JP6031979B2 - Liquid oral composition - Google Patents

Description

  The present invention is excellent in the effect of imparting a cleaning feeling while washing dirt in the mouth, has a clear formulation appearance that is stably maintained over time, and has a good feeling of use and is particularly suitable as a mouthwash. The present invention relates to a liquid oral composition.

  In the mouth after meal, dirt such as oil and protein derived from meal and saliva and bacteria are mixed, and it is difficult to wash away the dirt remaining on the teeth and oral mucous membrane of the mouth simply by rinsing with water. Therefore, it was not possible to give a refreshing cleaning feeling after brushing just by rinsing the mouth using a liquid oral composition such as a mouthwash.

  On the other hand, in a liquid oral composition, if a lot of surfactant is added for the purpose of removing oil and protein, a tingling sensation to the oral mucosa, mucous membrane roughening and peeling occur, and the bitterness and astringency are strong. There is a problem that the palatability is lowered, and there is a problem that the preparation immediately after preparation or after low-temperature storage is garbled or sprinkled. For this reason, the improvement of the cleaning feeling imparting effect of the liquid oral cavity composition has been a problem.

  Patent Document 1 discloses an oral composition containing an anionic surfactant, a nonionic surfactant, an imidazolinium betaine-type amphoteric surfactant as an amphoteric surfactant, and the like, and no abrasive. It has been proposed that a foamy oral composition filled in an aerosol-type non-gas container has high penetrability and penetrates into every corner of the oral cavity. However, this is a liquid composition having a low surface tension that has been jetted out of the container and used in the form of foam to improve the permeability, and is intended to improve the cleaning feeling of the liquid oral composition. is not.

  Patent Document 2 includes a nonionic surfactant, an anionic surfactant, a surfactant system containing an amphoteric surfactant and a liquid carrier, and an oral cavity suitable for cleaning an oral cavity having a specific bubble size distribution. A liquid gel dentifrice composition that combines the effects of both toothpaste and gargle and has a sufficient foaming performance, a gel that provides a toothpaste-like sensation after removal from the mouth Or a liquid gel mouthwash is disclosed. However, Patent Document 2 is a technique relating to a gel preparation containing water-insoluble fine particles, and no mention is made regarding the cleaning feeling of a liquid preparation.

Japanese Patent Laid-Open No. 11-130647 JP 2011-213723 A

  Therefore, in the liquid oral composition, it is a technical problem of the present invention to wash the dirt in the mouth and to give a high cleaning feeling imparting effect.

  The present invention has been made in view of the above circumstances, and is excellent in cleaning feeling imparting effect while cleaning the dirt in the mouth, and the clear formulation appearance is stably maintained over time, and there is no sense of incongruity and good usability. It aims at providing the composition for liquid oral cavity which has.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) 0.5 to 2% by mass of a divalent or higher carboxylic acid or salt thereof, and (B) an anionic surfactant in an amount of 0. With the liquid oral composition comprising 03 to 0.2% by mass and (C) 0.05 to 1% by mass of an amphoteric surfactant, the dirt in the mouth is washed and the cleaning feeling imparting effect is excellent. It was found that just rinsing the mouth can give the same high cleaning feeling as after brushing. It has also been found that a clear formulation appearance can be stably maintained over time, and a good feeling of use can be secured without giving a sense of incongruity when it is contained in the mouth.

  According to the present invention, by properly combining the components (A), (B), and (C), the cleaning effect imparting effect of the liquid preparation is remarkably improved. It is possible to give a high cleaning feeling that the user can feel that the remaining dirt has been removed and refreshed as when the teeth are brushed. In addition, the use of the product immediately after preparation of the preparation, the orientation after storage at low temperature, and the dust are suppressed, the clear appearance immediately after preparation is stably maintained over time, and the discomfort when contained in the mouth is suppressed, so that it can be used gently. A liquid preparation with a feeling is obtained.

The composition of the present invention preferably has a total content of (B) anionic surfactant and (C) amphoteric surfactant of 0.5% by mass or less of the total composition, The content is 1.0% by mass or less of the entire composition, and indicates the ratio of the total content of the components (B) and (C) to the content of the component (A) ((B) + (C) ) / (A) is preferably 0.1 to 1.5 as a mass ratio, and can be suitably prepared as a non-foaming mouthwash.
According to the present invention, even if the amount of the surfactant is small as described above, a high cleaning feeling imparting effect can be obtained and the above-described special effects can be obtained.

Therefore, the present invention
(A) and 0.6 to 2 wt% of citric acid or a salt thereof,
(B) 0.05 to 0.2% by mass of sodium lauryl sulfate ,
(C) 0.08 to 0.2 % by mass of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine ;
A pH adjuster selected from sodium hydroxide and potassium hydroxide, and the ratio of the total content of the components (B) and (C) to the content of the component (A) ((B) + (C)) / (a ) is from 0.16 to 0.35 as a mass ratio, provides a mouthwash composition pH at 25 ° C. is characterized 5.5 to 7 der Rukoto.

  According to the present invention, it is excellent in the effect of imparting a washing sensation while washing dirt in the mouth, and the clear appearance of the formulation is stably maintained over time, and there is no sense of incongruity and a good feeling of use. As a liquid oral composition, it can be provided.

  The present invention will be described in further detail below. The composition for liquid oral cavity of the present invention contains (A) a divalent or higher carboxylic acid or a salt thereof, (B) an anionic surfactant, and (C) an amphoteric surfactant in an appropriate amount. Features.

  (A) The divalent or higher carboxylic acid or a salt thereof is not particularly limited as long as it can be blended in the oral composition, but a divalent or trivalent carboxylic acid or a salt thereof is suitable. Examples thereof include carboxylic acids selected from citric acid, malic acid, tartaric acid, and succinic acid, or salts thereof. Specifically, one of citric acid, sodium citrate, malic acid, tartaric acid, succinic acid and the like can be used alone or in combination of two or more in terms of effect expression. Acid, sodium citrate.

  (A) The compounding quantity of the carboxylic acid of the component or its salt is 0.5 to 2% (mass%, the following is similar) of the whole composition, Preferably it is 0.8 to 2%, More preferably, it is 0.8. 8 to 1.2%. If it is less than 0.5%, the cleaning effect imparting effect is poor. If it exceeds 2%, the effect of imparting a cleaning feeling is inferior, and the clarity of the preparation and the appearance stability after low-temperature storage cannot be ensured, resulting in an uncomfortable feeling and poor usability.

  In the present invention, it is possible to improve the effect of imparting cleaning feeling by combining (A) component with (B) and (C) components in appropriate amounts. When (B) component is missing, or (C) component When lacking, it is inferior to the effect of imparting cleaning feeling. Further, the clarity of the preparation and the appearance stability after low-temperature storage are poor.

  (B) Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, N-acyl sarcosine salts such as sodium lauroyl sarcosine, sodium N-lauroyl sarcosine, and sodium N-myristoyl-L-glutamate. N-acyl glutamate such as Of these, alkyl sulfates are preferred, and sodium lauryl sulfate is more preferred because of the excellent cleaning feeling imparting effect after rinsing, appearance stability after low-temperature storage, and uncomfortable feeling when contained in the mouth.

  (B) The compounding quantity of the anionic surfactant of a component is 0.03-0.2% of the whole composition, Preferably it is 0.05-0.15%. If it is less than 0.03%, the cleaning feeling imparting effect is poor. If it exceeds 0.2%, it will not be possible to ensure the appearance stability after storage at low temperature and the feeling of strangeness.

  (C) As the amphoteric surfactant, a betaine-type amphoteric surfactant is used. Examples include imidazoline types such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, fatty acid amide betaine types such as coconut oil fatty acid amidopropyl betaine, and betaine acetate types such as lauryldimethylaminoacetic acid betaine. It is done. In particular, an imidazoline type such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine is preferable because it provides an effect of imparting a cleaning feeling after rinsing and an uncomfortable feeling when contained in the mouth.

  The blending amount of the amphoteric surfactant as the component (C) is 0.05 to 1%, preferably 0.08 to 0.2% of the entire composition, and is within this range. In addition, the clarity of the preparation and the appearance stability after low-temperature storage can be secured, and the uncomfortable feeling can be suppressed. If it is less than 0.05%, the effect of imparting cleaning sensation cannot be improved, and if it exceeds 1%, the effect of imparting cleaning sensation is reduced, and the appearance stability after low-temperature storage and the feeling of discomfort may be inferior.

  In addition, the total blending amount of the components (B) and (C) is 1.2% or less of the whole composition, but particularly 0.5% or less from the viewpoint of appearance stability after low-temperature storage and uncomfortable feeling. Is preferable, more preferably 0.4% or less, and still more preferably 0.3% or less. The lower limit is 0.08% or more, preferably 0.16% or more.

  Furthermore, in this invention, ((B) + (C)) / (A) which shows the ratio of the total content of (B) and (C) component with respect to content of (A) component is 0.1 as mass ratio. It is preferable that it is -1.5, More preferably, it is 0.16-0.35, and it is excellent by the said effect in it being this range. If it is less than 0.1, it may not be possible to ensure clarity immediately afterwards, appearance stability after low-temperature storage, and lack of discomfort when contained in the mouth. If it exceeds 1.5, the effect of imparting a washing sensation after rinsing cannot be obtained, the appearance stability after low-temperature storage cannot be ensured, and the sense of discomfort when contained in the mouth may not be suppressed.

  The composition of the present invention is prepared as a clear, non-foamed liquid oral composition, particularly a mouthwash, in which the ingredients are solubilized. Specifically, it can be prepared and applied as a mouthwash of a type that is used as it is, a mouthwash that is diluted with a concentrated type, a mouth freshener, a liquid dentifrice, and the like.

  In addition to the above components, the liquid oral composition of the present invention can contain other known components as necessary within a range that does not interfere with the effects of the present invention. Specific examples include a wetting agent, a surfactant, a solvent, and a sweetener, a colorant, a fragrance, and an active ingredient as necessary. In addition, solid oral components such as abrasives and water-insoluble components are not usually blended in liquid oral compositions, particularly mouthwashes, and these components, particularly abrasives, are not included in the composition of the present invention. It is preferable not to blend.

  Examples of the wetting agent include sugar alcohols such as sorbitol, malt, and lactit, and polyhydric alcohols such as glycerin, ethylene glycol, and polyethylene glycol. The blending amount of these wetting agents is preferably 2 to 20% of the entire composition.

As the surfactant, in addition to the components (B) and (C), a known nonionic surfactant can be further blended.
Nonionic surfactants include, for example, sugar alcohol fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, and alkylol amide. And polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, hexaglyceryl monocetylate, fatty acid diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether and the like.
Furthermore, you may mix | blend a cationic surfactant. Examples of the cationic surfactant include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride and the like.
About 0 to 2% of the surfactant can be blended.

  In the composition of the present invention, the total amount of the surfactants including the components (B) and (C) is preferably 0.08 to 3%, particularly preferably 0.16 to 2%, more preferably the whole composition. Is 1.0% or less, more preferably 0.16 to 1.0%. When the total amount of surfactants in the composition is 1.0% or less, the appearance stability after low-temperature storage is excellent, the uncomfortable feeling when contained in the mouth is suppressed, and it is particularly suitable for giving the effect of the present invention. .

As a sweetening agent, xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame and the like can be blended.
As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and the like can be added.

  As a fragrance, natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, lavender oil, paracres oil, And l-menthol, l-carvone, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, eugenol, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Perfume ingredients contained in natural essential oils, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde Perfume ingredients such as, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate, One of the flavors of apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. Or 2 or more types can be added in the range which does not inhibit the effect of this invention. The addition amount is usually 0.00001 to 3% in the composition.

  Active ingredients include, for example, bactericides such as isopropyl methyl cellulose, enzymes such as dextranase and mutanase, fluorides such as sodium fluoride and sodium monofluorophosphate, aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid Such as vitamin C, dihydrocholesterol, glycyrrhetin salts, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, ougon, clove, hamamelis, etc. plant extracts, copper gluconate, caropeptide, sodium polyphosphate, water-soluble inorganic phosphate compounds Polyvinyl pyrrolidone, calculus inhibitor, dental plaque inhibitor, potassium nitrate, aluminum lactate and the like can be added. In addition, the addition amount of these active ingredients can be made into effective amount in the range which does not prevent the effect of this invention.

  As the solvent, water is usually used, and the water content is preferably 60% or more of the entire composition. Further, a lower monohydric alcohol such as ethanol may be blended within a range not impeding the effects of the present invention, but when added, it is preferably 10% or less of the entire composition. In addition, it is preferable not to mix | blend ethanol which gives irritation from the point of use feeling.

  The pH of the composition may vary, but the pH at 25 ° C. is preferably 5.5 to 7.5, more preferably 6 to 7. When the pH is within this range, the effect of imparting a washing sensation is more excellent, the low-temperature storage stability of the appearance of the preparation is good, the uncomfortable feeling is further suppressed, and the usability can be further improved.

  If necessary, the pH may be adjusted using a pH adjuster, and examples of the pH adjuster include sodium hydroxide, hydrochloric acid, sodium carbonate, sodium hydrogen carbonate, boric acid or a salt thereof, Sodium oxide, potassium hydroxide and hydrochloric acid are preferred. The blending amount of these pH adjusters only needs to adjust the pH value within the above range.

  The method for using the liquid oral composition of the present invention is not particularly defined, but it is preferably applied by rinsing the mouth for 10 to 30 seconds, particularly about 20 seconds, including an appropriate amount in the mouth. The teeth may be brushed if necessary after mouthwashing, but a sufficient cleaning feeling can be imparted without brushing, and when brushing it is necessary to use a toothbrush, Mouthwashing without brushing is more preferred in terms of labor.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% indicates mass% unless otherwise noted. The pH was measured immediately after preparation using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd., and showed a value after 3 minutes at 25 ° C.

[Examples and Comparative Examples]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by the following method. The obtained liquid oral composition was evaluated by the following methods. The results are shown in Tables 1-3.

(1) Preparation Method of Liquid Oral Composition The liquid oral composition was prepared by sequentially adding raw materials into purified water according to the composition in the table and stirring to dissolve them uniformly. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.

(2) Evaluation of effect of imparting cleaning feeling The sensory evaluation was carried out by 10 subjects according to the following criteria for the cleaning feeling in the mouth after about 10 mL of the composition immediately after preparation was rinsed and discharged for about 20 seconds. The average value was obtained and judged based on the following criteria, and the cleaning feeling imparting effect was evaluated.
Here, the cleaning feeling is the feeling that dirt remaining on the teeth, oral mucosa and the like has been removed and refreshed as when the teeth are brushed, and is equivalent to that after brushing.
Criteria for evaluating mouth washing after rinsing 4: There was a feeling of washing as high as after normal brushing.
3: A feeling of washing was felt although not as much as after normal brushing.
2: A feeling of washing was hardly felt.
1: A feeling of washing was not felt.
Criteria for cleaning effect imparting effect ◎: 3.5 points or more ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

(3) Evaluation of clarity immediately after preparation of preparation The composition immediately after preparation was filled in a 250 mL PET (polyethylene terephthalate) container in a full injection amount, and compared with a PET container (control product) filled with purified water as follows. Visual judgment was made according to the standard.
Evaluation criteria for clarity immediately after preparation ◎: No dust is observed and clear ○: Slight dust is observed, but it is a level that cannot be distinguished without a control product, and clarity is not a problem △: Scratch Obviously recognized and slightly garbled even without control product x: Obviously garbled even without comparison with control product, so that it is difficult to see through the PET container

(4) Evaluation of appearance stability after low-temperature storage 250 mL of a composition immediately after preparation was filled in a 250 mL PET container, stored at −5 ° C. for 1 month, returned to room temperature, The orientation when gently displaced was determined by visual comparison with a PET container (control product) filled with purified water, and the restraining effect of orientation and dirt was evaluated according to the following criteria. From this evaluation result, the appearance stability after low-temperature storage was evaluated, and B or higher was regarded as acceptable.
Evaluation criteria for the effect of restraining odor and dust ◎: No crisp and dirty dust is observed and clear ○: Slightly observed odor and dust are at a level that cannot be determined without a control product, and clarity is not a problem Δ: Orientation and dirt are clearly recognized, and even if there is no control product, orientation and dirt are slightly recognized. ×: Orientation and motion are clearly recognized without comparison with the control product, and the other side of the PET container is watermarked. It is so hard to see

(5) Evaluation of no sense of incongruity when put in mouth By 10 subjects with sensitive oral mucosa, about 10 mL of the composition immediately after preparation is contained in the mouth, and the mouth feels uncomfortable while rinsing for about 20 seconds. Was subjected to sensory evaluation according to the following criteria, and an average value was determined and judged according to the following criteria.
Evaluation Criteria for No Discomfort When Ingested 4: The discomfort was low.
3: The level of discomfort was low and there was no problem.
2: A sense of incongruity was felt.
1: Remarkable discomfort was felt.
Criteria ◎: 3.5 points or more ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

Details of the raw materials used are as follows.
Citric acid: Fuso Chemical Industry Co., Ltd. Malic acid: Fuso Chemical Industry Co., Ltd. Tartaric acid: Fuso Chemical Industry Co., Ltd. Succinic acid: Fuso Chemical Industry Co., Ltd. 2-alkyl-N-carboxymethyl-N- Hydroxyethyl imidazolinium betaine: Lion Co., Ltd., Enacol C-40H, 30% aqueous solution palm oil fatty acid amide propyl betaine: Lion Co., Ltd., Enacol C-30B, 30% aqueous solution lauryldimethylaminoacetate betaine: Nikko Chemicals NIKKOL AM-301, manufactured by Nikko Corporation
Sodium lauryl sulfate: Lauroyl sarcosine sodium manufactured by Toho Chemical Industry Co., Ltd .: N-myristoyl-L-glutamate sodium manufactured by Kawaken Fine Chemical Co., Ltd .: Amino Surfact AMMS-P1 manufactured by Asahi Kasei Chemicals Co., Ltd.
Sodium hydroxide: manufactured by Kanto Chemical Co., Inc., diluted with sodium hydroxide special grade to 10% and blended Note that, unless otherwise specified, the blending amounts in the table are pure conversion values.

Claims (3)

(A) and 0.6 to 2 wt% of citric acid or a salt thereof,
(B) 0.05 to 0.2% by mass of sodium lauryl sulfate ,
(C) 0.08 to 0.2 % by mass of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine ;
A pH adjuster selected from sodium hydroxide and potassium hydroxide, and the ratio of the total content of the components (B) and (C) to the content of the component (A) ((B) + (C)) / (a ) is from 0.16 to 0.35 as a mass ratio, mouthwash composition pH at 25 ° C. is characterized 5.5 to 7 der Rukoto. (B) the total content of sodium lauryl sulfate and the (C) 2-alkyl -N- carboxymethyl -N- hydroxyethyl imidazolinium betaine is from 0.16 to 0.4% by weight of the total composition, ( The mouthwash composition according to claim 1, wherein the total content of the surfactant including the components B) and (C) is 0.16 to 3 mass% of the entire composition. The mouthwash composition according to claim 1 or 2, wherein ethanol is not blended or the blending amount is 10% by mass or less when ethanol is blended.