CN103442680B - The composition for oral cavity of liquid or liquid state and tongue fur attachment inhibitor - Google Patents

Abstract

The invention provides and a kind ofly there is efficient tongue fur attachment inhibition and taste is good, to the little liquid with good use sense of oral cavity mucosa irritation or liquid oral compositions and tongue fur attachment inhibitor.The feature of the composition for oral cavity of liquid or liquid state is, carbon number containing (A) fatty acid is fatty acid glyceride and (B) polyglutamate of 8 ~ 14, and the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.The feature of tongue fur attachment inhibitor is, is become to be grouped into (B) by above-mentioned (A) composition, and the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.

Description

The composition for oral cavity of liquid or liquid state and tongue fur attachment inhibitor

Technical field

The present invention relates to and a kind of there is the efficient tongue fur attachment liquid of inhibition or the composition for oral cavity of liquid state and tongue fur attachment inhibitor.

Background technology

In the past, as the technology removing tongue fur or the attachment of suppression tongue fur in oral cavity, patent documentation 1 (International Publication No. 2003/090704 pamphlet) proposed the technology utilizing actinidine (protease).But technique can damage oral mucosa.

In addition, although propose the physics clean technologies with tongue cleaner in patent documentation 2 (Japanese Patent Laid-Open 2001-161720 publication), the spatter property of tongue inside is insufficient in this case, and the method for scrubbing can damage mucosa.Although describe the tongue fur removal technology utilizing condensed phosphate in patent documentation 3 (Japanese Patent Laid-Open 10-182387 publication), be difficult to from taste, oral mucosa zest aspect agree, the space be also improved.

Therefore, the composition for oral cavity that efficient tongue fur attachment inhibition, use sense are good is expected to have.

On the other hand, saliva is the important factor purified in mouth, and the salivation minimizing caused due to xerostomias such as xerostomias can affect tongue fur attachment, is considered to accelerate tongue fur attachment.As salivation, polyglutamate promotes that composition is that effective this point is described in patent documentation 4 (International Publication No. 2005/049050 pamphlet), be known.Further, to propose in patent documentation 5 (Japanese Patent Laid-Open 2009-274967 publication) in polyglutamate and to have used the buccal spray compositions of the organic acid such as citric acid or its salt and glycerol effectively can improve dry sensation in mouth.

Prior art document

Patent documentation

Patent documentation 1: International Publication No. 2003/090704 pamphlet

Patent documentation 2: Japanese Patent Laid-Open 2001-161720 publication

Patent documentation 3: Japanese Patent Laid-Open 10-182387 publication

Patent documentation 4: International Publication No. 2005/049050 pamphlet

Patent documentation 5: Japanese Patent Laid-Open 2009-274967 publication

Summary of the invention

The present invention completes in view of the foregoing, and object is to provide a kind of to be had efficient tongue fur attachment inhibition and has the liquid of good use sense or the composition for oral cavity of liquid state and tongue fur attachment inhibitor.

The present inventor is for reaching above-mentioned purpose, obtaining a result after conscientiously studying, recognize the carbon number of (A) fatty acid be 8 ~ 14 fatty acid glyceride and (B) polyglutamate be carry out in 0.1 ~ 150 scope coordinating and using with the mass ratio of (B) composition/(A) composition, the liquid or liquid formulation with excellent tongue fur attachment inhibition can be obtained, such preparation is delicious, to oral cavity mucosa irritation, little and use sense is also good, thus completes the present invention.

Namely, the present inventor is surprised to find that: the specific fatty acid glyceride of (A) composition has tongue fur attachment inhibition, (B) composition polyglutamate is allocated into by suitably combining in (A) composition, tongue fur attachment inhibition significantly improves, not only play excellent tongue fur attachment inhibition, and eliminate the taste that caused by (A) composition and decline and stimulation etc., delicious, little to oral cavity mucosa irritation, use sense is good, can be applicable to tongue surface aptly.In addition, although known polyglutamate has salivation facilitation effect, but here is the new discovery of the present inventor: by also using polyglutamate in specific fatty acid glyceride, such as by Intraoral Spray or drip or gargle in oral cavity and be applicable to tongue surface, can good use sense be kept, play excellent tongue fur attachment inhibition.

Therefore, the invention provides following content.

(1) composition for oral cavity of a kind of liquid or liquid state, it is characterized by, contain: the carbon number of (A) fatty acid is fatty acid glyceride and (B) polyglutamate of 8 ~ 14, and the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.

(2) a kind of tongue fur attachment inhibitor, it is characterized by, by the carbon number of (A) fatty acid be 8 ~ 14 fatty acid glyceride and (B) polyglutamate form, the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.

According to the present invention, can provide a kind of there is efficient tongue fur attachment inhibition and taste well to the little liquid with good use sense of oral cavity mucosa irritation or liquid oral compositions and tongue fur attachment inhibitor.

Detailed description of the invention

Below, the present invention is further described.The invention is characterized in, be fatty acid glyceride and (B) polyglutamate of 8 ~ 14 by the carbon number of (A) fatty acid, also form with (B) composition with suitable ratio relative to (A) composition.

(A) composition is carbon number is 8 ~ 14, the preferably fatty acid glyceride of 8 ~ 11.The fatty acid glyceride of carbon number less than 8 not easily obtains, insufficient to the attachment inhibition of tongue fur more than 14.

As such fatty acid glyceride, caprylin, caprin, endecatylene acid glyceride, glyceryl laurate ester etc., particularly caprylin, caprin, endecatylene acid glyceride can be enumerated from the viewpoint of more suitable to tongue fur attachment inhibition.

(A) proportional quantity of composition fatty acid glyceride, from keeping effect (tongue fur attachment suppresses) clean mouth, aspect is considered, is 0.01 ~ 2% (quality %, below equally) of composition in its entirety, particularly preferably 0.1 ~ 1%.During less than 0.01%, the attachment inhibition of tongue fur plays insufficient sometimes, when proportioning is more than 2%, can remain offending taste after sometimes using, strong to oral cavity irritation on mucous membrane.

As (B) composition polyglutamate, be suitable for the sodium salt or the potassium salt that use polyglutamic acid.Suitable have the α of chemosynthesis or gamma-polyglutamic acid-or obtain from various bacterial strain as tunning natural α or the sodium salt of gamma-polyglutamic acid-or potassium salt, particularly preferably natural polyglutamate, more preferably as the gamma-polyglutamic acid-salt that raw material production rate is high.

Although there is no particular limitation for the viscosity of polyglutamate, according to viscosity (25 DEG C) preferably 10 ~ 200mPa.s of 4% aqueous solution that the algoscopy of aftermentioned use Brookfield viscometer measures, the particularly preferably scope of 30 ~ 150mPa.s.During less than 10mPa.s, sometimes do not have sufficient salivation, tongue fur removal effect plays insufficient.And sometimes fully can not reduce, suppress offending taste, oral mucosa to stimulate.During more than 200mPa.s, then formulation viscosity uprises sometimes, and the dispersibility in mouth is deteriorated, and can not play sufficient effect.

Viscosimetry

Add water in 200mL beaker 96g, make it dissolve completely while add gamma-polyglutamic acid-salt 4.0g with agitator stirring limit.Then, leave standstill after 1 hour in the thermostatic water bath of 25 DEG C, correctly measure the viscosity after 1 minute with BL type viscometer.

BL type viscometer: Tokyo gauge Brookfield viscometer model BL

Rotor: No.2 rotating speed: 60rpm measures temperature: 25 DEG C

(B) composition polyglutamate proportional quantity preferred composition entirety 0.05 ~ 5%, particularly preferably 0.1 ~ 2%.During less than 0.05%, the unpleasant taste of fatty acid glyceride and oral mucosa sometimes can not be suppressed to stimulate, or the secretion of saliva promotes insufficient, the attachment inhibition of tongue fur can not play satisfactorily.During more than 5%, the viscosity of preparation uprises sometimes, and preparation is difficult to spread in mouth, and the attachment inhibition of tongue fur plays insufficient.

(B) composition is relative to the proportion of (A) composition, in the mass ratio of (B)/(A), is 0.1 ~ 150, and preferably 0.2 ~ 15.Even if (A) proportional quantity of composition, (B) composition is respectively in above-mentioned scope, but the ratio of (B)/(A) less than 0.1 time, can not lower fully, suppress offending taste and oral mucosa to stimulate.During more than 150, formulation viscosity uprises, and the dispersibility in mouth is deteriorated, and does not play sufficient effect.

The form of composition for oral cavity of the present invention is liquid or liquid state.In addition, liquid oral composition herein refers to that formulated component is liquefiable transparent or semitransparent preparation, usually the solid state component that grinding agent etc. can not dissolve is not allocated into, allocate such as wetting agent, surfactant, solvent into, allocate sweeting agent, spice, effective ingredient etc. as required into further.Liquid oral compositions refers to that shape retention is low, has the preparation of the gel of mobility etc., and the solid state components such as grinding agent do not dissolve and disperse wherein that also it doesn't matter.Such as grinding agent, wetting agent, viscosifier, surfactant, solvent be can allocate into, sweeting agent, spice, effective ingredient etc. allocated as required into further.

The present composition is particularly tongue fur surface spray or drip or gargle in oral cavity etc. and directly can be useful in tongue surface and use in oral cavity preferably, further also can after a procedure with toothbrush brush tongue surface.Dosage form is the suitable dosage forms used so preferably, particularly, toothpaste agent, spray, the dosage forms such as agent, capsule of dripping such as the collutory such as collutory, liquid tooth paste, liquid toothpaste can be used, but from the viewpoint of the Portability etc. that can arbitrarily use in right amount, particularly preferably use spray wherein or agent of dripping whenever and wherever possible.

According to corresponding form, dosage form in the scope not hindering effect of the present invention, other the known compositions beyond above-mentioned (A) and (B) composition can be allocated as required in the present composition, by these compositions and water mixing, can modulate with usual way.

As grinding agent, the grinding agent used in usual composition for oral cavity can be used.Particularly, the silica-based grinding agents such as settleability silicon dioxide, aluminium silicate can be used, the calcium phosphate compounds such as calcium hydrogen phosphate two water thing and anhydride, dalcium biphosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, calcium hydroxide, one or more of aluminium hydroxide salt etc. carry out proportioning (proportional quantity is generally 0 ~ 50%, particularly 10 ~ 50%).

As surfactant, anionic surfactant, non-ionic surface active agent, amphoteric surfactant can be allocated into.

As anion surfactant, there are the alkyl sodium sulfate such as sodium lauryl sulfate, myristyl sulfate, N-sodium N-lauroyl sarcosinate, the N-sarcosinate etc. such as N-myristoyl-N-methylaminoacetic acid sodium.

As nonionic surfactant, for example there are the sugar alcohol fatty acid esters such as polyoxyethylene hydrogenated Oleum Ricini, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, the polyol fatty acid esters such as polyoxyethylene glycerol fatty acid esters, cithrol, ether type or the ester type surfactants such as polyoxyethylene alkyl ether, poloxalkol, polyoxyethylene alkyl phenyl ether, the fatty acid alkanol amides classes such as lauric acid diethyl amide.As cationic surfactant, alkylammonium can be enumerated, alkyl benzyl ammonium salt etc.

As amphoteric surfactant, acetic acid betaine type amphoteric surfac-tant, imidazoline type amphoteric surfactant etc. can be enumerated.

The proportional quantity of these surfactants can be set as 0 ~ 10%, can be set as 0.1 ~ 5.0% especially

As viscosifier, xanthan gum, carrageenin, hydroxyethyl-cellulose, sodium alginate, polyvinyl alcohol, sodium carboxymethyl cellulose etc. (proportional quantity normally 0 ~ 5%, particularly 0.5 ~ 3%) can be enumerated.

As wetting agent, the sugar alcohols such as such as Sorbitol, maltose alcohol, lactose, the polyhydric alcohol such as glycerol, ethylene glycol, Polyethylene Glycol, propylene glycol, 1,3 butylene glycol (proportional quantity normally 2 ~ 70%).

As solvent, usually use water, its content can more than 20%.And can allocate the alcohols such as the low-grade monobasic alcohol of the carbon numbers 2 ~ 4 such as such as ethanol, isopropyl alcohol, butanols, propanol into, its proportional quantity can be set as 0 ~ 20%.

In addition, as sweeting agent, xylitol, maltose alcohol, glucide, saccharin sodium, stevioside, aspartame etc. can be allocated into.

As coloring agent, the water colo(u)r that the safeties such as No. 1, blueness, No. 3, green, No. 4, yellow, No. 105, redness are high can be added.

And, as pH adjusting agent, the salt of citric acid, malic acid, tartaric acid, succinic acid or these acid can be added, phosphoric acid, phosphate (sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium phosphate etc.), carbonate, bicarbonate etc.

In addition, the pH of compositions is with 3 ~ 10, and particularly 5 ~ 8 is suitable.

As spice, there are Oleum menthae, spearmint oil, eucalyptus oil, wintergreen oil, Oleum Caryophylli, thyme oil, sage oil, cardamom oil, oil of rosemary, Majorana hortensis oil, Fructus Citri Limoniae oil, Semen Myristicae oil, Oleum lavandula angustifolia, Spilanthes acmella wet goods natural essential oil, and MENTHOL, L-carvone, cinnamic aldehyde, orange oil, anethole, 1, 8-Cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, Camphora, Borneolum Syntheticum, pinene, the fragrance component contained in the above-mentioned natural essential oil such as affinin, also has ethyl acetate, ethyl n-butyrate., isoamyl acetate, hexanal, hexenoic aldehyde, methyl 2-aminobenzoate, methyl phenyl ethyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furanone, maltol, ethyl maltol, gamma/delta-decalactone, gamma/delta-ten one carbon lactone, N-ethyl-p-menthan-3-Methanamide, menthyl lactate, the fragrance components such as L-diglycol carbonate menthyl ester, also have the Fructus Mali pumilae that several fragrance component or natural essential oil can combine, Fructus Musae, Fructus Fragariae Ananssae, blue berry, Fructus Melo, Fructus Persicae, Fructus Ananadis comosi, Fructus Vitis viniferae, muscat grape, wine, Fructus Pruni pseudocerasi, Fructus Cucurbitae moschatae, coffee, brandy, the mediation spice of the tastes such as Yoghourt.What can use in these spice in the scope not hindering effect of the present invention is one kind or two or more, usually can allocate 0.00001 ~ 3% in compositions.

As effective ingredient, such as western pyrrole chloramines can be added, Chlorhexidine hydrochloride, chlorhexidine gluconate, Benzalkonii Chloridum, the cationic antibacterial such as benzethonium chloride, the nonionic antibacterial such as isopropyl methyl phenol, tranexamic acid, the antiinflammatories such as episilon amino caproic acid, glucanase, become the enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate, the fluorides such as stannous fluoride, the vitamin c class such as ascorbic acid, beta-cholestanol, enoxolone salt, enoxolone class, hydrocholesterol, chlorophyll, sodium copper chlorophllin, thyme, Radix Scutellariae, Flos Caryophylli, the plant extracts such as Radix Hamamelidis Mollis, copper gluconate, caropeptide, polyphosphate sodium, water-soluble inorganic phosphate cpd, polyvinylpyrrolidone, tartar preventing agent, tartar preventing agent, potassium nitrate, aluctyl. etc.In addition, the addition of these effective ingredient can be set in the scope not hindering effect of the present invention.

Accepting container can use the known containers being suitable for composition for oral cavity collecting.Material for example there are polyethylene, polypropylene, polyethylene terephthalate, polyacetals etc., can use the container conformed to dosage form.

For spray, can the container of structure of spraying medicament just have no particular limits as long as have.Particularly, the container body such as plastic bottle that possesses collecting content can be used and have the aerosol apparatus part of the spray structures such as pump disperser, carried out the container of spraying by pressing and the pressing position of the close-connected aerosol apparatus part in container body upper opening place, or by extruding the container etc. that the container body containing content carries out spraying.

As long as drip agent have can be applicable in oral cavity as drop, particularly the container of the structure on tongue surface just have no particular limits.Can use and possess cap of spraying nozzle, the squeeze receptacle main body of dripping and produce the container of drop, and possess dropper, produce the container etc. of drop.

The present invention can provide a kind of tongue fur attachment inhibitor, it is fatty acid glyceride and (B) polyglutamate of 8 ~ 14 by the carbon number of (A) fatty acid, and the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.In the case, detailed formulated component or its proportional quantity, ratio etc. all same as described above.

Embodiment

Below provide embodiment and comparative example illustrates the present invention, but the present invention is not limited to following embodiment.In addition, the % in following example is being not particularly limited lower expression quality %.In addition, following viscosity is the value that Brookfield viscometer same with said method measures.

(embodiment 1 ~ 18, comparative example 1 ~ 6)

Carry out following evaluation with the composition for oral cavity of composition shown in following method modulomenter 1 ~ 4.Result merges record in table 1 ~ 4.

The modulation > of < preparation

Each composition is weighed sampling, uses blender hybrid modulation.Modulation solution is about 30mL to be filled in aerosol apparatus (Yoshino Kogyosho Co., Ltd manufactures, Y-70 disperser, capacity 30mL, the bottle that polyethylene terephthalate is made), obtains test preparation.

The attachment of < tongue fur inhibition, use sense (taste), oral mucosa irritating evaluation >

To feeling that 10 respondents of xerostomia test at ordinary times.First test by the tongue fur of respondent is removed totally with toothbrush by expert.Test preparation is sprayed 5 times to tongue.Use 2 days 1 day 6 times ~ 10 times.Duration of test stops the use with agent in collutory, mouth of cleaning of lingual surface.After off-test, the lingual surface of undertaker's observation survey object, calculates the area ratio (%) that tongue fur covers, according to the meansigma methods of respondent with following benchmark carry out ◎ ~ × evaluation.

About use sense (taste), oral mucosa zest, with following benchmark (7 grades) by respondent oneself evaluate, calculate the meansigma methods of scoring, with following benchmark carry out ◎ ~ × evaluation.

The metewand of tongue fur attachment inhibition;

◎ more than 0, less than 15%

More than 0 15%, less than 30%

△ more than 30%, less than 40%

More than × 40%

The metewand of use sense (taste);

7 points of complete imperceptible offending abnormal flavour

6 points of almost imperceptible offending abnormal flavour

Not too feel offending abnormal flavour for 5 points

4 points are difficult to evaluate whether have abnormal flavour

Feel slightly offending abnormal flavour for 3 points

Obviously feel offending abnormal flavour for 2 points

Clearly feel offending abnormal flavour for 1 point

The irritating metewand of oral mucosa;

7 points of complete imperceptible stimulations

6 points of almost imperceptible stimulations

Not too feel stimulation for 5 points

4 points are difficult to evaluate whether have stimulation

Feel slightly stimulation for 3 points

Obviously feel stimulation for 2 points

Clearly feel stimulation for 1 point

Calculate above-mentioned each meansigma methods evaluating scoring, judge with following scoring benchmark.

◎ more than 6 points

More than 0 4.5 points, less than 6 points

△ more than 3.5 points, less than 4.5 points

× less than 3.5 points

[table 1]

[table 2]

[table 3]

[table 4]

[embodiment 19 ~ 31]

The composition for oral cavity of composition shown in method for making modulomenter 5 ~ 7 similar to the above.Embodiment 19 ~ 23 is filled in automiser spray same as described above, embodiment 24 ~ 28 is filled into the agent container that drips, and (Rong Resin Industry Co., Ltd. manufactures, elite series DE20, material: polyethylene, 20mL), embodiment 29 ~ 31 is filled into collutory container, and (Yoshino Kogyosho Co., Ltd manufactures, polyethylene terephthalate system, 250mL), evaluate according to above-mentioned evaluation methodology.

In addition, about agent of dripping, with adhering to after the identical method of situation that inhibition evaluates removes tongue fur with above-mentioned tongue fur, with dripping on tongue, the method for 3 uses agent of dripping.In addition, about collutory, after similarly removing tongue fur, the method spued after gargling about 30 seconds with about 10mL uses collutory.Evaluate with said method, result is as shown in table 5 ~ 7.

[table 5]

Spray

[table 6]

To drip agent

[table 7]

Collutory

In addition, use described in being described in detail as follows of raw material.

Caprylin: Taiyo Kagaku Co., Ltd. manufactures, trade name Sunsoft700P-2

Caprin: Taiyo Kagaku Co., Ltd. manufactures, Sunsoft760

Endecatylene acid glyceride: Nikko Chemicals Co., Ltd manufactures, trade name NIKKOL MGU

Glyceryl laurate ester: Taiyo Kagaku Co., Ltd. manufactures, trade name Sunsoft750

Tripalmitin: Japanese latex (エ マ Le ジ ヨ Application) Co., Ltd. manufactures, trade name GMS-P

Polyglutamic acid sodium: Mingzhi's food materials (Off one De マ テ リ ア) Co., Ltd. manufacture, trade name Mingzhi polyglutamic acid, viscosity as table in remember.

Polyglutamic acid potassium: Mingzhi's food materials (Off one De マ テ リ ア) Co., Ltd. manufacture, viscosity as table in remember.

Tetrasodium pyrophosphate: peaceful Chemical Industries Co., Ltd. manufactures.

In addition, the spice A ~ F of use is as shown in table 8 ~ 14.

[table 8]

Spice

Composition (%)	Spice A	Spice B	Spice C	Spice D	Spice E	Spice F
							Oleum menthae	25	20	10	8	0	5
Oleum menthae is removed and to be slipped before 20% point	25	25	10	8	10	10
							The Oleum menthae of 15% terpenes part is removed in film process	0	0	10	0	5	20
Spearmint oil	1	5	1	0	0	1
							Spearmint oil slips after removing and slipping before 15% point point	10	0	5	1	2	1
Japanese peppermint oil	1	1	0	20	0	1
							Japanese peppermint oil is removed and to be slipped before 30% point	1	1	10	10	2	4
Carvone	0	1	0	7	1	5
							Linalool	1	1	1	0	1	1
1, 8-Cineole	1	1	1	1	10	1
							Menthofuran	1	1	0	2	0	0
Camphora	1	1	1	1	1	0
							Menthone	1	1	1	0	1	0
Eugenol	1	1	1	1	1	2
							Menthyl acetate	1	0	0	1	1	1
Methyl salicylate	5	1	1	1	0	10
							Mediation spice 1 (table 9)	0.5	0	05	5	0.5	0
Mediation spice-2 (table 10)	1	0	1	10	1	0
							Mediation spice-3 (table 11)	1	0	1	1	1	0
Mediation spice 4 (table 12)	1	0	1	0.1	10	0
							Mediation spice 5 (table 13)	05	0	0.5	0.5	0.1	0
Mediation spice-6 (table 14)	1	0	1	1	1	0
							Propylene glycol	20	40	43	21.4	51.4	38
Add up to	100	100	100	100	100	100

[table 9]

The spice 1 that is in harmonious proportion forms

Fructus Citri Limoniae oil	1 part
		Fructus Citri Limoniae oil is removed and to be slipped before 95% point	1 part
Lime oil	1 part
		Mandarin oil	1 part
Grapefruit	1 part
		Oran Fructus Citri grandis oil	1 part
Grape-fruit seed oil	1 part
		Citral	1 part
Glyceryl triacetate	2 parts
		Add up to	10 parts

In table, part is mass parts (lower same).[table 10]

The spice 2 that is in harmonious proportion forms

Eucalyptus oil	1 part
		Oleum Caryophylli	1 part
Thyme oil	1 part
		Sage oil	1 part
Cardamom oil	1 part
		Fructus Coriandri oil	1 part
Oil of rosemary	1 part
		Laurel fat	1 part
Flos Matricariae chamomillae oil	1 part
		Caraway oil	1 part
Basil oil	1 part
		Propylene glycol	1 part
Add up to	12 parts

[table 11]

The spice 3 that is in harmonious proportion forms

Wintergreen oil	1 part
		Olibanum oil	1 part
Oleum lavandula angustifolia	1 part
		Orange blossom oil	1 part
Citronella oil	1 part
		Rong Li caul-fat	1 part
Oleum Rosae Rugosae	1 part
		Rose absolute	1 part
Rhizoma et radix valerianae absolute oil	1 part
		Fructus Mangifera Indicae absolute oil	1 part
Dovetail flower concrete	1 part
		Orange Blossom	1 part
Propylene glycol	1 part
		Add up to	13 parts

[table 12]

The spice 4 that is in harmonious proportion forms

Menthyl lactate	1 part
		N-replacement-to terpane-3-Methanamide	1 part
3-L-menthoxypropane-1,2-glycol	1 part
		Herba Menthae glycerin ether	1 part
Affinin	1 part
		Monomenthyl succinate	1 part
Linalool oxide	1 part
		Vanillin butyl ether	1 part
Isopulegol	1 part
		Fructus Capsici extract	1 part
Ginger oil resin	1 part
		Pepper oleoresin	1 part
Capsicum oleoresin	1 part
		Propylene glycol	1 part
Add up to	14 parts

[table 13]

The spice 5 that is in harmonious proportion forms

Maltol	1 part
		Ethyl maltol	1 part
Vanillin	1 part
		Ethyl vanillin	1 part
Furanone	1 part
		Ethylcyclopentenolone	1 part
Methyl cyclopentenyl ketone	1 part
		2-Methyl Butyric Acid	1 part
Propanoic acid	1 part
		P-met hoxycinnamic aldehyde	1 part
Propylene glycol	1 part
		Add up to	11 parts

[table 14]

The spice 6 that is in harmonious proportion forms

Cis-3-hexenol	1 part
		Trans-2-hexenoic aldehyde	1 part
Ethyl n-butyrate.	1 part
		11 carbon lactones	1 part
Decalactone	1 part
		Isoamyl acetate	1 part
Benzaldehyde	1 part
		Exceed 600	1 part
Ethyl-2-Methyl butyl ester	1 part
		Benzylalcohol	1 part
Alpha-terpineol	1 part
		Linalyl acetate	1 part
Ethyl phenylglycidate	1 part
		Phenethyl alcohol	1 part
Allyl hexanoate	1 part
		Capryl alcohol	1 part
Methyl cinnamate	1 part
		Heptyl carboxylate methyl ester	1 part
Ionoionone	1 part
		Ethyl-Beta-methyl thiopropionate	1 part
Cis-6-nonenol	1 part
		Watermelon ketone	1 part
Methyl jasmonate	1 part
		Propylene glycol	1 part
Add up to	24 parts

Claims (6)

1. the composition for oral cavity of a liquid or liquid state, it is characterized in that, contain: the carbon number of (A) fatty acid is fatty acid glyceride 0.01 ~ 2 quality % and (B) polyglutamate 0.05 ~ 5 quality % of 8 ~ 14, and the mass ratio of (B) composition/(A) composition is in the scope of 0.1 ~ 150.

2. composition for oral cavity as claimed in claim 1, its (A) composition is the carbon number of fatty acid is the fatty acid glyceride of 8 ~ 11.

3. composition for oral cavity as claimed in claim 1 or 2, the proportional quantity of its (A) composition is 0.1 ~ 1 quality %.

4. composition for oral cavity as claimed in claim 1 or 2, the proportional quantity of its (B) composition is 0.1 ~ 2 quality %.

5. composition for oral cavity as claimed in claim 1 or 2, it is by Intraoral Spray or drip, or gargles in oral cavity, is applicable to the composition for oral cavity on tongue surface.

6. a tongue fur attachment inhibitor, it is characterized in that, containing fatty acid glyceride 0.01 ~ 2 quality % and (B) polyglutamate 0.05 ~ 5 quality % that the carbon number of (A) fatty acid is 8 ~ 14, the mass ratio of (B) composition/(A) composition 0.1 ~ 150 scope.