JP2011256125A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an isopropyl methyl phenol-containing dentifrice composition that exhibits highly distributed bactericidal effect as biofilm bactericidal effect derived from the isopropyl methyl phenol, promptly reaching every hole and corner in an oral cavity.SOLUTION: The isopropyl methyl phenol-containing dentifrice composition contains (A) an anionic surfactant, (B) a wetting agent, (C) an organic thickener, and (D) isopropyl methyl phenol; and has a mass ratio (A)/(D) of 10-150. An aerosol dentifrice composition is obtained by filling an aerosol container with the isopropyl methyl phenol-containing dentifrice composition along with (E) a propellant.

Description

  The present invention relates to an aerosol dentifrice composition containing isopropylmethylphenol, which has an excellent bactericidal effect, particularly a dispersive bactericidal effect.

  Oral health is also a problem that should be addressed by each citizen, as it is taken up by the “National Health Promotion Movement in the 21st Century (Health Japan 21)”. Many oral diseases are thought to be caused by oral bacteria. For example, caries is streptococcus such as Streptococcus mutans, and periodontal disease is obligately anaerobic gram negative such as Porphyromonas gingivalis. It is an infectious disease caused by bacteria, mainly gonococcus In addition, oral malodor such as Fusobacterium nucleatum is involved in bad breath, which is cited by many as a problem related to the oral cavity. As an effective means for preventing and ameliorating these oral diseases, it is said that it is useful to control plaque, that is, keep the number of pathogenic bacteria in the oral cavity at a low level.

  As a means of reducing the number of pathogenic bacteria in the oral cavity, it is effective to add a bactericidal agent to oral care products. Among them, isopropylmethylphenol tends to have a broad antibacterial spectrum, and it is also in the oral biofilm. Since it has a characteristic that it has an excellent penetrability to other fungicides and has a bactericidal effect (biofilm bactericidal effect) against bacteria in a biofilm, it is blended in a dentifrice composition and marketed.

  However, a dentifrice composition such as toothpaste is usually a highly viscous paste, so dispersibility in the oral cavity is not sufficient, and the bactericidal component may not reach every corner of the oral cavity. In addition, in the dentifrice composition containing isopropylmethylphenol, it is difficult to satisfy and effectively exhibit the effects derived from isopropylmethylphenol to every corner of the oral cavity, and there is still room for improvement in this respect.

On the other hand, in order to improve the dispersibility of the dentifrice composition, it is known that the dentifrice composition is effective as an aerosol type preparation, and an isopropylmethylphenol-containing dentifrice composition is known as an aerosol type. If it is prepared, improvement of dispersibility in the oral cavity can be expected. However, it is difficult to achieve a high biofilm bactericidal effect derived from isopropylmethylphenol while maintaining good usability and appearance such as foam properties with an aerosol type dentifrice composition, and an aerosol type dentifrice composition There has never been an example in which isopropylmethylphenol was added to the product.
In addition, if the amount of isopropylmethylphenol added to the dentifrice composition is increased, the biofilm sterilization effect can be expected to be improved. In this case, however, the tasting taste derived from isopropylmethylphenol appears and the usability is reduced. was there.

  In order to improve the dispersibility of the dentifrice composition, techniques for making the dentifrice composition into an aerosol type have been proposed (see Patent Documents 1 and 2). In particular, Patent Document 1 discloses triclosan, chlorhexidine, cetylpyridinium chloride, and the like. Although there is a description that an antibacterial agent may be used in combination, these dentifrice compositions do not provide sufficient penetration and bactericidal effects on oral biofilms. In addition, these patent documents do not show that isopropylmethylphenol is added to an aerosol type dentifrice composition.

  Patent Document 3 proposes a cosmetic composition in which a cationic thickener and a compound having antiperspirant, refreshing or astringent action are blended, and isopropylmethylphenol and carboxymethylcellulose are added to an aerosol-type skin cosmetic. The blended composition is described. However, this is a technique related to cosmetics that is used on the skin and gives a good feel with excellent salt resistance and no stickiness, and this composition contains surfactants and polyols such as polyhydric alcohols and sugar alcohols. It is not used and is sprayed on the skin in a mist. From patent document 3, the improvement technology of the intraoral dispersibility of an isopropylmethylphenol containing dentifrice composition and oral biofilm bactericidal power cannot be estimated.

  Thus, isopropylmethylphenol is useful as a bactericidal component in dentifrice compositions because of its broad antibacterial spectrum and excellent permeability to oral biofilms. It has been difficult in the prior art to blend and quickly reach every corner of the oral cavity while maintaining good usability and appearance stability of the preparation and exhibiting a high disinfection effect. Accordingly, an isopropylmethylphenol-containing dentifrice that has excellent dispersibility of isopropylmethylphenol in the oral cavity and has a high disinfection and bactericidal effect capable of satisfying and effectively exhibiting the effect derived from isopropylmethylphenol to every corner of the oral cavity. Development of a composition is highly desired.

Special table 2008-518927 JP-T-2006-500329 JP 2005-239633 A JP 2000-178155 A

  The present invention has been made in view of the above circumstances, and an isopropylmethylphenol-containing dentifrice composition that achieves a high disinfection effect by rapidly reaching to every corner of the oral cavity the biofilm sterilization effect derived from isopropylmethylphenol. The purpose is to provide.

  As a result of intensive studies to achieve the above object, the present inventors have (A) an anionic surfactant, (B) a wetting agent, (C) an organic thickener, and (D) isopropyl. An isopropylmethylphenol-containing dentifrice composition containing methylphenol and having a mass ratio of (A) / (D) of 10 to 150 is filled into an aerosol container together with (E) a propellant, thereby The inventors have found that isopropylmethylphenol is rapidly dispersed in the oral cavity while maintaining good usability and appearance stability, and the present invention has been achieved.

  According to the present invention, there is provided a dentifrice composition containing an anionic surfactant, a wetting agent, an organic thickener, and isopropylmethylphenol, and having an appropriate mass ratio between the anionic surfactant and isopropylmethylphenol. By filling an aerosol container together with a propellant, the above problem can be solved unexpectedly and isopropylmethylphenol can be effectively blended into an aerosol type preparation, and the usability such as foam performance and appearance stability are good. Moreover, it disperses well in the oral cavity, and the steric methylphenol-derived oral biofilm sterilization effect can quickly reach every corner of the oral cavity, thereby exhibiting a high dispersion sterilization effect. Here, the disinfecting and bactericidal effect means that when the dentifrice composition is placed on a toothbrush or the like and applied to the oral cavity, the bactericidal component in the dentifrice composition is quickly dispersed to every corner of the oral cavity. This is an effect of exerting a bactericidal effect.

  The applicant has proposed a technique for a toothbrush sanitizing foam agent that contains a surfactant and ethanol and is used by filling an aerosol or non-aerosol type foaming container (see Patent Document 4). However, this is for the purpose of disinfecting and cleaning toothbrushes, and it contains triclosan, cetylpyridinium chloride, etc. as a bactericidal agent, and is a technique different from the present invention. In any case, surfactant and isopropylmethylphenol Therefore, it does not suggest an appropriate blending ratio and the effects of the present invention. From Patent Document 4, it is impossible to predict a technique for improving the dispersibility of the isopropylmethylphenol-containing dentifrice composition and the bactericidal power of the oral biofilm.

  In the present invention, it is more effective to use liquefied gas as the propellant (E) because uniform foam can be discharged until the end when the dentifrice composition in the container is used up.

  In the present invention, (F) a betaine surfactant can be further added to the dentifrice composition. By blending the component (F), it is possible to further improve the retention of foam when sprayed from an aerosol container, and it becomes easier to brush with a toothbrush, so that isopropylmethylphenol can be effectively applied to the oral cavity. Higher dispersal sterilization effect is exhibited.

In the present invention, one or more perfume ingredients selected from (G) 3-octanol, 3-octyl acetate, 3-octanone and Fencon can be further added to the dentifrice composition. By blending the component (G), it is possible to effectively mask the unpleasant taste derived from isopropylmethylphenol, and to improve the taste of the preparation well. The high dispersibility bactericidal effect derived from isopropylmethylphenol can be expressed in the oral cavity while simultaneously maintaining good properties and feeling of use.
In addition, since the fragrance | flavor component of (G) component has characteristic fragrance | flavor and is used in preparation flavors, such as cheese, a trace amount, it is an unpleasant fragrance itself, Therefore Although the use as a fragrance was limited, when the component (G) was added to the dentifrice composition according to the present invention in combination with isopropylmethylphenol, it was surprisingly enough to sufficiently suppress the odor derived from isopropylmethylphenol. Therefore, it is possible to obtain a preparation having a good feeling of use while exhibiting a high dispersibility bactericidal effect while maintaining good usability and appearance of the preparation.

  Furthermore, in this invention, it is preferable to mix | blend (H) anisaldehyde in addition to the specific fragrance | flavor component of the said (G) component, By adding together (G) and (H) component to a dentifrice composition. The masking effect of the unpleasant taste derived from isopropylmethylphenol can be further enhanced.

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
(A) an anionic surfactant,
(B) a wetting agent,
An isopropylmethylphenol-containing dentifrice composition containing (C) an organic thickener and (D) isopropylmethylphenol and having a mass ratio of (A) / (D) of 10 to 150 is (E) injection An aerosol dentifrice composition, which is filled in an aerosol container together with an agent.
Claim 2:
The aerosol dentifrice composition according to claim 1, wherein (B) the wetting agent is a combination of glycerin, sorbit and polyethylene glycol having an average molecular weight of 190 to 630.
Claim 3:
(E) The aerosol dentifrice composition according to claim 1 or 2, wherein the propellant is a liquefied gas.
Claim 4:
The aerosol dentifrice composition according to any one of claims 1 to 3, further comprising (F) a betaine-type surfactant.
Claim 5:
Furthermore, (G) 1 type, or 2 or more types of fragrance | flavor components chosen from 3-octanol, 3-octyl acetate, 3-octanone, and Fencon are contained, The any one of Claims 1 thru | or 4 characterized by the above-mentioned. Aerosol dentifrice composition.
Claim 6:
The aerosol dentifrice composition according to claim 5, further comprising (H) anisaldehyde.

  According to the present invention, isopropylmethylphenol can be effectively blended in an aerosol type dentifrice composition, the usability and appearance of the preparation can be maintained well, and it is quickly dispersed in the oral cavity and derived from isopropylmethylphenol. A high biofilm sterilizing effect is exhibited in every corner of the oral cavity. The aerosol dentifrice composition of the present invention can disperse rapidly to every corner of the oral cavity and effectively sterilize the oral biofilm, and is effective in preventing or improving oral diseases such as periodontal disease. Furthermore, in the present invention, the retention of foam can be further improved by blending (F) a betaine type surfactant, and the blending of the specific perfume component of (G) component, particularly the (G) component. (H) By blending together with anisaldehyde, it is possible to effectively mask the tasting taste derived from isopropylmethylphenol, and to obtain a preparation with more excellent characteristics.

  Hereinafter, the present invention will be described in more detail. The aerosol dentifrice composition of the present invention contains (A) an anionic surfactant, (B) a wetting agent, (C) an organic thickener, and (D) isopropylmethylphenol, and (A) / ( An isopropylmethylphenol-containing dentifrice composition in which D) is an appropriate ratio is filled in an aerosol container together with (E) a propellant.

  (A) As an anionic surfactant, the 1 type (s) or 2 or more types of anionic surfactant normally mix | blended with a dentifrice composition can be selected suitably, and can be used.

  Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine and sodium myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, lauryl Examples include sodium sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, and the like. Of these, alkyl sulfates and acyl sarcosine salts, particularly sodium lauryl sulfate, are more preferred in terms of solubilizing ability of oil-soluble components, oral mucosal irritation, and taste.

  (A) The compounding amount of the anionic surfactant is 0.8 to 5% (mass%, the same applies hereinafter) of the whole composition from the viewpoints of foamability, solubilizing ability of oil-soluble components and oral mucosal irritation. In particular, 1.0 to 4% is preferable. If the blending amount is less than 0.8%, the foaming amount may be insufficient, or the solubilizing ability of oil-soluble components such as isopropylmethylphenol and fragrance components may be insufficient. If the micelles are too rigid and isopropylmethylphenol is difficult to be released from the micelles at the target site and a sufficient disinfection effect is not obtained, or the foaming amount is too much to hinder use, bitterness and oral cavity May cause irritation to mucous membranes.

  (B) As the wetting agent, one or more of polyhydric alcohol, sugar alcohol and the like can be appropriately selected and used. Specific examples include glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 190 to 6,000, 1,3-butylene glycol, xylitol, maltitol, lactitol, erythritol, palatinose, trehalose, and the like. Sorbit, propylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630 are preferable in terms of drying prevention effect, taste, and effective expression of sterilizing power against biofilm sterilization of isopropylmethylphenol. The average molecular weight of the polyethylene glycol according to the present invention is the average molecular weight described in the Quasi-drug Raw Material Standard 2006.

  Examples of polyethylene glycol having an average molecular weight of 190 to 6,000 include polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 300 (average molecular weight 280 to 320), polyethylene glycol 400 (average molecular weight 380 to 420), polyethylene glycol 600 ( Depending on the product, for example, polyethylene glycol # 200, there may be a # between the polyethylene glycol and the numerical value.

  Although (B) component can be used individually by 1 type or in combination of 2 or more types, it is more preferable to use 2 or more types from the point of the taste at the time of use. In particular, when sorbit and glycerin are used in combination, the retention of the preparation in the oral cavity is enhanced, the disinfection action is effectively exerted, and the stickiness of the preparation can be suppressed, both of them and polyethylene glycol having an average molecular weight of 190 to 630 A combination of these three is preferred.

  (B) The blending amount of the wetting agent is preferably 30 to 70%, particularly preferably 40 to 60% of the entire composition from the viewpoint of drying prevention and dispersibility of the dentifrice composition. If the blending amount is less than 30%, the dentifrice composition may be insufficiently dried and solidified at the opening of the container, resulting in clogging. If the blending amount exceeds 70%, the viscosity will increase. In some cases, the dispersibility becomes low, sufficient foamability cannot be obtained, and sufficient dispersibility can not be obtained.

  (C) Specific examples of the organic thickener include xanthan gum, sodium polyacrylate, carrageenan, sodium alginate, propylene glycol alginate, carboxyvinyl polymer, tragacanth gum, guar gum, hydroxypropyl guar gum, tara gum, locust bean gum, caraya gum, Quince seed gum, tamarind gum, carboxymethylcellulose sodium, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cellulose, gellan gum, gelatin, curdlan, gum arabic, agar, pectin, sodium caseinate, polyvinyl alcohol, pullulan, etc. One or two or more of these can be appropriately selected and used. Among these, xanthan gum and sodium alginate are particularly preferable in terms of foam retention.

  (C) The blending amount of the organic thickener is preferably 0.15 to 0.4%, particularly preferably 0.2 to 0.35% of the total composition from the viewpoint of foam retention and dispersibility. If the blending amount is less than 0.15%, the foam retention may be inferior, and if it exceeds 0.4%, the viscosity becomes high and the dispersibility becomes low, and sufficient dispersibility may not be obtained.

  (D) Isopropylmethylphenol is 1-hydroxy-4-isopropyl-3-methylphenol, and a commercially available product can be used. For example, it is available from Osaka Kasei Co., Ltd. under the trade name isopropylmethylphenol.

  (D) The blending amount of isopropylmethylphenol is preferably 0.01 to 0.2% of the whole composition, particularly 0.02 to 0.1% from the viewpoint of the disinfection and sterilization effect and tastelessness. If it is less than 0.01%, a sufficient dispersive sterilizing effect may not be exhibited, and if it exceeds 0.2%, an unpleasant taste may be caused.

  In the present invention, from the viewpoint of foamability and dispersibility, the mass ratio of (A) anionic surfactant to (D) isopropylmethylphenol ((A) / (D)) is 10 to 150, preferably 15-80. When the mass ratio is less than 10, most of the surfactant is used for solubilization of the oil-soluble component, so that sufficient foaming property cannot be obtained, and when it exceeds 150, isopropylmethylphenol incorporated in the micelle of the surfactant. May not be released at the target site, and the dispersive and sterilizing effect may not be sufficiently exerted, or the foaming amount may be too large, resulting in a problem in usability.

  In addition to the components (A) to (D), the dentifrice composition of the present invention further comprises (F) a betaine surfactant, (G) 3-octanol, 3-octyl acetate, 3-octanone, and Fencon. The selected fragrance component, (H) anisaldehyde, can be blended.

In the present invention, the retention of foam can be further improved by blending the (F) betaine type amphoteric surfactant.
As component (F), lauryldimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoli Examples thereof include nium betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, and coconut oil fatty acid amidopropyl betaine, and imidazolinium betaine type and amidopropyl betaine type are particularly preferable in terms of taste.
Specifically, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine (Enadicol C-40H, manufactured by Yushi Kogyo Co., Ltd.), lauryl diaminoacetic acid betaine (SWANOL AM-301, Nippon Surfactant) Kogyo Co., Ltd.) and palm oil fatty acid amidopropyl betaine (TEGO BETAIN CK-OK, manufactured by Degussa) can be used.

(F) When mix | blending a betaine type surfactant, the compounding quantity is 0.01 to 0.5% of the whole composition from the point of foam retention, Especially 0.05 to 0.3% is preferable. If the blending amount is less than 0.01%, sufficient foam retention improvement effect may not be obtained. If the blending amount exceeds 0.5%, the amount of foaming increases so that the usability deteriorates and bitterness occurs. Sometimes.
In addition, when mix | blending (F) component, the mass ratio of ((A) + (F)) / (D) is desirable in the range of 10-150.

In the present invention, as the component (G), one or more perfume ingredients selected from 3-octanol, 3-octyl acetate, 3-octanone, and Fencon can be blended. By blending the fragrance component of component (G), it is possible to effectively mask the taste that is derived from isopropylmethylphenol.
When combining 2 or more types of the said fragrance | flavor components, the combination of 3-octanol, 3-octyl acetate, and / or Fencon is suitable.
In addition, even if it is octanol, 1-octanol common as a fragrance | flavor of a dentifrice composition does not have an effect which masks the taste taste derived from isopropylmethylphenol.

  As the component (G), commercially available products can be used. For example, 3-octanol is a product of Shiono Perfume Co., Ltd., 3-octyl acetate and 3-octanone are products of Inoue Perfume Co., Ltd., and Fencon is Products from Koei Kogyo Co., Ltd. can be used.

  (G) When mix | blending component, the total compounding quantity is 0.0001 to 0.1% of the whole composition, 0.0005 to 0.05% especially 0.001 to 0.02% is desirable. If the blending amount is less than 0.0001%, the isopropyl methylphenol-derived taste may not be satisfactorily masked, and if it exceeds 0.1%, the flavor derived from the fragrance component may be too strong and cause taste inequality.

  In this invention, the anisaldehyde of (H) component is further added with the fragrance | flavor component of (G) component, and the masking effect of the unpleasant taste derived from isopropylmethylphenol is mix | blended combining (G) and (H) component. Can be further increased.

  (H) As anisaldehyde, commercial items, such as a product of Taiyo Perfume Co., Ltd., can be used. The amount of anisaldehyde added is preferably 0.0001 to 0.1%, particularly 0.001 to 0.02% of the total composition. If the blending amount is less than 0.0001%, the masking effect of taste tasting may not be sufficiently enhanced. If it exceeds 0.1%, the flavor of anisaldehyde itself is too strong as in the case of component (G), so May occur.

  Further, the blending amount of (H) anisaldehyde is such that the total blending amount of the (G) component and the (H) component is 0.0002 to 0 of the entire composition from the viewpoint of further enhancing the taste-masking effect derived from isopropylmethylphenol. .15%, particularly within a range of 0.002 to 0.03% is desirable. If the total blending amount is less than 0.0002%, the masking effect of unpleasant taste may not be sufficiently increased. If it exceeds 0.15%, the flavors of the components (G) and (H) themselves are strongly expressed. Disgusting may occur.

  As the combination of the (G) component and the (H) component, a combination of 3-octanol and anisaldehyde is particularly preferable, and thereby an especially excellent masking effect is exerted against an unpleasant taste derived from isopropylmethylphenol. The

  The dentifrice composition of the present invention can contain other known additives as optional components in addition to the above components. For example, (A) surfactants other than anionic surfactants and (F) betaine surfactants, inorganic thickeners, abrasives, sweeteners, preservatives, (D) various active ingredients other than isopropylmethylphenol, A coloring agent, a fragrance other than the component (G) and the <H> component, a solvent, and the like can be blended within a range that does not interfere with the effects of the present invention, and these components and water can be mixed and manufactured.

  Examples of surfactants other than anionic and betaine types include nonionic surfactants and cationic surfactants, and those usually used in dentifrice compositions can be used. Specifically, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl glucoside, decaglyceryl laurate , Alkylammonium, alkylbenzylammonium and the like. The total amount of these surfactants including the components (A) and (F) is preferably in the range of 1 to 5% of the entire dentifrice composition.

  Examples of the inorganic thickener include thickening silica, bee gum, smectite, laponite, montmorillonite, bentonite and the like (the amount is usually 0 to 8%, particularly 0.1 to 8% when blended).

  As abrasives, silica gel, precipitated silica, aluminosilicate, zirconosilicate, amorphous anhydrous silicic acid, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrous, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate , Calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zeolite, polymethyl methacrylate, nylon powder, silk powder, cellulose powder , Glucomannan and the like (usually 0 to 10%, particularly 0.1 to 10% when blended).

  Sweeteners include saccharin sodium, stevioside, stevia extract, glycyrrhizin, perilartin, thaumatin, neohesperidyl hydrochalcone, paramethoxycinnamic aldehyde, asparatylphenylalanine methyl ester, acesulfame potassium, sucralose, sucrose, glucose, dextrose, invert sugar, Fructose, oligosaccharide, reduced starch syrup, aspartame and the like can be blended.

  Examples of the preservative include paraoxybenzoic acid esters such as methyl paraben, butyl paraben, and ethyl paraben, benzoic acid or a salt thereof, salicylic acid or an ester or a salt thereof, and the like.

  As an active ingredient, in addition to isopropylmethylphenol, other active ingredients may be blended within a range not impeding the effects of the present invention. For example, bactericides such as triclosan, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, decalinium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, dodecyldiaminoethylglycine, fluorine such as sodium fluoride, sodium monofluorophosphate, tin fluoride Compounds, antiplasmin agents such as tranexamic acid, epsilon aminocaproic acid, ascorbic acid and its derivatives, tocopherol and its derivatives, riboflavin, pyridoxine hydrochloride, cyanocobalamin, β-carotene, ergocalciferol, vitamins such as menadione, ubiquinone, glycyrrhizic acid Salts, glycyrrhetinic acid, allantoins, buckwheat, auren, rosemary, clove, sage, thyme, oxon, touki, hamamelis, Plant extracts such as wa, green tea, ginkgo, hawthorn, hop, walrus, hypericum, oolong tea, linden, acacia, rose, dodami, horsetail, black tea, peonies, birch, hawthorn, maronier, mallow, dextranase, mutanase, Enzymes such as lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, potassium nitrate, sodium tripolyphosphate, sodium pyrophosphate, γ-oryzanol, dihydrocholesterol, α-bisabolol, azulene, methoxyethylene / maleic anhydride copolymer, trichloro Carbanilide, alanine, glycine, proline, L-arginine, sodium L-aspartate, trimethylglycine, copper chlorophyllin sodium, copper gluconate, chlorous acid , Zinc citrate, zeolite, water-soluble inorganic phosphoric acid compounds, aluminum lactate, sodium chloride, and the like can be compounded alone or in combination.

  As colorants, red 2, red 3, yellow 4, yellow 5, blue 1, blue 2, green 3, and other legal dyes, safflower dye, gardenia dye, cochineal dye, anato dye, mica Examples thereof include titanium, titanium oxide, and bengara.

  As the fragrance, a fragrance other than the component (G) and the component (H) may be added. For example, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, peppermint oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil, lime oil , Grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, lemongrass oil, Rose oil, jasmine oil, patchouli oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchouli absolute, ginger oleoresin, pepper oleoresin, capsicum oleoresin Natural fragrances such as pepper extract, and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and limonene, pinene, Butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linalool, α-terpineol, l-menthol, benzyl alcohol, phenylethyl alcohol, anethole, thymol, methylchavicol, eugenol, carvone, Mentone, Pregon, 1,8-Cineol, Yonon, Caron, n-Hexanal, trans-2-Hexenal, Citral, Cinnamaldehyde, Benzaldehyde, Ethyl Acetate, Ethyl Butyrate, Isoamyl Acetate, Hexyl Acetate, Ethi 2-Methylbutyrate, allylhexanoate, allylcyclohexanepropionate, linalyl acetate, menthyl acetate, menthyl lactate, carbyl acetate, phenoxyethyl isobutyrate, methyl jasmonate, methyl salicylate, ethyl salicylate, methylcinna Mate, methyl anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, ambletlide, dimethyl sulfide, trimethylpyrazine, ethyl β-methylthiopropionate, furaneol, Ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propionic acid, p-methoxycinnamic aldehyde, 3-l-mentoxip Individual flavors such as bread-1,2-diol, menthone glycerin acetal, spiranthol, monomenthyl succinate, linalool oxide, vanillyl butyl ether, isopulegol, strawberry flavor, apple flavor, melon flavor, banana flavor, peach flavor, raspberry Flavors, pineapple flavors, grape flavors, tropical fruit flavors, mango flavors, ume flavors, orange flavors, lemon flavors, grapefruit flavors, tea flavors, butter flavors, milk flavors, etc., and ethyl alcohol, triacetin, glycerin fatty acid esters Combined with known fragrance materials used in dentifrice compositions, such as fragrance solvents Can be used. Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for perfume using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a composition.

  Examples of the solvent include purified water, ethanol that has not been modified or modified with a fragrance, and the like.

In the present invention, a stock solution of a dentifrice composition containing the above components (a stock solution refers to a mixture obtained by degassing and mixing all components blended in a dentifrice composition other than the component (E) (hereinafter the same). )) Is filled into an aerosol container together with (E) propellant and prepared as an aerosol type formulation.
(E) As a propellant, well-known liquefied gas and compressed gas can be used as a propellant of an aerosol formulation, and 1 type (s) or 2 or more types can be selected suitably and can be used. Specific examples include dimethyl ether, liquefied petroleum gas, propane, isobutane, normal butane, isopentane, carbon dioxide, nitrogen, and nitrous oxide.
Here, the compressed gas refers to a gas having a gauge pressure of 1 MPa or more at a normal temperature or 35 ° C. according to the provisions of the High Pressure Gas Safety Law. The liquefied gas generally refers to a gas that has been pressurized or cooled to become a liquid. In the high-pressure gas safety method, it is actually a liquid and has a pressure of 0.2 MPa or more at ordinary temperatures, or The temperature at which the pressure becomes 0.2 MPa is defined as a temperature of 35 ° C. or lower, but in the present invention, the vapor pressure at 20 ° C. is preferably 0.2 to 1.2 MPa. Among these gases, liquefied gas is preferable because a constant pressure can be obtained until the end, and dimethyl ether, isopentane, and liquefied petroleum gas are particularly preferable. Among them, dimethyl ether is preferable in terms of compatibility with water and taste.

  In the present invention, the blending ratio (mass ratio) of the stock solution of the dentifrice composition and the propellant is preferably from 85:15 to 99: 1, particularly 90:10 to 98: 2, as the stock solution: propellant. If the proportion of the stock solution is too large and the blending ratio exceeds 99: 1, the propellant will be relatively small, and the amount of foaming will be small, so that the dispersion will be insufficient and sufficient disinfectant sterilization properties may not be obtained. Yes, if the proportion of the undiluted solution is too small and the blending ratio is less than 85:15, the propellant becomes relatively large and the expansion rate when discharged from the container is high, so the foaming amount is too large and the usability May cause problems. When the propellant is only liquefied gas, it is preferable that the propellant content is 3% or more and the blending ratio is 97: 3 or less, particularly 4% or more and the blending ratio is 96: 4 or less.

  The aerosol container filled with the dentifrice composition is a high-pressure gas safety method that encloses liquefied gas or concentrated gas as a propellant together with the contents in a pressure-resistant container, and injects the contents in a foam state during use to make an aerosol. A known aerosol container that satisfies the conditions defined in (1) can be used. Specific examples include tin can seam welded cans, tin seamless cans, aluminum monoblock cans, glass containers, plastic containers, and the like.

  In the method of applying the aerosol dentifrice composition of the present invention to the oral cavity, for example, a foam composition ejected from an aerosol container at the time of use is placed on a toothbrush, and the tooth is brushed by a normal method using this. In addition to the toothbrush, a sponge brush or a cotton swab may be used.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In addition, in the following examples, all compounding quantities are the mass%, and showed it with the quantity converted into the pure part.

For preparing these dentifrice compositions, sodium lauryl sulfate (manufactured by Toho Chemical Co., Ltd.), sodium lauroyl sarcosine (manufactured by Kawaken Fine Chemical Co., Ltd.), sodium cocoyl methyl taurine (Diapon K-SF, Nippon Oil & Fats Co., Ltd.) )), 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (Enadicol C-40H, manufactured by Yushi Kogyo Co., Ltd.), lauryl diaminoacetic acid betaine (SWANOL AM-301, Nippon Surfactant Industries, Ltd.) Co., Ltd.), palm oil fatty acid amidopropyl betaine (TEGO BETAIN CK-OK, manufactured by Degussa), polyoxyethylene (5) stearyl ether (manufactured by Lion Chemical Co., Ltd.), polyoxyethylene (20) hydrogenated castor oil (NIKKOL HCO-20, Nikko ke Mikals Co., Ltd.), xanthan gum (Monato Gum DA, CP Kelco Co., Ltd.), sodium alginate (Kimika Algin, manufactured by Kimika Co., Ltd.), propylene glycol (manufactured by Asahi Glass Co., Ltd.), sorbite solution (70% aqueous solution, NEOSORB 70 / 02B, manufactured by ROQUETTE, glycerin (85% aqueous solution, manufactured by Lion Corporation), polyethylene glycol 400 (PEG # 400, manufactured by Lion Chemical Co., Ltd.), polyethylene glycol 300 (Toho Polyethylene Glycol 300, Toho Chemical Industry Co., Ltd.) ), Isopropylmethylphenol (Osaka Kasei Co., Ltd.), dimethyl ether (DME, Taiyo Liquefied Gas Co., Ltd.), isopentane (Ocean Liquefied Gas Co., Ltd.), carbon dioxide (experimental gas “carbon dioxide”) , Manufactured by Nakamura Science Co., Ltd.), nitrogen ( Joto Nippon Acid Co., Ltd.), 3-octanol (Shiono Fragrance Co., Ltd.), 3-octyl acetate (Inoue Fragrance Co., Ltd.), 3-octanone (Inoue Fragrance Co., Ltd.), Fencon (manufactured by Koei Kogyo Co., Ltd.), anisaldehyde (manufactured by Taiyo Fragrance Co., Ltd.), and 1-octanol (manufactured by Takasago Fragrance Co., Ltd.) were used. As for other ingredients, silica, thickening silica, saccharin sodium, titanium oxide, purified water are makeup standard (cosmetic raw material standard) standard products, sodium fluoride and sodium polyphosphate are quasi-standard (quasi-drug raw material standard) standard products Potassium nitrate used was a food additive standard product, and Red 226 and Blue No. 1 used legal dye standard products.
The fragrance | flavors prepared and used the fragrance | flavor composition AI of the composition shown to Tables 6-12. In addition, 3-octanol, 3-octyl acetate, 3-octanone, Fencon, and anisaldehyde are not included in the following fragrance compositions A to I.

[Examples and Comparative Examples]
After preparing the stock solution by degassing and mixing the raw materials of the dentifrice composition with the compositions shown in Tables 1 to 5, about 50 g of this was filled in a glass aerosol test bottle (70 mL size), and the stock solution shown in the table: An aerosol dentifrice composition was prepared by encapsulating the propellant of component (E) in the proportion (mass ratio) of the propellant. In addition, the compounding quantity of purified water was adjusted so that it might become 100% with respect to the whole undiluted | stock solution. The aerosol dentifrice composition was evaluated by the following method. The results are shown in Tables 1-5.

Experiment 1: Evaluation of foamability The button of the aerosol container was pressed for 3 seconds to discharge the preparation (dentifrice composition), and the foamability was visually evaluated according to the following criteria.
◎: Foamed well and the amount of foaming was appropriate ○: Foamed slightly well, or slightly foamed, but at a level where there was no problem in use
△: Not much foaming or a large amount of foaming at a slightly problematic level
Yes ×: It did not foam or was too difficult to use due to too much foaming

Experiment 2: Evaluation of foam retention The button of the aerosol container was pressed for 3 seconds to discharge the preparation, and the foam retention was visually evaluated according to the following criteria. It was judged that the foam retention was high when the foam was retained for 5 seconds or more.
◎: Bubbles were held for 30 seconds or more ○ to ◎: Bubbles were held for 20 seconds to less than 30 seconds ○: Bubbles were held for 5 seconds to less than 20 seconds Δ: Bubbles were 1 second to 5 seconds Disappeared in less than ×: Bubbles disappeared in less than 1 second or did not foam

Experiment 3: Evaluation of dischargeability The button of the aerosol container was repeatedly pressed to discharge the preparation until the contents disappeared, and the foamed state was visually evaluated according to the following criteria. Those with a score of ○ or ◎ were judged to have good discharge characteristics.
◎: A constant foaming was obtained until the end, and it was possible to discharge until the end. ○: The foaming was slightly weakened from the middle, but could be discharged to the end. Did not discharge ×: Did not discharge from the beginning

Experiment 4: Evaluation of anti-drying property 2 g of the dentifrice composition stock solution was placed in a 50 mL beaker, spread over the entire bottom surface, allowed to stand at room temperature for 1 day, the mass reduction rate was measured, and evaluated according to the following criteria. Those having a reduction rate of less than 45% were judged to have high drying prevention properties.
◎: Reduction rate of less than 35% ○: Reduction rate of 35% or more and less than 45% △: Reduction rate of 45% or more and less than 50% ×: Reduction rate of 50% or more

Experiment 5: Evaluation of solubility of oil-soluble component After taking the stock solution of the dentifrice composition in a polyethylene terephthalate bottle (capacity 80 mL) and accelerated degradation for one month in a constant temperature bath at 40 ° C, Separation was assessed visually.
◎: Separation of oil-soluble components was not observed ○: Separation of oil-soluble components was hardly observed, and there was no problem ×: Separation of oil-soluble components was observed

Experiment 6: Evaluation of dispersive bactericidal power Using the biofilm bactericidal power of the liquid in which the preparation was naturally dispersed as an index, the dispersible bactericidal power of the dentifrice composition in the oral cavity was evaluated by the following method.
A 7 mm diameter hydroxyapatite (HA) plate was treated with human unstimulated saliva filtered through a 0.45 μm filter for 4 hours, and Streptococcus mutans, Actino in trypticase soy broth to which hemin and menadione were added. Cultivated by Actinomyces naeslundii, Bayonella parvula, Fusobacterium nucleatum, and Porphyromonas genivaris on Porphyromonas spp. A model biofilm was formed. The dentifrice composition is discharged from the aerosol container, 5 g of the dentifrice composition is taken in the center of a 30 mL size beaker, and artificial saliva (50 mmol / L KCl + 1 mmol / L KH ₂ PO ₄ +1 mmol / L CaCl) heated to 37 ° C. ₂ +0.1 mmol / L MgCl ₂ (pH 7.0)) 10 mL was added and allowed to disperse naturally. After 20 seconds, the tip of the pipette was inserted 7 mm inside the beaker wall surface, and the dispersion was collected. It was. The model biofilm was immersed in this test drug solution for 3 minutes once a day after culturing for 2 weeks and further cultured for 3 days (n = 5). At the end of the culture, the model biofilm was taken out, dispersed, and cultured on an agar plate to determine the number of viable bacteria of each bacterial species in the model biofilm. Although the number of viable bacteria may fluctuate somewhat depending on the culture conditions, when artificial saliva is used instead of the test drug, it is about 8.5 log cfu (colony forming units / HA plate), less than 6.0 log cfu / HA plate In this case, it was judged that the biofilm dispersion sterilization power was high.
Judgment criteria:
A: Less than 5.0 log cfu / HA plate B: More than 5.0 log cfu / HA plate and less than 6.0 log cfu / HA plate Δ: 6.0 log cfu / HA plate and more than 7.0 log cfu / HA plate ×: 7. More than 0log cfu / HA board

Experiment 7: Evaluation of tastelessness A sensory test was performed using 10 expert panelists. About 0.3 g of the preparation was placed on a commercial toothbrush and brushed for 3 minutes, and the unpleasant taste felt during use was evaluated according to the following rating. An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ○ were ensured according to the following criteria were judged to be a dentifrice composition with no taste.
(Score)
4 points: no disgusting 3 points: little disgusting 2 points: slightly disgusting 1 point: disgusting (evaluation criteria)
◎: 3.7 points to 4.0 points ◎ to ○: 3.3 points to less than 3.7 points ○: 3.0 points to less than 3.3 points Δ: 2.0 points to 3 points Less than 0 point x: Less than 2.0 point

注：原液とは、（Ｅ）成分以外の、歯磨剤組成物に配合される全成分を脱気混合したもの（以下、同様。）。

Note: The stock solution is a mixture obtained by degassing and mixing all components blended in the dentifrice composition other than the component (E) (the same applies hereinafter).

注：比較例１は、均一な製剤を調製することができなかったため、発泡性、泡保持性、排出性、分散殺菌力の評価ができなかった。比較例４は、製剤を容器から吐出することができなかったため、発泡性、泡保持性、排出性の評価はできなかった。なお、比較例４の分散殺菌力（＊）については、充填前の原液を用いて行った評価結果である。従って、本発明のエアゾール歯磨剤組成物は、エアゾールではない原液に比べて、口腔内で高い分散殺菌力を奏することがわかった。

Note: In Comparative Example 1, since a uniform preparation could not be prepared, evaluation of foamability, foam retention, dischargeability, and dispersibility was not possible. In Comparative Example 4, since the preparation could not be discharged from the container, evaluation of foamability, foam retention, and dischargeability could not be performed. In addition, about the dispersal sterilization power (*) of the comparative example 4, it is the evaluation result performed using the undiluted | stock solution before filling. Therefore, it was found that the aerosol dentifrice composition of the present invention exhibits a high dispersal sterilization power in the oral cavity as compared with a stock solution that is not an aerosol.

From the results of Tables 1 and 2, when the composition lacking the components (A) to (D) according to the present invention, the composition with an inappropriate mass ratio of (A) / (D), or the component (E) is missing Inferior in foaming properties, foam retention properties, discharge properties, drying prevention properties, solubility of oil-soluble components, and dispersive sterilizing power, satisfactory effects could not be obtained, or formulation could not be achieved. On the other hand, it was confirmed that the composition of the present invention is excellent in all these characteristics, has a high bactericidal effect on the oral biofilm, and exhibits an excellent disinfection power.
From the results of Table 3, it was confirmed that the sustainability of the foam was further improved by adding the component (F) in addition to the components (A) to (D). In addition, from the results of Tables 4 and 5, it is possible to effectively mask the tasting taste derived from isopropylmethylphenol by further blending the component (G), and the masking effect of the tasting taste by using the components (G) and (H) together. Was confirmed to increase.
In addition, the same result was obtained even if the fragrance composition A was replaced with any of the fragrance compositions B to I.
A prescription example is shown below. In addition, the thing similar to the above was used for the compounding component and the aerosol test bottle.

[Formulation Example 1] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 300 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.25
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Sodium tripolyphosphate 1
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Red No. 226 0.001
Blue No. 1 0.001
Titanium oxide 0.4
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution of the dentifrice composition having the above composition was filled in an aerosol test bottle, and the component (E) (propellant) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95%
(E) Isopentane 3
Carbon dioxide 2
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 2] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 400 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.25
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Potassium nitrate 9.3
Sodium tripolyphosphate 1
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Titanium oxide 0.4
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95%
(E) Isopentane 3.5
Carbon dioxide 1.5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 3] Abrasive dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 400 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.25
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Saccharin sodium 0.3
Thickening silica 3
Titanium oxide 0.4
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol-type non-abrasive dentifrice composition.
Stock solution 95%
(E) Dimethyl ether 5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 4] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 400 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.25
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Titanium oxide 0.4
Polyoxyethylene (5) stearyl ether 1
Polyoxyethylene (20) hydrogenated castor oil 1
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95%
(E) Dimethyl ether 5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 5] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 300 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.15
Carrageenan 0.1
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Dipotassium glycyrrhizinate 0.1
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Titanium oxide 0.4
Blue No. 1 0.001
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95%
(E) Isopentane 3.5
Carbon dioxide 1.5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Prescription Example 6] Dentifrice composition (A) Sodium cocoylmethyl taurate 1.5%
(B) Polyethylene glycol # 300 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.15
Carrageenan 0.1
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Potassium nitrate 9.3
Sodium tripolyphosphate 1
Dipotassium glycyrrhizinate 0.1
Saccharin sodium 0.2
Sucralose 0.1
Thickening silica 3
Silica 5
Titanium oxide 0.4
Blue No. 1 0.001
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95%
(E) Isopentane 3.5
Carbon dioxide 1.5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 7] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Polyethylene glycol # 300 2.5
Sorbit 20
Glycerin 22
(C) Xanthan gum 0.15
Carrageenan 0.1
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Potassium nitrate 9.3
Sodium tripolyphosphate 1
Dipotassium glycyrrhizinate 0.1
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Titanium oxide 0.4
Blue No. 1 0.001
Quinoline Yellow 0.001
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95
(E) Isopentane 3.5
Carbon dioxide 1.5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

[Formulation Example 8] Dentifrice composition (A) Sodium lauryl sulfate 1.5%
(B) Glycerin 44.5
(C) Xanthan gum 0.15
Carrageenan 0.1
(D) Isopropylmethylphenol 0.05
(F) Palm oil fatty acid amidopropyl betaine 0.1
(G) 3-Octanol 0.005
(H) Anisaldehyde 0.005
Sodium fluoride 0.3
Saccharin sodium 0.3
Thickening silica 3
Silica 5
Titanium oxide 0.4
Blue No. 1 0.001
Quinoline Yellow 0.001
Fragrance composition A 1
Purified water remaining
Total 100.00%
The stock solution having the above composition was filled in an aerosol test bottle, and the component (E) was added at the following ratio to obtain an aerosol dentifrice composition.
Stock solution 95
(E) Dimethyl ether 5
Total 100%
(A) / (D) mass ratio 30
Stock solution: propellant = 95: 5

表中、部はいずれも質量部である（以下、同様。）。

In the table, all parts are parts by mass (the same applies hereinafter).

Claims (6)

(A) an anionic surfactant,
(B) a wetting agent,
An isopropylmethylphenol-containing dentifrice composition containing (C) an organic thickener and (D) isopropylmethylphenol and having a mass ratio of (A) / (D) of 10 to 150 is (E) injection An aerosol dentifrice composition, which is filled in an aerosol container together with an agent.   The aerosol dentifrice composition according to claim 1, wherein (B) the wetting agent is a combination of glycerin, sorbit and polyethylene glycol having an average molecular weight of 190 to 630.   (E) The aerosol dentifrice composition according to claim 1 or 2, wherein the propellant is a liquefied gas.   The aerosol dentifrice composition according to any one of claims 1 to 3, further comprising (F) a betaine-type surfactant.   Furthermore, (G) 1 type, or 2 or more types of fragrance | flavor components chosen from 3-octanol, 3-octyl acetate, 3-octanone, and Fencon are contained, The any one of Claims 1 thru | or 4 characterized by the above-mentioned. Aerosol dentifrice composition.   The aerosol dentifrice composition according to claim 5, further comprising (H) anisaldehyde.