JPH04198121A - Composition for oral cavity - Google Patents
Composition for oral cavityInfo
- Publication number
- JPH04198121A JPH04198121A JP32711290A JP32711290A JPH04198121A JP H04198121 A JPH04198121 A JP H04198121A JP 32711290 A JP32711290 A JP 32711290A JP 32711290 A JP32711290 A JP 32711290A JP H04198121 A JPH04198121 A JP H04198121A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- sodium
- potassium
- inorganic salt
- hinokitiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 84
- 210000000214 mouth Anatomy 0.000 title abstract 3
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims abstract description 46
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims abstract description 32
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910017053 inorganic salt Inorganic materials 0.000 claims abstract description 23
- 229930007845 β-thujaplicin Natural products 0.000 claims abstract description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 18
- 229960002350 guaiazulen Drugs 0.000 claims abstract description 16
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 12
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 10
- 239000000057 synthetic resin Substances 0.000 claims abstract description 10
- 239000011780 sodium chloride Substances 0.000 claims abstract description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000001103 potassium chloride Substances 0.000 claims abstract description 4
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims abstract description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims abstract description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims abstract description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000011736 potassium bicarbonate Substances 0.000 claims abstract description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 claims abstract description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims abstract description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims abstract description 3
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims abstract description 3
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims abstract description 3
- 229910052939 potassium sulfate Inorganic materials 0.000 claims abstract description 3
- 235000011151 potassium sulphates Nutrition 0.000 claims abstract description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 claims abstract description 3
- 235000011152 sodium sulphate Nutrition 0.000 claims abstract description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 238000002156 mixing Methods 0.000 abstract description 9
- 239000004615 ingredient Substances 0.000 description 13
- 239000000606 toothpaste Substances 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 12
- -1 dipropylene Chemical compound 0.000 description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- 229960002216 methylparaben Drugs 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000004898 kneading Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 229940085605 saccharin sodium Drugs 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- ZCSHACFHMFHFKK-UHFFFAOYSA-N 2-methyl-1,3,5-trinitrobenzene;2,4,6-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)C1NC([N+]([O-])=O)NC([N+]([O-])=O)N1.CC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O ZCSHACFHMFHFKK-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229920003182 Surlyn® Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
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- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 235000005513 chalcones Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- AMCPECLBZPXAPB-UHFFFAOYSA-N propane-1,2,3-triol;sodium Chemical compound [Na].OCC(O)CO AMCPECLBZPXAPB-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、口腔用組成物、より詳しくはヒノキチオール
又はグアイアズレンのいずれか一方又は両方を含む口腔
用組成物に関する。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to an oral composition, and more particularly to an oral composition containing either hinokitiol or guaiazulene, or both.
（従来技術、発明が解決しようとする課題）近年、従来
の歯磨粉等の口腔用組成物の成分に、薬効成分、防腐剤
、安定化剤成分が添加された口腔用組成物が開発されて
おり、これにより口腔内の洗浄作用に加えて薬理作用が
付加された口腔用組成物、安定性に優れた口腔用組成物
等が提供されている。(Prior art, problem to be solved by the invention) In recent years, oral compositions have been developed in which medicinal ingredients, preservatives, and stabilizer ingredients are added to the ingredients of conventional oral compositions such as toothpaste. As a result, oral compositions with pharmacological effects in addition to oral cleaning effects, oral compositions with excellent stability, and the like have been provided.
しかしながら、ヒノキチオール又はグアイアズレンを含
有する組成物を、内面か合成樹脂よりなる容器に充填し
た場合、該成分が容器内面に吸着する等の理由により、
該成分の安定性が低下するという問題があった。However, when a composition containing hinokitiol or guaiazulene is filled into a container whose inner surface is made of synthetic resin, the component adsorbs to the inner surface of the container.
There was a problem that the stability of the component decreased.
本発明者らは、かかる問題を解決すべく、内面が合成樹
脂よりなる容器に充填した場合にも高い安定性が保持さ
れるヒノキチオール又はグアイアグレン含有口腔用組成
物を得るため、鋭意研究を重ねた結果、従来の口腔用組
成物成分及びヒノキチオール又はグアイアズレンからな
る口腔用組成物に、さらに水易溶性無機塩を添加するこ
とにより、ヒノキチオール又はグアイアズレンの安定性
が著しく向上することを見出した。In order to solve this problem, the present inventors conducted extensive research in order to obtain an oral composition containing hinokitiol or guaiagrain that maintains high stability even when filled into a container whose inner surface is made of synthetic resin. As a result, it has been found that the stability of hinokitiol or guaiazulene can be significantly improved by further adding a water-soluble inorganic salt to an oral composition consisting of conventional oral composition components and hinokitiol or guaiazulene.
（課題を解決するための手段）
従って、本発明は、ヒノキチオール若しくはグアイアズ
レンのいずれか一方又はその両方（以下、ヒノキチオー
ル等と記載する）を含有する、合成樹脂製の内面を有す
る容器に充填された口腔用組成物であって、該口腔用組
成物がさらに１種類又はそれ以上の水易溶性無機塩を含
有することを特徴とする口腔用組成物に関する。(Means for Solving the Problems) Therefore, the present invention provides a container having an inner surface made of a synthetic resin, which contains either hinokitiol or guaiazulene, or both (hereinafter referred to as hinokitiol, etc.). The present invention relates to an oral composition characterized in that the oral composition further contains one or more water-soluble inorganic salts.
前記水易溶性無機塩は、好ましくは塩化ナトＩＪウム、
塩化カリウム、炭酸水素ナトリウム、炭酸ナトリウム、
炭酸水素カリウム、炭酸カリウム、リン酸一水素ナトリ
ウム、リン酸二水素ナトリウム、リン酸一水素カリウム
、リン酸二水素カリウム、硫酸ナトリウム及び硫酸カリ
ウムからなる群から選ばれる１種類又はそれ以上の化合
物である。The easily water-soluble inorganic salt is preferably sodium chloride,
Potassium chloride, sodium bicarbonate, sodium carbonate,
One or more compounds selected from the group consisting of potassium hydrogen carbonate, potassium carbonate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, potassium monohydrogen phosphate, potassium dihydrogen phosphate, sodium sulfate, and potassium sulfate. be.
水易溶性無機塩は、口腔用組成物全量に対して、通常０
．１〜５０重量％、好ましくは０．５重量％〜５０重量
％の量で添加する。これは、 ０．１重量％未満の添加
量では充分な安定化効果が得られず、また５０重量％を
超えると製剤上の困難を生じるからである。以下、本明
細書において、％は全で重量基準による。The water-soluble inorganic salt is usually 0% based on the total amount of the oral composition.
．． It is added in an amount of 1 to 50% by weight, preferably 0.5% to 50% by weight. This is because if the amount added is less than 0.1% by weight, a sufficient stabilizing effect cannot be obtained, and if it exceeds 50% by weight, difficulties arise in formulation. Hereinafter, in this specification, all percentages are based on weight.
ヒノキチオール等の含有量は、通常０．００１〜１％で
ある。The content of hinokitiol etc. is usually 0.001 to 1%.
水易溶性無機塩及びヒノキチオール等以外の成分として
は、従来普通に使用されている歯磨基材を使用すること
ができる。As components other than the easily water-soluble inorganic salt, hinokitiol, etc., conventionally used toothpaste base materials can be used.
これらの歯磨基材の具体例及びその通常の配合量を以下
に示す。Specific examples of these dentifrice base materials and their usual blending amounts are shown below.
配合量
保湿剤 グリセリン、ソルビトール、 １０〜４０％プ
ロピレングリコール、
ポリエチレングリコール、
キシリトール、ジプロピレン、
クリコール、乳酸ナトリウム、
マルチトール等
研磨剤 ピロリン酸カルシウム、無水 １０〜５０％ケ
イ酸、水酸化アルミニウム、
リン酸水素カルシウム、炭酸
カルシウム、結晶セルロース
等
発泡剤 ラウリル硫酸ナトリウム、 ０．１〜５％ド
デシルベンゼンスルホン酸
ナトリウム、ラウリルスルホ
酢酸ナトリウム、Ｎ−ラウロ
イルサルコシンナトリウム、
ショ糖脂肪酸エステル、ポリ
オキシエチレンソルビタン、
ポリオキシエチレンノニルフ
二二ルエーテル、アルキロ−
ルアミド、両性界面活性剤等
粘結剤 カルボキシメチルセルロース ０．１〜５％ナ
トリウム、ヒドロキシエチ
ルセルロース、アルギン酸塩、
カラギーナン、アラビアコム、
ポリビニルアルコール、メチ
ルセルロース等
甘味剤 サッカリンナトリウム、ステ ０．１〜３％ビ
オサイド、グリチルリチン、
カルコン、ジヒドロカルコン
等
防腐剤 パラオキシ安息香酸エステル０．０１〜０．１
％類等
香料 ペパーミント、スペアミント０．Ｏ１〜２．０
％等の精油、ｌ−メントール等
本発明の口腔用組成物にはまた、塩化リゾチーム、デキ
ストラナーゼ、溶菌酵素、ムタナーセ、クロルヘキシジ
ン、ソルビン酸、セチルピリジニウムクロライド、塩化
ナトリウム、アラントイン、ε−アミノカプロン酸、ト
ラネキサム酸、アズレン、フッ化ナトリウム、モノフル
オロリン酸ナトリウム等のフッ化物、乳酸アルミニウム
、エデト酸塩、色素、ＢＨＴ、イソプロピルメチルフェ
ノール、酢酸トコフェロール、エビジヒドロコレステリ
ン等の有効成分を含有させることができる。Moisturizing agent Glycerin, sorbitol, 10-40% propylene glycol, polyethylene glycol, xylitol, dipropylene, glycol, sodium lactate, maltitol, etc. Abrasives Calcium pyrophosphate, anhydrous 10-50% silicic acid, aluminum hydroxide, phosphoric acid Foaming agents such as calcium hydrogen, calcium carbonate, crystalline cellulose, sodium lauryl sulfate, 0.1-5% sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauroylsarcosine, sucrose fatty acid ester, polyoxyethylene sorbitan, polyoxy Binder such as ethylene nonyl phenyl ether, alkylamide, amphoteric surfactant, etc. Carboxymethyl cellulose 0.1-5% sodium, hydroxyethyl cellulose, alginate, carrageenan, arabicum, polyvinyl alcohol, methyl cellulose, etc. Sweeteners Sodium saccharin, ester 0.1-3% Biocide, glycyrrhizin, chalcone, dihydrochalcone, etc. preservatives paraoxybenzoic acid ester 0.01-0.1
%Fragrances Peppermint, Spearmint 0. O1~2.0
% essential oil, l-menthol, etc. The oral composition of the present invention also contains lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine, sorbic acid, cetylpyridinium chloride, sodium chloride, allantoin, ε-aminocaproic acid. , tranexamic acid, azulene, sodium fluoride, fluorides such as sodium monofluorophosphate, aluminum lactate, edetate, pigments, BHT, isopropylmethylphenol, tocopherol acetate, evidihydrocholesterin, and other active ingredients. I can do it.
本発明の口腔用組成物を充填する容器は、少なくとも内
面が合成樹脂により形成されている容器である。合成樹
脂としては、例えばポリエチレン、サーリン、ＰＰ、Ｐ
ＶＣ，ＰＥＴ、ナイロン等か使用される。The container filled with the oral composition of the present invention is a container whose at least the inner surface is made of synthetic resin. Examples of synthetic resins include polyethylene, Surlyn, PP, and P.
VC, PET, nylon, etc. are used.
本発明の口腔用組成物は、練歯磨、粉歯磨、水歯磨等の
いす′れの形態でもありうる。The oral composition of the present invention may also be in the form of a toothpaste, powdered toothpaste, water toothpaste, or the like.
（作用）
本発明の水易溶性無機塩を含有する口腔用組成物により
、内面が合成樹脂により形成された容器内においても、
ヒノキチオール及びグアイアズレンの容器内面への吸着
等による安定性の低下を防止することができ、結果とし
て該容器内において安定性の向上した口腔用組成物を提
供することができる。(Effect) The oral composition containing the easily water-soluble inorganic salt of the present invention can be used even in a container whose inner surface is made of synthetic resin.
It is possible to prevent a decrease in stability due to adsorption of hinokitiol and guaiazulene to the inner surface of the container, and as a result, it is possible to provide an oral composition with improved stability within the container.
（実施例）
実施例１：各々下記の組成に示す成分を混合することに
より、組成物ＡＩ、組成物Ｂ１及び組成物Ｃ１を製造し
、その後これらを混練することにより口腔用組成物（練
歯磨）を製造した。なお、組成は口腔用組成物全量に対
する割合（％）として示した。(Example) Example 1: Composition AI, Composition B1, and Composition C1 were produced by mixing the components shown in the following compositions, and then an oral composition (toothpaste) was prepared by kneading these. ) was manufactured. In addition, the composition was shown as a ratio (%) to the total amount of the oral composition.
組成物ＡＩ
成分 ％
歯磨用リン酸水素カルシウム ５０．０ラウリル
硫酸ナトリウム １．０塩化ナトリウム
５．０組成物Ｂｌ
成分 ％
グリセリン ２０．０アラントイン
０．１サツカリンナトリウム
０．０５精製水
２２．５５組成物Ｃ１
成分 ％
ヒノキチオール ０，１メチルパ
ラベン ０．２香料
１．０実施例２：各々下記の組成
に示す成分を混合することにより、組成物Ａ２、組成物
Ｂ２及び組成物ｃ２を製造し、その後これらを混練する
ことにより口腔用組成物（練歯磨）を製造した。なお、
組成は口腔用組成物全量に対する割合（％）として示し
た。Composition AI Ingredients % Calcium hydrogen phosphate for toothpaste 50.0 Sodium lauryl sulfate 1.0 Sodium chloride
5.0 Composition Bl Ingredients % Glycerin 20.0 Allantoin 0.1 Saccharin sodium 0.05 Purified water
22.55 Composition C1 Ingredients % Hinokitiol 0.1 Methylparaben 0.2 Fragrance
1.0 Example 2: Composition A2, Composition B2, and Composition C2 are manufactured by mixing the components shown in the following compositions, and then an oral composition (toothpaste) is prepared by kneading these. was manufactured. In addition,
The composition was shown as a percentage (%) of the total amount of the oral composition.
組成物Ａ２
成分 ％
炭酸カルシウム ３８．０ラウリル
硫酸ナトリウム １．５炭酸水素ナトリウ
ム １０．０組成物Ｂ２
社 ％
グリセリン ２５．０カラギーナ
ン １．２サツカリンナトリウ
ム ０．１グリチルリチン酸
０．１精製水
２３．０５組成物Ｃ２
成分 ％
グアイアズレン ０．０５メチル
パラベン ０．１プロピルパラベ
ン ０．１香料
０．８実施例３：各々下記の組成に示す
成分を混合することにより、組成物Ａ及び組成物Ｂを製
造し、その後これらを混合することにより口腔用組成物
（水歯磨）を製造した。なお、組成は口腔用組成物全量
に対する割合（％）として示した。Composition A2 Ingredients % Calcium carbonate 38.0 Sodium lauryl sulfate 1.5 Sodium hydrogen carbonate 10.0 Composition B2 Company % Glycerin 25.0 Carrageenan 1.2 Sodium saccharin 0.1 Glycyrrhizic acid
0.1 purified water
23.05 Composition C2 Ingredients % Guaiazulene 0.05 Methylparaben 0.1 Propylparaben 0.1 Fragrance
0.8 Example 3: Composition A and Composition B were manufactured by mixing the components shown in the following compositions, and then an oral composition (water toothpaste) was manufactured by mixing these. In addition, the composition was shown as a ratio (%) to the total amount of the oral composition.
組成物Ａ３ 成分 ％ エターノル ６．ｏ。Composition A3 Ingredients % Eternor 6. o.
メチルパラベン ０．１ヒノキチ
オール ０．０５香料
０．２組成物Ｂ３
成分 ％
サッカリンナトリウム ０．０３ソル
ビツト液 ５．０塩化カリウ
ム １．０精製水
８５．６２実施例４：各々下記の組成
に示す成分を混合することにより、組成物Ａ４、組成物
Ｂ４及び組成物Ｃ４を製造し、その後これらを混練する
ことにより口腔用組成物（練歯磨）を製造した。なお、
組成は口腔用組成物全量に対する割合（％）として示し
た。Methylparaben 0.1 Hinokitiol 0.05 Fragrance
0.2 Composition B3 Ingredients % Saccharin sodium 0.03 Sorbiturate solution 5.0 Potassium chloride 1.0 Purified water
85.62 Example 4: Composition A4, Composition B4, and Composition C4 are prepared by mixing the components shown in the following compositions, and then an oral composition (toothpaste) is prepared by kneading these. was manufactured. In addition,
The composition was shown as a percentage (%) of the total amount of the oral composition.
組成物Ａ４
社 ％
塩化ナトリウム １０．０無水ケイ
酸 ２０．０ラウリル硫酸ナト
リウム ２．０組成物Ｂ４
弐分 ％
カルホキジメチルセルロース １．０ナトリウ
ム
グリセリン ２０．０サツカリン
ナトリウム ０．０５精製水
４５．６２組成物Ｃ４
成分 ％
グアイアズレン ０．０３酢酸ト
コフエロール ０．２メチルパラベン
０．１香料
１．０試験例１：
各々下記の組成に示す成分を混合することにより、組成
物Ａ５、組成物Ｂ５及び組成物Ｃ５を製造し、その後こ
れらを混合することにより口腔用組成物（練歯磨）を製
造した。なお、組成は口腔用組成物全量に対する割合（
％）として示した。Composition A4 Company % Sodium chloride 10.0 Silicic anhydride 20.0 Sodium lauryl sulfate 2.0 Composition B4 2% Calphoki dimethylcellulose 1.0 Sodium glycerin 20.0 Sodium saccharin 0.05 Purified water
45.62 Composition C4 Ingredients % Guaiazulene 0.03 Tocopheryl acetate 0.2 Methylparaben 0.1 Fragrance
1.0 Test Example 1: Composition A5, Composition B5, and Composition C5 are manufactured by mixing the components shown in the following compositions, and then an oral composition (toothpaste) is prepared by mixing these. was manufactured. The composition is expressed as a percentage of the total amount of the oral composition (
%).
組成物Ａ５
成分 ％
水易溶性無機塩 Ｘリン酸水素
カルシウム ４５−Ｘラウリル硫酸ナトリ
ウム １．５０組成物Ｂ５
成分 ％
グリセリン ２０．００サツカリ
ンナトリウム ０．１０塩酸アルキル
ジアミノエチル ０．１０グリシン
精製水 ３１．０５組成物
Ｃ５
成分 ％
ヒノキチオール ０．０５香料
１．００上記組成中、
水易溶性無機塩は塩化す） ＩＪウム又はリン酸二水素
ナトリウムであり、Ｘは下記の表に示す水易溶性無機塩
の含有量（％）である。Composition A5 Ingredients % Water-soluble inorganic salt .05 Composition C5 Ingredients % Hinokitiol 0.05 Fragrance
1.00 in the above composition,
The easily water-soluble inorganic salt is chlorinated) or sodium dihydrogen phosphate, and X is the content (%) of the easily water-soluble inorganic salt shown in the table below.
上記で製造された口腔用組成物２０ｇを内面がポリエチ
レンよりなる容器に充填し、５０°Ｃで１か月保存した
。保存後のヒノキチオールの残存率を製造直後のヒノキ
チオールの含有量に対する含有量の割合（％）として求
め、これを安定性の指標とした。即ち、残存率か高い程
、安定性が高いことを示す。20 g of the oral composition produced above was filled into a container whose inner surface was made of polyethylene, and stored at 50°C for one month. The residual rate of hinokitiol after storage was determined as a content ratio (%) to the hinokitiol content immediately after production, and this was used as an index of stability. That is, the higher the residual rate, the higher the stability.
水易溶性無機塩：塩化ナトリウム
添加量（％）０ ０．１ ０．５ １ ５ １０
残存率（％） ５０．２ ６８．５ ９０．３ ９８
．４ ９９．５ ９９．ε水易溶性無機塩ニリン酸二水
素ナトリウム添加量（％） ＯＯ，１０，５１５１０
残存率（％） −８０，３９５，４９９，３９９，８
９９，７表より、水易溶性無機塩の添加により、安定性
が向上し、特に１％以上の添加では著しい向上が達成さ
れることが明らかである。Easily water-soluble inorganic salt: added amount of sodium chloride (%) 0 0.1 0.5 1 5 10
Survival rate (%) 50.2 68.5 90.3 98
．． 4 99.5 99. ε Amount of water-soluble inorganic salt sodium dihydrogen diphosphate added (%) OO, 10,51510
Survival rate (%) -80,395,499,399,8
It is clear from Table 99.7 that the stability is improved by the addition of a water-soluble inorganic salt, and in particular, a significant improvement is achieved when 1% or more is added.
試験例２：
水易溶性無機塩として下記の化合物を使用し、その添加
量を５％とすること以外は、試験例１と同様の方法によ
り、口腔用組成物の安定性を試験した。Test Example 2: The stability of the oral composition was tested in the same manner as Test Example 1, except that the following compound was used as the easily water-soluble inorganic salt and the amount added was 5%.
結果を下記の表に示す。The results are shown in the table below.
ヒノキチオール０．０５％をグアイアズレン０．０５％
に変えること以外は、試験例１と同様の方法により安定
性を試験した。Hinokitiol 0.05% Guaiazulene 0.05%
Stability was tested in the same manner as in Test Example 1, except for changing to .
結果を下記の表に示す。The results are shown in the table below.
水易溶性無機塩：塩化ナトリウム
添加量（％） ０ ０．１ ０．５ １ ５
１０残存率（％）４５．３ ６０．’３ ８５．１ ９
２．４ ９５．３ ９９．４水易溶性熱機塩・リン酸二
水素ナトリウム添加量（％） ＯＯ，１０，５１５１
０残存率（％） −７６，６８５，１９１，０９３，
９９６，５表より、水易溶性無機塩の添加により、安定
性が向上し、特に１％以上の添加では著しい向上が達成
されることが明らかである。Easily water-soluble inorganic salt: Added amount of sodium chloride (%) 0 0.1 0.5 1 5
10 Survival rate (%) 45.3 60. '3 85.1 9
2.4 95.3 99.4 Addition amount of easily water-soluble thermal salt/sodium dihydrogen phosphate (%) OO, 10,5151
0 remaining rate (%) -76,685,191,093,
From Table 996.5, it is clear that the addition of a readily water-soluble inorganic salt improves the stability, and in particular, when 1% or more is added, a significant improvement is achieved.
試験例４：
ヒノキチオール０．０５％をグアイアズレン０．０５％
に変え、水易溶性無機塩として下記の化合物を使用し、
その添加量を５％とすること以外は、試験例１と同様の
方法により、口腔用組成物の安定性を試験した。Test example 4: Hinokitiol 0.05% and guaiazulene 0.05%
Instead, use the following compound as a water-soluble inorganic salt,
The stability of the oral composition was tested in the same manner as Test Example 1 except that the amount added was 5%.
結果を下記の表に示す。The results are shown in the table below.
無機塩 炭酸水素 炭酸ナト 炭酸水素 炭酸カリナト
リウ リウム カリウム ラム
！、
試験例５：
試験例１の組成において水易溶性無機塩として塩化ナト
リウム１０重量％を使用した口腔用組成物及び水易溶性
無機塩を添加しなかった口腔用組成物を、下記の表に示
す合成樹脂により内面が形成された容器中に入れ、試験
例１と同様の方法により安定性を試験した。結果を下記
の表に示す。Inorganic salts hydrogen carbonate sodium carbonate hydrogen carbonate potassium carbonate potassium rum! , Test Example 5: An oral composition using 10% by weight of sodium chloride as a water-soluble inorganic salt in the composition of Test Example 1 and an oral composition to which no water-soluble inorganic salt was added are shown in the table below. The product was placed in a container whose inner surface was made of the synthetic resin shown below, and the stability was tested in the same manner as in Test Example 1. The results are shown in the table below.
Ｐ Ｐ ９８．７ ６０．３ＰＶＣ９９，４
６５，３
ＰＥＴ ９９．４ ６８．９
ナイロン ９８．７ ５１．３
試験例６：
ヒノキチオールの代わりにグアイアズレン０，０５重量
％を使用すること以外は試験例３と同様の方法により安
定性を試験した。結果を下記の表に示す。P P 98.7 60.3PVC99,4
65,3 PET 99.4 68.9 Nylon 98.7 51.3 Test Example 6: Stability was tested in the same manner as Test Example 3 except that 0.05% by weight of guaiazulene was used instead of hinokitiol. . The results are shown in the table below.
ＰＰ ９８．６ ５７．５
ＰＶＣ９９，１６０，１
ＰＥＴ ９９．４ ６５．２
ナイロン ９８．５ ５５．３
（発明の効果）
本発明の口腔用組成物は、ヒノキチオール及びグアイア
ズレンの油溶性成分及び通常の歯磨基材に加えて、水易
溶性無機塩を含むため、合成樹脂性の内面を有する容器
中でも安定性が高い。従って、本発明により油溶性成分
の有効性が持続し、また長期間保存された後にも変質等
を生じにくい口腔用組成物を提供することが可能になる
。PP 98.6 57.5 PVC99,160,1 PET 99.4 65.2 Nylon 98.5 55.3 (Effect of the invention) The oral composition of the present invention contains oil-soluble components of hinokitiol and guaiazulene and ordinary In addition to the toothpaste base material, it contains a water-soluble inorganic salt, so it is highly stable even in containers with a synthetic resin inner surface. Therefore, according to the present invention, it is possible to provide an oral composition in which the effectiveness of the oil-soluble component is sustained and which is less susceptible to deterioration even after being stored for a long period of time.
Claims (2)
か一方又はその両方を含有する、合成樹脂製の内面を有
する容器に充填された口腔用組成物であって、該口腔用
組成物がさらに１種類又はそれ以上の水易溶性無機塩を
含有することを特徴とする口腔用組成物。(1) An oral composition containing either hinokitiol or guaiazulene, or both, filled in a container having an inner surface made of a synthetic resin, the oral composition further containing one or more types of An oral composition characterized by containing a readily water-soluble inorganic salt.
リウム、炭酸水素ナトリウム、炭酸ナトリウム、炭酸水
素カリウム、炭酸カリウム、リン酸一水素ナトリウム、
リン酸二水素ナトリウム、リン酸一水素カリウム、リン
酸二水素カリウム、硫酸ナトリウム及び硫酸カリウムか
らなる群から選ばれる１種類又はそれ以上の化合物であ
ることを特徴とする請求項（１）記載の口腔用組成物。(2) The easily water-soluble inorganic salt is sodium chloride, potassium chloride, sodium hydrogen carbonate, sodium carbonate, potassium hydrogen carbonate, potassium carbonate, sodium monohydrogen phosphate,
Claim (1), characterized in that it is one or more compounds selected from the group consisting of sodium dihydrogen phosphate, potassium monohydrogen phosphate, potassium dihydrogen phosphate, sodium sulfate, and potassium sulfate. Oral composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2327112A JP3036829B2 (en) | 1990-11-28 | 1990-11-28 | Oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2327112A JP3036829B2 (en) | 1990-11-28 | 1990-11-28 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04198121A true JPH04198121A (en) | 1992-07-17 |
| JP3036829B2 JP3036829B2 (en) | 2000-04-24 |
Family
ID=18195431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2327112A Expired - Fee Related JP3036829B2 (en) | 1990-11-28 | 1990-11-28 | Oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3036829B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002020253A (en) * | 2000-07-05 | 2002-01-23 | Kobayashi Pharmaceut Co Ltd | Composition for oral use |
| FR2838643A1 (en) * | 2002-04-23 | 2003-10-24 | Farmaceutici S R L | A non-abrasive whitening toothpaste composition comprises a specified amount of sea water |
| US6689342B1 (en) | 2002-07-29 | 2004-02-10 | Warner-Lambert Company | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same |
| US6787675B2 (en) | 2002-07-29 | 2004-09-07 | Warner-Lambert Company | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same |
| JP2007001884A (en) * | 2005-06-21 | 2007-01-11 | Toa Yakuhin Kk | Liquid medicine containing guaiazulenesulfonate salt |
-
1990
- 1990-11-28 JP JP2327112A patent/JP3036829B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002020253A (en) * | 2000-07-05 | 2002-01-23 | Kobayashi Pharmaceut Co Ltd | Composition for oral use |
| FR2838643A1 (en) * | 2002-04-23 | 2003-10-24 | Farmaceutici S R L | A non-abrasive whitening toothpaste composition comprises a specified amount of sea water |
| US6689342B1 (en) | 2002-07-29 | 2004-02-10 | Warner-Lambert Company | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same |
| US6787675B2 (en) | 2002-07-29 | 2004-09-07 | Warner-Lambert Company | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same |
| US6924398B2 (en) | 2002-07-29 | 2005-08-02 | Warner-Lambert Company Llc | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same |
| JP2007001884A (en) * | 2005-06-21 | 2007-01-11 | Toa Yakuhin Kk | Liquid medicine containing guaiazulenesulfonate salt |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3036829B2 (en) | 2000-04-24 |
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