JP5769939B2 - Composition for treating hypersensitivity of teeth - Google Patents

Description

  The present invention relates to a composition for treating hypersensitivity of teeth that has an affinity for dentin and that effectively closes open dentinal tubules.

  Many people suffer from hypersensitive teeth, a disease often referred to as dentine hypersensitivity and a common problem in the adult population. This is defined as transient pain that occurs in exposed dentin in response to chemical, thermal, tactile or osmotic stimuli that cannot be explained by any other dental defect or dental pathology . Erosion and / or gingival retraction of the outer surface of the tooth (enamel) often leads to exposure of the dentinal tubules, providing a pathway from the oral cavity to the intramedullary nerve fibers. It has been shown in vivo that a pressure gradient exists across the dentin, which causes fluid flow to the outside. This fluid flow is perturbed or increased in response to tactile, thermal (warm or cold) and osmotic pressure stimuli (such as high sugar concentrations), resulting in a mechanical stimulating receptor response in the gingival nerve fibers. This is thought to be a pain. Neural desensitizers and dentinal tubule closure agents have been used to treat dental hypersensitivity. Special toothpastes containing potassium nitrate and / or biograss, amorphous calcium phosphate, etc. are commonly used by consumers suffering from dentin hypersensitivity. Another occlusive agent that is also used to treat dental hypersensitivity is potassium oxalate. However, since the effective closure of dentinal tubules depends on various factors, none of these occlusive agents are completely effective in reducing dentin hypersensitivity. Therefore, a need continues to exist for dental hypersensitivity treatment compositions that have improved affinity for dentin and that effectively close the dentinal tubules.

The aforementioned objectives can be achieved by selecting a special composition that reduces tooth sensitivity by providing a dental protection barrier and / or effectively closing exposed dentin tubules. It's been found. In some embodiments, the present invention provides an oral composition comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids],
b) flavoring, if desired,
c) optionally sweetener d) optionally pH buffering agent, and
e) at least one orally acceptable solvent,
The oral composition provides an oral composition having a pH greater than 2.0 (or about 2) (or at least 2).

In other embodiments, the composition of the present invention is in an oral composition,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to dibasic acids C _6, are selected from the group consisting of tribasic and tetrabasic acids, and,
b) containing at least one orally acceptable solvent,
The composition relates to an oral composition that is substantially free of water.

In yet another embodiment, the composition of the present invention is an oral composition comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids],
b) at least one additional desensitizer, and
c) An oral composition comprising at least one orally acceptable solvent.

In another embodiment, the composition of the present invention comprises the step of applying the composition to the teeth at least twice in succession in a method of treating sensory sensitive teeth, the composition comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to dibasic acids C _6, are selected from the group consisting of tribasic and tetrabasic acids, and,
b) containing at least one orally acceptable solvent,
The interval between applications does not exceed 12 hours (or about 12 hours) (or less than 12 hours).

In yet another embodiment, the composition of the present invention relates to a method for closing a dentin tubule of a tooth, comprising the step of applying the composition to the tooth at least twice in succession, the composition comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth with the composition for at least 10 seconds (or about 10 seconds) (or more than 10 seconds);
Closing the tubules at least about 5% (or more than about 5%).

In yet another embodiment, the composition of the present invention comprises the step of applying the composition to the tooth at least twice consecutively in a method for closing a dental dentinal tubule, the composition comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth with the composition in the presence of calcium for at least 20 seconds,
The compound forms a precipitate on or near the teeth with calcium, so that after sonication for 2 minutes (or about 2 minutes), at least 30% (or about 30%) of the formed precipitate (or (> 30% precipitate) remains on the teeth.

In yet another embodiment, the composition of the present invention applies the composition to the teeth at least twice consecutively in a method of depositing a deposit on the teeth and / or on the dentin tubules of the teeth. The process comprising:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth to the composition in the presence of calcium for at least 20 seconds (or about 20 seconds) (or more than 20 seconds);
M ² is present in the precipitate at a concentration of at least 5% of the deposited precipitate (or about 5%) (or more than 5%).

Scanning electron microscope image of etched dentin pieces taken after 7 treatments with 0.5% potassium oxalate formulation. Fig. 5 shows a minimum amount of oxalate precipitate and / or dentinal tubule closure on the surface of the dentin strip after treatment. Scanning electron microscope image of etched dentin pieces taken after 14 treatments with 0.5% potassium oxalate formulation. Fig. 5 shows a minimum amount of oxalate precipitate and / or dentinal tubule closure on the surface of the dentin strip after treatment. Scanning electron microscope image of etched dentin pieces taken after 21 treatments with 0.5% potassium oxalate formulation. Fig. 5 shows a minimum amount of oxalate precipitate and / or dentinal tubule closure on the surface of the dentin strip after treatment. Scanning electron microscope image of etched dentin pieces taken after 28 treatments with 0.5% potassium oxalate formulation. Fig. 5 shows a minimum amount of oxalate precipitate and / or dentinal tubule closure on the surface of the dentin strip after treatment. Scanning electron microscope image of etched dentin pieces taken after 7 treatments with 0.5% potassium potassium oxalate preparation. It shows significant titanium oxide oxalate deposits and / or virtually complete dentin tubule closure on the surface of the dentin piece after treatment. Scanning electron microscope image of etched dentin pieces taken after 14 treatments with 0.5% potassium potassium oxalate preparation. It shows significant titanium oxide oxalate deposits and / or virtually complete dentin tubule closure on the surface of the dentin piece after treatment. Scanning electron microscope image of etched dentin pieces taken after 21 treatments with 0.5% potassium potassium oxalate preparation. It shows significant titanium oxide oxalate deposits and / or virtually complete dentin tubule closure on the surface of the dentin piece after treatment. Scanning electron microscope image of etched dentin pieces taken after 28 treatments with 0.5% potassium titanium oxalate preparation. It shows significant titanium oxide oxalate deposits and / or virtually complete dentin tubule closure on the surface of the dentin piece after treatment. Scanned version of etched dentin pieces prior to treatment with a formulation having the same components as those used for treatment of the dentin pieces of FIGS. 1-8, but not containing potassium oxalate or potassium titanium oxalate. Electron microscope image. It shows that there is no change in the sediment and / or dentinal tubule closure on the surface of the dentin pieces before and after treatment. Etched, taken after 28 treatments with a formulation having the same ingredients as those used to treat the dentin pieces of FIGS. 1-8, but not containing potassium oxalate or potassium titanium oxalate Scanning electron microscope image of a dentin piece. It shows that there is no change in the sediment and / or dentinal tubule closure on the surface of the dentin pieces before and after treatment. Scanned type of etched dentin pieces, treated 28 times with a formulation containing 0.5% potassium oxalate (Formulation B) and then sonicated for 2 minutes using a sonicator with normal pulses Electron microscope image. Etched dentinal pieces treated with a formulation containing 0.5% potassium potassium oxalate (formulation D) 28 times and then sonicated for 2 minutes using a sonicator with normal pulses. Scanning electron microscope image. Comparison of the images of these dentin pieces in FIGS. 11 and 12 with their corresponding 28-day treatment images shown in FIGS. 4 and 8 shows the stability of the precipitate produced by the potassium titanium oxalate formulation. It is shown that the property is improved compared to the stability of the precipitate by the potassium oxalate preparation.

  Compositions of the present invention comprise and consist of the essential elements and limitations of the invention described herein, as well as any additional or optional ingredients, components, or restrictions described herein, Or can consist essentially of these.

  All documents incorporated herein by reference in their entirety are only incorporated to the extent they do not contradict this specification.

  All percentages, parts and ratios are based on the total weight of the composition of the present invention unless otherwise specified. All such weights associated with the listed ingredients are based on activity levels and thus do not include carriers or by-products that may be included in commercially available materials unless otherwise specified.

  As used herein, the term “safe and effective amount” means within a suitable judgment range of one of ordinary skill in the art sufficient local or significant enough to cause obvious benefits, such as tooth desensitization. By an amount of a compound or composition that is system active but sufficiently small to avoid serious side effects, ie, provide a reasonable benefit-to-risk ratio.

  As used herein, the term “closed” or “closed” means that the exposed opening of or into the dentinal tubule is partially, substantially, or completely occluded. Means.

The composition according to the invention comprises at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are independently a monovalent or divalent metal, M ² is a polyvalent metal or a metal oxide thereof, and A and B are independently C ₂ dibasic acids -C _6, tribasic and tetrabasic acids, optionally diacid or triacid of C ₂ -C _4, optionally diacid or triacid of C ₂ -C ₃ or optionally, Selected from the group consisting of C ₂ dibasic acids.

  Examples of suitable monovalent metals include, but are not limited to Na, K and Li, optionally Na or K, or optionally K.

  Examples of suitable divalent metals include, but are not limited to Mg, Ca, Sr, Ba, and Zn, optionally Mg, Ba and Zn, or optionally Mg.

  Examples of suitable multivalent metals include Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Tc, Re, Os, Ir, Hg, Ce, Sn, Eu, Yb, Pa and U, as desired Ti, Sn, Mn, and Fe, or Ti if desired, are not limited to these.

  Examples of suitable metal oxides include Ba, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Tc, Re, Os, Ir, Hg, Ce, Sm, Eu, Yb, Pa and U. Corresponding oxides, optionally corresponding oxides of Ba, Ti, Sr, Sn, Zr, Mn and Fe, optionally corresponding oxides of Ba, Ti, Sr, Sn, Zr, or optionally corresponding to Ti Although an oxide is mentioned, it is not limited to these.

In some embodiments, M ¹ and / or M ³ are independently selected from the group consisting of Na, K, and Li. Optionally, both M ¹ and M ³ are K.

In some embodiments, ^{M 2} is Ti, Sr, Sn, Mg, Ca, is selected from the group consisting of Mn and Zr. Optionally, ^{M 2} is Ti, Sr, Sn, Mg, Ca, is selected from the group consisting of oxides of Mn and Zr. In other embodiments, M ² is selected from the group consisting of Ti or an oxide of Ti.

  Examples of suitable dibasic acids include oxalic acid, succinic acid, methyl succinic acid, diglycolic acid, glutaric acid (ie pentanedioic acid), 3,5,5-trimethylpentanedioic acid, hexanedioic acid, 3,5 , 5-trimethylhexanedioic acid, 2,4,4-trimethylhexanedioic acid, decanedioic acid, undecanedioic acid, dodecanedioic acid, 1,4-cyclohexanedicarboxylic acid, cyclohexane-1,4-diacetic acid, maleic acid Citraconic acid, itaconic acid, fumaric acid, oxalic acid, terephthalic acid, phthalic acid and isophthalic acid, hydroxysuccinic acid, malonic acid, adipic acid, sebacic acid and tartaric acid, optionally oxalic acid, succinic acid, or optionally oxalic acid However, it is not limited to these.

  An example of a suitable tribasic acid includes, but is not limited to, citric acid.

  Examples of suitable tetrabasic acids include 1,1,2,2-ethanetetracarboxylic acid, 1,1,2,3-propanetetracarboxylic acid, 1,1,4,4-butanetetracarboxylic acid, , 2,4,5-benzenetricarboxylic acid and ethylenediaminetetraacetic acid, or optionally 1,1,2,2-ethanetetracarboxylic acid, but are not limited thereto.

  In some embodiments, the compound of formula I comprises potassium potassium oxalate oxide (“KTO”) (also referred to as titanium potassium oxalate), titanium potassium citrate oxide, calcium calcium oxalate and potassium calcium oxalate. , Optionally selected from the group consisting of potassium potassium oxalate oxide (“KTO”), oxidized potassium potassium citrate, or optionally oxidized potassium potassium oxalate (“KTO”).

  Compositions of the present invention may be from 0.01% (or about 0.01%) to 10.0% (or about 10.0%), optionally 0.1% (or, based on the total weight of the composition) At least one of about 0.1%) to 7.0% (or about 7.0%), or optionally 1% (or about 1%) to 5.0% (or about 5.0%), Including compounds of formula I.

  In some embodiments, the composition of the present invention includes a solvent that is acceptable in the oral cavity. Solvents acceptable in the oral cavity include, but are not limited to: water; ethanol; n-propanol; or polyhydric alcohols such as glycerin, sorbitol and polyethylene glycol; and any mixtures thereof. Also, the oral acceptable solvent may be present at a concentration of about 0.1% to about 99.9%, optionally about 1% to about 90%, or optionally about 10% to about 75%.

  In some other embodiments, the composition of the present invention is substantially free of water. As used herein, “substantially free” means less than 5% (or about 5%), optionally less than 3% (or about 3%), optionally 1% (or about 1%). Less than, optionally less than 0.5% (or about 0.5%), optionally zero (or anhydrous).

  In some embodiments, the composition of the present invention has at least 2 (or about 2), optionally 2.5 (or about 2.5) to 7.0 (or about 7.0), optionally 3. It has a pH of 5 (or about 3.5) to 6.0 (or about 6.0), or optionally 3.2 (or about 3.2) to 4.5 (or about 4.5).

  In some embodiments, the pH of the compositions of the present invention may be buffered using conventional acid / salt systems. Usual buffer systems include phosphoric acid and sodium phosphate salt, or citric acid and sodium citrate salt. Suitable acid / acid salt buffer combinations for use in the present invention include up to about 1% by weight of the composition, optionally from about 0.05% to about 0.75% by weight of the composition, and / or optionally. Citric acid-sodium citrate, phosphoric acid-sodium phosphate, monobasic sodium phosphate, dibasic sodium phosphate, acetic acid-sodium acetate in an amount from about 0.1% to about 0.5% by weight of the composition Succinic acid-sodium succinate, aconitic acid-sodium aconitic acid and benzoic acid-sodium benzoate.

Optional In some embodiments, the composition of the present invention further comprises other dental desensitizers. Examples of additional tooth desensitizers include, but are not limited to, potassium citrate, potassium chloride, potassium nitrate, citric acid, citrate, strontium chloride and mixtures thereof. Further, the bioactive glass materials described in U.S. Pat. Nos. 5,359,942, 5,891,233, 6,086,374, 6,244,871, 6,338,751, and 6,365,132 are useful herein and are incorporated herein in their entirety. This is incorporated herein by reference. Also useful herein are phosphopeptides described in US Pat. Nos. 5,015,628, 5,981,475, 6,448,374, and 6,780,844, the entire contents of each of which are hereby incorporated by reference.

  In some embodiments, the additional tooth desensitizer is potassium nitrate. In some embodiments, the concentration of the additional tooth desensitizer is from 0.1% (or about 0.01%) to 10% (or about 10%), optionally 0, of the composition. From 1 wt% (or about 0.1 wt%) to 8 wt% (or about 8 wt%), or optionally 1 wt% (or about 1 wt%) to 7 wt% (or about 7 wt%) is there.

  It is well known that fluoride ion sources are used in oral care compositions as caries preventive actives, which may also be incorporated into the compositions of the present invention. Fluoride ions are included in many oral care compositions, particularly toothpastes, for this purpose. Patents disclosing such toothpastes include U.S. Pat. Nos. 3,538,230, 3,688,637, 3,711,604, 3,911,104, 3,935,306, and 4,040,858, the entire contents of which are incorporated herein. Incorporated by reference.

  Application of fluoride ions to the tooth enamel serves to protect the tooth from caries. A wide variety of fluoride ion generating materials can be employed as the soluble fluoride source of the compositions of the present invention. Examples of suitable fluoride ion generating materials are US Pat. No. 3,535,421 issued to Briner et al. Issued Oct. 20, 1970 and U.S. Pat. No. issued to Widder et al. Issued Jul. 18, 1972. 3,678,154, the entire contents of both patents are incorporated herein by reference. In some embodiments, the fluoride ion source used herein includes stannous fluoride, monofluorophosphate, sodium fluoride, potassium fluoride, and ammonium fluoride. In other embodiments, sodium fluoride is incorporated. In some embodiments, the composition of the present invention provides about 50 ppm to 10,000 ppm, optionally about 100 ppm to 3000 ppm of fluoride ions in an aqueous solution that contacts the tooth surface.

Phosphate is also useful in the compositions of the present invention. Phosphate includes pyrophosphate, polyphosphate, polyphosphonate and mixtures thereof. Pyrophosphate is best known for use in dental care products. Pyrophosphate ions derived from pyrophosphate are delivered to the teeth. Pyrophosphates useful in the compositions of the present invention include dialkali metal pyrophosphates, tetraalkali metal pyrophosphates and mixtures thereof. Non-hydrated and disodium dihydrogen pyrophosphate (Na ₂ H ₂ P ₂ O ₇ ), tetrasodium pyrophosphate (Na ₄ P ₂ O ₇ ) and tetrapotassium pyrophosphate (K ₄ P ₂ O ₇₎ ) Is a preferred species. In some embodiments, the pyrophosphate is tetrasodium pyrophosphate.

  Pyrophosphate is described in more detail in Kirk & Othmer, Encyclopedia of Clinical Technology Third Edition, Volume 17, Wiley-lnterscience Publishers (1982), and in detail. Is incorporated herein by reference. Additional anticalculus agents include pyroacrylates or polyphosphates disclosed in US Pat. No. 4,590066; polyacrylates such as those disclosed in US Pat. Nos. 3,429,963, 4,304,766 and 4,661,341. Other polycarboxylates; polyepoxysuccinates such as those disclosed in US Pat. No. 4,846,650; ethylenediaminetetraacetic acid disclosed in British Patent No. 490,384, Feb. 15, 1937; US Pat. Nitrilotriacetic acid and related compounds disclosed in US Pat. No. 3,678,154; polyphosphonates disclosed in US Pat. Nos. 3,737,533, 3,888,443 and 4,877,603, all cited patents are hereby incorporated by reference in their entirety. Incorporated by reference into the book. In some embodiments, the phosphate includes potassium pyrophosphate and sodium pyrophosphate; sodium tripolyphosphate; ethane-1-hydroxy-1,1-diphosphonate, 1-azacycloheptane-1,1-diphosphonate And diphosphonates such as linear alkyl diphosphonates; tricalcium phosphate, linear carboxylic acid, sodium zinc citrate, and mixtures of any of the aforementioned phosphates. In some embodiments, the phosphate salt can be obtained from Karlinsey, Robert L., published August 7, 2008. U.S. Pat. No. 2,080,187,500 A1, tricalcium phosphate plus sodium lauryl sulfate, the disclosure of which is hereby incorporated by reference in its entirety.

  When incorporated into the compositions of the present invention, the phosphate is at a concentration of about 0.01% to about 10%, optionally about 0.1% to about 7%, and optionally about 0.5% to about 5%. Can exist.

  In some embodiments, the composition of the present invention also includes an essential oil. Essential oils are volatile aromatic oils that are obtained synthetically or by distillation, extrusion or extraction from plants. Essential oils usually have the scent or flavor of the plant from which they are obtained. Essential oils provide anti-gingivitis activity when used as a dentifrice composition of the present invention. Some of these essential oils also function as flavoring agents. Essential oils of the present invention include, but are not limited to, thymol, menthol, methyl salicylate (winter green oil) and eucalyptol.

  Thymol, also known as the chemical formula 5-methyl 2- (1-methylethyl) phenol, is obtained from the essential oils of Thymu svlgaris Labiatae and Monarda punctata Labiatae. Thymol is a white crystalline powder with aroma and flavor. Thymol is soluble in organic solvents, but only slightly soluble in deionized water.

  Menthol is isolated primarily from thin cargo oil. As a commercial product, menthol is available as crystals of L-menthol obtained by a process involving oil cooling. Peppermint oil fractionation, usually containing from about 40% to about 65% menthol, is another important source of menthol. A synthetic source for L-menthol is also available.

  Eucalyptol can be obtained from the eucalyptus tree. This essential oil with camphor odor and cool taste is often combined with other essential oils such as menthol in a confectionery formulation to provide a therapeutic effect. The combination of menthol and eucalyptol is widely used. Particularly preferred uses of the combination of menthol and eucalyptol include dentifrices such as toothpastes or dental gels according to the invention.

  Methyl salicylate is the main component of many essential oils, accounting for about 99% of winter green oil (Gaulteria procumbens) and sweet birch (Betula lenta). Methyl salicylate, which has a unique refreshing scent, is widely used in gargles, chewing gums and other oral and pharmaceutical products.

  The amount of essential oil that can be used in the composition of the present invention is 0.001 (or about 0.001) to 1% (or about 1%) thymol, 0.001 (or about 0.001) to 1% (or About 1%) methyl salicylate, 0.001 (or about 0.001) to 15% (or about 15%) menthol and 0.001 (or about 0.001) to 1% (or about 1%) Eucalyptol, and these amounts are clinically effective in preventing gingivitis. Optionally, the composition according to the invention contains about 0.064% thymol, about 0.060% methyl salicylate, about 0.042% menthol and about 0.092% eucalyptol, these amounts Is clinically effective in preventing gingivitis.

  Alternatively or in addition to the essential oils, the composition of the present invention comprises an antibacterial effective amount of a polyphenol (eg, triclosan) zinc salt, tin fluoride, chlorhexidine, hexetidine, sanguinarine, benzalkonium chloride, salicylanilide, bromide. Domifene, cetylpyridinium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC), octenidine, delmopinol, octapinol, and other piperidine derivatives, nicin preparations, zinc / tin ions Agents; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole, and analogs and salts thereof; eugenol, geraniol, carvacrol, sitler , Hinokitiol, essential oils, such as catechol; can include hydrogen peroxide, chlorite metal salt, or an antimicrobial agent selected from any of the group consisting of any combination of the above.

  Mixtures of any of the above agents can also be used.

  The compositions of the present invention can also contain a surfactant selected from anionic, nonionic, amphoteric, betaine, cationic surfactants, and mixtures thereof. Suitable anionic surfactants include alkyl sulfates, alkyl ether sulfates, sulfosuccinates, isethionates, acylamides, alkyl ether carboxylates and alkyl phosphates, where the alkyl group is about 6 carbons. Contains from about 30 carbon atoms. Suitable cationic surfactants include cetyl pyridinium chloride. The total amount of surfactant suitable for use in the compositions of the present invention is about 1% to about 50%, optionally about 5% to about 40%, or optionally about 8%, based on the total weight of the total composition. % To about 25%.

  Types of nonionic surfactants suitable for use in the present invention include aliphatic alcohol acids or amido ethoxylates, monoglyceride ethoxylates, sorbitan ester ethoxylates and alkyl polyglycosides. In the compositions of the present invention, these nonionic surfactants are from about 0.0% to about 30%, such as from about 0.1% to about 20% and from about 0.00%, based on the total weight of the composition. It can be used in an amount of 1% to about 15%.

  A class of amphoteric surfactants suitable for use in the present invention include alkyliminodiproprionates, alkylamphoglycinates (mono or di), alkylamphoproprionates (mono or di), alkylamphoacetates (mono or di). ), N-alkyl b-aminoproprionic acid, alkyl polyaminocarboxylates and phosphorylated imidazolines. In the compositions of the present invention, these amphoteric surfactants are about 0.1% to about 20%, such as about 0.1% to about 15% and about 0.1%, based on the total weight of the composition. Can be used in an amount of ~ 10%.

  Suitable types of betaines for use in the present invention include alkyl betaines, alkylamido betaines, alkyl sultaines and alkylamido sultaines, wherein the alkyl group has from about 6 carbon atoms to about 30 carbon atoms. And about 10 to 14 carbon atoms are preferred. In the compositions of the present invention, these betaine surfactants are about 0.1% to about 15%, such as about 0.1% to about 10% and about 0.1%, based on the total weight of the cleansing composition. % To about 8% can be used.

  Suitable classes of cationic surfactants for use in the present invention include alkyl quaternary compounds (mono, di or tri), benzyl quaternary compounds (eg cetylpyridinium chloride), ester quaternary compounds, ethoxylated quaternary compounds. Examples include compounds, alkylamines and mixtures thereof, where the alkyl group has from about 6 carbon atoms to about 30 carbon atoms, with about 8 to about 22 carbon atoms being preferred. In the compositions of the present invention, these cationic surfactants are about 0.01% to about 20%, optionally about 0.05% to about 15%, and / or optionally, based on the total weight of the composition. It can be used in an amount of about 0.1% to about 10%.

The compositions of the present invention can also include one or more optional ingredients, including thickeners, humectants, chelating agents, and additives such as flavoring agents, preservatives, and the like. Commercially available thickeners that can impart an appropriate viscosity to the composition can be suitably used in this invention. Examples of suitable thickeners include 1) a mono- or diester of polyethylene glycol of formula HO— (CH ₂ CH ₂ O) _z H, wherein z is an integer from about 3 to about 200, and 2) Fatty acids containing from about 16 to about 22 carbon atoms, fatty acid esters of ethoxylated polyols, ethoxylated derivatives of mono- and diesters of fatty acids and glycerol, hydroxyalkyl celluloses, alkyl celluloses, hydroxyalkylalkyl celluloses and mixtures thereof Listed exclusively. Preferred thickeners include polyethylene glycol esters, more preferably the Stepan Company in Northfield, Illinois, or Comiel, S., Bologna, Italy. p. A. PEG-150 distearate obtained under the trade name “PEG 6000 DS”.

  In some embodiments, thickeners are present in the compositions of the present invention from about 0.01% to about 10%, optionally from about 0.1 to about 5%, or optionally from about 0.2% to about 2 It can be included at a concentration of 0.0%.

Commercially available humectants, as detailed above, are suitable for use in the present invention because of their moisturizing properties in addition to potential solvent use. The humectant is present in an amount of about 0% to about 10%, preferably about 0.5% to about 5%, more preferably about 0.5% to about 3%, based on the total weight of the composition. be able to. Non-exclusive examples of suitable humectants include 1) water-soluble liquid polyols selected from the group comprising glycerin, propylene glycol, hexylene glycol, butylene glycol, dipropylene glycol and mixtures thereof, 2) Formula: HO -(R "O) _b -H polyalkylene glycol wherein R" is an alkylene group having from about 2 to about 3 carbon atoms and b is an integer from about 2 to about 10; 3) _{: CH 3 -C 6 H 10 O} 5 - (OCH 2 CH 2) [ wherein, c is from about 5 to about 25 integer] polyethylene glycol ether of methyl glucose of c -OH, 4) urea, and 5) thereof And glycerin is a preferred humectant.

  In some embodiments, the humectant is present in the composition of the present invention at a concentration of about 0.1% to about 40%, optionally about 1.0 to about 30%, or optionally about 5% to about 25%. Can be incorporated.

  In some embodiments, chelating agents can be incorporated into the compositions of the present invention. Examples of suitable chelating agents include chelating agents that can protect and preserve the compositions of the present invention. Tetrabasic acids may be used in the compounds of Formula I, but in addition ethylenediaminetetraacetic acid (“EDTA”) can be used as a chelating agent if desired. In some embodiments, the chelating agent is tetrasodium EDTA under the trade name “Versene 100XL” commercially available from Dow Chemical Company, Midland, Michigan, and is about 0 to about 0.5% of the total weight of the composition. And optionally in an amount from about 0.05% to about 0.25%.

  Suitable preservatives include sodium benzoate and polysorbate, from about 0 to about 0.2%, preferably from about 0.05% to about 0.00%, based on the total weight of the composition in the composition. Present in an amount of 10%.

  The composition of the present invention comprises a mouthwash, a mouthwash, a dentifrice, a paste such as a toothpaste, a powder such as a toothpaste, a gel, a tablet, a troche, a microcapsule, a spray, a varnish or a strip (herein in its entirety). The remineralized strip disclosed in US Patent Application Publication No. 20070128130 published June 7, 2007 to Kropt et al., Or both patent documents incorporated herein by reference in their entirety. Peroxides or non-peroxides disclosed in US Patent Application Publication No. 200800032448 published on Jan. 3, 2008 to Georgiades et al. And US Pat. No. 6,949,240 issued Sep. 27, 2005 to Sagel et al. Tooth bleaching strips etc.), such as coatings for these strips It can be a state. As suggested in the above description, the composition of the present invention is disclosed in US Patent Application Publication No. 20080044363 published on 21 February 2008 by Montgomery, which is hereby incorporated by reference in its entirety. It can also be applied by conventional oral care devices such as toothbrushes, dental picks, dental floss, dental sprayers or misters and dental pens.

  The composition of the present invention can also be used as a coating for dental tools selected from the group consisting of toothbrushes (manually or mechanically driven), toothbrush bristles, dental floss, dental picks, etc. or as an impregnating agent for impregnating them. Can be useful. The compositions of the present invention may also be useful as coatings for dental composite materials, dental fillers or as impregnating agents.

Methods of Use of the Compositions of the Invention The inventions disclosed herein can be practiced without any components, components or steps not expressly disclosed herein.

  In some embodiments, the composition of the present invention is applied to at least two consecutive hypersensitive teeth, optionally at least 7 (or about 7) (or more) consecutively, or optionally 14 (Or about 14) consecutively, or optionally 21 (or about 21) consecutively, or optionally 28 (or about 28) consecutively.

  When applied to the hypersensitive tooth (s), in some embodiments, the composition is applied to the hypersensitive tooth for at least 10 (or about 10) seconds (or more), optionally 20 (or more). Leave in contact for about 20) seconds, optionally 30 (or about 30) seconds, optionally 50 (or about 50) seconds, optionally 60 (or about 60) seconds.

  In some embodiments, the time interval between successive applications does not exceed 12 (or about 12) hours (or less), optionally 8 (or about 8) hours, optionally 4 (or about 4). The time should be 2 (or about 2) hours, optionally 1 (or about 1) hours, if desired.

  In some embodiments, the composition of the present invention closes at least 5% (or about 5%) (or more) of the dental dentinal tubules with the available calcium of the compound of Formula I. Optionally, 25% (or about 25%) of the dentinal tubules are closed, optionally 40% (or about 40%) of the dentinal tubules are closed, optionally 60% (or about 40%) of the dentinal tubules 60%) is closed, optionally 75% (or about 75%) of the dentinal tubules are closed, optionally 85% (or about 85%) of the dentinal tubules are closed, optionally dentin It is applied to perceptually sensitive teeth so as to form a deposited deposit on the teeth such that 95% (or about 95%) of the tubules are closed.

In some embodiments, M ² of formula I is at least 5% (or about 5%) (or more), optionally 10% (or more) in the precipitate deposit formed from the compound of formula I and calcium. Or about 10%), optionally 20% (or about k20%), or optionally 35% (or about 35%).

  Once formed on the teeth, the stability provided by precipitate deposits comprising a compound of formula I and calcium is the best and more electronics of China, Best And More Electronics [Shenzhen] Co. , Ltd., Ltd. Was sonicated with a normal pulse of about 42 KHzt for 2 (or about 2) minutes using a sonicator CD-4800 (Digital Professional Ultrasonic Cleaner [CD-4800]) manufactured by About 5%) (or more), optionally 30% (or about 30%), optionally 35% (or about 35%), optionally 50% (or about 50%), optionally 75% (or About 75%), or optionally 90% (or about 90%) remains on the teeth. At this pulse, the sonicator typically provides a stronger force than is normally used for sonic or hand brushing. As used herein, the term “precipitate deposit” refers to the precipitation of a compound of formula I and calcium present in fluids in the oral cavity after applying a composition comprising a compound of formula I disclosed in this application. It means deposits generated on the teeth by the objects and / or deposits that close the tubules of the teeth. The addition of calcium as a water-soluble calcium salt separately into the oral cavity before or after the addition of the composition of the invention comprising a compound of formula I also generates or accelerates the formation of a precipitate deposit by the compound of formula I. The Suitable water soluble calcium salts include, but are not limited to, calcium chloride, calcium nitrate, calcium bromide, calcium dihydrogen phosphate, and mixtures thereof. The amount of water-soluble calcium salt should exceed the amount of compound of formula I provided by the composition of the present invention on a molar basis.

  Several examples are given below to further illustrate the nature of the invention and how it is practiced.

  The compositions of the present invention shown in the following examples represent specific embodiments of the compositions of the present invention and are not intended to limit the present invention. Other modifications can be made by those skilled in the art without departing from the spirit and scope of the invention.

Preparation of mouth washes A liquid mouth washes was prepared and the dentin closure efficiency of potassium potassium oxalate (KTO) formulations was evaluated. The preparation method is as follows.

  Water, KTO, benzoic acid and poloxamer were added to the formulation container and mixed until dissolved. When the poloxamer dissolved, alcohol, n-propanol, sorbitol and water were added, then sodium benzoate was added and mixed until dissolved. The pH was examined and determined to be about 4.2.

  Menthol, thymol, eucalyptol and methyl salicylate were added to the above formulation mixture and mixed until homogeneous. After a homogeneous solution was formed, sodium saccharin and FDC Green # 3 (1% solution, purity adjusted) were added. The formulation was mixed until homogeneous. The final pH of the formulation was 4.2.

The composition of the liquid mouth rinse preparation is shown in Table 1.

Preparation of dentin samples and artificial saliva The effectiveness of KTO compounds and the formulations of the present invention for dentin closure was demonstrated as follows.

  Dentin chips (polished and not etched) were obtained from Dental product testing, Division of Thermal technologies Inc. , Indianapolis, Indiana, USA. Dentin chips are soaked in 6% citric acid for a maximum of 2 minutes to completely remove the dirty layer (or debris layer produced by cutting dentin or enamel), then rinsed in deionized water Etching was performed by sonication.

  Potassium oxalate (KO) is available from Fluka, St. Obtained from Louis, MO, (lot #: 430462/1). Potassium titanium oxalate (KTO) dihydrate can be obtained from Sigma, St. Obtained from Louis MO (lot # 51740).

ｐＨ＝７．０ Artificial saliva was prepared to have the composition shown in Table 2 using conventional equipment and procedures commonly used in laboratory protocols.

pH = 7.0

Comparative Testing and Analysis All etched dentin samples (10 total) were randomized and divided into 5 treatment groups. Surface chemical analysis by scanning electron microscopy (SEM) and electron dispersive spectroscopy (EDS) was performed to observe capillary closure and surface deposition with the KTO formulation. The five treatment groups were as follows:
Group 1: Treated with Formulation A.
Group 2: Treated with formulation B.
Group 3: Treated with Formulation C.
Group 4: Treated with formulation D.
Group 5: Treated with Formulation E (ie, no KTO or KO).

The treatment plans for groups 1-5 consisted of:
1. A small sample of each group was treated with 20 mL of each treatment formulation with shaking for 30 seconds.
2. A small sample of each group was rinsed with deionized H ₂ O for 1 minute.
3. During the treatment, the small sample was immersed in the artificial saliva composition, and no treatment more than twice a day was performed.
4). The processes of steps 1 to 3 were repeated a total of 28 times.
After 5.7, 14, 21, and 28 treatments, the dentin samples were analyzed by SEM and / or EDS. Prior to analysis, the pieces were rinsed with deionized H ₂ O for 3 minutes, air dried and subjected to SEM analysis.

Data obtained from EDS analysis of two strip samples per group (Strips 1 and 2) are summarized in Tables 3 and 4 below.

  After 7 treatments, the sample treated with 0.5% KTO (formulation D) has a ratio of sulfur detected by EDS reading (the EDS spectrum on the etched dentin surface usually contains 45-50% sulfur). As can be seen from the decrease in (shown), it shows the highest affinity for the etched dentin surface. The percentage of sulfur detected is reduced because sulfur on the surface of the dentin pieces is covered or masked by surface deposits produced by treatment with the KTO formulation. Although not completely absent, in the sample treated with 0.1% KTO (Formulation C), the percentage of sulfur detected is dramatically reduced. After 14 treatments, the percentage of sulfur detected in the sample treated with 0.5% KTO (formulation D) remains low, and even more pronounced for the sample treated with 0.1% KTO (formulation C). It is falling.

  Scanning electron microscopy performed on these samples suggests the initiation or generation of surface precipitates on the dentin surface in the formulation D samples, and the extent of tubule closure increases with the number of treatments.

For semi-quantitative comparison of the efficacy of dentin tubule closure of different formulations, SEM analysis, image grading and tubule closure rate calculations were performed. Methods and calculations to obtain SEM data analysis, image grading and tubule closure rates are described in West NX, Addy, M, Hughes, J. et al. (1998) J. MoI. Oral Rehab, 25, 885, according to Lee SY, Kwon HK, Kim BI (2008) J. MoI. It was confirmed by the method described in Oral Rehab, 35,847. Based on the analysis of the SEM data described above, the tubule closure rates for 7, 14, 21 and 28 treatments of formulations AE were determined and summarized in Table 5.

  Comparative analysis data (Table 5 and FIGS. 1-4 (KO treatment), FIGS. 5-8 (KTO treatment)) before and after treatment (before treatment) and after treatment with different treatment cycle numbers and different KTO concentrations, and FIGS. Tables 9 and 10 (shown in Oxalate treatment)) clearly demonstrate an increase in surface sediment that results in an enhanced effective increase in capillary closure.

Measuring the persistence of the sediment deposit formed To measure the persistence of the KTO deposit deposited on the dentin strip sample during the processing cycle (ie, the ability of the deposit to remain on the tooth surface): went. Dentin pieces treated 28 times with Formulation B (0.5% KO) and Formulation D (0.5% KTO) using a sonicator CD-4800 with normal pulse (about 42 KHz) 2 Sonicated for minutes (may be about 2 minutes). Comparing the images of the sonicated pieces (FIGS. 11 and 12) with the corresponding 28-day processed images depicted in FIGS. 4 and 8, the sediments generated by KTO (generated by KTO) About 92% of the precipitate remained on the small piece sample) was more sonicated than the precipitate produced by KO (about 38% of the precipitate produced by KO remained on the small piece sample). It is highly resistant, indicating that the sediment deposited by KTO provides higher stability compared to the sediment deposited by KO. Without being limited by theory, this improved stability of the precipitate deposit produced by the compound of Formula I is not only for greater tooth desensitization, but also for longer period of tooth desensitization. It is thought that the work is also offered.

Tables 6 and 7 show examples FO illustrating examples of further gargles of the compositions of the present invention. Examples FO can be prepared by the methods outlined for Examples AE above.

Table 8 shows Examples PS that illustrate examples of toothpastes of the compositions of the present invention. Examples PS can be prepared by existing toothpaste mixing techniques. Example S illustrates an embodiment of the anhydrous toothpaste of the present invention.

Embodiment
(1) In the composition for oral cavity,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to dibasic acids C _6, are selected from the group consisting of tribasic and tetrabasic acids, and,
b) at least one orally acceptable solvent,
Including
The oral composition, wherein the oral composition has a pH of at least 2.0.
(2) The composition of embodiment 1, wherein the pH is from about 2.5 to about 7.0.
(3) The composition according to embodiment 1, wherein M ¹ and M ³ are each independently a monovalent metal selected from the group consisting of Na, K and Li.
(4) The composition according to embodiment 3, wherein M ¹ and M ³ are K.
(5) The composition according to embodiment 1, wherein M ² is a divalent metal selected from the group consisting of Ti, Sr, Sn, Mg, Ca, Mn and Zr.
(6) ^{M 2} is Ti, a composition according to claim 5.
(7) M ² is a metal oxide selected from the group consisting of barium oxide (Ba), titanium oxide (Ti), strontium oxide (Sr), tin oxide (Sn), and zirconium oxide (Zr). The composition according to aspect 1.
(8) The composition according to embodiment 7, wherein M ² is titanium oxide (Ti).
(9) The compound of embodiment 1, wherein the compound of formula I is selected from the group consisting of potassium potassium oxalate oxide, titanium calcium oxalate, potassium potassium citrate oxide, potassium calcium oxalate and mixtures thereof. Composition.
(10) A composition according to embodiment 9, wherein the compound of formula I is potassium titanium oxalate oxide.

(11) A composition according to embodiment 9, wherein the compound of formula I is potassium titanium citrate oxide.
(12) The composition according to embodiment 1, further comprising a pH buffer.
(13) The pH buffer is citric acid-sodium citrate, phosphoric acid-sodium phosphate, monobasic sodium phosphate, dibasic sodium phosphate, acetic acid-sodium acetate, succinic acid-sodium succinate, aconitic acid- Embodiment 13. The composition of embodiment 12, which is an acid / acid salt combination selected from the group consisting of sodium aconitate and benzoic acid-sodium benzoate.
(14) The composition according to embodiment 1, further comprising a flavoring agent.
(15) The composition according to embodiment 1, further comprising a sweetening agent.
(16) The composition of embodiment 1, wherein the composition is in the form of a mouthwash, mouth rinse, dentifrice, paste, powder, gel, tablet, troche, microcapsule, strip or strip coating.
(17) The composition according to embodiment 1, wherein the composition is a coating or impregnating agent for a dental tool selected from the group consisting of a toothbrush, toothbrush hair, dental floss and dental pick.
(18) a) at least one compound of Formula ^{I M 1 -A-M 2 -B} -M 3 (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to dibasic acids C _5, are selected from the group consisting of tribasic and tetrabasic acids,
b) at least one additional desensitizer, and
c) at least one orally acceptable solvent,
An oral composition comprising:
(19) The additional desensitizer is selected from the group consisting of potassium citrate, potassium chloride, potassium nitrate, citric acid, citrate, strontium chloride, bioactive glass material, phosphopeptide and mixtures thereof. The composition according to embodiment 18.
(20) In the method of treating sensitive teeth,
19. The method comprising contacting the sensory sensitive tooth with the composition of embodiment 18 for at least about 10 seconds.

(21) A method for treating a sensory sensitive tooth comprising the step of applying the composition to the tooth at least twice in succession, wherein the composition comprises:
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to dibasic acids C _6, are selected from the group consisting of tribasic and tetrabasic acids, and,
b) at least one orally acceptable solvent,
Including
The method wherein the application interval does not exceed 12 hours.
22. The method of embodiment 21, wherein the composition is applied at least about 7 consecutive times.
23. The method of embodiment 21, further comprising contacting the teeth with the composition for at least about 10 seconds in each application period.
24. The method of embodiment 23, wherein in each application period the composition is in contact with the teeth for at least about 30 seconds.
25. The method of embodiment 21, wherein the compound of formula I is selected from the group consisting of potassium potassium oxalate oxide, potassium potassium citrate oxide, and mixtures thereof.
(26) A method for closing a dentin tubule of a tooth, comprising the step of applying the composition to the tooth continuously at least twice,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth with the composition for at least 20 seconds to close the tubules by at least about 5%.
27. The method of embodiment 26, wherein the tubule is closed at least 25%.
(28) A method of closing a dentin tubule of a tooth, comprising the step of applying the composition to the tooth continuously at least twice,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are each independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C ₂ to Selected from the group consisting of C ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth with the composition in the presence of calcium for at least 10 seconds;
The compound produces a precipitate on the teeth along with the calcium, thereby sonicating the teeth for 2 minutes using a sonicator CD-4800 with normal pulses, and then generating the precipitate A method wherein at least about 30% of the objects remain on the teeth.
(29) The compound produces a precipitate on the tooth along with the calcium such that at least about 25% of the generated precipitate remains on the tooth after sonication. 29. A method according to aspect 28.
(30) The compound produces a precipitate on the tooth along with the calcium such that at least about 50% of the generated precipitate remains on the tooth after sonication. 30. A method according to embodiment 29.

(31) A method for depositing a precipitate on a tooth or on a dentin tubule of a tooth, comprising the step of applying the composition to the tooth continuously at least twice,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein, M ¹ and M ³ are independently a monovalent or divalent metal, M ² is a polyvalent metal or metal oxide, and A and B are independently C _{2 to} C Selected from the group consisting of ₆ dibasic acids, tribasic acids and tetrabasic acids]
b) contacting the teeth with the composition in the presence of calcium for at least 10 seconds;
The method wherein M ² is present in the precipitate at a concentration of at least about 5% of the deposited precipitate.

Claims (15)

In an oral composition for the treatment of dental hypersensitivity ,
a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein M ¹ and M ³ are independently selected from potassium and calcium , M ² is titanium or titanium oxide , and A and B are independently selected from oxalic acid and citric acid. And,
b) an orally acceptable solvent containing at least water ,
Including
The oral composition, wherein the oral composition has a pH of at least 2.0. The pH is 2 . 5-7 . The composition of claim 1, which is zero. The composition of claim 1 , wherein M ¹ and M ³ are K. The composition of claim 1 , wherein M ² is Ti. M ² is titanium oxide emissions, the composition of claim 1.   2. The composition of claim 1, wherein the compound of formula I is selected from the group consisting of titanium potassium oxalate oxide, titanium calcium oxalate, potassium potassium citrate oxide, potassium calcium oxalate, and mixtures thereof. 7. The composition of claim 6 , wherein the compound of formula I is potassium titanium oxalate oxide. 7. The composition of claim 6 , wherein the compound of formula I is potassium titanium citrate oxide.   The composition of claim 1 further comprising a pH buffer. The pH buffer is citric acid-sodium citrate, phosphoric acid-sodium phosphate, monobasic sodium phosphate, dibasic sodium phosphate, acetic acid-sodium acetate, succinic acid-sodium succinate, aconitic acid-sodium aconitic acid and benzoic acid - a combination of acid / acid salt selected from the group consisting of sodium benzoate, the composition of claim 9.   The composition of claim 1 further comprising a flavoring.   The composition of claim 1 further comprising a sweetening agent.   The composition according to claim 1, wherein the composition is in the form of a mouthwash, mouthwash, dentifrice, paste, powder, gel, tablet, troche, microcapsule, strip or strip coating.   The composition of claim 1, wherein the composition is a coating or impregnating agent for a dental tool selected from the group consisting of a toothbrush, toothbrush bristles, dental floss and dental pick. a) at least one compound of formula I M ¹ -AM ² -BM ³ (I)
[Wherein M ¹ and M ³ are independently selected from potassium and calcium , M ² is titanium or titanium oxide , and A and B are independently selected from oxalic acid and citric acid. ]
b) at least one additional desensitizer selected from the group consisting of potassium citrate, potassium chloride, potassium nitrate, citric acid, citrate, strontium chloride, bioactive glass materials, phosphopeptides and mixtures thereof , and ,
c) an oralally acceptable solvent containing at least water ,
An oral composition for treating hypersensitive teeth .

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