WO2016136796A1

WO2016136796A1 - Aerosol-type intraoral cleaning composition

Info

Publication number: WO2016136796A1
Application number: PCT/JP2016/055403
Authority: WO
Inventors: 沙織滝; 妥治加藤
Original assignee: ライオン株式会社
Priority date: 2015-02-26
Filing date: 2016-02-24
Publication date: 2016-09-01
Also published as: JP2016160179A; CN107405276A; JP6529158B2; KR20170122719A

Abstract

The purpose of the present invention is to provide, as an intraoral cleaning composition for easily cleaning the inside of the oral cavity by being directly sprayed e.g. between the teeth, an aerosol-type intraoral cleaning composition that is reduced in pungent odor, is less harmful to the teeth, the oral mucosa, the gums, etc., and is reduced in sediment precipitation. Disclosed is an aerosol-type intraoral cleaning composition which is a liquid composition for easily cleaning the inside of the oral cavity by being directly sprayed e.g. between the teeth with e.g. an aerosol container, the intraoral cleaning composition comprising the following components. Component (A): cetylpyridinium chloride and/or benzethonium chloride; component (B): an undiluted solution including glycerol and/or propylene glycol; and component (C): a spraying agent including nitrogen and/or nitrous oxide.

Description

Aerosol-type oral cleaning composition

The present invention relates to an aerosol type oral cavity cleaning composition.
This application claims priority based on Japanese Patent Application No. 2015-036959 filed in Japan on February 26, 2015, the contents of which are incorporated herein by reference.

As a method of removing plaque such as between teeth, there is a method of physically removing with an interdental brush or floss. However, a technique is required to insert the interdental brush or floss between the teeth, and if the gingiva is weak, the gingiva may be damaged by the interdental brush or floss.

Therefore, a method has been proposed in which a stock solution containing a bactericidal agent or the like is sprayed from an aerosol container onto teeth, interdental teeth, gums, and the like to remove plaque and the like and easily wash the oral cavity (Patent Document 1). . In this method, an aerosol type oral cavity cleaning composition containing a stock solution and a propellant for jetting the stock solution is used.

Liquefied gas is generally used as a propellant for an aerosol-type intraoral cleaning composition. However, when a liquid composition containing a liquefied gas is directly injected into the oral cavity, there is a problem that a specific irritating odor is produced. In addition, the liquefied gas causes problems such as numbness of the tongue and harmfulness to the oral mucosa.

Specifically, it has been proposed to use carbon dioxide or nitrogen as a propellant (Patent Documents 1 and 2). However, when carbon dioxide is directly injected into the oral cavity, it has an irritating odor, and even if a pH adjuster is blended, the pH of the sprayed liquid composition tends to be lower than 5.5. Moreover, since nitrogen is harmful to teeth, oral mucosa, gingiva, etc., it is difficult to cause harmful problems. However, when nitrogen is directly injected into the oral cavity, although it is milder than carbon dioxide or the like, it has a specific irritating odor and may cause precipitation in the composition.

JP 2002-104554 A Japanese Patent Laid-Open No. 5-345026

The present invention is an aerosol-type oral cleaning composition that is sprayed directly between teeth to easily clean the inside of the oral cavity, which suppresses irritating odors and reduces harmfulness to teeth, oral mucosa, gingiva, etc. An object of the present invention is to provide an aerosol-type intraoral cleaning composition in which the deposition of sediment is suppressed.

The aerosol-type intraoral cleaning composition of the present invention includes a stock solution and a propellant, and the stock solution contains (A) component: one or both of cetylpyridinium chloride and benzethonium chloride, and (B) component: One or both of glycerin and propylene glycol are contained, and the propellant contains (C) component: either one or both of component (N) and nitrogen and nitrous oxide.

The content of the component (A) in the stock solution is preferably 0.001 to 0.1% by mass with respect to the total mass of the stock solution.
The content of the component (B) in the stock solution is preferably 1 to 12% by mass with respect to the total mass of the stock solution.

The aerosol type oral cavity cleaning composition of the present invention is a composition for easily cleaning the oral cavity by spraying directly between the teeth, etc., and the irritating odor is suppressed, causing harm to teeth, oral mucosa, gingiva, etc. Property is reduced, and the precipitation of sediment is suppressed.

The aerosol-type intraoral cleaning composition of the present invention (hereinafter simply referred to as “oral cleaning composition”) includes a stock solution containing the components (A) and (B), a propellant containing the component (C), and The composition containing.

[Undiluted solution]
The stock solution contains the component (A) and the component (B). By containing the component (A) and the component (B) in the stock solution, the irritating odor when the intraoral cleaning composition of the present invention is sprayed into the oral cavity is suppressed, and the precipitation of orientation is suppressed.
The stock solution means all components other than the propellant contained in the oral cleaning composition of the present invention.

((A) component)
The component (A) is one or both of cetylpyridinium chloride and benzethonium chloride (also referred to as benzethonium chloride). That is, the stock solution may contain only one of cetylpyridinium chloride or benzethonium chloride as the component (A), or may contain both cetylpyridinium chloride and benzethonium chloride.

The content of component (A) in the stock solution is preferably 0.001 to 0.1% by mass, more preferably 0.005 to 0.05% by mass, based on the total mass of the stock solution. If content of (A) component is more than the said lower limit, when an intraoral cleaning composition is injected in an intraoral area, an irritating odor will become harder to feel and it is easy to suppress sedimentation. If content of (A) component is below the said upper limit, the irritation | stimulation derived from (A) component will become hard to feel, and precipitation of an orientation will be easy to be suppressed.

((B) component)
The component (B) is one or both of glycerin and propylene glycol. That is, the stock solution may contain only one of glycerin and propylene glycol as the component (B), or may contain both glycerin and propylene glycol.

The content of component (B) in the stock solution is preferably 1 to 12% by weight, more preferably 2 to 10% by weight, based on the total weight of the stock solution. If content of (B) component is more than the said lower limit, when an intraoral cleaning composition is injected in an intraoral area, an irritating odor will become harder to feel and it is easy to suppress sedimentation. If content of (B) component is below the said upper limit, the irritation | stimulation derived from (B) component will become more difficult to feel, and corrosion inside a container will also become difficult to occur.

(solvent)
The stock solution preferably contains water as a solvent. As water, purified water is preferred. As the solvent, ethanol or the like may be used. As the solvent, a mixture of water and ethanol may be used.

The content of the solvent in the stock solution (100% by mass) is preferably 50 to 99% by mass, and more preferably 80 to 99% by mass. When a mixture of water and ethanol is used, the ratio of the mass of ethanol to the total mass of water and ethanol is preferably 0 to 30% by mass. In addition, the total content of (A) component, (B) component, and a solvent does not exceed 100 mass%.

(Optional component)
The stock solution may contain an optional component other than the component (A), the component (B), and the solvent in addition to the component (A) and the component (B) as necessary. As an arbitrary component, what is normally used for the composition for intraoral cleaning can be used, For example, the component shown below is mentioned.

Bactericides such as chlorohexidine, triclosan, isopropylmethylphenol, zinc gluconate, zinc citrate (excluding cetylpyridinium chloride and benzethonium chloride).
Anti-inflammatory agents such as tranexamic acid, glycyrrhizic acid dipotassium salt, ε-aminocaproic acid, and buckwheat extract.
Calculus preventives such as condensed phosphates and ethane hydroxydiphosphonates.

Astringents such as allantoin chlorohydroxyaluminum, vitamin C, lysozyme chloride, glycyrrhetinic acid and its salts, sodium chloride and allantoin.
Hypersensitivity inhibitors such as potassium nitrate.
Dental enhancers such as sodium fluoride, hexafluorosilicic acid and salts thereof.
Stain removers such as sodium polyphosphate and sodium metaphosphate.

Local stimulants such as l-menthol, dl-menthol, mint oil.
Local anesthetics such as dibucaine hydrochloride and ethyl aminobenzoate.
Tissue repair agents such as copper chlorophyllin sodium.
Bad breath prevention agents such as parsley seed oil, green tea extract, furanovoid, chlorophyll, champignon extract.

Anionic surfactants such as alkyl sulfates (sodium lauryl sulfate, sodium myristyl sulfate, etc.) and sodium α-olefin sulfonate.
Nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, glycerin fatty acid ester and the like.
Amphoteric surfactants such as alkylbetaine surfactants, amine oxide surfactants, imidazolinium betaine surfactants.

Sweetening agents such as saccharin sodium, stevioside, stevia extract, glycyrrhizin, sucrose, glucose, dextrose, invert sugar, fructose, oligosaccharide, reduced starch syrup, and aspartame.
Preservatives such as sodium benzoate, p-hydroxybenzoate (methylparaben, ethylparaben, butylparaben, etc.), ethylenediaminetetraacetate, benzalkonium chloride.
Vitamins such as ascorbic acid and its derivatives, tocopherol and its derivatives, riboflavin, pyridoxine hydrochloride, cyanocobalamin, β-carotene, ergocalciferol, menadione and ubiquinone.

Natural flavors (eucalyptus oil, thyme oil, sage oil, basil oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, etc.), single flavor (limonene, pinene, butanol, methyl salicylate, ethyl salicylate, methylcinnamate, methyl) Fragrances such as anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol, etc.), blended fragrance (strawberry flavor, apple flavor, melon flavor, etc.), fragrance solvent (ethyl alcohol, triacetin, glycerin fatty acid ester, etc.).
As the optional component, one type may be used alone, or two or more types may be used in combination.

The method for preparing the stock solution is not particularly limited, and for example, the stock solution can be prepared by adding (A) component and (B) component to a solvent such as purified water and optional components to be used as needed and stirring. .

[Propellant]
A propellant is a component for injecting a stock solution, and is filled in a container as a compressed gas or a liquefied gas together with the stock solution. Note that the compressed gas means a gas that is compressed to a level that does not liquefy at a normal temperature and that has a pressure equal to or higher than atmospheric pressure. The liquefied gas means a gas that is actually a liquid and has a boiling point of 40 ° C. or lower under atmospheric pressure or a liquid having a boiling point higher than 40 ° C. under atmospheric pressure.

The pressure in the container in a state where the container is filled with the propellant together with the stock solution is preferably 0.2 to 1.0 MPa, and more preferably 0.5 to 1.0 MPa.
A propellant contains (C) component.

((C) component)
The component (C) is one or both of nitrogen and nitrous oxide. That is, the propellant may contain only one of nitrogen and nitrous oxide as the component (C), or may contain both nitrogen and nitrous oxide.

In the oral cavity cleaning composition of the present invention, the volume ratio of the stock solution to the propellant in the container (stock solution / propellant) is preferably 80/20 to 40/60, more preferably 70/30 to 50/50. For example, when the stock solution and the propellant are filled so that the pressure in the container is 0.72 MPa, the volume ratio of the stock solution and the propellant (stock solution / propellant) in the container is preferably within the above range. The more the propellant, the better the jetability. The more undiluted solution, the more easily the masking effect by the component (A) and the component (B) is exhibited, and the irritating odor is easily suppressed.

[PH]
The pH at 25 ° C. of the oral cleaning composition of the present invention is preferably 5.5 to 8.0, more preferably 5.8 to 7.0. If pH is more than the said lower limit, it will be easy to reduce harmfulness to a tooth | gear, an oral mucosa, etc. If pH is below the said upper limit, since it is easy to reduce a harmfulness to an oral mucosa, the masking effect by (A) component and (B) component is easy to be exhibited, and an irritating odor is easy to be suppressed.

[how to use]
Examples of the method for using the oral cleaning composition of the present invention include a method using an aerosol container that can spray the oral cleaning composition between teeth.
The aerosol container is not particularly limited as long as the oral cleaning composition can be sprayed between the teeth and the like, for example, a container body filled with the oral cleaning composition, and attached to the upper part of the container body A thing provided with an injection part is mentioned.

The container body is not particularly limited, and for example, a known pressure resistant container can be used.
As the injection unit, for example, a mechanism that includes an injection nozzle mounted on the upper part of the container body and a push button, and when the push button is depressed, a mechanism for injecting the oral cleaning composition in the container body through the injection nozzle The thing which has is mentioned. As a mechanism for injecting the oral cleaning composition, a known mechanism that is usually used for aerosol containers can be employed.

Examples of the injection nozzle include those having a nozzle body portion extending upward from the upper portion of the container body and having a tip portion bent forward, and a nozzle tip portion protruding from the tip surface of the nozzle body portion. . In the spray nozzle, the oral cavity cleaning composition can be sprayed stably between the teeth by applying the nozzle tip to the recess between the teeth.

In the above-described aerosol container, the container body is filled with the stock solution and the propellant, the tip of the nozzle is applied to the dent between the teeth, and the push button is pressed down, so that the oral cleaning composition is passed through the injection nozzle. It is sprayed in between, and plaque etc. are removed. A method for filling the container body with the stock solution and the propellant is not particularly limited, and a known method can be adopted.

Thus, the intraoral cleaning composition of the present invention can be used in a method for removing plaque between teeth. That is, the interdental plaque removal method is a method for removing plaque by spraying the oral cleaning composition of the present invention filled in the container body of the aerosol container from the spray nozzle toward the teeth. . The injection amount of the oral cleaning composition can be appropriately set.

In the oral cavity cleaning composition of the present invention described above, it is possible to easily remove the dirt and plaque between teeth by directly spraying between the teeth without brushing with an abrasive. Can be washed.
Moreover, in the intraoral cleaning composition of this invention, since (C) component is used for a propellant, the harmfulness to teeth, oral mucosa, gingiva etc. is reduced. Moreover, by combining the propellant containing the component (C) and the stock solution containing the component (A) and the component (B), the irritating odor due to the propellant is suppressed, and the precipitation of sediment is suppressed. .

EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited by the following description.
[material]
The raw materials used in this example are shown below.

((A) component)
A-1: Cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.).
A-2: Benzethonium chloride (Lonza Japan Co., Ltd.).

((B) component)
B-1: Glycerin (manufactured by Sakamoto Pharmaceutical Co., Ltd.).
B-2: Propylene glycol (manufactured by Asahi Glass Co., Ltd.).

(Optional component)
Citric acid (manufactured by Komatsuya Co., Ltd.).
Na citrate: sodium citrate (manufactured by Komatsuya Co., Ltd.).
EtOH: Ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.).
Fragrances A to F: Fragrances shown in Tables 1 to 7. “Parts” in Tables 2 to 7 mean parts by mass.

(solvent)
purified water.

((C) component)
C-1: Nitrogen (0.72 MPa, manufactured by Joto Nikko Corporation).
C-2: Nitrous oxide (0.72 MPa, manufactured by Toshokai Co., Ltd.).

((C ′) component: comparative component)
C′-1: carbon dioxide (0.72 MPa, experimental gas “carbon dioxide”, manufactured by Nakamura Science Co., Ltd.).
C′-2: Liquefied gas (0.72 MPa, dimethyl ether (DME), manufactured by Osaka Liquefied Gas Co., Ltd.).

[Examples 1 to 17, Comparative Examples 1 to 4]
Components (A), (B) and optional components (other than purified water) were sequentially added to purified water in the proportions shown in Tables 8 and 9, and stirred to dissolve uniformly to prepare a stock solution. A three-one motor (BL1200, manufactured by HEIDON) was used for preparing the stock solution.
Then, the stock solution and the propellant were filled in a pressure-resistant container so that the volume ratio of the stock solution and the propellant (stock solution / propellant) was the ratio shown in Table 8 and Table 9, and an oral cleaning composition was prepared. .

[Irritating odor evaluation]
Using an aerosol container, the irritating odor felt when the oral cleaning composition immediately after preparation was sprayed between teeth was determined according to the following criteria. Judgment was performed by 10 healthy subjects, and an irritating odor was evaluated based on the following criteria from the average value thereof.
(Criteria)
4: No pungent odor at all.
3: There is very little irritating odor.
2: There is a slight pungent odor.
1: There is a considerable pungent odor.
(Evaluation criteria)
A: The average value is 3.5 points or more.
A: The average value is 3.0 points or more and less than 3.5 points.
Δ: The average value is 2.0 points or more and less than 3.0 points.
X: The average value is less than 2.0 points.

[External evaluation for gingiva]
Using the aerosol container, the irritation feeling felt in the gums when the intraoral cleaning composition immediately after preparation was sprayed between the teeth was determined according to the following criteria. Judgment was made by 10 subjects with sensitive oral mucosa, and the externality was evaluated from the average value to gingiva according to the following criteria.
(Criteria)
4: There is no irritation.
3: There is very little irritation.
2: There is a slight irritation.
1: There is considerable irritation.
(Criteria)
A: The average value is 3.5 points or more.
A: The average value is 3.0 points or more and less than 3.5 points.
Δ: The average value is 2.0 points or more and less than 3.0 points.
X: The average value is less than 2.0 points.

[Ori precipitation evaluation]
The oral cleansing composition immediately after preparation is filled in 80 mL of a transparent PET container with a full injection amount of 80 mL, stored at 5 ° C. for 1 month, returned to room temperature, and then gently displaced according to the following criteria. Visually evaluated.
(Evaluation criteria)
A: There is no orientation.
○: There is very little orientation.
Δ: There is some orientation.
X: There is considerable orientation.

Tables 8 and 9 show the compositions of the oral cavity cleaning compositions of Examples and Comparative Examples, and the evaluation results.
In addition, the “balance” of the content of purified water in Tables 8 and 9 is an amount required to make 100% by mass of the whole stock solution. The column of propellant indicates the ratio (volume%) of the component (C) or the component (C′-1) in the propellant.

As shown in Tables 8 and 9, the mouthwash compositions of Examples 1 to 17 containing the stock solution containing the components (A) and (B) and the propellant containing the component (C) Was suppressed, and the harmfulness to gingiva was reduced.
In the oral cavity cleaning compositions of Comparative Examples 1 and 2 that did not contain either the component (A) or the component (B), the deposition of irritating odors and orientations was not sufficiently suppressed.
In the oral cavity cleaning composition of Comparative Example 3 using carbon dioxide instead of the component (C) as a propellant, the irritating odor was not sufficiently suppressed.
In the oral cavity cleaning composition of Comparative Example 4 using liquefied gas (DME) instead of the component (C) as a propellant, the irritating odor was not sufficiently suppressed, and the harmfulness to gingiva was not sufficiently reduced. .

Claims

Including undiluted solution and propellant,
The stock solution contains (A) component: either or both of cetylpyridinium chloride and benzethonium chloride, and (B) component: either or both of glycerin and propylene glycol,
The propellant is an aerosol type oral cavity cleaning composition containing (C) component: any one or both of nitrogen and nitrous oxide.
The aerosol-type intraoral cleaning composition according to claim 1, wherein the content of the component (A) in the stock solution is 0.001 to 0.1% by mass.
The aerosol type oral cavity cleaning composition according to claim 1 or 2, wherein the content of the component (B) in the stock solution is 1 to 12% by mass.