JPH11130647A - Foamy composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity having high dispensability of preparation and high permeability, permeating the preparation to every corner in an oral cavity, capable of efficiently preventing oral cavity diseases. SOLUTION: A composition for oral cavity containing >=0.1 wt.% based on the whole composition of a nonionic surfactant and one or more of an imidazolium betaine type ampholytic surfactant as an ampholytic surfactant, an acyl/dialkylethylenediamine derivative and an N-alkylamino acid derivative but not a polishing agent having <=35 dyne/cm surface tension is mixed with air by applying a pressing force to contents and packed into a nonaerosol type nongas normal-pressure container. A liquid dosage form can be made foamy in use, readily placed on a toothbrush and used. The composition has a good feeling in use by lubricating actions of foams. Since a proper amount of foams having excellent shape retention is continued, brushing is readily carried out for a long time. The composition has no problem with respect to time in use, safety and environmental aspects in waste treatment since a nongas normal- pressure container can be used.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a foamy oral composition in which a liquid oral composition is filled in a non-aerosol-type non-gas container and spouted out at the time of use to be applied. The present invention relates to a foamy oral composition having high permeability to details.

[0002]

2. Description of the Related Art Conventionally, liquid dentifrices have been known as mouthwashes having high dispersibility in the oral cavity. However, liquid dentifrices contain a liquid in the mouth. Alternatively, brushing is performed after spitting, so that the usability is not good. In addition, although it is a liquid, there is a problem that the surface tension of most preparations is high, and it is difficult for a drug or the like to penetrate into oral details.

[0003] On the other hand, toothpaste disperses in the mouth by mixing with saliva by brushing, and therefore has poor dispersibility as compared with liquid dosage forms. In addition, the foaming becomes strong over time, and it is difficult to brush for a long time.

[0004] In view of the above, the present applicant has first disclosed an anionic surfactant in an amount of 0.2% by weight or more of the whole composition and a nonionic surfactant or an amphoteric surfactant in an amount of 0.1 to 5% by weight.
And a liquid oral composition containing a viscous agent and / or a binder and having a viscosity of 7 poise or less at 25 ° C. without an abrasive, by applying a pressing force to the content to reduce the content. A foam-type oral composition characterized by being filled in a non-aerosol type non-gas atmospheric pressure container which is mixed with air and spouted out of the spout from the spout is proposed (JP-A-8-33).
No. 3226).

[0005] However, it is desired to further improve the properties (foam shape retention and uniformity) of foam when ejected from a foaming container and the permeability.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to meet the above-mentioned demands and as a result, have found that anionic surfactants, nonionic surfactants and amphoteric surfactants have been In this case, the amount of the anionic surfactant is 0.1% (% by weight, the same applies hereinafter) or more, and the amphoteric surfactant is an imidazolinium betaine type, an acyl / dialkylethylenediamine. Filling an oral composition having a surface tension of 35 dyn / cm or less obtained by using one or more selected from derivatives and N-alkylamino acid derivatives into a non-aerosol type non-gas atmospheric pressure container Due to the shape retention of the foam, having good foam properties uniformity, and high permeability,
The present inventors have found that the preparation permeates every corner of the oral cavity and in every detail, leading to the present invention.

Hereinafter, the present invention will be described in more detail. The foamy oral composition of the present invention comprises an anionic surfactant in an amount of 0.1% or more of the whole composition, a nonionic surfactant and an amphoteric surfactant. Oral composition containing an imidazolinium betaine-type amphoteric surfactant, one or more acyl / dialkylethylenediamine derivatives and N-alkylamino acid derivatives as an agent, and containing no abrasive having a surface tension of 35 dyn / cm or less. The material is filled in a non-aerosol type non-gas atmospheric pressure container which applies a pressing force to the content, mixes the content with air, and ejects the content in a foam form from the outlet.

Here, examples of the anionic surfactant include an alkyl sulfate, an alkyl ether sulfate, an alkylbenzene sulfonate, an N-acylamino acid salt, an N-acylmethyltaurine salt, and an alkyl ether acetate. The blending amount of the anionic surfactant needs to be 0.1% or more of the whole composition, preferably 0.1 to 3%, more preferably 0.2 to 2%.
If the amount is less than 0.1%, the foaming property is deteriorated, and the object of the present invention cannot be achieved. If it is more than 3%, the feeling of use such as irritation of the oral mucosa may be reduced.

Nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, sucrose fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene poly Oxypropylene copolymers, fatty acid diethanolamides and the like can be mentioned. The amount of these nonionic surfactants is preferably 0.1 to 5%, particularly 0.5 to 4% of the whole composition. If it is less than 0.1%, the dissolution of the oil-soluble component may not be sufficient, and if it is more than 5%, the feeling of use such as base taste may be poor.

In the present invention, as the amphoteric surfactant, one or more of an imidazolinium betaine type, an acyl / dialkylethylenediamine derivative and an N-alkylamino acid derivative are used.

In this case, imidazolinium betaine-type amphoteric surfactants include undecyl hydroxyethyl imidazolinium betaine sodium and undecyl-N-hydroxyethyl-N-carboxymethyl imidazolinium betaine. And 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine are preferably used. Further, as the acyl / dialkylethylenediamine derivative, the following formulas (1) to (5) are preferable, and as the N-alkylamino acid derivative, the following formulas (6) to (8) are preferable.

[0012]

Embedded image

[0013]

Embedded image (In the above formula, R represents an alkyl group having 8 to 22 carbon atoms,
X represents an alkali metal. )

The amount of the amphoteric surfactant is 0.001.
To 5%, more preferably 0.01 to 3%. 0.0
If it is less than 01%, the surface tension is not sufficiently reduced, and if it is more than 5%, there may be a problem in use feeling and stability.

In the present invention, an alkylammonium salt, an alkylbenzylammonium salt, an amino acid-based surfactant and the like which are cationic surfactants are added in addition to the surfactant within a range not to impair the effects of the present invention. You can also.

The foamy oral composition of the present invention can contain a binder, a thickener, a medicinal ingredient and the like in addition to the above-mentioned surfactant, but does not contain an abrasive.

Examples of the thickener include polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol and butylene glycol. The compounding amount is preferably 0 to 25%, particularly preferably 0 to 15% of the whole composition. If it is more than 25%, a feeling of warmth, bitterness, stickiness, etc. may be caused to deteriorate the feeling of use.

Examples of the binder include hydroxyethylcellulose, polyvinyl alcohol, sodium carboxymethylcellulose, xanthan gum, carrageenan, gelatin, polyvinylpyrrolidone, methylcellulose, polyacrylate, alginate, carboxyvinyl polymer, locust bean gum, guar gum, Gum arabic and the like. The amount is 0% of the total composition.
２2%, particularly preferably 0-1%. If it is more than 2%, the viscosity increases and the extrusion from the container becomes worse, and the foam does not form a lump. In addition, it tends to be sticky at the time of use and the feeling of use is deteriorated.

The amount of the thickener and the binder is not 0% at the same time, and the foam formed immediately breaks if neither the thickener nor the binder is added. I will. Here, when only the thickener is added, the lower limit of the amount is 3%. When only the binder is added, the lower limit of the amount is 0.1%. When using both, the lower limit of the thickener is 1
%, And the lower limit of the binder is 0.05%.

Further, as a medicinal component, fluorides (sodium fluoride, sodium monofluorophosphate, stannous fluoride, etc.), enzyme agents (dextranase, mutanase, etc.), anti-inflammatory agents (dipotassium glycyrrhizinate, Sodium azulene sulfonate, allantoin, glycyrrhetinic acid, tranexamic acid), fungicides (triclosan, cetylpyridinium chloride, chlorhexidine salts, benzethonium chloride, benzalkonium chloride, biosol, thymol, etc.), deodorant components (sodium copper chlorophyllin,
Copper gluconate) and vitamin E. The compounding amount can be an effective amount.

As the fragrance and other components, those known in the oral composition can be used.

The oral composition of the present invention is prepared in a liquid form by using the above-mentioned components. In this case, the surface tension of the liquid oral composition is 35 dyn / cm or less. If the surface tension exceeds 35 dyn / cm, the permeability is poor and the object of the present invention cannot be achieved. The surface tension is a value measured by the Wilhelmy method.

In the present invention, a non-aerosol type non-gas non-aqueous liquid composition is prepared by mixing the above-mentioned liquid oral composition with the air by applying a pressing force to the contents and jetting the contents in the form of a foam from the jet port. It is filled in a pressure vessel and made into a foam when used.

Here, as the container, a known squeeze type or dispenser type container can be used. For example, Japanese Utility Model Publication No. 7-6108 and Japanese Utility Model Application Laid-open No. 7-825.
No. 1, Japanese Utility Model Laid-Open No. 4-102666, and the like, and specifically, various commercially available products can be used.

[0025]

EFFECTS OF THE INVENTION The foamy oral composition of the present invention has the following advantages. The dispersibility and permeability of the preparation are high, and the preparation penetrates to every corner and in detail in the oral cavity, so that it is possible to efficiently prevent oral diseases. By making the liquid dosage form foamy at the time of use, it can be easily put on a toothbrush and used, and the feeling of use is good due to the lubricating action of the foam. Since an appropriate amount of foam with good shape retention lasts, it is easy to brush for a long time. Since a non-gas normal pressure container can be used,
There are no safety and environmental problems at the time of disposal.

[0026]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Examples 1 and 2 and Comparative Examples 1 to 3 Liquid oral compositions shown in Table 1 were prepared, and the surface tension at 25 ° C. was measured by the Wilhelmy method. Next, these liquid oral compositions were used as non-gas normal pressure containers as described in Japanese Utility Model Publication No. 6-475.
The container was filled in the container described in JP-B-77, and the composition for oral cavity was jetted in a foam. The properties of the foam at this time were visually evaluated according to the following criteria. The results are also shown in Table 1. ：: Foam is uniform and good △: Foam is non-uniform X: Foam is very non-uniform

[0028]

[Table 1]

Further, the compositions of Example 1 and Comparative Example 2 and purified water were placed in a beaker, coated with saliva thinly, and dried filter paper (10 × 10 mm, 5A) was gently applied to the surface of each solution. And the time until the filter paper sank was measured. The results of five repetitions were averaged, and the measured value of purified water was taken as 100 to compare with each composition. Since it is considered that the higher the permeability is, the more it will sink in a short time, it was used as an index of permeability.
Table 2 shows the results.

[0030]

[Table 2]

From the results in Table 2, it can be seen that, compared to purified water,
Although the permeability is improved in both Comparative Examples, anionic surfactants,
It was found that by adding an amphoteric surfactant to the nonionic surfactant, the permeability was further improved.

[Examples 3 to 13]

[0033]

[Table 3]

[0034]

[Table 4]

Claims (2)

[Claims] 1. The method according to claim 1, wherein the anionic surfactant is used in an amount of 0.1%.
1% by weight or more, a nonionic surfactant, and an imidazolinium betaine-type amphoteric surfactant as an amphoteric surfactant;
Applying a pressing force to the contents of an oral composition containing one or more of an acyl / dialkylethylenediamine derivative and an N-alkylamino acid derivative and containing no abrasive having a surface tension of 35 dyn / cm or less. A non-aerosol type non-gas atmospheric pressure container which mixes the content with air and spouts out of the spout from the spout. 2. The composition according to claim 1, further comprising a thickener and / or a binder.