JP6529158B2 - Aerosol-type interdental cleaning composition - Google Patents

Description

  The present invention relates to an oral cavity cleaning composition of the aerosol type.

  As a method of removing dental plaque such as interdental teeth, there is a method of physically removing it with an interdental brush or a floss. However, technology is required to insert the interdental brush or floss into the interdental region, and if the gum is weak, the interdental brush or floss may damage the gum.

  Therefore, a method has been proposed in which plaque or the like is removed and the inside of the oral cavity is simply cleaned by spraying a stock solution containing a bactericide etc. from the aerosol container to the teeth, between teeth, gums etc. (Patent Document 1) . In the method, an aerosol type oral cavity cleaning composition comprising a stock solution and a propellant for spraying the stock solution is used.

  A liquefied gas is generally used as a propellant for the aerosol type oral cavity cleaning composition. However, when the liquid composition containing liquefied gas is directly injected into the oral cavity, there is a problem that a specific irritating odor is generated. In addition, liquefied gas may cause numbness in the tongue, which may cause harm to the oral mucosa.

  Specifically, it has been proposed to use carbon dioxide or nitrogen as a propellant (Patent Documents 1 and 2). However, when carbon dioxide is directly injected into the oral cavity, a pungent odor is obtained, and the pH of the liquid composition to be sprayed tends to fall below 5.5 even if a pH adjuster is incorporated. Nitrogen is less likely to cause harmful effects on teeth, oral mucosa, gums and the like. However, when nitrogen is directly injected into the oral cavity, it has a pungent odor that is specific but milder than carbon dioxide etc., and may precipitate in the composition.

Japanese Patent Application Laid-Open No. 2002-104554 Unexamined-Japanese-Patent No. 5-345026

  The present invention is an aerosol-type oral cleaning composition for direct cleaning between the teeth by direct injection to the interdental space, and the irritating odor is suppressed, and the harmfulness to teeth, oral mucosa, gums, etc. is reduced. It is an object of the present invention to provide an aerosol type oral cavity cleaning composition in which the precipitation of oil is suppressed.

  The aerosol type oral cavity cleaning composition of the present invention comprises a stock solution and a propellant, and the stock solution comprises (A) component: either or both of cetyl pyridinium chloride and benzethonium chloride, and (B) component: The propellant contains either one or both of glycerin and propylene glycol, and the propellant contains (C) component: nitrogen and / or nitrous oxide.

It is preferable that content of the said (A) component in the said undiluted | stock solution is 0.001-0.1 mass%.
It is preferable that content of the said (B) component in the said undiluted | stock solution is 1-12 mass%.

  The aerosol type intraoral cleaning composition of the present invention is a composition for direct cleaning between the teeth and the like to clean the inside of the oral cavity simply, and the irritating odor is suppressed, and harm to teeth, oral mucosa, gums and the like. The properties are reduced and the precipitation of oli is suppressed.

  The aerosol-type oral cavity cleaning composition of the present invention (hereinafter simply referred to as "the oral cavity cleaning composition") comprises a stock solution comprising the (A) component and the (B) component, and a propellant comprising the (C) component. And a composition comprising

[Stock solution]
The stock solution contains (A) component and (B) component. By containing the component (A) and the component (B) in the stock solution, the irritating odor when the intraoral cleaning composition of the present invention is sprayed into the oral cavity is suppressed, and the precipitation of oli is suppressed.
In addition, undiluted | stock solution means all components other than the propellant contained in the intraoral washing | cleaning composition of this invention.

((A) ingredient)
The component (A) is either one or both of cetyl pyridinium chloride and benzethonium chloride. That is, the stock solution may contain either cetyl pyridinium chloride or benzethonium chloride as the component (A), or may contain both cetyl pyridinium chloride and benzethonium chloride.

  0.001-0.1 mass% is preferable, and, as for content of (A) component in a undiluted | stock solution, 0.005-0.05 mass% is more preferable. When the content of the component (A) is equal to or more than the lower limit value, the irritating odor becomes more difficult to feel when the intraoral cleaning composition is sprayed into the oral cavity, and the precipitation of oli is easily suppressed. If content of (A) component is below the said upper limit, the irritation | stimulation derived from (A) component becomes more difficult to feel, and precipitation of oli is also easy to be suppressed.

((B) ingredient)
Component (B) is either one or both of glycerin and propylene glycol. That is, the stock solution may contain either glycerin or propylene glycol as the component (B), or may contain both glycerin and propylene glycol.

  1-12 mass% is preferable, and, as for content of (B) component in a undiluted | stock solution, 2-10 mass% is more preferable. When the content of the component (B) is equal to or more than the lower limit value, the irritating odor becomes more difficult to feel when the intraoral cleaning composition is injected into the oral cavity, and the precipitation of oli is easily suppressed. If content of (B) component is below the said upper limit, the irritation | stimulation derived from (B) component becomes more difficult to feel, and corrosion of the inside of a container also becomes difficult to occur.

(solvent)
The stock solution preferably contains water as a solvent. As water, purified water is preferable. As a solvent, ethanol or the like may be used.

(Optional ingredient)
The stock solution may optionally contain, in addition to the components (A) and (B), optional components other than the component (A), the component (B) and the solvent. As an optional ingredient, what is usually used for a composition for mouth washing can be used, for example, the ingredient shown below is mentioned.

Bactericides such as chlorhexidine, triclosan, isopropylmethylphenol, zinc gluconate and zinc citrate (with the exception of cetyl pyridinium chloride and benzethonium chloride).
Anti-inflammatory agents such as tranexamic acid, glycyrrhizinic acid dipotassium salt, ε-aminocaproic acid, and an opium extract.
Calculus preventive agents such as condensed phosphates and ethanehydroxy diphosphonates.

Allantoin chlorohydroxyaluminium, vitamin C, lysozyme chloride, glycyrrhetinic acid and its salts, sodium chloride, astringent agents such as allantoin.
Hypersensitivity inhibitors such as potassium nitrate.
Tooth strengthening agents such as sodium fluoride, hexafluorosilicic acid and salts thereof.
Stain removal agents such as sodium polyphosphate and sodium metaphosphate.

Topical stimulants such as l-menthol, dl-menthol, peppermint oil and the like.
Local anesthetics such as dibucaine hydrochloride and ethyl aminobenzoate.
Tissue repair agents such as sodium copper chlorophyllin.
Anti-halitides such as parsley seed oil, green tea extract, furanoboid, chlorophyll and champignon extract.

Anionic surfactants such as alkyl sulfates (sodium lauryl sulfate, sodium myristyl sulfate and the like), sodium α-olefin sulfonate and the like.
Nonion surfactants such as polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, and glycerin fatty acid ester.
Amphoteric surfactants such as alkyl betaine surfactants, amine oxide surfactants, imidazolinium betaine surfactants and the like.

Sweeteners such as sodium saccharin, stevioside, stevia extract, glycyrrhizin, sucrose, glucose, dextrose, invert sugar, fructose, oligosaccharide, reduced starch syrup, aspartame and the like.
Preservatives such as sodium benzoate, parahydroxybenzoic acid ester (methyl paraben, ethyl paraben, butyl paraben etc.), ethylenediamine tetraacetate, benzalkonium chloride and the like.
Ascorbic acid and derivatives thereof, tocopherol and derivatives thereof, riboflavin, pyridoxine hydrochloride, cyanocobalamin, β-carotene, ergocalciferol, menadione, ubiquinone and other vitamins.

Natural flavors (eucalyptus oil, thyme oil, sage oil, basil oil, iris concrete, rose absolute, orange flower absolute, vanilla absolute, etc.), single item flavors (limonene, pinene, butanol, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl Flavors such as anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol etc., formulated flavors (strawberry flavor, apple flavor, melon flavor etc), flavor solvents (ethyl alcohol, triacetin, glycerin fatty acid ester etc), etc.
As the optional components, one type may be used alone, or two or more types may be used in combination.

  The preparation method of the stock solution is not particularly limited. For example, the stock solution can be prepared by adding the components (A) and (B) and optional components used as needed to a solvent such as purified water and stirring. .

[Propellant]
The propellant is a component for injecting the stock solution, and is packed with the stock solution as a compressed gas or a liquefied gas in the container. The term "compressed gas" means a gas which is compressed to a degree not liquefied at a commonly used temperature and whose pressure is equal to or higher than atmospheric pressure. By liquefied gas is meant a gas that is liquid at present and has a boiling point of 40 ° C. or less at atmospheric pressure, or a liquid whose boiling point at atmospheric pressure exceeds 40 ° C. is at or above its boiling point.
The propellant contains component (C).

((C) ingredient)
The component (C) is either one or both of nitrogen and nitrous oxide. That is, the propellant may contain only one of nitrogen and nitrous oxide as the component (C), and may contain both nitrogen and nitrous oxide.

  With respect to the intraoral cleaning composition of the present invention, the volume ratio of the stock solution to the propellant in the container (stock solution / propellant) is preferably 80/20 to 40/60, and more preferably 70/30 to 50/50. The greater the amount of propellant, the better the injectability. As the amount of undiluted solution increases, the masking effect of the (A) component and the (B) component is more easily exhibited, and the irritating odor is easily suppressed.

[PH]
5.5-8.0 are preferable and, as for pH at 25 degreeC of the intraoral washing | cleaning composition of this invention, pH 5.8-7.0 are more preferable. If pH is more than the said lower limit, it is easy to reduce harmfulness to a tooth, an oral mucosa, etc. When the pH is equal to or lower than the upper limit value, damage to the oral mucosa is easily reduced, the masking effect of the components (A) and (B) is easily exhibited, and the pungent odor is easily suppressed.

[how to use]
As a method of using the intraoral cleaning composition of the present invention, a method using an aerosol container capable of spraying the intraoral cleaning composition between teeth etc. may be mentioned.
The aerosol container is not particularly limited as long as it can spray the intraoral cleaning composition between teeth etc. For example, a container main body filled with the intraoral cleaning composition and the upper part of the container main body What has an injection part is mentioned.

The container body is not particularly limited, and for example, a known pressure-resistant container can be used.
The injection unit includes, for example, an injection nozzle mounted on the upper part of the container body, and a push button, and a mechanism for injecting the intraoral cleaning composition in the container body through the injection nozzle when the push button is depressed. And those having the The mechanism for injecting the intraoral cleaning composition can adopt a known mechanism commonly used for aerosol containers.

  The injection nozzle includes, for example, a nozzle main body portion extending upward from the upper portion of the container main body and having a tip end portion bent forward, and a nozzle tip end portion projecting from the tip end surface of the nozzle body portion. . In the injection nozzle, by applying the tip of the nozzle to a recess between teeth, it is possible to stably spray the intraoral cleaning composition between the teeth.

  In the aerosol container as described above, the container body is filled with the undiluted solution and the propellant, the tip of the nozzle is brought into contact with the dent between the teeth, and the intraoral cleaning composition is toothed through the jet nozzle by depressing the push button. In the meantime, the plaque and the like are removed.

In the intraoral cleaning composition of the present invention as described above, even if brushing using an abrasive is not performed, direct injection to the interdental space etc. removes dirt and dental plaque between teeth, thus simplifying the oral cavity. Can be cleaned.
Further, in the intraoral cleaning composition of the present invention, since the component (C) is used for the propellant, harmful effects on teeth, oral mucosa, gums and the like are reduced. Further, by combining the propellant containing the (C) component with the stock solution containing the (A) component and the (B) component, the irritating odor due to the propellant is suppressed, and the precipitation of oli is suppressed. There is.

Hereinafter, the present invention will be described in detail by way of examples, but the present invention is not limited by the following description.
[material]
Raw materials used in this example are shown below.

((A) ingredient)
A-1: cetyl pyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.).
A-2: benzethonium chloride (manufactured by Lonza Japan Co., Ltd.).

((B) ingredient)
B-1: Glycerin (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.).
B-2: Propylene glycol (manufactured by Asahi Glass Co., Ltd.).

(Optional ingredient)
Citric acid (manufactured by Komatsuya Co., Ltd.).
Sodium citrate: Sodium citrate (manufactured by Komatsuya Co., Ltd.).
EtOH: ethanol (manufactured by Japan Alcohol Sales Co., Ltd.).
Perfumes A to F: Perfumes shown in Tables 1 to 7. The "parts" in Tables 2 to 7 mean parts by mass.

(solvent)
purified water.

((C) ingredient)
C-1: Nitrogen (0.72 MPa, manufactured by Joto Nikko Co., Ltd.).
C-2: Nitrous oxide (0.72 MPa, manufactured by Toshokai Co., Ltd.).

((C ') component: comparison component)
C'-1: carbon dioxide (0.72 MPa, experimental gas "carbon dioxide", manufactured by Nakamura Science Industry Co., Ltd.).
C'-2: Liquefied gas (0.72 MPa, dimethyl ether (DME), manufactured by Osaka Liquefied Gas Co., Ltd.).

[Examples 1 to 17, Comparative Examples 1 to 4]
The component (A), the component (B) and the optional component (other than purified water) were sequentially added to the purified water at the ratio shown in Table 8 and Table 9 and stirred, and uniformly dissolved to prepare a stock solution. In addition, three one motor (BL1200, product made by HEIDON) was used for preparation of a undiluted | stock solution.
Then, the undiluted solution and the propellant were filled in the pressure resistant container so that the volume ratio of the undiluted solution to the propellant (undiluted solution / propellant) was as shown in Table 8 and Table 9, to prepare an intraoral cleaning composition .

[Stimulating odor evaluation]
Using an aerosol container, the irritating odor felt when the oral cavity cleaning composition immediately after preparation was sprayed between teeth was determined according to the following criteria. The judgment was performed by 10 healthy subjects, and the irritation odor was evaluated based on the following criteria based on their average value.
(Judgment criteria)
4: There is no pungent smell at all.
3: There is very little pungent odor.
2: Slightly irritating odor.
1: There is a pungent smell quite.
(Evaluation criteria)
◎: The average value is 3.5 points or more.
○: The average value is 3.0 or more and less than 3.5.
Δ: The average value is 2.0 points or more and less than 3.0 points.
X: The average value is less than 2.0 points.

[Externality evaluation for gingiva]
Using an aerosol container, the sensation of irritation on the gums when spraying the freshly prepared oral cleaning composition between teeth was determined according to the following criteria. The evaluation was performed by 10 subjects who were sensitive to the oral mucosa, and the externality to gingival was evaluated based on the following criteria based on their average value.
(Judgment criteria)
4: There is no feeling of irritation at all.
3: There is a slight sense of irritation.
2: Slightly irritating.
1: There is a feeling of stimulation quite.
(Judgment criteria)
◎: The average value is 3.5 points or more.
○: The average value is 3.0 or more and less than 3.5.
Δ: The average value is 2.0 points or more and less than 3.0 points.
X: The average value is less than 2.0 points.

[Ori precipitation evaluation]
The oral cleaning composition immediately after preparation is filled in 80 mL of a clear PET container filled with 80 mL, stored at 5 ° C. for 1 month, then returned to room temperature and gently displaced according to the following criteria. It evaluated visually.
(Evaluation criteria)
:: There is no ORI at all.
○: There is very little oli.
:: There is a little.
X: There is quite a lot.

Tables 8 and 9 show the compositions of the intraoral cleaning compositions of Examples and Comparative Examples, and the evaluation results.
In addition, the "balance" of content of the purified water in Table 8 and Table 9 is an amount required to make it 100 mass% in the whole undiluted | stock solution. The column of propellant shows the proportion (volume%) of the component (C) or the component (C'-1) in the propellant.

As shown in Tables 8 and 9, in the oral cavity cleaning compositions of Examples 1 to 17 containing the stock solutions containing the (A) component and the (B) component and the propellant containing the (C) component, the pungent odor In addition to the reduction of the damage to the gums, the deposition of oli was also suppressed.
In the intraoral cleaning compositions of Comparative Examples 1 and 2 which do not contain either the component (A) or the component (B), the deposition of the pungent odor and odor was not sufficiently suppressed.
In the oral cavity cleaning composition of Comparative Example 3 in which carbon dioxide was used instead of the component (C) as the propellant, the pungent odor was not sufficiently suppressed.
In the oral cavity cleaning composition of Comparative Example 4 in which liquefied gas (DME) was used instead of the component (C) as the propellant, the irritating odor was not sufficiently suppressed and the harm to the gum was not sufficiently reduced. .

Claims (1)

Contains undiluted solution and propellant
The stock solution contains (A) component: either or both of cetyl pyridinium chloride and benzethonium chloride, and (B) component: either or both of glycerin and propylene glycol,
Content of the said (A) component in the said undiluted | stock solution is 0.001-0.1 mass%,
Content of the said (B) component in the said undiluted | stock solution is 1-12 mass%,
The aerosol-type interdental cleaning composition according to claim 1, wherein the propellant is component (C): one or both of nitrogen and nitrous oxide and used by direct injection between teeth .