CN102573769A

CN102573769A - Dentifrice composition

Info

Publication number: CN102573769A
Application number: CN2010800429267A
Authority: CN
Inventors: 山本幸司; 平山隆; 天野步
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2009-11-06
Filing date: 2010-11-01
Publication date: 2012-07-11
Anticipated expiration: 2030-11-01
Also published as: JP5597969B2; JP2011098918A; CN102573769B; WO2011055707A1; HK1172251A1

Abstract

Disclosed is a dentifrice composition which exhibits high local retention properties for a preparation in the oral cavity, while having an excellent bactericidal effect on oral biofilms. The dentifrice composition has a flavor that is almost free from unpleasant taste and excellent feeling of use, while being suppressed in stickiness. Specifically disclosed is a dentifrice composition which is characterized by containing (A) isopropyl methyl phenol, (B) at least one fragrance material selected from among 3-octanol, 3-octyl acetate, 3-octanone and fenchone, (C) sorbit, (D) glycerin and (E) a polyethylene glycol that has an average molecular weight of 280-9,300. The dentifrice composition additionally contains (F) anisaldehyde.

Description

Dentrifice composition

Technical field

The present invention relates to high, the oral biological film sterilizing power excellence of preparation anelasticity in the oral cavity, and the Dentrifice composition that abnormal flavour is few, the viscous sense is few, usability is excellent.

Background technology

It is generally acknowledged that dental caries, this two big oral disease of periodontal disease are because various bacterial in the biomembrane in the oral cavity.Especially; Dental caries is that streptococcus, the periodontal disease of Streptococcus mutans (S.mutans) etc. is to be main bacterial infection disease by porphyromonas gingivalis obligate anaerobic gram negative bacilli such as (P.gingivalis); In addition, the reason of halitosis is relevant with Fusobacterium nucleatum oral cavity bacteriums such as (F.nucleatum).Therefore, it is said as the prevention of illness in the oral cavity, improve effective means, pathogenic bacteria number in the biomembrane in the oral cavity is remained on low-level comparatively useful.

On the other hand, in order to reduce intraoral pathogenic bacteria number, use slightly water-soluble antibacterial or cationic antibacterial, anionic antibacterial effective, especially, to biomembranous antibacterial, the suitable isopropyl methyl phenol (patent documentation 1 that uses; Japanese Patent Laid is opened 2005-179266 communique, patent documentation 2; Japanese Patent Laid is opened the 2006-182662 communique).

The known isopropyl methyl phenol of killing the inner pathogenic bacteria of biomembrane that is applicable to, its impregnability in biomembrane is more excellent than other sterilization components.But, have distinctive abnormal flavour owing to contain the compositions of isopropyl methyl phenol, produce the significantly shortcoming of infringement usability, need improve this point.

To above-mentioned problem, for example proposed, through in phenyl phenol with the specific acyl sarcosinates of specific mixed, reduce the technology (patent documentation 3 of the abnormal flavour of antimicrobial component; Japanese Patent Laid is opened the 2007-161613 communique), through in isopropyl methyl phenol with specific mass ratio mixings 1-menthol and sodium chloride, the technology (patent documentation 4 of reduction foreign odor, abnormal flavour; Japanese Patent Laid is opened the 2008-143825 communique).But when mixing more acyl sarcosinates, producing the oral mucosa that is considered to from acyl sarcosinates sometimes stimulates, and in addition, produces during mixed chlorinated sodium because saline taste, and the type of fragrance such as is limited at new problem, and usability also is far from being satisfactory.

In addition, though the method for covering and reduce abnormal flavour through sweeting agents such as glucide is also arranged, this moment, the taste of sweeting agent may not be talked too strongly can suppress abnormal flavour.Therefore, seek to reduce new technique from the abnormal flavour of isopropyl methyl phenol.

And then, in order effectively to kill the inner pathogenic bacteria of biomembrane, when making isopropyl methyl phenol, be necessary to improve to the inner impregnability of biomembrane with the high concentration topical effect.But Dentrifice composition in the past, preparation be internal diffusion owing to dispersibility and in the oral cavity, is difficult to keep medicament satisfactorily here with high concentration.

As improving the technology of isopropyl methyl phenol mix preparation in intraoral anelasticity, the someone proposes to mix the method (patent documentation 5 of specific polyoxyethylene (POE) hardened castor oil and tackifying silicon dioxide; Japanese Patent Laid is opened the 2009-96747 communique).But this technology only limits to not mix the dentifrice of the pickling agent with abrasiveness, in addition, produces the distinctive abnormal flavour of anionic surfactant sometimes, aspect usability, has also left over problem.

As method that can the effective supply sterilization component, the someone proposes to contain the collagen film of sterilization component or the adhesive preparation (patent documentation 6 that the collagen protein sheet is attached to tooth surface; Japanese Patent Laid is opened 2006-182705 communique, patent documentation 7; Japanese Patent Laid is opened the 2007-182705 communique).But, the bactericidal effect that the biomembrane that has used this attaching dosage form method for compositions to be difficult to improve to be present between teeth space and tooth and the gingiva is inner.

On the other hand, Sorbitol, glycerol, Polyethylene Glycol usually all as wetting agent to prevent exsiccant purpose and to keep the good purpose of outward appearance etc. to be blended in (patent documentation 8 in the Dentrifice composition; No. 3959636 communique of Japan Patent).But therefore these wetting agents, also exist the problem of usability variation because its viscosity coca increases, produces the viscous sense according to the stringiness of the different preparations of combined amount.

Like this; Isopropyl methyl phenol is because excellent to the biomembranous impregnability in oral cavity; Sterilization component as Dentrifice composition is useful; But in Dentrifice composition, mix isopropyl methyl phenol, and do not damage usability, make it be trapped in satisfactorily in the oral cavity in, bring into play high biological film sterilizing effect, these for prior art all be difficult, be difficult to practicability.Therefore, the oral biological film bactericidal effect that preparation not only is excellent in intraoral anelasticity, performance is high is developed in expectation, and abnormal flavour and the viscous sense is few, usability is excellent Dentrifice composition.

The prior art document

Patent documentation

[patent documentation 1] Japanese Patent Laid is opened the 2005-179266 communique

[patent documentation 2] Japanese Patent Laid is opened the 2006-182662 communique

[patent documentation 3] Japanese Patent Laid is opened the 2007-161613 communique

[patent documentation 4] Japanese Patent Laid is opened the 2008-143825 communique

[patent documentation 5] Japanese Patent Laid is opened the 2009-96747 communique

[patent documentation 6] Japanese Patent Laid is opened the 2006-182705 communique

[patent documentation 7] Japanese Patent Laid is opened the 2007-182705 communique

No. 3959636 communique of [patent documentation 8] Japan Patent

Summary of the invention

The present invention In view of the foregoing forms, and purpose is to provide that a kind of not only preparation is excellent in intraoral anelasticity, the oral biological film sterilizing power is excellent, and abnormal flavour and the viscous sense is few, usability is excellent Dentrifice composition.

The people is for achieving the above object in invention; Make great efforts research repeatedly; The result finds: having mixed the fragrance component more than a kind, (C) Sorbitol, (D) glycerol, (E) mean molecule quantity that (A) isopropyl methyl phenol, (B) be selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone is 280～9; The Dentrifice composition of 300 Polyethylene Glycol, against expectation, the sterilizing power that preparation is high in intraoral anelasticity, biomembrane is inner is excellent; And abnormal flavour is few, the viscous sense also less, usability is excellent, and accomplished the present invention.

Among the present invention, be under the existence of 280～9,300 Polyethylene Glycol at mean molecule quantity; The bactericidal action that isopropyl methyl phenol has is effectively brought into play in biomembrane inside, simultaneously, and then because also with Sorbitol and glycerol; Not only preparation improves in intraoral anelasticity, can effectively bring into play bactericidal action, the viscous sense of inhibitory preparation; And; Through in isopropyl methyl phenol and with mixing specific fragrance component, suppress generation from the distinctive abnormal flavour of the composition that cleans the teeth, make it have good fragrance.

Therefore; According to the present invention; Through in the Dentrifice composition that contains (A) isopropyl methyl phenol, mixing the specific spice of (B) composition; And and with (C)～(E) composition, the various problems in the past that can achieve a solution, suppressed to make from the viscous sense of the abnormal flavour of isopropyl methyl phenol and preparation, not damaging usability preparation in the oral cavity, be detained, bring into play high biological film sterilizing effect satisfactorily, have concurrently excellent sterilizing effect and usability to the prevention of oral diseases such as periodontal disease or improve effective Dentrifice composition.

The fragrance component of above-mentioned (B) composition all has unique fragrance, though sometimes in cheese flavor spice etc. is in harmonious proportion spice trace use because undesirable fragrance is arranged itself, so be restricted as the use of the spice of Dentrifice composition.The inventor finds, the specific spice of so above-mentioned (B) composition and isopropyl methyl phenol also with being mixed in the Dentrifice composition, all of a sudden, can fully be suppressed the abnormal flavour from isopropyl methyl phenol.

And then, among the present invention,, can improve anelasticity and no viscous sense in the oral cavity of preparation more through (D) composition/(C) composition is 0.6～1.8 by quality ratio.

In addition, among the present invention,, can reduce distinctive abnormal flavour more, further improve usability through in the Dentrifice composition that has mixed above-mentioned (A)～(E) composition, further mixing (F) anisaldehyde.

Therefore, the present invention provides following Dentrifice composition.

(1) a kind of Dentrifice composition is characterized in that, contains:

(A) isopropyl methyl phenol,

(B) be selected from least a fragrance component in 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone,

(C) Sorbitol,

(D) glycerol and

(E) mean molecule quantity is 280～9,300 Polyethylene Glycol.

(2) like the Dentrifice composition of (1) record, (D)/(C) mass ratio of composition is 0.6～1.8.

(3) like the Dentrifice composition of (1) or (2) record, contain (A) composition 0.01～0.2 quality %, (B) composition 0.0001～0.1 quality %, (C) composition 5～30 quality %, (D) composition 5～30 quality %, and (E) composition 0.1～5 quality %.

(4) like the Dentrifice composition of (1), (2) or (3) record, also contain (F) anisaldehyde.

(5) like the Dentrifice composition of (4) record, contain (F) composition 0.0001～0.1 quality %.

(6) a kind of toothpaste, in (1)～(5) in the Dentrifice composition of any record further mixed-abrasive 0～50 quality %, propylene glycol 0～10 quality %, binding agent 0.1～5 quality %, 0.1～10 quality % is formulated for surfactant.

[invention effect]

Dentrifice composition of the present invention, preparation is high in intraoral local anelasticity, and the oral biological film sterilizing power is excellent, and does not almost have abnormal flavour, viscous sense also little, and usability is also excellent.

The specific embodiment

Below, the present invention is detailed.Dentrifice composition of the present invention; It is characterized in that; Contain (A) isopropyl methyl phenol, (B) is selected from the fragrance component more than a kind or 2 kinds, (C) Sorbitol, (D) glycerol in 3-capryl alcohol, 3-octyl acetate, the fenchone, and (E) mean molecule quantity is 280～9,300 Polyethylene Glycol.

(A) isopropyl methyl phenol that uses among the present invention is 4-isopropyl-3-methylphenol, can use Osaka to change into the commercially available article that are called as isopropyl methyl phenol that (strain) produces.

(A) combined amount of isopropyl methyl phenol is 0.01～0.2% all (quality %, down together) of compositions, and especially suitable is 0.02～0.1%; Less than 0.01% can not be brought into play sufficient bactericidal effect sometimes, surpasses 0.2% words; Sometimes produce abnormal flavour, taste deterioration.

(B) composition is to covering from the effective fragrance component of the abnormal flavour of isopropyl methyl phenol, is the fragrance component more than a kind or 2 kinds that is selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone.

During above-mentioned fragrance component, the appropriate of 3-capryl alcohol and 3-octyl acetate and/or fenchone is suitable more than 2 kinds in combination.

Even if in the capryl alcohol, the 1-capryl alcohol of spice as Dentrifice composition commonly used not have to cover the effect from the abnormal flavour of isopropyl methyl phenol, does not suit as fragrance component of the present invention.

Above-mentioned (B) composition can use commercially available article, and for example the 3-capryl alcohol can use the product of the wild spice of salt (strain), 3-octyl acetate and 3-octanone can use respectively (strain) aboveground spice make product, fenchone can use the product of fragrant Rong Xingye (strain) etc.

(B) total combined amount of composition is not special limits, with respect to total composition, and preferred 0.0001～0.1%, preferred especially 0.0005～0.05%, especially preferred 0.001～0.02%.Combined amount less than 0.0001% can not be covered the abnormal flavour from isopropyl methyl phenol sometimes, and the usability variation surpasses 0.1%, and the fragrance of fragrance component itself is strong excessively, produces abnormal flavour sometimes.

(C) Sorbitol also is simultaneously to improve preparation at a main cause of intraoral anelasticity and the composition that suppresses the one of the main reasons of abnormal flavour as wetting agent.Sorbitol, so long as can be used in getting final product of common Dentrifice composition, not special the qualification specifically can be used east and changed into the D-D-sorbitol solution commercially available article such as (70% D-sorbitol solutions) that industry (strain) is produced.

The combined amount preferred composition of Sorbitol all 5～30%, embody the viewpoint of property from improving preparation at intraoral anelasticity, fragrance, more preferably 10～25%, further preferred 12～25%.Combined amount is less than 5%, and preparation is poor in intraoral anelasticity sometimes, and abnormal flavour can not be suppressed satisfactorily, and fragrance is poor, surpasses 30%, and viscous sense is sometimes increased, and usability is poor.

(D) glycerol also is simultaneously to improve preparation at a main cause of intraoral anelasticity and the composition that suppresses the one of the main reasons of viscosity as wetting agent.Glycerol is so long as can be used in getting final product of common Dentrifice composition, not special the qualification, particularly, the glycerol commercially available article such as (85% glycerol) that can use ライオ Application ケミカ Le (strain) to produce.

The combined amount preferred composition of glycerol all 5～30%, from improving the viewpoint of preparation in intraoral anelasticity, more preferably 10～25%, further preferred 12～25%.Combined amount is less than 5%, and preparation is poor in intraoral anelasticity sometimes, can not suppress the viscous sense, and usability is poor, surpasses 30%, and the viscous sense is increased, and usability is poor, produces abnormal flavour sometimes.

Among the present invention, from preparation in intraoral anelasticity, and the little viewpoint of viscous sense, (D) glycerol and (C) mass ratio of Sorbitol ((D)/(C)) preferred 0.5～2.0, preferred especially 0.6～1.8.

(E) composition is that mean molecule quantity is 280～9,300 Polyethylene Glycol, is the composition that improves the one of the main reasons of anelasticity in the oral cavity and biological film sterilizing effect.

The mean molecule quantity of Polyethylene Glycol is 280～9,300, and is preferred 380～3,800, is important from the viewpoint that can obtain from the high biological film sterilizing effect of isopropyl methyl phenol.During mean molecule quantity not sufficient 280, taste is poor sometimes, produces abnormal flavour, surpasses 9,300, and the soak into effect inner to biomembrane reduces, and bactericidal effect is poor sometimes, and the viscous sense is high, and usability is poor.

In addition; Above-mentioned mean molecule quantity is the value of mean molecule quantity of the polyethylene glycol of 2006 the 2nd editions records of accurate medicine material specification (medicine part outer article raw material specification); Promptly; Make its in pyridine with phthalic anhydride, change phthalic acid ester into, the mean molecule quantity by recording (down with) with the NaOH titration.

Particularly, can illustration Liquid Macrogol (mean molecule quantity 280～320), PEG400 (mean molecule quantity 380～420), Macrogol 600 (mean molecule quantity 570～630), cetomacrogol 1000 (mean molecule quantity 950～1,050), Macrogol 1540 (mean molecule quantity 1; 290～1; 650), Macrogol 2000 (mean molecule quantity 1,850～2,150), Macrogol 4000 (mean molecule quantity 2; 600～3; 800), polyethylene glycol 6000 (mean molecule quantity 7,300～9,300) etc.Different according to commodity, sometimes as for example Polyethylene Glycol #200 etc. between Polyethylene Glycol and numerical value labelling #.

(E) Polyethylene Glycol can use commercially available article, can use the first industrial pharmacy (strain), day oil (strain), Sanyo to change into the product of sales such as (strains).

The combined amount of above-mentioned Polyethylene Glycol, from isopropyl methyl phenol in the inner bactericidal effect this point of biomembrane, preferred composition all 0.1～5%, preferred especially 0.2～3%.Combined amount less than 0.1%, isopropyl methyl phenol descends to the inner impregnability of biomembrane sometimes, and the bactericidal effect of biomembrane inside is poor, surpasses 5%, and viscous sense is sometimes increased, and usability is poor.

And then, among the present invention, preferably mixing anisaldehyde as (F) composition, through except that the fragrance component of (B) composition, also adding anisaldehyde, can improve more coverage effect from the abnormal flavour of isopropyl methyl phenol, fragrance is better.

Anisaldehyde can use the commercially available article such as product of ocean spice (strain).Its combined amount, with respect to the compositions full dose, preferred 0.0001～0.1%, preferred especially 0.001～0.02%.Combined amount less than 0.0001% can not fully improve the coverage effect from the abnormal flavour of isopropyl methyl phenol sometimes, surpasses 0.1%, and the same with (B) composition, the fragrance of anisaldehyde itself is strong excessively sometimes, produces abnormal flavour.

When mixing (F) anisaldehyde, from improving coverage effect this point more from the abnormal flavour of isopropyl methyl phenol, (B) composition and (F) the total combined amount preferred 0.0002～0.15%, preferred especially 0.002～0.03% of composition.Add up to combined amount less than 0.0002%, can not fully improve the coverage effect of abnormal flavour sometimes, surpass 0.15%, the fragrance of (B) and (F) composition itself is strong excessively sometimes, the generation abnormal flavour.

In addition, (B) composition and (F) the preferred especially 3-capryl alcohol of combination of composition and the combination of anisaldehyde thus, for the abnormal flavour from isopropyl methyl phenol, can be brought into play especially excellent coverage effect.

Dentrifice composition of the present invention can be mixed with dentifrice, the especially toothpaste of toothpaste, liquid dentifrice, aqueous dentifrice, moistening dentifrice etc.At this moment, according to dosage form, in the scope of not damaging effect of the present invention, except that above-mentioned neccessary composition, can also mix other known additives as any composition.For example can mixed-abrasive, thickening agent, binding agent, surfactant, further mixing sweetener, antiseptic, effective ingredient, spice, coloring agent etc. mix manufacturing with these compositions with water as required.

Can give an example silicon based abrasive, calcium monohydrogenphosphate 2 hydrates, the calcium monohydrogenphosphate of silica gel, aluminosilicate, zircoaluminate etc. of grinding agent do not have series of calcium phosphate grinding agent, aluminium hydroxide, aluminium oxide, titanium dioxide, crystallinity silicic acid zirconium, polymethyl methacrylate, insoluble calcium metaphosphate, precipitated calcium carbonate, ground calcium carbonate, magnesium carbonate, magnesium phosphate, zeolite, Zirconium orthosilicate., hydroxyapatite, fluoro apatite, calcium deficiency apatite, synthetic resin based abrasive of hydrate, calcium phosphate, tetracalcium phosphate, OCP, calcium pyrophosphate etc. etc., can use more than a kind or 2 kinds.Combined amount is generally 0～50% with respect to total composition, and particularly 5～40%.

As thickening agent, except (C)～(E) composition, can also mix other known thickening agents, for example in sugar alcohol, the polyhydric alcohol such as propylene glycol, ethylene glycol, 1,3 butylene glycol, reduction starch saccharification thing more than a kind or 2 kinds.Can not mix above-mentioned thickening agent, combined amount be compositions all 0～10%, during mixing, be compositions all 2～10% and (C), (D) and (E) the total combined amount of composition preferably in 10～60% scope.

Binding agent can give an example cellulose-based binding agent, xanthan gum, carrageenan, guar gum, sodium alginate, Poise C-80M, montorillonite clay, gelatin, sodium polyacrylate of sodium carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxymethyl ethyl cellulose, methylcellulose etc. etc., can mix in them more than a kind or 2 kinds.Combined amount is generally 0.1～5% with respect to total composition.

As surfactant, can mix the anionic surfactant that is generally used in the Dentrifice composition, non-ionic surface active agent, amphoteric surfactant etc.

Can the give an example N-acyl glutamate, N-methyl-N acyl methyltaurin sodium, N-methyl-N-acyl group Sodium L-alaninate, alpha-olefin sodium sulfonate etc. of acyl sarcosinates, dodecylbenzene sodium sulfonate, hydrogenated coconut glycerine monofatty ester sulfate mono sodium, lauryl sulfoethanoic acid. sodium, N-palmityl sodium glutamate etc. of Wan base Liu Suan salt, sodium N-lauroyl sarcosinate, tetradecanoyl sodium sarcosinate etc. of sodium lauryl sulfate, sodium tetradecyl sulfate etc. of anionic surfactant; Wherein, Alkyl sulfate, especially sodium lauryl sulfate are suitable.

As nonionic surfactant, use for example polyoxyethylene hardened castor oil, sucrose fatty acid ester, alkanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl polyglucoside, lauric acid ten polyglycerin ester etc.Wherein, from the foaming this point, suitable is polyoxyethylene alkyl ether, alkyl polyglucoside etc.

Amphoteric surfactant can use lauryl dimethyl aminoacetic acid betanin, N-fatty acid distribution of coconut oil acyl group-N-carboxyl methyl-N-hydroxyethyl imidazoles betanin, fatty acid distribution of coconut oil amido propyl dimethylamino acetic acid betanin, fatty acid distribution of coconut oil amido propyl betaine etc., but be not limited to above-mentioned these.

The combined amount of surfactant normally 0.1～10%.

Sweeting agent can give an example saccharin sodium, aspartame, stevioside, Flos Chrysanthemi extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine etc., antiseptic can give an example p-Hydroxybenzoates such as butyl p-hydroxybenzoate, ethylparaben, sodium benzoate etc.

As various effective ingredient; Except isopropyl methyl phenol; Can also mix other effective ingredient, for example copper compounds such as chelating property phosphate cpd, copper gluconate, aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivants thereof such as water-soluble phosphorus acid compounds such as the potassium salt of enzymes such as fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannic fluoride, glucanase, change dextranase, phosphoric acid, sodium salt, tranexamic acid, EACA, allantoin chloro hydroxy Al, hinokitol, sodium N-lauroyl sarcosinate, ascorbic acid, acetic acid dl-tocopherol, beta-cholestanol, α-bisabolol, chlorhexidine salt, azulene, enoxolone, glycyrrhizic acid, sodium copper chlorophyllin, chlorophyll, glycerophosphate, sodium tripolyphosphate, zeolite, methoxy-ethylene, copolymer-maleic anhydride, polyvinyl pyrrolidone, epidihydrocholesterol, cetylpyridinium chloride, benzethonium chloride, beta-cholestanol, neko, zinc citrate, Radix Angelicae Sinensis pilular extract, Cortex Phellodendri extractum, Flos Matricariae chamomillae, Flos Caryophylli, Herba Rosmarini Officinalis, the extract etc. of Radix Scutellariae, Flos Carthami etc.These mixing active ingredients amounts in the scope that does not hinder effect of the present invention, can be used effective dose.

Except (B) composition and (F) the composition; As other spice; For example can use natural perfume materials such as Eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, basil oil, Cardamom oil, Fructus Coriandri oil, Fructus Piperis peppermint oil, Oleum Menthae Rotundifoliae, Herba Menthae (Ha Star カ) oil, orange oil, Fructus Citri Limoniae oil, citrus seed oil, lime oil, oil of grapefruit, grape-fruit seed oil, platinum Fructus Citri grandis oil, Oleum lavandula angustifolia, oil of rosemary, bay oil, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, Celery oil, bay tree leaf oil, Herba Origani oil, pinke needle oil, orange blossom oil, lemongrass oil, attar of roses, Jasmin oil, patchouli oil, flag flower extractum, rose absolute, orange flower absolute, Rhizoma et radix valerianae absolute oil, Fructus Mangifera Indicae absolute oil, Herba Pogostemonis absolute oil, gingerin, Fructus Piperis resinon, green pepper (Capsicum) resinon, Fructus Capsici extract; And the spice of these spice processed being crossed (heat up in a steamer portion before going, go then heat up in a steamer portion, fractional distillation, liquid-liquid extraction, purification, powder perfumeization); And limonene, sobrerone, butanols, isoamyl alcohol, n-hexylene alcohol, cis-3-hexenol, cis-6-nonenol, linalool, alpha-terpineol, menthol, benzyl alcohol, phenethanol, anethole, thymol, estragole (Methyl chavicol), eugenol, carvone, menthone, pulegone, 1; The γ of 8-eucalyptol, ionone, watermelon ketone, n-hexyl aldehyde, trans-the 2-hexenoic aldehyde, citral, cinnamic aldehyde, benzaldehyde, ethyl acetate, ethyl n-butyrate., isoamyl acetate, Exceed 600, ethyl 2-methylbutyrate, allyl bexanoate, cyclohexane extraction allyl propionate, linalyl acetate, menthyl acetate, menthyl lactate, carvacryl acetate, phenoxyethyl isobutanoate, (-)-methyl cis-2-pent-2'-enyl-3-oxocyclopentylacetate, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl 2-aminobenzoate, phenylethyl glycidic ester, ethyl lactate, vanilione, maltol, carbon number 4～12 and δ lactone, ambrettolide, dimethylsulphide, trimethylpyrazine, Beta-methyl ethyl thio, furanone, ethylcyclopentenolone, 3-methyl cyclopentane-1; 2-diketone (Cyclotene), 2-Methyl Butyric Acid, propanoic acid, p-met hoxycinnamic aldehyde, 3-1-menthoxypropane-1; Single article spice such as 2-glycol, menthone glycerol acetal, spilanthol, monomethyl succinate, linalool oxide, vanillyl butyl ether, isopulegol; And then; Can also make up the mediation spice that uses strawberry essence, apple essence, melon essence, flavoring banana essence, flavoring peach essence, rasp berry essence, flavoring pineapple essence, grape essence, tropical fruit (tree) essence, Fructus Mangifera Indicae essence, prunus mume (sieb.) sieb.et zucc. essence, orange essence, Fructus Citri Limoniae essence, grapefruit essence, tea essence, butter essence, milk flavour etc., and the known perfume base that in Dentrifice composition, uses such as the perfume solvent of ethanol, propylene glycol, glyceryl triacetate, fatty acid glyceride etc.The combined amount of these perfume bases is not special to be limited, and preferably in compositions, uses 0.000001～1%.In addition, use spice, preferably in compositions, use 0.1～2.0% as the tax of using above-mentioned perfume base is fragrant.

Coloring agent can give an example blue No. 1, yellow No. 4 (FD&C, Yellow No.5 (19140)), green No. 3 etc.In addition, the combined amount of these compositions in the scope of not damaging effect of the present invention, can be used common amount.

Take in the not special restriction of material of the container of Dentrifice composition of the present invention, can use the normally used container of Dentrifice composition.Particularly, can use the plastic containers etc. of polyethylene, polypropylene, PETG, nylon etc.

[embodiment]

Below, enumerate embodiment and comparative example the present invention is detailed, but the present invention is not limited by following examples.In addition, in the following example, the short of special record of % is meant quality %.

(embodiment, comparative example)

According to the Dentrifice composition of forming shown in following manufacturing approach preparation table 3～5 (toothpaste).

(manufacturing approach)

(1) under the room temperature in pure water mixed dissolution water soluble ingredient (except binding agent, the propylene glycol) preparing A phase.

(2) preparation makes binding agent be dispersed in the B phase in the propylene glycol at normal temperatures.

(3) stir in B add to mutually A mutually in, mix preparation C phase.

(4) use 1.5L kneader (tor work is produced) with water soluble ingredients such as spice, grinding agent composition in addition be mixed at normal temperatures C mutually in, reduce pressure (4kPa) carries out deaeration, obtains Dentrifice composition 1.2kg.

In addition; Isopropyl methyl phenol (Osaka changes into (strain) and produces), Sorbitol (east with change into that industry (strain) is produced, D-D-sorbitol solution (70% aqueous solution)), glycerol (ライオ Application ケミカ Le (strain) is produced, 85% glycerol), Macrogol 4000 (the first industrial pharmacy (strain) is produced, mean molecule quantity 3,500) are used in the preparation of Dentrifice composition.

Again, be the composition of aqueous solution for form, comprise the combined amount of all representing to be converted into pure branch in the table.

As (B) fragrance component, the 3-capryl alcohol uses the wild spice of salt (strain) production, 3-octyl acetate and 3-octanone to use the product that (strain) aboveground spice making is produced, fenchone uses fragrant Rong Xingye (strain) production, anisaldehyde uses ocean spice (strain) production, 1-capryl alcohol to use high sand perfume industry (strain) to produce.

In addition, about spice, the flavor compositions A～I shown in the preparation table 1, and mix.Do not contain 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone, anisaldehyde in the flavor compositions shown in the table 1 again.

[table 1]

[table 2-1]

< essence 1 is formed >
		Orange oil	1 mass parts
Lime oil	1
		Oil of grapefruit	1
Platinum Fructus Citri grandis oil	1
		Grape-fruit seed oil	1
Citral	1
		Ethanol	1
Add up to	7 mass parts

[table 2-2]

< essence 2 is formed >
		Eucalyptus oil	1 mass parts
Oleum Cinnamomi	1
		Oleum Caryophylli	1
Sage oil	1
		Cardamom oil	1
Fructus Coriandri oil	1
		Bay oil	1
Flos Matricariae chamomillae oil	1
		Caraway oil	1
Ethanol	1
		Add up to	10 mass parts

[table 2-3]

< essence 3 is formed >
		Wintergreen oil	1 mass parts
Olibanum oil	1
		Orange blossom oil	1
Indian oil of verbena	1
		Oleum Rosae Rugosae	1
Rose absolute	1
		The Fructus Mangifera Indicae absolute oil	1
Flag flower extractum	1
		Orange flower absolute	1
Ethanol	1
		Add up to	10 mass parts

[table 2-4]

< essence 4 is formed >
		Menthyl lactate	1 mass parts
3-1-menthoxypropane-1, the 2-glycol	1
		The menthone glycerin ether	1
Spilanthol	1
		Monomethyl succinate	1
The linalool oxide	1
		The vanillyl butyl ether	1
Isopulegol	1
		Fructus Capsici extract	1
Gingerin	1
		The Fructus Piperis resinon	1
The green pepper resinon	1
		Ethanol	1
Add up to	13 mass parts

[table 2-5]

< essence 5 is formed >
		Furanone	1 mass parts
Ethylcyclopentenolone	1
		3-methyl cyclopentane-1, the 2-diketone	1
2-Methyl Butyric Acid	1
		Propanoic acid	1
P-met hoxycinnamic aldehyde	1
		Ethanol	1
Add up to	7 mass parts

[table 2-6]

< essence 6 is formed >
		Cis-3-hexenol	1 mass parts
Trans-the 2-hexenoic aldehyde	1
		Ethyl n-butyrate.	1
γ-hendecane lactone	1
		δ-hendecane lactone	1
γ-decalactone	1
		δ-Gui Neizhi	1
Nonyl lactone	1
		δ-nonalactone	1
γ-Ji Neizhi	1
		δ-caprolactone	1
Isoamyl acetate	1
		Benzaldehyde	1
Exceed 600	1
		The 2-Methyl Butyric Acid ethyl ester	1
Benzyl alcohol	1
		α-terpene alcohol	1
Linalyl acetate	1
		The glycidic acid phenethyl ester	1
Phenethanol	1
		Allyl hexanoate	1
Methyl cinnamate	1
		Ionone	1
The Beta-methyl ethyl thio	1
		Cis-6-nonenyl aldehyde	1
Watermelon ketone	1
		(-)-methyl cis-2-pent-2'-enyl-3-oxocyclopentylacetate	1
Ethanol	1
		Add up to	28 mass parts

The Dentrifice composition 50g of preparation is filled in the laminated tube (the white LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30 of LDPE55/PET12/LDPE20/, thick 257 μ m (Dai Nippon Printing's (strain) production)) of the diameter 26mm that innermost layer is made up of straight chain shape low density polyethylene (LDPE).

Abbreviation and title in the layer structure of the laminated tube that uses are as follows, the thickness of each layer of numeral behind the abbreviation (μ m).

LDPE: low density polyethylene (LDPE)

White LDPE: white low density polyethylene

LLDPE: straight chain shape low density polyethylene (LDPE)

AL: aluminum

PET: PETG

EMAA: ethylene methacrylic acid copolymer resin

For the Dentrifice composition that obtains, estimate what, the having or not of abnormal flavour of the viscous sense of preparation when intraoral anelasticity, bactericidal effect, the use according to following method.The result is recorded in table 3～5 in the lump.

(1) evaluation methodology of the retention effect of preparation (anelasticity in the oral cavity)

In the tool plug test tube that the Dentrifice composition that about 1.0g prepares is housed, add 20mL water, vigorous stirring is after 10 seconds up and down, and the dissolving of measuring Dentrifice composition this moment is residual, with its hold-up as preparation, according to the intraoral anelasticity of following standard evaluation.Measured value with the initial stage quality before stirring is 100%, after the residual component of the Dentrifice composition after stirring is filtered, calculates the percent of the measured value of the initial stage quality of the quality of residual component before with respect to above-mentioned stirring, with it as retention rate.

◎: retention rate is more than 60%

Zero: retention rate is more than 30%, less than 60%

△: retention rate is more than 10%, less than 30%

*: retention rate less than 10%

(2) model biological film sterilizing Evaluation on effect method

Handle hydroxyapatite (HA) plate of diameter 7mm with the non-stimulated saliva of the people behind the membrane filtration of 0.45 μ m; Handled 4 hours; In having added the pancreas peptone soybean broth culture medium of chlorhematin and menadione; 5 strain mixed stockers of continuous culture 2 all Streptococcus mutans (Streptococcus mutans), actinomyces naeslundii (Actinomyces naeslundii), veillonella parvula (Veillonella parvula), Fusobacterium nucleatum (Fusobacterium nucleatum) and porphyromonas gingivalis (Porphyromonas gingivalis) form the model biomembrane on the HA plate.Cultivate 2 Zhou Houqi, 1 time on the 1st, in the dentifrice formulation shown in the following table 3～5, add 2 times of quality population saliva (50mmol/L KCl+1mmol/LKH ₂PO ₄+ 1mmol/L CaCl ₂+ 0.1mmol/L MgCl ₂(pH7.0)), the centrifuged supernatant after the dispersion impregnated in the model biomembrane wherein as test medicine liquid, and impregnation process 3 minutes was cultivated 3 again.Cultivate when finishing, take out the model biomembrane, after the dispersion, on agar plate, cultivate, obtain the viable count of each bacterial classification in the model biomembrane thus.Viable count is because of condition of culture more or less changes, and makes population saliva replace test medicine to do the time spent, is judged as biological film sterilizing power height when about 8.5log cfu (CFU/HA plate), not enough 6.0log cfu/HA plate.

Model biological film sterilizing effect assessment benchmark

◎: not enough 5.0log cfu/HA plate

Zero: more than the 5.0log cfu/HA plate～not enough 6.0log cfu/HA plate

△: more than the 6.0log cfu/HA plate～not enough 7.0log cfu/HA plate

*: more than the 7.0log cfu/HA plate

(3) use in what evaluation methodology of viscous sense

Adopt 10 people's jury of experts to estimate through sensory test.The about 1g of Dentrifice composition placed on the commercially available article toothbrush brushed teeth 3 minutes, for what of viscous sense in using, through estimating according to following 4 grades with the comparison of reference substance (comparative example 2).According to following standard, with 10 average marks with ◎, zero, △, * expression.

Use how many (reference substances: comparative example 2) of the intraoral viscous sense in back

4: compare the viscous sense with reference substance considerably less

3: compare the viscous sense with reference substance quite few

2: compare the viscous sense with reference substance less slightly

1: compare equal with reference substance or the viscous sense more

The usability evaluation criterion

◎: more than 3.0 minutes～below 4.0 minutes

More than zero: 2.0 minute～less than 3.0 minutes

△: more than 1.5 minutes～less than 2.0 minutes

*: less than 1.5 minutes

(4) evaluation methodology of free from extraneous odour is arranged

Adopt 10 people's jury of experts to estimate through the sense test.The about 1g of Dentrifice composition placed on the commercially available article toothbrush brushed teeth 3 minutes,, estimate according to following scoring for whether feeling abnormal flavour in using.Obtain the meansigma methods of 10 people's evaluation result, according to following standard, the Dentrifice composition that can guarantee to be evaluated as ◎ and zero evaluation is judged as the Dentrifice composition that does not have abnormal flavour.

Having or not of abnormal flavour

4 minutes: do not have abnormal flavour fully

3 minutes: almost do not have abnormal flavour

2 minutes: abnormal flavour slightly

1 minute: abnormal flavour is arranged

The evaluation criterion that abnormal flavour has or not

◎: more than 3.7 minutes～below 4.0 minutes

◎～more than zero: 3.3 minute～less than 3.7 minutes

More than zero: 3.0 minute～less than 3.3 minutes

△: more than 2.0 minutes～less than 3.0 minutes

*: less than 2.0 minutes

[table 3-1]

[table 3-2]

[table 3-3]

[table 3-4]

In the foregoing description 1～40, change flavor compositions A among flavor compositions B～I each and can obtain same result.

[table 4]

[table 5-1]

[table 5-2]

[table 5-3]

[table 5-4]

[table 5-5]

Claims

1. a Dentrifice composition is characterized in that, contains:

(A) isopropyl methyl phenol,

(C) Sorbitol,

(D) glycerol and

(E) mean molecule quantity is that 280～9,300 Polyethylene Glycol forms.

2. like the Dentrifice composition of claim 1 record, (D)/(C) mass ratio of composition is 0.6～1.8.

3. like the Dentrifice composition of claim 1 or 2 records, contain (A) composition 0.01～0.2 quality %, (B) composition 0.0001～0.1 quality %, (C) composition 5～30 quality %, (D) composition 5～30 quality %, and (E) composition 0.1～5 quality %.

4. like the Dentrifice composition of claim 1,2 or 3 records, also contain (F) anisaldehyde.

5. like the Dentrifice composition of claim 4 record, contain (F) composition 0.0001～0.1 quality %.

6. toothpaste, in claim 1～5 in the Dentrifice composition of any record further mixed-abrasive 0～50 quality %, propylene glycol 0～10 quality %, binding agent 0.1～5 quality %, 0.1～10 quality % is formulated for surfactant.