CN113507966B

CN113507966B - Oral composition

Info

Publication number: CN113507966B
Application number: CN202080017214.3A
Authority: CN
Inventors: 内野阳介; 松冈纯枝
Original assignee: Kao Corp
Current assignee: Kao Corp
Priority date: 2019-02-28
Filing date: 2020-01-16
Publication date: 2024-01-30
Anticipated expiration: 2040-01-16
Also published as: WO2020174914A1; CN113507966A; JP2020143041A; TW202100134A; TWI842814B; JP7281423B2

Abstract

The present invention relates to an oral composition for effectively suppressing pain enhancement caused by dentin hypersensitivity by high erythritol content. Specifically, the present invention provides an oral composition comprising the following components (A), (B), (C) and (D): 6 to 33 mass% of erythritol, (B) sodium fluoride, (C) calcium glycerophosphate, and (D) water, and the mass ratio ((A)/(D)) of the content of the component (A) to the content of the component (D) is 0.06 to 0.2.

Description

Oral composition

Technical Field

The present invention relates to an oral composition.

Background

Conventionally, oral compositions using various components such as abrasives, foaming agents, and bactericides have been developed, which are effective in preventing oral diseases such as caries, periodontal disease, and halitosis, inhibiting the formation of an oral biofilm, and removing the formed biofilm.

Among such components, for example, patent document 1 discloses that erythritol is an effective component in inhibiting or decomposing the aggregation reaction between bacteria in the oral cavity, and has an excellent effect of inhibiting the formation of a biofilm and an excellent effect of removing a biofilm formed in a gap between teeth, periodontal pockets, or the like. In the dental cleaning composition described in patent document 2, the erythritol content is set to a high level, so that the biofilm removal effect in the oral cavity is further improved.

(patent document 1) Japanese patent laid-open publication No. 2005-29484

(patent document 2) japanese patent laid-open publication No. 2012-36172

Disclosure of Invention

The present invention provides an oral composition comprising the following components (A), (B), (C) and (D):

(A) 6 to 33 mass% of erythritol,

(B) Sodium fluoride,

(C) Calcium glycerophosphate,

(D) The water is used as the water source,

the mass ratio ((A)/(D)) of the content of the component (A) to the content of the component (D) is 0.06 to 0.2.

The present inventors have found that when erythritol having excellent inhibitory effect and removal effect on biofilm formation in the oral cavity is used at a high content as in the above-mentioned patent documents, pain caused by dentin hyperesthesia is enhanced due to osmotic pressure stimulation in which erythritol is dissolved in water as a main cause.

Thus, there is a strong demand for an oral composition which contains erythritol having an excellent effect of inhibiting formation or removing formation of an oral biofilm at a high content and which can effectively prevent pain caused by dentin hypersensitivity.

Accordingly, the present inventors have made various studies and as a result, have found that by setting erythritol to a high content and setting the erythritol to a specific mass ratio with water and by using sodium fluoride and calcium glycerophosphate in combination, an oral composition can be obtained which can effectively reduce osmotic pressure irritation due to erythritol and effectively form a coating of fluoride such as calcium fluoride which effectively blocks the opening of dentinal tubules in the exposed dentin surface, thereby effectively preventing pain enhancement due to dentin hyperesthesia.

Namely, the present invention relates to an oral composition which can effectively suppress the increase in pain caused by dentin hypersensitivity by high erythritol content.

According to the oral composition of the present invention, although erythritol is contained in a high amount, since the osmotic pressure irritation mainly attributed to erythritol can be reduced and the opening of the dentinal tubule on the exposed dentin surface is effectively and effectively blocked by the fluoride coating, an excellent effect of suppressing pain caused by dentin hypersensitivity can be sufficiently exhibited. Therefore, the excellent oral biofilm formation inhibition effect and removal effect can be sufficiently enjoyed by the high erythritol content.

Drawings

Fig. 1 is an electron micrograph of the surface of dentin when the oral composition of example 3 was used.

Fig. 2 is an electron micrograph of the surface of dentin when the oral composition of comparative example 2 was used.

Detailed Description

The present invention will be described in detail below.

In the present invention, the "dentinal tubule" is also referred to as "dentinal tubule". The term "sealing the dentinal tubules" means that the dentinal tubules are physically sealed, and includes not only a state where the openings or the periphery of the openings of the dentinal tubules are covered on the surface of dentin but also a state where the openings are filled in the tubules in the vicinity of the surface of the dentinal tubules and covered (plugged).

In the present invention, the term "fluoride" mainly means an inorganic compound containing fluorine such as calcium fluoride formed from the component (B) and the component (C), and a film of fluoride is also referred to as a "fluoride film".

The oral composition of the present invention contains 6 to 33 mass% erythritol as component (A). Thus, the formation of a fluoride coating film by the component (B) and the component (C), which will be described later, is promoted, and the dentinal tubules are physically blocked with high efficiency by the coating film, whereby the effect of suppressing pain caused by dentin hypersensitivity can be exerted. Further, the effect inherent to erythritol, that is, the biofilm formation inhibition effect or the biofilm removal effect can be exerted by inhibiting the coagulation reaction between bacteria or by coagulating and decomposing bacteria.

In the oral composition of the present invention, the content of the component (a) is 6% by mass or more, preferably 8% by mass or more, more preferably 10% by mass or more, still more preferably 12% by mass or more, and still more preferably 14% by mass or more, in terms of maintaining the biofilm formation inhibitory effect and the biofilm removal effect and sufficiently exhibiting the film formation promoting effect by the component (B) and the component (C). In the oral composition of the present invention, the content of the component (a) is 33 mass% or less, preferably 30 mass% or less, more preferably 25 mass% or less, still more preferably 20 mass% or less, and still more preferably 18 mass% or less, in view of effectively avoiding excessive enhancement of pain caused by dentinal hypersensitivity due to osmotic pressure stimulation. In the oral composition of the present invention, the content of the component (a) is 6 to 33 mass%, preferably 8 to 30 mass%, more preferably 10 to 25 mass%, still more preferably 12 to 20 mass%, and still more preferably 14 to 18 mass%.

The oral composition of the present invention contains sodium fluoride as component (B). In this way, the formation inhibition effect and removal effect of the biofilm by the component (a) can be ensured, and the fluoride ion can be rapidly released in the process of exerting the formation promotion effect of the coating by the component (a) after the oral composition of the present invention is applied to the oral cavity, and the fluoride coating can be efficiently formed on the surface of dentin together with the component (C) described later. Therefore, the coating effectively seals the dentinal tubules, and thus can effectively suppress the increase of pain caused by dentin hypersensitivity due to osmotic pressure stimulation, which is mainly caused by the high content of the component (a).

In view of forming a fluoride coating film efficiently, the content of the component (B) in the oral composition of the present invention is preferably 0.1 mass% or more, more preferably 0.2 mass% or more, still more preferably 0.3 mass% or more, and still more preferably 0.5 mass% or more. In the oral composition of the present invention, the content of the component (B) is preferably 2.5% by mass or less, more preferably 2.2% by mass or less, further preferably 2% by mass or less, and further more preferably 1.8% by mass or less, from the viewpoint of securing the storage stability of the composition. In the oral composition of the present invention, the content of the component (B) is preferably 0.1% by mass or more and 2.5% by mass or less, more preferably 0.2 to 2.2% by mass, still more preferably 0.3 to 2% by mass, and still more preferably 0.5 to 1.8% by mass.

The oral composition of the present invention contains calcium glycerophosphate as component (C). The component (C) can efficiently form a fluoride in cooperation with the component (B) and form a film by utilizing the effect of promoting the formation of a film of the component (a), and can greatly contribute to the sealing of the dentinal tubules.

In the oral composition of the present invention, the content of the component (C) is preferably 0.1 mass% or more, more preferably 0.3 mass% or more, still more preferably 0.5 mass% or more, and still more preferably 1 mass% or more, in view of effectively and efficiently forming a fluoride coating together with the component (B) in the presence of the component (a). In the oral composition of the present invention, the content of the component (C) is preferably 5% by mass or less, more preferably 4.5% by mass or less, further preferably 4% by mass or less, further preferably 3.5% by mass or less, from the viewpoint of securing the storage stability of the composition. In the oral composition of the present invention, the content of the component (C) is preferably 0.1% by mass or more and 5% by mass or less, more preferably 0.3 to 4.5% by mass, still more preferably 0.5 to 4% by mass, and still more preferably 1 to 3.5% by mass.

From the viewpoint of promoting the formation of a fluoride film, the mass ratio (Ca/F) of the calcium atom equivalent of the component (C) to the fluorine atom equivalent of the component (B) is preferably 0.35 or more, more preferably 0.38 or more, and still more preferably 0.42 or more. The mass ratio (Ca/F) of the calcium atom equivalent of the component (C) to the fluorine atom equivalent of the component (B) is preferably 0.55 or less, more preferably 0.52 or less, and still more preferably 0.5 or less. The mass ratio (Ca/F) of the calcium atom equivalent of the component (C) to the fluorine atom equivalent of the component (B) is preferably 0.35 to 0.55, more preferably 0.38 to 0.52, and still more preferably 0.42 to 0.5.

In terms of effectively avoiding excessive enhancement of pain caused by dentin hypersensitivity due to osmotic pressure stimulation, the ratio of the mass ratio (Ca/F) of the calcium atom conversion amount of component (C) to the fluorine atom conversion amount of component (B) to the content of component (A) ((Ca/F)/(A), unit: mass% ^-1 ) Preferably 0.015 or more, more preferably 0.017 or more, and still more preferably 0.02 or more. In terms of maintaining the biofilm formation inhibition effect and the biofilm removal effect and sufficiently exhibiting the promotion effect of the formation of the coating film by the component (B) and the component (C), the ratio of the mass ratio (Ca/F) of the calcium atom conversion amount of the component (C) to the fluorine atom conversion amount of the component (B) to the content of the component (a) ((Ca/F)/(a) is a value of the ratio in mass% ^-1 ) Preferably 0.15 or less, more preferably 0.1 or less, and still more preferably 0.07 or less. And the ratio of the mass ratio (Ca/F) of the calcium atom-converted amount of the component (C) to the fluorine atom-converted amount of the component (B) to the content of the component (A) ((Ca/F)/(A) in mass% ^-1 ) Preferably from 0.015 to 0.15, more preferably from 0.017 to 0.1, and even more preferably from 0.020 to 0.07.

From the viewpoint of sufficiently utilizing the excellent fluoride coating film formation promoting effect of the component (a), the mass ratio ((C)/(a)) of the content of the component (C) to the content of the component (a) is preferably 0.02 or more, more preferably 0.05 or more, still more preferably 0.1 or more, and preferably 0.3 or less, more preferably 0.28 or less, still more preferably 0.24 or less, still more preferably 0.18 or less. The mass ratio ((C)/(a)) of the content of the component (C) to the content of the component (a) is preferably 0.02 to 0.3, more preferably 0.05 to 0.28, still more preferably 0.1 to 0.24, still more preferably 0.1 to 0.18.

The oral composition of the present invention contains water as the component (D). By adjusting the water content, the pain enhancement caused by dentin hypersensitivity due to osmotic pressure stimulation, which is mainly caused by the high content of the component (A), is effectively avoided. In addition, the fluoride ion released from the component (B) is present in the composition, and the component (a) is sufficiently spread in the oral cavity, so that the formation of a fluoride coating formed by the component (B) and the component (C) is promoted, and the dentinal tubules can be rapidly and efficiently blocked by the coating.

The content of the component (D) in the oral composition of the present invention is preferably 55 mass% or more, more preferably 60 mass% or more, further preferably 65 mass% or more, further preferably 68 mass% or more, and preferably 93 mass% or less, more preferably 91 mass% or less, further preferably 89 mass% or less, further more preferably 88 mass% or less, further more preferably 87 mass% or less, further more preferably 86.7 mass% or less, from the viewpoint of suppressing osmotic pressure stimulation in which the component (a) is a high content, from the viewpoint of improving the blocking effect of the dental tubule by efficiently forming a fluoride coating with the component (B) and the component (C), and from the viewpoint of effectively exerting the biofilm formation suppressing effect or removing effect by the component (a). In the oral composition of the present invention, the content of the component (D) is preferably 55 mass% or more and 93 mass% or less, more preferably 60 to 91 mass%, still more preferably 65 to 89 mass%, still more preferably 68 to 88 mass%, still more preferably 68 to 87 mass%, still more preferably 68 to 86.7 mass%.

The reason why the excellent fluoride coating film formation promoting effect of the component (a) is ensured and the osmotic pressure stimulation of the component (a) is moderately controlled to a high content is that the mass ratio ((a)/(D)) of the content of the component (a) to the content of the component (D) is 0.06 or more, preferably 0.08 or more, more preferably 0.09 or more, still more preferably 0.1 or more, and 0.3 or less, preferably 0.26 or less, still more preferably 0.24 or less, and still more preferably 0.22 or less, in view of improving the sealing effect of the dental tubule of the fluoride coating film. The mass ratio ((a)/(D)) of the content of the component (a) to the content of the component (D) is 0.06 to 0.3, preferably 0.08 to 0.26, more preferably 0.09 to 0.24, and still more preferably 0.1 to 0.22.

The oral composition of the present invention is preferably limited to containing an anionic surfactant in view of effectively and efficiently forming a fluoride coating by the component (B) and the component (C) in the presence of the component (a). The anionic surfactants include: sodium lauryl sulfate, sodium lauroyl methyl taurate, and the like. The content of the anionic surfactant in the oral composition of the present invention is preferably less than 1% by mass, more preferably less than 0.6% by mass, still more preferably less than 0.4% by mass, still more preferably less than 0.2% by mass, still more preferably less than 0.08% by mass, or the oral composition of the present invention preferably does not substantially contain the anionic surfactant.

In view of improving the sealing effect of the dentinal tubules by the fluoride coating by effectively and efficiently forming the fluoride coating by the component (B) and the component (C) in the presence of the component (a), the oral composition of the present invention preferably contains a total amount of the fluoride compound and the polyvalent metal salt other than the component (B). The fluorine compounds other than the component (B) are specifically exemplified by the following: fluorine-containing compounds such as potassium fluoride and ammonium fluoride, and sodium monofluorophosphate. The polyvalent metal salt may be, specifically, one or more salts selected from the group consisting of copper, iron, calcium, magnesium, aluminum, zinc, and tin. The total content of the fluorine compound and the polyvalent metal salt other than the component (B) in the oral composition of the present invention is preferably less than 0.02 mass%, more preferably not more than 0.015 mass%, still more preferably not more than 0.005 mass%, or the oral composition of the present invention preferably does not contain the fluorine compound and the polyvalent metal salt other than the component (B).

The oral composition of the present invention may contain no abrasive, or may contain an abrasive within the limits of the total content of the fluorine compound and the polyvalent metal salt other than the component (B). The polishing agent may be 1 or 2 or more polishing agents selected from the group consisting of abrasive silica (oil absorption: 50 to 150mL/100g, produced from the amount of boiled linseed oil absorbed in accordance with JIS K5101-13-2 (formulated in 2004)), dibasic calcium phosphate-dihydrate and anhydrate, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, magnesium acetate, dibasic magnesium phosphate, zeolite, and the like.

The oral composition of the present invention may contain, in addition to the above-mentioned components, appropriately in a range that does not hinder the effects of the present invention: cationic surfactants or amphoteric surfactants such as coconut oil amide propyl betaine, and nonionic surfactants such as polyoxyethylene hydrogenated castor oil or sucrose fatty acid ester, sorbitan fatty acid ester; polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, and the like; binding agents such as sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth, acacia, guar gum, and the like; tackifying silica; sweetener such as saccharin sodium; a perfume; a pigment; the medicinal components.

The pH of the oral composition of the present invention at 25 ℃ is preferably 5.0 or more, more preferably 6.0 or more, still more preferably 6.5 or more, still more preferably 6.7 or more, from the viewpoint of promoting formation of a fluoride coating by the component (B) and the component (C) efficiently in the presence of the component (a). The pH of the oral composition of the present invention at 25 ℃ is preferably 10.0 or less, more preferably 9.6 or less, still more preferably 9.3 or less, and still more preferably 8.8 or less, from the viewpoint of avoiding discoloration of the composition.

The pH value of the oral composition of the present invention is a value measured at 25 ℃ using a pH electrode, and when the oral composition of the present invention is a liquid dentifrice composition, the pH value means a value measured when the oral composition of the present invention is an undiluted composition, and when the oral composition of the present invention is a toothpaste composition, the pH value means a value measured after the oral composition is adjusted to a 10 mass% aqueous solution using purified water containing ion-exchanged water or distilled water.

The oral composition of the present invention can effectively and effectively prevent pain caused by dentin hypersensitivity by a fluoride coating film, and therefore can be widely used as an oral composition for dentin hypersensitivity, that is, a dentin hypersensitivity mitigant or prophylactic agent.

The method for producing the oral composition of the present invention is not particularly limited, and the above components may be appropriately mixed by a conventional method.

With respect to the above embodiments, the present invention further discloses the following oral compositions.

[1] An oral composition comprising the following components (A), (B), (C) and (D):

(A) 6 to 33 mass% of erythritol,

(B) Sodium fluoride,

(C) Calcium glycerophosphate,

(D) The water is used as the water source,

[2] The oral composition according to the above [1], wherein the content of the component (A) is preferably 8% by mass or more, more preferably 10% by mass or more, still more preferably 12% by mass or more, still more preferably 14% by mass or more, and preferably 30% by mass or less, more preferably 25% by mass or less, still more preferably 20% by mass or less, still more preferably 18% by mass or less.

[3] The oral composition according to the above [1] or [2], wherein the content of the component (B) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, still more preferably 0.3% by mass or more, still more preferably 0.5% by mass or more, and preferably 2.5% by mass or less, more preferably 2.2% by mass or less, still more preferably 2% by mass or less, and still more preferably 1.8% by mass or less.

[4] The composition for oral cavity according to any one of [1] to [3], wherein the content of the component (C) is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, further preferably 0.5% by mass or more, further preferably 1% by mass or more, and preferably 5% by mass or less, further preferably 4.5% by mass or less, further preferably 4% by mass or less, further preferably 3.5% by mass or less.

[5] The oral composition according to any one of [1] to [4], wherein the content of the component (D) is preferably 55% by mass or more, more preferably 60% by mass or more, still more preferably 65% by mass or more, still more preferably 68% by mass or more, and preferably 93% by mass or less, more preferably 91% by mass or less, still more preferably 89% by mass or less, still more preferably 88% by mass or less, still more preferably 87% by mass or less, still more preferably 86.7% by mass or less.

[6] The composition for oral cavity according to any one of the above [1] to [5], wherein the mass ratio ((A)/(D)) of the content of the component (A) to the content of the component (D) is preferably 0.08 or more, more preferably 0.09 or more, still more preferably 0.1 or more, and preferably 0.26 or less, more preferably 0.24 or less, still more preferably 0.22 or less.

[7] The oral composition according to any one of the above [1] to [6], wherein the content of the anionic surfactant is preferably less than 1% by mass, more preferably less than 0.6% by mass, still more preferably less than 0.4% by mass, still more preferably less than 0.2% by mass, still more preferably less than 0.08% by mass, or substantially no anionic surfactant.

[8] The composition for oral cavity according to any one of [1] to [7], wherein the mass ratio (Ca/F) of the calcium atom-converted amount of the component (C) to the fluorine atom-converted amount of the component (B) is preferably 0.35 or more, more preferably 0.38 or more, still more preferably 0.42 or more, and preferably 0.55 or less, more preferably 0.52 or less, still more preferably 0.5 or less.

[9] The composition for oral use according to any one of the above [1] to [8], wherein the total content of the fluorine compound and the polyvalent metal salt other than the component (B) is preferably less than 0.02% by mass, more preferably 0.015% by mass or less, still more preferably 0.005% by mass or less, or the fluorine compound and the polyvalent metal salt other than the component (B) are not contained.

[10] The composition for oral cavity according to any one of the above [1] to [9], wherein the mass ratio ((C)/(A)) of the content of the component (C) to the content of the component (A) is preferably 0.02 or more, more preferably 0.05 or more, further preferably 0.1 or more, and preferably 0.3 or less, more preferably 0.28 or less, further preferably 0.24 or less, further more preferably 0.18 or less.

[11]As described above [1]]To [10]]The oral composition according to any one of the above, wherein the ratio by mass of the calcium atom-converted amount of the component (C) to the fluorine atom-converted amount of the component (B) (Ca/F) to the content of the component (A) ((Ca/F)/(A), unit: mass% ^-1 ) Preferably 0.015 or more, more preferably 0.017 or more, further preferably 0.02 or more, and preferably 0.15 or less, more preferably 0.1 or less, further preferably 0.07 or less.

[12] The oral composition according to any one of [1] to [11], wherein the pH at 25℃is preferably 5.0 or more, more preferably 6.0 or more, still more preferably 6.5 or more, still more preferably 6.7 or more, and preferably 10.0 or less, more preferably 9.6 or less, still more preferably 9.3 or less, still more preferably 8.8 or less.

Examples (example)

The present invention will be specifically described below based on examples. Unless otherwise indicated in the table, the content of each component represents mass%.

Examples 1 to 12 and comparative examples 1 to 5

The liquid dental cleaning compositions of examples 1 to 12 and comparative examples 1 to 5 shown in table 1 were produced by mixing the respective components by a conventional method.

Then, using the obtained liquid dental cleaning composition and the following dentin sample, observation of the state of blocking the opening of the dentinal tubules and the fluoride coating film was performed by the following method, and evaluation of the hypersensitive function and measurement of the inhibition rate of tartar formation were performed.

Test 1: evaluation of opening sealing and formation of fluoride coating of dentinal tubule

Preparation of dentin sample

The surfaces of sections (thickness: about 500 μm) of the dentin of bovine teeth, which were about 1cm in size, were mirror polished with a sand paper having an abrasive grain size of 40 μm and a sand paper having an abrasive grain size of 3 μm, and then subjected to ultrasonic treatment for 10 minutes. Then, the coating layer was completely removed by performing an etching treatment with a 1% aqueous solution of citric acid for 20 seconds and further performing an ultrasonic treatment for 10 minutes, thereby exposing the opening of dentin tubules of dentin of bovine teeth.

Electron microscope observation

The obtained dentin sample was immersed in 10mL of each of the liquid dental compositions of example 3 and comparative example 2 for 5 minutes, and then the sample was washed with distilled water for 10 seconds. After washing, platinum was deposited on the surface of the sufficiently dried sample, and the opening of the dentin tubule in the surface was observed at a magnification of 2000 times by using an electron microscope (VE-7800, manufactured by KEYENCE Co., ltd., acceleration voltage of 2 kV), to confirm the state of blocking the opening of the dentin tubule and the state of formation of the fluoride coating.

The results are shown in FIGS. 1 to 2.

From the results of fig. 1 to 2, in example 3, it was confirmed that the openings of the dentin tubules on the surface of the sample were sufficiently blocked by being well covered with the fluoride coating, whereas in comparative example 2, it was confirmed that the attachments were confirmed on the surface of dentin, but only the portions covering the openings of the dentin tubules and the portions where the dentin was exposed were scattered.

Test 2: evaluation of hyperesthesia function

The evaluation of pain caused by dentin hypersensitivity was performed on the basis of the following criteria by taking a person who felt to be stink every day or a person who felt to be stink 2 to 3 times per week during the last 1 month as a functional inspector, holding each liquid dental cleaning composition for 30 seconds, rinsing the mouth, and thereafter cooling the mouth.

4: no stinging at all

3: hardly feel stinging

2: feel some Xu Citong

1: feel tingling

The average value of the evaluation results of 3 functional inspectors is shown in table 1.

Test 3: determination of inhibition of tartar formation

1) Treatment of HAp substrates with liquid dental cleaning compositions

One surface of the HAp substrate (manufactured by COSMO BIO corporation, 1cm square) was mirror polished with polishing paper of 40 μm, 12 μm, and 3 μm, and then immersed in 1N HCl for 1 minute, followed by acid decalcification treatment. The HAp plate after the treatment was washed with ion-exchanged water, dried, placed in a 24-well plate, and 1mL of each of the liquid dental cleaning compositions obtained in examples and comparative examples was added thereto, followed by shaking for 5 minutes. The shaking was performed at room temperature (25 ℃) and 500rpm using a shaker (BioShake iQ (manufactured by WAKENBTECH)). Thereafter, each liquid dental cleaning composition was sucked out, 1mL of ion-exchanged water was added thereto, and after shaking for 5 minutes, the water was sucked out to prepare a treatment substrate.

2) Stimulated saliva collection

The saliva is collected in a Falcon tube by chewing gum pellets contained in Dentobuff Strip (Oralcale Inc.) and discharging saliva accumulated in the mouth each time into the Falcon tube for a healthy male aged 20 to 30 years. Furthermore, since bacteria in saliva are different from each other, the inhibition rate of tartar formation was measured for all examples and comparative examples based on saliva of 1 healthy male.

3) Preparation of model dental calculus

Next, saliva collected in the Falcon tube in 2) was centrifuged at 3000rpm/rt/10 min. After adding sucrose 5 mass% to the separated supernatant saliva to prepare a sucralose solution, the solution was stirred using a stirring machine (Voltex, manufactured by NIPPON Genetics company) to prepare a tartar model test solution.

4) Evaluation of inhibition of tartar formation

Adding 1mL of the model tartar test solution prepared in 3) to the HAp substrate treated in 1) per hole, and then mixing the HAp substrate with CO ₂ The bags were stored together in a plastic box and incubated at 37℃for 24 hours under anaerobic conditions.

5) CV staining of tartar

The model tartar test solution in the plate was sucked off using a decompression pump, 1mL of ion exchange water was added, and the mixture was shaken for 5 minutes. Next, 750 μl of 0.1 mass% Crystal Violet (CV) solution was added to the solution by pumping water, and the solution was shaken for 15 minutes.

Further, the CV solution was sucked off by a pump, 1mL of ion exchange water was added thereto, and the mixture was shaken for 5 minutes, and the above-mentioned operation was repeated 2 times. Then, water was removed by pumping, 500. Mu.L of ethanol was added thereto, and after pipetting, the extract was diluted 10-fold with ion-exchanged water.

6) Evaluation of inhibition of tartar formation

The absorbance OD of the obtained 10-fold dilution of ion-exchanged water was measured by a microplate reader (wavelength-variable light-absorbing microplate reader Sunrise Rainbow Thermo manufactured by TECAN Corp.) _595nm 。

Further, the absorbance OD in the case of producing model tartar on the HAp plate after the acid decalcification treatment without treatment with the liquid dental scaler composition obtained as described above was used _595nm The inhibition rate (%) of tartar formation was calculated based on the following formula (initial value).

Furthermore, the larger the value of the obtained tartar formation inhibition ratio, the higher the tartar formation inhibition effect.

Tartar formation inhibition ratio (%) =100- { OD of substrate treated with the liquid dental cleaning composition obtained above _595nm OD of untreated substrate _595nm }×100

The results are shown in Table 1.

Claims

1. An oral composition, wherein,

comprises the following components (A), (B), (C) and (D):

(A) 6 to 16 mass% of erythritol,

(B) Sodium fluoride 0.1 to 2.5 mass%,

(C) 0.22 to 3.5 mass% of calcium glycerophosphate,

(D) 55 to 93 mass% of water,

the mass ratio (A)/(D) of the content of the component (A) to the content of the component (D) is 0.06 to 0.2,

the mass ratio Ca/F of the calcium atom equivalent of the component (C) to the fluorine atom equivalent of the component (B) is 0.35 to 0.55,

the ratio of the mass ratio Ca/F of the calcium atom equivalent amount of the component (C) to the fluorine atom equivalent amount of the component (B) to the content of the component (A) (Ca/F)/(A) is 0.015 to 0.15, wherein the unit of (Ca/F)/(A) is mass% ^-1 ，

The pH value at 25 ℃ is 6.5-10.0.

2. The oral composition of claim 1, wherein,

the content of anionic surfactant is less than 1 mass%.

3. The oral composition according to claim 1 or 2, wherein,

the mass ratio Ca/F of the calcium atom-converted amount of the component (C) to the fluorine atom-converted amount of the component (B) is 0.38 to 0.52.

4. The oral composition according to claim 1 or 2, wherein,

the total content of the fluorine compounds other than the component (B) and the polyvalent metal salt is less than 0.02 mass%.

5. The oral composition according to claim 1 or 2, wherein,

the mass ratio (C)/(A) of the content of the component (C) to the content of the component (A) is not less than 0.02 and not more than 0.3.

6. The oral composition according to claim 1 or 2, wherein,

the ratio of the mass ratio Ca/F of the calcium atom equivalent amount of the component (C) to the fluorine atom equivalent amount of the component (B) to the content of the component (A) (Ca/F)/(A) is 0.02 to 0.07, wherein the unit of (Ca/F)/(A) is mass% ^-1 。

7. The oral composition according to claim 1 or 2, wherein,

the mass ratio (A)/(D) of the content of the component (A) to the content of the component (D) is 0.08 to 0.2.

8. The oral composition according to claim 1 or 2, wherein,

the mass ratio (A)/(D) of the content of the component (A) to the content of the component (D) is not less than 0.1 and not more than 0.2.

9. The oral composition according to claim 1 or 2, wherein,

the content of the component (A) is 8 to 16 mass%.

10. The oral composition according to claim 1 or 2, wherein,

no abrasive is contained.

11. The oral composition according to claim 1 or 2, wherein,

can be used for treating dentin hypersensitive.

12. The oral composition according to claim 1 or 2, wherein,

is a liquid tooth cleaning composition.

13. Use of an oral composition according to any one of claims 1 to 10 for non-therapeutic purposes in alleviating or preventing dentinal hypersensitivity.

14. Use of the composition for oral cavity according to any one of claims 1 to 10 for non-therapeutic purposes in promoting formation of a fluorine coating film for sealing an opening of a dentinal tubule.