JP3528389B2 - Oral composition - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition having a high chemical cleaning effect. 2. Description of the Related Art
Stains, plaque, food debris attached to or deposited on the tooth surface,
2. Description of the Related Art Tooth stains such as tobacco tar are removed by a mechanical action of an abrasive compounded in an oral composition such as a toothpaste. [0003] That is, dirt such as food debris adhered to or deposited on the tooth surface is removed by brushing the tooth surface with an oral composition such as toothpaste and a toothbrush. There is also a problem that it is not possible. [0004] For this reason, the following proposals have been made to remove dirt on the tooth surface by a chemical action instead of merely a mechanical action, but the effect is not always sufficient, and the effect of the tooth face is not always sufficient. At present, the removal of dirt largely depends on mechanical action. (1) An oral composition containing a specific organic peroxide (US Pat. No. 3,988,433). (2) An oral composition comprising a combination of a cationic surfactant and malic acid (US Pat. No. 4,183,916). (3) An oral composition containing an ester having an aromatic ring (JP-B-48-43869). (4) An oral composition containing a chelating agent having a stability coefficient of Fe> Ca (Japanese Patent Laid-Open No. 51-139,639). (5) An oral composition using a combination of a polyphosphate and a polyvalent metal cation (JP-A-52-108029). (6) An oral composition using phytic acid and an organic acid in combination (Japanese Patent Application Laid-Open No. 56-18911). (7) tartronic acid, glyceric acid, hydroxy-n-
An oral composition containing butyric acid and dihydroxymalonic acid (JP-A-60-4117). (8) An oral composition comprising a combination of carvone, anethole or 3-octanol and a solvent extract of a plant of the genus Astragalus (JP-A-61-286315). (9) An oral composition containing 2-octanol (JP-A-62-151498). (10) An oral composition containing a specific monoterpene (JP-A-62-181212). (11) An oral composition containing an aliphatic ester having a total of 7 to 11 carbon atoms (JP-A-62-189233). (12) Oral composition containing citric acid, polyphosphoric acid and nonionic surfactant (JP-A-7-126131)
issue). (13) Oral composition containing polyphosphate, orthophosphate and anionic surfactant (Japanese Patent Application No. Hei 7-18483)
No. 8). (14) An oral composition containing a polyphosphate, an orthophosphate and an amphoteric surfactant (Japanese Patent Application No. 7-184839)
issue). [0005] The present invention has been made in view of the above circumstances,
An object of the present invention is to provide an oral composition having a high chemical cleaning effect. Means for Solving the Problems and Embodiments of the Invention The present inventors have made intensive studies to achieve the above object, and as a result, have found that an oral composition comprising a component that does not release calcium ions. And water-soluble pyrophosphate in an amount of 3% by weight or more based on the total weight of the composition.
And (2) M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (where M represents Na or K, and m and n are each an integer of 3 or more. When one or two or more selected from linear and cyclic water-soluble polyphosphates represented by the formula (1) are used in combination at a ratio of 0.2 to 0.9 times the weight of the water-soluble pyrophosphate, the tooth It has been found that the effect of chemically removing dirt on the surface is significantly increased, and stains such as stains, plaques and tobacco tar can be effectively removed by a chemical effect, and the present invention has been accomplished. is there. It is known that a water-soluble pyrophosphate and a water-soluble polyphosphate are blended in an oral composition (JP-A-1-131111, JP-A-2-32010).
JP-A-2-59512, JP-A-5-39213
These proposals relate to the removal of tartar and the stabilization of soluble fluoride ions, and a component which does not release calcium ions at the above-mentioned specific mixing ratio of pyrophosphate and polyphosphate. It has been found for the first time by the present inventors that the effect of chemically removing tooth stains is significantly increased by blending the composition with an oral composition comprising: Hereinafter, the present invention will be described in more detail. As described above, the oral composition of the present invention comprises a water-soluble pyrophosphate and an aqueous polyphosphate in a specific amount and in a specific ratio. Here, as the water-soluble pyrophosphate used in the present invention, tetrasodium pyrophosphate, sodium acid pyrophosphate, potassium pyrophosphate and the like are used. These pyrophosphates are used alone or in combination of two or more. The amount of the pyrophosphate in the oral composition of the present invention is at least 3% by weight, preferably 3 to 10% by weight, particularly 3 to 7% by weight based on the total amount of the composition.
Is preferred. If the compounding amount is less than 3% by weight, even when used in combination with the polyphosphate of the present invention, a sufficient stain cleaning effect cannot be obtained, and the object of the present invention cannot be achieved. If the content exceeds 10% by weight, crystals of pyrophosphate that cannot be completely dissolved may deteriorate the appearance of the composition for oral cavity or may make the feel when used unpleasant. The water-soluble polyphosphate used in the present invention is represented by the following formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K, and n ≧ 3) Such as sodium tripolyphosphate and potassium tripolyphosphate having a polymerization degree of n = 3, sodium tetrapolyphosphate and potassium tetrapolyphosphate having n = 4, and sodium metaphosphate and potassium metaphosphate having a high polymerization degree. Linear polyphosphate, and those represented by the following formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3), that is, the degree of polymerization m Rings such as sodium trimetaphosphate and potassium trimetaphosphate with m = 3, sodium tetrametaphosphate and potassium tetrametaphosphate with m = 4, sodium hexametaphosphate and potassium hexametaphosphate with m = 6 Polyphosphate is used for. These polyphosphates are used alone or in combination of two or more. Among them, linear polyphosphates are preferred. The amount of the above polyphosphate in the oral composition of the present invention is 0.2 to 0.9 of the above pyrophosphate.
Double weight, preferably 0.2 to 0.75 times weight, particularly preferably 0.2 to 0.5 times weight. When the content is 0.
If the weight is less than 2 times or more than 1 time, even if used in combination with the pyrophosphate of the present invention, a sufficient stain cleaning effect cannot be obtained, and the object of the present invention cannot be achieved. The oral composition of the present invention is prepared as dentifrices such as toothpaste, mouthwash, troche, chewing gum and the like.
Where applicable, in this case, the compositions of the present invention are prepared using components that do not release calcium ions in addition to the pyrophosphates and polyphosphates described above. When a component that releases calcium ions, for example, a polishing base such as calcium hydrogen phosphate or calcium carbonate, the released calcium ions inactivate pyrophosphate and polyphosphate and impair their chemical detergency. Therefore, the object of the present invention cannot be achieved. Therefore, the oral composition of the present invention uses an appropriate component according to its type. For example, in the case of toothpaste, an abrasive, a binder, a thickener, a surfactant, A sweetener, a preservative, a fragrance, various active ingredients, and the like can be mixed and manufactured according to a conventional method, but a base or ingredient that releases calcium ions is not used. Specifically, the abrasive includes, for example, crystalline silica, amorphous silica, other silica-based abrasives, aluminosilicate, aluminum oxide, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, Titanium oxide, synthetic resin, etc. are preferably used,
One or more of these abrasives may be blended (the blending amount is usually 3 to 90% by weight). Examples of the binder include carrageenan, sodium carboxymethylcellulose, cellulose derivatives such as methylcellulose, hydroxyethylcellulose and sodium carboxymethylhydroxyethylcellulose.
Alkaline metal alginate such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, gelling properties One or more kinds of inorganic binders such as silica, gelling aluminum silica, veegum, and laponite may be blended (the blending amount is usually 0.5 to 10% by weight). Examples of the thickener include sorbitol, glycerin, ethylene glycol, propylene glycol, 1,
One or more of 3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltitol, lactit and the like may be blended (the blending amount is usually 1 to 50% by weight). Examples of the surfactant include water-soluble salts of higher alkyl sulfates having an alkyl group having 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl monoglyceride sulfonate, coconut monoglyceride sulfonate. Water-soluble salts of higher fatty acid monoglyceride sulfonic acid having 10 to 18 carbon atoms in fatty acid groups such as sodium, olefin sulfonic acid, paraffin sulfonic acid, other anionic activators, stearyl monoglyceride, fatty acid groups such as sucrose mono and dilaurate Has 12 to 1 carbon atoms
8 sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene hydrogenated castor oil, sorbitan monostea to which about 60 mol of ethylene glycol is added Nonionic surfactants such as rate condensates, polymers of ethylene oxide and propylene oxide, and derivatives such as polyoxyethylene polyoxypropylene monolauryl ester, and surfactants such as betaine type and amino acid type amphoteric surfactants are used. Amount usually 0.01 to 7% by weight). Further, as sweeteners, preservatives such as sodium saccharin, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium cyclamate, etc. P-hydroxymethyl benzoic acid, p-hydroxyethyl benzoic acid, p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, sodium benzoate, lower fatty acid monoglyceride, etc. Oils, peppermint oil, sassafras oil, clove oil, eucalyptus oil and the like can be included. In addition, gelatin, peptone, arginine hydrochloride, albumin, whitening agent, silicone, pigment, and other components can be blended. Furthermore, epsilon amine caproic acid, tranexamic acid, dextranase,
Amylase, protease, mutanase, lysozyme,
Lytic enzymes, enzymes such as Litech enzyme, alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, fluorides such as sodium fluoride and ammonium fluoride, chlorhexidine salts, dihydrocholesterol, glycyrrhetin salts, glycyrrhetin One or more active ingredients such as acids, chlorophyll, caropeptides, vitamins, anti-calculus agents, antibacterial agents, anti-plaque agents, hypersensitivity desensitizers such as potassium nitrate, etc. may be blended. Although the pH of the oral composition of the present invention is not particularly limited, it is preferably 6 to 10 from the viewpoint of the stability of pyrophosphate and polyphosphate and the stimulation of oral mucosa, and particularly 6.5 to 9 Is preferred. The oral composition according to the present invention can effectively remove stains on tooth surfaces such as stains, plaques and cigarettes by chemical action, and can clean portions that cannot be reached by a toothbrush. Is also possible, increasing the whitening effect of the tooth surface. Further, since the cleaning effect of the oral composition is extremely high, the amount of the abrasive can be reduced when preparing toothpaste. EXAMPLES Hereinafter, the present invention will be described specifically with reference to Experimental Examples and Examples, but the present invention is not limited to the following Examples. [Experimental Example] A hydroxyapatite disk (HA plate, hereinafter the same, manufactured by Asahi Kogaku Co., Ltd., 7 × 3 mm) was fixed to a mouthpiece, and attached to the mouth (mandibular tongue side).
A pellicle was formed on the A plate. This was placed in a device that alternately dipped in a stain solution and dried in the air, and operated for 24 hours to deposit stain on the surface of the HA plate. The composition of the stain solution is as follows. In addition, all the following% show weight%. Stain solution composition Ferrous chloride n-hydrate 0.05% Instant coffee 0.37% Instant black tea 0.37% The above stained HA plate was immersed in the sample solution shown in Table 1 for 5 minutes, and reciprocating brushing was performed 5 times. After that, the stained pellicle was stained with a 10% phloxine solution to measure the color difference (Lab color system). This removal operation (immersion → brushing → color difference measurement) was repeated until the stain was completely removed (until the color difference of the HA plate became equal to that before the stain was attached). The smaller the number of times of brushing, the higher the chemical removal power. Table 1 shows the results. [Table 1] From the results in Table 1, it was found that the water-soluble pyrophosphate was
It has been found that the chemical cleaning power of stain is specifically enhanced by adding 20 to 100% by weight of a water-soluble polyphosphate to the above-mentioned water-soluble pyrophosphate in a system containing at least% by weight. Hereinafter, examples will be described. [Example 1] Tooth-precipitating silica 30.0% Propylene glycol 3.0 Sorbitol 20.0 Sodium carboxymethyl cellulose 1.4 Saccharin sodium 0.1 Stevioside 0.1 Potassium glycyrrhizinate 1.0 Sodium lauryl sulfate 0.5 N- Sodium lauroyl glutamate 0.5 Tranexamic acid 0.05 α-alumina anhydride 3.0 Colloidal silica 3.0 Methyl paraben 0.05 Fragrance 1.0 Potassium pyrophosphate 5.0 Sodium tripolyphosphate 3.0 Water Balance 100. Example 2 Toothpaste Modified Aluminum Hydroxide 18.0% Propylene Glycol 2.0 Sorbit 20.0 Sodium Hydroxyethyl Cellulose 1.4 Saccharin Sodium 0.1 Sodium Lauryl Sulfate 0.5 Sodium lauryl POE sulfate 0.5 Colloidal silica 3.0 Sodium monofluorophosphate 0.76 Chlorhexidine gluconate 0.1 Methyl paraben 0.05 Fragrance 1.0 Sodium pyrophosphate 3.0 Sodium tetrapolyphosphate 1 0.0 dipotassium hydrogen phosphate 0.5 water balance 100.0% [Example 3] dentifrice silicic acid 30.0% titanium oxide 0.5 sodium carboxymethylcellulose 1.1 carrageenan 0.2 lauryl sulfate Sodium 1.4 Sorbit solution 20.0 Glycerin 20.0 Propylene glycol 3.0 Methyl paraben 0.05 Saccharin sodium 0.15 Fragrance 1.0 Sodium pyrophosphate 4.0 Sodium hexametaphosphate 1.2 Water Residue 100.0% 0030 Example 4] Liquid dentifrice silicic acid anhydride 15.0% 60% sorbite solution 25.0 glycerin 25.0 propylene glycol 5.0 xanthan gum 0.2 sodium N-lauroylglutamate 0.5 sodium lauryl sulfate 0.5 carrageenan 5 Alginic acid 1.0 Sodium fluoride 0.22 Dextranase (1 million U / g) 0.5 Saccharin sodium 0.1 Fragrance 1.0 Sodium pyrophosphate 3.0 Ultra sodium polypolyphosphate 1.2 Water Residue 100. Example 5 Dental Cream Sorbitol 20.0% Propylene Glycol 2.5 Sodium Lauryl Sulfate 1.0 Sodium Carboxymethyl Cellulose 1.0 Sodium Saccharin 0.1 Sodium Paraoxybenzoate 0.1 Fragrance 0 8 Sodium pyrophosphate 3.0 tripolyphosphate 2.0 sodium dihydrogen phosphate 0.5 water remainder Total 100.0% [0032] Example 6 Dental Cream sorbitol 20.0% propylene glycol 3.0 lauryl sulfate Sodium 1.0 Sodium carboxymethylcellulose 2.5 Saccharin sodium 0.1 Ethyl parahydroxybenzoate 0.1 Fragrance 0.8 Sodium pyrophosphate 4.0 Sodium ultrapolyphosphate 0.8 Water Residue 100.0% Example 7] mouthwash ethanol 10.0% sodium saccharin 0.05 sodium monofluorophosphate 0.05 chlorhexidine gluconate 0.01 pigment 0.01 sodium benzoate 0.05 antioxidant 0.01 fragrance 0.3 lauryl Sodium sulfate Potassium 0.3 POE sodium myristyl 0.3 potassium pyrophosphate sulfate 2.5 Sodium tetrapolyphosphate 2.0 water remainder Total 100.0% [0034] Example 8 gargling tablets sodium bicarbonate 55.0% Polyethylene Glycol 400 3.0 Fragrance 1.0 Oleic acid 0.1 Chlorhexidine hydrochloride 0.05 Citric acid 17.0 Sodium pyrophosphate 6.5 Sodium hexametaphosphate 6.5 Water Balance 100.0%

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Isao Minemoto 1-7-7 Honjo, Sumida-ku, Tokyo Inside Rion Co., Ltd. (56) References JP-A-2-59512 (JP, A) JP-A Hei 7-10726 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (1)

(57) [Claim 1] In an oral composition comprising a component that does not release calcium ions, a water-soluble pyrophosphate is incorporated in an amount of 3% by weight or more of the whole composition, and the following general formula ( 1) and (2) M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (where M represents Na or K, and m and n are each an integer of 3 or more.) Wherein at least one of the linear and cyclic water-soluble polyphosphates represented by the formula (1) is mixed 0.2 to 0.9 times the weight of the water-soluble pyrophosphate .
An oral composition having a high chemical cleaning effect on stains .