JPS63192712A - Toothpaste - Google Patents

Abstract

PURPOSE:To obtain a toothpaste having improved stability of vitamin E with time and filled in a container having an inner surface made of a synthetic resin, by using vitamin E and a specific (bi)carbonate as essential components of the toothpaste. CONSTITUTION:A toothpaste containing vitamin E is compounded with a salt selected from sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate and magnesium bicarbonate and filled in a container having synthetic resin inner surface. The content of vitamin E in the toothpaste is preferably 0.001-5wt.% and that of the salt is preferably 0.1-50wt.%, especially 0.5-25wt.%.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention is a toothpaste containing vitamin E, which is filled in a container having an inner surface made of synthetic resin, and which has improved stability over time of vitamin E. Regarding toothpaste.

[Conventional technology]

Vitamin E (copherol) (practically used in the form of salts such as tocopherol acetate) has a blood circulation promoting effect, so adding it to your toothpaste will strengthen your gums and prevent alveolar pyorrhea. known to be effective.

On the other hand, toothpaste is often filled into containers having an inner surface made of synthetic resin. However, if such containers are filled with toothpaste containing vitamin E, there is a drawback that the activity of vitamin E decreases over time.

[Problem that the invention seeks to solve]

Therefore, an object of the present invention is to provide a toothpaste whose vitamin E activity does not decrease over time even when the toothpaste is filled into a container having an inner surface made of synthetic resin.

[Means for solving problems]

The object of the invention is achieved by including specific salt compounds in the toothpaste. That is, the present invention provides a toothpaste containing vitamin E, which is packed in a container having an inner surface made of synthetic resin, and which contains the group consisting of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, and magnesium bicarbonate. A toothpaste characterized by containing at least one kind of salt selected from.

The content of vitamin E is 0.01 to 5% (weight%, the same applies hereinafter), and the content of salt is 0.1 to 50%, preferably 0.5
~25% is suitable.

As used herein, the term "vitamin E" refers to not only tocopherol itself, but also its salts, such as tocopherol acetate.

As the toothpaste base material of the present invention, those commonly used in conventional toothpastes can be used.

Specific examples of these dentifrice base materials and their preferred blending amounts are shown below.

Moisturizers: Glycerin, sorbitol, 10-40% propylene glycol, polyethylene glycol, xylitol, dipropylene glycol, sodium lactate, maltitol, etc. Abrasives: Calcium hydrogen phosphate for toothpaste, 10-50% anhydrous calcium phosphate, calcium pyrophosphate, carbonate Calcium, crystalline cellulose, aluminum hydroxide, insoluble sodium metaphosphate, hydroxyapatite, etc. Foaming agents Sodium lauryl sulfate, 0.1-5% sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosine, sucrose fatty acid ester , polyoxyethylene sorbitan, polyoxyethylene nonylphenyl ether, alkylamide, amphoteric surfactant, etc. Binder carboxymethyl cellulose, 0.1-5% hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, methyl cellulose, etc. Sweeteners Sabcalin sodium → mu, stevi 0.1-3% ocide, glycyrrhizin, chalcone, dihydrochalcone, etc. Preservatives Roseoxybenzoic acid ester 0.01-0.1
%Sil fragrances Essential oils such as peppermint and spearmint,! The toothpaste of the present invention also contains 1% flavoring materials such as menthol, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine, sorbic acid, alxidine, hinokitiol, cetylpyridinium chloride, alkylglycine, sodium chloride, It may contain active ingredients such as allanthone, ε-aminocaproic acid, tranexamic acid, azulene, sodium fluoride, fluorides such as sodium monofluorophosphate, aluminum lactate, edetate, color I BHT, and isopropyl methylphenol. can.

In the present invention, a "container with an inner surface made of synthetic resin" refers to a container whose portion that comes into contact with toothpaste is made of a synthetic resin such as polyolefin such as polyethylene, polypropylene, polyethers, Surlyn, nylon, or vinyl chloride. means a tube or other container containing

Specific examples of such containers include polyethylene, paper,
Laminated tubes made of aluminum etc. whose innermost layer is made of polyethylene, polyethers, Surlyn, nylon, etc.; Volitinip, polyethylene, polypropylene made of at least one of polyethylene, polypropylene, nylon, vinyl chloride, etc. Examples include poly containers made of at least one of , nylon, vinyl chloride, and the like.

Example 1 A toothpaste with the following formulation was prepared.

Tocopherol acetate 0.1g Sodium hydrogen carbonate xg Calcium hydrogen phosphate for toothpaste 45.0g Glycerin
20.0 g Sodium lauryl sulfate
1.5g methylparaben
0.1g saccharin sodium
0.1g fragrance
Add 0.9g of water to make the total amount 100g. This was placed in a laminated tinib (innermost polyethylene layer) and stored at 40°C for 2 months. The amount of sodium bicarbonate added was changed as follows, and the samples were stored at 40°C for 2 months. The residual rate of tocopherol acetate after storage was as follows.

Sodium hydrogen carbonate Tocopherol acetate added
Amount Remaining rate (%)Q
71.5 0, 1 81.1 0, 5 82.0 1, 0 81.6 2, 0 85.8 5, 0 9 t, 5 10, 0 94.2 15, 0 99.5 20, 0 98 .9 25, 0 99.7 0 Method for measuring residual amount of tocopherol acetate After extracting the sample with methanol, measure by liquid chromatography, and calculate the ratio when the initial value is 100.

Examples 2 to 5 When the following salt was used in place of sodium hydrogen carbonate in Example 1 and the amount added was 5.0 g, the residual rate of tocopherol acetate after storage at 40°C for 2 months was as follows. there were.

Sodium carbonate 97.1 Potassium carbonate 98.5 Potassium hydrogen carbonate 98.3 Calcium hydrogen carbonate 80.4 Examples 6 to 9 In Example 1, the amount of sodium hydrogen carbonate added was 5%, and this was filled into the following resin container. After storage at 40°C for 2 months, the residual rate of tocopherol acetate was measured.

Surlyn 98.5 (75,0) nylon
99.0 (83,4) vinyl chloride
98.5 (80,0) Polypropylene 98
．． 2(70,6) () indicates the residual rate in the case without addition of sodium hydrogen carbonate.

Example 10 Sodium hydrogen phosphate 41.0 g Glycerin 20.0 g Sodium lauryl sulfate 1.5 g Sodium lauroyl sarcosine 0.1 g Sodium saccharin 0.1 g Tocopherol acetate
0.1g sodium bicarbonate
5.0g fragrance
Total amount is 100g with 1.0g water
shall be.

Example 11 Calcium pyrophosphate 35.0 g Silicic anhydride 5.0 g Crystalline cellulose 5.0 g Methyl cellulose 0.5 g Carrageenan
0.5g glycerin
20.0 g sorbitol liquid
5.0g propylene glycol
3.0g Sodium lauryl sulfate 1.5
g Alcalolamide 0.1g Sodium saccharin 0.1g Tocopherol acetate 0.2g Sodium bicarbonate 1.0g Flavor
Add 0.9g of water to make the total amount 100g.

Example 12 Sodium hydrogen phosphate 33. Og carrageenan 0.5g glycerin 15.0g sorbitol liquid
10.0 g Sodium lauryl sulfate 0.5 g Polyoxyester Solpitan 0.5 g Sodium chloride
10.0 g sodium bicarbonate
5.0 g tocopherol acetate
0.1g fragrance
Add 0.9g of water to make the total amount 100g.

Example 13 Sodium hydrogen phosphate 35.0 g Methyl cellulose 1.0 g Glycerin 15.0 g Dipropylene glycol 5. Og Sodium lauryl sulfate 1.5g Sodium lauroyl sarcosine 0.2g Sodium saccharin
0.1 g sodium bicarbonate
15.0 g tocopherol acetate 0
．． 1g fragrance
Add 0.9g of water to make the total amount 100g.

Example 14 Calcium hydrogen phosphate 40.0 g Silicic anhydride 5.0 g Sodium alginate 2.0 g Carrageenan
0.5g glycerin
10.0 g sorbitol solution
10.0 g sodium lactate
5.0g polyoxyethylene sorbitan 2
．． 0 g Sodium chloride 5.0
g Sodium carbonate 2.0 g Tocopherol acetate 0.1 g Judgment
Fee 0
．． Add 9 g of water to bring the total amount to 100 g.

Example 15 Calcium hydrogen phosphate 20.0 g Crystalline cellulose 18.0 g Hydroxyethyl cellulose 1.0 g Sorbitol solution 20.0 g Polyethylene glycol (600) 5.0 g Polyoxyethylene nonylphenyl ether 1.5 g Sodium saccharin 0. 1g sodium carbonate 5.0g tocopherol acetate 0.1g fragrance
Add 0.8 g of water to bring the total amount to 100 g.

Example 16 Calcium hydrogen phosphate 35.0 g Silicic anhydride 5.0 g Glycerin 30.0 g Sodium lactate 5.0 g Sodium lauryl sulfate 2.0 g Sodium saccharin
0.15 g potassium bicarbonate
2.0g potassium carbonate
1.0g tocopherol acetate 0
．． 1g fragrance
Add 0.9g of water to make the total amount 100g.

Example 17 Calcium pyrophosphate Silicic anhydride 5.0g Crystalline cellulose 5.0g Sodium carboxymethylcellulose 1.0g Glycerin 20.0g Sorbitol solution 5.0g Propylene glycol 5. Og sodium lauryl sulfate 1.5g potassium bicarbonate
1.0g calcium bicarbonate
5.0 g tocopherol acetate
0.1g fragrance
Add 0.9g of water to make the total amount 100g.

Example 18 Calcium carbonate 30.0 g Silicic anhydride 5.0 g Methyl cellulose 0.5 g Carrageenan
0.5g glycerin
10.0 g Sorbit solution
15.0 g Sodium lauryl sulfate
1.5g sodium chloride
15.0 g sodium bicarbonate 2
．． 0g tocopherol 0.1g
fragrance
Add 0.9g of water to make the total amount 100g.

Example 19 Aluminum hydroxide 35. Og carrageenan 1.5g glycerin 20.0g sorbitol liquid
5.0g sodium lactate
5.0 g Sodium lauryl sulfate
1.5g saccharin sodium
0.1g tocopherol
0.1g Sodium hydrogen carbonate 5.0
g fragrance
Add 1.0g of water to make the total amount 100g.

Example 20 Calcium phosphate silicic anhydride 5.0 g Glycerin 20.0 g Sorbiturate solution 10.0 g Sodium lauryl sulfate 1.0 g Sodium lauroyl sarcosinate 0.3 g Aluminum lactate
0.5g tocopherol acetate
0.1g potassium carbonate
1.0 g potassium bicarbonate 5.
0g fragrance
Add 1.0g of water to make the total amount 100g.

Example 21 Aluminum hydroxide 37.0 g Anhydrous hydroxyethyl cellulose silicate 1.0 g Glycerin 20.0 g Sodium lactate 10.0 g Sodium lauryl sulfate 1.5 g Aluminum lactate
1.0g sodium bicarbonate
1.0g tocopherol acetate
0.1g flavoring
Add 0.9g of water to make the total amount 100g.

Example 22 Silicic anhydride 25. Og carrageenan 1.5g glycerin 25.0g propylene glycol 5.0g sodium lauryl sulfate 1.5g saccharin-sodium
0.05 g glycyrrhizin
0.05 g calcium bicarbonate
2.0g sodium bicarbonate
3.0g tocopherol acetate 0
．． 2g fragrance
Add 1.0g of water to make the total amount 100g.

Example 23 Aluminum hydroxide 25.0 g Silicic anhydride 10.0 g Crystalline cellulose 5.0 g Hydroxyethylcellulose 1.0 g Glycerin
10.0 g dipropylene glycol
l 0. Og sodium lauryl sulfate
1.5g stevioside
0.1g calcium bicarbonate 15
．． 0 g tocopherol acetate 0.2
g fragrance
Add 1.0g of water to make the total amount 100g.

〔Effect of the invention〕

The Streptococcus almanac of the present invention has an excellent effect in that the activity of the vitamin E contained therein decreases over time very little.

Claims (2)

[Claims] (1) In a toothpaste containing vitamin E filled in a container with an inner surface made of synthetic resin, sodium carbonate,
A toothpaste characterized by containing at least one salt selected from the group consisting of potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate. (2) The toothpaste according to claim (1), characterized in that the content of vitamin E is 0.01 to 5% and the content of salt is 0.1 to 50%.