D) component and other raw materials were sequentially added to purified water, stirred, and uniformly dissolved. In addition, a three-one motor (BL 1200, manufactured by HEIDON) was used for manufacturing.

The toothpaste composition and mouthwash composition of the comparative example were prepared according to the above method.

Details of the raw materials used are shown below.

(A) component

Sodium tetradecenesulfonate (α-olefin (C14) sodium sulfonate); manufactured by Lion Co., Ltd.

(B) component

(B-2) Palm oil fatty acid amide propylbetaine; 30% product (the amount in each case is pure powder value), TEGO Betain CK OK, manufactured by EVONIK Co., Ltd.

(B-2) Imidazolinium betaine; manufactured by Nikko Chemicals

(B-2) Aminoacetic acid betaine; Nikko Chemicals Co., Ltd. product

(C) Cetylpyridinium chloride; Wako Pure Chemical Industries, Ltd. product

(C) Benzalkonium chloride; Wako Pure Chemical Industries, Ltd. product

(C) Benzethonium chloride; manufactured by Nichiyu Corporation

(D) Xylitol; manufactured by Rocket Japan

(D) Erythritol; Wako Pure Chemical Industries, Ltd. product

As apparent from the results of the table, the oral biofilm removal effect was remarkably improved when (A) component and (B) component are used in combination. Also, the bitter taste was suppressed. In addition, oral compositions, especially toothpaste compositions, had moderate foaming.

Hereinafter, a prescription example is shown. In addition, the raw materials used are as described above.

[Prescription Example I-1] Mouthwash

(A) 0.8% of sodium tetradecenesulfonate

(B) (B-1) sodium tripolyphosphate 0.5

Polyoxyethylene (60) hydrogenated castor oil 0.3

Glycerin 5

Propylene glycol 4

(D) Xylitol 2

Sodium benzoate 0.2

Citric acid 0.02

Sodium citrate 0.2

Fragrance 0.2

Water rest

Total 100.0%

(A)/(B-1) ratio; 1.6

This mouthwash was excellent in oral biofilm removal effect, bitter taste was suppressed, and foam generation was good.

[Prescription Example II-1] Mouthwash

(A) 0.3% of sodium tetradecenesulfonate

(B) (B-2) Palm oil fatty acid amide propylbetaine 0.1

(D) Xylitol 1.5

(C) Cetylpyridinium chloride 0.05

Polyoxyethylene (60) hydrogenated castor oil 0.1

Glycerin 5

Propylene glycol 4

Methyl paraoxybenzoate 0.2

Sodium benzoate 0.2

Trisodium citrate 0.2

Fragrance 0.3

Water rest

Total 100.0%

(A)/(B-2) ratio; 3.0

This mouthwash was excellent in removing biofilm and suppressed bitter taste.

Claims (17)

An oral biofilm remover comprising (A) α-olefin sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2). The method of claim 1,
The oral biofilm remover, wherein the component (B) is a condensed phosphate (B-1), and (A)/(B-1) is 0.1 to 10 as a mass ratio. The method of claim 1,
(B) An oral biofilm remover, wherein the component is an amphoteric surfactant (B-2), and (A)/(B-2) is 0.2 to 8 as a mass ratio. The method of claim 1 or 3,
The amphoteric surfactant (B-2) is an oral biofilm remover, characterized in that at least one betaine-based amphoteric surfactant selected from fatty acid amide alkyl betaine, imidazolinium betaine, and amino acetate betaine. The method according to any one of claims 1 to 3,
The α-olefin sulfonate of component (A) is an α-olefin sulfonate having 14 to 16 carbon atoms. The method according to any one of claims 1 to 3,
(C) Oral biofilm remover, characterized in that it further comprises a quaternary ammonium salt. The method of claim 6,
The quaternary ammonium salt of the component (C) is an oral biofilm remover, characterized in that at least one selected from cetylpyridinium chloride, benzalkonium chloride and benzethonium chloride. The method according to any one of claims 1 to 3,
(D) An oral biofilm remover further comprising xylitol and/or erythritol. (A) α-olefin sulfonate, (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2), characterized in that it contains. The method of claim 9,
The composition for oral cavity (B) component is a condensed phosphate (B-1), and (A)/(B-1) is 0.1-10 as a mass ratio. The method of claim 9 or 10,
The oral cavity characterized in that the component (B) is a condensed phosphate (B-1) and contains 0.3 to 5% by mass of the α-olefin sulfonate as the component (A) and 0.1 to 5% by mass of the component (B-1) Dragon composition. The method of claim 9,
The composition for oral cavity (B) component is an amphoteric surfactant (B-2), and (A)/(B-2) is 0.2-8 as a mass ratio. The method of claim 9 or 12,
The component (B) is an amphoteric surfactant (B-2), and contains 0.1 to 3% by mass of the α-olefin sulfonate as the component (A) and 0.05 to 5% by mass of the component (B-2). Oral composition. The method according to any one of claims 9, 10, or 12,
(C) An oral composition comprising 0.003 to 0.05% by mass of a quaternary ammonium salt. The method according to any one of claims 9, 10, or 12,
(D) An oral composition containing 0.1 to 2% by mass of xylitol and/or erythritol further. The method according to any one of claims 9, 10, or 12,
Oral composition, characterized in that the toothpaste composition or mouthwash composition. The method according to any one of claims 9, 10, or 12,
Oral composition, characterized in that for removing oral biofilm.