JP6874688B2 - Toothpaste composition and oral biofilm remover - Google Patents

Description

The present invention relates to an oral biofilm removing agent containing an α-olefin sulfonate and a dentifrice composition containing the α-olefin sulfonate, which has an excellent effect of removing an oral biofilm, particularly an effect of removing a biofilm in a gap between teeth.

In general, the dental caries biofilm in the oral cavity is known to be an aggregate of bacteria, and in order to remove the oral biofilm, it is necessary to disperse and remove the aggregate of bacteria. is important.
Biofilms exist not only on the surface of the dentition but also in the gaps between teeth, and if such biofilms between teeth can be dispersed and removed, it will have the effect of preventing or suppressing oral diseases such as dental caries and periodontal disease. Although further improvement can be expected, it was difficult to satisfactorily remove the biofilm in the narrow gap between teeth.

Α-olefin sulfonates such as sodium tetradecenesulfonate, which is an anionic surfactant, have a weak oral biofilm removing effect, but the effect is not sufficient. As a technique for improving the oral biofilm removing effect of α-olefin sulfonate, Patent Document 1 (Japanese Patent Laid-Open No. 2015-20970) in which α-olefin sulfonate and dextranase are used in combination, α-olefin sulfonate Patent Document 2 (Japanese Unexamined Patent Publication No. 2013-151474) in which an acylamino acid salt and / or arginine is used in combination has been proposed, but the removal of a biofilm between teeth has not been studied.

Japanese Unexamined Patent Publication No. 2015-20970 Japanese Unexamined Patent Publication No. 2013-151474 Japanese Unexamined Patent Publication No. 2014-944923 JP-A-2015-117206

Therefore, in the oral composition, it has been desired to improve the effect of removing the biofilm between the teeth.

The present invention has been made in view of the above circumstances, and an α-olefin sulfonate-containing oral biofilm remover having an excellent oral biofilm removing effect, particularly a removing effect on the biofilm in the gap between teeth, and an oral biofilm removing agent thereof. It is an object of the present invention to provide a dentifrice composition containing.

As a result of diligent studies to achieve the above object, the present inventors have added (B) water-insoluble granules having an average particle size of 50 to 400 μm, particularly silica granules, to (A) α-olefin sulfonate. It was found that when used in combination, the biofilm removing effect on the biofilm in the gap between teeth is particularly excellent, and it is effective as an oral biofilm removing agent. Further, by blending the components (A) and (B) in the dentifrice composition, the effect of removing the oral biofilm is improved, and the effect of removing the biofilm in the gap between the teeth is particularly excellent, and the tooth surface It has been found that a smooth feeling is satisfactorily given and a high cleaning feeling is given, and the present invention has been made.

More specifically, in the oral composition, especially in the dentin composition, which is used in a relatively small amount of about 1 g and is diluted with saliva during use in the oral cavity, so that it is difficult to fully exert its medicinal effect. , The biofilm removing effect of α-olefin sulfonate is not sufficient, and if the compounding amount is increased in order to enhance the effect, the taste of the preparation becomes worse and the tongue becomes irritated. In addition, although the water-insoluble granules can be expected to have physical cleaning power, the biofilm removing effect due to the water-insoluble granules is not sufficient, and on the other hand, as the amount of the added amount increases, the discomfort when brushing teeth becomes stronger and the usability deteriorates. In addition, there are problems with usability, such as the formulation becoming hard and difficult to extrude from the container. On the other hand, in the present invention, when the component (B) is combined with the component (A), surprisingly, both components act synergistically without causing the above-mentioned problems of usability and usability. In particular, the biofilm removing effect on the gap between teeth is improved, and at the same time, it is possible to satisfactorily give a smooth feeling that the tooth surface is sufficiently cleaned by brushing the teeth. In this case, the combination of the components (A) and (B) remarkably enhances the biofilm removing effect beyond the single use of the α-olefin sulfonate or the water-insoluble granules, and gives the above-mentioned exceptionally remarkable action and effect.
Therefore, according to the present invention, it is said that the excellent biofilm removing effect of removing not only the tooth surface of the dentition but also the biofilm existing in the gap between the teeth and the tooth surface being sufficiently cleaned by tooth brushing. It is possible to give a satisfactory feeling of effect at the same time.

In addition, Patent Documents 3 and 4 (Japanese Patent Laid-Open No. 2014-944923, Japanese Patent Application Laid-Open No. 2015-117206) describe the improvement of the ability to remove plaque and stains and the foaming performance by specific dentifrice granules. There is no description of combining granules with α-olefin sulfonate. From Patent Documents 3 and 4, it cannot be recalled that the biofilm removing effect is synergistically improved by combining the α-olefin sulfonate and the water-insoluble granules.

Therefore, the present invention provides the following dentifrice composition and oral biofilm remover.
[1]
A dentifrice composition comprising (A) an α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm.
[2]
(B) The dentifrice composition according to [1], wherein the average particle size of the component is 50 to 250 μm.
[3]
The dentifrice composition according to [1] or [2], wherein the water-insoluble granules of the component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
[4]
The dentifrice composition according to [3], wherein the water-insoluble granules of the component (B) are silica granules having an average particle size of 80 to 150 μm and an average disintegration strength of 10 to 50 g / piece.
[5]
The dentifrice composition according to any one of [1] to [4], which contains 0.05 to 1.5% by mass of the component (A) and 0.1 to 10% by mass of the component (B).
[6]
The dentifrice composition according to any one of [1] to [5], wherein (B) / (A) has a mass ratio of 1 to 60.
[7]
The dentifrice composition according to any one of [1] to [6], which further contains (C) a binder in an amount of 0.1 to 5% by mass.
[8]
(C) The dentifrice composition according to [7], wherein the binder contains at least xanthan gum.
[9]
An oral biofilm remover comprising (A) an α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm.
[10]
The oral biofilm remover according to [9], wherein the water-insoluble granules of the component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
[11]
The oral biofilm remover according to [9] or [10], wherein (B) / (A) has a mass ratio of 1 to 60.

According to the present invention, α-olefin sulfonic acid has an excellent oral biofilm removing effect, particularly a removing effect on the biofilm in the gap between teeth, and gives a satisfactory feeling of smoothness on the tooth surface to give a high cleaning feeling. A salt-containing dentifrice composition and an oral biofilm remover can be provided.

Hereinafter, the present invention will be described in more detail. In the oral biofilm remover and dentifrice composition of the present invention, (A) α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm are used in combination.

As the α-olefin sulfonic acid salt (A), an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and α-olefin sulfonic acid having 14 carbon atoms is preferable. Salts, especially sodium salts (generic name; sodium tetradecene sulfonate). Commercially available products that can be used for oral preparations can be obtained for these, and for example, the trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

The component (B) is a water-insoluble granule having an average particle size of 50 to 400 μm, and a preferable average particle size is 50 to 300 μm, particularly 50 to 250 μm, and particularly 80 to 150 μm. When the average particle size is less than 50 μm, the biofilm removing effect on the gap between teeth is inferior, and the effect of imparting a smooth feeling on the tooth surface is inferior. If it exceeds 400 μm, the biofilm removing effect on the gap between teeth is reduced.
The average particle size was measured using a particle size distribution measuring device (Microtrak particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium; water), and the measured value was the median diameter (d50) using the volume average. Calculated (same below).

Further, as the water-insoluble granules, disintegrant granules can be used, and the average disintegration strength thereof is preferably 10 to 200 g / piece, more preferably 10 to 50 g / piece. The larger the average disintegration strength, the better the cleaning property and the biofilm removing effect, but 200 g / piece or less is suitable for suppressing discomfort during tooth brushing.
The average decay strength is the automatic breaking strength measurement value (when one granule is compressed at a rate of 10 mm / min) for every 30 granules by a leometer (Sun Leometer CR-200D manufactured by Sun Science Co., Ltd.). It is the average value of the measured values (load when the granules disintegrate).

As the water-insoluble granules of the component (B), dentifrice granules having the above physical characteristics can be used, but silica granules are particularly preferable. For example, a commercially available product such as the trade name NIPGEL manufactured by Tosoh Silica Co., Ltd. can be used.

The mass ratios of (B) / (A) indicating the mixing ratio of (A) α-olefin sulfonate and (B) specific water-insoluble granules are preferably 1 to 60, particularly 1.3 to 60, more preferably. It is preferably 1.5 to 40, particularly preferably 2 to 30. Within this range, the oral biofilm removing effect is more excellent.

The oral biofilm remover of the present invention is suitably blended in oral compositions, particularly dentifrice compositions.
In this case, the blending amount of the α-olefin sulfonate of the component (A) is preferably 0.05 to 1.5% (mass%, the same applies hereinafter) of the entire composition, and more preferably 0.1 to 1. It is .1%, more preferably 0.2 to 1%. The larger the blending amount, the better the biofilm removing effect, and when it is 0.05% or more, the biofilm removing effect on the gap between the teeth is sufficiently excellent, and the smooth feeling of the teeth can be sufficiently imparted. When it is 1.5% or less, it is possible to sufficiently prevent the bitterness and the tingling stimulus of the tongue.

The blending amount of the water-insoluble granules of the component (B) is preferably 0.1 to 10%, more preferably 0.4 to 8%, and even more preferably 1 to 8% of the entire composition. The larger the amount, the better the biofilm removing effect and the tooth slippery effect, and when it is 0.1% or more, the biofilm removing effect on the gap between teeth is sufficiently excellent, and the tooth smoothness is felt. Can be given sufficiently. If it is 10% or less, it is possible to prevent a feeling of strangeness during use.

Further, in the present invention, the binder (C) is preferably blended. When the binder is added, the foam retention is improved, so that the dispersibility of the water-insoluble granules of the component (B) is enhanced, and the biofilm removing effect and the tooth smoothness imparting effect are further improved.
Examples of the binder include gums such as xanthan gum, carrageenan, sodium alginate, sodium polyacrylate, sodium carboxymethyl cellulose and the like, but at least xanthan gum is preferably contained.
When the binder is blended, the blending amount with respect to the entire composition is preferably 0.1 to 5%, more preferably 0.2 to 3%.

The dentifrice composition of the present invention can be prepared in the form of a liquid, liquid, paste or the like as a dentifrice, a liquid dentifrice, a liquid dentifrice, a dentifrice, or the like, particularly as a dentifrice. In this case, in addition to the above components, other optional components according to the dosage form and the like can be appropriately blended as long as the effects of the present invention are not impaired. Specifically, in the dentifrice, an abrasive other than the component (B), a thickener, a surfactant other than the component (A), and if necessary, a sweetener, a preservative, a pigment, a fragrance, various active ingredients, etc. are blended. Can be.

Specifically, as the polishing agent, a silica-based polishing agent such as precipitated silica, aluminosilicate, and zirconosilicate, a calcium phosphate-based polishing agent such as calcium secondary phosphate, calcium tertiary phosphate, calcium tetraphosphate, and calcium phosphate 8 and light calcium carbonate. , Calcium carbonate-based abrasives such as heavy calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, polymethylmethacrylate, insoluble calcium metaphosphate, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, hydroxy Examples include apatite, fluoroapatite, and calcium-deficient apatite. When these abrasives are blended, the blending amount with respect to the entire composition is preferably 5 to 60%, more preferably 10 to 30%.

Examples of the thickener include sugar alcohols such as sorbitol, xylit and erythritol, and polyhydric alcohols such as propylene glycol, butylene glycol, glycerin and polyethylene glycol. The blending amount of the thickener is usually 0 to 70% of the total composition, particularly 3 to 50%.

Examples of the surfactant include anionic surfactants other than the component (A), amphoteric surfactants, nonionic surfactants and the like.
For example, examples of the anionic surfactant include lauryl sulfate, myristyl sulfate, polyoxyethylene alkyl sulfate, N-lauryl taurine salt, lauroyl sarcosine salt and the like, and sodium salt is preferable as the salt because of its solubility and the like. Is. Examples of the amphoteric tenside include N-acylglutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, fatty acid amide propyl betaine, and the like, and the chain length of the fatty acid has 12 to 14 carbon atoms. Is preferable in terms of solubility. Examples of nonionic surfactants include polyoxyethylene alkyl ether, alkyl glycoside, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, fatty acid polyglyceryl, and polyoxyethylene curing. Castor oil and the like can be mentioned.
The blending amount of these surfactants is preferably 0 to 10%, particularly 0.1 to 5% of the total composition.

Examples of the sweetening agent include sodium saccharin and the like. Examples of the preservative include benzoates such as sodium benzoate and paraoxybenzoic acid esters such as methylparaben, ethylparaben and butylparaben.
Examples of the pigment include edible pigments such as brilliant blue and tartrazine, and pigments such as titanium oxide.

As fragrances, peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder Fragrances (such as fragrances) and l-menthol, carboxylic, anator, cineole, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timol, linalol, linaryl acetate, Limonen, Menton, Menthyl Acetate, N-Substituted-Paramentan-3-Carboxamide, Peppermint, Octylaldehyde, Citral, Pregon, Calvier Acetate, Anisaldehyde, Ethyl Acetate, Ethyl Butyrate, Allyl Cyclohexane Propionate, Methyl Anthranilate , Ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, ethylthioacetate and other single flavors, as well as strawberry flavor and apple flavor. , Banana flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, tropical fruit flavors, and other blended flavors that can be used in combination with known flavoring materials used in toothpaste compositions. it can. Further, the blending amount is not particularly limited, but it is preferable to use 0.000001 to 1% of the above-mentioned fragrance material in the composition. The perfume for perfume using the above perfume material is preferably used in an amount of 0.1 to 2% in the composition.

Examples of the active ingredient include bactericidal or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, zinc gluconate, zinc citrate, and tooth stones such as ethanehydroxydiphosphate. Preventive agents, tranexamic acid, glycyrrhizic acid and its salts, anti-inflammatory agents such as allantinchlorohydroxyaluminum, coating agents such as hydroxyethyl cellulosedimethyldialylammonium chloride, enzyme agents such as dextranase, mutanase, lysoteam chloride, ascorbic acid, acetic acid. Drugs such as vitamins such as tocopherol, astringents such as sodium chloride, hypersensitivity inhibitors such as aluminum lactate, strontium chloride and potassium nitrate, and fluorides such as sodium fluoride, sodium monofluorophosphate and stannous fluoride It can be used within a scientifically acceptable range.

The dentifrice composition is generally in the range of pH 6 to 10, particularly pH 6 to 9, and is preferably in the above range in the present invention.
The pH of the composition may be adjusted using a pH adjuster. Acidity regulators include acetic acid, hydrochloric acid, sulfuric acid, nitrate, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamate, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, citric acid. An appropriate amount of an acid or alkali such as sodium, sodium hydrogen citrate, sodium phosphate, sodium hydrogen phosphate or the like can be blended.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are also shown in the table.
The average particle size of the granules was measured using a particle size distribution measuring device (Microtrak particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium; water), and the measured value was the median diameter (d50) using the volume average. Calculated in. The average decay strength is the automatic breaking strength measurement value for each of 30 granules (when one granule is compressed at a rate of 10 mm / min) by a leometer (Sun Leometer CR-200D manufactured by Sun Scientific Co., Ltd.). It is the average value of the measured values (load when collapsing).

<Evaluation method of biofilm removal effect on the gap between teeth>
(1) Method for producing model biofilm A model biofilm obtained by treating untreated hydroxyapatite (HA) pellets having a width of 1 mm and a depth of 1 mm with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours. It was used as a carrier for preparation and installed on the bottom of a 24-hole multi-plate (manufactured by Sumitomo Bakelite Co., Ltd.). As the culture broth, basal medium mucin culture broth (BMM) ^{* 1} was used.
Strain used to make the model biofilm, Actinomyces Visukosasu (Actinomyces viscosus) ATCC43146 purchased from American Type Culture Collection, Veillonella Parubyura (Veillonella parvula) ATCC17745, Fusobacterium nucleatum (Fusobacterium nucleatum) ATCC10953, Streptococcus oralis (Streptococcus Oralis) ATCC10557 and Streptococcus mutans ATCC25175 were used. These 5 strains were inoculated into a Rotating Disk Reactor (culture tank) containing 3,000 mL of BMM in advance at 1 × 10 ⁷ cfu / mL (cfu: colony forming units), and at 37 ° C. together with a saliva-treated HA carrier. The cells were cultured under anaerobic conditions (5 vol% carbon dioxide, 95 vol% nitrogen) for 24 hours. Then, under the same conditions, BMM medium was continuously supplied at a substitution rate of 5 vol% / hour and cultured for 10 days to form a model biofilm containing 5 strains on the surface of HA.

* 1 BMM composition: Expressed as the mass in 1 liter.
Proteose peptone (manufactured by Becton and Dickinson): 4 g / L
Tryptone (manufactured by Becton and Dickinson):
2g / L
Yeast extract (manufactured by Becton and Dickinson):
2g / L
Mucin (manufactured by Sigma-Aldrich Japan): 5 g / L
Hemin (manufactured by Sigma-Aldrich Japan): 2.5 mg / L
Vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.): 0.5 mg / L
KCl (manufactured by Wako Pure Chemical Industries, Ltd.): 1 g / L
Cysteine (manufactured by Wako Pure Chemical Industries, Ltd.): 0.2 g / L
Distilled water: Residual (Messed up to a total volume of 1 L and autoclaved at 121 ° C for 20 minutes.)

(2) Effect of removing model biofilm A white sticker was attached to the portion other than the gap of HA before forming the biofilm, and the value measured by the color difference meter was used as the reference color for the gap portion as L0. After peeling off the sticker and forming a biofilm by the above method, a white sticker was attached again to the portion other than the gap of HA, and the value measured by the color difference meter in the gap portion was defined as L1. The seal was peeled off, and the HA surface was brushed 20 times with a toothbrush containing 1 g of the prepared dentifrice, then lightly washed with running water and dried. A white sticker was attached to the portion other than the HA gap again, and the value measured by the color difference meter in the gap was defined as L2. The biofilm removal rate was calculated by the following formula, and the average value of 10 times was evaluated according to the following evaluation criteria, and the biofilm removal effect on the gap between teeth was judged from this evaluation result.
Biofilm removal rate (%) =
[(L1-L2) / (L1-L0)] × 100
Evaluation criteria ⊚: Biofilm removal rate is 80% or more ○: Biofilm removal rate is 60% or more and less than 80% Δ: Biofilm removal rate is 40% or more and less than 60% ×: Biofilm removal rate is less than 40%

<Evaluation method for smoothness of teeth>
Using 10 subjects, 1 g of the dentifrice composition was placed on a toothbrush, and the smoothness of the teeth after brushing was judged according to the following scoring criteria. The average value of 10 people was calculated and evaluated according to the following evaluation criteria.
Here, the smooth feeling of the teeth is a smooth feeling that the tooth surface is sufficiently cleaned and cleaned by brushing the teeth when the tongue is brought into contact with the tooth surface.
Rating criteria 5: Very slippery teeth 4: Very slippery teeth 3: Slightly slippery teeth 2: Slightly slippery teeth 1: No slippery teeth Evaluation Criteria ◎: Average value is 4.0 points or more and 5.0 points or less ○: Average value is 3.0 points or more and less than 4.0 points Δ: Average value is 2.0 points or more and less than 3.0 points ×: Average value Is less than 2.0 points

＊；参考例

*; Reference example

＊；参考例

*; Reference example

As shown in the comparative examples in Table 3, the biofilm removing effect on the tooth-to-tooth gap was low with sodium tetradecenesulfonate alone or granules alone. In addition, when inappropriate granules were combined with sodium tetradecene sulfonate, the biofilm removing effect on the gap between teeth was not improved and was inferior. On the other hand, the dentifrice composition (Example) in which the components (A) and (B) of the present invention shown in Tables 1 and 2 are used in combination has a biofilm removing effect on the gap between teeth and a smooth feeling of teeth. Was excellent.

Details of the raw materials used are shown below.
(A) Sodium tetradecene sulfonate;
Made by Lion Specialty Chemicals Co., Ltd., trade name K Liporan PJ-400CJ
(B) Granules; manufactured by Tosoh Silica Co., Ltd., trade name NIPGEL,
Average disintegration strength 10 to 50 g / piece Granule B1: AY grade is classified by sieving, and the average particle size is 100 μm.
Collected to be m.
Granule B2: AY grade is classified by sieving, and the average particle size is 80 μm.
Collected to be.
Granule B3: Classify AY grade by sieving and average particle size 150μ
Collected to be m.
Granule B4: AY grade is classified by sieving, and the average particle size is 300μ.
Collected to be m.
Granule B5: Classify AY grade by sieving and average particle size 500μ
Collected to be m (comparative product).
Granule B6: AY grade is classified by sieving, and the average particle size is 40 μm.
Collected to be (comparative product).
Silicic anhydride (abrasive silica); manufactured by Taki Chemical Co., Ltd., average particle size 20 μm

Claims (10)

(A) α-olefin sulfonate and
(B) contains water-insoluble granules having an average particle size of 50 to 150 μm, the content of the component (A) is 0.2 to 1.5% by mass, and (B) / (A) is mass. A dentifrice composition characterized by a ratio of 2.7 to 27. The dentifrice composition according to claim 1, wherein the average particle size of the component (B) is 80 to 150 μm. The dentifrice composition according to claim 1 or 2, wherein the water-insoluble granules of the component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece. The dentifrice composition according to claim 3, wherein the water-insoluble granules of the component (B) are silica granules having an average disintegration strength of 10 to 50 g / piece. (B) The dentifrice composition according to any one of claims 1 to 4, which contains 1 to 10% by mass of the component. The dentifrice composition according to any one of claims 1 to 5 , further comprising (C) 0.1 to 5% by mass of a binder. (C) The dentifrice composition according to claim 6 , wherein the binder contains at least xanthan gum. The dentifrice composition according to any one of claims 1 to 7 , which is used for removing an oral biofilm. It contains (A) α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 150 μm, and the content of the component (A) is 0.2 to 1.5% by mass. An oral biofilm remover having (B) / (A) having a mass ratio of 2.7 to 27. The oral biofilm remover according to claim 9 , wherein the water-insoluble granules of the component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.