CN103442680A - Liquid or liquefied oral composition and agent for inhibiting adherence of tongue plaque - Google Patents

Abstract

Provided are a liquid or liquefied oral composition and an agent for inhibiting the adherence of tongue plaque that exhibit good tongue plaque adherence-inhibiting effects, taste good, have low irritancy to oral mucosa, and feel good when used. The liquid or liquefied oral composition is characterized in containing (A) a glycerin fatty acid ester with a C8-14 fatty acid and (B) a polyglutamate, and in the mass ratio of component (B)/component (A) being in the range of 0.1 - 150. The tongue plaque adherence-inhibiting agent is characterized in being obtained from said component (A) and component (B), and in the mass ratio of component (B)/component (A) being in the range of 0.1 - 150.

Description

Liquid or liquid composition for oral cavity and tongue fur attachment inhibitor

Technical field

The present invention relates to a kind of liquid or liquid composition for oral cavity and tongue fur attachment inhibitor that efficient tongue fur adheres to inhibition that have.

Background technology

In the past, as removing in oral cavity tongue fur or suppressing the technology that tongue fur adheres to, patent documentation 1 (No. 2003/090704 pamphlet of International Publication) had proposed to utilize the technology of actinidine (protease).But technique can damage oral mucosa.

In addition, although proposed the physics clean technologies with the tongue cleaner in patent documentation 2 (Japanese Patent Laid-Open 2001-161720 communique), the spatter property of tongue inside is insufficient in this case, and the method for scrubbing can damage mucosa.Although put down in writing the tongue fur removal technology of utilizing condensed phosphate in patent documentation 3 (Japanese patent laid-open 10-182387 communique), from taste, oral mucosa zest aspect, be difficult to agree, the space also be improved.

Therefore, expect that having efficient tongue fur adheres to inhibition, makes composition for oral cavity with a good sense.

On the other hand, saliva is the important factor purified in mouth, and the salivation minimizing caused due to xerostomias such as xerostomias can affect tongue fur adheres to, and is considered to accelerate tongue fur and adheres to.Polyglutamate promotes that as salivation composition is that effective this point is described in patent documentation 4 (No. 2005/049050 pamphlet of International Publication), is known.Further, proposed in polyglutamate in patent documentation 5 (Japanese Patent Laid-Open 2009-274967 communique) and used the mouthspray compositions of the organic acid such as citric acid or its salt and the glycerol dry sensation in effectively improving mouth.

The prior art document

Patent documentation

Patent documentation 1: No. 2003/090704 pamphlet of International Publication

Patent documentation 2: Japanese Patent Laid-Open 2001-161720 communique

Patent documentation 3: Japanese patent laid-open 10-182387 communique

Patent documentation 4: No. 2005/049050 pamphlet of International Publication

Patent documentation 5: Japanese Patent Laid-Open 2009-274967 communique

Summary of the invention

The present invention In view of the foregoing completes, and purpose is to provide a kind of liquid or liquid composition for oral cavity and tongue fur attachment inhibitor that efficient tongue fur adheres to inhibition and has good use sense that have.

The inventor is for reaching above-mentioned purpose, after conscientiously studying, obtaining a result, the fatty acid glyceride that to recognize the carbon number of (A) fatty acid be 8～14 and (B) polyglutamate take that (B) composition/(A) mass ratio of composition is coordinated and uses in 0.1～150 scope, can obtain and there is liquid or the liquid formulation that excellent tongue fur adheres to inhibition, such preparation is delicious, little and use sense also good to the oral cavity mucosa irritation, thus the present invention completed.

; the inventor is surprised to find that: (A) the specific fatty acid glyceride of composition has tongue fur and adheres to inhibition; by in (A) composition, suitably combining and allocate (B) composition polyglutamate into; tongue fur adheres to inhibition and significantly improves; not only bring into play excellent tongue fur and adhered to inhibition; and eliminated that the taste that caused by (A) composition descends and stimulation etc., and delicious, little to the oral cavity mucosa irritation, make with a good sensely, can be applicable to aptly the tongue surface.In addition, although known polyglutamate has the salivation facilitation effect, but be below the inventor's new discovery: by also use polyglutamate in specific fatty acid glyceride, for example by the oral cavity internal spraying or drip or oral cavity in gargle and be applicable to the tongue surface, can keep good use sense, bring into play excellent tongue fur and adhere to inhibition.

Therefore, the invention provides following content.

(1) a kind of liquid or liquid composition for oral cavity, it is characterized by, contain: the fatty acid glyceride that (A) carbon number of fatty acid is 8～14 and (B) polyglutamate, and (B) mass ratio of the composition of composition/(A) in 0.1～150 scope.

(2) a kind of tongue fur attachment inhibitor, is characterized by, the fatty acid glyceride that is 8～14 by the carbon number of (A) fatty acid and (B) polyglutamate form, (B) mass ratio of the composition of composition/(A) is in 0.1～150 scope.

According to the present invention, can provide a kind of and there is efficient tongue fur and adhere to the well little liquid with good use sense or liquid composition for oral cavity and the tongue fur attachment inhibitor to the oral cavity mucosa irritation of inhibition and taste.

The specific embodiment

Below, further describe the present invention.The invention is characterized in, the fatty acid glyceride that is 8～14 by the carbon number of (A) fatty acid and (B) polyglutamate, with respect to (A) composition with suitable ratio and form with (B) composition.

(A) composition is that carbon number is 8～14, preferably 8～11 fatty acid glyceride.The fatty acid glyceride of carbon number less than 8 be difficult for to obtain, surpass 14 to tongue fur to adhere to inhibition insufficient.

As such fatty acid glyceride, can enumerate caprylin, caprin, endecatylene acid glyceride, glyceryl laurate ester etc., particularly caprylin, caprin, endecatylene acid glyceride from tongue fur is adhered to the inhibition aspect consider more suitable.

(A) proportional quantity of composition fatty acid glyceride, from keep mouthful, clean effect (tongue fur adheres to inhibitions) aspect is considered, is 0.01～2% (quality %, below equally) of composition in its entirety, particularly preferably 0.1～1%.During less than 0.01%, sometimes tongue fur to adhere to inhibition performance insufficient, when proportioning surpasses 2%, can residual offending taste after sometimes using, strong to the oral cavity mucosa irritation.

As (B) composition polyglutamate, the sodium salt of suitable use polyglutamic acid or potassium salt.Sodium salt or the potassium salt of the suitable α that chemosynthesis is arranged or gamma-polyglutamic acid-or the natural α obtained from various bacterial strains as tunning or gamma-polyglutamic acid-, natural polyglutamate particularly preferably, the more preferably high gamma-polyglutamic acid-salt as the raw material production rate.

Although there is no particular limitation for the viscosity of polyglutamate, the viscosity (25 ℃) of 4% aqueous solution of measuring according to the algoscopy of aftermentioned use Brookfield viscometer is 10～200mPa.s, the particularly preferably scope of 30～150mPa.s preferably.During less than 10mPa.s, sometimes there is no sufficient salivation, the performance of tongue fur removal effect is insufficient.And sometimes can not fully reduce, suppress offending taste, oral mucosa and stimulate.While surpassing 200mPa.s, preparation viscosity uprises sometimes, and the dispersibility variation in mouth, can not bring into play sufficient effect.

Viscosimetry

Add water 96g in the 200mL beaker,, limit is stirred limit with agitator and is added gamma-polyglutamic acid-salt 4.0g that it is dissolved fully.Then, in the thermostatic water bath of 25 ℃ after standing 1 hour, with BL type viscometer, correctly measure the viscosity after 1 minute.

BL type viscometer: Tokyo gauge Brookfield viscometer model BL

Rotor: No.2 rotating speed: 60rpm measures temperature: 25 ℃

(B) 0.05～5% of the proportional quantity preferred composition integral body of composition polyglutamate, particularly preferably 0.1～2%.During less than 0.05%, sometimes can not suppress the unpleasant taste of fatty acid glyceride and oral mucosa stimulates, or the secretion of saliva promote insufficient, the adhering to inhibition and can not bring into play satisfactorily of tongue fur.While surpassing 5%, the viscosity of preparation uprises sometimes, and preparation is difficult to spread in mouth, and the inhibition of adhering to of tongue fur is brought into play insufficient.

(B) composition, with respect to the proportion of (A) composition, in the mass ratio of (B)/(A), is 0.1～150, preferably 0.2～15.Even (A) proportional quantity of composition, (B) composition is respectively in above-mentioned scope, but during ratio less than 0.1 (B)/(A), can not lower fully, suppress offending taste and oral mucosa stimulates.Surpass at 150 o'clock, preparation viscosity uprises, and the dispersibility variation in mouthful, do not bring into play sufficient effect.

The form of composition for oral cavity of the present invention is liquid or liquid state.In addition, liquid oral composition herein refers to that formulated component is liquefiable transparent or semitransparent preparation, usually do not allocate the solid state component that grinding agent etc. can not dissolve into, allocate for example wetting agent, surfactant, solvent into, further allocate as required sweeting agent, spice, effective ingredient etc. into.Liquid composition for oral cavity refers to that shape retention is low, have the preparation of the gel etc. of mobility, and the solid state components such as grinding agent do not dissolve and disperse that wherein also it doesn't matter.For example grinding agent, wetting agent, viscosifier, surfactant, solvent be can allocate into, sweeting agent, spice, effective ingredient etc. further allocated as required into.

The present composition is preferably in oral cavity particularly the tongue fur surface spray or drips or gargle in oral cavity etc. and can directly be useful in the tongue surface and use, further also can be with toothbrush brush tongue surface after use.Dosage form is the dosage forms of suitable such use preferably, particularly, can use the dosage forms such as the toothpaste agent such as collutory, liquid tooth paste, liquid toothpaste, spray, the agent of dripping, capsule such as collutory, but consider from the aspects such as Portability that can arbitrarily use in right amount whenever and wherever possible, particularly preferably use spray or the agent of dripping wherein.

According to corresponding form, dosage form in the scope that does not hinder effect of the present invention, can allocate as required above-mentioned (A) and (B) other known compositions beyond composition in the present composition into, these compositions and water can be mixed, be modulated with usual way.

As grinding agent, can use the grinding agent used in common composition for oral cavity.Particularly, can use the silica-based grinding agents such as settleability silicon dioxide, aluminium silicate, the calcium phosphate compounds such as calcium hydrogen phosphate two water things and anhydride, dalcium biphosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, calcium hydroxide, one or more of aluminium hydroxide salt etc. carry out proportioning (proportional quantity is generally 0～50%, particularly 10～50%).

As surfactant, can allocate anionic surfactant, non-ionic surface active agent, amphoteric surfactant into.

As anion surfactant, there are the alkyl sodium sulfates such as sodium lauryl sulfate, myristyl sodium sulfate, N-sodium N-lauroyl sarcosinate, the N-acyl group sodium sarcosinates such as N-myristoyl-N-methylaminoacetic acid sodium etc.

As nonionic surfactant, the sugar alcohol fatty acid esters such as polyoxyethylene hydrogenated Oleum Ricini, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester are arranged for example, the polyol fatty acid esters such as polyoxyethylene fatty acid glyceride, cithrol, ether type or the ester type surfactants such as polyoxyethylene alkyl ether, poloxalkol, polyoxyethylene alkyl phenyl ether, the fatty acid alkanol amides classes such as lauric acid diethyl amide.As cationic surfactant, can enumerate alkylammonium, alkyl benzyl ammonium salt etc.

As amphoteric surfactant, can enumerate acetic acid betaine type amphoteric surfac-tant, imidazoline type amphoteric surfactant etc.

The proportional quantity of these surfactants can be set as 0～10%, can be set as 0.1～5.0% especially

As viscosifier, can enumerate xanthan gum, carrageenin, hydroxyethyl-cellulose, sodium alginate, polyvinyl alcohol, sodium carboxymethyl cellulose etc. (proportional quantity normally 0～5%, particularly 0.5～3%).

As wetting agent, sugar alcohols such as Sorbitol, maltose alcohol, lactose, the polyhydric alcohol such as glycerol, ethylene glycol, Polyethylene Glycol, propylene glycol, 1,3 butylene glycol (proportional quantity normally 2～70%).

As solvent, usually make water, its content can be more than 20%.And, can allocate the alcohols such as low-grade monobasic alcohol of carbon numbers 2～4 such as ethanol, isopropyl alcohol, butanols, propanol into, its proportional quantity can be set as 0～20%.

In addition, as sweeting agent, can allocate xylitol, maltose alcohol, glucide, saccharin sodium, stevioside, aspartame etc. into.

As coloring agent, the safe water colo(u)r such as can add blue No. 1, green No. 3, yellow No. 4, red No. 105.

And, as pH adjusting agent, can add citric acid, malic acid, tartaric acid, succinic acid or these sour salt, phosphoric acid, phosphate (sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium phosphate etc.), carbonate, bicarbonate etc.

In addition, the pH of compositions is with 3～10, and particularly 5～8 is suitable.

As spice, there are Oleum menthae, spearmint oil, eucalyptus oil, wintergreen oil, Oleum Caryophylli, thyme oil, sage oil, cardamom oil, oil of rosemary, Majorana hortensis oil, Fructus Citri Limoniae oil, Semen Myristicae oil, Oleum lavandula angustifolia, Spilanthes acmella wet goods natural essential oil, and MENTHOL, the L-carvone, cinnamic aldehyde, orange oil, anethole, 1, 8-Cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, Camphora, Borneolum Syntheticum, pinene, the fragrance component contained in the above-mentioned natural essential oil such as affinin, also have ethyl acetate, ethyl n-butyrate., isoamyl acetate, hexanal, hexenoic aldehyde, methyl 2-aminobenzoate, methyl phenyl ethyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furanone, maltol, ethyl maltol, gamma/delta-decalactone, gamma/delta-11 carbon lactone, the N-ethyl-to terpane-3-Methanamide, menthyl lactate, the fragrance components such as L-diglycol carbonate menthyl ester, the Fructus Mali pumilae that also has several fragrance components or natural essential oil to combine, Fructus Musae, Fructus Fragariae Ananssae, blue berry, Fructus Melo, peach, Fructus Ananadis comosi, Fructus Vitis viniferae, muscat grape, wine, Fructus Pruni pseudocerasi, Fructus Cucurbitae moschatae, coffee, brandy, the mediation spice of the tastes such as Yoghourt.Can use one kind or two or more in these spice in the scope that does not hinder effect of the present invention, in compositions, usually can allocate 0.00001～3% into.

As effective ingredient, can add for example western pyrrole chloramines, Chlorhexidine hydrochloride, chlorhexidine gluconate, Benzalkonii Chloridum, the cationic antibacterial such as benzethonium chloride, the nonionic antibacterial such as isopropyl methyl phenol, tranexamic acid, the antiinflammatories such as episilon amino caproic acid, glucanase, become the enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate, the fluorides such as stannous fluoride, the vitamin c class such as ascorbic acid, beta-cholestanol, the enoxolone salt, the enoxolone class, hydrocholesterol, chlorophyll, sodium copper chlorophllin, thyme, Radix Scutellariae, Flos Caryophylli, the plant extracts such as Radix Hamamelidis Mollis, copper gluconate, caropeptide, polyphosphate sodium, the water-soluble inorganic phosphate cpd, polyvinylpyrrolidone, the tartar preventing agent, the tartar preventing agent, potassium nitrate, aluctyl. etc.In addition, the addition of these effective ingredient can be set in the scope that does not hinder effect of the present invention.

Accepting container can be used and be suitable for the known containers that composition for oral cavity is accommodated.Material has polyethylene, polypropylene, polyethylene terephthalate, polyacetals etc. for example, can use the container conformed to dosage form.

For spray, so long as there is the container of structure that can spraying medicament, just have no particular limits.Particularly, can use container bodies such as possessing the plastic bottle of accommodating content and the aerosol apparatus part of the spray structures such as pump disperser is arranged, by pressing the container of being sprayed in position of pressing with the close-connected aerosol apparatus part in container body upper opening place, or contain container that the container body of content sprayed etc. by extruding.

Drip agent so long as have as drop can be applicable in oral cavity, particularly the container of the structure on tongue surface just has no particular limits.Can use the cap of spraying nozzle that possesses the use of dripping, squeeze receptacle main body to produce the container of drop, and possess dropper, produce the container of drop etc.

The present invention can provide a kind of tongue fur attachment inhibitor, its fatty acid glyceride that is 8～14 by the carbon number of (A) fatty acid and (B) polyglutamate, and (B) mass ratio of the composition of composition/(A) is in 0.1～150 scope.In the case, detailed formulated component or its proportional quantity, ratio etc. are all same as described above.

Embodiment

Below provide embodiment and comparative example illustrates the present invention, but the present invention is not limited to following embodiment.In addition, the % in following example is being not particularly limited lower expression quality %.In addition, following viscosity is the value of measuring with Brookfield viscometer equally with said method.

(embodiment 1～18, comparative example 1～6)

With the composition for oral cavity formed shown in following method modulomenter 1～4 and carry out following evaluation.Result merges record in table 1～4.

The modulation of<preparation >

By each composition weighing sampling, use the blender hybrid modulation.To modulate the about 30mL of solution and be filled in aerosol apparatus (Yoshino Kogyosho Co., Ltd manufactures, Y-70 disperser, capacity 30mL, the bottle that polyethylene terephthalate is made), obtain the test preparation.

<tongue fur adheres to inhibition, uses sense (taste), the irritating evaluation of oral mucosa >

10 respondents that feel at ordinary times xerostomia are tested.At first after removing totally with toothbrush by respondent's tongue fur by the expert, start test.Test is sprayed 5 times to tongue with preparation.Use 2 days for 1 day 6 times～10 times.Duration of test stop lingual surface clean and collutory, mouthful in the use of agent.After off-test, the lingual surface of undertaker's observation survey object, calculate the area ratio (%) that tongue fur covers, according to respondent's meansigma methods with following benchmark carry out ◎～* evaluation.

About using sense (taste), the oral mucosa zest, by respondent oneself evaluation, calculate the meansigma methods of scoring with following benchmark (7 grades), with following benchmark carry out ◎～* evaluation.

Tongue fur adheres to the metewand of inhibition;

◎ is more than 0, less than 15%

More than 0 15%, less than 30%

△ is more than 30%, less than 40%

More than * 40%

Use the metewand of sense (taste);

7 minutes complete imperceptible offending abnormal flavour

6 minutes imperceptible offending abnormal flavour almost

Within 5 minutes, not too feel offending abnormal flavour

Within 4 minutes, be difficult to estimate whether abnormal flavour is arranged

Within 3 minutes, feel slightly offending abnormal flavour

Within 2 minutes, obviously feel offending abnormal flavour

Within 1 minute, very obviously feel offending abnormal flavour

The irritating metewand of oral mucosa;

Complete imperceptible stimulation in 7 minutes

Almost imperceptible stimulation in 6 minutes

Within 5 minutes, not too feel stimulation

Within 4 minutes, be difficult to estimate whether stimulation is arranged

Within 3 minutes, feel slightly stimulation

Within 2 minutes, obviously feel stimulation

Within 1 minute, very obviously feel stimulation

Calculate above-mentioned each and estimate the meansigma methods of scoring, judge with following scoring benchmark.

◎ is more than 6 minutes

More than 0 4.5 minutes, less than 6 minutes

△ is more than 3.5 minutes, less than 4.5 minutes

* less than 3.5 minutes

[table 1]

[table 2]

[table 3]

[table 4]

[embodiment 19～31]

With the composition for oral cavity formed shown in above-mentioned same method for making modulomenter 5～7.Embodiment 19～23 is filled in automiser spray same as described above, embodiment 24～28 is filled into the agent container that drips, and (day, flourish Resin Industry Co., Ltd. manufactured, elite series DE20, material: polyethylene, 20mL), embodiment 29～31 is filled into the collutory container, and (Yoshino Kogyosho Co., Ltd manufactures, polyethylene terephthalate system, 250mL), according to above-mentioned evaluation methodology, estimated.

In addition, about the agent of dripping, use with above-mentioned tongue fur and adhere to after method that situation that inhibition estimates is identical removes tongue fur, use to the method for 3 of dripping on tongue and use the agent of dripping.In addition, about collutory, after similarly removing tongue fur, the method spued after gargling approximately 30 seconds with about 10mL is used collutory.With said method, estimated, result is as shown in table 5～7.

[table 5]

Spray

[table 6]

The agent of dripping

[table 7]

Collutory

In addition, use being described in detail as follows of raw material described.

Caprylin: Taiyo Kagaku Co., Ltd. manufactures, trade name Sunsoft700P-2

Caprin: Taiyo Kagaku Co., Ltd. manufactures, Sunsoft760

The endecatylene acid glyceride: Nikko Chemicals Co., Ltd manufactures, trade name NIKKOL MGU

Glyceryl laurate ester: Taiyo Kagaku Co., Ltd. manufactures, trade name Sunsoft750

Tripalmitin: Japanese latex (エ マ Le ジ ヨ Application) Co., Ltd. manufactures, trade name GMS-P

Polyglutamic acid sodium: Mingzhi's food materials (Off one De マ テ リ ア) Co., Ltd. manufactures, trade name Mingzhi's polyglutamic acid, and viscosity is as remembered in table.

Polyglutamic acid potassium: Mingzhi's food materials (Off one De マ テ リ ア) Co., Ltd. manufactures, and viscosity is as remembered in table.

Tetrasodium pyrophosphate: peaceful chemical Industry Co., Ltd manufactures.

In addition, the spice A～F of use is as shown in table 8～14.

[table 8]

Spice

Composition (%)	Spice A	Spice B	Spice C	Spice D	Spice E	Spice F
							Oleum menthae	25	20	10	8	0	5
Oleum menthae slips before removing 20% minute	25	25	10	8	10	10
							Film is processed the Oleum menthae of removing 15% terpenes part	0	0	10	0	5	20
Spearmint oil	1	5	1	0	0	1
							After slipping before removing 15% minute, spearmint oil slips minute	10	0	5	1	2	1
Japanese peppermint oil	1	1	0	20	0	1
							Japanese peppermint oil slips before removing 30% minute	1	1	10	10	2	4
Carvone	0	1	0	7	1	5
							Linalool	1	1	1	0	1	1
1, 8-Cineole	1	1	1	1	10	1
							Menthofuran	1	1	0	2	0	0
Camphora	1	1	1	1	1	0
							Menthone	1	1	1	0	1	0
Eugenol	1	1	1	1	1	2
							Menthyl acetate	1	0	0	1	1	1
Methyl salicylate	5	1	1	1	0	10
							Mediation spice 1 (table 9)	0.5	0	05	5	0.5	0
Mediation spice-2 (table 10)	1	0	1	10	1	0
							Mediation spice-3 (table 11)	1	0	1	1	1	0
Mediation spice 4 (table 12)	1	0	1	0.1	10	0
							Mediation spice 5 (table 13)	05	0	0.5	0.5	0.1	0
Mediation spice-6 (table 14)	1	0	1	1	1	0
							Propylene glycol	20	40	43	21.4	51.4	38
Add up to	100	100	100	100	100	100

[table 9]

The spice 1 that is in harmonious proportion forms

Fructus Citri Limoniae oil	1 part
		Fructus Citri Limoniae oil slips before removing 95% minute	1 part
Lime oil	1 part
		Mandarin oil	1 part
Grapefruit	1 part
		Oran Fructus Citri grandis oil	1 part
Grape-fruit seed oil	1 part
		Citral	1 part
Glyceryl triacetate	2 parts
		Add up to	10 parts

In table, part is mass parts (lower same).[table 10]

The spice 2 that is in harmonious proportion forms

Eucalyptus oil	1 part
		Oleum Caryophylli	1 part
Thyme oil	1 part
		Sage oil	1 part
Cardamom oil	1 part
		Fructus Coriandri oil	1 part
Oil of rosemary	1 part
		Laurel fat	1 part
Flos Matricariae chamomillae oil	1 part
		Caraway oil	1 part
Basil oil	1 part
		Propylene glycol	1 part
Add up to	12 parts

[table 11]

The spice 3 that is in harmonious proportion forms

Wintergreen oil	1 part
		Olibanum oil	1 part
Oleum lavandula angustifolia	1 part
		Orange blossom oil	1 part
Citronella oil	1 part
		The Rong Li caul-fat	1 part
Oleum Rosae Rugosae	1 part
		Rose absolute	1 part
The Rhizoma et radix valerianae absolute oil	1 part
		The Fructus Mangifera Indicae absolute oil	1 part
The dovetail flower concrete	1 part
		Orange Blossom	1 part
Propylene glycol	1 part
		Add up to	13 parts

[table 12]

The spice 4 that is in harmonious proportion forms

Menthyl lactate	1 part
		The N-replacement-to terpane-3-Methanamide	1 part
3-L-menthoxypropane-1, the 2-glycol	1 part
		The Herba Menthae glycerin ether	1 part
Affinin	1 part
		The mono succinate menthyl ester	1 part
Linalool oxide	1 part
		The vanillin butyl ether	1 part
Isopulegol	1 part
		Fructus Capsici extract	1 part
Ginger oil resin	1 part
		Pepper oleoresin	1 part
Capsicum oleoresin	1 part
		Propylene glycol	1 part
Add up to	14 parts

[table 13]

The spice 5 that is in harmonious proportion forms

Maltol	1 part
		Ethyl maltol	1 part
Vanillin	1 part
		Ethyl vanillin	1 part
Furanone	1 part
		Ethylcyclopentenolone	1 part
Methyl cyclopentenyl ketone	1 part
		2-Methyl Butyric Acid	1 part
Propanoic acid	1 part
		P-met hoxycinnamic aldehyde	1 part
Propylene glycol	1 part
		Add up to	11 parts

[table 14]

The spice 6 that is in harmonious proportion forms

Cis-3-hexenol	1 part
		Trans-2-hexenoic aldehyde	1 part
Ethyl n-butyrate.	1 part
		11 carbon lactones	1 part
Decalactone	1 part
		Isoamyl acetate	1 part
Benzaldehyde	1 part
		Exceed 600	1 part
The Ethyl-2-Methyl butyl ester	1 part
		Benzylalcohol	1 part
Alpha-terpineol	1 part
		Linalyl acetate	1 part
Ethyl phenylglycidate	1 part
		Phenethyl alcohol	1 part
Allyl hexanoate	1 part
		Capryl alcohol	1 part
Methyl cinnamate	1 part
		The heptyl carboxylate methyl ester	1 part
Ionoionone	1 part
		Ethyl-Beta-methyl thiopropionate	1 part
Cis-6-nonenol	1 part
		Watermelon ketone	1 part
Methyl jasmonate	1 part
		Propylene glycol	1 part
Add up to	24 parts

Claims (6)

1. a liquid or liquid composition for oral cavity, it is characterized in that, contain: the fatty acid glyceride that (A) carbon number of fatty acid is 8～14 and (B) polyglutamate, and (B) mass ratio of the composition of composition/(A) in 0.1～150 scope.

2. composition for oral cavity as claimed in claim 1, the fatty acid glyceride that the carbon number that its (A) composition is fatty acid is 8～11.

3. composition for oral cavity as claimed in claim 1 or 2, the proportional quantity of its (A) composition is 0.01～2 quality %.

4. as claim 1,2 or 3 described composition for oral cavity, the proportional quantity of its (B) composition is 0.05～5 quality %.

5. as any 1 described composition for oral cavity in claim 1 to 4, it is by the oral cavity internal spraying or drip, or gargles in oral cavity, is applicable to the composition for oral cavity on tongue surface.

6. a tongue fur attachment inhibitor, is characterized in that, the fatty acid glyceride that the carbon number that contains (A) fatty acid is 8～14 and (B) polyglutamate, and (B) mass ratio of the composition of composition/(A) is in 0.1～150 scope.