JP2020026407A - Skin detergent composition - Google Patents

Abstract

To provide a skin detergent composition that has satisfactory detergency and forms a fine bubble while expressing excellent germicidal effect, and has excellent low-temperature storage stability.SOLUTION: The skin detergent composition is provided that contains the following components (A), (B), (C), (D) and (E): (A) 1.0 to 10 mass% of anionic surfactant expressed by a general formula (1) R-O-(CHCHO)-SOM (1)(in the formula, Rdenotes a hydrocarbon group with a carbon number 8 to 16, n denotes an average addition molar number, denotes the number of n=0 to 3, M denotes alkali metal, alkali earth metal, ammonium or alkanolammonium); (B) 0.5 to 5.0 mass% of glyceryl ether having a hydrocarbon group with a carbon number 4 to 22; (C) 0.01 to 0.8 mass% of at least one kind of germicidal agent selected from a group consisting of triclosan, isopropylmethylphenol and parachloromethaxylenol; (D) 0.5 to 7.0 mass% of alkyl glucoside; and (E) 0.5 to 15 mass% of saturated monohydric alcohol with a carbon number 1 to 3, wherein a mass ratio (B)/(E) between component (B) and component (E) is 0.10 to 5.SELECTED DRAWING: None

Description

  The present invention relates to a skin cleansing composition.

In recent years, in hospitals, nursing homes, food processing sites, kitchens, and the like, hand washing has been promoted for the purpose of preventing the spread of pathogenic bacteria through fingers. In such sites, various types of skin germicidal detergent compositions are used in order to more reliably perform germicidal washing of the skin.
The present applicant has also proposed, for example, a skin antiseptic cleansing composition containing a specific anionic surfactant, a bactericide and glyceryl ether (see Patent Documents 1 and 2).
On the other hand, we have proposed a liquid detergent composition for hard surface cleaning with excellent detergency, which uses alkyl glucoside, a mild nonionic surfactant for hand skin, as a main cleaning base and glyceryl ether in combination. Reference 3).

JP 2010-168555 A JP 2011-256301A JP 2008-106128 A

However, although the skin disinfectant cleaning compositions described in Patent Documents 1 and 2 have an excellent disinfecting effect, relatively coarse foams are generated, there is a problem in detergency, and actual use by users is difficult. In this case, it was difficult to realize that the washing and sterilization were carried out firmly.
Therefore, in order to improve the detergency, the alkyl glucoside described in Patent Document 3 was used in combination, but it was found that although the detergency was improved, the bactericidal effect was significantly reduced.

  Thus, the present inventors have conducted various studies and found that, together with a specific anionic surfactant, a bactericide, and an alkyl glucoside, a small amount of a saturated monohydric alcohol having 1 to 3 carbon atoms than the bactericidal effect is exhibited. By further using glyceryl ether at a specific ratio, it has been found that while exhibiting a high bactericidal effect, the detergency is improved, and the foam quality is finer, wrinkles of the hand as fine bubbles stick to the skin, The present inventors have found that a skin cleansing composition which spreads to a fine portion such as an indirect portion, a fingertip or a space between nails and is easy to conform to, and has an excellent feeling of cleaning can be obtained.

The invention comprises the following components (A), (B), (C), (D) and (E):
(A) General formula (1)
R ¹ —O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average addition mole number, n represents a number of 0 to 3, and M represents an alkali metal, an alkaline earth metal, ammonium or Alkanol ammonium)
Anionic surfactant represented by 1.0 to 10% by mass,
(B) glyceryl ether having a hydrocarbon group having 4 to 22 carbon atoms, 0.5 to 5.0% by mass,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass;
(D) alkyl glucoside 0.5 to 7% by mass,
(E) 0.5 to 15% by mass of a saturated monohydric alcohol having 1 to 3 carbon atoms
And a weight ratio (B) / (E) of the component (B) to the component (E) of 0.10 to 5 is related to the skin cleansing composition.

  The skin cleanser composition of the present invention is excellent in detergency and fineness of foam while exhibiting an excellent bactericidal effect. Especially at the time of use, the foam quality is fine, and it spreads easily to fine parts such as wrinkles of hands, joints, fingertips and nails so that fine bubbles stick to the skin, it is easy to fit in, and the user thoroughly cleans and sterilizes It is possible to obtain a feeling that the washing is performed.

The anionic surfactant of the component (A) used in the present invention is represented by the general formula (1).
In the formula, the hydrocarbon group represented by R ¹ is preferably a saturated or unsaturated aliphatic hydrocarbon group having 8 to 16 carbon atoms, and is preferably an alkyl group having 10 to 16 carbon atoms, from the viewpoint of achieving both sterilization and detergency. Groups are more preferred. Although the thing of 0-3 is used as an average addition mole number n, 0-1 is preferable from a viewpoint of improving sterilization performance. Examples of M include sodium, potassium, lithium, calcium, ammonium, triethanolammonium, diethanolammonium, and monoethanolammonium. From the viewpoint of sterilization performance, ammonium is preferred.

As the component (A), for example, polyoxyethylene (0) alkyl ether triethanolamine sulfate (triethanolamine alkyl sulfate), polyoxyethylene (0) alkyl ether ammonium sulfate (alkyl ammonium sulfate), polyoxyethylene (0) alkyl Sodium ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) alkyl ether triethanolamine sulfate, polyoxyethylene (1) alkyl ether ammonium sulfate, polyoxyethylene (2) alkyl ether ammonium sulfate, polyoxyethylene (2) alkyl ether Sodium sulfate and the like. Among these, polyoxyethylene (1) alkyl ether triethanolamine sulfate and polyoxyethylene (1) alkyl ether ammonium sulfate are preferred from the viewpoints of foaming, sterilization performance, and skin irritation.
In addition, in this specification, the numerical value in the parenthesis of these compounds means the average addition mole number of ethylene oxide.

  The component (A) can be used alone or in combination of two or more. The content is required to be 1.0% by mass or more in the total composition from the viewpoint of achieving both sterilization and fineness of foam. 1.3% by mass or more is preferable, 1.6% by mass or more is more preferable, 2.0% by mass or more is more preferable, 10% by mass or less is necessary, and 8.0% by mass or less is preferable. 5.0 mass% or less is more preferable, and 4.0 mass% or less is further more preferable. Further, the content of the component (A) needs to be 1.0 to 10% by mass in the whole composition, preferably 1.3 to 8.0% by mass, and 1.6 to 5.0% by mass. %, More preferably 2.0 to 4.0% by mass.

  Component (B) is a glyceryl ether having a hydrocarbon group having 4 to 22 carbon atoms. From the viewpoint of improving storage stability and sterilization, a glyceryl ether having a linear or branched alkyl group or alkenyl group having 6 to 18 carbon atoms is preferable, and a linear or branched alkyl group having 8 to 12 carbon atoms is preferable. Monoalkyl having a group is more preferred.

  Examples of the linear or branched alkyl group having 8 to 22 carbon atoms include n-octyl, 2-ethylhexyl, n-nonyl, n-decyl, isodecyl, n-undecyl, and n-dodecyl. Groups. Among these, a branched alkyl group having 8 to 12 carbon atoms is preferable, a branched alkyl group having 8 to 10 carbon atoms is more preferable, and specifically a 2-ethylhexyl group, An isodecyl group is exemplified.

Specific examples of the component (B) include those containing one or more selected from glycerin mono-2-ethylhexyl ether, glycerin monoisodecyl ether and glycerin monoisostearyl ether. From the viewpoint of achieving both bactericidal properties, it is preferable to include one or two selected from glycerin mono-2-ethylhexyl ether and glycerin monoisodecyl ether, and glycerin mono-2-ethylhexyl ether and / or glycerin monoisodecyl. More preferably, it contains an ether.
As the component (B), commercially available products of glycerin mono-2-ethylhexyl ether (Penetol GE-EH, manufactured by Kao Corporation) and glycerin monoisodecyl ether (Penetol GE-ID, manufactured by Kao Corporation) are preferably used. be able to.

  Component (B) can be used alone or in combination of two or more, and the content is required to be 0.5% by mass or more in the whole composition from the viewpoint of improving storage stability and sterilization. 0.8 mass% or more is preferable, 1.0 mass% or more is more preferable, 1.5 mass% or more is more preferable, 5.0 mass% or less is necessary, and 4.0 mass% or less is It is preferably at most 3.0% by mass, more preferably at most 2.5% by mass. Further, the content of the component (B) needs to be 0.5 to 5.0% by mass in the whole composition, preferably 0.8 to 4.0% by mass, and 1.0 to 3.0% by mass. 0 mass% is more preferable, and 1.5 to 2.5 mass% is still more preferable.

The fungicide of the component (C) is at least one selected from the group consisting of triclosan, isopropylmethylphenol, and parachlorometaxylenol.
The content of the component (C) is required to be 0.01% by mass or more in the whole composition, preferably 0.02% by mass or more, and more preferably 0.05% by mass from the viewpoint of compatibility between storage stability and sterilization. The above is more preferable, 0.8 mass% or less is necessary, 0.5 mass% or less is preferable, and 0.3 mass% or less is more preferable. Further, the content of the component (C) needs to be 0.01 to 0.8% by mass in the whole composition, preferably 0.02 to 0.5% by mass, and more preferably 0.05 to 0.5% by mass. 3% by mass is more preferred.

Examples of the alkyl glucoside of the component (D) include an alkyl glucoside represented by the following general formula (2).
R ^2- (OR ³ ) _m G _p (2)
(Wherein, R ² represents a straight-chain alkyl group having 8 to 16 carbon atoms, R ³ represents an alkylene group having 2 to 4 carbon atoms, G represents a group derived from a reducing sugar, and m represents an average addition mole. Represents a number, represents a number from 0 to 5, and p represents an average degree of condensation and represents a number from 1 to 3)

  In the alkyl glucoside of the general formula (2), the reducing sugar as a raw material may be any of aldose and ketose, and includes triose, tetrose, pentose, and hexose having 3 to 6 carbon atoms. Specifically, aldose includes apiose, arabinose, galactose, glucose, lyxose, mannose, galose, aldose, idose, talose, and xylose, and ketose includes fructose. Of these, aldopentose or aldohexose having 5 or 6 carbon atoms is preferable, and glucose is more preferable.

  Examples of the alkyl glucoside of the component (D) include octyl polyglucoside, 2-ethylhexyl polyglucoside, decyl polyglucoside, lauryl polyglucoside, myristyl polyglucoside, palmityl polyglucoside, isostearyl polyglucoside, stearyl lauryl polyglucoside, and oleyl. And polyglucoside.

  The component (D) can be used alone or in combination of two or more, and the content is required to be 0.5% by mass or more in the entire composition from the viewpoint of achieving both sterilization and fineness of foam. 0.8 mass% or more is preferable, 1.5 mass% or more is more preferable, 2.5 mass% or more is more preferable, and it is necessary that it is 7.0 mass% or less, and 6.0 mass% or less is required. %, Preferably 5.0% by mass or less, more preferably 4.5% by mass or less. Further, the content of the component (D) needs to be 0.5 to 7.0% by mass in the whole composition, preferably 0.8 to 6.0% by mass, and 1.5% by mass. -5.0 mass% is more preferable, and 2.5-4.5 mass% is still more preferable.

  In the present invention, the mass ratio (B) / (D) of the component (B) to the component (D) is preferably at least 0.30, more preferably at least 0.35, from the viewpoint of achieving both sterilization and detergency. , 0.40 or more, more preferably 6, or less, more preferably 4, or less, and even more preferably 2, or less. The mass ratio of the component (B) to the component (D) is preferably from 0.30 to 6, more preferably from 0.35 to 4, and even more preferably from 0.40 to 2.

As the component (E), the saturated monohydric alcohol having 1 to 3 carbon atoms includes methanol, ethanol, propanol, isopropanol and the like. From the viewpoint of compatibility between detergency and bactericidal property, ethyl alcohol and / or isopropanol are preferred. , More preferably ethanol.
These components are used as germicidal / disinfecting alcohols, but a bactericidal effect can be obtained by containing them at a high concentration. For example, in the case of ethanol, a bactericidal effect can be obtained at a concentration of 40 to 80% by mass in the composition, and a practical bactericidal effect (killing time of bacteria within 5 minutes) can be obtained. On the other hand, when the concentration is as low as 15% by mass or less, bacterial growth is inhibited or a very weak bactericidal effect is obtained, and a practical bactericidal effect cannot be expected. However, in the present invention, together with a specific anionic surfactant, glyceryl ether, a bactericide, and an alkyl glucoside, a very small amount of a saturated monohydric alcohol having 1 to 3 carbon atoms than the bactericidal effect is expressed is converted into glyceryl ether and By containing at a ratio, a skin cleansing composition having excellent detergency and foam quality while exhibiting a high bactericidal effect can be obtained.

  The content of the component (E) is required to be 0.5% by mass or more in the entire composition, preferably 0.8% by mass or more, and more preferably 1.0% by mass or more from the viewpoint of compatibility between detergency and cleanability. Is more preferably 2.0% by mass or more, further preferably 15% by mass or less, preferably 10% by mass or less, more preferably 7.0% by mass or less, and even more preferably 4.0% by mass or less. Further, the content of the component (E) needs to be 0.5 to 15% by mass in the whole composition, preferably 0.8 to 10% by mass, and 1.0 to 7.0% by mass. More preferably, the content is more preferably 2.0 to 7.0% by mass, and even more preferably 2.0 to 4.0% by mass.

  In the present invention, the mass ratio (B) / (E) of the component (B) to the component (E) is 0.10 or more from the viewpoint of achieving both sterilization and cleaning properties and improving storage stability. 0.15 or more is preferable, 0.5 or more is more preferable, 5 or less, 2 or less is preferable, and 1.5 or less is further preferable. The mass ratio (B) / (E) of the component (B) to the component (E) is 0.10 to 5, preferably 0.15 to 2, and more preferably 0.5 to 1.5.

  Further, in the present invention, the mass ratio (A) / (E) of the component (A) to the component (E) is preferably 0.05 or more, more preferably 0.1 or more, from the viewpoint of improving detergency and foaming. Preferably, 0.3 or more is more preferable, 5 or less is preferable, 3 or less is more preferable, and 1.5 or less is further more preferable. Further, the mass ratio (A) / (E) of the component (A) to the component (E) is preferably 0.05 to 5, more preferably 0.1 to 3, and still more preferably 0.3 to 1.5. .

  In the present invention, the mass ratio (E) / (D) of the component (E) to the component (D) is preferably 0.05 or more from the viewpoint of foaming, improving cleanability, and maintaining sterility. 0.1 or more is more preferable, 0.5 or more is more preferable, 5 or less is preferable, 3 or less is more preferable, and 1.5 or less is further more preferable. Further, the mass ratio (E) / (D) of the component (E) to the component (D) is preferably 0.05 to 5, more preferably 0.1 to 3, and further preferably 0.5 to 1.5. .

The skin cleansing composition of the present invention contains (F) water as a solvent.
The water content of the component (F) can be appropriately set according to the amount of each component, and from the viewpoint of improving foaming and improving the rinsing speed, 60 to 95% by mass in the total composition. Preferably, it is more preferably 65 to 90% by mass, and still more preferably 70 to 85% by mass.

The skin cleansing composition of the present invention can further contain (G) a polyol from the viewpoint of making the foam fine and rinsing properties good.
Examples of such polyols include dihydric alcohols such as ethylene glycol, diethylene glycol, hexylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, and 1,3-butylene glycol; glycerin, diglycerin, triglycerol, and the like. Trihydric or higher alcohols such as glycerin, tetraglycerin, hexaglycerin, decaglycerin, and trimethylpropanol; erythritol, pentaerythritol, dipentaerythritol, glucose, mannose, galactose, sucrose, fructose, maltose, maltitol, xylitol, inositol, Examples thereof include sugars such as sorbitan and sorbitol, and sugar alcohols.
Among these, one or more selected from propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, 1,3-butylene glycol, and sorbitol, from the viewpoint of improving low-temperature stability and increasing a feeling of moisture after washing. Is preferably, one or more selected from propylene glycol, polypropylene glycol, glycerin and 1,3-butylene glycol are more preferable, and one or more selected from propylene glycol, polypropylene glycol and glycerin is further preferable, Further, it is preferable to contain at least glycerin.

  The polyol of the component (G) can be used alone or in combination of two or more, and the content is preferably 1% by mass or more in the whole composition from the viewpoint of improving foam quality and improving rinsing properties. The content is preferably 3% by mass or more, more preferably 5% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 9% by mass or less. Further, the content of the component (G) is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, and still more preferably 5 to 9% by mass in the whole composition.

The skin cleansing composition of the present invention may further contain (H) polyoxyethylene alkyl ether carboxylic acid or a salt thereof from the viewpoint of improving skin cleansing properties while maintaining sterility.
Examples of the polyoxyethylene alkyl ether carboxylic acid or a salt thereof of the component (H) include those represented by the general formula (3).

R ⁴ —O— (CH ₂ CH ₂ O) _q —CH ₂ —COOX (3)
(Wherein, R ⁴ represents an alkyl group having ⁴ to 22 carbon atoms, q represents a number of 0 to 20, and X represents a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium or organic ammonium)

In the formula, R ⁴ is an alkyl group having 4 to 22 carbon atoms, more preferably an alkyl group having 6 to 20 carbon atoms, and still more preferably 8 to 22 carbon atoms, from the viewpoint of improving detergency and low-temperature stability. It is an alkyl group having 18 and more preferably an alkyl group having 10 to 16 carbon atoms. The alkyl chain of R ⁴ may be either a straight chain or a branched chain, but is preferably a straight chain alkyl group from the viewpoint of foamability. In addition, the average carbon number of R ⁴ is preferably 10.8 to 12.8, more preferably 10.8 to 12 from the viewpoint of improving foaming properties and foam quality and further improving low-temperature stability. And more preferably 12.1 to 12.4.

In the formula, q represents a number of 0 to 20, and more preferably 0 to 12. In addition, q indicates the number of moles of ethylene oxide added, and the average number of moles of ethylene oxide (the average value of q) in the composition of the component (H) improves the foaming property and the foam quality, and further reduces the temperature. In light of improving stability, 1.5 to 10 is preferable, 2.5 to 6.4 is more preferable, 2.5 to 3.7 is more preferable, 2.5 to 3.4 is still more preferable, and 0.8-3.4 is more preferable, and 2.8-3.1 is more preferable.
For the measurement of the alkyl composition of the alkyl ether carboxylic acid, the addition molar distribution of ethylene oxide, and the ratio of each component, WO2012 / 029950 can be referred to.

  In the formula, X represents a hydrogen atom; an alkali metal such as sodium and potassium; an alkaline earth metal such as calcium and magnesium; ammonium; an ammonium derived from an alkanolamine such as monoethanolamine, diethanolamine and triethanolamine. No. Among these, alkali metals are preferred, and sodium and / or potassium are more preferred, from the viewpoint of improving foaming properties and low-temperature stability and not coloring over time.

As such a polyoxyethylene alkyl ether carboxylic acid or a salt thereof, specifically, polyoxyethylene lauryl ether carboxylic acid or a salt thereof, polyoxyethylene myristyl ether carboxylic acid or a salt thereof, and polyoxyethylene palmityl ether carboxylic acid Examples thereof include acids and salts thereof. Among these, from the viewpoint of improving foaming properties and foam quality, one or two selected from polyoxyethylene lauryl ether carboxylic acid or a salt thereof, and polyoxyethylene myristyl ether carboxylic acid or a salt thereof are included It is more preferable that it contains polyoxyethylene lauryl ether carboxylic acid or a salt thereof.
Examples of these commercially available products include Kaoakipo RLM-45 (manufactured by Kao Corporation), Kaoakipo RLM45CA (manufactured by Kao Corporation), and Kaoakipo LM 26C (manufactured by Kao Corporation).

  The content of the component (H) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and more preferably 0.2% by mass in the entire composition, from the viewpoint of improving foaming properties and foam quality. More preferably, the content is 2.0% by mass or less, more preferably 1.0% by mass or less, even more preferably 0.7% by mass or less. The content of the component (H) is preferably from 0.05 to 2.0% by mass, more preferably from 0.1 to 1.0% by mass, and still more preferably from 0.2 to 0.7% by mass in the whole composition. .

The skin cleansing composition of the present invention can further contain (I) cellulose to which a hydroxyethyl group or a hydroxypropyl group is added from the viewpoint of improving foam quality and foam persistence.
The cellulose of the component (I) is one in which a part of hydrogen atoms in a hydroxyl group of the cellulose is substituted with a hydroxyethyl group or a hydroxypropyl group, and may have a substituent other than these.

Specific examples include hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxypropylmethylcellulose, and the like.
These are obtained by reacting cellulose with caustic soda to form alkali cellulose, and then reacting with methyl chloride, monochloroacetic acid, ethylene oxide, propylene oxide, etc., to replace the hydrogen atom in the hydroxyl group of cellulose.

The average degree of substitution of the cellulose of the component (I) is more than 0, preferably 0.5 or more, more preferably 3 or less, and more preferably 2 or less, from the viewpoint of the effect of improving the foam durability. In addition, the average molecular weight is preferably 200,000 or more, more preferably 500,000 or more, more preferably 650,000 or more, from the viewpoint of the effects of solubility in the skin cleansing composition and foam sustainability. It is preferably at most 1,000,000, more preferably at most 2,000,000, and still more preferably at most 1,600,000.
In the present invention, the average degree of substitution is determined by NMR, and the average molecular weight is determined by using a gel permeation chromatography (GPC) -multiangle laser light scattering detector (MALLS) system using polyethylene oxide as a standard substance. Measured.

  As the component (I), hydroxyethylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose are preferable, and those having an average degree of substitution of 0.5 to 2 and an average molecular weight of 650,000 to 1,600,000 are preferable.

  In addition, as the component (I), for example, hydroxyethyl cellulose includes CELLOSIZE QP52000H (manufactured by Dow Chemical Company), HEC Daicel SE400, SE500, SE600, SE850, SE900 (manufactured by Daicel FineChem) and the like; , HPC-H, HPC-M (manufactured by Nippon Soda Co., Ltd.); hydroxypropyl methylcellulose includes METROLOSE 60SH, 65SH (manufactured by Shin-Etsu Chemical Co., Ltd.), BENECEL E50, E4M, E10M, F4MC, K99C, K4M, K15M, Commercial products such as K35M, K100M, and K200M (all manufactured by ASHLAND) can be used.

  As the component (I), one or more kinds can be used, and the content is preferably 0.1% by mass or more in the whole composition from the viewpoint of making the foam finer and improving the foam sustainability. , 0.5% by mass or more, still more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 2% by mass or less. Further, the content of the component (I) is preferably from 0.1 to 5% by mass, more preferably from 0.5 to 3% by mass, even more preferably from 1 to 2% by mass in the whole composition.

  The skin cleansing composition of the present invention further includes components other than components used in ordinary cleansing agents, such as components (A), (B), (D), and (H), as long as the effects of the present invention are not impaired. Surfactants, moisturizers, oily components, anti-inflammatory agents, antiseptics, chelating agents, thickeners, salts, pearling agents, scrubbing agents, fragrances, cooling agents, pigments, ultraviolet absorbers, antioxidants, It can contain plant extracts and the like.

However, the content of the oily component is preferably 0 to 3% by mass, more preferably 0 to 2% by mass, and more preferably 0 to 1% by mass in the skin cleansing composition from the viewpoint of improving detergency and foaming. % By mass is more preferable, and 0 to 0.5% by mass is even more preferable. Here, the oily component is a hydrophobic substance that is phase-separated from water, and includes oils and fats, hydrocarbon oils, ester oils, higher alcohols, silicone oils, and the like.
The content of the surfactant other than the components (A), (B), (D) and (H) is preferably 5% by mass or less in the skin cleansing composition from the viewpoint of maintaining sterility. , Preferably 3% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less.

The skin cleansing composition of the present invention is produced by mixing the components according to a conventional method. The skin cleansing composition of the present invention is prepared by, for example, heating component (F) water to 50 to 90 ° C., preferably 60 to 80 ° C., sequentially mixing and dissolving each component, and stirring to dissolve at 40 ° C. or lower. , Preferably by cooling to a temperature range of 20 to 30 ° C.
Preferably, from the viewpoint of improving the solubility of the component (C), it is preferable that the component (C) is previously mixed with the component (B) and sufficiently dissolved.
Preferably, from the viewpoint of suppressing the volatilization of the component (E), it is preferable that the component (E) is added to a preparation obtained by mixing components other than the component (E) in a temperature range of 10 to 40 ° C. and mixed.
Preferably, the method for producing the skin cleansing composition of the present invention includes the following steps 1, 2 and 3.
Step 1: Add component (C) to component (B), mix and dissolve.
Step 2: The water of component (F) is heated to 60-80 ° C., and the components (A), (D), the preparation of step 1, and optionally components (G), (H) and (I) ) Is added.
Step 3: Cool the preparation of step 2 and, when cooled to 40 ° C., add component (E) and mix.
More preferably, step 4 includes a step of adjusting the pH to 3.0 to 6.0.

The pH of the skin cleansing composition of the present invention is preferably from 3.0 to 6.0, and more preferably from 3.5 to 5.5, from the viewpoint of improving bactericidal properties and suppressing irritation to the skin. Is more preferably 4.0 to 5.0.
In addition, pH measured each skin cleansing composition at 25 degreeC with the pH meter (The Horiba Seisakusho make: desktop-type pH and water-quality analyzer LAQUA F-72T). For the measurement, a 5% aqueous solution was prepared using ion-exchanged water, and the pH of the solution was measured. At this time, measurement is carried out with gentle stirring for 15 minutes until the value is stabilized, and a stable numerical value after stirring is measured.

The skin cleansing composition of the present invention can be preferably used as a skin cleansing composition filled in a container such as a pump former, a pump dispenser, a tube, a jar, and a squeeze dispenser.
When used by filling other than the former container, the viscosity at 30 ° C. is preferably 1000 mPa · s or more, and 2000 mPa · s, from the viewpoint of suppressing dripping from hands and improving ease of spreading the preparation. It is more preferably at least 2500 mPa · s, more preferably at most 9000 mPa · s, more preferably at most 7000 mPa · s, even more preferably at most 5,000 mPa · s. When used by filling other than a former container, the specific viscosity (30 ° C.) of the skin cleansing composition of the present invention is preferably 1,000 to 9000 mPa · s, more preferably 2000 to 7000 mPa · s, and 2,500 to 7000 mPa · s. 5000 mPa · s is more preferred.

The viscosity was measured by filling the skin cleansing composition into a container (standard bottle (with cap and packing) No. 11) such that about 100 g of air bubbles did not enter therein, and leaving it in a water bath set at 30 ° C. for about 1 hour. After adjusting the temperature, the viscosity is measured in 1 minute using a B-type viscometer / VISCOMMETER TVB-10M (manufactured by TOKI SANGYO CO., LTD) under the conditions of (i). If the measured value is within the accuracy range and a stable measured value is obtained, it is adopted as the measured value.However, the measured value is out of the accuracy range, or the measured value is stable because of the upper and lower limits of the accuracy range. If not, measure under the condition of (ii) Repeat this operation to obtain a stable measured value.
(I) No. M3: 12 rpm,
(Ii) No. M3: 30 rpm,
(Iii) No. M3: 6 rpm,
(Iv) No. M4: 12 rpm,
(V) No. M4: 30 rpm,
(Vi) No. M4: 6 rpm,
(Vii) No. M2: 12 rpm,
(Viii) No. M2: 30 rpm,
(Viiii) No. M2: 60 rpm,
(X) No. M1: 30 rpm,
(Xi) No. M1: 60 rpm,
(Xii) No. M2: 100 rpm

  When the skin cleansing composition of the present invention is used by filling it in a former container, the viscosity at 30 ° C. is preferably 150 mPa · s or less from the viewpoint of improving foam stability and foam fineness. , 100 mPa · s or less, more preferably 50 mPa · s or less, further preferably 1 mPa · s or more, more preferably 2 mPa · s or more, still more preferably 3 mPa · s or more. When used by filling in a former container, the specific viscosity (30 ° C.) of the skin cleansing composition of the present invention is preferably 1 to 150 mPa · s, more preferably 2 to 100 mPa · s, and more preferably 3 to 50 mPa.・ S is more preferred.

  INDUSTRIAL APPLICABILITY The skin cleansing composition of the present invention can be suitably used as a skin cleansing composition for disinfecting, in particular, because of its good bactericidal properties. As a specific dosage form, for example, it is suitable as a face wash, a body soap, a hand soap and the like, and a hand soap is more preferable.

The invention comprises the following components (A), (B), (C), (D) and (E):
(A) General formula (1)
R ¹ —O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average addition mole number, n represents a number of 0 to 3, and M represents an alkali metal, an alkaline earth metal, ammonium or Alkanol ammonium)
Anionic surfactant represented by 1.0 to 10% by mass,
(B) glyceryl ether having a hydrocarbon group having 4 to 22 carbon atoms, 0.5 to 5.0% by mass,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass;
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) 0.5 to 15% by mass of a saturated monohydric alcohol having 1 to 3 carbon atoms
A gram-positive bacterium and / or a gram-negative bacterium, wherein the composition has a mass ratio (B) / (E) of 0.10 to 5 for the component (B) to the component (E). A method for killing bacteria and / or gram-negative bacteria can be provided.

Examples of the Gram-positive bacteria and / or Gram-negative bacteria include, for example, Bacillus, Staphylococcus, Streptococcus, Lactobacillus, Clostridium, Listeria, Micrococcus, Propioni. Gram-positive bacteria such as bacterium; genus Escherichia, genus Pseudomonas, genus Enterobacter, genus Klebsiella, genus Citrobacter, genus Proteus, Serratia, Erwinia Erwinia), Vibrio, Acinetobacter, etc. Like ram-negative bacteria. In particular, it can exhibit an excellent bactericidal effect against one or two selected from bacteria belonging to Streptococcus aureus and Escherichia coli.
The term “sterilization” in the present invention means that a bactericidal activity value is 4 or more in a bactericidal test in Examples. The contact time of the composition of the present invention with the Gram-positive bacteria and / or Gram-negative bacteria is from 10 to 180 seconds, preferably from 10 to 60 seconds, and more preferably from 20 to 180 seconds, from the viewpoint of sufficiently exhibiting bactericidal properties. It can be 40 seconds.

With respect to the above-described embodiments, the present invention further discloses the following compositions.
<1> The following components (A), (B), (C), (D) and (E):
(A) General formula (1)
R ¹ —O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average addition mole number, n represents a number of 0 to 3, and M represents an alkali metal, an alkaline earth metal, ammonium or Alkanol ammonium)
Anionic surfactant represented by 1.0 to 10% by mass,
(B) glyceryl ether having a hydrocarbon group having 4 to 22 carbon atoms, 0.5 to 5.0% by mass,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass;
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) 0.5 to 15% by mass of a saturated monohydric alcohol having 1 to 3 carbon atoms
And a mass ratio (B) / (E) of the component (B) to the component (E) of 0.10 to 5 is provided.

<2> The component (A) is preferably polyoxyethylene (0) alkyl ether triethanolamine sulfate (triethanolamine alkyl sulfate), polyoxyethylene (0) alkyl ether ammonium sulfate (ammonium alkyl sulfate), polyoxyethylene ( 0) Sodium alkyl ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) triethanolamine sulfate alkyl ether, polyoxyethylene (1) ammonium ammonium sulfate alkyl, polyoxyethylene (2) ammonium ammonium sulfate alkyl, polyoxyethylene (2 ) Sodium alkyl ether sulfates comprising polyoxyethylene (1) alkyl ether triethanolamine sulfate and polyoxyethylene (1) alkyl ether sulfate ammonium Um and more preferably the <1> The skin cleansing composition.
<3> The content of the component (A) is preferably at least 1.3% by mass, more preferably at least 1.6% by mass, still more preferably at least 2.0% by mass, based on the total composition. The skin cleansing composition according to the above <1> or <2>, wherein the content is preferably at most 0.0% by mass, more preferably at most 5.0% by mass, and still more preferably at most 4.0% by mass.

<4> The component (B) preferably contains one or more kinds selected from glycerin mono-2-ethylhexyl ether, glycerin monoisodecyl ether and glycerin monoisostearyl ether. More preferably, it contains one or two selected from 2-ethylhexyl ether and glycerin monoisodecyl ether, and more preferably, it contains glycerin mono-2-ethylhexyl ether and glycerin monoisodecyl ether. The skin cleansing composition according to any one of <3>.
<5> The content of the component (B) is preferably 0.8% by mass or more in the entire composition, more preferably 1.0% by mass or more, still more preferably 1.5% by mass or more. The skin cleansing composition according to any one of <1> to <4>, wherein the skin cleansing composition is preferably 3.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 2.5% by mass or less.
<6> The content of the component (C) is preferably 0.02% by mass or more in the whole composition, more preferably 0.05% by mass or more, and preferably 0.5% by mass or less. The skin cleansing composition according to any one of <1> to <5>, more preferably 3% by mass or less.

<7> The alkyl glucoside of the component (D) is preferably a compound represented by the general formula (2):
R ^2- (OR ³ ) _m G _p (2)
(Wherein, R ² represents a straight-chain alkyl group having 8 to 16 carbon atoms, R ³ represents an alkylene group having 2 to 4 carbon atoms, G represents a group derived from a reducing sugar, and m represents an average addition mole. Represents a number, represents a number from 0 to 5, and p represents an average degree of condensation and represents a number from 1 to 3)
An alkyl glucoside represented by
Octyl polyglucoside, 2-ethylhexyl polyglucoside, decyl polyglucoside, lauryl polyglucoside, myristyl polyglucoside, palmityl polyglucoside, isostearyl polyglucoside, stearyl lauryl polyglucoside, and oleyl polyglucoside are more preferable. The skin cleanser composition according to any one of <1> to <3>.

<8> The content of the component (D) is preferably 0.8% by mass or more, more preferably 1.5% by mass or more, even more preferably 2.5% by mass or more in the whole composition. The skin cleansing composition according to any one of <1> to <7>, wherein the skin cleaning composition is preferably at most 0.0% by mass, more preferably at most 5.0% by mass, and still more preferably at most 4.5% by mass.
<9> The mass ratio (B) / (D) of the component (B) to the component (D) is preferably at least 0.30, more preferably at least 0.35, even more preferably at least 0.40. , 6 or less, preferably 4 or less, more preferably 2 or less, The skin cleansing composition according to any one of the above <1> to <8>.

<10> Component (E) is preferably methanol, ethanol, propanol, or isopropanol, more preferably ethyl alcohol and / or isopropanol, and further preferably contains ethanol. The skin cleansing composition according to any one of claims 1 to 4.
<11> The content of (E) is preferably 0.8% by mass or more in the entire composition, more preferably 1.0% by mass or more, still more preferably 2.0% by mass or more, and more preferably 10% by mass or more. % Or less, more preferably 7.0% by mass or less, and even more preferably 4.0% by mass or less. The skin cleansing composition according to any one of the above <1> to <10>.

<12> The mass ratio (B) / (E) of the component (B) to the component (E) is preferably 0.15 or more, more preferably 0.5 or more, and preferably 2 or less. The skin cleansing composition according to any one of <1> to <11>, wherein 5 or less is more preferable.
<13> The mass ratio (A) / (E) of the component (A) to the component (E) is preferably 0.05 or more, more preferably 0.1 or more, and still more preferably 0.3 or more. The skin cleansing composition according to any one of the above <1> to <12>, wherein the composition is preferably 5 or less, more preferably 3 or less, and still more preferably 1.5 or less.
<14> The mass ratio (E) / (D) of the component (E) to the component (D) is preferably 0.05 or more, more preferably 0.1 or more, and still more preferably 0.5 or more. The skin cleansing composition according to any one of the above <1> to <13>, preferably 5 or less, more preferably 3 or less, and still more preferably 1.5 or less.
<15> The water content of the component (F) is preferably from 60 to 95% by mass, more preferably from 65 to 90% by mass, and even more preferably from 70 to 85% by mass in the whole composition. > The skin cleansing composition according to any one of <14>.

<16> The skin cleansing composition according to any one of <1> to <15>, further comprising (G) a polyol.
be able to.
<17> Component (G) is preferably one or more selected from propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, 1,3-butylene glycol and sorbitol, and propylene glycol, polypropylene glycol One or more selected from glycerin and 1,3-butylene glycol is more preferable, and one or two or more selected from propylene glycol, polypropylene glycol and glycerin is further preferable, and at least glycerin is preferably contained. The skin cleansing composition according to <16>.
<18> The content of the component (G) is preferably 1% by mass or more in the entire composition, more preferably 3% by mass or more, still more preferably 5% by mass or more, and preferably 20% by mass or less, The skin cleansing composition according to the above <16> or <17>, more preferably 15% by mass or less, even more preferably 9% by mass or less.

<19> The skin cleansing composition according to any one of <1> to <18>, further comprising (H) polyoxyethylene alkyl ether carboxylic acid or a salt thereof.
<20> The polyoxyethylene alkyl ether carboxylic acid of the component (H) or a salt thereof is preferably a compound represented by the general formula (3):
R ⁴ —O— (CH ₂ CH ₂ O) _q —CH ₂ —COOX (3)
(Wherein, R ⁴ represents an alkyl group having ⁴ to 22 carbon atoms, q represents a number of 0 to 20, and X represents a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium or organic ammonium)
Which is represented by
Polyoxyethylene lauryl ether carboxylic acid or a salt thereof, polyoxyethylene myristyl ether carboxylic acid or a salt thereof, polyoxyethylene palmityl ether carboxylic acid or a salt thereof is more preferable, polyoxyethylene lauryl ether carboxylic acid or a salt thereof, and poly The skin cleansing according to <19>, further preferably containing one or two selected from oxyethylene myristyl ether carboxylic acid or a salt thereof, and still more preferably containing polyoxyethylene lauryl ether carboxylic acid or a salt thereof. Composition.
<21> The content of the component (H) is preferably 0.05% by mass or more in the entire composition, more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more. 0.0% by mass or less is preferable, 1.0% by mass or less is more preferable, and 0.7% by mass or less is further preferable. <19> or <20>.

<22> The skin cleansing composition according to any one of <1> to <21>, further comprising (I) cellulose to which a hydroxyethyl group or a hydroxypropyl group is added.
<23> Component (I) is preferably hydroxyethylcellulose, hydroxypropylcellulose, or hydroxypropylmethylcellulose having an average degree of substitution of 0.5 to 2, and an average molecular weight of 650,000 to 1,600,000. The skin cleansing composition according to <22>, which is more preferable.
<24> The content of the component (I) is preferably 0.1% by mass or more in the entire composition, more preferably 0.5% by mass or more, still more preferably 1% by mass or more, and 5% by mass. The skin cleansing composition according to <22> or <23>, wherein the content is preferably 3% by mass or less, more preferably 2% by mass or less.

<25> The content of the oily component is preferably 0 to 3% by mass in the skin cleansing composition, more preferably 0 to 2% by mass, still more preferably 0 to 1% by mass, and 0 to 0% by mass. The skin cleansing composition according to any one of the above <1> to <24>, wherein the content is more preferably 0.5% by mass.
<26> The content of the surfactant other than the components (A), (B), (D) and (H) is preferably 5% by mass or less in the skin cleansing composition, and 3% by mass. The skin cleansing composition according to any one of <1> to <25>, wherein the following is more preferred, the content is more preferably 1% by mass or less, and further more preferably 0.5% by mass or less.
<27> At 25 ° C., the pH is preferably 3.0 to 6.0, more preferably 3.5 to 5.5, and even more preferably 4.0 to 5.0. The skin cleanser composition according to any one of the above.

<28> The skin cleansing composition according to any one of <1> to <27>, which is preferably used by filling a container such as a pump former, a pump dispenser, a tube, a jar, and a squeeze dispenser.
<29> When used by filling other than the former container, the viscosity at 30 ° C. is preferably 1,000 mPa · s or more, more preferably 2000 mPa · s or more, still more preferably 2500 mPa · s or more, and 9000 mPa · s or less. , Preferably 7000 mPa · s or less, more preferably 5000 mPa · s or less, even more preferably 5,000 mPa · s or less.
<30> When used by filling into a former container, the viscosity at 30 ° C. is preferably 150 mPa · s or less, more preferably 100 mPa · s or less, further preferably 50 mPa · s or less, and 1 mPa · s or less. The skin cleansing composition according to <28>, wherein the composition is preferably at least 2 mPa · s, more preferably at least 3 mPa · s.

<31> The skin cleansing composition according to any one of <1> to <30>, which is preferably a skin cleansing composition for sterilization.
<32> Preferably, the method for producing a skin cleanser according to any one of <1> to <26>, including the following step 1, step 2, and step 3.
Step 1: Add component (C) to component (B), mix and dissolve.
Step 2: The water of component (F) is heated to 60-80 ° C., and the components (A), (D), the preparation of step 1, and optionally components (G), (H) and (I) ) Is added.
Step 3: Cool the preparation of step 2 and, when cooled to 40 ° C., add component (E) and mix.
More preferably, step 4 includes a step of adjusting the pH to 3.0 to 6.0.

Examples 1 to 11, Comparative Examples 1 to 6
Skin cleansing compositions having the compositions shown in Tables 1 and 2 were produced, and the cleansing properties, bactericidal properties, and foam quality were evaluated. The results are shown in Tables 1 and 2.

(Production method)
Step 1: Add component 3 (component (C)) to component 2 (component (B)), mix and dissolve.
Step 2: Component 12 (Component (F)) is heated to 70 ° C., and Component 1 (Component (A)), the preparation of Step 1, Components 4, 5 (Component (D)), Component 7 (Component (G) )), Component 8 (component (H)), components 9, 11, and 13 are added, and while mixing, component 10 is added so that the pH becomes 4.5.
Step 3: The preparation of Step 2 is cooled, and when cooled to 30 ° C., Component 6 (Component (E)) is added and mixed to obtain a skin cleansing composition.

(Evaluation method)
(1) Detergency:
20 μL of lard stain colored with carbon black was applied to a bioskin plate (manufactured by Beulux) within a range of Φ30 mm, and allowed to stand in a thermostat at 35 ° C. for 20 minutes. Using the measured value of the bioskin plate before applying the stain as an initial value, the color difference ΔE before washing was measured with a spectrophotometer (CM-600d, manufactured by Konica Minolta). Thereafter, massage was performed for 30 seconds with 1 mL of each composition, and rinsed with tap water (4 L / min) at 25 ° C. for 15 seconds. After drying sufficiently, the color difference ΔE after washing was measured, and the washing rate was calculated from the following equation. The average value of the cleaning rates at three locations was classified according to the following criteria.
Cleaning rate [%] = [1- (ΔE after cleaning) / (ΔE before cleaning)] * 100
A: 60% or more.
B: 50% or more and less than 60%.
C: less than 50%.

(2) Bactericidal properties:
Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used as test bacteria. As an inactivating solution, 38 g (powder) of SCDLP medium “Digo” (manufactured by Wako Pure Chemical Industries), 30 g of LP diluent (manufactured by “Digo” Wako Pure Chemical Industries) and ion-exchanged water were added to 1000 mL to increase the LP. SCDLP medium was prepared. A culture solution pre-cultured in an SCD medium (manufactured by Wako Pure Chemical Industries, Ltd.) was prepared in advance. 0.03 mL of the culture solution (3.3 to 9.9 × 10 ⁸ CFU / mL) was inoculated to 3 mL of each composition. After a certain time (30 seconds), 0.1 mL of the solution was inoculated into 0.9 mL of the inactivated solution. In addition, the same test was carried out for a sample using sterile ion-exchanged water instead of each composition as a control. A dilution series was prepared with sterile ion-exchanged water and plated on SCDLP agar medium (Becton Dickinson). The number of colonies that grew after incubation at 37 ° C. for 24 hours was counted, and the bactericidal activity value was calculated from the following equation. The average of three identical experiments was classified according to the following criteria.
Bactericidal activity value = LOG ((number of residual bacteria at the time of inoculating the composition) / (number of residual bacteria at the time of inoculating sterilized ion-exchanged water))
A: 4.5 or more.
B: 4 or more and less than 4.5.
C: less than 4.

(3) Foam quality:
Foam quality (fineness) was evaluated by three panelists. Panelists were instructed to perform the same hand-washing procedure for all compositions and did not disclose details of each composition. The sensory evaluation was performed on the fineness of the foam between 1 and 5. Assuming that the fine bubbles like cream are 5 and the state where no bubbles are formed is 1, the higher the value, the finer the bubbles. The average score of three persons was determined and classified according to the following criteria.
A: Average score of 4 or more.
B: Average score of 3 or more and less than 4.
C: Average score of less than 3.

Formulation Examples 1-29
A skin cleansing composition for sterilization having the composition shown in Table 3-5 was produced in the same manner as in the examples.
All of the obtained skin cleansing compositions were excellent in detergency, bactericidal property and foam quality.

Claims (6)

The following components (A), (B), (C), (D) and (E):
(A) General formula (1)
R ¹ —O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein, R ¹ represents a hydrocarbon group having 8 to 16 carbon atoms, n represents an average addition mole number, n represents a number of 0 to 3, and M represents an alkali metal, an alkaline earth metal, ammonium or Alkanol ammonium)
Anionic surfactant represented by 1.0 to 10% by mass,
(B) glyceryl ether having a hydrocarbon group having 4 to 22 carbon atoms, 0.5 to 5.0% by mass,
(C) at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol 0.01 to 0.8% by mass;
(D) alkyl glucoside 0.5 to 7.0% by mass,
(E) 0.5 to 15% by mass of a saturated monohydric alcohol having 1 to 3 carbon atoms
And a mass ratio (B) / (E) of the component (B) to the component (E) of 0.10 to 5 is provided.   The skin cleansing composition according to claim 1, wherein the mass ratio (B) / (D) of the component (B) to the component (D) is from 0.30 to 2.   The skin cleansing composition according to claim 1 or 2, further comprising (G) a polyol.   The skin cleansing composition according to any one of claims 1 to 3, further comprising (H) polyoxyethylene alkyl ether carboxylic acid or a salt thereof.   The skin cleansing composition according to any one of claims 1 to 4, wherein a mass ratio (A) / (E) of the component (A) to the component (E) is 0.05 to 5.   The skin cleansing composition according to any one of claims 1 to 5, further comprising (I) cellulose to which a hydroxyethyl group or a hydroxypropyl group is added.