WO2017094580A1

WO2017094580A1 - Toothpaste composition and oral biofilm removing agent

Info

Publication number: WO2017094580A1
Application number: PCT/JP2016/084774
Authority: WO
Inventors: 和晃小島; 山本　幸司; 友一小熊; 祐貴猪谷
Original assignee: ライオン株式会社
Priority date: 2015-11-30
Filing date: 2016-11-24
Publication date: 2017-06-08
Also published as: JPWO2017094580A1; JP6874688B2

Abstract

Provided is an oral biofilm removing agent that has an excellent effect of removing an oral biofilm, in particular, an effect of removing a biofilm formed in a gap between teeth, said oral biofilm removing agent comprising: (A) an α-olefin sulfonic acid salt; and (B) water-insoluble granules having an average grain size of 50-400 μm. Also provided is a tooth paste composition that comprises the aforesaid components (A) and (B).

Description

Dentifrice composition and oral biofilm remover

The present invention relates to an α-olefin sulfonate-containing oral biofilm remover and a dentifrice composition containing the same, which are excellent in removing the oral biofilm, particularly the removal effect on the biofilm in the gap between teeth.

In general, it is known that the caries biofilm in the oral cavity is an aggregate of bacteria, and in order to remove the oral biofilm, the aggregate of bacteria can be dispersed and removed. is important.
Biofilms exist not only in the dentition surface but also in the gap between teeth, and if such interdental biofilms can also be dispersed and removed, it can prevent or suppress oral diseases such as caries and periodontal disease. Although further improvement can be expected, it was difficult to satisfactorily remove the biofilm in the narrow gap between the teeth.

An α-olefin sulfonate such as sodium tetradecene sulfonate, which is an anionic surfactant, has a weak oral biofilm removal effect, but the effect is not sufficient. As a technique for improving the oral biofilm removal effect of α-olefin sulfonate, Patent Document 1 (Japanese Patent Laid-Open No. 2015-20970) using α-olefin sulfonate and dextranase in combination, α-olefin sulfonate Patent Document 2 (Japanese Patent Laid-Open No. 2013-151474) in which an acylamino acid salt and / or arginine is used in combination has been proposed, but biofilm removal at the gap between teeth has not been studied.

Japanese Patent Laying-Open No. 2015-20970 JP 2013-151474 A JP 2014-94923 A JP 2015-117206 A

Therefore, in the composition for oral cavity, it is desired to improve the removal effect on the biofilm of the gap between teeth.

The present invention was made in view of the above circumstances, and has an oral biofilm removal effect, in particular, an excellent removal effect on the biofilm in the gap between teeth, and an oral biofilm removal agent containing α-olefin sulfonate and the same. It aims at providing the dentifrice composition containing.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) α-olefin sulfonate has (B) water-insoluble granules having an average particle diameter of 50 to 400 μm, particularly silica granules. It has been found that when used in combination, the biofilm removal effect on the biofilm in the gap between the teeth is particularly excellent and effective as an oral biofilm remover. Further, by blending the components (A) and (B) into the dentifrice composition, the oral biofilm removal effect is improved, and in particular, the removal effect on the biofilm in the gap between teeth is excellent, and the tooth surface The inventors have found that a smooth feeling is imparted satisfactorily and a high cleaning feeling is given, and the present invention has been made.

More specifically, in an oral composition, in particular a dentifrice composition with a relatively low usage amount of about 1 g per dose and difficult to exert its medicinal effects sufficiently because it is diluted with saliva during use in the oral cavity. However, the biofilm removal effect by α-olefin sulfonate is not sufficient, and if the amount is increased in order to enhance the effect, the taste of the preparation becomes worse, and it becomes easy to feel irritation such as a tingling of the tongue. Although water-insoluble granules can be expected to have a physical cleaning power, the resulting biofilm removal effect is not sufficient. On the other hand, as the amount added increases, the feeling of discomfort during brushing becomes stronger and the feeling of use decreases. Or the problem of usability occurs that the preparation becomes hard and difficult to push out from the container. On the other hand, in the present invention, when the component (B) is combined with the component (A), both the components unexpectedly act synergistically without causing the above-mentioned feeling of use and usability. In particular, the effect of removing the biofilm with respect to the gap between the teeth can be improved, and at the same time, a smooth sensation that allows the user to feel that the tooth surface has been sufficiently cleaned by brushing can be satisfactorily imparted. In this case, the combination of the components (A) and (B) significantly increases the biofilm removal effect over the single use of the α-olefin sulfonate or the water-insoluble granule, and gives the above-mentioned remarkable effects.
Therefore, according to the present invention, not only the tooth surface of the dentition but also the biofilm removal effect that removes even the biofilm present in the gap between the teeth, and the tooth surface is sufficiently cleaned by tooth brushing. It is possible to simultaneously provide a satisfactory effect feeling.

Patent Documents 3 and 4 (Japanese Unexamined Patent Application Publication Nos. 2014-94923 and 2015-117206) are improvements in the ability to remove plaque and dirt and foam performance by using specific dentifrice granules. In particular, there is no description of combining granules with α-olefin sulfonate. From Patent Documents 3 and 4, it cannot be recalled that the biofilm removal effect is synergistically improved by combining α-olefin sulfonate and water-insoluble granules.

Accordingly, the present invention provides the following dentifrice composition and oral biofilm remover.
[1]
A dentifrice composition comprising (A) an α-olefin sulfonate and (B) water-insoluble granules having an average particle diameter of 50 to 400 μm.
[2]
The dentifrice composition according to [1], wherein the average particle size of the component (B) is 50 to 250 μm.
[3]
The dentifrice composition according to [1] or [2], wherein the water-insoluble granules as component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
[4]
The dentifrice composition according to [3], wherein the water-insoluble granules as the component (B) are silica granules having an average particle size of 80 to 150 μm and an average disintegration strength of 10 to 50 g / piece.
[5]
The dentifrice composition according to any one of [1] to [4], containing 0.05 to 1.5% by mass of component (A) and 0.1 to 10% by mass of component (B).
[6]
The dentifrice composition according to any one of [1] to [5], wherein (B) / (A) is 1 to 60 in terms of mass ratio.
[7]
The dentifrice composition according to any one of [1] to [6], further comprising (C) 0.1 to 5% by mass of a binder.
[8]
(C) The dentifrice composition according to [7], wherein the binder contains at least xanthan gum.
[9]
An oral biofilm remover comprising (A) an α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm.
[10]
The oral biofilm remover according to [9], wherein the water-insoluble granules as component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
[11]
The oral biofilm remover according to [9] or [10], wherein (B) / (A) is 1 to 60 in terms of mass ratio.

According to the present invention, α-olefin sulfonic acid has excellent oral biofilm removal effect, particularly removal effect on the biofilm in the gap between teeth, and provides a high cleaning feeling by satisfactorily imparting a smooth surface to the tooth surface. A salt-containing dentifrice composition and an oral biofilm remover can be provided.

Hereinafter, the present invention will be described in further detail. The oral biofilm remover and dentifrice composition of the present invention use (A) α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm.

(A) As the α-olefin sulfonate, an alkali metal salt such as sodium or potassium of an α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably an α-olefin sulfonic acid having 14 carbon atoms. Salts, especially sodium salts (generic name; sodium tetradecenesulfonate). Commercially available products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

The component (B) is a water-insoluble granule having an average particle size of 50 to 400 μm, and a preferable average particle size is 50 to 300 μm, particularly 50 to 250 μm, especially 80 to 150 μm. When the average particle size is less than 50 μm, the biofilm removing effect on the gap between the teeth is inferior, and the smoothness imparting effect on the tooth surface is inferior. When it exceeds 400 μm, the effect of removing the biofilm with respect to the gap between the teeth decreases.
The average particle diameter is measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium; water), and the measured value is a median diameter (d50) using a volume average. Calculated (the same applies hereinafter).

Furthermore, disintegrable granules can be used as the water-insoluble granules, and the average disintegration strength is preferably 10 to 200 g / piece, more preferably 10 to 50 g / piece. The greater the average disintegration strength, the better the cleaning property and the biofilm removal effect, but 200 g / piece or less is suitable for suppressing discomfort during brushing.
The average disintegration strength is determined by measuring automatically breaking strength of 30 granules (one granule is compressed at a speed of 10 mm / min) with a rheometer (Sun Rheometer CR-200D manufactured by Sun Science Co., Ltd.). It is the average value of the values measured for the load when the granules disintegrate.

As the water-insoluble granule of component (B), a granule for dentifrice having the above physical properties can be used, and silica granule is particularly suitable. For example, a commercial product such as NIPGEL manufactured by Tosoh Silica Co., Ltd. can be used.

(B) / (A) showing the blending ratio of (A) α-olefin sulfonate and (B) specific water-insoluble granules is preferably 1 to 60, particularly preferably 1.3 to 60, as the mass ratio. Preferably it is 1.5 to 40, particularly preferably 2 to 30. Within this range, the oral biofilm removal effect is more excellent.

The oral biofilm remover of the present invention is suitably blended in an oral composition, particularly a dentifrice composition.
In this case, the blending amount of the α-olefin sulfonate of component (A) is preferably 0.05 to 1.5% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.1 to 1 0.1%, more preferably 0.2 to 1%. The greater the amount, the better the biofilm removal effect. If it is 0.05% or more, the biofilm removal effect for the gap between the teeth is sufficiently excellent, and the tooth's smoothness can be sufficiently imparted. If it is 1.5% or less, it is possible to sufficiently prevent the bitter taste and the irritation of the tongue from being felt.

The blending amount of the water-insoluble granule of the component (B) is preferably 0.1 to 10%, more preferably 0.4 to 8%, still more preferably 1 to 8% of the entire composition. The greater the blending amount, the better the biofilm removal effect and the tooth-smoothness-imparting effect. When it is 0.1% or more, the biofilm removal effect for the gap between teeth is sufficiently excellent, and the tooth-smooth feeling Can be sufficiently provided. When it is 10% or less, it is possible to prevent the user from feeling uncomfortable during use.

Furthermore, in the present invention, (C) a binder is suitably blended. When the binder is blended, the foam retention is improved, so that the dispersibility of the water-insoluble granules of the component (B) is enhanced, and the biofilm removal effect and the tooth smoothness imparting effect are further improved.
Examples of the binder include gums such as xanthan gum, carrageenan, sodium alginate, sodium polyacrylate, sodium carboxymethyl cellulose, and the like, but it is preferable that at least xanthan gum is included.
When the binder is blended, the blending amount with respect to the entire composition is preferably 0.1 to 5%, more preferably 0.2 to 3%.

The dentifrice composition of the present invention can be prepared in the form of a liquid, liquid, paste or the like as a toothpaste, liquid dentifrice, liquid dentifrice, moisturized dentifrice or the like, and particularly as a toothpaste. In this case, in addition to the above components, other optional components according to the dosage form and the like can be appropriately blended within a range not impeding the effects of the present invention. Specifically, the toothpaste contains a polishing agent other than the component (B), a thickening agent, a surfactant other than the component (A), and if necessary, a sweetener, an antiseptic, a pigment, a fragrance, and various active ingredients. Can do.

Specific examples of the abrasive include silica-based abrasives such as precipitated silica, aluminosilicate and zirconosilicate, calcium phosphate-based abrasives such as dicalcium phosphate, tricalcium phosphate, quaternary calcium phosphate and eighth calcium phosphate, and light calcium carbonate. , Calcium carbonate-based abrasives such as heavy calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, polymethyl methacrylate, insoluble calcium metaphosphate, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, hydroxy Examples include apatite, fluoroapatite, and calcium deficient apatite. When these abrasives are blended, the blending amount with respect to the entire composition is preferably 5 to 60%, more preferably 10 to 30%.

Examples of the thickener include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as propylene glycol, butylene glycol, glycerin and polyethylene glycol. The blending amount of the thickener is usually 0 to 70%, particularly 3 to 50% of the whole composition.

Examples of the surfactant include anionic surfactants other than the component (A), amphoteric surfactants, nonionic surfactants, and the like.
For example, examples of the anionic surfactant include lauryl sulfate, myristyl sulfate, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, and lauroyl sarcosine salt. Sodium salt is preferable because of its solubility. It is. Examples of amphoteric surfactants include N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, fatty acid amidopropyl betaine, and the like. The fatty acid chain length is 12 to 14 carbon atoms. Are preferable from the viewpoint of solubility. Nonionic surfactants include, for example, polyoxyethylene alkyl ethers, alkyl glycosides, sucrose fatty acid esters, alkylol amides, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, fatty acid polyglyceryl, polyoxyethylene cured Castor oil and the like.
The blending amount of these surfactants is preferably 0 to 10%, particularly 0.1 to 5% of the whole composition.

Examples of the sweetening agent include saccharin sodium. Examples of the preservative include benzoates such as sodium benzoate, and paraoxybenzoates such as methyl paraben, ethyl paraben, and butyl paraben.
Examples of the dye include edible dyes such as brilliant blue and tartrazine, and pigments such as titanium oxide.

Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and l-ment , Caroline, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1,2-diol, Thymol, Linalol, Linaryl acetate, Limonene, Menthone, Menthyl acetate, N-Substituted Paramentan-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undeca Lactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, Toothpaste composition, such as single flavors such as tilthioacetate, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can use combining the well-known perfume material used for a thing. Also, the blending amount is not particularly limited, but the above fragrance material is preferably used in the composition in an amount of 0.000001 to 1%. It is preferable to use 0.1 to 2% of the flavoring fragrance using the above fragrance material in the composition.

Examples of active ingredients include antibacterial or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, zinc gluconate and zinc citrate, and tartars such as ethanehydroxydiphosphonate. Prophylactic agents, tranexamic acid, glycyrrhizic acid and its salts, anti-inflammatory agents such as allantochlorohydroxyaluminum, coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride, enzyme agents such as dextranase, mutanase, lysozyme chloride, ascorbic acid, acetic acid Vitamins such as tocopherol, astringents such as sodium chloride, hypersensitivity inhibitors such as aluminum lactate, strontium chloride, potassium nitrate, sodium fluoride, monofluoro Sodium phosphate, and the like fluoride such as stannous fluoride, can be used in pharmaceutically acceptable range.

The dentifrice composition is generally used in a pH range of 6 to 10, particularly in the range of pH 6 to 9, and is preferably within the above range in the present invention.
The pH of the composition may be adjusted using a pH adjuster. pH adjusters include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, citric acid An appropriate amount of an acid or alkali such as sodium, sodium hydrogen citrate, sodium phosphate, or sodium hydrogen phosphate can be blended.

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in the table.
The average particle size of the granules is measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water), and the measured value is the median diameter using volume average (d50). Calculated with The average disintegration strength was measured with a rheometer (Sun Rheometer CR-200D, manufactured by Sun Science Co., Ltd.) for each of 30 granules. This is the average value of the measured values of the load when collapsing.

<Evaluation method of biofilm removal effect for tooth gap>
(1) Model biofilm production method Model biofilm obtained by treating untreated hydroxyapatite (HA) pellets with a gap of 1 mm in width and 1 mm in depth with human unstimulated saliva filtered through a 0.45 μm filter for 4 hours It used for the production | generation carrier and installed in the bottom part of 24 hole multiplate (Sumitomo Bakelite Co., Ltd. product). As a culture solution, a basal medium mucin culture solution (BMM) ^{* 1} was used.
The strains used to make the model biofilms were Actinomyces viscosus ATCC 43146, Baylonella parvula ATCC1745, ATCC1745, ATCC1745, ATCC1745. oralis) ATCC 10557, Streptococcus mutans ATCC 25175. These 5 strains were inoculated to 1 × 10 ⁷ cfu / mL (cfu: colony forming units) in a Rotating Disk Reactor (culture tank) containing 3,000 mL of BMM in advance, and 37 ° C. with a saliva-treated HA carrier. The cells were cultured for 24 hours under anaerobic conditions (5 vol% carbon dioxide gas, 95 vol% nitrogen). Thereafter, a BMM medium was continuously supplied under the same conditions at a substitution rate of 5 vol% / hour and cultured for 10 days to form a model biofilm of 5 strains mixed on the HA surface.

* 1 Composition of BMM: Expressed by mass in 1 liter.
Proteose peptone (Becton and Dickinson): 4g / L
Tryptone (Becton and Dickinson):
2g / L
Yeast extract (Becton and Dickinson):
2g / L
Mucin (Sigma Aldrich Japan): 5g / L
Hemin (Sigma Aldrich Japan): 2.5mg / L
Vitamin K (Wako Pure Chemical Industries, Ltd.): 0.5mg / L
KCl (Wako Pure Chemical Industries, Ltd.): 1g / L
Cysteine (Wako Pure Chemical Industries, Ltd.): 0.2 g / L
Distilled water: Residue (Measured up to a total volume of 1 L and autoclaved at 121 ° C. for 20 minutes.)

(2) Removal effect of model biofilm A white seal was applied to a portion other than the HA gap before the biofilm was formed, and a value obtained by measuring the gap portion with a color difference meter was defined as L0. After the seal was peeled off and a biofilm was formed by the above method, a white seal was again applied to a portion other than the gap of HA, and a value obtained by measuring the gap with a color difference meter was defined as L1. The seal was peeled off, and the HA surface was brushed 20 times with a toothbrush on which 1 g of the prepared dentifrice was placed, and then lightly washed with running water and dried. A white seal was again applied to a portion other than the gap of the HA, and a value obtained by measuring the gap with a color difference meter was defined as L2. The biofilm removal rate was calculated according to the following formula, and the average value of 10 times was evaluated according to the following evaluation criteria. From this evaluation result, the biofilm removal effect on the gap between teeth was determined.
Biofilm removal rate (%) =
[(L1-L2) / (L1-L0)] × 100
Evaluation criteria ◎: Biofilm removal rate is 80% or more ○: Biofilm removal rate is 60% or more and less than 80% △: Biofilm removal rate is 40% or more and less than 60% ×: Biofilm removal rate is less than 40%

<Evaluation method for the smoothness of teeth>
Using 10 subjects, 1 g of the dentifrice composition was placed on a toothbrush, and the smoothness of the teeth after brushing was determined according to the following criteria. The average value of 10 persons was calculated and evaluated according to the following evaluation criteria.
Here, the sensation of teeth is a sensation of smoothness that can be realized when the tooth surface is sufficiently cleaned by tooth brushing when the tongue is brought into contact with the tooth surface.
Rating criteria 5: Very feel the smoothness of the teeth 4: Feel quite the smoothness of the teeth 3: Slightly feel the smoothness of the teeth 2: Slightly feel the smoothness of the teeth 1: Not feel the smoothness of the teeth Evaluation Standard ◎: Average value is 4.0 points or more and 5.0 points or less ○: Average value is 3.0 points or more and less than 4.0 points Δ: Average value is 2.0 points or more and less than 3.0 points ×: Average value Is less than 2.0

As shown in the comparative examples of Table 3, sodium tetradecene sulfonate alone or granule alone had a low biofilm removal effect on the gap between teeth. Moreover, when an inappropriate granule was combined with sodium tetradecene sulfonate, the biofilm removal effect on the gap between teeth was not improved and was inferior. On the other hand, the dentifrice composition (Example) using the (A) and (B) components of the present invention shown in Tables 1 and 2 together has a biofilm removing effect on the gap between teeth and a smooth feeling of teeth. Is excellent.

Details of the raw materials used are shown below.
(A) sodium tetradecenesulfonate;
Product name K Liporan PJ-400CJ, manufactured by Lion Specialty Chemicals Co., Ltd.
(B) Granule: Tosoh Silica Co., Ltd., trade name NIPGEL,
Average disintegration strength 10-50g / piece Granule B1: AY grade is classified by sieving, average particle size 100μ
collected to m.
Granule B2: AY grade is classified by sieving, average particle size 80 μm
Collected to become.
Granule B3: AY grade is classified by sieving, average particle size 150μ
collected to m.
Granule B4: AY grade is classified by sieving, average particle size 300μ
collected to m.
Granule B5: AY grade is classified by sieving, average particle size 500μ
Collected to be m (comparative product).
Granule B6: AY grade is classified by sieving, average particle size 40 μm
(Comparison product).
Silicic anhydride (abrasive silica); manufactured by Taki Chemical Co., Ltd., average particle size 20 μm

Claims

(A) an α-olefin sulfonate;
(B) A dentifrice composition comprising water-insoluble granules having an average particle size of 50 to 400 μm.
The dentifrice composition according to claim 1, wherein the average particle size of the component (B) is 50 to 250 µm.
The dentifrice composition according to claim 1 or 2, wherein the water-insoluble granules as component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
The dentifrice composition according to claim 3, wherein the water-insoluble granules of component (B) are silica granules having an average particle size of 80 to 150 μm and an average disintegration strength of 10 to 50 g / piece.
The dentifrice composition according to any one of claims 1 to 4, comprising 0.05 to 1.5% by mass of component (A) and 0.1 to 10% by mass of component (B).
The dentifrice composition according to any one of claims 1 to 5, wherein (B) / (A) has a mass ratio of 1 to 60.
The dentifrice composition according to any one of claims 1 to 6, further comprising (C) 0.1 to 5% by mass of a binder.
The dentifrice composition according to claim 7, wherein (C) the binder contains at least xanthan gum.
An oral biofilm remover comprising (A) α-olefin sulfonate and (B) water-insoluble granules having an average particle size of 50 to 400 μm.
The oral biofilm remover according to claim 9, wherein the water-insoluble granules as component (B) are silica granules having an average disintegration strength of 10 to 200 g / piece.
The oral biofilm remover according to claim 9 or 10, wherein (B) / (A) is 1 to 60 in terms of mass ratio.