JP2006182658A - Toothpaste composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a toothpaste composition causing little dripping of liquid from the mouth and having excellent plaque removing power. <P>SOLUTION: The toothpaste composition contains (A) hydroxyethyl cellulose dimethyldiallylammonium salt, (B) sodium laurylsulfate, (C) a polyoxyethylene alkyl ether having a 12-18C alkyl group and an average ethylene oxide molar number of 3-8, (D) a polyoxyethylene hardened castor oil having an average ethylene oxide molar number of 10-30 and (E) silicic acid anhydride. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a toothpaste composition having little dripping from the mouth and excellent plaque removal power.

  Conventionally, in this technical field, cationized polymers have been studied in combination with medicinal ingredients such as fluorine compounds and antiplasmin agents to improve oral retention and mucosal absorbability of those medicinal ingredients (Patent Documents 1 to 3). 4: JP-A-2004-83543, JP-A-2002-205929, JP-A-2001-342123, JP-A-2001-226244).

  Furthermore, studies have been made on a toothpaste composition with improved storage stability such as prevention of liquid separation using a cationized polymer or excellent foamability during use (Patent Documents 5 to 7: JP 2002-187829 A). JP-A-6-183939 and JP-A-60-1116).

  In recent years, an effective means for removing plaque has been strongly demanded for plaque control by brushing proposed from the viewpoint of preventive dentistry. In order to efficiently remove plaque, it is considered that it is effective that the dentifrice has excellent plaque removing power and that the dentifrice works sufficiently without overflowing from the mouth.

  However, although the usefulness of the cationized polymer in the oral cavity in the toothpaste composition is clear, no means for improving the plaque removal effect has been found.

JP 2004-83543 A JP 2002-205929 A JP 2001-342123 A JP 2001-226244 A JP 2002-187829 A JP-A-6-183939 JP-A-60-1116

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a toothpaste composition that is less dripping from the mouth and has excellent plaque removing power.

As a result of intensive studies to achieve the above object, the present inventors have (A) hydroxyethylcellulose dimethyl diallylammonium salt, (B) sodium lauryl sulfate, (C) alkyl group having 12 to 18 carbon atoms, average ethylene oxide. A toothpaste composition containing polyoxyethylene alkyl ether having 3 to 8 moles, (D) polyoxyethylene hydrogenated castor oil having 10 to 30 moles of average ethylene oxide, and (E) silicic anhydride is a liquid from the mouth. It has been found that there are few and excellent plaque removing power can be obtained, and the present invention has been made.
In addition, the dripping from the mouth here is a mixture of dentifrice and saliva.
Therefore, this invention provides the toothpaste composition containing the said (A)-(E) component.

  ADVANTAGE OF THE INVENTION According to this invention, the toothpaste composition with little dripping from a mouth and excellent in plaque removal power can be provided.

  Hereinafter, the present invention will be described in more detail. The toothpaste composition of the present invention comprises (A) hydroxyethyl cellulose dimethyl diallyl ammonium salt, (B) sodium lauryl sulfate, (C) an alkyl group having 12 to 18 carbon atoms, average Polyoxyethylene alkyl ether having 3 to 8 moles of ethylene oxide, (D) polyoxyethylene hydrogenated castor oil having 10 to 30 moles of average ethylene oxide, and (E) silicic anhydride.

  The (A) component hydroxyethylcellulose dimethyldiallylammonium salt used here is a cationic polymer obtained by graft polymerization of dimethyldiallylammonium salt to hydroxyethylcellulose. The counter ion is a halide ion such as a chloride ion, methosulphate ion, or the like.

  The viscosity of a 2% by weight aqueous solution of the hydroxyethylcellulose dimethyldiallylammonium salt of the present invention (BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute) is 30 mPa · s to 3,000 mPa · s, 35 mPa · s to 350 mPa · s is particularly preferable. The nitrogen content is preferably 0.1 to 3% by mass, particularly preferably 0.5 to 2.5% by mass. The weight average molecular weight of the hydroxyethyl cellulose dimethyl diallylammonium salt of the present invention is not particularly limited, but is preferably a weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance, preferably 250,000 to 1,500. , 000.

  As such hydroxyethyl cellulose dimethyl diallylammonium salt, Cellcoat L-200 (2 mass% viscosity: 35 mPa · s to 350 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 rotations, 21 ° C., measurement time 1 minute, weight average molecular weight by gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance: 250,000-350,000, cell coat H-100 (2 mass) % Viscosity: 500 mPa · s to 2,750 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute, gel permeation chromatograph (GPC) using polyethylene glycol as a standard substance ) Weight average by method Molecular weight: 1,300,000～1,500,000), and the like. In these, the counter ion is a chloride ion. Among these, Cellcoat L-200 (2 mass% viscosity: 35 mPa · s to 350 mPa · s, BH Brookfield viscometer, rotor No. 2, 20 from the viewpoint of plaque removing power and dripping from the mouth. Rotation, 21 ° C., measurement time 1 minute, weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance: 250,000 to 350,000) are preferable.

  The blending amount of the hydroxyethyl cellulose dimethyl diallylammonium salt is preferably 0.001 to 2% by mass, more preferably 0.005 to 5% of the whole toothpaste composition, from the viewpoint of plaque removal power and dripping from the mouth. 1% by mass, particularly preferably 0.01 to 0.5% by mass. When the amount is less than 0.001% by mass of the whole toothpaste composition, dripping from the mouth may be inferior, and when it exceeds 2% by mass, sufficient plaque removing power may not be obtained.

  Next, the blending amount of sodium lauryl sulfate as the component (B) in the present invention is preferably 0.1 to 5% by mass of the whole toothpaste composition, from the viewpoint of plaque removal power and dripping from the mouth. More preferably, it is 0.5-3 mass%, Most preferably, it is 0.5-2 mass%. If it is less than 0.1% by mass, sufficient plaque removing power may not be obtained, and if it exceeds 5% by mass, dripping from the mouth may be inferior.

  In the present invention, the average addition mole number of ethylene oxide of the polyoxyethylene alkyl ether of component (C) can be 3 to 8 from the viewpoint of plaque removal power and dripping from the mouth, preferably 3-5. When the number of moles of ethylene oxide added is less than 3, the plaque removing power is inferior, and when it exceeds 8, the dripping from the mouth is inferior.

  In addition, as the carbon chain length of the alkyl chain of polyoxyethylene alkyl ether, those having 12 to 18 carbon atoms can be used from the viewpoint of plaque removing power and dripping from the mouth, and preferably 16 to 18 carbon atoms. belongs to. Those having a carbon number of less than 12 may have inferior plaque removing power, and those having a carbon number of more than 18 may have poor liquid dripping from the mouth.

  Among these, from the viewpoint of plaque removal power and dripping from the mouth, those having an average added mole number of ethylene oxide of 3 to 5 and a carbon chain length of the alkyl chain of 16 to 18 are particularly preferable.

  A commercial item can be used as such a polyoxyethylene alkyl ether. As commercial products, for example, in the product of Nippon Emulsion Co., Ltd., the alkyl part is cetyl ether, Emarex 103, Emarex 105, Emarex 107, the alkyl part is stearyl ether, Emarex 603, Emarex 605, Emarex 606, Emarex 608 and the like.

  The blending amount of the polyoxyethylene alkyl ether is preferably 0.2 to 5% by mass, more preferably 0.5 to 3% by mass, and particularly preferably the whole toothpaste composition, from the viewpoint of dripping from the mouth. It is 0.8-2 mass%. When the blending amount is 0.2 to 5% by mass, an effect excellent in dripping from the mouth is exhibited.

  In addition, the polyoxyethylene hydrogenated castor oil of component (D) in the present invention has an average added mole number of ethylene oxide of 10 to 30 from the viewpoint of plaque removal power and dripping from the mouth, 20 are preferred. When the average added mole number of ethylene oxide is less than 10, sufficient plaque removing power cannot be obtained, and when it exceeds 30, the dripping from the mouth may be inferior. As such polyoxyethylene hydrogenated castor oil, for example, HCO-10, HCO-20, HCO-30 from Nikko Chemicals Co., Ltd., HC-10, HC-20, HC-30 from Nippon Emulsion Co., Ltd., Aoki Yushi Kogyo Co., Ltd. The company's BLAUNON RCW-20 (polyoxyethylene 20 mol) and the like.

  The blending amount of the polyoxyethylene hydrogenated castor oil is preferably 0.2 to 5% by mass, more preferably 0.5 to 3% by mass, particularly preferably the whole toothpaste composition, from the viewpoint of dripping from the mouth. Is 0.8-2 mass%. When the blending amount is 0.2 to 5% by mass, an effect excellent in dripping from the mouth is exhibited.

  Furthermore, the silicic anhydride of the component (E) in the present invention includes a silica gel method or a precipitation method as its production method, specifically, Zeodent (manufactured by Huber), Nip seal (manufactured by Nippon Silica Kogyo Co., Ltd.), Silysia , Silopure (Fuji Silysia), Thixosyl (Rhodia), Toxeal (Tokuyama), Sorbosil (Ineos), Erosyl (Nippon Aerosil), Amorphous silicic acid (Taki Chemical) Manufactured). The blending amount is preferably 5 to 30% by mass, more preferably 10 to 25% by mass, and particularly preferably 15 to 20% by mass from the viewpoint of plaque removal power. When the blending amount is 5 to 30% by mass, an effect excellent in plaque removing power is exhibited.

  Furthermore, in order to improve the plaque removal power, the above-mentioned silicic anhydride is composed of (E1) silicic acid having a 50% average particle size of 100 μm to 700 μm by weight distribution by a sieving method using a JIS standard sieve, and (E2 ) Using a laser diffraction / scattering particle size distribution measuring device (Microtrack particle size distribution measuring device Model 7995-10 manufactured by Nikkiso Co., Ltd.), a sample was put into ion-exchanged water and measured, and the 50% average particle size was 0.1 μm. The silicic acid anhydride having a mass ratio of less than 100 μm is (E1) / (E2) = 0.05 to 0.2, preferably 0.05 to 0.15, particularly preferably 0.07 to 0.13. Those combined in proportion are preferred. When the mass ratio of the (E1) component and the (E2) component is 0.05 to 0.2, an effect excellent in plaque removing power is exhibited.

  The toothpaste composition of the present invention can contain other additives as optional components in addition to the above essential components.

  In the case of toothpaste, for example, abrasives other than those described above, binders, surfactants other than those described above, wetting agents, fragrances, sweeteners, preservatives, various active ingredients, coloring agents, and the like can be blended. And can be mixed.

  As an abrasive, calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, Examples thereof include tricalcium phosphate, hydroxyapatite, quaternary calcium phosphate, and a synthetic resin abrasive.

  The blending amount of the abrasives other than silicic acid anhydride of these components (E) is 0 to 20% by mass of the whole toothpaste composition, and 2 to 20% by mass, especially 5 to 15% by mass when blended. It is preferable that

  Examples of the binder include cellulose derivatives such as sodium carboxymethyl cellulose and hydroxyethyl cellulose, carrageenan, guar gum, alginic acid, montmorillonite, gelatin, sodium polyacrylate, polyvinyl alcohol, polyvinyl pyrrolidone, tragacanth gum, karaya gum, bee gum, xanthan gum and the like.

  The compounding amount of these binders may be a normal amount within a range not impeding the effects of the present invention, but is 0.1 to 2% by mass, particularly 0.3 to 1% by mass of the whole toothpaste composition. Is preferred.

  As surfactants other than the components (B), (C), and (D), an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended. Examples of the anionic surfactant include sodium alkyl sulfate other than sodium lauryl sulfate such as sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut Fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Etc. Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Examples thereof include polyhydric alcohol fatty acid esters such as fatty acid esters, ether type surfactants such as polyoxyethylene polyoxypropylene copolymers and polyoxyethylene alkylphenyl ethers, and fatty acid alkanolamides such as lauric acid diethanolamide. Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.

  The compounding amount of these surfactants is 0 to 1% by mass of the whole toothpaste composition, and when it is blended, it is 0.1 to 1% by mass, particularly 0.1 to 0.5% by mass. preferable.

  Examples of the wetting agent include sorbit, glycerin, propylene glycol, xylit, maltite, lactit and the like, and sorbit and xylit are particularly preferable.

  The blending amount of these wetting agents is preferably 5 to 50% by mass, particularly 20 to 45% by mass, based on the whole toothpaste composition.

  Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, Powdered fragrance etc.) and menthol Carvone, anethole, cineol, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentan 3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as thioacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above.

  Various active ingredients include sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate and other water-soluble phosphate compounds such as orthophosphoric acid potassium salt and sodium salt. , Glucanase such as dextranase and mutanase, allantoin chlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, α-bisabolol, isopropyl Copper compounds such as methylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate, aluminum lactate, strontium chloride, potassium nitrate , Berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate , Extract of soft sugar beet extract, buckwheat extract, clove, rosemary, hornon, safflower and the like.

  In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, titanium dioxide and the like can be blended in usual amounts.

  The material in particular of the container which accommodates the toothpaste composition of this invention is not restrict | limited, Usually, the container used for a composition for oral cavity can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

  In the following examples, the average particle diameter of silicic anhydride of 100 μm to 700 μm refers to the 50% average particle diameter according to the weight distribution by the sieving method using JIS standard sieve, and the average particle diameter of silicic anhydride is 0.1 μm to 100 μm. Below is a 50% average particle size measured by putting a sample into ion-exchanged water using a laser diffraction / scattering particle size distribution measuring device (Microtrack particle size distribution measuring device Model 7995-10 manufactured by Nikkiso Co., Ltd.). .

Toothpaste compositions having the compositions shown in Tables 1 to 3 below were prepared by the following production method.
(Production method)
A phase A is prepared by mixing and dissolving water-soluble components (sodium fluoride, sodium saccharin, xylit, disodium hydrogen phosphate, sorbite solution, polyethylene glycol # 4000, DL-alanine) in purified water at room temperature.
A phase B is prepared by dispersing hydroxyethylcellulose dimethyldiallylammonium chloride, carrageenan, sodium alginate, sodium polyacrylate, and benzalkonium chloride at room temperature in propylene glycol.
A phase B is added to and mixed with the phase A being stirred, and a nonionic surfactant melted by heating at 70 ° C. and a 15% by weight aqueous gelatin solution are added and mixed to prepare a phase C.
In phase C, 1.5 L kneader (manufactured by Ishiyama Kogyo Co., Ltd.) is used for ingredients such as fragrance, silicic anhydride, and other ingredients (dextranase, titanium oxide, sodium lauryl sulfate, sodium lauroyl sarcosine, aluminum oxide) The mixture was mixed at room temperature and defoamed under reduced pressure (down to 4 kPa) to obtain 1.2 kg of a toothpaste composition.

Test of dripping from the mouth About the toothpaste composition shown in Tables 1 to 3 by 10 subjects using a toothpaste composition 1 g and a toothbrush (PC clinical ion standard, hardness: normal) for 3 minutes during brushing For the liquid dripping from the mouth, a sensory test was performed by relative evaluation according to the following criteria to obtain an average value.
(Score)
3 points: No liquid dripping from the mouth during brushing 2 points: Some liquid dripping, but less compared to Comparative Example 5 1 point: Compared with Comparative Example 5, dripping from the mouth during brushing is the same or more ( Evaluation criteria for dripping from the mouth)
◎: Mean dripping from the mouth is 2.0 to 3.0 points ○: Mean dripping from the mouth is 1.5 points to less than 2.0 points ×: Average dripping from the mouth The score is 1.0 or more and less than 1.5

Dental plaque removal test The toothpaste compositions shown in Tables 1 to 3 were tested by the following methods by 10 subjects, and the average value of the plaque removal index was determined.
(1) Stop oral cleaning 48 hours before the test.
(2) Add 3 drops of plaque stain solution (BUTLER GUM RED COTE) to 3.5 mL of ion exchange water and stir, then rinse with 15 mL of ion exchange water to stain plaque adhering to the tooth surface. did.
(3) Photograph the front teeth of the upper and lower jaws.
(4) After brushing for 3 minutes using 1 g of the toothpaste composition shown in Tables 1 to 3 and a toothbrush (PC clinical ion standard, hardness: normal), rinsing was performed twice using 15 mL of ion-exchanged water. .
(5) Add 3 drops of plaque stain solution (BUTLER GUM RED COTE) and stir in 3.5 mL of ion-exchanged water, then rinse with 15 mL of ion-exchanged water to stain plaque adhering to the tooth surface. did.
(6) Photograph the front teeth of the upper and lower jaws.
(7) From the photographs before and after brushing, the untreated anterior teeth are selected one by one from the upper and lower jaws, and using the same tooth before and after brushing, the tooth surface of the lower jaw anterior teeth is divided into 9 as shown in FIG. The number of plaque-attached surfaces was counted, and the plaque removal index was calculated by the following formula.
Plaque removal index = (number of plaque adhesion surfaces before brushing-number of plaque adhesion surfaces after brushing)
(Evaluation criteria for plaque removal power)
◎: Plaque removal index average score of 7 to 9 points ○: Plaque removal index average score of 5 to less than 7 △: Plaque removal index average score of 3 to less than 5 ×: The average plaque removal index score is 0 or more and less than 3

  The results are shown below. In addition, the numerical value showing the compounding quantity in Tables 1-3 is all the mass%.

（Ａ）ヒドロキシエチルセルロースジメチルジアリルアンモニウムクロリド［日本エヌエスシー株式会社製：セルコートＬ−２００（２質量％水溶液粘度（ＢＨ型ブルックフィールド粘度計、ローターＮｏ．２、２０回転、２１℃、測定時間１分）：１３２ｍＰａ・ｓ）］
（Ｂ）ラウリル硫酸ナトリウム［東邦化学株式会社製：ラウリル硫酸ナトリウム］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数５）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６０５］
（Ｃ）ポリオキシエチレンラウリルエーテル（エチレンオキサイド平均付加モル数５）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ７０５］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数３）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６０３］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数８）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６０８］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数２０）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−２０］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数１０）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−１０］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数３０）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−３０］
（Ｅ１）無水ケイ酸［イネオス社製：ソルボシルＢＦＧ５０（平均粒子径（ＪＩＳ標準ふるいを用いたふるい分け法による重量分布による、５０％平均粒子径）：３００μｍ）］
（Ｅ２）無水ケイ酸［多木化学株式会社製：非晶質無水ケイ酸（平均粒子径（日機装株式会社製マイクロトラック粒度分布測定装置Ｍｏｄｅｌ ７９９５−１０を用いて測定した５０％平均粒子径））：１８μｍ）］
アルギン酸ナトリウム［キミカ株式会社製：キミカアルギンＩ−２］

(A) Hydroxyethylcellulose dimethyl diallylammonium chloride [NSC Co., Ltd .: Cellcoat L-200 (2% by weight aqueous solution viscosity (BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute) ): 132 mPa · s)]
(B) Sodium lauryl sulfate [Toho Chemical Co., Ltd .: sodium lauryl sulfate]
(C) Polyoxyethylene stearyl ether (average number of added moles of ethylene oxide 5) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 605]
(C) Polyoxyethylene lauryl ether (average number of added moles of ethylene oxide 5) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 705]
(C) Polyoxyethylene stearyl ether (average number of added moles of ethylene oxide 3) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 603]
(C) Polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 8) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 608]
(D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 20) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-20]
(D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 10) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-10]
(D) Polyoxyethylene hydrogenated castor oil (average number of added moles of ethylene oxide 30) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-30]
(E1) Silicic anhydride [manufactured by Ineos: sorbosyl BFG50 (average particle size (50% average particle size by weight distribution by sieving method using JIS standard sieve): 300 μm)]
(E2) Silicic acid [manufactured by Taki Chemical Co., Ltd .: amorphous silicic acid (average particle size (50% average particle size measured using Nikkiso Co., Ltd. Microtrac particle size distribution measuring device Model 7995-10)] ): 18 μm)]
Sodium alginate [Kimika Co., Ltd .: Kimika Argin I-2]

（Ａ）ヒドロキシエチルセルロースジメチルジアリルアンモニウムクロリド［日本エヌエスシー株式会社製：セルコートＬ−２００（２質量％水溶液粘度（ＢＨ型ブルックフィールド粘度計、ローターＮｏ．２、２０回転、２１℃、測定時間１分）：１３２ｍＰａ・ｓ）］
（Ｂ）ラウリル硫酸ナトリウム［東邦化学株式会社製：ラウリル硫酸ナトリウム］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数５）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６０５］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数２）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６０２（比較品＊１）］
（Ｃ）ポリオキシエチレンステアリルエーテル（エチレンオキサイド平均付加モル数１１）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ６１１（比較品＊２）］
（Ｃ）ポリオキシエチレンオレイルエーテル（エチレンオキサイド平均付加モル数５）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ５０５Ｈ（比較品＊３）］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数２０）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−２０］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数５）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−５（比較品＊４）］
（Ｄ）ポリオキシエチレン硬化ヒマシ油（エチレンオキサイド平均付加モル数４０）［日本エマルジョン株式会社製：ＥＭＡＬＥＸ ＨＣ−４０（比較品＊５）］
（Ｅ１）無水ケイ酸［イネオス社製：ソルボシルＢＦＧ５０（平均粒子径（ＪＩＳ標準ふるいを用いたふるい分け法による重量分布による、５０％平均粒子径）：３００μｍ）］
（Ｅ２）無水ケイ酸［多木化学株式会社製：非晶質無水ケイ酸（平均粒子径（日機装株式会社製マイクロトラック粒度分布測定装置Ｍｏｄｅｌ ７９９５−１０を用いて測定した５０％平均粒子径）：１８μｍ）］
アルギン酸ナトリウム［キミカ株式会社製：キミカアルギンＩ−２］

(A) Hydroxyethylcellulose dimethyl diallylammonium chloride [NSC Co., Ltd .: Cellcoat L-200 (2% by weight aqueous solution viscosity (BH Brookfield viscometer, rotor No. 2, 20 revolutions, 21 ° C., measurement time 1 minute) ): 132 mPa · s)]
(B) Sodium lauryl sulfate [Toho Chemical Co., Ltd .: sodium lauryl sulfate]
(C) Polyoxyethylene stearyl ether (average number of added moles of ethylene oxide 5) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 605]
(C) Polyoxyethylene stearyl ether (ethylene oxide average addition mole number 2) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 602 (comparative product * 1)]
(C) polyoxyethylene stearyl ether (average number of moles of ethylene oxide added 11) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX 611 (comparative product * 2)]
(C) Polyoxyethylene oleyl ether (average addition mole number of ethylene oxide 5) [manufactured by Japan Emulsion Co., Ltd .: EMALEX 505H (comparative product * 3)]
(D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 20) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-20]
(D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 5) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-5 (comparative product * 4)]
(D) Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added 40) [manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-40 (comparative product * 5)]
(E1) Silicic anhydride [manufactured by Ineos: sorbosyl BFG50 (average particle size (50% average particle size by weight distribution by sieving method using JIS standard sieve): 300 μm)]
(E2) Silicic anhydride [manufactured by Taki Chemical Co., Ltd .: amorphous silicic acid (average particle size (50% average particle size measured using Nikkiso Co., Ltd. Microtrac particle size distribution measuring device Model 7995-10)] : 18 μm)]
Sodium alginate [Kimika Co., Ltd .: Kimika Argin I-2]

  From the results of Tables 1 to 3, in Examples 1 to 20, hydroxyethyl cellulose dimethyl diallyl ammonium salt, sodium lauryl sulfate, alkyl group having 12 to 18 carbon atoms, average ethylene oxide mole number of 3 to 8 polyoxyethylene alkyl ether, average The toothpaste compositions containing a specific amount of polyoxyethylene hydrogenated castor oil having 10 to 30 moles of ethylene oxide and silicic anhydride had little dripping from the mouth and good plaque removal power. On the other hand, in Comparative Examples 1 to 10, sufficient effects are not exhibited in any of the points of dripping from the mouth and plaque removing power.

In the plaque removal test, a tooth surface division diagram of the mandibular anterior teeth divided into 9 parts to obtain a plaque removal index is shown.

Claims (2)

(A) hydroxyethylcellulose dimethyl diallylammonium salt,
(B) sodium lauryl sulfate,
(C) a polyoxyethylene alkyl ether having an alkyl group having 12 to 18 carbon atoms and an average ethylene oxide mole number of 3 to 8,
(D) polyoxyethylene hydrogenated castor oil having an average ethylene oxide mole number of 10 to 30,
(E) A toothpaste composition comprising silicic anhydride.   As anhydrous silicic acid (E), (E1) (E1) / (E2) by weight ratio of (E1) silicic anhydride having an average particle diameter of 100 μm to 700 μm and (E2) silicic anhydride having an average particle diameter of 0.1 μm or more and less than 100 μm The toothpaste composition according to claim 1, which is used in combination at a ratio of 0.05 to 0.2.

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