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WO2005092277A1 - Oral composition - Google Patents

Oral composition

Info

Publication number
WO2005092277A1
WO2005092277A1 PCT/EP2005/002879 EP2005002879W WO2005092277A1 WO 2005092277 A1 WO2005092277 A1 WO 2005092277A1 EP 2005002879 W EP2005002879 W EP 2005002879W WO 2005092277 A1 WO2005092277 A1 WO 2005092277A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
composition
oral
betaine
agents
surfactant
Prior art date
Application number
PCT/EP2005/002879
Other languages
French (fr)
Inventor
Alison Katharine Green
Ilaria Faravelli
Original Assignee
Unilever N.V.
Unilever Plc
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

An oral composition comprising zinc citrate, a betaine derivative and an anionic surfactant, characterised in that the composition comprises the betaine derivative and the anionic surfactant in a weight ratio of from 0.5:1 to 2:1.

Description

ORAL COMPOSITION

The present invention relates to an oral composition according to the preamble of claim 1.

The object of the present invention is to provide an oral composition which improves the delivery of sparingly soluble zinc citrate from an oral composition comprising an anionic surfactant.

WO02/026203 (Henkel) discloses an oral composition comprising cocoacylamidopropyl betaine and sodium lauryl sulphate. The composition also comprises zinc sulphate, a water soluble zinc salt.

Accordingly, the present invention provides an oral composition according to claim 1.

Preferably, the composition comprises the betaine derivative and the anionic surfactant in a weight ratio of from 0.95:1 to 1.05:1.

Preferably, the oral care composition according to the invention comprises from 0.001 to 5% by weight zinc citrate, more preferably from 0.5 to 3.0% by weight.

Suitable anionic surfactants are, for example, sodium alkyl sulfates containing 12 to 18 carbon atoms in the alkyl group. Other suitable anionic surfactants are alkali metal salts, preferably sodium salts of alkyl polyglycol ether sulfate containing 12 to 16 carbon atoms in the linear alkyl group and 2 to 6 glycol ether groups in the molecule, of linear alkane (C 12-18) sulfonate, • of sulfosuccinic acid onoalkyl (C 12-18 ) esters, of .suJLfated fatty acid onoglycerides, sulfated fatty acicTalkanolamides, sulfoacetic acid alkyl (C 12-16' ).* esters, acyl sarcosines, acyl taurides and acyl isothionates containing 8 to 18 carbon atoms in the acyl group.

Suitable betaine surfactants include cocoalkyl betaine or cocoamidopropyl betaine.

Preferably the antimicrobial agent is present in an amount of from 0.01 to 5% by weight of the composition, more preferably from 0.5 to 3% by weight..

The oral composition according to the invention comprise further ingredients which are common in the art, such as:

antimicrobial agents, e.g. Triclosan, chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro-6-bromophenol) , and the alkyl parabens such as n-octyl paraben and analogues thereof;

anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;

plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates;

vitamins such as Vitamins A, C and E;

plant extracts;

desensitising agents, e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;

anti-calculus agents, e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc.;

biomolecules, e.g. bacteriocins, antibodies, enzymes, etc.; flavours, e.g. peppermint and spearmint oils;

proteinaceous materials such as collagen;

preservatives;

opacifying agents;

colouring agents;

pH-adjusting agents; sweetening agents;

pharmaceutically acceptable carriers, e.g. starch, sucrose, water or water/alcohol systems etc.;

surfactants, such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants;

particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, tri etaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.

polymeric compounds which can enhance" the delivery of active ingredients such as antimicrobial agents can also be included;

buffers and salts to buffer the pH and ionic strength of the oral care composition; and

other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.

Liposomes may also be used to improve delivery or stability of active ingredients. The oral compositions may be in any form common in the art, e.g. toothpaste, gel, mousse, gum, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.

The toothpaste according to the invention is made by standard processes. An example of an 'oral composition according to the invention is found in the Example. It is made using processes known to the person skilled in the art.

EXAMPLE

Claims

1. An oral composition comprising zinc citrate, a betaine surfactant and an anionic surfactant, characterised in that the composition comprises the betaine derivative and the anionic surfactant in a weight ratio of from 0.5:1 to 2:1.
2. An oral composition according to claim 1 wherein the betaine surfactant is cocoamidopropyl betaine.
3. An oral composition according to any preceding claim wherein the anionic surfactant is sodium lauryl sulphate.
4. An oral composition according to ^any preceding claim wherein the composition comprises from 0.5 to 1.3% by weight anionic surfactant.
5. An oral composition according to any preceding claim wherein the composition comprises from 0.5 to 1.3% by weight betaine surfactant.
PCT/EP2005/002879 2004-03-25 2005-03-16 Oral composition WO2005092277A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04251741 2004-03-25
EP04251741.7 2004-03-25

Publications (1)

Publication Number Publication Date
WO2005092277A1 true true WO2005092277A1 (en) 2005-10-06

Family

ID=34930238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/002879 WO2005092277A1 (en) 2004-03-25 2005-03-16 Oral composition

Country Status (1)

Country Link
WO (1) WO2005092277A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076444A3 (en) * 2005-12-21 2007-08-16 Colgate Palmolive Co Improved oral compositions comprising zinc citrate and/or tocopherol agents
JP2014108948A (en) * 2012-12-03 2014-06-12 Lion Corp Liquid composition for oral cavity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169118A (en) *
WO1995001173A1 (en) * 1993-07-01 1995-01-12 Unilever N.V. Amphoteric surfactant for the treatment of aphthous ulcers
WO1996029049A1 (en) * 1995-03-20 1996-09-26 Unilever Plc Liquid cleansing formulations
US6169118B1 (en) * 1998-11-12 2001-01-02 Block Drug Company, Inc. Flavor blend for masking unpleasant taste of zinc compounds
WO2002026203A2 (en) * 2000-09-27 2002-04-04 Henkel Kommanditgesellschaft Auf Aktien Dental cleaning agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169118A (en) *
WO1995001173A1 (en) * 1993-07-01 1995-01-12 Unilever N.V. Amphoteric surfactant for the treatment of aphthous ulcers
WO1996029049A1 (en) * 1995-03-20 1996-09-26 Unilever Plc Liquid cleansing formulations
US6169118B1 (en) * 1998-11-12 2001-01-02 Block Drug Company, Inc. Flavor blend for masking unpleasant taste of zinc compounds
WO2002026203A2 (en) * 2000-09-27 2002-04-04 Henkel Kommanditgesellschaft Auf Aktien Dental cleaning agents
DE10047760A1 (en) * 2000-09-27 2002-04-11 Henkel Kgaa Dentifrice

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076444A3 (en) * 2005-12-21 2007-08-16 Colgate Palmolive Co Improved oral compositions comprising zinc citrate and/or tocopherol agents
JP2014108948A (en) * 2012-12-03 2014-06-12 Lion Corp Liquid composition for oral cavity

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