KR101898448B1 - Liquid or liquefied oral composition and agent for inhibiting adherence of tongue plaque - Google Patents

Abstract

A liquid or liquid oral composition and a sulcite adhesion inhibitor which exhibit a high sulcite adhesion inhibiting effect and have a good taste and a low irritation to the oral mucosa and a good feeling of use are provided.
The present invention is characterized by containing (A) a glycerin fatty acid ester having 8 to 14 carbon atoms in the fatty acid and (B) a polyglutarate, and the component (B) / the component (A) (A) and the component (B) is in the range of 0.1 to 150 in terms of a mass ratio. The composition for oral use according to claim 1, .

Description

TECHNICAL FIELD [0001] The present invention relates to a liquid or liquid oral composition and a composition for inhibiting adhesion of an adhesive. BACKGROUND OF THE INVENTION 1. Field of the Invention < RTI ID = 0.0 >

TECHNICAL FIELD The present invention relates to a liquid or liquid oral composition and a sulphate adhesion inhibitor having a high sulphide adhesion inhibiting effect.

Conventionally, a technique using actinidin (protease) has been proposed in Patent Document 1 (International Publication No. 2003/090704 pamphlet) as a technique for eliminating a suture in the oral cavity or inhibiting adhesion of a suture. However, this technique sometimes damaged the oral mucosa.

Further, although a physical cleaning technique using a tongue cleaner is proposed in Patent Document 2 (Japanese Patent Laid-Open No. 2001-161720), in this case, the cleaning property in the tongue is insufficient, and depending on the brushing method, There was a case of giving. Patent Document 3 (Japanese Patent Laid-Open No. 10-182387) discloses a technique for removing a tongue with condensed phosphate, but it is difficult to say that the taste / mouth mucous membrane irritation is sufficient.

Accordingly, there is a demand for a composition for oral use which exhibits a high sensation adherence inhibiting effect and a good feeling of use.

On the other hand, saliva is an important factor in the cleansing of the mouth, but reduction of saliva secretion by dry mouth such as dry mouse affects attachment of the saliva and accelerates adhesion of the saliva. Patent Document 4 (International Publication No. 2005/049050 pamphlet) discloses that polyglutamate is effective as a saliva secretion promoting component. Japanese Patent Application Laid-Open No. 2009-274967 proposes that an oral spray composition prepared by using glycerin together with an organic acid such as citric acid or its salt and a polyglutarate salt is effective for improving the dry feeling of the mouth.

International Publication No. 2003/090704 pamphlet Japanese Patent Application Laid-Open No. 2001-161720 Japanese Unexamined Patent Application Publication No. 10-182387 International Publication No. 2005/049050 pamphlet Japanese Patent Application Laid-Open No. 2009-274967

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a liquid or liquid oral composition and a sulcite adhesion inhibitor which exhibit a high sulcite adhesion inhibiting effect and have a good feeling of use.

(A) a glycerin fatty acid ester having 8 to 14 carbon atoms in fatty acid and (B) a polyglutarate as component (B) in a mass ratio of 0.1 To 150. A liquid or liquid preparation exhibiting excellent sulcite adhesion inhibiting effect can be obtained by combining these ingredients in a range of from 1 to 150. The inventors of the present invention have found that such a preparation has a good taste and a low irritation to the oral mucosa, .

In other words, the present inventors have surprisingly found that the specific glycerin fatty acid ester of the component (A) exhibits an anti-sulcite adhesion effect, and when the component (A) is combined with the polyglutamate of the component (B) (A), the taste is reduced and the irritation is relieved, and the taste is good, the irritation to the oral mucosa is good and the feeling of use is good, and it is preferably applied to the surface of the tongue I found what I could. It is also known that polyglutamate has a saliva secretion promoting effect. However, by using polyglutamate in combination with a specific glycerin fatty acid ester, for example, by spraying or dropping into the oral cavity or by mouthing the oral cavity, It is a new knowledge of the inventors of the present invention.

Accordingly, the present invention provides the following.

[One]

(A) a glycerin fatty acid ester having 8 to 14 carbon atoms in the fatty acid and (B) a polyglutarate, and the component (B) / the component (A) Or a liquid.

[2]

(A) a glycerin fatty acid ester having 8 to 14 carbon atoms in the fatty acid and (B) a polyglutarate, and the component (B) / the component (A) .

(Effects of the Invention)

According to the present invention, it is possible to provide a liquid or liquid oral composition and a sulcitabine adhesion inhibitor which exhibit a high anti-adherence effect and have a good taste and a low irritation to the oral mucosa and a good feeling of use.

Hereinafter, the present invention will be described in more detail. The present invention is characterized in that (A) a glycerin fatty acid ester having 8 to 14 carbon atoms in fatty acid and (B) a polyglutarate salt are used in combination with the component (A) and the component (B) in appropriate proportions.

(A) is a glycerin fatty acid ester having 8 to 14 carbon atoms, preferably 8 to 11 carbon atoms. Those having less than 8 carbon atoms are difficult to obtain, and those having more than 14 carbon atoms have insufficient adhesion inhibiting effect.

Examples of such glycerin fatty acid esters include caprylic acid glyceryl, capric acid glyceryl, undecylenic acid glyceryl, and lauric acid glyceryl. Particularly, glyceryl caprylate, caprylic acid glyceryl, undecylenic acid glycerol The reel is more preferable from the standpoint of the effect of suppressing the adhesion of the glaze.

The amount of the glycerin fatty acid ester of the component (A) is preferably 0.01 to 2% (mass%, hereinafter the same), particularly 0.1 to 1% of the total composition from the viewpoint of the effect of keeping the mouth clean . If the amount is less than 0.01%, the effect of inhibiting adhesion of the adhesive may not be sufficiently exhibited. If the content exceeds 2%, an unpleasant taste may remain after use, and the oral mucous membrane stimulation may become strong.

As the polyglutamic acid salt of component (B), sodium salt or potassium salt of polyglutamic acid is preferably used. A sodium salt or a potassium salt of a natural? Or? -Polyglutamic acid obtained as a fermentation product from chemically synthesized? Or? -Polyglutamic acid or various strains is preferable, and a natural polyglutamate is particularly preferable, and productivity as a raw material This higher? -Polyglutamate salt is more preferable.

The viscosity of the polyglutamic acid salt is not particularly limited, but it is preferable that the viscosity (25 캜) of the 4% aqueous solution by the measuring method using a B-type viscometer described later is in the range of 10 to 200 mPa · s, particularly 30 to 150 mPa · s. If it is not satisfied with 10 mPa 占 퐏, there is not enough saliva secretion ratio and the sulphure elimination effect may not be sufficiently manifested. In addition, the unpleasant taste and the oral mucous membrane stimulation may not be sufficiently reduced or suppressed. If the viscosity is more than 200 mPa · s, the viscosity of the preparation becomes high, and the dispersibility in the mouth becomes poor, so that sufficient effect may not be exhibited.

Viscosity measurement

To a 200 mL beaker, 96 g of water is added, and 4.0 g of? -Polyglutamate is added to the mixture while stirring with a stirrer to dissolve completely. Then, after standing for 1 hour in a constant-temperature water bath at 25 占 폚, the viscosity is measured accurately after one minute using a BL-type viscometer.

BL type viscometer: TOKYO KEIKI INC. Type B Viscometer type BL

Rotor: No. 2 Number of revolutions: 60 rpm Measuring temperature: 25 캜

The blending amount of the polyglutamate salt as the component (B) is preferably from 0.05 to 5%, more preferably from 0.1 to 2%, of the whole composition. If the amount is less than 0.05%, the unpleasant taste of the glycerin fatty acid ester and the oral mucous membrane irritation can not be suppressed, or the secretion promotion of the saliva is insufficient, so that the adhesion inhibiting effect of the spermatozoa may not be satisfactorily expressed. If the content is more than 5%, the viscosity of the preparation becomes high, and the preparation becomes difficult to spread widely throughout the mouth, and the adhesion inhibiting effect of the stick may not be sufficiently manifested.

The blending ratio of the component (B) to the component (A) is 0.1 to 150, preferably 0.2 to 15, in terms of the mass ratio of (B) / (A). When the ratio of (B) / (A) is less than 0.1, the unpleasant taste and the oral mucous membrane stimulation can not sufficiently be reduced or suppressed even if the amounts of the components (A) and (B) If it is more than 150, the viscosity of the preparation increases and the dispersibility in the mouth becomes poor, and sufficient effect is not produced.

The oral composition of the present invention is liquid or liquid. Here, the liquid oral composition is a transparent or semi-transparent preparation in which the compounding ingredients are solubilized. Solid components that are not solubilized, such as an abrasive, are not usually compounded, and may contain, for example, a wetting agent, a surfactant, , Perfume, active ingredient and the like. The liquid oral composition may be a gel-like preparation having low fluidity due to low formability, and solid components such as abrasives may be dispersed without being solubilized. For example, an abrasive, a wetting agent, a thickening agent, a surfactant, a solvent, and a sweetening agent, a flavoring agent, an effective ingredient and the like are mixed as needed.

The composition of the present invention is preferably used so that it can be directly applied to the tongue surface by spraying, dripping onto the surface of the tongue, or scraping the inside of the mouth, and the surface of the tongue may be brushed with a toothbrush after use. The dosage form is preferably a dosage form suitable for such use. Specifically, it can be used as a formulation such as a dentifrice such as a mouthwash, a liquid dentifrice, a liquid toothpaste, a spray, a dropping agent, a capsule, It is particularly preferable to use it as a spraying agent or dropping agent from the standpoint of portability in which an appropriate amount can be freely used and the like.

Other known components other than the components (A) and (B) may be blended as required in the composition of the present invention insofar as the effect of the present invention is not hindered depending on the form or formulation, It can be prepared by a conventional method.

As the abrasive, an abrasive generally used in a composition for oral cavity can be used. Specific examples thereof include silica-based abrasives such as precipitated silica and aluminosilicate, calcium phosphate dihydrate and anhydride, calcium phosphate compounds such as calcium phosphate monobasic, calcium phosphate and calcium pyrophosphate, calcium carbonate, Calcium, and an aluminum hydroxide salt may be blended (the blending amount is usually 0 to 50%, particularly 10 to 50%).

As the surfactant, an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant can be mixed.

Examples of the anionic surfactant include sodium alkylsulfate such as sodium laurylsulfate and sodium myristylsulfate, N-acylsarcosine sodium such as N-lauroylsarcosine sodium and N-myristoyl sarcosine, and the like.

Examples of the nonionic surfactant include sugar alcohol fatty acid esters such as polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and sucrose fatty acid esters, polyhydric alcohols such as polyoxyethylene glycerin fatty acid esters and polyethylene glycol fatty acid esters Ether type or ester type surfactants such as fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers and polyoxyethylene alkyl phenyl ethers, and fatty acid alkanolamides such as lauric acid diethanolamide are listed do. Examples of the cationic surfactant include alkylammonium, alkylbenzylammonium salts and the like.

Examples of amphoteric surfactants include betaine acetate type amphoteric surfactants, imidazoline type amphoteric surfactants and the like.

The blending amount of these surfactants may be 0 to 10%, particularly 0.1 to 5.0%.

Examples of the thickening agent include xanthan gum, carrageenan, hydroxyethylcellulose, sodium alginate, polyvinyl alcohol, carboxymethylcellulose sodium and the like (the blending amount is usually 0 to 5%, particularly 0.5 to 3%).

Examples of the humectant include sugar alcohols such as sorbitol, maltitol and lactitol, and polyhydric alcohols such as glycerin, ethylene glycol, polyethylene glycol, propylene glycol and 1,3-butylene glycol (the blending amount is usually 2 to 70%). .

As the solvent, water is usually used, and its content can be 20% or more. Alcohols such as lower monohydric alcohols having 2 to 4 carbon atoms such as ethanol, isopropanol, butanol, and propanol may also be blended, and the blending amount may be 0 to 20%.

As the sweetening agent, xylitol, maltitol, saccharin, sodium saccharin, stevioside, aspartame and the like can be mixed.

As a coloring agent, a water-soluble coloring matter having high stability such as blue No. 1, green No. 3, No. 4 No. 4, No. No. No. No. 105 or the like may be added.

In addition, citric acid, malic acid, tartaric acid, succinic acid or a salt thereof, phosphoric acid, a phosphate (sodium dihydrogenphosphate, disodium hydrogenphosphate, trihydroxyphosphate, etc.), carbonate, bicarbonate or the like may be added as a pH adjuster.

The pH of the composition is preferably 3 to 10, particularly 5 to 8.

Examples of the fragrance include fragrance oils such as peppermint oil, spearmint oil, eucalyptus oil, green tea oil, clove oil, time oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, Natural essential oils and natural oils such as I-menthol, I-carbon, cinnamic aldehyde, orange oil, anethole, 1,8-cineol, methyl salicylate, A perfume ingredient contained in the natural essential oil such as citral, camphor, borneol, pinene, and spirintol, and a perfume ingredient such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenyl, methyl anthranilate, Ethyl-p-menthane-3-carboxamide, menthyllactate, ethylenevinylene, ethylenevinylene, ethylenevinylene, fumarate, Glycol-1-menthyl carbonate and the like Or a combination flavor of a combination of several fragrance ingredients or natural essential oils such as apple, banana, strawberry, blueberry, melon, pitch, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt do. These may be used alone or in combination of two or more in a range not hindering the effect of the present invention, and may be blended in an amount of usually 0.00001 to 3% in the composition.

Examples of the active ingredient include cationic fungicides such as cetylpyridinium chloride, chlorohexidine hydrochloride, chlorohexidine gluconate, benzalkonium chloride and benzethonium chloride, nonionic fungicides such as isopropylmethylphenol, Dextrinase and mutagen, enzymes such as dextranase and mutanase, fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride, vitamin C such as ascorbic acid, dihydrocholesterol , Plant extracts such as glycyrrhetin salts, glycyrrhetinic acid, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, time, golden, clove, hammamelis, gland gluconate, caropeptide, sodium polyphosphate, Compounds, polyvinylpyrrolidone, anti-calculus agents, anti-drip agents, potassium nitrate, aluminum lactate, and the like. The amount of the active ingredient to be added may be within a range that does not interfere with the effect of the present invention.

The container can be a well-known container suitable for receiving the oral composition. Materials such as polyethylene, polypropylene, polyethylene terephthalate, and polyacetal are listed, and a container according to the formulation is used.

The spray agent is not particularly limited as far as it is a container having a structure capable of spraying a medicament. More specifically, the present invention relates to a spraying device comprising a container body such as a plastic bottle for containing contents and a spraying portion having a spraying mechanism such as a pump dispenser, and spraying the sprayed portion by pressing the pressing portion of the sprayed portion closely fitted to the upper opening portion of the container body, A vessel for spraying by pressing the container body to be accommodated, or the like can be used.

The dropping agent is not particularly limited as long as it is a liquid droplet that has a structure applicable to the oral cavity, particularly to the surface of the tongue. It is possible to use a nozzle cap for dropping, press the container body to make a droplet, a droplet having a dropper, and the like.

In the present invention, there is provided a method for producing an anti-adherence agent which comprises (A) a glycerin fatty acid ester having 8 to 14 carbon atoms in fatty acid and (B) a polyglutarate salt, wherein the component (B) . In this case, the details of the compounding ingredients, the amount thereof, and the ratios are the same as described above.

(Example)

EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples, "%" means% by mass unless otherwise specified. The following viscosities are values measured by a B-type viscometer in the same manner as described above.

[Examples 1 to 18 and Comparative Examples 1 to 6]

The oral compositions having the compositions shown in Tables 1 to 4 were prepared in the following manner, and the following evaluations were carried out. The results are shown in Tables 1-4.

<Preparation of formulation>

Each component was weighed and prepared by mixing with a stirrer. Approximately 30 mL of the prepared solution was filled in a spray container (manufactured by Yoshino Kogyosho, Y-70 dispenser, volume 30 mL, made of polyethylene terephthalate) to obtain a test preparation.

&Lt; Evaluation of inhibition of sticking adhesion, feeling of use (taste), evaluation of oral mucosal irritation &

We carried out tests by ten panelists who felt dullness of mouth from usual. First, the expert cleans the panel's surface using a toothbrush, and then started the test. The test formulation was sprayed 5 times toward the tongue. 6 times a day to 10 times for 2 days were used. During the test period, cleaning of the tongue and the use of the mouthwash and mouthwash were discontinued. After completion of the test, a person in charge of the tongue of the panel observed, and the ratio (%) of the area covered with the suture was calculated. The average of the panel was evaluated as?

The feeling of use (taste) and oral mucous membrane irritation were evaluated by the panel itself by the following criteria (step 7), and the average value of the ratings was calculated.

Evaluation criteria for inhibition of sulcus adhesion;

  ◎ 0 to less than 15%

  ○ 15% or more and less than 30%

  △ 30% or more and less than 40%

  × 40% or more

Evaluation criteria of feeling (taste);

  7 points I do not feel unpleasant already

  6 points Almost nasty I do not feel

  5 points Not feel so nasty already

  4 points I can not say either

  3 points I feel a bit nasty already

  2 points I feel pretty nasty already

  1 point Very unpleasant feeling already

Evaluation criteria for oral mucosal irritation;

  7 points No stimulation at all

  6 points Almost no stimulation

  5 points Not much stimulation

  4 points I can not say either

  3 points I feel a little irritation

  2 points Feeling quite stimulating

  1 point I feel very irritation

The average value of the ratings of each evaluation was calculated and judged as the following evaluation criteria.

  ◎ 6 points or more

  ○ 4.5 points or more and less than 6 points

  △ 3.5 or more and less than 4.5 points

  × 3.5 or less

[Examples 19 to 31]

An oral composition having the compositions shown in Tables 5 to 7 was prepared in the same manner as described above. Examples 19 to 23 were filled in the spray container as described above and filled in a dropping container (manufactured by Nichiei Plastics, essence series DE 20, material: polyethylene, 20 mL) for Examples 24 to 28, To 31 were filled in three reservoirs (made by Yoshino Kogyosho, made of polyethylene terephthalate, 250 mL) and evaluated by the above evaluation method.

As for the dropping agent, 3 drops were applied to the tongue after removing the suture in the same manner as in the evaluation of the effect of inhibiting the adhesion of the suture, and after removal of the suture, After being aged for about 30 seconds, it was used as a discharging method and evaluated by the above-mentioned method. The results are shown in Tables 5 to 7.

Details of the materials used are as follows.

Glyceryl caprylate: Taiyo Kagaku Co., Ltd. Production, product name SunSoft 700P-2

Capric acid glyceryl: Taiyo Kagaku Co., Ltd. Production, Line Soft 760

Glyceryl undecylenic acid: manufactured by Nikko Chemicals Co., Ltd. Manufactured by NIKKOL MGU

Lauric acid glyceryl: Taiyo Kagaku Co., Ltd. Production, product name Sun soft 750

Glyceryl palmitate: Nihon-emulsion Co., Ltd. Manufactured by GMS-P

Sodium polyglutamate: Meiji Food Materia Co., LTD. Manufactured by Meiji Polyglutamic Acid, viscosity is as described in the table.

Potassium polyglutamate: Meiji Food Materia Co., LTD. Production and viscosity are as described in the table.

Sodium pyrophosphate: Taihei Chemical Industrial Co., Ltd. making

As fragrant materials A to F, those shown in Tables 8 to 14 were used.

In the table, parts are parts by mass (hereinafter the same).

Claims (6)

(B) a component / (A) in a mass ratio of from 0.1 to 5 mass%, (B) from 0.01 to 2 mass% of (A) a glycerin fatty acid ester having 8 to 14 carbon atoms in the fatty acid, Lt; RTI ID = 0.0 &gt; 150. &Lt; / RTI &gt; The method according to claim 1,
Wherein the component (A) is a glycerin fatty acid ester having 8 to 11 carbon atoms in the fatty acid. 3. The method according to claim 1 or 2,
Wherein the component (A) is at least one member selected from the group consisting of glyceryl caprylate, glyceryl caprate and glyceryl undecylenate. 3. The method according to claim 1 or 2,
Wherein the component (B) / (A) is in a range of 0.2 to 15 in mass ratio. 3. The method according to claim 1 or 2,
Wherein the composition is applied to the tongue surface by spraying or dripping into the mouth, or by subginging in the oral cavity. (A) a glycerin fatty acid ester having 8 to 14 carbon atoms in fatty acid, and (B) 0.05 to 5 mass% of a polyglutamate, wherein the component (B) / the component (A) By weight based on the total weight of the composition.