WO2022034846A1

WO2022034846A1 - Oral cavity composition

Info

Publication number: WO2022034846A1
Application number: PCT/JP2021/029059
Authority: WO
Inventors: 夏芽萩森; 侑季塩崎
Original assignee: ライオン株式会社
Priority date: 2020-08-11
Filing date: 2021-08-05
Publication date: 2022-02-17
Also published as: JPWO2022034846A1

Abstract

Provided is an oral cavity composition that is configured such that unpleasant taste and irritation resulting from component (A), (B) or (C) are masked and suppressed, that provides a natural, deep, and unique refreshing feeling, and that has an excellent feeling of use.　The oral cavity composition comprises: at least one component selected from among (A)-(C), (A) at least one selected from potassium salt (A-1) and a water-soluble multivalent metal salt (A-2) at 0.01-20 mass%, (B) condensed phosphate at 0.1-2 mass%, and (C) an anionic surfactant at 0.1-5 mass%; (D) two or three selected from among caryophyllene, germacrene, and viridiflorol; and (E) one or more selected from menthol and carvone. The content of component (D) is 0.01-50 parts by mass with respect to 100 parts by mass of component (E).

Description

Oral composition

The present invention relates to an oral composition that masks unpleasant tastes and irritation caused by metal salts and the like, has a natural and deep unique refreshing sensation (natural mint sensation), and is excellent in usability.

In recent years, multi-functional oral care preparations have been preferred, and compositions in which a plurality of active ingredients are combined have been developed. There are many substances that impair the usability of the oral composition.
Typical ingredients include potassium nitrate, which is an active ingredient with an inhibitory effect on hypersensitivity, and has a nerve blunting effect, aluminum lactate, which is a polyvalent metal salt having an ivory tubule blockage effect, and copper salt, zinc salt, and tin. There are other polyvalent metal salts such as salts, condensed phosphates known to have an effect of suppressing stain adhesion on teeth, etc., but these have a metallic taste and irritation. In addition, some anionic surfactants, which are generally blended in oral compositions and enhance foaming, have a bitter taste and irritation. Therefore, if any of the above ingredients is blended, in addition to the unpleasant taste derived from these components, the irritation to the oral cavity may be remarkably increased and the usability may be deteriorated. Tends to cause further deterioration of.
Regarding masking of unpleasant tastes, etc., in Patent Document 1 (Japanese Patent Laid-Open No. 2006-96696), a relatively large amount of polyhydric alcohol is blended in a combination system of potassium nitrate and a water-soluble polyphosphate in a specific ratio. The taste has been improved. In Patent Document 2 (Japanese Unexamined Patent Publication No. 2017-210454), by combining a potassium salt and / or an aluminum salt with a specific fragrance component such as sodium chloride and allylphenoxyacetate, metallic taste and irritation are suppressed, and the metal taste and irritation are suppressed. It has succeeded in giving a refreshing feeling after use. In Patent Document 3 (Japanese Unexamined Patent Publication No. 2017-141178), potassium nitrate and / or aluminum lactate is blended with α-olefin sulfonate and sucralose in combination to provide excellent hypersensitivity suppressing effect and foaming performance. Moreover, it has succeeded in improving the overall taste. Further, Patent Document 4 (Japanese Unexamined Patent Publication No. 2003-137755) proposes a technique for suppressing metallic taste by using a menthol derivative.

On the other hand, oral care preparations are preferably given a refreshing sensation, and the oral composition often contains a mint flavor containing menthol or carboxylic as a fragrance component, and as a mint flavor, For example, in addition to artificial mint flavors, natural essential oils such as menthol-based peppermint oil, peppermint oil, and carboxylic-based sparemint oil may be used, and these mint-based flavors are effective in improving flavor. Is.

Japanese Unexamined Patent Publication No. 2006-96696 Japanese Unexamined Patent Publication No. 2017-210454 Japanese Unexamined Patent Publication No. 2017-141178 Japanese Patent Application Laid-Open No. 2003-137755

However, in oral compositions, there has been a technique for improving the usability by masking unpleasant tastes and irritation derived from metal salts, condensed phosphates or anionic surfactants with specific components. In the oral composition containing a mint-based flavor together with these components, there is room for improvement in the mint-based flavor, and improvement in usability has been an issue.

The present invention has been made in view of the above circumstances, and is used for the oral cavity, which has a unique refreshing sensation that is natural, deep and has a unique refreshing sensation that is masked and suppressed from unpleasant tastes and irritation caused by metal salts and the like. It is an object of the present invention to provide a composition.

As a result of diligent studies to achieve the above object, the present inventors have added cariophyllene as a mint flavor to an oral composition containing a specific amount of a specific component such as a specific metal salt having an unpleasant taste or irritation. , Germaclen and bilidiflorol, and one or more selected from menthol and carvone in combination in a specific amount ratio, which is unpleasant derived from the specific component such as the specific metal salt. The taste and irritation are masked, the bitterness and irritation associated with them are suppressed and improved, and the refreshing sensation due to the mint flavor is not impaired, and the refreshing sensation is noticeably expressed. It was found that it is possible to give a feeling) and give an excellent feeling of use. That is, in the present invention, at least one selected from the following components (A) to (C) (A) potassium salt (A-1) and water-soluble polyvalent metal salt (A-2) 0.01 to 20 mass%,
(B) Condensed phosphate 0.1 to 2% by mass, and (C) Anionic surfactant 0.1 to 5% by mass.
In an oral composition containing one or more components selected from, (D) two or three selected from cariophyllene, germacrene and viridiflorol, and (E) one or more selected from menthol and carvone. , (E) The content of the component (D) is 0.01 to 50 parts by mass with respect to 100 parts by mass, so that the unpleasantness derived from the components (A), (B) and (C) is caused. It has been found that the taste and irritation are masked and suppressed, the natural and deep unique refreshing sensation is obtained, and the feeling of use is excellent, and the present invention has been made.

In the present invention, two or three specific substances are used in combination as the component (D), and the combination system and the component (E) are combined and blended in a specific amount ratio to form (A), (B) and. Even in an oral composition containing the three components of (C), these unpleasant tastes and irritation are suppressed, and a unique, natural and deep refreshing sensation (sharp scent, taste and thickness). It is possible to give a unique and natural refreshing sensation that is different from the refreshing sensation without a scent. Hereinafter, it may be abbreviated as a natural refreshing sensation), and it is possible to give a remarkably excellent feeling of use.
As shown in the comparative example described later, even if a mint flavor is blended, if the substance of the component (D) is one kind, the bitterness / irritation during use and the natural refreshing feeling are inferior (comparison). Examples 3 to 5), and even if two or three substances are blended as the component (D), if the amount ratio of the component (D) and the component (E) is inappropriate, a natural refreshing sensation is obtained. (Comparative Examples 1 and 2), and Comparative Example 2 in which the amount ratio was too small was also inferior in bitterness and no irritation during use. On the other hand, the oral composition of the present invention shown in the examples is excellent in both no bitterness and irritation during use and a natural refreshing sensation, unpleasant taste and irritation are suppressed, and is natural and deep. It had a certain refreshing feeling.

Therefore, the present invention provides the following oral compositions.
[1]
One or more selected from the following components (A) to (C) (A) potassium salt (A-1) and water-soluble polyvalent metal salt (A-2) 0.01 to 20% by mass,
(B) Condensed phosphate 0.1 to 2% by mass, and (C) Anionic surfactant 0.1 to 5% by mass.
With one or more ingredients selected from
(D) Two or three species selected from caryophyllene, germacrene and viridiflorol, and
(E) An oral composition containing one or more selected from menthol and carvone, and the content of the component (D) is 0.01 to 50 parts by mass with respect to 100 parts by mass of the component (E).
[2]
The oral composition according to [1], wherein the potassium salt (A-1) is selected from potassium nitrate, potassium citrate, potassium chloride and potassium sulfate.
[3]
The oral composition according to [1] or [2], wherein the water-soluble polyvalent metal salt (A-2) is selected from a copper salt, a zinc salt, an aluminum salt and a tin salt.
[4]
The water-soluble polyvalent metal salt (A-2) is selected from the chlorides, citrates, lactates, gluconates, malonates, malates and sulfates of polyvalent metals [1]. The oral composition according to any one of [3].
[5]
(B) The oral composition according to any one of [1] to [4], wherein the condensed phosphate is one or more selected from tripolyphosphate, pyrophosphate and hexametaphosphate.
[6]
(C) The anionic surfactant is an acyl taurine salt, an acyl amino acid salt, an α-olefin sulfonate, an alkyl sulfo acetate, an alkenyl sulfo acetate, a polyoxyethylene alkyl ether phosphate and a polyoxyethylene alkenyl ether phosphorus. The oral composition according to any one of [1] to [5], which is one or more selected from the acid salts.
[7]
(D) The oral composition according to any one of [1] to [6], which contains 0.0002 to 0.3% by mass of the component.
[8]
The oral composition according to any one of [1] to [7], which is a dentifrice, a mouthwash, a mouth spray, a coating agent or a patch.

According to the present invention, the unpleasant taste and irritation derived from the components (A), (B) and (C) are masked and improved, and a natural, deep and unique refreshing sensation is obtained. It is possible to provide an excellent oral composition. In the oral composition of the present invention, the medicinal effects of the components (A), (B) and (C) can be given under an excellent feeling of use accompanied by a unique refreshing sensation of the mint system, and hypersensitivity. It is effective for prevention or suppression of oral diseases such as periodontal disease.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention is one or more selected from the following components (A) to (C) (A) potassium salt (A-1) and water-soluble polyvalent metal salt (A-2).
One or more components selected from (B) condensed phosphate and (C) anionic surfactant, two or three selected from (D) caryophyllene, germacrene and bilidiflorol, (E) menthol and Contains one or more selected from carboxylic acids.

The component (A) is one or more selected from the potassium salt (A-1) and the water-soluble polyvalent metal salt (A-2), and the potassium salt (A-1) is particularly preferable.
The blending amount of the component (A) is adjusted according to the substance type used, but can be 0.01 to 20% (mass%, the same applies hereinafter) with respect to the entire composition.

Potassium salt (A-1) has a nerve blunting effect and is effective in preventing hyperesthesia.
Examples of the potassium salt include potassium nitrate, potassium citrate, potassium chloride, potassium sulfate and the like, and these can be used alone or in combination of two or more. Of these, potassium nitrate is preferable.
As the potassium nitrate, for example, a commercially available product manufactured by Otsuka Chemical Co., Ltd. can be used.

The blending amount of the potassium salt is preferably 0.1 to 15%, more preferably 0.5 to 10%, still more preferably 1 to 8% of the whole composition. When the blending amount exceeds 15%, the unpleasant taste associated with these own metallic tastes is strongly felt as bitterness and irritation, masking cannot be performed, and the usability deteriorates. The larger the blending amount, the higher the hypersensitivity suppressing effect, but even if the blending exceeds 15%, the increase in the hypersensitivity suppressing effect corresponding to the increase in the blending amount cannot be expected, but rather a strong metallic taste is generated.

The water-soluble polyvalent metal salt (A-2) is preferably an aluminum salt, a copper salt, a zinc salt, or a tin salt, and the salt is a polyvalent metal citrate, lactate, gluconate, or malonate. , Apple salt, sulfate, chloride and the like. These can be used alone or in combination of two or more. The water-soluble polyvalent metal salt has an action depending on the substance type, for example, an action of imparting a tightening feeling to the gingiva, an action of suppressing bad breath and the like.
The total component (A-2) is 0.01 to 5% with respect to the entire composition. In particular, it is preferable to blend in the range of 0.03 to 3%.

Examples of the aluminum salt include aluminum lactate, aluminum gluconate, aluminum malonate, aluminum malate and the like.
The blending amount of the aluminum salt is preferably 0.01 to 5%, more preferably 0.03 to 3% of the entire composition. In the above range, the ivory capillary tube blocking action and the like can be sufficiently obtained, and the suppression of metallic taste is particularly good.
Further, potassium aluminum sulfate can also be used, and potassium aluminum sulfate has an effect of imparting a tightening feeling to the gingiva, and from the viewpoint of suppressing the tightening feeling of the gingiva and the metallic taste, the blending amount thereof is the entire composition. 0.01 to 5% is preferable, and 0.03 to 3% is more preferable.
Examples of the copper salt include water-soluble copper salts such as copper gluconate, copper citrate, and copper sulfate, and examples of the zinc salt include zinc citrate, zinc lactate, zinc gluconate, zinc chloride, and the like, and tin salts. Examples thereof include tin citrate, tin lactate, tin gluconate, tin chloride and the like.
The blending amount of the copper salt, zinc salt and tin salt is preferably 0.01 to 3%, more preferably 0.03 to 2% of the total composition. In the above range, the action of suppressing bad breath or the feeling of tightening of the gingiva can be sufficiently obtained, and the suppression of metallic taste is particularly good.

(B) Condensed phosphate has a stain adhesion suppressing effect.
Examples of the condensed phosphate include linear polyphosphates such as pyrophosphate, tripolyphosphate and tetrapolyphosphate, and cyclic polyphosphates such as trimetaphosphate, tetramethaphosphate and hexametaphosphate, and the salts include sodium salt and potassium. Salt is mentioned. These can be used alone or in combination of two or more. Among them, pyrrophosphate, tripolyphosphate and hexametaphosphate are preferable, and sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, potassium tripolyphosphate, sodium hexametaphosphate and potassium hexametaphosphate are particularly preferable.
As the condensed phosphate, commercially available products such as sodium pyrophosphate and sodium tripolyphosphate manufactured by Taihei Kagaku Sangyo Co., Ltd. can be used.

The blending amount of (B) condensed phosphate is preferably 0.1 to 2%, more preferably 0.2 to 2%, and even more preferably 0.5 to 1.2% of the entire composition. The larger the blending amount, the more the effect of suppressing stain adhesion is sufficiently exhibited, but when the blending amount exceeds 2%, the irritation of itself becomes too strong and masking cannot be performed, and the usability is inferior.

(C) The anionic surfactant is a surfactant effective for ensuring foaming.
Examples of the anionic surfactant include acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, alkyl sulfoacetates, alkenyl sulfo acetates, polyoxyethylene alkyl ether phosphates, polyoxyethylene alkenyl ether phosphates and the like. These can be used alone or in combination of two or more. The alkyl group, alkenyl group, and acyl group of the above substance preferably have 10 to 18 carbon atoms, respectively. Examples of the salt include alkali metal salts and ammonium salts, and sodium salts and potassium salts are preferable.
Specific examples thereof include, but are not limited to, lauroyl glutamate, N-lauroyl sarcosine salt, lauroyl methyl taurine salt, tetradecene sulfonate, lauryl sulfoacetate, and polyoxyethylene oleyl ether phosphate.

The blending amount of the (C) anionic surfactant is preferably 0.1 to 5%, more preferably 0.1 to 2%, and particularly preferably 0.1 to 0.5% of the entire composition. When the blending amount is 0.1% or more, sufficient foaming can be obtained, but when it exceeds 5%, the bitterness and irritation of itself become too strong and masking cannot be performed, and the usability is inferior.

The above-mentioned components (A), (B), and (C) can be blended alone or in combination of two or more components, and can also be blended in combination of three components. In the present invention, even if the three components (A), (B) and (C) are blended at the same time, the bitterness and irritation are masked and improved, and an excellent usability can be given.
The component (A) may overlap with the component (B) or (C). In that case, a substance other than the component (B) or (C) may be used as the component (A). can.

The component (D) is 2 or 3 selected from caryophyllene, germacrene and viridiflorol, and it is preferable to use 3 in combination.
The component (D) masks and suppresses the bitterness and irritation derived from the components (A), (B), and (C), and imparts a natural, deep and unique refreshing sensation (natural mint sensation). It works.
Examples of caryophyllene include β-caryophyllene.
As the component (D), caryophyllene, germacrene, and viridiflorol can be blended as a single fragrance material, but can also be blended as an extract of an essential oil or the like containing each substance.
As the component (D), one obtained by chemical synthesis may be used, one obtained by extracting from a natural product (extract from a natural product) may be used, or one obtained from a natural product. The obtained product and the product obtained by chemical synthesis may be used in combination, or a commercially available product may be used.

The component (D) is preferably blended in the amount ratio shown below, and when it is within the following range, bitterness and irritation can be further suppressed and a more natural refreshing sensation can be imparted.
When caryophyllene and germacrene are blended, the caryophyllene: germacrene (mass ratio) is preferably 1: 0.2 to 1: 2.5, more preferably 1: 1 to 1: 2.5.
When caryophyllene and viridiflorol are blended, the caryophyllene: viridiflorol (mass ratio) is preferably 1: 0.3 to 1: 5, and more preferably 1: 1 to 1: 5.
When caryophyllene, germacrene and viridiflorol are blended, the caryophyllene: germacrene: viridiflorol (mass ratio) is preferably 1: (0.2 to 2.5) :( 0.3 to 5), more preferably 1: (1). ~ 2.5): (1 ~ 5).

Specifically, as such a component (D), caryophyllene is caryophyllene-BE (manufactured by Inoue Perfum Manufacturing Co., Ltd.), germacrene is Germacrene D (manufactured by Toronto Research), and viridiflorol is viridiflorol (manufactured by Toronto Research). Commercial products such as can be used.
Specific examples of the extract such as essential oils include peppermint oil containing cariophyllene, germaneclen and bilidiflorol, Japanese mint oil containing cariophyllene and germanacren, spearmint oil containing cariophyllene and bilidiflorol, and artificial mint containing cariophyllene, germaneclen and bilidiflorol. Oils and the like can be used, and these can be extracted from plants of the genus Mentha of the Labiatae family by a known method, and may be commercially available products.

Further, as the component (D), the essential oil produced by the following production method (essential oil containing the component (D)) can be preferably used as the extract from the natural product (see Japanese Patent Application No. 2020-87507).
The raw material is a Labiatae Menta plant, and as the Labiatae Menta plant, peppermint, mint, and spearmint can be used, and the essential oil obtained by known distillation can be preferably used.
The above Labiatae plant-derived oil (raw essential oil) is 40 to 0.05 bar, preferably 0.002 to 0.04 bar, more preferably 0.004 to 0.03 bar, at a pressure of 0.00001 to 0.05 bar. Precision distillation is performed at 250 ° C., preferably 60 to 180 ° C., more preferably 80 to 140 ° C., and 75 to 97%, preferably 92 to 96% of the total amount of the Labiatae plant-derived oil is used as the volatile part A. It is recovered to obtain a distillation residue consisting of the non-volatile part A of 3 to 25%, preferably 4 to 8% of the total amount of the oil derived from the Labiatae plant. The conditions for precision distillation are preferably such that the pressure is 0.002 to 0.04 bar and 60 to 180 ° C, and more preferably the pressure is 0.004 to 0.03 bar and 80 to 140 ° C. By precision distillation under such conditions, the component (D) can be concentrated in the distillation residue.
Next, the distillation residue (nonvolatile part A) is thin-film distilled, and a volatile fraction (first volatile fraction) consisting of a volatile part B of 5 to 50%, preferably 10 to 30% of the total amount of the distillation residue. To get. The essential oil thus obtained can be used as the essential oil containing the component (D). The distillation conditions for obtaining the volatile fraction (first volatile fraction) are preferably 90 to 180 ° C. and a pressure of 0.00001 to 0.01 bar, preferably 140 to 160 ° C. More preferably, the pressure is 0.002 to 0.008 bar.
The second volatile fraction, which is obtained by further thin-film distillation of the volatile portion B and consists of the volatile portion C of 50 to 95%, preferably 60 to 95%, more preferably 60 to 90% of the total amount of the volatile portion B. , A more preferable (D) component-containing essential oil. The distillation conditions for obtaining the second volatile fraction are preferably 90 to 180 ° C. and a pressure of 0.00001 to 0.01 bar, and 140 to 160 ° C. and a pressure of 0.002 to 0.008. More preferably done in a bar. The second volatile fraction is particularly preferable in terms of exhibiting the effects of the present invention, because components such as tar that contribute more to the unpleasant taste are removed from the second volatile fraction as compared with the first volatile fraction.
The essential oil containing the component (D) thus obtained contains two or more substances selected from β-caryophyllene, germacrene D and viridiflorol in a total of 15 to 50%, preferably 20 to 40%, more preferably. It contains 30 to 40% and is suitable as the component (D).

The blending amount of the component (D) is adjusted so that the amount ratio with the component (E) is in an appropriate range, but it is preferably 0.0002 to 0.3% of the whole composition, and more preferably 0.0004. It is ~ 0.3%. When the blending amount is 0.0002% or more, a natural and deep refreshing sensation is sufficiently obtained, and when it is 0.3% or less, the taste derived from the component (D) has little influence on the flavor.

The component (E) is one or two selected from menthol and carvone. These are refreshing sensation-imparting agents and are also the main components of mint flavors.
The component (E) can also be blended as an essential oil containing menthol (L-menthol) and / or carvone. Specifically, peppermint oil, spearmint oil, Japanese mentha oil, and artificial mint oil obtained by a known method can be used.
Further, a commercially available product can also be used. For example, L-menthol (manufactured by Takasago International Corporation), carvone (manufactured by Shiono Koryo Kaisha) and the like can be used.

The blending amount of the component (E) is preferably 0.05 to 2%, more preferably 0.1 to 1.5% of the entire composition. When the blending amount is 0.05% or more, a natural and deep refreshing sensation is sufficiently obtained, and when it is 2% or less, the stimulus derived from the component (E) does not deteriorate the usability.

In the present invention, when essential oils such as peppermint oil, spearmint oil, Japanese mint oil, artificial mint oil, and essential oils from the above natural products are blended as the components (D) and (E), each of the essential oils ( There is a possibility that the components D) and (E) may be contained, but in that case, the components in each essential oil are added up and totaled, and treated as the total amount of the components (D) and the total amount of the components (E).

The ratio (amount ratio) of the component (D) to the component (E) is such that the amount of the component (D) is 0.01 to 50 parts by mass with respect to 100 parts by mass of the component (E). It is preferably 0.05 to 10 parts by mass, more preferably 0.1 to 2.5 parts by mass, and most preferably 0.4 to 2.5 parts by mass. Within the above range of the amount ratio, the bitterness and irritation derived from the components (A), (B) and (C) are masked and improved, and a natural and deep refreshing sensation is obtained. It will be a feeling of use. If the component (D) is less than 0.01 parts by mass with respect to 100 parts by mass of the component (E), the bitterness and no irritation are inferior, and if it exceeds 50 parts by mass, the natural refreshing feeling is inferior.

The oral composition of the present invention can be used as a dentifrice, a mouthwash, a mouth spray, a coating agent, a patch, and the like. Of these, dentifrices and mouthwashes are preferable, and dentifrices are particularly preferable, in terms of exhibiting the effects of the present invention. The form can be liquid, liquid, paste, etc., and the dentifrice can be prepared as a dentifrice, a liquid dentifrice, a liquid dentifrice, a dentifrice, etc., especially as a dentifrice. preferable. In this case, in addition to the above components, other optional components depending on the intended use, dosage form, etc. can be appropriately blended as long as the effects of the present invention are not impaired. Specifically, in the dentifrice, a surfactant, an abrasive, a thickening agent, a binder, and if necessary, a sweetening agent, a preservative, a pigment, a fragrance, various active ingredients and the like can be blended.

As the surfactant, in addition to the above components, a nonionic surfactant and an amphoteric surfactant can be blended.
Examples of the nonionic surfactant include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, mono-lauric acid or diethanolamides, and sorbitan fatty acid esters. Among these, in particular, polyoxyethylene hydrogenated castor oil (particularly those having an addition molar number of 10 to 30 of ethylene oxide) and polyoxyethylene alkyl ether (especially those having an addition mole number of ethylene oxide of 3 to 5 and an alkyl moiety carbon). (Chain lengths of 16 to 18) are preferable from the viewpoint of solubilization.
Amphoteric tensides include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1-hydroxyethylimidazoline betaine sodium. Can be mentioned.
The blending amount of these surfactants is preferably 0.1 to 5%, particularly 0.1 to 4% of the entire composition.

The abrasives are silica-based abrasives such as crystalline silica, amorphous silica, silica gel, and aluminosilicate, zeolite, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, and water. Examples thereof include aluminum oxide, alumina, magnesium carbonate, magnesium tertiary phosphate, zirconium silicate, calcium tertiary phosphate, hydroxyapatite, calcium tetraphosphate, and synthetic resin-based abrasives. The blending amount of the abrasive is usually 5 to 70%, particularly 10 to 50% of the whole composition.

Examples of the viscous agent include sugar alcohols such as sorbitol, xylit and erythritol, and polyhydric alcohols such as propylene glycol, butylene glycol, glycerin and polyethylene glycol. The blending amount of the thickener is usually 0 to 70% of the whole composition, particularly 3 to 50%.
As the binder, an organic binder or an inorganic binder can be used. Examples thereof include organic binders such as xanthan gum and sodium carboxymethyl cellulose, and inorganic binders such as thickening silica and thickening aluminum silica. The blending amount of the binder is usually 0.1 to 10%, particularly 0.1 to 8% of the whole composition.

Examples of the sweetening agent include saccharin sodium and the like.
Examples of the preservative include benzoates such as sodium benzoate and paraoxybenzoic acid esters such as methylparaben, ethylparaben and butylparaben.
Examples of the dye include brilliant blue, which is an edible dye, tartrazine, and titanium oxide, which is a pigment.

Optional fragrances include, for example, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, cardamon oil, coriander oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil. , Yuzu oil, lavender oil, rosemary oil, laurel oil, perilla oil, camomill oil, caraway oil, majorum oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, patchouli Natural fragrances such as oil, paracress oil, iris concrete, rose absolute, orange flower absolute, vanilla absolute, lavender absolute, patchuriabsolute, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid) Liquid extraction, essence, powdered fragrance, etc.), limonen, pinen, butanol, isoamyl alcohol, hexenol, linalol, anator, timol, eugenol, menton, pregon, fencon, cineole, hexanal, octanal, anisaldehyde, synamic Alaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, linaryl acetate, menthyl acetate, calvier acetate, phenoxyethyl isobutyrate, methyl epijasmonate, methyl salicylate, ethyl salicylate, methyl anthranilate, ethyl methyl Single item such as phenylglycidate, ethyllactate, vanillin, maltol, gamma or deltalactone having 4 to 12 carbon atoms, ambretlide, dimethylsulfide, trimethylpyrazine, ethylthioacetate, vanillylbutyl ether, piperin, capsaicin, zingerol, spirantol, etc. Fragrances, Strawberry Flavor, Apple Flavor, Banana Flavor, Pineapple Flavor, Grape Flavor, Mango Flavor, Ume Flavor, Orange Flavor, Lemon Flavor, Yuz Flavor, Grapefruit Flavor, Butter Flavor, Milk Flavor, White Floral Flavor, Gardenia Flavor, Known fragrance materials used in oral compositions, such as compounded fragrances such as rose flavor and tea flavor, can be used in combination. The blending amount of these fragrance materials is not particularly limited, but it is preferable to use 0.000001 to 1% in the composition. Further, it is preferable to use 0.1 to 2.0% of the perfume for perfume using the above perfume material in the composition.
When any fragrance contains the components (D) and / or (E), it can be used within the range of the blending amount of the components (D) and / or (E) described above.

The active ingredient (medicinal ingredient) is a bactericidal or antibacterial agent such as chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, a tooth stone preventive agent such as ethanehydroxydiphosphonate, tranexamic acid, glycyrrhizin. Acids or salts thereof, enzyme agents such as dextranase, mutanase, lysoteam chloride, vitamins such as ascorbic acid and tocopherol acetate, astringent agents such as sodium chloride, fluorides such as sodium fluoride and sodium monofluorophosphate, etc. , Can be used within a pharmaceutically acceptable range.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Oral compositions (dentifrices) having the compositions shown in Tables 1 to 6 were prepared by a conventional method, and the usability was evaluated by the following method. The results are also shown in the table.

Evaluation method of usability When 10 subject monitors put the oral composition (dentifrice) on a toothbrush and brushed their teeth by the usual method to clean the oral cavity, the usability (no bitterness or irritation during use). , Natural refreshing feeling) was evaluated according to the following evaluation criteria. The evaluation points of 10 people were averaged and judged according to the following criteria.
Here, the natural refreshing sensation is a unique refreshing sensation that is natural and deep, which is different from the refreshing sensation that has a sharp scent and no taste or thickness.
(I) No bitterness / irritation during use Evaluation criteria 4 points: No bitterness / irritation is felt in the oral cavity.
3 points: I feel a little bitterness and irritation in the oral cavity.
2 points: I feel bitterness and irritation in the oral cavity.
1 point: Very bitter and irritating in the oral cavity.
Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score 2. Less than 0 points (ii) Natural refreshing feeling Evaluation criteria 4 points: I feel a very natural and deep refreshing feeling.
3 points: Feel a natural and deep refreshing feeling.
2 points: I feel a little natural and deep refreshing feeling.
1 point: I do not feel a natural and deep refreshing feeling.
Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score 2. Less than 0 points

Details of the raw materials used are shown below.
(D) Ingredients Caryophyllene (D1): Caryophyllene-BE (manufactured by Inoue Perfum)
Germacrene (D2): Germacrene D (manufactured by Toronto Research)
Viridiflorol (D3): Viridiflorol (manufactured by Toronto Research)
The component (E) may be blended as a fragrance 1 (mint flavor), but the fragrance 1 may contain the component (D). The following peppermint oil, spearmint oil, Japanese mentha oil, and artificial mint oil were used in the fragrance 1.
Peppermint oil (made by ADM):
(D) component is 3.4% (caryophyllene (D1) 2%, germacrene (
D2) Contains 1.2%, Viridiflorol (D3) 0.2%) (E) Contains 42% menthol Japanese menthol oil (manufactured by Toyo Mentha Industries):
(D) Contains 1.03% (caryophyllene (D1) 1%, germacrene (D2) 0.03%) (E) contains 42% menthol Spearmint oil (manufactured by ADM):
(D) Contains 0.8% (caryophyllene (D1) 0.5%, germaneclin (D2) 0.3%) (E) contains 60% carvone Artificial mint oil (manufactured by Takasago International Corporation):
(D) component is 3.2% (caryophyllene (D1) 2%, germacrene (
D2) Contains 1%, Viridiflorol (D3) 0.2%) (E) Contains 42% menthol Fragrance 2 has the following composition (fragrance component other than mint).
Composition of fragrance 2:
Anethole 10
Clove oil 0.4
Coriander oil 2
Thyme oil 0.4
Black tea flavor 10
Lavender oil 1
Jasmine oil 1
Fruit flavor 1
Ethanol 74.2
100% in total

*; The total amount of the (D) component ((D1) + (D2) + (D3)), which is the sum of the amounts of the (D) component contained in the fragrance 1.
**; Caryophyllene (D1), germacrene (D2), and bilidiflorol (D3) contained in perfume 1 were also added up and calculated (D1) :( D2) :( D3) (mass ratio).
***; The component (E) was blended as perfume 1.

Free Answer Example 1: There is no bitterness or irritation, and a natural, deep and unique refreshing feeling is felt.
Comparative Example 1: There is no bitterness or irritation, but the odor of the single ingredient is strong, and it lacks the naturalness of a refreshing feeling.
Comparative Example 2: Bitterness and irritation are slightly suppressed. It lacks the naturalness of a slightly refreshing feeling.
Comparative Example 3: There is bitterness and irritation, and a sharp, tasteless and refreshing feeling is felt.
Comparative Example 4: There is bitterness and irritation, and a sharp, tasteless and refreshing feeling is felt.
Comparative Example 5: There is bitterness and irritation, and a sharp, tasteless and refreshing feeling is felt.

[Example 32]
(A) Potassium nitrate 5
(B) Sodium tripolyphosphate 1
(C) Sodium lauroylmethyl taurine 0.4
(D) Peppermint essential oil C ^(*) 0.006
(E) Menthol 0.5
Xanthan gum 1.6
Coconut oil fatty acid amide propyl betaine 0.6
Mica Titanium 0.7
Sorbitol 28
Propylene glycol 4
Abrasive silica 10
Viscous silica 5
Sodium fluoride 0.32
Saccharin sodium 0.17
Methyl paraoxybenzoate 0.18
Fragrance 2 0.5
Purified water residue
100% in total
(*); Peppermint essential oil C
500 kg of peppermint oil (manufactured by ADM) is used as crude oil and distilled under reduced pressure (temperature 80 to 140 ° C., pressure 0.01 to 0.02 bar) to obtain a volatile part A and a non-volatile part A of 28.9 kg. rice field. Next, the obtained non-volatile part A was subjected to thin film distillation (heat medium temperature 150 ° C., pressure 0.0040 bar) to obtain a volatile part B and a 23.1 kg non-volatile part B. The obtained volatile part B was further subjected to thin film distillation (heat medium temperature 150 ° C., pressure 0.0040 bar) to obtain 4.6 kg of volatile part C. The amount of (D) component (contents of (D1), (D2), (D3) component) in the obtained volatile part C (peppermint essential oil C) was β-caryophyllene 7%, germacrene 13%, viridiflorol 17%. Met.
Amount of (D) component in composition (D1) 0.00042%, (D2) 0.00078%, (D3) 0.0010%
(D) Total amount of components ((D1) + (D2) + (D3)); 0.0022
(D1) :( D2) :( D3) (mass ratio); 1: 1.85: 2.38
(E) Total amount of component (D) with respect to 100 parts by mass (parts by mass); 0.44
When the dentifrice of Example 32 was prepared and evaluated in the same manner as in the above-mentioned Example, it was evaluated.
No bitterness or irritation during use ◎
Natural refreshing feeling ◎
Met.

[Example 33] Toothpaste (A) Copper gluconate 0.1
(B) Sodium tripolyphosphate 1
(C) Sodium lauroylmethyl taurine 1
(D) Caryophyllene (D1) 0.000426
(D) Germacrene (D2) 0.000786
(D) Viridiflorol (D3) 0.001000
(E) Menthol 0.53
Abrasive silica 12
Viscous silica 3
Glycerin (85%) 40
Propylene glycol 3
Sodium citrate 0.2
Sodium monofluorophosphate 0.7
Sodium Carboxymethyl Cellulose 1
Xanthan gum 0.3
Saccharin sodium 0.1
Titanium oxide 0.5
Fragrance 0.5
Purified water residue
100% in total
(D) Total amount of components ((D1) + (D2) + (D3)); 0.002212
(D1) :( D2): (D3) (mass ratio); 1: 1.85: 2.35
(E) Total amount of component (D) with respect to 100 parts by mass (parts by mass); 0.41736

[Example 34] Toothpaste (A) Potassium nitrate 5
(A) Stannous fluoride 0.4
(B) Sodium hexametaphosphate 1.0
(C) Sodium lauryl sulfate 1.2
(C) Sodium tetradecene sulfonate 0.3
(D) Peppermint essential oil C ^(*) 0.006
(E) Menthol 0.5
Abrasive silica 15
Viscous silica 3
Sorbitol 35
Propylene glycol 3
Sodium citrate 0.2
Sodium monofluorophosphate 0.38
Sodium Carboxymethyl Cellulose 1
Xanthan gum 0.3
Saccharin sodium 0.1
Titanium oxide 0.5
Sodium hydroxide 0.2
Fragrance 0.5
Purified water residue
100% in total
Amount of (D) component in composition (D1) 0.00042%, (D2) 0.00078%, (D3) 0.0010%
(D) Total amount of components ((D1) + (D2) + (D3)); 0.0022
(D1) :( D2) :( D3) (mass ratio); 1: 1.85: 2.38
(E) Total amount of component (D) with respect to 100 parts by mass (parts by mass); 0.44

[Example 35] Toothpaste (A) Potassium nitrate 5
(A) Aluminum lactate 2
(B) Potassium pyrophosphate 1.2
(C) Sodium lauryl sulfate 1.2
(C) Sodium lauroyl glutamate 0.3
(D) Peppermint essential oil C ^(*) 0.006
(E) Menthol 0.5
Abrasive silica 16
Viscous silica 3
Sorbitol 20
Glycerin (80%) 10
Propylene glycol 3
Sodium monofluorophosphate 1.1
Sodium Carboxymethyl Cellulose 1
Xanthan gum 0.3
Saccharin sodium 0.1
Titanium oxide 0.5
Sodium hydroxide 0.2
Fragrance 0.5
Purified water residue
100% in total
Amount of (D) component in composition (D1) 0.00042%, (D2) 0.00078%, (D3) 0.0010%
(D) Total amount of components ((D1) + (D2) + (D3)); 0.0022
(D1) :( D2) :( D3) (mass ratio); 1: 1.85: 2.38
(E) Total amount of component (D) with respect to 100 parts by mass (parts by mass); 0.44

Claims

One or more selected from the following components (A) to (C) (A) potassium salt (A-1) and water-soluble polyvalent metal salt (A-2) 0.01 to 20% by mass,
(B) Condensed phosphate 0.1 to 2% by mass, and (C) Anionic surfactant 0.1 to 5% by mass.
With one or more ingredients selected from
(D) Two or three species selected from caryophyllene, germacrene and viridiflorol, and
(E) An oral composition containing one or more selected from menthol and carvone, and the content of the component (D) is 0.01 to 50 parts by mass with respect to 100 parts by mass of the component (E).
The oral composition according to claim 1, wherein the potassium salt (A-1) is selected from potassium nitrate, potassium citrate, potassium chloride and potassium sulfate.
The oral composition according to claim 1 or 2, wherein the water-soluble polyvalent metal salt (A-2) is selected from a copper salt, a zinc salt, an aluminum salt and a tin salt.
Claim 1 in which the water-soluble polyvalent metal salt (A-2) is selected from the chloride, citrate, lactate, gluconate, malonate, malate and sulfate of the polyvalent metal. The oral composition according to any one of 3 to 3.
(B) The oral composition according to any one of claims 1 to 4, wherein the condensed phosphate is at least one selected from tripolyphosphate, pyrophosphate and hexametaphosphate.
(C) The anionic surfactant is an acyl taurine salt, an acyl amino acid salt, an α-olefin sulfonate, an alkyl sulfo acetate, an alkenyl sulfo acetate, a polyoxyethylene alkyl ether phosphate and a polyoxyethylene alkenyl ether phosphorus. The oral composition according to any one of claims 1 to 5, which is one or more selected from the acid salts.
The oral composition according to any one of claims 1 to 6, which contains 0.0002 to 0.3% by mass of the component (D).
The oral composition according to any one of claims 1 to 7, which is a dentifrice, a mouthwash, a mouth spray, a coating agent or a patch.