JPH0269411A - Cosmetic composition - Google Patents

Abstract

PURPOSE:To obtain a cosmetic composition useful for dentifrice, etc., preventing reduction in residual ratio of active ingredient with time, containing an anionic surfactant, a tocopherol, alpha-bisabolol, glycyrrhizic acid, etc., packed in a specific container. CONSTITUTION:One or more of water-insoluble active ingredient of an anionic surfactant (e.g., sodium lauryl sulfate), a tocopherol or a derivative thereof, alpha-bisabolol, glycyrrhizic acid or a derivative thereof (beta-glycyrrhizic acid), cholesterol or a derivative thereof, hydroxamic acid or a derivative thereof, isopropylmethylphenol and hinokitiol are packed into a container comprising the innermost layer of barrel part and shoulder part made of a high-density polyethylene, polypropylene and low-density polyethylene crosslinked with a metal (e.g., Mg or Zn). The use of the container can prevent adsorption and absorption of the active ingredient in the container.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to the use of tocopherol and its derivatives, α-bisabolol, glycyrrhetinic acid and its derivatives, cholesterol and its derivatives, hydroxamic acid in the presence of an anionic surfactant. and its derivatives, isopropylmethylphenols, and hinokitiol, and relates to a cosmetic composition that prevents as much as possible a decrease in the residual rate over time.

Problems to be Addressed Conventionally, laminated films laminated with aluminum tubes, which have good airtightness and extrudability, have been commonly used as containers for toothpaste and other cosmetic compositions. This laminated film has its innermost layer made of low density polyethylene,
When an oral cavity composition is housed in a container made of the film, the oral cavity composition comes into contact with the innermost layer of low density polyethylene.

However, according to the studies conducted by the present inventors, an anionic surfactant, tocopherol and its derivatives, α-bisabolol, glycyrrhetinic acid and its derivatives, cholesterol and its derivatives, and hydroxamic acid were added to the container having the innermost layer of low-density polyethylene. When cosmetic compositions containing water-insoluble active ingredients such as and their derivatives, isopropylmethylphenols, and hinokitiol are stored, these active ingredients are adsorbed and absorbed by low-density polyethylene, and these active ingredients decrease during long-term storage. It was discovered that this problem arises.

In this case, such a problem does not occur in a system that does not contain an anionic surfactant, and the above-mentioned active ingredients are stably retained in a container whose innermost layer is low-density polyethylene, but anionic surfactants are usually essential for toothpaste etc. component, and removing the anionic surfactant will not solve the problem.

Various methods have been proposed to solve the problem of storing toothpaste, etc. in plastic containers (Japanese Patent Publication No. 11685/1985, Japanese Patent Publication No. 62-40).
No. 326, No. 63-2529.

JP-A-62-149671 and JP-A No. 62-161715) do not propose maintaining the stability of the above-mentioned active ingredients.

In order to solve the problem, the present inventors have developed an anionic surfactant, tocopherol and its derivatives, α-bisabolol,
Glycyrrhetinic acid and its derivatives.

In cosmetic compositions containing water-insoluble active ingredients selected from cholesterol and its derivatives, hydroxamic acid and its derivatives, isopropylmethylphenols, and hinokitiol, we are conducting intensive research on improving the storage stability of the above active ingredients. As a result, when the innermost layer of the body portion and/or B1 portion in contact with the composition is formed of high-density polyethylene, polypropylene, or low-density polyethylene crosslinked with metal as a container for accommodating this composition, the above-mentioned active ingredient It has been found that the adsorption and absorption of the ingredients into the container is prevented as much as possible, and the effects of the above-mentioned active ingredients are exhibited even after long-term storage.

The present invention will be explained in more detail below.

The cosmetic composition according to the present invention is made by using a combination of an anionic surfactant and a water-insoluble active ingredient, but the anionic surfactant can be selected depending on the type of the composition, the purpose of use, etc. Specifically, alkyl sulfate ester salts such as sodium lauryl sulfate and sodium myristyl sulfate.

Monoglyceride sulfate, alkyl ether sulfate.

Soap, ether carboxylate, acyl sarcosinate, acyl glutamate, α-olefin sulfonate,
Alkanesulfonate, dialkyl sulfosuccinate,
Acylaminosulfonate.

Examples include alkylaryl sulfonates, alkyl phosphate ester salts, polyoxyethylene alkyl ether phosphates, and one or more of these can be used. The amount of these anionic surfactants can be selected as appropriate, but is usually 0.1 to 5% (by weight) of the entire composition.
The same applies hereafter).

On the other hand, the water-insoluble active ingredients include one or two selected from tocopherol and its derivatives, α-bisabolol, glycyrrhetinic acid and its derivatives, cholesterol and its derivatives, hydroxamic acid and its derivatives, isopropylmethylphenols, and hinokitiol. The above is used.

Here, tocopherol derivatives include tocopherol acetate, tocopherol nicotinate, etc., glycyrrhetinic acid and its derivatives include β-glycyrrhetinic acid, stearyl glycyrrhetinate, etc., and cholesterol derivatives include dihydrocholesterol,
Examples include shrimp dihydrocholesterol. In addition, hydroxamic acid and its derivatives have the general formula R”-CH2C0
NHOH can be used, and its derivative is 2-(4-butoxyphenyl)acetohydroxa 11M
, 2-(4-methoxyphenyl)acetohydroxamic acid, caprylohydroxamic acid, laurohydroxamic acid, etc. can be used. Further, as the isopropylmethylphenol, isopropylmethylphenol (Biosol), thymol, carvacrol, etc. can be used.

The amount of these water-insoluble active ingredients is an effective amount and is not particularly limited, but in the case of α-bisabolol, it is 0.00
1-5%, especially 0.005-2%, in the case of tocopherols and their derivatives 0.001-2%, especially 0.01-2%
0.1%, 0 for glycyrrhetinic acid and its derivatives
．． 001-1%, especially 0.005-0.1%, 0.001-1%, especially 0.01-0.5% for cholesterol and its derivatives, o, ooi for hydroxamic acid and its derivatives ~1%, especially 0.01-0.5%, for isopropylmethylphenols 0.005-1
%, especially 0.01 to 0.1%, and in the case of hinokitiol, 0.001 to 1%, especially 0.005 to 0.1%.

In addition, other ingredients of the cosmetic composition of the present invention include:
Appropriate components can be used depending on the type of composition, etc. For example, in the case of toothpaste.

Dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate.

Abrasives such as amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, resin, carboxymethyl cellulose.

Hydroxyethylcellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol.

Binder such as polyacrylate, xanthan gum, thickening agent such as polyethylene glycol, sorbitol, glycerin, propylene glycol, saccharin sodium, stevioside, neohesberidyl dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, rest 6 Sweeteners and preservatives such as sulfuric acid and alkyl paraoxybenzoate, six families such as spearmint oil, carvone, and anethole can be blended.

In addition to the above-mentioned water-insoluble active ingredients, the cosmetic composition of the present invention also contains water-soluble active ingredients such as lysozyme chloride, allantoin, dextranase, mutanase,
Solved We element, chlorhexidine salt, sorbic acid, cetylpyridium chloride.

E-aminocaproic acid, tranexamic acid, sodium monofluorophosphate, sodium fluoride, stannous fluoride,
Water-soluble primary or secondary phosphates, quaternary ammonium compounds, 1-lium chloride, sodium polyphosphate, sodium hexametaphosphate.

Sodium orthophosphate, sodium copper chlorophyllin, etc. may be appropriately added.

The cosmetic composition of the present invention comprises the innermost layer of the torso and/or shoulders, more preferably the torso and shoulders, as described above,
The container is housed in a container in which the entire innermost layer in contact with the contents is made of high-density polyethylene, polypropylene, or low-density polyethylene crosslinked with metal.

Here, high density polyethylene has a density of 0.94 (g/cm
') The above-mentioned common materials are used, and also common polypropylene is used.

As the low-density polyethylene crosslinked with a metal, one using a divalent metal is preferable, and magnesium and zinc are particularly preferable.

There are no particular restrictions on the form of containers using the above materials, and various forms may be taken depending on the type and manner of use.

Examples include containers such as plastic laminated tubes, mechanical or differential pressure dispensers, film packaging containers such as pillow packaging, and bottles formed by injection, hollow, press, vacuum, or the like.

Here, plastic laminated tubes are particularly suitable, such as B15 tubes laminated with aluminum foil, in that they can prevent permeation of fragrances, etc. For example, starting from the outer layer,
Polypropylene, olefin resin, aluminum, olefin resin, polypropylene, etc. can be used.

Defects: The cosmetic composition of the present invention is housed in a container in which the innermost layer of the body and/or shoulders is made of high-density polyethylene, polypropylene, or low-density polyethylene cross-linked with metal. Tocopherol and its derivatives, α
- Bisabolol, glycyrrhetinic acid and its derivatives, cholesterol and its derivatives, hydroxamic acid and its derivatives.

Isopropylmethylphenols and hinokitiol are stably retained even in the presence of anionic surfactants,
The residual rate of the above-mentioned active ingredient does not decrease even if stored at high temperature for a long period of time.

EXAMPLES Next, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

[Examples 1 to 8. Comparative Examples 1 to 7] Toothpastes with the formulations shown in Table 1 using α-bisabolol, tocopherol acetate, isopropylmethylphenol, and tranexamic acid as active ingredients were prepared by a conventional method and filled into the following tubes A to D, respectively. After storing this at 50°C for one month, the residual rate of each active ingredient in the toothpaste was calculated. The results are also listed in Table 1.

Tube A: The body is made of polypropylene, aluminum foil, and polypropylene in order from the outer layer. The innermost layer of polypropylene had a thickness of 40 mm, and the tube shoulders were also made of the same polypropylene.

Tube B The layer structure of the body is made of high-density polyethylene, aluminum foil, and high-density polyethylene (density 0.94 g/■
3). The innermost layer of high-density polyethylene had a thickness of 40 μs, and the tube shoulders were also made of the same high-density polyethylene.

±;-B C The body has a layer structure consisting of low density polyethylene crosslinked with magnesium silane, aluminum foil, and low density polyethylene crosslinked with magnesium in order from the outer layer. The thickness of the innermost layer of low-density polyethylene cross-linked with magnesium is 4
The tube shoulder was also made of low density polyethylene cross-linked with the same magnesium.

Lazy You Uniboo P Bi" 1 ship p- = zub) The layer structure of the body is made of low density polyethylene, aluminum foil, aluminum foil,
Made of low density polyethylene (density 0.91g/■'). The thickness of the innermost layer of low density polyethylene is 40 μn
The tube shoulders were also made of the same low-density polyethylene.

In addition, in the results shown in Table 1, the analytical methods for α-bisabolol, vinegar m I-copherol, and isopropylmethylphenol are as follows.

After adding a barium chloride solution and hexane to α-bisabolol toothpaste and dispersing it, centrifugation is performed to obtain a hexane phase. Adipic acid di-n-butyl ester was added to the hexane phase as an internal standard, and complete failure was determined by gas chromatography.

After adding methanol to the active tocopherol 1'# powder and dispersing it, centrifugation was performed, and the supernatant liquid was quantified using liquid chromatography.

After adding a water-ethanol mixture to isopropyl methylphenol and dispersing it, centrifugation is performed, and the supernatant is collected. Acetonitrile was added to the supernatant liquid and the supernatant was subjected to r-filtration (0.45 μs), and then the r-liquid was quantified using a liquid chromatograph.

Calculation of the active ingredient residual rate is as follows.

A: The amount of the active ingredient at the initial stage of toothpaste preparation after storage at 50°C for one month. Also, the evaluation of the residual rate of the active ingredient is as follows.

0: Residual rate 90% or more Δ: Residual rate 80-90% ×: Residual rate less than 80% (*1) Fragrance composition Spearmint oil 0.8% Q-carvone 0.1 Anethole 0.08 Strawberry flavor 0.01 Ethanol 0.01 total
1.00% From the results in Table 1, when using a conventional container (container D) whose innermost layer is low-density polyethylene, the system without anionic surfactant (sodium lauryl sulfate) (comparative example 6) There is no adsorption of the active ingredient, and its residual rate is high even after long-term storage at high temperatures, and when water-soluble tranexamic acid is blended as the active ingredient (Comparative Example 7), anionic surfactant Even in systems containing water-insoluble α-bisabolol, tocopherol acetate, and isopropyl methylphenol, the residual rate of active ingredients was high after long-term storage at high temperatures. In (Comparative Examples 1 to 5), these active ingredients were adsorbed and the residual rate after long-term storage was reduced.

In contrast, when using tubes whose innermost layers were made of high-density polyethylene (tube B), polypropylene (tube A), and low-density polyethylene crosslinked with magnesium (tube C), respectively (Examples 1 to 8) Even in a system where anionic surfactants and water-insoluble active ingredients coexist, adsorption of these active ingredients is prevented as much as possible,
It was observed that the residual rate of the active ingredient was high after long-term storage.

[Example 9] Toothpaste zirconosilicate 25.0% silicic anhydride 2.0 Sorbiturate solution 40.0 Polyethylene glycol 400 5.0 Sodium polyacrylate 1.0 Sodium lauryl sulfate
1.5 Satucalin Sodium
0.2 Methyl paraoxybenzoate
0.2 Chlorhexidine gluconate 0.
05 Tocopherol acetate 0.1 Flavor 1.0 Purified ice
Remaining amount total
100.0% of this toothpaste was filled into the tube 8 described above.

[Example 101 Toothpaste Dibasic Calcium Phosphate 45.0% Silicic Anhydride 3.0 Sodium Carboxymethyl Cellulose 1.0 Carrageenan
0.2 sorbitol solution
18.0 Propylene glycol
2.0 Sodium alkyl sulfate (C1゜~C□s) 1.8 Sodium lauroyl sarcosinate 0.3 Sodium saccharin
0. 1 Sodium benzoate
0.3ε-aminocaprone rI! 0.05 β-glycyrrhetinic acid 0.1 Flavor
1.08 Total 100.0% This toothpaste was filled into the tube B mentioned above.

The composition below accounts for more than 98% of the total carbon number distribution.

C,,: O~20% C1□: 50~80% C14: 10~30% CL&: 0~15% [Example 11] Toothpaste Aluminum hydroxide 50.0% Glycerin 8.0 Sorbitol solution 15.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose Sodium lauryl sulfate
1.6 Saccharin Sodium 0
．． 2 Ethyl paraoxybenzoate 0.2 Sodium monofluorophosphate 0.76 Hinokitiol 0.1 Dihydrocholesterol 0.1 Flavor
1.0 water total 100.0%
This toothpaste was filled into the tube A described above.

[Example 12] Toothpaste neutralized aluminum hydroxide 42.0% silicic anhydride 2.5 glycerin 25°0 carrageenan
0.5 Sodium alginate
0.5 myristyl sodium sulfate
1.5 Satucalin Sodium
0.1 Methyl paraoxybenzoate 0.
1 myristic acid diethanolamide 0.3 dextranase 2 0 0 0 (u/
g) Thymol 0.2%
Chlorhexidine hydrochloride 0.01 Sodium monofluorophosphate 0.76 Flavor
1.0 Mizuhachi Total 100, 0% This ridge abrasion was filled into the tube C mentioned above.

[Example 13] Toothpaste zirconosilicate 20.0% glycerin 20.0 Sorbiturate solution 40.0 Propylene glycol 2.5 Sodium carboxymethyl cellulose 1.0 Gelatin
0.3 Anhydrous Kei M
1.0 titanium oxide
1. ON-Lauroyl taurate 1
．． Pentasodium diphytate 0.8 Sodium hydroxide 0. Stannous fluoride 0.41 Isopropylmethylphenol 0.05 Tocopherol acetate 0.1
1.0 Purified water total 100.0
% This toothpaste was filled into tube B described above.

[Example 14] Toothpaste aluminum-bonded silicate 25.0% silicic anhydride 2.0 sorbitol solution 40.0 polyethylene glycol 400 5.0 xanthan gum
0.5 Sodium alginate
0.5 Sodium lauryl FA acid
1.0 Satucalin Sodium
0.1 Methyl paraoxybenzoate
0.3 Butyl paraoxybenzoate 0.0
5 Chlorhexidine gluconate 0.05 Sodium polyphosphate 1.0 Carvacrol 0.05 Flavor
1.0 precision 4 total 100.
0% of this toothpaste was filled into the tube C described above.

[Example 15] Toothpaste calcium carbonate 45.0% anhydrous silicon 1 2.0 Sorbiturate solution 20.0 Sodium carboxymethylcellulose 1.5 Sodium lauryl sulfate 1.2 Sodium saccharin
0.1 Sodium benzoate
0.3 Sodium chloride
1.0 fragrance 1
0.0 Purified water total 100.0
% This toothpaste was placed in a pillow packaging container made of a laminated film consisting of cellophane, low-density polyethylene, aluminum foil, ethylene methacrylic acid copolymer, and polypropylene in order from the outer layer.

[Example 16] Toothpaste.

Dibasic calcium phosphate 45.0% sorbitol solution 20.0 Propylene glycol 3.0 Sodium carboxymethyl cellulose 1.0 Carrageenan
0.2 Sodium benzoate
0.3 Methyl paraoxybenzoate
0.2 silicic anhydride
2.5 Sodium lauryl sulfide
1.5 Satucalin Sodium 0.
2 Tranexam Wt O,05
α-Bisabolol 0.05 Flavor 1.0 Special water
Remaining amount total
Tube A described above was filled with 100.0% of this toothpaste.

[Example 17] Facial cleansing cream Coconut fatty acid triethanolamine 10% Sodium lauroyl sarcosinate 3 Potassium myristate 5 Sorbitan monolaurate 2 Liquid paraffin tocopherol acetate 0.2
Polyethylene glycol 1000 20 Propylene glycol 10 Fragrance
0.2 remaining total 100
．． 0% This facial cleansing cream was filled into the tube C mentioned above.

[Examples 18-20] The following tube E was filled with the toothpastes of Examples 1 to 3.

Tube E: A plastic laminate tube with a layered structure similar to Tube D (innermost layer is low-density polyethylene) described above, with a shoulder made of a polypropylene sheet so that the shoulder comes into contact with the contents.

[Examples 21 to 23] The following tube F was filled with the toothpastes of Examples 1 to 3.

Tube F A plastic laminate tube with the layered structure of Tube D (innermost layer is low density polyethylene), with a shoulder made of high density polyethylene (density 0.94 g/a&), and the shoulder comes into contact with the contents. That's what I did.

The cosmetic compositions of Examples 9 to 23 all have high residual rates of water-insoluble active ingredients after long-term storage at high temperatures.

Applicant: Laion Co., Ltd. Agent: Patent Attorney Takashi Kojima

Claims (1)

[Claims] 1. An anionic surfactant and one or more selected from tocopherol and its derivatives, α-bisabolol, glycyrrhetinic acid and its derivatives, cholesterol and its derivatives, hydroxamic acid and its derivatives, isopropylmethylphenols, and hinokitiol. and a water-insoluble active ingredient, and is housed in a container whose innermost layer of the body and/or shoulder is made of high-density polyethylene, polypropylene, or low-density polyethylene cross-linked with metal. cosmetic composition.