WO2018151076A1 - Gel-like dentifrice composition and stickiness inhibitor for same - Google Patents
Gel-like dentifrice composition and stickiness inhibitor for same Download PDFInfo
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- WO2018151076A1 WO2018151076A1 PCT/JP2018/004819 JP2018004819W WO2018151076A1 WO 2018151076 A1 WO2018151076 A1 WO 2018151076A1 JP 2018004819 W JP2018004819 W JP 2018004819W WO 2018151076 A1 WO2018151076 A1 WO 2018151076A1
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- stickiness
- gel
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- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to a gel-like dentifrice composition containing no abrasive and excellent in feeling of use, and a stickiness inhibitor used therefor.
- a dentifrice composition usually contains an abrasive for the purpose of removing plaque and the like, but some users prefer a dentifrice that does not contain an abrasive.
- dentifrice containing no abrasive is recommended to prevent adverse effects such as irritation caused by abrasive. Sometimes it is done. For this reason, there is a growing demand for dentifrice compositions such as gels that do not contain abrasives and that are less invasive to the oral mucosa even for high-risk individuals with periodontal disease and that can gently and carefully toothpaste. Yes.
- dentifrice compositions basically contain wetting agents, binders, surfactants, and the like.
- Polyhydric alcohol is blended.
- Dentifrice compositions that do not contain abrasives, especially gel-like dentifrice compositions generally contain a relatively large amount of wetting agent in order to maintain general properties such as shape retention and suppression of liquid separation. Done.
- stickiness is generated due to an increase in the amount of the wetting agent, and the feeling of use tends to deteriorate, and the flavor expression of the fragrance may be lowered, and improvement of the feeling of use has been an issue.
- Patent Documents 1 to 3 Japanese Patent Laid-Open Nos. 2016-102076, 2007-176856, and 2016-40306 contain menthol and other specific fragrances to rinse, refresh, and taste.
- the composition for oral cavity which the etc. improved is proposed.
- the composition for oral cavity of patent document 1 is prepared in the dentifrice gel agent which does not contain an abrasive
- the present invention has been made in view of the above circumstances, and an object thereof is to provide a gel-like dentifrice composition containing no abrasive and having excellent usability, and a tackiness inhibitor used therefor.
- the present inventors have determined that menthol and N-ethyl-p have been added to an abrasive-free gel dentifrice composition containing 40% by mass or more of sorbitol as a wetting agent. It has been found that when blended with a specific ratio of -menthane-3-carboxamide, stickiness due to the wetting agent can be suppressed and an excellent feeling of use can be imparted.
- a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40,
- B) a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40,
- A) The stickiness due to the component is suppressed, the sticky feeling is hardly felt after use, and the refreshing feeling is improved while suppressing the irritation, and the original expression of the flavor of
- the expression of flavor can be further improved by further adding (D) eugenol to the gel dentifrice composition, whereby the flavor can be sufficiently expressed and stickiness can be suppressed. I found it.
- the combination of the fragrances (B) and (C) has a mass ratio of (B) / (C) within a specific range, and is surprisingly unique to the component (A) as a stickiness inhibitor. It was able to give an exceptional effect.
- stickiness may be strongly felt when the amount of wetting agent is increased.
- the sugar alcohol sorbitol which is generally used as a wetting agent, is preferable in that it is less irritating, but it tends to give stickiness depending on the blending amount, and the stickiness may increase as the amount increases.
- the present invention provides the following gel dentifrice composition and its stickiness inhibitor.
- A 40-60 mass% sorbitol, (B) 0.1 to 1% by mass of menthol and (C) 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide
- a gel dentifrice composition containing (B) / (C) in a mass ratio of 0.5 to 40 and containing no abrasive.
- the gel dentifrice composition according to [1] further comprising (D) eugenol in an amount of 0.01 to 0.1% by mass.
- a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive A stickiness inhibitor comprising (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, wherein (B) / (C) has a mass ratio of 0.5 to 40.
- a gel-like dentifrice composition containing no abrasive and excellent in feeling of use and a stickiness inhibitor used therefor.
- This gel dentifrice composition is low in invasiveness to the oral mucosa because it does not contain abrasives, has good general properties such as shape retention, and can be used widely for high-risk people who have developed periodontal disease. It is.
- the gel dentifrice composition of the present invention contains no abrasive, contains (A) 40% by mass or more of sorbitol, and (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide.
- the mass ratio of (B) / (C) is contained within a specific range.
- the gel-like dentifrice composition of the present invention is a dentifrice composition that does not contain an abrasive but has a shape-retaining property that does not drip from the toothbrush when placed on the toothbrush.
- (A) Sorbitol is a wetting agent, and for example, commercially available products such as those manufactured by Mitsubishi Shoji Foodtech Co., Ltd. can be used.
- the blending amount of (A) sorbitol is 40 to 60% (mass%, the same applies hereinafter) of the whole composition, preferably 40 to 50%, particularly from the viewpoint of the shape retention of the preparation and the like. % Is more preferable.
- it is 40% or more, basic physical properties such as shape retention can be sufficiently secured with a composition not containing an abrasive. If it exceeds 60%, the stickiness becomes too strong to be suppressed, and the refreshing feeling is lowered and the flavor expression is also lowered.
- the compounding quantity of (A) component is 42% or more, and also 45% or more, stickiness is fully suppressed and the non-stickiness after use is excellent.
- sugar alcohols and polyhydric alcohols can be blended within a range that does not interfere with the effects of the present invention.
- the blending amount of sugar alcohols other than sorbitol may be 20% or less, particularly 15% or less of the whole composition, or may be unblended (0%).
- Polyhydric alcohol is also used as a solvent, and examples thereof include propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications), ethylene glycol, and the like.
- the blending amount of these polyhydric alcohols is preferably 0 to 10%, particularly 4 to 10% of the whole composition.
- (B) L-menthol is used as the menthol.
- commercially available products such as L-menthol manufactured by Takasago International Corporation can be used.
- menthol-containing essential oils such as peppermint oil and peppermint oil can be used.
- the blending amount of (B) menthol is 0.1 to 1%, preferably 0.2 to 1%, more preferably 0.2 to 0.5% of the whole composition as a pure component. If it is less than 0.1%, stickiness is not sufficiently suppressed, and the feeling of refreshing after use is also inferior. If it exceeds 1%, its own irritation may become too strong to perform sufficient oral cleaning.
- (C) N-ethyl-p-menthane-3-carboxamide a synthetic product can be used, and for example, a commercially available product such as manufactured by Dibodan Japan Co., Ltd. can be used.
- the blending amount of (C) N-ethyl-p-menthane-3-carboxamide is 0.02 to 0.2%, preferably 0.05 to 0.1% of the whole composition. If it is less than 0.02%, the stickiness derived from the component (A) is not sufficiently suppressed, and the refreshing feeling after use may be inferior. If it exceeds 0.2%, flavor expression may be suppressed.
- (B) / (C) indicating the blending ratio of the component (B) to the component (C) is 0.5 to 40, preferably 2 to 10, more preferably 3 to 10 as a mass ratio.
- the stimulation becomes stronger or the flavor expression is suppressed than when the (B) component alone or the (C) component alone is added. Problems such as disappearance or stickiness may not be suppressed, but if it is within the above range, the stickiness derived from the component (A) is sufficiently eliminated, and the stimulus derived from the component (B) is suppressed.
- (D) eugenol when (D) eugenol is further blended with the (C) component, the flavor expression is prevented from being lowered by the (C) component, and the flavor expression is further improved, while sufficiently expressing the flavor, Stickiness can be suppressed.
- eugenol for example, a commercial product such as manufactured by Toyoda Fragrance Co., Ltd. can be used.
- essential oils containing eugenol such as clove oil, cassia oil, pimento oil, bay oil, basil oil, laurel oil, and the like can also be used.
- the blending amount of eugenol is preferably 0.01 to 0.1% of the total composition as a pure component. If it is 0.01% or more, the flavor expression is sufficiently improved. When it is 0.1% or less, irritation and taste (bitterness) by itself can be sufficiently suppressed.
- (D) / (C) indicating the blending ratio of component (D) to component (C) is preferably 0.05 to 5, more preferably 0.1 to 2, as a mass ratio. Within this range, flavor development is further enhanced.
- a fragrance other than these can be added to the composition of the present invention.
- one or more known fragrance materials such as a natural fragrance added as a general oral fragrance, a fragrance obtained by processing a natural fragrance, a simple fragrance, and a blended fragrance can be used.
- the blending amount of such a fragrance is preferably 0.000001 to 2%, particularly 0.00001 to 1% of the whole composition.
- Specific examples of the above-mentioned general flavors for oral use include spearmint oil, anise oil, eucalyptus oil, winter green oil, thyme oil, sage oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, and lime oil. , Lavender oil, rosemary oil, camomil oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute rose, orange flower, etc.
- Fragrances obtained by processing these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), carvone, anethole, cineol, methyl salicylate, 3-l-ment Xipropane-1,2-diol, thymol, linalool, linalyl ace , Limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, Single item flavors such as vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl
- the amount of these components is included in the blending amount of the component (B), (C) or (D) described above. , And can be used within the range of the amount of each component.
- the gel dentifrice composition of the present invention no abrasive is blended, but in addition to the above-described components, other known components can be blended as necessary in a range not impeding the effects of the present invention.
- a binder, a surfactant, a sweetener, an antiseptic, a colorant, various active ingredients, a pH adjuster, and the like can be blended, and these ingredients can be mixed with water to produce by a known method.
- organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, guar gum, gelatin, crystalline cellulose, polyvinyl alcohol, polyvinylpyrrolidone, etc.
- Inorganic binders such as gelling silica, gelling aluminum silica, montmorillonite, kaolin and bentonite can be used, and one or more of these can be used.
- the compounding amount of the binder is usually 0.1 to 13%, particularly 1.1 to 10% of the whole composition.
- the compounding amount of the organic binder is preferably 0.1 to 5% of the whole composition
- the compounding amount of the inorganic binder is preferably 1 to 8%, particularly 1 to 5% of the whole composition.
- the surfactant examples include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.
- Anionic surfactants alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl sulfoacetate, sodium ⁇ -olefin sulfonate nonionic surfactants; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, Polyoxyethylene higher alcohol ether such as polyoxyethylene lauryl ether, sugar fatty acid ester such as sucrose fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant; distearyl chloride Methylammonium, stearyldimethylbenzylammonium chloride amphoteric
- sweetening agent examples include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, and perilartin.
- preservative examples include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
- colorant Blue No. 1, Yellow No. 4, Green No. 3, and the like can be blended in a normal amount.
- active ingredients include known ingredients that are usually blended in dentifrice compositions, such as fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anticalculus agents, anti-plaque agents, and the like of the present invention.
- An effective amount can be blended within a range that does not interfere with the effect.
- fluorides such as sodium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, sodium salt of orthophosphoric acid, tranexamic acid, epsilon aminocaproic acid, tocopherol acetate, ⁇ -bisabolol , Dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetic acid, glycyrrhizic acid or salts thereof, copper compounds such as copper chlorophyllin sodium, chlorophyll, copper gluconate, chelating phosphate compounds such as glycerophosphate, hydroxamic acid or derivatives thereof , Sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, isopropylmethylphenol, benzethonium chloride, cetylpyridinium chloride, allantochlorohydroxyal Chloride, ascorbic acid or
- Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid or salts thereof, phosphoric acid or salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide and potassium hydroxide.
- the water content of the gel dentifrice composition of the present invention is preferably 20 to 60%, more preferably 30 to 50% of the entire composition.
- the stickiness inhibitor of the present invention is (A) a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% sorbitol and not containing an abrasive, comprising (B) menthol and (C ) N-ethyl-p-menthane-3-carboxamide, more preferably (D) eugenol, wherein (B) / (C) has a mass ratio of 0.5 to 40.
- the components (B) and (C), more preferably the component (D) are effective components for suppressing stickiness, and the components (B) and (C) are used in combination at a specific blending ratio (mass ratio).
- these components can be used as stickiness inhibitor composed of only the above-mentioned active ingredient, which is blended into the gel dentifrice composition. Further, these components can be used as stickiness suppressing agents for gel dentifrice compositions by adding these components as active ingredients for stickiness suppression and further adding other components.
- the details of the components (A), (B) and (C), further the component (D), the blending amount and blending ratio thereof, and other components are all the same as the gel dentifrice composition. It is the same.
- Gel dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method.
- sorbitol manufactured by Mitsubishi Corporation Foodtech Co., Ltd.
- menthol manufactured by Takasago International Corporation, L-menthol
- N-ethyl-p-menthane-3-carboxamide Gibodan Japan Co., Ltd., trade name: WS-3
- Eugenol Toyotama Fragrance Co., Ltd.
- the other ingredients were used as standard products for the outer general standards (quasi-drug raw material standards), and the purified water was used as the standard for the cosmetic base (cosmetic raw material standards).
- the perfume A used is a general oral perfume and does not contain menthol, N-ethyl-p-menthane-3-carboxamide and eugenol.
- the composition of perfume A is shown below. Composition of perfume A; Cineol 20 parts by weight Limonene 10 Mentone 20 Carvone 10 Anethol 20 Ethanol 20 Total 100 parts by mass
- Flavor expression 4 points: very good flavor expression 3 points: good flavor expression 2 points: slightly good flavor expression 1 point: poor flavor expression (evaluation criteria) Average score for flavor development ⁇ : 3.5 to 4.0 points ⁇ : 3.0 to less than 3.5 points ⁇ : 2.0 to less than 3.0 points ⁇ : 1.0 to 2 Less than 0 points
- the gel dentifrice compositions (Examples) of the present invention were excellent in non-stickiness, inferior in irritation, refreshing and flavor development.
- the components (B) and / or (C) were absent, the non-stickiness was inferior, and the refreshing feeling and flavor expression were also inferior (Comparative Examples 1 to 3).
- (B) / (C) was too large, even if it contained (B) and (C) component, the non-stickiness was inferior and irritation
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Abstract
A gel-like dentifrice composition which contains 40-60% by mass of (A) sorbitol, 0.1-1% by mass of (B) menthol, and 0.02-0.2% by mass of (C) N-ethyl-p-menthane-3-carboxamide so that the mass ratio (B)/(C) is 0.5 to 40, while containing no polishing agent. This gel-like dentifrice composition which additionally contains 0.01-0.1% by mass of (D) eugenol. A stickiness inhibitor for gel-like dentifrice compositions, which contains the above-described component (A) but does not contain a polishing agent, and which also contains the components (B) and (C), and preferably the component (D) additionally, while having the mass ratio (B)/(C) of 0.5 to 40. Consequently, the present invention is able to provide: a gel-like dentifrice composition which is suppressed in stickiness and has excellent feeling of use, while containing no polishing agent; and a stickiness inhibitor which is used for this gel-like dentifrice composition.
Description
本発明は、べたつきが抑制され、使用感が優れる研磨剤無含有のジェル状歯磨剤組成物及びそれに用いるべたつき抑制剤に関する。
The present invention relates to a gel-like dentifrice composition containing no abrasive and excellent in feeling of use, and a stickiness inhibitor used therefor.
歯磨剤組成物には、通常、歯垢等の除去効果を目的として研磨剤が配合されているが、研磨剤を含有しない歯磨剤を好むユーザーも存在する。また、歯茎が弱っている歯肉炎、歯周炎等の発症者などの歯周病ハイリスク者には、研磨剤による刺激等の悪影響を防止する点から、研磨剤無含有の歯磨剤が推奨されることもある。このため、歯周病ハイリスク者に対しても口腔粘膜への侵襲性が低く、優しくじっくりとハミガキすることができる、研磨剤を含まないジェル状等の歯磨剤組成物への要望が高まっている。
A dentifrice composition usually contains an abrasive for the purpose of removing plaque and the like, but some users prefer a dentifrice that does not contain an abrasive. For those with high risk of periodontal disease such as gingivitis and periodontitis with weak gums, dentifrice containing no abrasive is recommended to prevent adverse effects such as irritation caused by abrasive. Sometimes it is done. For this reason, there is a growing demand for dentifrice compositions such as gels that do not contain abrasives and that are less invasive to the oral mucosa even for high-risk individuals with periodontal disease and that can gently and carefully toothpaste. Yes.
歯磨剤組成物には、研磨剤以外に湿潤剤、粘結剤、界面活性剤等が基本的に配合されており、湿潤剤として乾燥を防いだり外観を良好に保持する目的などで糖アルコールや多価アルコールが配合されている。研磨剤を含まない歯磨剤組成物、特にジェル状の歯磨剤組成物では、保型性、液分離の抑制などの一般特性を保つためにも湿潤剤を比較的多く配合することが一般的に行われる。しかし、研磨剤無含有の組成では、湿潤剤の増量によってべたつきが生じて使用感が悪化し易く、また、香料の香味発現が低下することもあり、使用感の改善が課題となっていた。
In addition to abrasives, dentifrice compositions basically contain wetting agents, binders, surfactants, and the like. For the purpose of preventing drying and maintaining good appearance as wetting agents, Polyhydric alcohol is blended. Dentifrice compositions that do not contain abrasives, especially gel-like dentifrice compositions, generally contain a relatively large amount of wetting agent in order to maintain general properties such as shape retention and suppression of liquid separation. Done. However, in the composition containing no abrasive, stickiness is generated due to an increase in the amount of the wetting agent, and the feeling of use tends to deteriorate, and the flavor expression of the fragrance may be lowered, and improvement of the feeling of use has been an issue.
特許文献１～３（特開２０１６－１０２０７６号公報、特開２００７－１７６８５６号公報、特開２０１６－４０３０６号公報）には、メントールや他の特定香料を配合し、すすぎ性や清涼感、味等が改善した口腔用組成物が提案されている。特許文献１の口腔用組成物は研磨剤無含有の歯磨ゲル剤に調製されるが、使用後のべたつきに関する具体的な検討はされていない。
Patent Documents 1 to 3 (Japanese Patent Laid-Open Nos. 2016-102076, 2007-176856, and 2016-40306) contain menthol and other specific fragrances to rinse, refresh, and taste. The composition for oral cavity which the etc. improved is proposed. Although the composition for oral cavity of patent document 1 is prepared in the dentifrice gel agent which does not contain an abrasive | polishing agent, the specific examination regarding the stickiness after use is not done.
本発明は、上記事情に鑑みなされたもので、べたつきが抑制され、使用感が優れる研磨剤無含有のジェル状歯磨剤組成物及びそれに用いるべたつき抑制剤を提供することを目的とする。
The present invention has been made in view of the above circumstances, and an object thereof is to provide a gel-like dentifrice composition containing no abrasive and having excellent usability, and a tackiness inhibitor used therefor.
本発明者らは、上記目的を達成するため鋭意検討を行った結果、湿潤剤としてソルビトールを４０質量％以上配合した研磨剤無含有のジェル状歯磨剤組成物に、メントールとＮ－エチル－ｐ－メンタン－３－カルボキサミドとを特定割合で組み合わせて配合すると、上記湿潤剤によるべたつきを抑制し、優れた使用感を付与できることを知見した。即ち、本発明では、（Ａ）ソルビトールを４０～６０質量％含有する、研磨剤無含有のジェル状歯磨剤組成物であって、更に、（Ｂ）メントールを０．１～１質量％と（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドを０．０２～０．２質量％とを含有し、（Ｂ）／（Ｃ）が質量比として０．５～４０であることによって、（Ａ）成分によるべたつきが抑制され、使用後にべたつき感がほとんど感じられず、しかも、刺激を抑えつつサッパリ感が向上し、製剤本来の香味の発現性も良好に保持されること、これにより、優れた使用感を与えるジェル状歯磨剤組成物が得られることを見出し、本発明をなすに至った。
また、本発明では、上記ジェル状歯磨剤組成物に、更に（Ｄ）オイゲノールを配合することで、香味の発現性をより改善でき、これにより、香味を十分に発現させてべたつきを抑制できることも見出した。 As a result of intensive studies to achieve the above-mentioned object, the present inventors have determined that menthol and N-ethyl-p have been added to an abrasive-free gel dentifrice composition containing 40% by mass or more of sorbitol as a wetting agent. It has been found that when blended with a specific ratio of -menthane-3-carboxamide, stickiness due to the wetting agent can be suppressed and an excellent feeling of use can be imparted. That is, in the present invention, (A) a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40, A) The stickiness due to the component is suppressed, the sticky feeling is hardly felt after use, and the refreshing feeling is improved while suppressing the irritation, and the original expression of the flavor of the preparation is well maintained. It has been found that a gel-like dentifrice composition that gives a good feeling of use can be obtained, and has led to the present invention.
In the present invention, the expression of flavor can be further improved by further adding (D) eugenol to the gel dentifrice composition, whereby the flavor can be sufficiently expressed and stickiness can be suppressed. I found it.
また、本発明では、上記ジェル状歯磨剤組成物に、更に（Ｄ）オイゲノールを配合することで、香味の発現性をより改善でき、これにより、香味を十分に発現させてべたつきを抑制できることも見出した。 As a result of intensive studies to achieve the above-mentioned object, the present inventors have determined that menthol and N-ethyl-p have been added to an abrasive-free gel dentifrice composition containing 40% by mass or more of sorbitol as a wetting agent. It has been found that when blended with a specific ratio of -menthane-3-carboxamide, stickiness due to the wetting agent can be suppressed and an excellent feeling of use can be imparted. That is, in the present invention, (A) a gel-like dentifrice composition containing 40 to 60% by mass of sorbitol and containing no abrasive, further comprising (B) 0.1 to 1% by mass of menthol ( C) by containing 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide, and (B) / (C) as a mass ratio of 0.5 to 40, A) The stickiness due to the component is suppressed, the sticky feeling is hardly felt after use, and the refreshing feeling is improved while suppressing the irritation, and the original expression of the flavor of the preparation is well maintained. It has been found that a gel-like dentifrice composition that gives a good feeling of use can be obtained, and has led to the present invention.
In the present invention, the expression of flavor can be further improved by further adding (D) eugenol to the gel dentifrice composition, whereby the flavor can be sufficiently expressed and stickiness can be suppressed. I found it.
本発明においては、（Ｂ）及び（Ｃ）成分という香料の組み合わせが、（Ｂ）／（Ｃ）の質量比が特定範囲内で、意外にも、べたつき抑制剤として、（Ａ）成分に特異的に作用し、格別顕著な作用効果を付与できた。この場合、一般的に研磨剤無含有のジェル状歯磨剤組成物では、湿潤剤の配合量を増やすとべたつきが強く感じられるようになることがあった。特に、湿潤剤として汎用的に使用される糖アルコールのソルビトールは、刺激が少ない点で好ましいが、配合量によってべたつきを与え易く、増量するにつれてべたつきが増大するおそれがあった。これに対して、本発明では、後述の実施例にも示すように、研磨剤無含有のジェル状歯磨剤組成物において、（Ａ）成分を４０質量％以上、更に増量して比較的多く配合しても、（Ｂ）及び（Ｃ）成分を特定割合で併用した系を配合すると、使用後にべたつきが抑制されてほとんど感じられることがなく、また、メントールによる刺激が適度に抑えられサッパリ感が向上して満足に感じられ、香味発現性も良好となった。
本発明の作用効果は、（Ｂ）又は（Ｃ）成分を欠くと、これら以外の一般的な口腔用香料が含まれていても劣り、また、（Ｂ）及び（Ｃ）成分を含有していても（Ｂ）／（Ｃ）の質量比が不適切であると劣り、いずれの場合も本発明の目的は達成されなかった。 In the present invention, the combination of the fragrances (B) and (C) has a mass ratio of (B) / (C) within a specific range, and is surprisingly unique to the component (A) as a stickiness inhibitor. It was able to give an exceptional effect. In this case, in general, in gel dentifrice compositions containing no abrasive, stickiness may be strongly felt when the amount of wetting agent is increased. In particular, the sugar alcohol sorbitol, which is generally used as a wetting agent, is preferable in that it is less irritating, but it tends to give stickiness depending on the blending amount, and the stickiness may increase as the amount increases. On the other hand, in this invention, as shown also in the below-mentioned Example, in the gel-like dentifrice composition which does not contain an abrasive | polishing agent, (A) component is 40 mass% or more, further increasing and mix | blending comparatively much However, when a system in which the components (B) and (C) are used together in a specific ratio is mixed, stickiness is suppressed after use and hardly felt, and the stimulation by menthol is moderately suppressed and a refreshing feeling is obtained. It was improved and felt satisfactory, and the flavor development was also good.
The effect of this invention is inferior even if the general fragrance | flavor for oral cavity other than these is contained when (B) or (C) component is missing, and contains (B) and (C) component. However, it is inferior that the mass ratio of (B) / (C) is inappropriate, and in either case, the object of the present invention was not achieved.
本発明の作用効果は、（Ｂ）又は（Ｃ）成分を欠くと、これら以外の一般的な口腔用香料が含まれていても劣り、また、（Ｂ）及び（Ｃ）成分を含有していても（Ｂ）／（Ｃ）の質量比が不適切であると劣り、いずれの場合も本発明の目的は達成されなかった。 In the present invention, the combination of the fragrances (B) and (C) has a mass ratio of (B) / (C) within a specific range, and is surprisingly unique to the component (A) as a stickiness inhibitor. It was able to give an exceptional effect. In this case, in general, in gel dentifrice compositions containing no abrasive, stickiness may be strongly felt when the amount of wetting agent is increased. In particular, the sugar alcohol sorbitol, which is generally used as a wetting agent, is preferable in that it is less irritating, but it tends to give stickiness depending on the blending amount, and the stickiness may increase as the amount increases. On the other hand, in this invention, as shown also in the below-mentioned Example, in the gel-like dentifrice composition which does not contain an abrasive | polishing agent, (A) component is 40 mass% or more, further increasing and mix | blending comparatively much However, when a system in which the components (B) and (C) are used together in a specific ratio is mixed, stickiness is suppressed after use and hardly felt, and the stimulation by menthol is moderately suppressed and a refreshing feeling is obtained. It was improved and felt satisfactory, and the flavor development was also good.
The effect of this invention is inferior even if the general fragrance | flavor for oral cavity other than these is contained when (B) or (C) component is missing, and contains (B) and (C) component. However, it is inferior that the mass ratio of (B) / (C) is inappropriate, and in either case, the object of the present invention was not achieved.
従って、本発明は、下記のジェル状歯磨剤組成物及びそのべたつき抑制剤を提供する。
〔１〕
（Ａ）ソルビトールを４０～６０質量％、
（Ｂ）メントールを０．１～１質量％、及び
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドを０．０２～０．２質量％
含有し、（Ｂ）／（Ｃ）が質量比として０．５～４０であり、研磨剤を含有しないジェル状歯磨剤組成物。
〔２〕
更に、（Ｄ）オイゲノールを０．０１～０．１質量％含有する〔１〕に記載のジェル状歯磨剤組成物。
〔３〕
（Ｄ）／（Ｃ）が質量比として０．０５～５である〔２〕に記載のジェル状歯磨剤組成物。
〔４〕
（Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。
〔５〕
（Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドと、（Ｄ）オイゲノールとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。
〔６〕
（Ｄ）／（Ｃ）が質量比として０．０５～５である〔５〕に記載のべたつき抑制剤。 Accordingly, the present invention provides the following gel dentifrice composition and its stickiness inhibitor.
[1]
(A) 40-60 mass% sorbitol,
(B) 0.1 to 1% by mass of menthol and (C) 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide
A gel dentifrice composition containing (B) / (C) in a mass ratio of 0.5 to 40 and containing no abrasive.
[2]
The gel dentifrice composition according to [1], further comprising (D) eugenol in an amount of 0.01 to 0.1% by mass.
[3]
The gel dentifrice composition according to [2], wherein (D) / (C) is 0.05 to 5 in terms of mass ratio.
[4]
(A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
A stickiness inhibitor comprising (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, wherein (B) / (C) has a mass ratio of 0.5 to 40.
[5]
(A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
(B) Menthol, (C) N-ethyl-p-menthane-3-carboxamide, and (D) eugenol, (B) / (C) having a mass ratio of 0.5-40 Agent.
[6]
The tackiness inhibitor as described in [5], wherein (D) / (C) is 0.05 to 5 as a mass ratio.
〔１〕
（Ａ）ソルビトールを４０～６０質量％、
（Ｂ）メントールを０．１～１質量％、及び
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドを０．０２～０．２質量％
含有し、（Ｂ）／（Ｃ）が質量比として０．５～４０であり、研磨剤を含有しないジェル状歯磨剤組成物。
〔２〕
更に、（Ｄ）オイゲノールを０．０１～０．１質量％含有する〔１〕に記載のジェル状歯磨剤組成物。
〔３〕
（Ｄ）／（Ｃ）が質量比として０．０５～５である〔２〕に記載のジェル状歯磨剤組成物。
〔４〕
（Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。
〔５〕
（Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドと、（Ｄ）オイゲノールとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。
〔６〕
（Ｄ）／（Ｃ）が質量比として０．０５～５である〔５〕に記載のべたつき抑制剤。 Accordingly, the present invention provides the following gel dentifrice composition and its stickiness inhibitor.
[1]
(A) 40-60 mass% sorbitol,
(B) 0.1 to 1% by mass of menthol and (C) 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide
A gel dentifrice composition containing (B) / (C) in a mass ratio of 0.5 to 40 and containing no abrasive.
[2]
The gel dentifrice composition according to [1], further comprising (D) eugenol in an amount of 0.01 to 0.1% by mass.
[3]
The gel dentifrice composition according to [2], wherein (D) / (C) is 0.05 to 5 in terms of mass ratio.
[4]
(A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
A stickiness inhibitor comprising (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, wherein (B) / (C) has a mass ratio of 0.5 to 40.
[5]
(A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
(B) Menthol, (C) N-ethyl-p-menthane-3-carboxamide, and (D) eugenol, (B) / (C) having a mass ratio of 0.5-40 Agent.
[6]
The tackiness inhibitor as described in [5], wherein (D) / (C) is 0.05 to 5 as a mass ratio.
本発明によれば、べたつきが抑制され、使用感が優れる研磨剤無含有のジェル状歯磨剤組成物及びそれに用いるべたつき抑制剤を提供できる。このジェル状歯磨剤組成物は、研磨剤を含まないことから口腔粘膜への侵襲性が低く、保型性等の一般特性も良く、歯周病を発症したハイリスク者用としても幅広く使用可能である。
According to the present invention, it is possible to provide a gel-like dentifrice composition containing no abrasive and excellent in feeling of use and a stickiness inhibitor used therefor. This gel dentifrice composition is low in invasiveness to the oral mucosa because it does not contain abrasives, has good general properties such as shape retention, and can be used widely for high-risk people who have developed periodontal disease. It is.
以下、本発明につき更に詳述する。本発明のジェル状歯磨剤組成物は、研磨剤無含有であり、（Ａ）ソルビトールを４０質量％以上含有し、かつ（Ｂ）メントールと（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドとを、（Ｂ）／（Ｃ）の質量比が特定範囲内で含有することを特徴とする。
ここで、本発明のジェル状歯磨剤組成物は、研磨剤が無含有であるが、歯ブラシに載せた際に歯ブラシから垂れない保型性を有する歯磨剤組成物である。 The present invention will be described in further detail below. The gel dentifrice composition of the present invention contains no abrasive, contains (A) 40% by mass or more of sorbitol, and (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide. The mass ratio of (B) / (C) is contained within a specific range.
Here, the gel-like dentifrice composition of the present invention is a dentifrice composition that does not contain an abrasive but has a shape-retaining property that does not drip from the toothbrush when placed on the toothbrush.
ここで、本発明のジェル状歯磨剤組成物は、研磨剤が無含有であるが、歯ブラシに載せた際に歯ブラシから垂れない保型性を有する歯磨剤組成物である。 The present invention will be described in further detail below. The gel dentifrice composition of the present invention contains no abrasive, contains (A) 40% by mass or more of sorbitol, and (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide. The mass ratio of (B) / (C) is contained within a specific range.
Here, the gel-like dentifrice composition of the present invention is a dentifrice composition that does not contain an abrasive but has a shape-retaining property that does not drip from the toothbrush when placed on the toothbrush.
（Ａ）ソルビトールは、湿潤剤であり、例えば、三菱商事フードテック（株）製等の市販品を使用できる。
（Ａ）ソルビトールの配合量は、組成物全体の４０～６０％（質量％、以下同様）であり、好ましくは４０～５０％であり、特に製剤の保型性等の点から、４２～５０％がより好ましい。４０％以上であると、研磨剤を含まない組成で保型性等の基本物性を十分に確保できる。６０％を超えると、べたつきが強くなりすぎて抑えきれなくなり、また、サッパリ感が低下し、香味発現性も低下する。
なお、本発明では、（Ａ）成分の配合量が４２％以上、更には４５％以上であっても、べたつきが十分に抑制され、使用後のべたつきのなさが優れる。 (A) Sorbitol is a wetting agent, and for example, commercially available products such as those manufactured by Mitsubishi Shoji Foodtech Co., Ltd. can be used.
The blending amount of (A) sorbitol is 40 to 60% (mass%, the same applies hereinafter) of the whole composition, preferably 40 to 50%, particularly from the viewpoint of the shape retention of the preparation and the like. % Is more preferable. When it is 40% or more, basic physical properties such as shape retention can be sufficiently secured with a composition not containing an abrasive. If it exceeds 60%, the stickiness becomes too strong to be suppressed, and the refreshing feeling is lowered and the flavor expression is also lowered.
In addition, in this invention, even if the compounding quantity of (A) component is 42% or more, and also 45% or more, stickiness is fully suppressed and the non-stickiness after use is excellent.
（Ａ）ソルビトールの配合量は、組成物全体の４０～６０％（質量％、以下同様）であり、好ましくは４０～５０％であり、特に製剤の保型性等の点から、４２～５０％がより好ましい。４０％以上であると、研磨剤を含まない組成で保型性等の基本物性を十分に確保できる。６０％を超えると、べたつきが強くなりすぎて抑えきれなくなり、また、サッパリ感が低下し、香味発現性も低下する。
なお、本発明では、（Ａ）成分の配合量が４２％以上、更には４５％以上であっても、べたつきが十分に抑制され、使用後のべたつきのなさが優れる。 (A) Sorbitol is a wetting agent, and for example, commercially available products such as those manufactured by Mitsubishi Shoji Foodtech Co., Ltd. can be used.
The blending amount of (A) sorbitol is 40 to 60% (mass%, the same applies hereinafter) of the whole composition, preferably 40 to 50%, particularly from the viewpoint of the shape retention of the preparation and the like. % Is more preferable. When it is 40% or more, basic physical properties such as shape retention can be sufficiently secured with a composition not containing an abrasive. If it exceeds 60%, the stickiness becomes too strong to be suppressed, and the refreshing feeling is lowered and the flavor expression is also lowered.
In addition, in this invention, even if the compounding quantity of (A) component is 42% or more, and also 45% or more, stickiness is fully suppressed and the non-stickiness after use is excellent.
本発明では、湿潤剤として、（Ａ）ソルビトール以外にその他の糖アルコールや多価アルコールを本発明の効果を妨げない範囲で配合できる。なお、特にソルビトール以外の糖アルコールの配合量は、組成物全体の２０％以下、特に１５％以下でもよく、無配合（０％）でもよい。
また、多価アルコールは、溶剤としても用いられ、例えばプロピレングリコール、平均分子量２００～６，０００（医薬部外品原料規格記載の平均分子量）のポリエチレングリコール、エチレングリコール等が挙げられる。これら多価アルコールの配合量は、組成物全体の０～１０％、特に４～１０％が好ましい。 In the present invention, as a wetting agent, in addition to (A) sorbitol, other sugar alcohols and polyhydric alcohols can be blended within a range that does not interfere with the effects of the present invention. In particular, the blending amount of sugar alcohols other than sorbitol may be 20% or less, particularly 15% or less of the whole composition, or may be unblended (0%).
Polyhydric alcohol is also used as a solvent, and examples thereof include propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications), ethylene glycol, and the like. The blending amount of these polyhydric alcohols is preferably 0 to 10%, particularly 4 to 10% of the whole composition.
また、多価アルコールは、溶剤としても用いられ、例えばプロピレングリコール、平均分子量２００～６，０００（医薬部外品原料規格記載の平均分子量）のポリエチレングリコール、エチレングリコール等が挙げられる。これら多価アルコールの配合量は、組成物全体の０～１０％、特に４～１０％が好ましい。 In the present invention, as a wetting agent, in addition to (A) sorbitol, other sugar alcohols and polyhydric alcohols can be blended within a range that does not interfere with the effects of the present invention. In particular, the blending amount of sugar alcohols other than sorbitol may be 20% or less, particularly 15% or less of the whole composition, or may be unblended (0%).
Polyhydric alcohol is also used as a solvent, and examples thereof include propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications), ethylene glycol, and the like. The blending amount of these polyhydric alcohols is preferably 0 to 10%, particularly 4 to 10% of the whole composition.
本発明では、（Ｂ）メントールと（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドとを組み合わせることによって、これらがべたつき抑制剤として、（Ａ）成分に特異的に作用する。（Ｂ）又は（Ｃ）成分を欠くと、べたつきが抑制されない。また、使用後のサッパリ感が劣り、香味発現性も劣る。
In the present invention, by combining (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, these act specifically on the component (A) as stickiness inhibitors. If the component (B) or (C) is absent, stickiness is not suppressed. Moreover, the feeling of refreshing after use is inferior and flavor expression is also inferior.
（Ｂ）メントールは、Ｌ－メントールが用いられ、例えば高砂香料工業（株）製のＬ－メントール等の市販品を使用できる。また、メントールを含む精油、例えばペパーミント油、ハッカ油等を使用することもできる。
（Ｂ）メントールの配合量は、純分として組成物全体の０．１～１％であり、好ましくは０．２～１％、より好ましくは０．２～０．５％である。０．１％未満であると、べたつきが十分に抑制されず、使用後のサッパリ感も劣る。１％を超えると、それ自身の刺激が強くなり過ぎて十分な口腔清掃ができないことがある。 (B) L-menthol is used as the menthol. For example, commercially available products such as L-menthol manufactured by Takasago International Corporation can be used. Also, menthol-containing essential oils such as peppermint oil and peppermint oil can be used.
The blending amount of (B) menthol is 0.1 to 1%, preferably 0.2 to 1%, more preferably 0.2 to 0.5% of the whole composition as a pure component. If it is less than 0.1%, stickiness is not sufficiently suppressed, and the feeling of refreshing after use is also inferior. If it exceeds 1%, its own irritation may become too strong to perform sufficient oral cleaning.
（Ｂ）メントールの配合量は、純分として組成物全体の０．１～１％であり、好ましくは０．２～１％、より好ましくは０．２～０．５％である。０．１％未満であると、べたつきが十分に抑制されず、使用後のサッパリ感も劣る。１％を超えると、それ自身の刺激が強くなり過ぎて十分な口腔清掃ができないことがある。 (B) L-menthol is used as the menthol. For example, commercially available products such as L-menthol manufactured by Takasago International Corporation can be used. Also, menthol-containing essential oils such as peppermint oil and peppermint oil can be used.
The blending amount of (B) menthol is 0.1 to 1%, preferably 0.2 to 1%, more preferably 0.2 to 0.5% of the whole composition as a pure component. If it is less than 0.1%, stickiness is not sufficiently suppressed, and the feeling of refreshing after use is also inferior. If it exceeds 1%, its own irritation may become too strong to perform sufficient oral cleaning.
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドは、合成品を用いることができ、例えばジボダンジャパン（株）製等の市販品を使用できる。
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドの配合量は、組成物全体の０．０２～０．２％であり、好ましくは０．０５～０．１％である。０．０２％に満たないと、（Ａ）成分由来のべたつきが十分に抑制されず、使用後のサッパリ感が劣ることもある。０．２％を超えると、香味発現を抑えてしまうことがある。 As (C) N-ethyl-p-menthane-3-carboxamide, a synthetic product can be used, and for example, a commercially available product such as manufactured by Dibodan Japan Co., Ltd. can be used.
The blending amount of (C) N-ethyl-p-menthane-3-carboxamide is 0.02 to 0.2%, preferably 0.05 to 0.1% of the whole composition. If it is less than 0.02%, the stickiness derived from the component (A) is not sufficiently suppressed, and the refreshing feeling after use may be inferior. If it exceeds 0.2%, flavor expression may be suppressed.
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドの配合量は、組成物全体の０．０２～０．２％であり、好ましくは０．０５～０．１％である。０．０２％に満たないと、（Ａ）成分由来のべたつきが十分に抑制されず、使用後のサッパリ感が劣ることもある。０．２％を超えると、香味発現を抑えてしまうことがある。 As (C) N-ethyl-p-menthane-3-carboxamide, a synthetic product can be used, and for example, a commercially available product such as manufactured by Dibodan Japan Co., Ltd. can be used.
The blending amount of (C) N-ethyl-p-menthane-3-carboxamide is 0.02 to 0.2%, preferably 0.05 to 0.1% of the whole composition. If it is less than 0.02%, the stickiness derived from the component (A) is not sufficiently suppressed, and the refreshing feeling after use may be inferior. If it exceeds 0.2%, flavor expression may be suppressed.
更に、（Ｃ）成分に対する（Ｂ）成分の配合割合を示す（Ｂ）／（Ｃ）は、質量比として０．５～４０であり、好ましくは２～１０、より好ましくは３～１０である。（Ｂ）成分と（Ｃ）成分とを不適切な割合で併用すると、（Ｂ）成分単独もしくは（Ｃ）成分単独で配合する場合よりも刺激が強くなったり、香味発現が抑えられて改善しなくなるなどの使用感の問題が生じたり、べたつきが抑制されないことがあるが、上記範囲内であると、（Ａ）成分由来のべたつきが十分に解消し、かつ、（Ｂ）成分由来の刺激を抑えつつ使用後にサッパリした使用感を満足に付与でき、香味発現性も良好となり、飛躍的に使用感が改善する。（Ｂ）／（Ｃ）が０．５未満であると、使用後のサッパリ感が劣ったり、香味発現が抑えられてしまう。４０を超えると、べたつきが改善されず、また、刺激が強まってしまう。
Further, (B) / (C) indicating the blending ratio of the component (B) to the component (C) is 0.5 to 40, preferably 2 to 10, more preferably 3 to 10 as a mass ratio. . When the (B) component and the (C) component are used in an inappropriate ratio, the stimulation becomes stronger or the flavor expression is suppressed than when the (B) component alone or the (C) component alone is added. Problems such as disappearance or stickiness may not be suppressed, but if it is within the above range, the stickiness derived from the component (A) is sufficiently eliminated, and the stimulus derived from the component (B) is suppressed. It is possible to satisfactorily give a feeling of use after use while suppressing it, to improve the flavor expression, and to dramatically improve the feeling of use. When (B) / (C) is less than 0.5, the feeling of refreshing after use is inferior or the expression of flavor is suppressed. If it exceeds 40, stickiness will not be improved and stimulation will increase.
本発明では、更に、（Ｃ）成分と共に（Ｄ）オイゲノールを配合すると、（Ｃ）成分によって香味発現性が低下するのを防止して香味発現性をより向上し、十分に香味発現させつつ、べたつきを抑制できる。
（Ｄ）オイゲノールは、例えば豊玉香料（株）製等の市販品を使用できる。また、オイゲノールを含む精油、例えばクローブ油、カシア油、ピメント油、ベイ油、バジル油、ローレル油等を用いることもできる。 In the present invention, when (D) eugenol is further blended with the (C) component, the flavor expression is prevented from being lowered by the (C) component, and the flavor expression is further improved, while sufficiently expressing the flavor, Stickiness can be suppressed.
(D) As eugenol, for example, a commercial product such as manufactured by Toyoda Fragrance Co., Ltd. can be used. In addition, essential oils containing eugenol, such as clove oil, cassia oil, pimento oil, bay oil, basil oil, laurel oil, and the like can also be used.
（Ｄ）オイゲノールは、例えば豊玉香料（株）製等の市販品を使用できる。また、オイゲノールを含む精油、例えばクローブ油、カシア油、ピメント油、ベイ油、バジル油、ローレル油等を用いることもできる。 In the present invention, when (D) eugenol is further blended with the (C) component, the flavor expression is prevented from being lowered by the (C) component, and the flavor expression is further improved, while sufficiently expressing the flavor, Stickiness can be suppressed.
(D) As eugenol, for example, a commercial product such as manufactured by Toyoda Fragrance Co., Ltd. can be used. In addition, essential oils containing eugenol, such as clove oil, cassia oil, pimento oil, bay oil, basil oil, laurel oil, and the like can also be used.
（Ｄ）オイゲノールの配合量は、純分として組成物全体の０．０１～０．１％が望ましい。０．０１％以上であると、香味発現性が十分に向上する。０．１％以下であると、それ自身による刺激や嫌味（苦味）が十分に抑えられる。
(D) The blending amount of eugenol is preferably 0.01 to 0.1% of the total composition as a pure component. If it is 0.01% or more, the flavor expression is sufficiently improved. When it is 0.1% or less, irritation and taste (bitterness) by itself can be sufficiently suppressed.
更に、（Ｃ）成分に対する（Ｄ）成分の配合割合を示す（Ｄ）／（Ｃ）は、質量比として０．０５～５が好ましく、より好ましくは０．１～２である。この範囲内であると、香味発現性がより高まる。
Furthermore, (D) / (C) indicating the blending ratio of component (D) to component (C) is preferably 0.05 to 5, more preferably 0.1 to 2, as a mass ratio. Within this range, flavor development is further enhanced.
なお、本発明組成物には、（Ｂ）及び（Ｃ）成分、更には（Ｄ）成分に加えて、これら以外の香料を配合できる。具体的には、一般的な口腔用香料として添加される天然香料、天然香料を加工処理した香料、単体香料、調合香料などの公知の香料素材を１種又は２種以上使用できる。このような香料の配合量は、組成物全体の０．０００００１～２％、特に０．００００１～１％が好ましい。
In addition, in addition to the components (B) and (C), and further the component (D), a fragrance other than these can be added to the composition of the present invention. Specifically, one or more known fragrance materials such as a natural fragrance added as a general oral fragrance, a fragrance obtained by processing a natural fragrance, a simple fragrance, and a blended fragrance can be used. The blending amount of such a fragrance is preferably 0.000001 to 2%, particularly 0.00001 to 1% of the whole composition.
上記の一般的な口腔用香料として具体的には、スペアミント油、アニス油、ユーカリ油、ウィンターグリーン油、タイム油、セージ油、レモン油、オレンジ油、カルダモン油、コリアンダー油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、カモミル油、キャラウェイ油、マジョラム油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、イリスコンクリート、アブソリュートローズ、オレンジフラワー等の天然香料、これら天然香料を加工処理（前溜部カット、後溜部カット、分留、液液抽出、エッセンス化、粉末香料化等）した香料、カルボン、アネトール、シネオール、サリチル酸メチル、３－ｌ－メントキシプロパン－１，２－ジオール、チモール、リナロール、リナリールアセテート、リモネン、メントン、メンチルアセテート、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビルアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、バニリン、ウンデカラクトン、ヘキサナール、プロピルアルコール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルファイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、メチルラクテート、エチルチオアセテート等の単品香料、更に、ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、バターフレーバー、ミルクフレーバー、フルーツミックスフレーバー、トロピカルフルーツフレーバー等の調合香料が挙げられる。
なお、（Ｂ）、（Ｃ）又は（Ｄ）成分が香料中に含まれる場合は、これら成分の量を上述した（Ｂ）、（Ｃ）又は（Ｄ）成分の配合量に含めて計算し、それぞれの成分の配合量の範囲内で使用し得る。 Specific examples of the above-mentioned general flavors for oral use include spearmint oil, anise oil, eucalyptus oil, winter green oil, thyme oil, sage oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, and lime oil. , Lavender oil, rosemary oil, camomil oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute rose, orange flower, etc. , Fragrances obtained by processing these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), carvone, anethole, cineol, methyl salicylate, 3-l-ment Xipropane-1,2-diol, thymol, linalool, linalyl ace , Limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, Single item flavors such as vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate, strawberry flavor, apple flavor, Banana Flavor, Pineapple Flavor, Grape Flavor, Mango Flavor, Butter Flavor, Mi Click flavor, fruit mix flavors, include the blended fragrance such as tropical fruit flavors.
In addition, when the component (B), (C) or (D) is contained in the fragrance, the amount of these components is included in the blending amount of the component (B), (C) or (D) described above. , And can be used within the range of the amount of each component.
なお、（Ｂ）、（Ｃ）又は（Ｄ）成分が香料中に含まれる場合は、これら成分の量を上述した（Ｂ）、（Ｃ）又は（Ｄ）成分の配合量に含めて計算し、それぞれの成分の配合量の範囲内で使用し得る。 Specific examples of the above-mentioned general flavors for oral use include spearmint oil, anise oil, eucalyptus oil, winter green oil, thyme oil, sage oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, and lime oil. , Lavender oil, rosemary oil, camomil oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute rose, orange flower, etc. , Fragrances obtained by processing these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), carvone, anethole, cineol, methyl salicylate, 3-l-ment Xipropane-1,2-diol, thymol, linalool, linalyl ace , Limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, Single item flavors such as vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate, strawberry flavor, apple flavor, Banana Flavor, Pineapple Flavor, Grape Flavor, Mango Flavor, Butter Flavor, Mi Click flavor, fruit mix flavors, include the blended fragrance such as tropical fruit flavors.
In addition, when the component (B), (C) or (D) is contained in the fragrance, the amount of these components is included in the blending amount of the component (B), (C) or (D) described above. , And can be used within the range of the amount of each component.
本発明のジェル状歯磨剤組成物は、研磨剤が配合されないが、上記成分に加えて、必要に応じて本発明の効果を妨げない範囲で他の公知成分を配合することができる。例えば、粘結剤、界面活性剤、甘味剤、防腐剤、着色剤、各種有効成分、ｐＨ調整剤等を配合し、これら成分と水とを混合して公知の方法で製造することができる。
In the gel dentifrice composition of the present invention, no abrasive is blended, but in addition to the above-described components, other known components can be blended as necessary in a range not impeding the effects of the present invention. For example, a binder, a surfactant, a sweetener, an antiseptic, a colorant, various active ingredients, a pH adjuster, and the like can be blended, and these ingredients can be mixed with water to produce by a known method.
粘結剤としては、ポリアクリル酸ナトリウム、キサンタンガム、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル、カルボキシメチルセルロースナトリウム、ヒドロキシエチルセルロース、カルボキシビニルポリマー、グアガム、ゼラチン、結晶セルロース、ポリビニルアルコール、ポリビニルピロリドン等の有機粘結剤、ゲル化性シリカ、ゲル化性アルミニウムシリカ、モンモリロナイト、カオリン、ベントナイト等の無機粘結剤が挙げられ、これらの１種又は２種以上を使用できる。粘結剤の配合量は、通常、組成物全体の０．１～１３％、特に１．１～１０％である。特に、有機粘結剤の配合量は、組成物全体の０．１～５％が好ましく、無機粘結剤の配合量は、組成物全体の１～８％、特に１～５％が好ましい。
As the binder, organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, guar gum, gelatin, crystalline cellulose, polyvinyl alcohol, polyvinylpyrrolidone, etc. Inorganic binders such as gelling silica, gelling aluminum silica, montmorillonite, kaolin and bentonite can be used, and one or more of these can be used. The compounding amount of the binder is usually 0.1 to 13%, particularly 1.1 to 10% of the whole composition. In particular, the compounding amount of the organic binder is preferably 0.1 to 5% of the whole composition, and the compounding amount of the inorganic binder is preferably 1 to 8%, particularly 1 to 5% of the whole composition.
界面活性剤としては、アニオン性界面活性剤、ノニオン性界面活性剤、カチオン性界面活性剤、両イオン性界面活性剤が挙げられる。具体的には下記に示すものを使用できる。
アニオン性界面活性剤；ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム等のアルキル硫酸塩、ラウリルスルホ酢酸ナトリウム、α－オレフィンスルホン酸ナトリウム
ノニオン性界面活性剤；ポリオキシエチレン硬化ヒマシ油等のポリオキシエチレン脂肪酸エステル、ポリオキシエチレンラウリルエーテル等のポリオキシエチレン高級アルコールエーテル、ショ糖脂肪酸エステル等の糖脂肪酸エステル、糖アルコール脂肪酸エステル、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル
カチオン性界面活性剤；塩化ジステアリルメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム
両イオン性界面活性剤；２－アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタイン等のベタイン系
界面活性剤の配合量は、通常、組成物全体の０．６～７％、特に１．１～５％である。また、アニオン性界面活性剤、特にラウリル硫酸ナトリウム等のアルキル硫酸塩の配合量は、組成物全体の０．１～３％、特に０．２～２％が好ましい。 Examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant. Specifically, the following can be used.
Anionic surfactants; alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate nonionic surfactants; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, Polyoxyethylene higher alcohol ether such as polyoxyethylene lauryl ether, sugar fatty acid ester such as sucrose fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant; distearyl chloride Methylammonium, stearyldimethylbenzylammonium chloride amphoteric surfactants; 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolini The amount of betaine surfactants such as Mubetain is usually 0.6 to 7% of the total composition, in particular from 1.1 to 5%. The blending amount of the anionic surfactant, particularly alkyl sulfate such as sodium lauryl sulfate is preferably 0.1 to 3%, particularly preferably 0.2 to 2% of the whole composition.
アニオン性界面活性剤；ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム等のアルキル硫酸塩、ラウリルスルホ酢酸ナトリウム、α－オレフィンスルホン酸ナトリウム
ノニオン性界面活性剤；ポリオキシエチレン硬化ヒマシ油等のポリオキシエチレン脂肪酸エステル、ポリオキシエチレンラウリルエーテル等のポリオキシエチレン高級アルコールエーテル、ショ糖脂肪酸エステル等の糖脂肪酸エステル、糖アルコール脂肪酸エステル、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル
カチオン性界面活性剤；塩化ジステアリルメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム
両イオン性界面活性剤；２－アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタイン等のベタイン系
界面活性剤の配合量は、通常、組成物全体の０．６～７％、特に１．１～５％である。また、アニオン性界面活性剤、特にラウリル硫酸ナトリウム等のアルキル硫酸塩の配合量は、組成物全体の０．１～３％、特に０．２～２％が好ましい。 Examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant. Specifically, the following can be used.
Anionic surfactants; alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate nonionic surfactants; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, Polyoxyethylene higher alcohol ether such as polyoxyethylene lauryl ether, sugar fatty acid ester such as sucrose fatty acid ester, sugar alcohol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant; distearyl chloride Methylammonium, stearyldimethylbenzylammonium chloride amphoteric surfactants; 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolini The amount of betaine surfactants such as Mubetain is usually 0.6 to 7% of the total composition, in particular from 1.1 to 5%. The blending amount of the anionic surfactant, particularly alkyl sulfate such as sodium lauryl sulfate is preferably 0.1 to 3%, particularly preferably 0.2 to 2% of the whole composition.
甘味剤としては、サッカリンナトリウム、アスパルテーム、ステビオサイド、ステビアエキス、ネオヘスペリジルジヒドロカルコン、ペリラルチン等が挙げられる。
防腐剤としては、ブチルパラベン、エチルパラベン等のパラオキシ安息香酸エステル、安息香酸ナトリウム等の安息香酸又はその塩などが挙げられる。
着色剤としては、青色１号、黄色４号、緑色３号等を通常量で配合することができる。 Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, and perilartin.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, and the like can be blended in a normal amount.
防腐剤としては、ブチルパラベン、エチルパラベン等のパラオキシ安息香酸エステル、安息香酸ナトリウム等の安息香酸又はその塩などが挙げられる。
着色剤としては、青色１号、黄色４号、緑色３号等を通常量で配合することができる。 Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, and perilartin.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, and the like can be blended in a normal amount.
有効成分としては、歯磨剤組成物に通常、配合される公知のもの、例えばフッ化物、殺菌剤、抗炎症剤、酵素、植物抽出物、歯石防止剤、歯垢防止剤などを、本発明の効果を妨げない範囲で有効量を配合できる。具体的には、フッ化ナトリウム、フッ化第１錫、フッ化ストロンチウム、モノフルオロリン酸ナトリウム等のフッ化物、正リン酸のナトリウム塩、トラネキサム酸、イプシロンアミノカプロン酸、トコフェロール酢酸エステル、α－ビサボロール、ジヒドロコレステロール、クロロヘキシジン塩類、アズレン、グリチルレチン、グリチルレチン酸、グリチルリチン酸又はその塩類や、銅クロロフィリンナトリウム、クロロフィル、グルコン酸銅等の銅化合物、グリセロホスフェート等のキレート性リン酸化合物、ヒドロキサム酸又はその誘導体、トリポリリン酸ナトリウム、メトキシエチレン、エピジヒドロコレステリン、イソプロピルメチルフェノール、塩化ベンゼトニウム、塩化セチルピリジニウム、アラントインクロルヒドロキシアルミニウム、アスコルビン酸又はその塩、アスコルビン酸リン酸エステル又はその塩、塩化リゾチーム、トリクロロカルバニリド、クエン酸亜鉛、オウバクエキスなどが挙げられる。これらのうち、効果の点で、トコフェロール酢酸エステル、イソプロピルメチルフェノールが好ましく、その配合量は有効量でよいが、組成物全体の０．０１～２％、特に０．０５～１％が好ましい。
Examples of active ingredients include known ingredients that are usually blended in dentifrice compositions, such as fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anticalculus agents, anti-plaque agents, and the like of the present invention. An effective amount can be blended within a range that does not interfere with the effect. Specifically, fluorides such as sodium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, sodium salt of orthophosphoric acid, tranexamic acid, epsilon aminocaproic acid, tocopherol acetate, α-bisabolol , Dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetic acid, glycyrrhizic acid or salts thereof, copper compounds such as copper chlorophyllin sodium, chlorophyll, copper gluconate, chelating phosphate compounds such as glycerophosphate, hydroxamic acid or derivatives thereof , Sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, isopropylmethylphenol, benzethonium chloride, cetylpyridinium chloride, allantochlorohydroxyal Chloride, ascorbic acid or a salt thereof, ascorbic acid phosphoric acid ester or its salt, lysozyme chloride, trichlorocarbanilide, zinc citrate, and the like bark extract. Of these, tocopherol acetate and isopropylmethylphenol are preferable from the viewpoint of effects, and the compounding amount may be an effective amount, but is preferably 0.01 to 2%, particularly 0.05 to 1% of the total composition.
ｐＨ調整剤としては、クエン酸、乳酸、リンゴ酸等の有機酸又はその塩類、リン酸又はその塩類、塩酸、水酸化ナトリウム、水酸化カリウム等の無機化合物が挙げられる。
Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid or salts thereof, phosphoric acid or salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide and potassium hydroxide.
本発明のジェル状歯磨剤組成物の水分量は、組成物全体の２０～６０％が好ましく、３０～５０％がより好ましい。
The water content of the gel dentifrice composition of the present invention is preferably 20 to 60%, more preferably 30 to 50% of the entire composition.
また、本発明のべたつき抑制剤は、（Ａ）ソルビトールを４０～６０％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド、更に好ましくは（Ｄ）オイゲノールとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であることを特徴とする。
ここで、（Ｂ）及び（Ｃ）成分、更に好ましくは（Ｄ）成分が、べたつき抑制の有効成分であり、（Ｂ）及び（Ｃ）成分は特定の配合割合（質量比）で併用することで効果を発揮するものであり、上記のジェル状歯磨剤組成物に配合する、前記有効成分のみからなるべたつき抑制剤として使用することができる。また、これら成分をべたつき抑制の有効成分とし、その他の成分を更に添加して、ジェル状歯磨剤組成物用のべたつき抑制剤として調製することもできる。
なおこの場合、（Ａ）、（Ｂ）及び（Ｃ）成分、更には（Ｄ）成分、これらの配合量や配合割合、その他の成分等の詳細は、いずれも上記ジェル状歯磨剤組成物と同様である。 Further, the stickiness inhibitor of the present invention is (A) a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% sorbitol and not containing an abrasive, comprising (B) menthol and (C ) N-ethyl-p-menthane-3-carboxamide, more preferably (D) eugenol, wherein (B) / (C) has a mass ratio of 0.5 to 40.
Here, the components (B) and (C), more preferably the component (D) are effective components for suppressing stickiness, and the components (B) and (C) are used in combination at a specific blending ratio (mass ratio). It can be used as a stickiness inhibitor composed of only the above-mentioned active ingredient, which is blended into the gel dentifrice composition. Further, these components can be used as stickiness suppressing agents for gel dentifrice compositions by adding these components as active ingredients for stickiness suppression and further adding other components.
In this case, the details of the components (A), (B) and (C), further the component (D), the blending amount and blending ratio thereof, and other components are all the same as the gel dentifrice composition. It is the same.
ここで、（Ｂ）及び（Ｃ）成分、更に好ましくは（Ｄ）成分が、べたつき抑制の有効成分であり、（Ｂ）及び（Ｃ）成分は特定の配合割合（質量比）で併用することで効果を発揮するものであり、上記のジェル状歯磨剤組成物に配合する、前記有効成分のみからなるべたつき抑制剤として使用することができる。また、これら成分をべたつき抑制の有効成分とし、その他の成分を更に添加して、ジェル状歯磨剤組成物用のべたつき抑制剤として調製することもできる。
なおこの場合、（Ａ）、（Ｂ）及び（Ｃ）成分、更には（Ｄ）成分、これらの配合量や配合割合、その他の成分等の詳細は、いずれも上記ジェル状歯磨剤組成物と同様である。 Further, the stickiness inhibitor of the present invention is (A) a stickiness inhibitor for a gel dentifrice composition containing 40 to 60% sorbitol and not containing an abrasive, comprising (B) menthol and (C ) N-ethyl-p-menthane-3-carboxamide, more preferably (D) eugenol, wherein (B) / (C) has a mass ratio of 0.5 to 40.
Here, the components (B) and (C), more preferably the component (D) are effective components for suppressing stickiness, and the components (B) and (C) are used in combination at a specific blending ratio (mass ratio). It can be used as a stickiness inhibitor composed of only the above-mentioned active ingredient, which is blended into the gel dentifrice composition. Further, these components can be used as stickiness suppressing agents for gel dentifrice compositions by adding these components as active ingredients for stickiness suppression and further adding other components.
In this case, the details of the components (A), (B) and (C), further the component (D), the blending amount and blending ratio thereof, and other components are all the same as the gel dentifrice composition. It is the same.
以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において％は特に断らない限りいずれも質量％を示す。
Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
［実施例、比較例］
表１～３に示す組成のジェル状歯磨剤組成物を常法により調製した。
ジェル状歯磨剤組成物の調製には、ソルビトール（三菱商事フードテック（株）製）、メントール（高砂香料工業（株）製、Ｌ－メントール）、Ｎ－エチル－ｐ－メンタン－３－カルボキサミド（ジボダンジャパン（株）製、商品名；ＷＳ－３）、オイゲノール（豊玉香料（株）製）を用いた。配合量は、純分量である。
これら以外の成分は、外原規（医薬部外品原料規格）規格品、精製水は粧原基（化粧品原料基準）規格品を用いた。使用した香料Ａは、一般的な口腔用香料であり、メントール、Ｎ－エチル－ｐ－メンタン－３－カルボキサミド及びオイゲノールは含まれない。香料Ａの組成を下記に示す。
香料Ａの組成；
シネオール ２０質量部
リモネン １０
メントン ２０
カルボン １０
アネトール ２０
エタノール ２０
合計 １００質量部 [Examples and Comparative Examples]
Gel dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method.
For preparation of the gel dentifrice composition, sorbitol (manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), menthol (manufactured by Takasago International Corporation, L-menthol), N-ethyl-p-menthane-3-carboxamide ( Gibodan Japan Co., Ltd., trade name: WS-3) and Eugenol (Toyotama Fragrance Co., Ltd.) were used. The blending amount is a pure amount.
The other ingredients were used as standard products for the outer general standards (quasi-drug raw material standards), and the purified water was used as the standard for the cosmetic base (cosmetic raw material standards). The perfume A used is a general oral perfume and does not contain menthol, N-ethyl-p-menthane-3-carboxamide and eugenol. The composition of perfume A is shown below.
Composition of perfume A;
Cineol 20 parts by weight Limonene 10
Mentone 20
Carvone 10
Anethol 20
Ethanol 20
Total 100 parts by mass
表１～３に示す組成のジェル状歯磨剤組成物を常法により調製した。
ジェル状歯磨剤組成物の調製には、ソルビトール（三菱商事フードテック（株）製）、メントール（高砂香料工業（株）製、Ｌ－メントール）、Ｎ－エチル－ｐ－メンタン－３－カルボキサミド（ジボダンジャパン（株）製、商品名；ＷＳ－３）、オイゲノール（豊玉香料（株）製）を用いた。配合量は、純分量である。
これら以外の成分は、外原規（医薬部外品原料規格）規格品、精製水は粧原基（化粧品原料基準）規格品を用いた。使用した香料Ａは、一般的な口腔用香料であり、メントール、Ｎ－エチル－ｐ－メンタン－３－カルボキサミド及びオイゲノールは含まれない。香料Ａの組成を下記に示す。
香料Ａの組成；
シネオール ２０質量部
リモネン １０
メントン ２０
カルボン １０
アネトール ２０
エタノール ２０
合計 １００質量部 [Examples and Comparative Examples]
Gel dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method.
For preparation of the gel dentifrice composition, sorbitol (manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), menthol (manufactured by Takasago International Corporation, L-menthol), N-ethyl-p-menthane-3-carboxamide ( Gibodan Japan Co., Ltd., trade name: WS-3) and Eugenol (Toyotama Fragrance Co., Ltd.) were used. The blending amount is a pure amount.
The other ingredients were used as standard products for the outer general standards (quasi-drug raw material standards), and the purified water was used as the standard for the cosmetic base (cosmetic raw material standards). The perfume A used is a general oral perfume and does not contain menthol, N-ethyl-p-menthane-3-carboxamide and eugenol. The composition of perfume A is shown below.
Composition of perfume A;
Cineol 20 parts by weight Limonene 10
Mentone 20
Carvone 10
Anethol 20
Ethanol 20
Total 100 parts by mass
調製したジェル状歯磨剤組成物の使用感について、下記評価を行った。
１０名の被験者が、１ｇのジェル状歯磨剤組成物を歯ブラシ（ライオン（株）、デンターシステマ、ライオンハブラシ、レギュラー）にとり、３分間ブラッシングした後、口腔内で感じるべたつきのなさ、刺激のなさ、サッパリ感、香味発現性（香味発現のよさ）のそれぞれについて、相対評価又は絶対評価での官能試験を行い、下記の評点基準によって判定した。１０名の評点の平均値を求め、下記の評価基準で評価した。結果を表１～３に示す。
ここで、「べたつき」とは、湿潤剤に由来する（べっとりとした質の）甘さが口に残る感覚、「刺激」とは、口腔内がピリピリするような刺激の感覚である。 The following evaluation was performed about the usability | use_condition of the prepared gel-like dentifrice composition.
10 subjects took 1g of gel dentifrice composition on a toothbrush (Lion Corporation, Dentist System, Lion toothbrush, regular), brushed for 3 minutes, and then felt non-sticky and unstimulated in the oral cavity. For each of the refreshing feeling and flavor expression (good flavor expression), a sensory test was performed by relative evaluation or absolute evaluation, and judged according to the following score criteria. The average value of the scores of 10 people was calculated and evaluated according to the following evaluation criteria. The results are shown in Tables 1 to 3.
Here, “stickiness” is a sensation in which the sweetness (moist quality) derived from the wetting agent remains in the mouth, and “stimulation” is a sensation of irritation in the mouth.
１０名の被験者が、１ｇのジェル状歯磨剤組成物を歯ブラシ（ライオン（株）、デンターシステマ、ライオンハブラシ、レギュラー）にとり、３分間ブラッシングした後、口腔内で感じるべたつきのなさ、刺激のなさ、サッパリ感、香味発現性（香味発現のよさ）のそれぞれについて、相対評価又は絶対評価での官能試験を行い、下記の評点基準によって判定した。１０名の評点の平均値を求め、下記の評価基準で評価した。結果を表１～３に示す。
ここで、「べたつき」とは、湿潤剤に由来する（べっとりとした質の）甘さが口に残る感覚、「刺激」とは、口腔内がピリピリするような刺激の感覚である。 The following evaluation was performed about the usability | use_condition of the prepared gel-like dentifrice composition.
10 subjects took 1g of gel dentifrice composition on a toothbrush (Lion Corporation, Dentist System, Lion toothbrush, regular), brushed for 3 minutes, and then felt non-sticky and unstimulated in the oral cavity. For each of the refreshing feeling and flavor expression (good flavor expression), a sensory test was performed by relative evaluation or absolute evaluation, and judged according to the following score criteria. The average value of the scores of 10 people was calculated and evaluated according to the following evaluation criteria. The results are shown in Tables 1 to 3.
Here, “stickiness” is a sensation in which the sweetness (moist quality) derived from the wetting agent remains in the mouth, and “stimulation” is a sensation of irritation in the mouth.
（ｉ）べたつきのなさ
（評点）
４点：べたつきを全く感じない
３点：べたつきをほとんど感じない
２点：べたつきを感じる
１点：べたつきを非常に感じる
（評価基準）
べたつきのなさの平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (I) No stickiness (rating)
4 points: No stickiness 3 points: Little stickiness 2 points: Stickiness 1 point: Very sticky (Evaluation criteria)
Average point of non-stickiness ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and 2 Less than 0 points
（評点）
４点：べたつきを全く感じない
３点：べたつきをほとんど感じない
２点：べたつきを感じる
１点：べたつきを非常に感じる
（評価基準）
べたつきのなさの平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (I) No stickiness (rating)
4 points: No stickiness 3 points: Little stickiness 2 points: Stickiness 1 point: Very sticky (Evaluation criteria)
Average point of non-stickiness ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and 2 Less than 0 points
（ｉｉ）刺激のなさ
（評点）
４点：刺激を全く感じない
３点：刺激をほとんど感じない
２点：刺激を感じる
１点：刺激を非常に感じる
（評価基準）
刺激のなさの平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Ii) No stimulation (score)
4 points: I do not feel any stimulation 3 points: I hardly feel stimulation 2 points: I feel stimulation 1 point: I feel stimulation very much (evaluation criteria)
Average point of no stimulation ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and 2 Less than 0 points
（評点）
４点：刺激を全く感じない
３点：刺激をほとんど感じない
２点：刺激を感じる
１点：刺激を非常に感じる
（評価基準）
刺激のなさの平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Ii) No stimulation (score)
4 points: I do not feel any stimulation 3 points: I hardly feel stimulation 2 points: I feel stimulation 1 point: I feel stimulation very much (evaluation criteria)
Average point of no stimulation ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and 2 Less than 0 points
（ｉｉｉ）サッパリ感
（評点）
４点：サッパリ感を非常に感じる
３点：サッパリ感を感じる
２点：サッパリ感をやや感じる
１点：サッパリ感を全く感じない
（評価基準）
サッパリ感の平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Iii) Refreshing feeling (score)
4 points: I feel a refreshing feeling 3 points: I feel a feeling of refreshing 2 points: I feel a feeling of refreshing slightly 1 point: I do not feel a feeling of refreshing at all (evaluation criteria)
Average point of refreshing feeling ◎: 3.5 point or more and 4.0 point or less ○: 3.0 point or more and less than 3.5 point Δ: 2.0 point or more and less than 3.0 point ×: 1.0 point or more and 2. Less than 0
（評点）
４点：サッパリ感を非常に感じる
３点：サッパリ感を感じる
２点：サッパリ感をやや感じる
１点：サッパリ感を全く感じない
（評価基準）
サッパリ感の平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Iii) Refreshing feeling (score)
4 points: I feel a refreshing feeling 3 points: I feel a feeling of refreshing 2 points: I feel a feeling of refreshing slightly 1 point: I do not feel a feeling of refreshing at all (evaluation criteria)
Average point of refreshing feeling ◎: 3.5 point or more and 4.0 point or less ○: 3.0 point or more and less than 3.5 point Δ: 2.0 point or more and less than 3.0 point ×: 1.0 point or more and 2. Less than 0
（ｉｖ）香味発現性
（評点）
４点：香味発現が非常に良い
３点：香味発現が良い
２点：香味発現がやや良い
１点：香味発現が良くない
（評価基準）
香味発現性の平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Iv) Flavor expression (score)
4 points: very good flavor expression 3 points: good flavor expression 2 points: slightly good flavor expression 1 point: poor flavor expression (evaluation criteria)
Average score for flavor development ◎: 3.5 to 4.0 points ○: 3.0 to less than 3.5 points △: 2.0 to less than 3.0 points ×: 1.0 to 2 Less than 0 points
（評点）
４点：香味発現が非常に良い
３点：香味発現が良い
２点：香味発現がやや良い
１点：香味発現が良くない
（評価基準）
香味発現性の平均点
◎：３．５点以上４．０点以下
○：３．０点以上３．５点未満
△：２．０点以上３．０点未満
×：１．０点以上２．０点未満 (Iv) Flavor expression (score)
4 points: very good flavor expression 3 points: good flavor expression 2 points: slightly good flavor expression 1 point: poor flavor expression (evaluation criteria)
Average score for flavor development ◎: 3.5 to 4.0 points ○: 3.0 to less than 3.5 points △: 2.0 to less than 3.0 points ×: 1.0 to 2 Less than 0 points
表１、２に示すように、本発明のジェル状歯磨剤組成物（実施例）は、べたつきのなさが優れ、刺激のなさ、サッパリ感及び香味発現性も優れた。これに対して、表３に示すように、（Ｂ）及び／又は（Ｃ）成分を欠くと、べたつきのなさが劣り、サッパリ感及び香味発現性も劣った（比較例１～３）。また、（Ｂ）／（Ｃ）が大きすぎると、（Ｂ）及び（Ｃ）成分を含有してもべたつきのなさが劣り、刺激が強まった。香味発現も抑えられてしまった（比較例４）。
As shown in Tables 1 and 2, the gel dentifrice compositions (Examples) of the present invention were excellent in non-stickiness, inferior in irritation, refreshing and flavor development. On the other hand, as shown in Table 3, when the components (B) and / or (C) were absent, the non-stickiness was inferior, and the refreshing feeling and flavor expression were also inferior (Comparative Examples 1 to 3). Moreover, when (B) / (C) was too large, even if it contained (B) and (C) component, the non-stickiness was inferior and irritation | stimulation became strong. The flavor expression was also suppressed (Comparative Example 4).
［実施例２１］ジェル状歯磨剤
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．２５
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．１
（Ｄ）クローブ油（大洋香料（株）製） オイゲノールとして０．０２
トコフェロール酢酸エステル ０．６
トラネキサム酸 ０．０５
イソプロピルメチルフェノール ０．０５
フッ化ナトリウム ０．２
キサンタンガム １．０
アルギン酸プロピレングリコールエステル ０．１
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ３．０
カラギーナン ０．８
ポリエチレングリコール４０００ ０．４
ラウロイルメチルタウリンナトリウム ０．６
ポリオキシエチレン（２０）硬化ヒマシ油 １．２
ポリオキシエチレン（５）ステアリルエーテル １．２
リン酸二水素ナトリウム ０．５
硫酸ナトリウム １．０
水酸化ナトリウム ０．１
香料Ａ ０．５
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝２．５、（Ｄ）／（Ｃ）＝０．２ [Example 21] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.25
(C) N-ethyl-p-menthane-3-carboxamide 0.1
(D) Clove oil (manufactured by Taiyo Fragrance Co., Ltd.) 0.02 as eugenol
Tocopherol acetate 0.6
Tranexamic acid 0.05
Isopropyl methylphenol 0.05
Sodium fluoride 0.2
Xanthan gum 1.0
Alginic acid propylene glycol ester 0.1
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 3.0
Carrageenan 0.8
Polyethylene glycol 4000 0.4
Lauroylmethyl taurine sodium 0.6
Polyoxyethylene (20) hydrogenated castor oil 1.2
Polyoxyethylene (5) stearyl ether 1.2
Sodium dihydrogen phosphate 0.5
Sodium sulfate 1.0
Sodium hydroxide 0.1
Fragrance A 0.5
Purified water balance
Total 100%
(B) / (C) = 2.5, (D) / (C) = 0.2
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．２５
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．１
（Ｄ）クローブ油（大洋香料（株）製） オイゲノールとして０．０２
トコフェロール酢酸エステル ０．６
トラネキサム酸 ０．０５
イソプロピルメチルフェノール ０．０５
フッ化ナトリウム ０．２
キサンタンガム １．０
アルギン酸プロピレングリコールエステル ０．１
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ３．０
カラギーナン ０．８
ポリエチレングリコール４０００ ０．４
ラウロイルメチルタウリンナトリウム ０．６
ポリオキシエチレン（２０）硬化ヒマシ油 １．２
ポリオキシエチレン（５）ステアリルエーテル １．２
リン酸二水素ナトリウム ０．５
硫酸ナトリウム １．０
水酸化ナトリウム ０．１
香料Ａ ０．５
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝２．５、（Ｄ）／（Ｃ）＝０．２ [Example 21] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.25
(C) N-ethyl-p-menthane-3-carboxamide 0.1
(D) Clove oil (manufactured by Taiyo Fragrance Co., Ltd.) 0.02 as eugenol
Tocopherol acetate 0.6
Tranexamic acid 0.05
Isopropyl methylphenol 0.05
Sodium fluoride 0.2
Xanthan gum 1.0
Alginic acid propylene glycol ester 0.1
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 3.0
Carrageenan 0.8
Polyethylene glycol 4000 0.4
Lauroylmethyl taurine sodium 0.6
Polyoxyethylene (20) hydrogenated castor oil 1.2
Polyoxyethylene (5) stearyl ether 1.2
Sodium dihydrogen phosphate 0.5
Sodium sulfate 1.0
Sodium hydroxide 0.1
Fragrance A 0.5
Purified water balance
Total 100%
(B) / (C) = 2.5, (D) / (C) = 0.2
［実施例２２］ジェル状歯磨剤
（Ａ）ソルビトール ４５％
（Ｂ）メントール ０．２５
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．１５
トコフェロール酢酸エステル ０．６
アスコルビン酸リン酸マグネシウム ０．３
イソプロピルメチルフェノール ０．０５
モノフルオロリン酸ナトリウム ０．７
キサンタンガム １．０
アルギン酸プロピレングリコールエステル ０．１
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ５．０
カラギーナン ０．８
ポリエチレングリコール４０００ ０．４
ラウロイルメチルタウリンナトリウム ０．６
ポリオキシエチレン（２０）硬化ヒマシ油 １．２
ポリオキシエチレン（５）ステアリルエーテル １．２
リン酸二水素ナトリウム ０．５
硫酸ナトリウム １．０
水酸化ナトリウム ０．３
クエン酸 ０．１
香料Ａ ０．５
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１．６７ [Example 22] Gel dentifrice (A) Sorbitol 45%
(B) Menthol 0.25
(C) N-ethyl-p-menthane-3-carboxamide 0.15
Tocopherol acetate 0.6
Magnesium ascorbate phosphate 0.3
Isopropyl methylphenol 0.05
Sodium monofluorophosphate 0.7
Xanthan gum 1.0
Alginic acid propylene glycol ester 0.1
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 5.0
Carrageenan 0.8
Polyethylene glycol 4000 0.4
Lauroylmethyl taurine sodium 0.6
Polyoxyethylene (20) hydrogenated castor oil 1.2
Polyoxyethylene (5) stearyl ether 1.2
Sodium dihydrogen phosphate 0.5
Sodium sulfate 1.0
Sodium hydroxide 0.3
Citric acid 0.1
Fragrance A 0.5
Purified water balance
Total 100%
(B) / (C) = 1.67
（Ａ）ソルビトール ４５％
（Ｂ）メントール ０．２５
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．１５
トコフェロール酢酸エステル ０．６
アスコルビン酸リン酸マグネシウム ０．３
イソプロピルメチルフェノール ０．０５
モノフルオロリン酸ナトリウム ０．７
キサンタンガム １．０
アルギン酸プロピレングリコールエステル ０．１
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ５．０
カラギーナン ０．８
ポリエチレングリコール４０００ ０．４
ラウロイルメチルタウリンナトリウム ０．６
ポリオキシエチレン（２０）硬化ヒマシ油 １．２
ポリオキシエチレン（５）ステアリルエーテル １．２
リン酸二水素ナトリウム ０．５
硫酸ナトリウム １．０
水酸化ナトリウム ０．３
クエン酸 ０．１
香料Ａ ０．５
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１．６７ [Example 22] Gel dentifrice (A) Sorbitol 45%
(B) Menthol 0.25
(C) N-ethyl-p-menthane-3-carboxamide 0.15
Tocopherol acetate 0.6
Magnesium ascorbate phosphate 0.3
Isopropyl methylphenol 0.05
Sodium monofluorophosphate 0.7
Xanthan gum 1.0
Alginic acid propylene glycol ester 0.1
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 5.0
Carrageenan 0.8
Polyethylene glycol 4000 0.4
Lauroylmethyl taurine sodium 0.6
Polyoxyethylene (20) hydrogenated castor oil 1.2
Polyoxyethylene (5) stearyl ether 1.2
Sodium dihydrogen phosphate 0.5
Sodium sulfate 1.0
Sodium hydroxide 0.3
Citric acid 0.1
Fragrance A 0.5
Purified water balance
Total 100%
(B) / (C) = 1.67
［実施例２３］ジェル状歯磨剤
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．２
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．０２
塩化セチルピリジニウム ０．０２
フッ化ナトリウム ０．２
アルギン酸ナトリウム ０．６
増粘性シリカ ４．５
サッカリンナトリウム ０．１
プロピレングリコール ５．０
キサンタンガム １．１
ポリオキシエチレン（２０）硬化ヒマシ油 ３．０
香料Ａ ０．３
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１０ [Example 23] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.2
(C) N-ethyl-p-menthane-3-carboxamide 0.02
Cetylpyridinium chloride 0.02
Sodium fluoride 0.2
Sodium alginate 0.6
Thickening silica 4.5
Saccharin sodium 0.1
Propylene glycol 5.0
Xanthan gum 1.1
Polyoxyethylene (20) hydrogenated castor oil 3.0
Fragrance A 0.3
Purified water balance
Total 100%
(B) / (C) = 10
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．２
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．０２
塩化セチルピリジニウム ０．０２
フッ化ナトリウム ０．２
アルギン酸ナトリウム ０．６
増粘性シリカ ４．５
サッカリンナトリウム ０．１
プロピレングリコール ５．０
キサンタンガム １．１
ポリオキシエチレン（２０）硬化ヒマシ油 ３．０
香料Ａ ０．３
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１０ [Example 23] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.2
(C) N-ethyl-p-menthane-3-carboxamide 0.02
Cetylpyridinium chloride 0.02
Sodium fluoride 0.2
Sodium alginate 0.6
Thickening silica 4.5
Saccharin sodium 0.1
Propylene glycol 5.0
Xanthan gum 1.1
Polyoxyethylene (20) hydrogenated castor oil 3.0
Fragrance A 0.3
Purified water balance
Total 100%
(B) / (C) = 10
［実施例２４］ジェル状歯磨剤
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．６
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．０６
（Ｄ）オイゲノール ０．０５
トコフェロール酢酸エステル ０．１
トラネキサム酸 ０．０５
イソプロピルメチルフェノール ０．１
フッ化ナトリウム ０．２
ラウロイルサルコシンナトリウム ０．２
アルギン酸ナトリウム ０．６
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ３．５
キサンタンガム １．４
ポリエチレングリコール４０００ １．０
ラウリル硫酸ナトリウム １．３
ポリオキシエチレン（２０）硬化ヒマシ油 １．５
ポリオキシエチレン（５）ステアリルエーテル １．５
硫酸ナトリウム １．０
香料Ａ １．０
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１０、（Ｄ）／（Ｃ）＝０．８３ [Example 24] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.6
(C) N-ethyl-p-menthane-3-carboxamide 0.06
(D) Eugenol 0.05
Tocopherol acetate 0.1
Tranexamic acid 0.05
Isopropylmethylphenol 0.1
Sodium fluoride 0.2
Lauroyl sarcosine sodium 0.2
Sodium alginate 0.6
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 3.5
Xanthan gum 1.4
Polyethylene glycol 4000 1.0
Sodium lauryl sulfate 1.3
Polyoxyethylene (20) hydrogenated castor oil 1.5
Polyoxyethylene (5) stearyl ether 1.5
Sodium sulfate 1.0
Fragrance A 1.0
Purified water balance
Total 100%
(B) / (C) = 10, (D) / (C) = 0.83
（Ａ）ソルビトール ４０％
（Ｂ）メントール ０．６
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミド ０．０６
（Ｄ）オイゲノール ０．０５
トコフェロール酢酸エステル ０．１
トラネキサム酸 ０．０５
イソプロピルメチルフェノール ０．１
フッ化ナトリウム ０．２
ラウロイルサルコシンナトリウム ０．２
アルギン酸ナトリウム ０．６
増粘性シリカ ６．０
サッカリンナトリウム ０．１
プロピレングリコール ３．５
キサンタンガム １．４
ポリエチレングリコール４０００ １．０
ラウリル硫酸ナトリウム １．３
ポリオキシエチレン（２０）硬化ヒマシ油 １．５
ポリオキシエチレン（５）ステアリルエーテル １．５
硫酸ナトリウム １．０
香料Ａ １．０
精製水 バランス
合計 １００％
（Ｂ）／（Ｃ）＝１０、（Ｄ）／（Ｃ）＝０．８３ [Example 24] Gel dentifrice (A) Sorbitol 40%
(B) Menthol 0.6
(C) N-ethyl-p-menthane-3-carboxamide 0.06
(D) Eugenol 0.05
Tocopherol acetate 0.1
Tranexamic acid 0.05
Isopropylmethylphenol 0.1
Sodium fluoride 0.2
Lauroyl sarcosine sodium 0.2
Sodium alginate 0.6
Thickening silica 6.0
Saccharin sodium 0.1
Propylene glycol 3.5
Xanthan gum 1.4
Polyethylene glycol 4000 1.0
Sodium lauryl sulfate 1.3
Polyoxyethylene (20) hydrogenated castor oil 1.5
Polyoxyethylene (5) stearyl ether 1.5
Sodium sulfate 1.0
Fragrance A 1.0
Purified water balance
Total 100%
(B) / (C) = 10, (D) / (C) = 0.83
Claims (6)
- （Ａ）ソルビトールを４０～６０質量％、
（Ｂ）メントールを０．１～１質量％、及び
（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドを０．０２～０．２質量％
含有し、（Ｂ）／（Ｃ）が質量比として０．５～４０であり、研磨剤を含有しないジェル状歯磨剤組成物。 (A) 40-60 mass% sorbitol,
(B) 0.1 to 1% by mass of menthol and (C) 0.02 to 0.2% by mass of N-ethyl-p-menthane-3-carboxamide
A gel dentifrice composition containing (B) / (C) in a mass ratio of 0.5 to 40 and containing no abrasive. - 更に、（Ｄ）オイゲノールを０．０１～０．１質量％含有する請求項１記載のジェル状歯磨剤組成物。 The gel dentifrice composition according to claim 1, further comprising (D) 0.01 to 0.1% by mass of eugenol.
- （Ｄ）／（Ｃ）が質量比として０．０５～５である請求項２記載のジェル状歯磨剤組成物。 The gel dentifrice composition according to claim 2, wherein (D) / (C) is 0.05 to 5 as a mass ratio.
- （Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。 (A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
A stickiness inhibitor comprising (B) menthol and (C) N-ethyl-p-menthane-3-carboxamide, wherein (B) / (C) has a mass ratio of 0.5 to 40. - （Ａ）ソルビトールを４０～６０質量％含有する、研磨剤を含まないジェル状歯磨剤組成物用のべたつき抑制剤であって、
（Ｂ）メントールと、（Ｃ）Ｎ－エチル－ｐ－メンタン－３－カルボキサミドと、（Ｄ）オイゲノールとからなり、（Ｂ）／（Ｃ）が質量比として０．５～４０であるべたつき抑制剤。 (A) A stickiness inhibitor for a gel dentifrice composition containing 40 to 60% by mass of sorbitol and not containing an abrasive,
(B) Menthol, (C) N-ethyl-p-menthane-3-carboxamide, and (D) eugenol, (B) / (C) having a mass ratio of 0.5-40 Agent. - （Ｄ）／（Ｃ）が質量比として０．０５～５である請求項５記載のべたつき抑制剤。 The stickiness inhibitor according to claim 5, wherein (D) / (C) is 0.05 to 5 as a mass ratio.
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| WO2016006647A1 (en) * | 2014-07-11 | 2016-01-14 | ライオン株式会社 | Composition for use in oral cavity |
| JP2016040306A (en) * | 2015-10-23 | 2016-03-24 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | Taste-masked oral care compositions |
| JP2016121089A (en) * | 2014-12-25 | 2016-07-07 | ライオン株式会社 | Oral composition |
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| JP3334425B2 (en) * | 1995-04-10 | 2002-10-15 | ライオン株式会社 | Liquid oral composition |
| AU2014232903A1 (en) * | 2013-03-15 | 2015-10-01 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
| CN107613948B (en) * | 2015-05-29 | 2021-02-09 | 狮王株式会社 | Oral composition |
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| JP2003026557A (en) * | 2001-07-13 | 2003-01-29 | Takayuki Kodama | Composition for oral cavity |
| JP2009221208A (en) * | 2004-08-12 | 2009-10-01 | Procter & Gamble Co | Composition for oral hygiene and its system |
| JP2010523551A (en) * | 2007-04-16 | 2010-07-15 | ザ プロクター アンド ギャンブル カンパニー | Personal care compositions comprising an essential oil or an antimicrobial mixture of essential oil components |
| JP2009120552A (en) * | 2007-11-16 | 2009-06-04 | Lion Corp | Method for manufacturing toothpaste agent composition |
| JP2011530608A (en) * | 2008-08-15 | 2011-12-22 | ザ プロクター アンド ギャンブル カンパニー | Synthesis of cyclohexane derivatives useful as sensory agents in consumer products |
| JP2014125440A (en) * | 2012-12-26 | 2014-07-07 | Lion Corp | Composition for oral cavity |
| WO2016006647A1 (en) * | 2014-07-11 | 2016-01-14 | ライオン株式会社 | Composition for use in oral cavity |
| JP2016121089A (en) * | 2014-12-25 | 2016-07-07 | ライオン株式会社 | Oral composition |
| JP2016040306A (en) * | 2015-10-23 | 2016-03-24 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | Taste-masked oral care compositions |
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