CN116568269A

CN116568269A - Dentifrice composition

Info

Publication number: CN116568269A
Application number: CN202180082945.0A
Authority: CN
Inventors: 大国礼; 饭岛浩; 绵井大辅
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2020-12-22
Filing date: 2021-12-13
Publication date: 2023-08-08
Also published as: JPWO2022138256A1; WO2022138256A1

Abstract

The present invention provides a dentifrice composition containing an anionic surfactant, which has moderately suppressed foaming, low foamability and good feeling in use. A dentifrice composition comprising: the composition comprises (A) 1 or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acids and salts thereof, (B) 1 or more nonionic surfactants selected from fatty acid triglycerides and vegetable oils and animal oils which are liquid at 25 ℃, and (C), wherein the content of the component (B) is 0.05 to 1.5 mass%, and the mass ratio of (B)/(A) is 1 to 10.

Description

Dentifrice composition

Technical Field

The present invention relates to a dentifrice composition which moderately suppresses foaming, has low foamability and has good feeling in use.

Background

In general, a dentifrice composition is mixed with an abrasive, a surfactant, a humectant, a binder, and the like, and an anionic surfactant is mixed as a surfactant to exhibit a cleaning effect such as cleaning in the oral cavity, and further a bactericidal effect, whereby a fresh feeling in use in the oral cavity after brushing can be imparted.

However, for example, in the elderly people who need care of the dentifrice composition, the oral cavity function is lowered, and the after-brushing mouth cleaning is likely to be insufficient, and in many cases, the cleaning is performed by merely wiping the inside of the oral cavity with a wet wipe or the like when the mouth cleaning is difficult, so that the foam in the oral cavity is not sufficiently removed, and the irritating and unpleasant taste may be left.

However, even when an anionic surfactant is used in a small amount, the foaming property is high, and therefore, in order to suppress foaming of a dentifrice composition in which the anionic surfactant is mixed, it is necessary to add a large amount of a component having an antifoaming effect. The flavor components commonly used have an antifoaming effect, but these additives affect the feel of use of the dentifrice composition and limit the composition design, and therefore cannot impart a feel of use that suppresses foaming to a low foamability and ensures a feel of use to make the oral cavity fresh.

Prior art literature

Patent literature

Patent document 1: japanese patent laid-open No. 2005-289917

Patent document 2: japanese patent application laid-open No. 2015-89870

Patent document 3: japanese patent application laid-open No. 2015-231972

Disclosure of Invention

Problems to be solved by the invention

The present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition containing an anionic surfactant which is moderately suppressed in foaming, has low foamability, and is excellent in use feeling.

Means for solving the problems

As a result of intensive studies to achieve the above object, the present inventors have found that, when a specific amount of a fatty acid triglyceride or a specific vegetable oil or animal oil is mixed in a specific amount ratio with respect to the anionic surfactant in a dentifrice composition in which the specific anionic surfactant is mixed in combination with a nonionic surfactant, foaming can be moderately suppressed to a low foaming property and, even if foaming is hardly perceived, a fresh feeling (hereinafter, sometimes simply referred to as a fresh feeling) can be imparted to the oral cavity after brushing, and further, the stability of appearance can be ensured. That is, the dentifrice composition according to the present invention has been found to have a low foamability, a good feeling in use, and an appearance stability, in which foaming of the dentifrice composition comprising: the composition comprises (A) 1 or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acids and salts thereof, (B) 1 or more nonionic surfactants selected from fatty acid triglycerides, vegetable oils and animal oils which are liquid at 25 ℃, and (C), wherein the content of the component (B) is 0.05 to 1.5 mass%, and the mass ratio of (B)/(A) is 1 to 10.

In the present invention, if the component (C) is mixed in a combination of the component (A) and the specific amounts of the component (B) and the mass ratio of (B)/(A) within a specific range, the component (A) and the component (B) stably and specifically interact with each other, and the above-mentioned specific effects can be imparted.

In this case, in the present invention, by combining the components (a), (B) and (C), foaming property and foam persistence are suppressed while maintaining the effect such as the washing effect by the component (a), foaming is reduced, and the component (B) is stably mixed even after the lapse of time, whereby even with low foaming property with less foaming, a refreshing feeling can be imparted in the oral cavity after use, and also the stability of appearance can be ensured.

As shown in comparative examples described below, in comparative examples 1, 3 and 4 in which component (a) was mixed and component (B) was not mixed in the dentifrice composition, the foaming degree was poor even when liquid paraffin or shea butter was added together with component (C), and in comparative examples 5 and 6 in which components (a) and (B) were mixed and component (C) was not mixed, the appearance stability was poor even when the amphoteric surfactant cocofatty acid amidopropyl betaine was added. Even in comparative examples 7 and 8 in which the mass ratio of (B)/(A) was not proper, the foaming degree or the refreshing feeling was poor, and in comparative example 9 in which the amount of (B) was too large, the refreshing feeling and the appearance stability were poor. On the other hand, as shown in examples, the dentifrice composition in which the amounts of the components (a), (B) and (C) and the mass ratio of the component (B) to the component (B)/(a) of the present invention were in a specific range was excellent in foaming degree and also excellent in refreshing feeling and appearance stability.

Patent documents 1 to 3 disclose dentifrice compositions in which sucrose fatty acid esters or liquid oils and fats are mixed together with an anionic surfactant, but they do not inhibit foaming. In the present invention, it is difficult to consider from patent documents 1 to 3 that the combination system of the component (a) and the component (B) is used in combination, so that the foaming property is low and the feeling of use and the appearance stability are also ensured.

Accordingly, the present invention provides the following dentifrice compositions.

[ 1] A dentifrice composition comprising:

(A) An anionic surfactant selected from 1 or more than 2 of acyl taurines, acyl amino acids, alkyl sulfuric acids and salts thereof,

(B) Is selected from fatty acid triglyceride, vegetable oil which is liquid at 25deg.C, and more than 1 or 2 of animal oils

(C) A non-ionic surfactant, and a surfactant,

(B) The content of the components is 0.05 to 1.5 mass%, and the mass ratio of (B)/(A) is 1 to 10.

[ 2] the dentifrice composition according to [ 1], wherein the component (A) is selected from the group consisting of acyl amino acids and salts thereof.

The dentifrice composition according to [ 1] or [ 2], wherein the fatty acid triglyceride is a fatty acid triglyceride having 6 to 20 carbon atoms which is a liquid fatty acid at 25℃and the vegetable oil and animal oil which are liquid at 25℃are soybean oil, safflower oil, olive oil, avocado oil, maize germ oil, liver oil and shark oil.

The dentifrice composition according to any one of [ 1] to [ 3], wherein component (C) is a polyglycerin fatty acid ester having 12 to 18 carbon atoms of a fatty acid.

The dentifrice composition according to [ 5 ], wherein the polyglycerin fatty acid ester having 12 to 18 carbon atoms of the fatty acid is 1 or more selected from the group consisting of sixteen and ten-glyceride laurate.

The dentifrice composition according to any one of [ 1] to [ 5 ], which contains 0.05 to 1.5% by mass of the component (A) and 0.1 to 2% by mass of the component (C).

The dentifrice composition according to any one of [ 1] to [ 6 ], wherein the mass ratio of (C)/(B) is 0.5 to 5.

Effects of the invention

The present invention can provide a dentifrice composition containing an anionic surfactant, which has a low foamability and a good feeling in use, while moderately suppressing foaming. The dentifrice composition can remove foam in the oral cavity by only slightly rinsing or simply wiping after tooth brushing, can provide a cleaning effect by the component (A), can provide a fresh feeling in the oral cavity, and is effective as an oral care agent for a wide range of users.

Detailed Description

The present invention will be described in more detail below.

The dentifrice composition of the present invention contains (A) 1 or 2 or more anionic surfactants selected from acyl taurates, acyl amino acid salts and alkyl sulfates, (B) 1 or 2 or more surfactants selected from fatty acid triglycerides, vegetable oils and animal oils which are liquid at 25 ℃ and (C) nonionic surfactants.

(A) The component (C) is 1 or more than 2 anionic surfactants selected from acyl taurine, acyl amino acid, alkyl sulfuric acid and salts thereof.

Acyl taurine, acyl amino acid or salt thereof preferably has 8 to 18 carbon atoms in the acyl group, and alkyl sulfuric acid or salt thereof preferably has 8 to 12 carbon atoms in the alkyl group. These salts are preferably alkali metal salts such as sodium salts.

Examples of the component (a) include acyl amino acid salts such as sodium lauroyl sarcosinate and sodium cocoyl sarcosinate, acyl taurates such as sodium cocoyl methyl taurate and sodium cocoyl methyl taurate, alkyl sulfates such as sodium lauroyl sulfate and ammonium lauryl sulfate, and particularly, acyl amino acid salts are preferable from the viewpoint of suppressing foaming and refreshing feeling, and sodium lauroyl sarcosinate is more preferable.

(A) The mixing amount of the components is preferably 0.05 to 1.5% by mass (the same applies hereinafter), more preferably 0.1 to 1%, still more preferably 0.1 to 0.3% by mass of the entire composition. The more the amount of the mixture is, the more the refreshing feeling is sufficiently obtained, and when the amount of the mixture is 1.5% or less, foaming is sufficiently suppressed, and the foaming degree is excellent.

In addition, other anionic surfactants such as alkyl phosphates and polyoxyethylene monoalkyl phosphates may be mixed in the dentifrice composition of the present invention in addition to the component (a) within a range that does not hinder the effects of the present invention, but these arbitrary anionic surfactants may not be mixed.

(B) The components are 1 or more than 2 kinds selected from fatty acid triglyceride, vegetable oil which is liquid at 25deg.C, and animal oil. These substances serve as an antifoaming agent to maintain the effect such as the washing effect of the component (a), and to appropriately suppress foaming, thereby achieving a low foaming property.

As the component (B), any one of fatty acid triglyceride, vegetable oil which is liquid at 25 ℃ and animal oil which is liquid at 25 ℃ may be used, and from the viewpoint of the effect expression, two or three of them may be used in combination. Among them, from the viewpoint of the foaming degree, fatty acid triglycerides are preferable.

The fatty acid triglyceride is liquid at 25 ℃, and the carbon number of the fatty acid is 6-20. Fatty acid triglycerides of 8 to 10 are particularly preferred. For example, medium chain fatty acid triglycerides (a mixture of fatty acids having 8 and 10 carbon atoms) can be cited.

Examples of the vegetable oil and animal oil which are liquid at 25℃include vegetable oils such as soybean oil, safflower oil, olive oil, avocado oil and corn germ oil, and animal oils such as liver oil and shark oil, and vegetable oils are preferable from the viewpoint of foaming degree.

(B) The components may be used alone or in combination of 1 or more than 2, and commercially available ones may be used.

(B) The amount of the components to be mixed is 0.05 to 1.5%, preferably 0.1 to 1%, more preferably 0.1 to 0.5% of the total composition. When the mixing amount is less than 0.05%, the foaming degree is poor, and when it is more than 1.5%, the refreshing feeling is lowered, and further, the liquid separation or the like is caused after storage, and the appearance stability is deteriorated.

(C) The nonionic surfactant serves as a solubilizing agent, and also serves to stably mix the component (B) after storage and to impart appearance stability.

(C) Examples of the nonionic surfactant include glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil having 3 to 30 moles (particularly 5 to 20 moles) of ethylene oxide, polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and 2 to 40 moles (particularly 5 to 20 moles) of ethylene oxide, and polyoxyethylene sorbitan fatty acid ester. The glycerin fatty acid ester is preferably a glycerin fatty acid ester having 12 to 18 carbon atoms of a fatty acid, and specifically includes glycerin myristate, glycerin oleate, and the like. The polyglycerin fatty acid ester is preferably a fatty acid ester having 12 to 18 carbon atoms in fatty acid, and specifically includes sixteen lauric acid glyceride, ten oleic acid glyceride, ten pentaoleic acid glyceride, ten distearate and the like. Among them, from the viewpoint of appearance stability and further refreshing feeling, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers are preferable, and from the viewpoint of refreshing feeling, polyglycerin fatty acid esters are more preferable, and sixteen laurate and ten laurate are more preferable.

The nonionic surfactant may be used alone or in combination of 1 or more than 2, and commercially available ones may be used.

(C) The mixing amount of the components is preferably 0.1 to 2%, more preferably 0.2 to 1%, and even more preferably 0.2 to 0.7% of the entire composition. When the blending amount is 0.1% or more, the component (B) is stably blended even after storage, and the appearance stability can be sufficiently obtained. If it is 2% or less, no foaming and refreshing feeling can be sufficiently obtained. If the blending amount is more than 2%, foaming may not be suppressed and a refreshing feeling may not be sufficiently obtained.

The mass ratio of (B)/(A), which represents the ratio of the amount of the component (A) to the amount of the component (B), is 1 to 10, preferably 2 to 7, and more preferably 3 to 5. (B) When the mass ratio of/(a) is less than 1, foaming cannot be suppressed, and when it exceeds 10, the feeling of use becomes greasy, and a refreshing feeling cannot be obtained.

The ratio of the amount of the component (B) to the amount of the component (C)/(B) is preferably 0.5 to 5, more preferably 1 to 3. When the amount is within the above range, the foaming degree is more excellent, the refreshing feeling is more excellent, and the appearance stability is more excellent. (C) When the mass ratio/(B) is less than 0.5, the appearance stability may be lowered, and when it is more than 5, foaming may be difficult to suppress.

The dentifrice composition of the present invention may be formulated into various forms such as toothpaste, liquid dentifrice, wet-powder dentifrice, and the like, and is particularly suitable as toothpaste. In this case, appropriate known components may be mixed in addition to the above components depending on the purpose of the composition, the dosage form, and the like. For example, an abrasive, a wetting agent, a binder, a surfactant, and if necessary, a preservative, a sweetener, a coloring agent, a flavor, a pH adjuster, an active ingredient, and the like may be mixed, and these ingredients may be mixed with water to prepare the composition. These optional components may be mixed in usual amounts as needed. Hereinafter, the mixing amount is an amount relative to the whole composition.

Examples of the polishing agent include silica-based polishing agents such as anhydrous silicic acid, precipitated silica, aluminum silicate, and zirconium silicate, calcium phosphate-based compounds such as calcium hydrogen phosphate 2 hydrate and anhydrous compound, calcium carbonate, and synthetic resin-based polishing agents. The mixing amount of the polishing agent is preferably 0 to 50%, and the mixing amount is preferably 5 to 15%.

The dentifrice composition of the present invention can be prepared as a non-abrasive dentifrice without mixing an abrasive, and can obtain the effects of the present invention.

Examples of the humectant include sugar alcohols such as sorbitol and xylitol, and polyols such as glycerin and propylene glycol. The mixing amount of the wetting agent is usually 5 to 50%, particularly 10 to 30%.

The binder may be mixed with an organic or inorganic binder. Specifically, examples thereof include cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, and hydroxymethyl cellulose, alginic acid derivatives, gums such as xanthan gum, organic binders such as sodium polyacrylate, and inorganic binders such as thickening silica and thickening silica aluminum. The mixing amount of the binder is usually 0.1 to 10%.

In the present invention, the organic binder is particularly preferable, and the mixing amount of the organic binder is preferably 0.1 to 5%, and particularly preferably 0.5 to 3%.

Examples of the optional surfactant include cationic surfactants such as alkylammonium and alkylbenzyl ammonium salts, acetic acid betaine type surfactants such as alkylbetaine and fatty acid amidopropyl betaine, imidazolinium betaine type surfactants such as alkylimidazolinium betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine type surfactants.

The amount of the optional surfactant is 0 to 10%, preferably 0.001 to 10%, particularly preferably 0.1 to 5%.

Examples of the preservative include parabens such as methylparaben (methylparaben), benzoic acid, and salts thereof.

Examples of the sweetener include saccharin sodium.

Examples of the colorant include blue No. 1, yellow No. 4, and titanium dioxide.

The flavor may be a combination of natural flavors such as peppermint oil, spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, citrus oil, lime oil, lavender oil, rosemary oil, bay fruit oil, chamomile oil, caraway oil, marjoram oil, bay (Bay) oil, lemon grass oil, oregano (Origanum) oil, pine needle oil, orange flower oil, rose oil, jasmine oil, grapefruit oil, sweet pomelo (sweete) oil, grapefruit oil, iris extract, peppermint oil (absolute peppermint), rose absolute, orange flower, etc., and a processed (removed primary fraction, removed fraction, fractionation, liquid-liquid extraction, rectification, flavor powdering, etc.); and single-product fragrances such as menthol, carvone, anethole, eucalyptol, methyl salicylate, cinnamaldehyde, eugenol, 3-l-menthoxypropane-1, 2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, menthone, carvyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl epoxypropionate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methylcyclopentenone, furfural, trimethyl pyrazine, ethyl lactate, ethyl thioacetate, and the like; the known flavor materials used in dentifrice compositions, such as blended flavors, including strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mixed flavor, and tropical fruit flavor, are not limited to the flavors described in the examples.

The amount of the perfume to be mixed is not particularly limited, and the above-mentioned perfume raw material is preferably used in an amount of 0.000001 to 1% in the composition. The perfuming flavor using the above-mentioned flavor raw material is preferably used in an amount of 0.1 to 2% in the composition.

The pH adjuster may be added, and examples thereof include citric acid such as citric acid and sodium citrate, and salts thereof.

The effective components include fluorine-containing compounds such as sodium fluoride, sodium monofluorophosphate, nonionic bactericide such as isopropyl methylphenol, cationic bactericide such as cetyl pyridinium chloride, antiinflammatory agent such as tranexamic acid and allantoin, enzyme such as dextranase, water-soluble phosphoric acid compound, inorganic salts such as sodium chloride, potassium nitrate and aluminum lactate, vitamins such as ascorbic acid and tocopheryl acetate, plant extract, tartar inhibitor, etc. The effective components may be mixed in an effective amount within a range that does not hinder the effects of the present invention.

Examples (example)

The present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the examples. In the following examples,% represents% by mass unless otherwise specified.

Examples and comparative examples

Dentifrice compositions (toothpastes) having the compositions shown in tables 1 to 3 were prepared by a conventional method, and used as samples, and evaluated by the following methods. The results are also shown in the table.

Method for evaluating Using feel (foaming degree, refreshing feel)

For the sample immediately after preparation, evaluation of the feeling of use (degree of foaming, feeling of freshness) was performed by 5 professional panelists as subjects.

1g of the sample was placed on a toothbrush (clinica advantage toothbrush, 4 compact general type, manufactured by lion king Co., ltd.) and brushed for 3 minutes, and rinsed with water.

The foaming during use (during brushing) and the refreshing feeling in the oral cavity after use (after rinsing) were each determined based on the following score criteria. The average score of 5 persons was obtained, and the degree of foaming and the refreshing feeling were evaluated based on the following evaluation criteria.

Rating criteria for degree of foaming

5: hardly perceived foaming

4: a bit of foaming is perceived

3: slightly feel foaming

2: quite obvious feeling of foaming

1: very pronounced perceived foaming

Evaluation criteria for foaming degree (let O or above be acceptable)

The method comprises the following steps: the average score of 5 people is above 4.5 minutes

And (3) the following materials: the average score of 5 people is more than 4 and less than 4.5

O: the average score of 5 people is more than 3 and less than 4

X: average score of 5 people is less than 3 minutes

Rating criteria for refreshing feeling

5: obviously feel fresh and cool

4: feel fresh and cool

3: slightly feel a refreshing feeling

2: less feeling of refreshing

1: no refreshing feeling is felt at all

Evaluation criteria for refreshing feel (let O above as acceptable)

O: the average score of 5 people is more than 3 and less than 4

X: average score of 5 people is less than 3 minutes

< evaluation method of appearance stability >

The sample immediately after preparation was filled with 90g of the sample in a general aluminum laminate tube container, and after storage at 60℃for 1 month, the sample was extruded from the container, and the appearance of the preparation (whether or not liquid separation was present) was visually determined, and the appearance stability was evaluated on the basis of the following evaluation.

Evaluation criterion of appearance stability (let O or above be acceptable)

And (3) the following materials: completely free of liquid separation

O: a slight liquid separation is seen at the orifice, but at a level where there is no problem

X: visible liquid separation from the orifice to the interior

Details of the raw materials used are as follows.

(A) Composition of the components

Sodium lauroyl sarcosinate:

trade name manufactured by Chuanmin Fine chemical Co., ltd; SOYPON SLP

Sodium dodecyl sulfate:

trade name manufactured by BASF japan corporation; texapon OC-P

Sodium lauroyl methyltaurine:

trade name manufactured by solar chemical Co., ltd; NIKKKOL LMT

(B) Composition of the components

Fatty acid triglycerides:

( A mixture of fatty acids having 8 and 10 carbon atoms, and a composition ratio C8 of fatty acid carbon chains: 70%, C10:30% )

Trade name manufactured by NON SEINFORMATION; MCT-73

Olive oil:

trade name manufactured by solar chemical Co., ltd; NIKKKOL olive oil

Safflower oil:

trade name manufactured by solar chemical Co., ltd; NIKKKOL safflower oil

(B') liquid paraffin (comparative component):

trade name of Sanko corporation; liquid paraffin 350-S

(B') Shea butter (comparative ingredient):

manufactured by Croda japan, trade name; CROPURE SHEA BUTTER

(C) Composition of the components

Lauric acid decaglyceride:

trade name of sakazakii pharmaceutical industry (ltd): SY Glyster

Polyoxyethylene (20) hydrogenated castor oil:

japanese surfactant industry co (NIPPON SURFACTANT INDUSTRIES co., LTD), trade name: NIKKKOL HCO-20

Polyoxyethylene (5) stearyl ether:

lion Wang Hua, trade name: RHA-155SCE

(C') cocofatty acid amidopropyl betaine (30% aqueous solution) (comparative ingredient): trade name of Desoxel Co., ltd.: TEGO BETAIN CK-OK

In the table, the amounts of components (a) to (C), (B ') and (C') after conversion of the purity are shown.

TABLE 1

TABLE 2

TABLE 3

Claims

1. A dentifrice composition comprising:

(C) A non-ionic surfactant, and a surfactant,

2. The dentifrice composition of claim 1, wherein component (a) is selected from the group consisting of acyl amino acids and salts thereof.

3. The dentifrice composition according to claim 1 or 2, wherein the fatty acid triglyceride is a fatty acid triglyceride having 6 to 20 carbon atoms which is a liquid fatty acid at 25 ℃, and the vegetable oil and animal oil which are liquid at 25 ℃ are selected from the group consisting of soybean oil, safflower oil, olive oil, avocado oil, corn germ oil, liver oil and shark oil.

4. A dentifrice composition according to any one of claims 1 to 3 wherein component (C) is a polyglycerin fatty acid ester having 12 to 18 carbon atoms of a fatty acid.

5. The dentifrice composition according to claim 4, wherein the polyglycerin fatty acid ester having 12 to 18 carbon atoms is 1 or more selected from the group consisting of sixteen and ten-glyceride laurate.

6. The dentifrice composition according to any one of claims 1 to 5, comprising 0.05 to 1.5% by mass of component (a) and 0.1 to 2% by mass of component (C).

7. The dentifrice composition according to any one of claims 1 to 6, wherein (C)/(B) is 0.5 to 5 in mass ratio.