KR20170122719A - Aerosol-type oral cleaning composition - Google Patents

Abstract

The present invention relates to an oral cavity cleansing composition for easily cleansing the inside of a mouth by spraying directly to teeth or the like. The composition of the present invention is an aerosol-type oral cleansing composition with reduced irritation, reduced risk to teeth, oral mucous membranes, gums and the like, And to provide the above objects. (A): either or both of cetylpyridinium chloride and benzethonium chloride, and (B) a component: glycerin and propylene glycol (C). The liquid composition according to claim 1, (C): an injecting agent containing either or both of nitrogen and nitrous oxide, and an aerosol type oral cleaning composition comprising the same.

Description

Aerosol-type oral cleaning composition

The present invention relates to an intraoral cleansing composition of the aerosol type.

The present application claims priority based on Japanese Patent Application No. 2015-036959 filed on Feb. 26, 2015, the contents of which are incorporated herein by reference.

As a method of removing plaque such as interdental space, there is a method of physically removing the plaque by an interdental brush and a floss (floss). However, techniques for inserting the interdental brush or floss into the interdental space are necessary, and when the gum is weak, the interdental brush or the floss may damage the gum.

Thus, a method has been proposed in which a plaque or the like is removed by jetting a stock solution containing a bactericide or the like from an aerosol container to teeth, interdental spaces, teeth, etc. to easily clean the oral cavity (Patent Document 1). In that method, an aerosol-type oral cleaning composition is used which includes a stocking agent and a jetting agent for jetting the stocking solution.

A liquefied gas is generally used as a jetting agent for an aerosol-type oral cleaning composition. However, when the liquid composition containing the liquefied gas is injected directly into the oral cavity, there is a problem that a specific irritation occurs. In addition, the liquefied gas is also a problem with the oral mucosa, such as tingling the tongue.

Specifically, it has been proposed to use carbon dioxide or nitrogen as a jetting agent (Patent Documents 1 and 2). However, when carbon dioxide is injected directly into the oral cavity, irritation occurs and the pH of the sprayed liquid composition tends to fall below 5.5 even when the pH adjusting agent is blended. In addition, nitrogen is unlikely to present a risk problem for teeth, oral mucosa, gums, and the like. However, when nitrogen is injected directly into the oral cavity, it is alleviated as compared with carbon dioxide and the like, but there is a specific irritation and precipitation may occur in the composition.

Patent Document 1: JP-A-2002-104554 Patent Document 2: JP-A-5-345026

The present invention relates to an aerosol-type oral cleaning composition for easily cleansing an oral cavity by spraying directly into teeth or the like. The present invention provides a composition for oral cavity which is capable of suppressing irritation and reducing the risk to teeth, oral mucosa, gums and the like, It is an object of the present invention to provide an oral cavity type oral cleaning composition.

The aerosol-type oral cleansing composition of the present invention comprises a stock solution and a jetting agent, wherein the stock solution contains (A) component: either or both of cetylpyridinium chloride and benzethonium chloride, and (B) And propylene glycol, and the injecting agent comprises either or both of the components (C): nitrogen and nitrous oxide.

The content of the component (A) in the stock solution is preferably 0.001 to 0.1 mass% with respect to the total mass of the stock solution.

The content of the component (B) in the stock solution is preferably 1 to 12 mass% with respect to the total mass of the stock solution.

The aerosol-type oral cleansing composition of the present invention is a composition for easily cleansing the oral cavity by spraying directly into the teeth or the like. The composition of the present invention suppresses irritation, reduces the risk to teeth, oral mucosa, gums and the like, Is suppressed.

The aerosol-type oral cleaning composition of the present invention (hereinafter referred to simply as " oral cleaning composition ") comprises a stock solution containing components (A) and (B) ≪ / RTI >

[Undiluted solution]

The undiluted solution includes the component (A) and the component (B). By containing the component (A) and the component (B) in the undiluted solution, the irritation at the time of spraying the oral cleaning composition of the present invention into the oral cavity is suppressed, and precipitation of the precipitate is suppressed.

The undiluted solution means all components other than the injection agent contained in the oral cleaning composition of the present invention.

(Component (A))

The component (A) is either or both of cetylpyridinium chloride and benzethonium chloride (also referred to as benzethonium chloride). That is, the undiluted solution may contain either one of cetylpyridinium chloride or benzethonium chloride as the component (A), and may contain both cetylpyridinium chloride and benzethonium chloride.

The content of the component (A) in the stock solution is preferably 0.001 to 0.1 mass%, more preferably 0.005 to 0.05 mass%, based on the total mass of the stock solution. When the content of the component (A) is not less than the lower limit, the irritating odor is less likely to be felt when the intraoral cleaning composition is injected into the mouth, and precipitation of the precipitate is liable to be suppressed. If the content of the component (A) is less than the upper limit value, the stimulus derived from the component (A) is less likely to be felt and precipitation of the precipitate is likely to be suppressed.

(Component (B)).

The component (B) is either or both of glycerin and propylene glycol. That is, the undiluted solution may contain either one of glycerin or propylene glycol as the component (B), and may contain both glycerin and propylene glycol.

The content of the component (B) in the stock solution is preferably 1 to 12 mass%, more preferably 2 to 10 mass%, based on the total mass of the stock solution. When the content of the component (B) is not less than the lower limit value, the irritating odor is less likely to be felt when the intraoral cleaning composition is injected into the mouth, and precipitation of the precipitate is liable to be suppressed. If the content of the component (B) is less than the upper limit, the stimulus derived from the component (B) becomes less likely to be felt, and the inside of the container is less likely to be corroded.

(menstruum)

It is preferable that the undiluted solution contains water as a solvent. As the water, purified water is preferable. As the solvent, ethanol or the like may be used. As the solvent, a mixture of water and ethanol may be used.

The content of the solvent in the undiluted solution (100 mass%) is preferably 50 to 99 mass%, more preferably 80 to 99 mass%. When a mixture of water and ethanol is used, the ratio of the mass of ethanol to the total mass of water and ethanol is preferably 0 to 30 mass%. The total content of the component (A), the component (B) and the solvent is not more than 100% by mass.

(Optional component)

The raw liquid may contain, in addition to the component (A) and the component (B), an optional component other than the component (A), the component (B) and the solvent, if necessary. As the optional ingredient, those generally used for the composition for oral cavity cleansing can be used, and for example, the following ingredients can be mentioned.

Fungicides such as chlorohexidine, triclosan, isopropylmethylphenol, zinc gluconate and zinc citrate, except cetylpyridinium chloride and benzethonium chloride.

Antiinflammatory agents such as tranexamic acid, dipotassium glycyrrhizinate,? -Aminocaproic acid, and yellowish white extract.

An anti-tartar agent such as a condensed phosphate or ethane hydroxydiphosphonate.

Allantoin chlorhydroxy aluminum, vitamin C, lysozyme chloride, glycyrrhetinic acid and its salts, sodium chloride and allantoin.

Sensitizer inhibitors such as potassium nitrate.

Sodium hypophosphite, sodium fluoride, hexafluorosilicic acid and salts thereof.

Stain remover such as sodium polyphosphate, sodium metaphosphate and the like.

Local stimulants such as l-menthol, dl-menthol, and peppermint oil.

Local anesthetics such as dibucaine hydrochloride and ethyl amino benzoate.

Copying of tissue number such as copper chlorophyllin sodium.

Poultice seed oil, green tea extract, flavonoid, chlorophyll, and chewphinion extract.

Anionic surfactants such as alkylsulfates (sodium laurylsulfate, sodium myristylsulfate and the like) and sodium alpha-olefinsulfonate.

Nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, and glycerin fatty acid esters.

Amphoteric surfactants such as alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants.

Sweetener such as sodium saccharin, stevioside, stevia extract, glycyrrhizin, sucrose, glucose, dextrose, phosgene, fructose, oligosaccharide, water syrup, aspartame.

Preservatives such as sodium benzoate, p-oxybenzoic acid ester (methylparaben, ethylparaben, butylparaben, etc.), ethylenediaminetetraacetate, benzalkonium chloride.

Vitamins such as ascorbic acid and its derivatives, tocopherol and its derivatives, riboflavin, pyridoxine hydrochloride, cyanocobalamin,? -Carotene, ergocalciferol, menadione and ubiquinone.

Natural fragrances (such as eucalyptus, time oil, sage oil, basil oil, iris concrete, rose abscess, orange flower absolute, vanilla extract, etc.), single product flavoring (limonene, pinene, butanol, methyl salicylate, salicylic acid (Ethyl alcohol, triacetin, methylcyclohexanone, ethylcyclohexanone, methylcycinnamate, methyl anthranilate, phenyl ethyl glycidate, ethyl lactate, vanillin and maltol) Glycerin fatty acid esters, etc.).

The optional components may be used alone, or two or more of them may be used in combination.

The method for preparing the undiluted solution is not particularly limited, and for example, the undiluted solution can be prepared by adding the component (A) and the component (B) to a solvent such as purified water and adding optional components to be used as needed.

[Injection agent]

The injecting agent is a component for injecting the undiluted solution and is filled in the vessel as a compressed gas or a liquefied gas together with the undiluted solution. Further, the compressed gas means a gas which is compressed to such an extent that it is not liquefied at a normal temperature, and the pressure is atmospheric pressure or higher. Liquefied gas means a gas which is actually liquid, has a boiling point of 40 ° C or lower under atmospheric pressure, or a gas whose boiling point exceeds 40 ° C at atmospheric pressure, at a boiling point or higher.

The pressure in the vessel in the state in which the jetting agent is filled with the undiluted solution in the vessel is preferably 0.2 to 1.0 MPa, more preferably 0.5 to 1.0 MPa.

The injecting agent comprises component (C).

(Component (C)) [

The component (C) is either or both of nitrogen and nitrous oxide. That is, the injecting agent may contain either of nitrogen and nitrous oxide as the component (C), or may contain both nitrogen and nitrous oxide.

With respect to the oral cleaning composition of the present invention, the volume ratio of the undiluted solution and the injecting agent in the container is preferably 80/20 to 40/60, more preferably 70/30 to 50/50 . For example, when the raw liquid and the jetting agent are charged so that the pressure in the vessel is 0.72 MPa, the volume ratio of the undiluted liquid and the jetting agent in the vessel (raw liquid / jetting agent) is preferably within the above range. The more injected, the better the sprayability. The more the undiluted solution is, the more easily the masking effect by the component (A) and the component (B) tends to be exhibited, and the irritating odor is liable to be suppressed.

[pH]

The pH of the oral cleaning composition of the present invention at 25 캜 is preferably 5.5 to 8.0, more preferably 5.8 to 7.0. If the pH is lower than the lower limit described above, the risk to the teeth, the oral mucous membranes and the like is easily reduced. If the pH is below the upper limit, the risk to the oral mucous membrane is easily reduced, and the masking effect by the component (A) and the component (B) tends to be exerted, and the irritation is liable to be suppressed.

[How to use]

As a method of using the oral cleaning composition of the present invention, there is a method of using an aerosol container capable of spraying the intraoral cleaning composition into the interdental area.

The aerosol container is not particularly limited as long as it is capable of jetting the intraoral cleaning composition into the interdental space. For example, the aerosol container may include a container main body filled with a cleaning composition for oral cavity and a spray portion mounted on the top of the container main body .

The container body is not particularly limited, and for example, a known pressure-resistant container can be used.

Examples of the jetting section include a jetting nozzle mounted on the upper part of the container body and a mechanism having a push button and jetting the intraoral cleaning composition in the container body through the jetting nozzle when the push button is pressed . The mechanism for spraying the oral cleaning composition may be a known mechanism commonly used in aerosol containers.

The injection nozzle may include, for example, a nozzle body portion extending upward from an upper portion of the container main body and having a tip portion bent forward, and a nozzle tip portion protruding from a tip end surface of the nozzle body portion. In the injection nozzle, the oral cavity cleaning composition can be stably sprayed between the teeth by touching the tip of the nozzle at a recessed position between the teeth.

In the aerosol container described above, the oral liquid and injecting agent are filled in the container body, and the tip of the nozzle is put on a recessed place between the teeth so that the push-button is pressed down so that the oral cleaning composition is sprayed to the interdental space through the spray nozzle, Is removed. The method of filling the stock solution and the injecting agent in the container body is not particularly limited and a known method can be employed.

As described above, the oral cleaning composition of the present invention can be used for a method of removing plaque from the teeth. That is, a method of removing plaque between teeth is a method of spraying the oral cleaning composition of the present invention filled in the container body of the aerosol container from the spray nozzle toward the teeth, thereby removing the plaque. The injection amount of the oral cleaning composition can be appropriately set.

In the oral cleaning composition of the present invention described above, the inside of the oral cavity can be easily cleaned by removing dirt and plaque from the teeth by spraying directly to teeth or the like without brushing using an abrasive.

Further, in the oral cleaning composition of the present invention, since the component (C) is used as the injecting agent, the risk to teeth, oral mucosa, gums and the like is reduced. Further, by combining the jet agent containing the component (C) with the stock solution containing the component (A) and the component (B), the irritation caused by the jetting agent is suppressed and precipitation of the precipitate is suppressed.

Hereinafter, the present invention will be described in detail by way of examples, but the present invention is not limited by the following description.

[Raw material]

The raw materials used in this embodiment are shown below.

(Component (A))

A-1: Cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.).

A-2: Benzethonium chloride (manufactured by Lone Japan Co., Ltd.).

(Component (B)).

B-1: Glycerin (manufactured by Sakamoto Pharmaceutical Industry Co., Ltd.).

B-2: Propylene glycol (manufactured by Asahi Kasei Corporation).

(Optional component)

Citric acid (manufactured by Komatsuya Kogyo Co., Ltd.).

Citric acid Na: Sodium citrate (manufactured by Komatsuya Kogyo Co., Ltd.).

EtOH: ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.).

Flavors A to F: Flavors shown in Tables 1 to 7. &Quot; Parts " in Tables 2 to 7 means mass parts.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

[Table 7]

(menstruum)

Purified water.

(Component (C)) [

C-1: Nitrogen (0.72 MPa, manufactured by Japan Epoxy Resin Co., Ltd.).

C-2: nitrous oxide (0.72 MPa, manufactured by Watari Sangyo Co., Ltd.).

((C ') component: comparative component)

C'-1: Carbon dioxide (0.72 MPa, experimental gas " carbon dioxide ", manufactured by Nakamura Chemical Industry Co., Ltd.).

C'-2: Liquefied gas (0.72 MPa, dimethyl ether (DME), manufactured by Osaka Gas Co., Ltd.).

[Examples 1 to 17, Comparative Examples 1 to 4]

The components (A), (B), and optional components (other than purified water) were sequentially added to the purified water in the ratios shown in Tables 8 and 9, stirred and uniformly dissolved to prepare a stock solution. A Sri One motor (BL1200, manufactured by HEIDON) was used for the preparation of the stock solution.

Subsequently, the pressurized container was filled with the undiluted solution and the injecting agent so that the volume ratio of the undiluted solution and the injecting agent (undiluted solution / injecting agent) was as shown in Tables 8 and 9, thereby preparing an oral cavity cleaning composition.

[Evaluation of irritation]

Using an aerosol container, the irritation felt when the intraoral cleaning composition immediately after preparation was sprayed to the teeth was judged according to the following criteria. The judgment was made by 10 healthy subjects, and an evaluation of the irritation was made based on the following criteria from their average values.

(Criteria)

4: There is no irritation at all.

3: There is very slight irritation.

2: There is a slight irritation.

1: There is considerable irritation.

(Evaluation standard)

A: Average value is 3.5 or more.

?: Average value is 3.0 or more and less than 3.5 points.

?: Average value is 2.0 or more and less than 3.0 points.

X: Average value is less than 2.0.

[Risk Assessment to Gums]

Using an aerosol container, the sensation of irritation felt in the gums when the oral cleaning composition immediately after preparation was sprayed into the teeth was judged according to the following criteria. The judgment was made by ten subjects with irritable oral mucosa, and the risk to the gums was evaluated from their average value according to the following criteria.

(Criteria)

4: There is no stimulation at all.

3: The stimulus is extremely slight.

2: There is a slight stimulation.

1: There is considerable stimulation.

(Criteria)

A: Average value is 3.5 or more.

?: Average value is 3.0 or more and less than 3.5 points.

?: Average value is 2.0 or more and less than 3.0 points.

X: Average value is less than 2.0.

[Evaluation of precipitate precipitation]

80 ml of the oral cleaning composition immediately after the preparation was filled into a transparent PET container of 80 ml in a mortar, and stored for 1 month under the condition of 5 캜, then returned to room temperature, and about the sediment at the time of gentle displacement , And evaluated visually according to the following criteria.

(Evaluation standard)

◎: There is no sediment.

○: The sediment is extremely small.

△: There is a little sediment.

X: There is considerable sediment.

The composition and the evaluation results of the oral cleaning compositions of Examples and Comparative Examples are shown in Tables 8 and 9.

The " balance " of the content of purified water in Tables 8 and 9 is an amount required to make 100% by mass of the whole stock solution. The column of the jetting agent shows the ratio (volume%) of the component (C) or the component (C'-1) in the jetting agent.

[Table 8]

[Table 9]

As shown in Tables 8 and 9, in the oral cleaning compositions of Examples 1 to 17 comprising the stock solution containing the ingredient (A) and the ingredient (B) and the ingredient (C) When the irritation was suppressed and the risk to the gums was reduced, precipitation of the precipitate was also suppressed.

In the oral cleaning compositions of Comparative Examples 1 and 2 which did not contain either the component (A) or the component (B), the precipitation of the irritating odor and the precipitate was not sufficiently inhibited.

In the oral cleaning composition of Comparative Example 3 using carbon dioxide instead of the component (C) as a jetting agent, the irritating odor was not sufficiently suppressed.

In the oral cleaning composition of Comparative Example 4 using liquefied gas (DME) instead of the component (C) as the propellant, the irritating odor was not sufficiently suppressed and the risk to the gums was not sufficiently reduced.

Claims (3)

Comprising a stock solution and an injecting agent,
Wherein the stock solution comprises at least one of the components (A): cetylpyridinium chloride and benzethonium chloride, and (B) component: either or both of glycerin and propylene glycol,
The aerosol-type oral cleaning composition according to any one of claims 1 to 3, wherein the jetting agent comprises one or both of component (C): nitrogen and nitrous oxide. The method according to claim 1,
Wherein the content of the component (A) in the stock solution is 0.001 to 0.1 mass%. 3. The method according to claim 1 or 2,
Wherein the content of the component (B) in the stock solution is 1 to 12 mass%.