JP4892951B2 - Toothpaste composition - Google Patents

Description

  The present invention relates to a toothpaste composition that is excellent in foaming during use and persistence of foam and that provides a smooth feeling on the tooth surface after use.

  Conventionally, in this technical field, cationized polymers have been studied in combination with medicinal ingredients such as fluorine compounds and antiplasmin agents to improve oral retention and mucosal absorbability of those medicinal ingredients (Patent Documents 1 to 3). 4: JP-A-2004-83543, JP-A-2002-205929, JP-A-2001-342123, JP-A-2001-226244).

  Furthermore, studies have been made on a toothpaste composition excellent in storage stability such as prevention of liquid separation using a cationized polymer or excellent in foaming during use (Patent Documents 5 and 6: Japanese Patent Application Laid-Open No. 2002-187829, JP, 6-183939, A).

  However, in recent years, in order to surely implement plaque control by brushing proposed from the viewpoint of preventive dentistry, not only good foaming during use but also persistence of foam is strongly demanded.

  Furthermore, it is important to maintain the willingness to do brushing for continuous plaque control, so that the tooth surface feels smooth after use. It is considered that it is necessary to improve motivation during brushing.

  As described above, although the usefulness of the cationized polymer in the oral cavity in the toothpaste composition is clear, a means for improving the persistence of foam and the smoothness of the tooth surface after use has been found. Not.

JP 2004-83543 A JP 2002-205929 A JP 2001-342123 A JP 2001-226244 A JP 2002-187829 A JP-A-6-183939

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a toothpaste composition that is excellent in foaming during use, has excellent foam persistence, and provides a smooth feeling on the tooth surface after use. .

As a result of intensive studies to achieve the above object, the present inventors have (A) hydroxyethylcellulose dimethyl diallylammonium salt, (B) sodium lauryl sulfate, (C) alkyl group having 12 to 18 carbon atoms, average ethylene oxide. A toothpaste composition in which a polyoxyethylene alkyl ether having 3 to 8 moles, (D) a polyoxyethylene hydrogenated castor oil having 10 to 30 moles of average ethylene oxide, and (E) sodium alginate is appropriately blended is in use. It was found that the foaming was excellent and the foam persistence was excellent, and a smooth feeling of the tooth surface was obtained after use, and the present invention was made.
Therefore, the present invention provides (A) hydroxyethylcellulose dimethyl diallylammonium salt in an amount of 0.01 to 2% by mass,
(B) 0.1-2% by mass of sodium lauryl sulfate,
(C) 0.5 to 3% by mass of a polyoxyethylene alkyl ether having 12 to 18 carbon atoms of an alkyl group and an average ethylene oxide mole number of 3 to 8,
(D) 0.5 to 3% by mass of polyoxyethylene hydrogenated castor oil having an average ethylene oxide mole number of 10 to 30
Compounded and
(E) 0.1-2 mass% of sodium alginate
A toothpaste composition characterized by being formulated is provided.

  ADVANTAGE OF THE INVENTION According to this invention, the toothpaste composition which is excellent in the foaming in use and excellent in the persistence of foam, and can obtain the smooth feeling of a tooth surface after use can be provided.

  Hereinafter, the present invention will be described in more detail. The toothpaste composition of the present invention comprises (A) hydroxyethyl cellulose dimethyl diallyl ammonium salt, (B) sodium lauryl sulfate, (C) an alkyl group having 12 to 18 carbon atoms, average Polyoxyethylene alkyl ether having 3 to 8 moles of ethylene oxide, (D) polyoxyethylene hydrogenated castor oil having 10 to 30 moles of average ethylene oxide, and (E) sodium alginate.

  The (A) component hydroxyethylcellulose dimethyldiallylammonium salt used here is a cationic polymer obtained by graft polymerization of dimethyldiallylammonium salt to hydroxyethylcellulose. The counter ion is a halide ion such as a chloride ion, methosulphate ion, or the like.

  The viscosity of a 2% by mass aqueous solution of hydroxyethylcellulose dimethyl diallylammonium salt of the present invention is 30 mPa · s to 3,000 mPa · s (BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute), In particular, 35 mPa · s to 350 mPa · s (BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute) is preferable. The nitrogen content is preferably 0.1 to 3% by mass, particularly 0.5 to 2.5% by mass. The weight average molecular weight of the hydroxyethyl cellulose dimethyl diallylammonium salt of the present invention is not particularly limited, but is preferably a weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance, preferably 250,000 to 1,500. , 000.

  As such hydroxyethyl cellulose dimethyl diallylammonium salt, Cellcoat L-200 (2 mass% viscosity: 35 mPa · s to 350 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 rotations, 21 ° C., measurement time 1 minute, weight average molecular weight by gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance: 250,000-350,000, cell coat H-100 (2 mass) % Viscosity: 500 mPa · s to 2,750 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute, gel permeation chromatograph (GPC) using polyethylene glycol as a standard substance ) Weight average by method Molecular weight: 1,300,000～1,500,000), and the like. In these, the counter ion is a chloride ion. Among these, Cellcoat L-200 (2 mass% viscosity: 35 mPa · s to 350 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 rotations, 21 ° C., measurement time 1 minute, weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance: 250,000 to 350,000) is preferable.

The blending amount of the hydroxyethyl cellulose dimethyl diallylammonium salt is usually 0.01 to 2% by mass of the whole toothpaste composition, more preferably from the viewpoint of foam persistence, smoothness of the tooth surface and good foaming . It is 01-1 mass%, Most preferably, it is 0.01-0.5 mass%. Can not be obtained sustained slippery feel and foam sufficient tooth surface is less than 0.005 mass%, Ru poor goodness of foaming exceeds 2 mass%. When the blending amount is 0.005 to 2% by mass, the effect excellent in the persistence of the foam, the smoothness of the tooth surface and the good foaming is exhibited.

Next, the blending amount of sodium lauryl sulfate as the component (B) in the present invention is preferably 0.1 to 2 % by mass of the whole toothpaste composition, from the viewpoint of good foaming and a smooth feeling on the tooth surface. Preferably it is 0.5-2 mass%. Is less than 0.1 wt% can not be obtained good enough foaming, greater than 5% by mass slippery have such feeling is obtained of the tooth surface.

  As the polyoxyethylene alkyl ether of component (C) in the present invention, those having an average added mole number of ethylene oxide of 3 to 8 from the viewpoint of good foaming, a smooth feeling on the tooth surface and the sustainability of the foam are used. Preferably 3-5. When the number of added moles of ethylene oxide is less than 3, the foaming is inferior, and when it exceeds 8, the smoothness of the tooth surface may not be obtained.

  Moreover, as a carbon chain of the alkyl group of polyoxyethylene alkyl ether, the thing of 12-18 carbon atoms can be used from the point of the sustainability of a bubble, and the smooth feeling of a tooth surface, Preferably it is 16-18. Is. When the number of carbon atoms is less than 12, the sustainability of the foam may be inferior, and when the number of carbon atoms exceeds 18, the smoothness of the tooth surface may not be obtained.

  Among these, from the viewpoint of good foaming, a smooth feeling on the tooth surface, and the sustainability of the foam, those having an ethylene oxide average added mole number of 5 and an alkyl chain having a carbon chain length of 16 to 18 are particularly preferable.

  A commercial item can be used as such a polyoxyethylene alkyl ether. As commercial products, for example, in the product of Nippon Emulsion Co., Ltd., the alkyl part is cetyl ether, Emarex 103, Emarex 105, Emarex 107, the alkyl part is stearyl ether, Emarex 603, Emarex 605, Emarex 606, Emarex 608 and the like.

The amount of the polyoxyethylene alkyl ether, a smooth-sensitive point of good and tooth surfaces of the foaming is 0.5 to 3% by weight of the total toothpaste composition, particularly preferably from 0.8 to 2 wt% It is. Amount is can not be obtained good enough foaming is less than 0.2 wt%, Ru slippery feel is inferior tooth surface exceeds 5 mass%.

  In addition, the polyoxyethylene hydrogenated castor oil of component (D) in the present invention is one having an average added mole number of ethylene oxide of 10 to 30, from the viewpoint of good foaming and a smooth feeling on the tooth surface. Is preferred. When the average added mole number of ethylene oxide is less than 10, sufficient foaming cannot be obtained, and when it exceeds 30, the smoothness of the tooth surface may not be obtained. As such polyoxyethylene hydrogenated castor oil, for example, HCO-10, HCO-20, HCO-30 from Nikko Chemicals Co., Ltd., HC-10, HC-20, HC-30 from Nippon Emulsion Co., Ltd., Aoki Yushi Kogyo Co., Ltd. The company's BLAUNON RCW-20 (polyoxyethylene 20 mol) and the like.

The amount of the polyoxyethylene hydrogenated castor oil, from smooth-sensitive point of good and tooth surfaces of the foaming is 0.5 to 3% by weight of the total toothpaste composition, particularly preferably from 0.8 to 2 weight %. Amount is can not be obtained good enough foaming is less than 0.2 wt%, Ru slippery feel is inferior tooth surface exceeds 5 mass%.

  In the present invention, sodium alginate is blended as the component (E). Alginic acid is a polysaccharide extracted from brown algae typified by kombu and wakame, and is a linear polysaccharide composed of two uronic acids, D-mannuronic acid and L-guluronic acid. The viscosity of such a 1% by mass aqueous solution of sodium alginate is preferably 20 mPa · s to 1,100 mPa · s (BM type Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute). More preferably, it is 80 mPa · s to 400 mPa · s (BM type Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute).

  Examples of such sodium alginate include Kimika Argin I series manufactured by Kimika Corporation. Particularly preferred is Kimika Argin I-1 (viscosity of 1% by weight aqueous solution: 80 mPa · s to 200 mPa · s, BM Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measuring time 1 minute), Kimika Argin I— 2 (viscosity of 1% by mass aqueous solution: 250 mPa · s to 350 mPa · s, BM type Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute), Kimika Argin I-3 (1% by mass aqueous solution) Viscosity: 300 mPa · s to 400 mPa · s, BM Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute). Among these, Kimika Argin I-2 (viscosity of 1% by weight aqueous solution: 250 mPa · s to 350 mPa · s, BM Brookfield viscometer, rotor No. 2, 20 rotations from the viewpoint of foam persistence and good foaming. , 20 ° C., measurement time 1 minute).

The amount of the sodium alginate in terms of sustainability and foaming good foam, is 0.1 to 2% by weight of the total toothpaste composition, more preferably 0.2 to 2 mass%, particularly preferably 0 .2 to 1.3% by mass. When the amount is less than 0.1 wt% Ri inferior in persistence of foam, more than 3 wt%, the sufficient good effervescence not be obtained.

The toothpaste composition of the present invention can contain other additives as optional components in addition to the above essential components.
In the case of toothpaste, for example, abrasives, binders other than those described above, surfactants other than those described above, wetting agents, fragrances, sweeteners, preservatives, various active ingredients, colorants, and the like can be blended. And can be mixed.

  As abrasives, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, Alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, quaternary calcium phosphate, synthetic resin-based abrasive and the like.

  The blending amount of these abrasives is preferably 2 to 50% by mass, particularly 10 to 40% by mass, based on the whole toothpaste composition.

  Examples of the binder include cellulose derivatives such as sodium carboxymethyl cellulose and hydroxyethyl cellulose, carrageenan, guar gum, montmorillonite, gelatin, sodium polyacrylate, polyvinyl alcohol, polyvinyl pyrrolidone, tragacanth gum, karaya gum, bee gum, xanthan gum and the like.

  The compounding amount of these binders may be a normal amount within a range not impeding the effects of the present invention, but is 0.1 to 2% by mass, particularly 0.3 to 1% by mass of the whole toothpaste composition. Is preferred.

  As surfactants other than the above components (B), (C), and (D), anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be blended. Examples of the anionic surfactant include sodium alkyl sulfate other than sodium lauryl sulfate such as sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut Fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Etc. Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Examples thereof include polyhydric alcohol fatty acid esters such as fatty acid esters, ether type surfactants such as polyoxyethylene polyoxypropylene copolymers and polyoxyethylene alkylphenyl ethers, and fatty acid alkanolamides such as lauric acid diethanolamide. Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.

  The compounding amount of these surfactants is 0 to 1% by mass of the whole toothpaste composition, and when it is blended, it is 0.1 to 1% by mass, particularly 0.1 to 0.5% by mass. preferable.

  Examples of the wetting agent include sorbit, glycerin, propylene glycol, xylit, maltite, lactit and the like, and sorbit and xylit are particularly preferable.

  The blending amount of these wetting agents is preferably 5 to 50% by mass, particularly 20 to 45% by mass, based on the entire composition.

  Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, Powdered fragrance etc.) and menthol Carvone, anethole, cineol, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentan 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as thioacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above.

  Various active ingredients include sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate and other water-soluble phosphate compounds such as orthophosphoric acid potassium salt and sodium salt. , Glucanases such as dextranase and mutanase, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, α-bisabolol, isopropyl Copper compounds such as methylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate, aluminum lactate, strontium chloride, potassium nitrate , Berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate , Extract of soft sugar beet extract, buckwheat extract, clove, rosemary, hornon, safflower and the like.

  In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, titanium oxide, and the like can be blended in normal amounts.

  The material in particular of the container which accommodates the toothpaste composition of this invention is not restrict | limited, Usually, the container used for a composition for oral cavity can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

Toothpaste compositions having the compositions shown in Tables 1 and 2 below were prepared by the following production method.
(Production method)
A phase A in which water-soluble components (sodium fluoride, sodium saccharin, xylit, disodium hydrogen phosphate, sorbite liquid (70%), polyethylene glycol # 4000, DL-alanine) are mixed and dissolved in purified water at room temperature is prepared.
A phase B is prepared by dispersing hydroxyethylcellulose dimethyldiallylammonium chloride, carrageenan, sodium alginate, sodium polyacrylate, and benzalkonium chloride in propylene glycol at room temperature.
The B phase is added and mixed into the A phase under stirring, and further, silicic anhydride, a nonionic surfactant heated and melted at 70 ° C., and a 15% by weight aqueous gelatin solution are added and mixed to prepare the C phase.
A 1.5 L kneader (manufactured by Ishiyama Kogyo Co., Ltd.) is used in the C phase which has been returned to room temperature, with fragrances, abrasives and other components (dextranase, titanium oxide, sodium lauryl sulfate, sodium lauroyl sarcosine, aluminum oxide). The mixture was mixed at normal temperature and defoamed under reduced pressure (down to 4 kPa) to obtain 1.2 kg of a toothpaste composition.

  For the toothpaste compositions shown in Tables 1 and 2, 10 subjects took 1 g of the toothpaste composition in a toothbrush (Lion Corporation, Dentist System Marion Ibrush Regular) and used it after brushing for 3 minutes. About the good foaming of foam, the persistence of foam, and the smooth feeling of the tooth surface after use, the sensory test by relative evaluation was done by the following references | standards, and the average value was calculated | required.

Good foaming during use (score)
3 points: The amount of foaming immediately after use is larger than that of Comparative Example 9 2 points: The amount of foaming immediately after use is slightly larger than that of Comparative Example 9 1.5 points: Compared with Comparative Example 9 immediately after use Foaming amount is equivalent 1 point: Slightly less foaming amount immediately after use than Comparative Example 9 0 point: Foaming amount immediately after use is less than Comparative Example 9 (evaluation criteria for good foaming during use)
◎: Foaming average point in use exceeds 2.0 to 3.0 points ○: Foaming average point in use exceeds 1.5 points to 2.0 points △: Foaming average point in use 1.0 point to 1.5 point ×: Foaming average point in use is 0 point to less than 1.0 point

Sustainability of foam (grade)
3 points: foaming amount after brushing for 3 minutes is larger than that in Comparative Example 8 2 points: foaming amount after brushing for 3 minutes is slightly higher than Comparative Example 8 1.5 points: 3 minutes compared with Comparative Example 8 Foaming amount after brushing is equal 1 point: Foaming amount after brushing for 3 minutes is slightly smaller than Comparative Example 8 0 point: Foaming amount after brushing for 3 minutes is smaller than Comparative Example 8 (Evaluation of foam durability) Standard)
A: The average point of sustainability of the foam is more than 2.0 to 3.0 points. ○: The average point of sustainability of the foam is more than 1.5 points to 2.0 points. Points to 1.5 points ×: The average persistence point of bubbles is 0 points to less than 1.0 points

Smoothness of the tooth surface after use (score)
3 points: The tooth surface after brushing is smoother than Comparative Example 7. 2 points: The tooth surface after brushing is slightly smooth compared to Comparative Example 1.5. 1.5 points: Brushing compared to Comparative Example 7 The degree to which the subsequent tooth surface is smooth 1 point: The degree to which the tooth surface after brushing is slightly lower than that in Comparative Example 7 0 point: The degree to which the tooth surface after brushing is smooth compared to Comparative Example 7 ( Evaluation criteria for smoothness of tooth surface after use)
◎: The smoothness average point of the tooth surface after use exceeds 2.0 to 3.0 points ○: The average smooth point of the tooth surface after use exceeds 1.5 points to 2.0 points △: After use The smoothness average point of the tooth surface is 1.0 point to 1.5 points. X: The smooth average point of the tooth surface after use is 0 point to less than 1.0 point.

  The results are shown below. In addition, the numerical value showing the compounding quantity in Tables 1 and 2 is mass%.

（Ａ）ヒドロキシエチルセルロースジメチルアリルアンモニウムクロリドは日本エヌエスシー株式会社製のセルコートＬ−２００を使用（２質量％水溶液粘度：１３２ｍＰａ・ｓ、ＢＨ型ブルックフィールド粘度計、ローターＮｏ．２、２０回転、２１℃、測定時間１分）
（Ｂ）ラウリル硫酸ナトリウムは東邦化学工業株式会社製のラウリル硫酸ナトリウムを使用
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数５）は日本エマルジョン株式会社製のエマレックス６０５を使用
（Ｃ）ポリオキシエチレンラウリルエーテル（エチレンオキサイド平均付加モル数５）は日本エマルジョン株式会社製のエマレックス７０５を使用
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数３）は日本エマルジョン株式会社製のエマレックス６０３を使用
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数８）は日本エマルジョン株式会社製のエマレックス６０８を使用
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数２０）は日本エマルジョン株式会社製のエマレックスＨＣ−２０を使用
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数１０）は日本エマルジョン株式会社製のエマレックスＨＣ−１０を使用
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数３０）は日本エマルジョン株式会社製のエマレックスＨＣ−３０を使用
（Ｅ）アルギン酸ナトリウムはキミカ株式会社製のキミカアルギンＩ−２を使用（１質量％水溶液粘度：３００ｍＰａ・ｓ、ＢＭ型ブルックフィールド粘度計、ローターＮｏ．２、６０回転、２０℃、測定時間１分）

(A) Hydroxyethyl cellulose dimethylallyl ammonium chloride uses Cell Coat L-200 manufactured by Nippon SC Co., Ltd. (2% by weight aqueous solution viscosity: 132 mPa · s, BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ℃, measuring time 1 minute)
(B) Sodium lauryl sulfate used by Toho Chemical Co., Ltd. is used as sodium lauryl sulfate (C) Polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 5) is used by Emulex 605 manufactured by Nippon Emulsion Co., Ltd. (C ) Polyoxyethylene lauryl ether (average number of added moles of ethylene oxide 5) uses Emulex 705 manufactured by Nippon Emulsion Co., Ltd. (C) Polyoxyethylene stearyl ether (average number of added moles of ethylene oxide 3) manufactured by Japan Emulsion Co., Ltd. (C) Polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 8) used Emalex 608 manufactured by Japan Emulsion Co., Ltd. (D) Polyoxyethylene hydrogenated castor oil (ethylene oxide) (E) The average added mole number of id is 20) using Emalex HC-20 manufactured by Nippon Emulsion Co., Ltd. (D) Polyoxyethylene hydrogenated castor oil (average added mole number of ethylene oxide 10) is Emalex HC- manufactured by Nippon Emulsion Co., Ltd. 10 (D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 30) used Emulex HC-30 manufactured by Nippon Emulsion Co., Ltd. (E) Sodium alginate was Kimika Algin I-2 manufactured by Kimika Co., Ltd. (1% by weight aqueous solution viscosity: 300 mPa · s, BM Brookfield viscometer, rotor No. 2, 60 revolutions, 20 ° C., measurement time 1 minute)

（Ａ）ヒドロキシエチルセルロースジメチルアリルアンモニウムクロリドは日本エヌエスシー株式会社製のセルコートＬ−２００を使用（２質量％水溶液粘度：１３２ｍＰａ・ｓ、ＢＨ型ブルックフィールド粘度計、ローターＮｏ．２、２０回転、２１℃、測定時間１分）
（Ｂ）ラウリル硫酸ナトリウムは東邦化学工業株式会社製のラウリル硫酸ナトリウムを使用
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数５）は日本エマルジョン株式会社製のエマレックス６０５を使用
（Ｃ）比較品：ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数２）は日本エマルジョン株式会社製のエマレックス６０２を使用
（Ｃ）比較品：ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数１１）は日本エマルジョン株式会社製のエマレックス６１１を使用
（Ｃ）比較品：ポリオキシエチレンオレイルエーテル（エチレンオキサイド平均付加モル数５）は日本エマルジョン株式会社製のエマレックス５０５Ｈを使用
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数２０）は日本エマルジョン株式会社製のエマレックスＨＣ−２０を使用
（Ｄ）比較品：ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数５）は日本エマルジョン株式会社製のエマレックスＨＣ−５を使用
（Ｄ）比較品：ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数４０）は日本エマルジョン株式会社製のエマレックスＨＣ−４０を使用
（Ｅ）アルギン酸ナトリウムはキミカ株式会社製のキミカアルギンＩ−２を使用（１質量％水溶液の粘度：３００ｍＰａ・ｓ、ＢＭ型ブルックフィールド粘度計、ローターＮｏ．２、６０回転、２０℃、測定時間１分）

(A) Hydroxyethyl cellulose dimethylallyl ammonium chloride uses Cell Coat L-200 manufactured by Nippon SC Co., Ltd. (2% by weight aqueous solution viscosity: 132 mPa · s, BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ℃, measuring time 1 minute)
(B) Sodium lauryl sulfate used by Toho Chemical Co., Ltd. is used as sodium lauryl sulfate (C) Polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 5) is used by Emulex 605 manufactured by Nippon Emulsion Co., Ltd. (C ) Comparative product: Polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 2) uses Emulex 602 manufactured by Japan Emulsion Co., Ltd. (C) Comparative product: polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 11) Uses Emulex 611 manufactured by Nippon Emulsion Co., Ltd. (C) Comparative product: Polyoxyethylene oleyl ether (average number of added moles of ethylene oxide 5) uses Emalex 505H manufactured by Nihon Emulsion Co., Ltd. (D) Polyoxyethylene Hardened castor oil (ethylene oxide average added mole number 20) uses Emulex HC-20 manufactured by Nippon Emulsion Co., Ltd. (D) Comparative product: Polyoxyethylene hydrogenated castor oil (ethylene oxide average added mole number 5) is Japanese emulsion Use Emalex HC-5 manufactured by Co., Ltd. (D) Comparative product: Polyoxyethylene hydrogenated castor oil (Ethylene oxide average added mole number 40) uses Emalex HC-40 manufactured by Japan Emulsion Co., Ltd. (E) Alginic acid Sodium used Kimika Argin I-2 manufactured by Kimika Co., Ltd. (Viscosity of 1% by weight aqueous solution: 300 mPa · s, BM Brookfield viscometer, rotor No. 2, 60 revolutions, 20 ° C., measurement time 1 minute)

  From the results of Tables 1 and 2, in Examples 1 to 14, hydroxyethyl cellulose dimethyl diallyl ammonium salt, sodium lauryl sulfate, alkyl group having 12 to 18 carbon atoms, average ethylene oxide mole number of 3 to 8 polyoxyethylene alkyl ether, average A toothpaste composition containing a specific amount of polyoxyethylene hydrogenated castor oil having 10 to 30 moles of ethylene oxide and sodium alginate has good foaming during use, persistence of foam, and a smooth feeling on the tooth surface after use. Was also good. On the other hand, in Comparative Examples 1 to 10, sufficient effects are not exhibited in any of the good foaming in use, the persistence of the foam, and the smooth feeling of the tooth surface after use.

Claims (3)

(A) 0.01-2 mass% of hydroxyethylcellulose dimethyl diallylammonium salt,
(B) 0.1-2% by mass of sodium lauryl sulfate,
(C) 0.5 to 3% by mass of a polyoxyethylene alkyl ether having 12 to 18 carbon atoms of an alkyl group and an average ethylene oxide mole number of 3 to 8,
(D) 0.5 to 3% by mass of polyoxyethylene hydrogenated castor oil having an average ethylene oxide mole number of 10 to 30
And (E) 0.1-2% by mass of sodium alginate
A toothpaste composition characterized by being formulated . The component (A) is 0.01 to 0.5% by mass, the component (B) is 0.5 to 2% by mass, and the component (C) is a polyoxyethylene stearyl ether having an average ethylene oxide mole number of 5 to 8. The content is 0.8-3 mass%, the component (D) is a polyoxyethylene hydrogenated castor oil having an average ethylene oxide mole number of 20-30, the content is 0.8-3 mass%, and The toothpaste composition according to claim 1, which comprises 0.2 to 1.3% by mass of component (E). The toothpaste composition according to claim 1 or 2, wherein (E) sodium alginate has a 1 mass% aqueous solution having a viscosity at 20 ° C of 80 to 400 mPa · s.