CN112791026B - Antibacterial hand sanitizer and preparation method thereof - Google Patents

Abstract

The application relates to the technical field of washing and caring articles, and particularly discloses an antibacterial hand sanitizer and a preparation method thereof. The technical points are as follows: an antibacterial hand sanitizer comprises the following components in percentage by weight: 0.1-0.5% of plant extract, 0.05-0.2% of allantoin, 1-2% of propylene glycol, 10-20% of surfactant, 0.5-1.5% of foam booster, 0.1-1% of viscosity regulator, 0.01-0.05% of bactericide, 0.01-0.05% of preservative, 0.05-0.15% of essence and the balance of deionized water. The antibacterial hand sanitizer prepared by the application has the advantages of good decontamination effect, excellent antibacterial and bacteriostatic properties and no harm to human bodies and environment.

Description

Antibacterial hand sanitizer and preparation method thereof

Technical Field

The application relates to the technical field of washing and caring articles, in particular to an antibacterial hand sanitizer and a preparation method thereof.

Background

At present, the hand sanitizer is a skin care cleansing liquid mainly for cleaning hands, and bacteria on the hands are removed through the action of a surfactant and mechanical friction. The hand sanitizer comprises common hand sanitizer, foam hand sanitizer, common/foam bacteriostatic hand sanitizer and the like, is mainly water-based hand sanitizer added with surfactant, and can generate bubbles in the cleaning process; there is another class of no-clean hand sanitizers, which are gel no-clean hand sanitizers consisting essentially of 75% alcohol, which clean without lather.

Most of the antibacterial effects of hand sanitizers result from the preservatives contained therein, and abuse of chemical preservatives in daily chemical products can cause damage to the skin and health of people. The high-concentration triclosan, sanfoban and nipagin ester chemical preservative can interfere internal secretion of human bodies, even cause cancer and cause harm to human health. In addition, the washed preservative wastewater is not easy to degrade, has great harm to aquatic organisms and is not beneficial to environmental protection.

In view of the above-mentioned related art, the inventors consider that the hand sanitizer in the existing market contains a high proportion of industrial preservatives, resulting in adverse effects on human health and environmental protection.

Disclosure of Invention

In order to improve the health effect and environmental protection of the hand sanitizer, the application provides an antibacterial hand sanitizer and a preparation method thereof.

In a first aspect, the application provides an antibacterial hand sanitizer, which adopts the following technical scheme:

an antibacterial hand sanitizer comprises 0.1-0.5 wt% of plant extract, wherein the plant extract is a mixture of grapefruit extract and peony root extract, and the weight ratio of the grapefruit extract to the peony root extract is (1) - (4).

By adopting the technical scheme, the naringin contained in the grapefruit extract has the functions of resisting inflammation, easing pain, resisting virus, inhibiting bacteria and inhibiting aldose reductase, and the grapefruit extract not only has higher antibacterial activity on staphylococcus aureus, escherichia coli and typhoid bacillus, but also is a strong broad-spectrum antifungal medicine. The collagen fiber gel contained in the peony root extract has the effects of resisting bacteria and diminishing inflammation, tranquilizing and relieving pain, clearing heat and removing blood stasis and the like, and also has a preservative function. The two plant extracts are compounded for use, have a certain synergistic effect, have better antibacterial and bacteriostatic effects, have the effects of calming, easing pain and diminishing inflammation, are also suitable for skin with wounds, are mild and not irritant, and have good using effects.

More preferably, the weight ratio of the grapefruit extract to the peony root extract is 1.

By adopting the technical scheme, the weight ratio of the grapefruit extract to the peony root extract is controlled to be 1.

Further preferably, the antibacterial hand sanitizer further comprises the following components in percentage by weight: 0.05-0.2% of allantoin, 1-2% of propylene glycol, 10-20% of surfactant, 0.5-1.5% of foam booster, 0.1-1% of viscosity regulator, 0.01-0.05% of bactericide, 0.01-0.05% of preservative, 0.05-0.15% of essence and the balance of deionized water.

By adopting the technical scheme, the allantoin can directly act on the stratum corneum to increase and promote the hydration capability of the stratum corneum, namely enhance the water binding capability of the stratum corneum, thereby reducing water loss, enabling the skin to be smooth, moist and elastic, and relieving, treating and moistening the skin. The propylene glycol is a good micromolecular skin humectant, can retain water in the skin cuticle, is used together with allantoin, and can endow the hand sanitizer with a good moisturizing effect. According to the hand sanitizer, the bactericide and the preservative are mainly used as base materials, the natural plant extract with good antibacterial and bacteriostatic effects is added, the using amount of the bactericide and the preservative is reduced, a small amount of chemical synthetic raw materials and natural herbaceous plant raw materials are combined, the characteristics and advantages of various functional raw materials are brought into play, the antibacterial and the preservative are synergistically exerted, and the allantoin and the propylene glycol are compounded for use, so that the hand sanitizer is mild in use, high in stability and has a moisturizing effect on skin.

More preferably, the antibacterial hand sanitizer also comprises 0.05-0.15% by weight of citric acid.

By adopting the technical scheme, the citric acid belongs to organic acid, has the effects of descaling and sterilizing when added into the hand sanitizer, can prolong the continuous antibacterial effect of the hand sanitizer, has the function of increasing aroma and improves the quality of the hand sanitizer.

More preferably, the antibacterial hand sanitizer comprises the following components in percentage by weight: 0.4% of plant extract, 0.14% of allantoin, 1.6% of propylene glycol, 15.4% of surfactant, 1.1% of foam booster, 0.4% of viscosity regulator, 0.04% of bactericide, 0.03% of preservative, 0.11% of essence and 80.78% of deionized water.

By adopting the technical scheme, the raw material components are in the optimal proportion, and the antibacterial hand sanitizer obtained by the raw material components and the proportion has good antibacterial and bacteriostatic effects, is mild and non-irritant, and is harmless to the environment.

Further preferably, the surfactant is a mixture of cocamidopropyl betaine and sodium laureth sulfate, and the weight ratio of the cocamidopropyl betaine to the sodium laureth sulfate is 1 (1-1.2).

By adopting the technical scheme, the cocoamidopropyl betaine is a zwitterionic surfactant and has good stability under acidic and alkaline conditions, the sodium laureth sulfate is an anionic surfactant with excellent performance, and the two are compounded according to the proportion, so that the hand sanitizer has good thickening property and foaming capacity, and has a decontamination and descaling effect.

Further preferably, cocamide DEA is used as the foam booster, and sodium chloride is used as the viscosity regulator.

Through adopting above-mentioned technical scheme, coconut oil amide EDA can play increases the effect of running, improves the whole decontamination of liquid soap, bactericidal effect, reduces the quantity of liquid soap, and ammonium chloride can play the effect of adjusting the liquid soap viscosity, can also play the effect of adjusting liquid soap pH with the citric acid cooperation.

More preferably, the bactericide is trichlorohydroxydiphenyl ether, and the preservative is a mixture of methylchloroisothiazolinone and methylisothiazolinone, magnesium chloride and magnesium nitrate.

By adopting the technical scheme, the triclosan is a broad-spectrum antibacterial agent, is widely applied to daily chemicals such as soap, toothpaste and the like, has an antibacterial effect, a certain anti-inflammatory effect and a certain deodorization effect, is used for disinfecting the surface of an object in daily life, can act on the cell wall of microorganisms, destroys the permeability of the cell wall, enables the cell content to flow out greatly, permeates harmful substances greatly, enables the microorganisms to die, has a strong killing effect on bacterial propagules, has a strong effect on more negative bacteria of gram-positive bacteria, has an obvious killing effect on fungi, and is suitable for disinfecting the surfaces of skin, mucous membranes, articles and the like. The mixture of methyl chloroisothiazolinone, methyl isothiazolinone, magnesium chloride and magnesium nitrate is one excellent antiseptic, and has broad spectrum, high efficiency, capacity of deactivating bacteria, fungi and other microbes and algae, wide application range, high compatibility, capacity of being compatible with cationic and anionic surfactants, low use concentration, fast acting, long lasting period, high permeating capacity, convenient use, low cost, wide temperature and pH limit, environment friendship, capacity of degrading into non-toxic matter and no environmental pollution.

In a second aspect, the application provides a preparation method of an antibacterial hand sanitizer, which adopts the following technical scheme:

the preparation method of the antibacterial hand sanitizer is characterized by comprising the following steps of:

s1, mixing and dissolving trichloro hydroxyl diphenyl ether and propylene glycol for later use;

s2, mixing and heating deionized water and sodium laureth sulfate to 80-85 ℃, and uniformly stirring and dissolving;

s3, sequentially adding cocamidopropyl betaine, cocamide DEA and allantoin, and stirring to dissolve uniformly;

s4, cooling to 60-65 ℃, adding premixed trichloro hydroxyl diphenyl ether and propylene glycol, and stirring to dissolve uniformly;

s5, continuously cooling to 40-45 ℃, sequentially adding citric acid and sodium chloride, and uniformly stirring and dissolving;

s6, adding essence, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate, and the plant extract, and stirring and mixing uniformly;

s7, cooling to 35-38 ℃, and standing for 8-12h to obtain the product.

By adopting the technical scheme, the operation is simple, the production efficiency is high, more complex equipment is not needed, the method is suitable for large-scale production, higher conditions such as heating and pressurizing are not involved in the production process, and the preparation conditions are mild.

In summary, the present application has the following beneficial effects:

(1) According to the antibacterial and bacteriostatic composite, trichlorohydroxydiphenyl ether, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate and plant extracts are used as antibacterial effective raw materials, and chemical synthetic raw materials and natural herbaceous plant raw materials are combined to play the characteristics and advantages of the effective raw materials, so that the synergistic antibacterial and preservative effects are achieved;

(2) According to the application, the plant extract with the antibacterial effect is added, so that the use of chemical synthesis raw materials is reduced, and the allantoin and the humectant are added, so that the prepared hand sanitizer has the advantages of being mild and having a moisturizing effect on skin;

(3) The application provides a preparation method of the antibacterial hand sanitizer, which does not involve conditions with higher requirements such as heating and warming, is simple to operate, has high preparation efficiency, and is suitable for industrial large-scale production.

Detailed Description

The present application will be described in further detail with reference to examples.

Some of the raw material sources in the examples and comparative examples of the present application are shown in table 1 below:

TABLE 1 sources of the raw Material Components

Raw material components	Source
		Grapefruit extract	Shanghai Laibo Biotechnology Co., Ltd.
Peony root extract	Shanghai Laibo Biotechnology Co., Ltd.
		Allantoin	SHANDONG AILITONG NEW MATERIALS Co.,Ltd.
Methyl chloro isothiazolinone and methyl isothiazolinone with chlorine	Shanghai Sangdi Fine chemical Co., ltd
		Essence (Green essence)	GUANGDONG WINCOM FLAVORS & FRAGRANCES Co.,Ltd.

Examples

Example 1

The antibacterial hand sanitizer comprises the components and the corresponding weight shown in the table 2, and is prepared by the following steps:

s1, mixing and dissolving trichloro hydroxyl diphenyl ether and propylene glycol for later use;

s2, mixing and heating deionized water and sodium laureth sulfate to 80 ℃, stirring at the rotating speed of 80rpm for 30min, and dissolving uniformly;

s3, sequentially adding cocamidopropyl betaine, cocamide DEA and allantoin, continuously stirring at the rotating speed of 80rpm for 15min, and uniformly dissolving;

s4, cooling to 60 ℃, adding the premixed trichloro hydroxyl diphenyl ether and propylene glycol, continuously stirring at the rotating speed of 80rpm for 5min, and uniformly dissolving;

s5, continuously cooling to 40 ℃, adding sodium chloride, continuously stirring for 5min at the rotating speed of 80rpm, and uniformly stirring and dissolving;

s6, adding essence, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate, and the plant extract, continuously stirring at the rotating speed of 80rpm for 15min, and uniformly stirring and mixing;

s7, cooling to 35 ℃, and standing for 12 hours to obtain the product.

Examples 2 to 6

An antibacterial hand sanitizer which is different from that of example 1 in that components and corresponding weights thereof are shown in table 2.

TABLE 2 Components and weights (kg) thereof in examples 1-6

Example 7

The antibacterial hand sanitizer is prepared from the following components in parts by weight as shown in Table 2:

s1, mixing and dissolving trichloro hydroxyl diphenyl ether and propylene glycol for later use;

s2, mixing and heating deionized water and sodium laureth sulfate to 85 ℃, stirring at the rotating speed of 60rpm for 30min, and dissolving uniformly;

s3, sequentially adding cocamidopropyl betaine, cocamide DEA and allantoin, continuously stirring at the rotating speed of 60rpm for 15min, and uniformly dissolving;

s4, cooling to 65 ℃, adding premixed trichloro hydroxyl diphenyl ether and propylene glycol, continuously stirring at the rotating speed of 60rpm for 5min, and uniformly dissolving;

s5, continuously cooling to 45 ℃, adding sodium chloride, continuously stirring for 5min at the rotating speed of 60rpm, and uniformly stirring and dissolving;

s6, adding essence, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate, and the plant extract, continuously stirring at the rotating speed of 60rpm for 15min, and uniformly stirring and mixing;

s7, cooling to 38 ℃, and standing for 8 hours to obtain the product.

Example 8

An antibacterial hand sanitizer is different from embodiment 1 in that 0.05kg of citric acid is added in step S5, and the specific operation steps are as follows:

and S5, continuously cooling to 40 ℃, sequentially adding citric acid and sodium chloride, continuously stirring at the rotating speed of 80rpm for 10min, and uniformly stirring and dissolving.

The remaining steps were the same as in example 1.

Example 9

An antibacterial hand sanitizer is different from embodiment 1 in that 0.1kg of citric acid is added in step S5, and the specific operation steps are as follows:

and S5, continuously cooling to 40 ℃, sequentially adding citric acid and sodium chloride, continuously stirring at the rotating speed of 80rpm for 10min, and uniformly stirring and dissolving.

The remaining steps were the same as in example 1.

Example 10

An antibacterial hand sanitizer is different from embodiment 1 in that 0.15kg of citric acid is added in step S5, and the specific operation steps are as follows:

and S5, continuously cooling to 40 ℃, sequentially adding citric acid and sodium chloride, continuously stirring at the rotating speed of 80rpm for 10min, and uniformly stirring and dissolving.

The remaining steps were the same as in example 1.

Comparative example

Comparative example 1

An antibacterial hand sanitizer, which is different from example 1 in that the same weight of grapefruit extract is used instead of the peony root extract.

Comparative example 2

An antibacterial hand sanitizer which is different from that of example 1 in that the same weight of a peony root extract is used instead of a grapefruit extract.

Comparative example 3

An antibacterial hand sanitizer which is different from that in example 1 in that deionized water with the same weight is used for replacing plant extracts.

Comparative example 4

An antibacterial hand sanitizer, which is different from the antibacterial hand sanitizer in example 1, is prepared by replacing a bactericide with deionized water in the same weight.

Comparative example 5

An antibacterial hand sanitizer which is different from that in example 1 in that deionized water with the same weight is used instead of a preservative.

Comparative example 6

An antibacterial hand sanitizer which is different from that in example 1 in that deionized water with the same weight is used for replacing a bactericide and a preservative.

Performance test

The antibacterial hand sanitizer prepared in examples 1 to 10 and comparative examples 1 to 6 were tested for antibacterial performance.

The detection method is based on: GB15979-2002 hygienic Standard for Disposable sanitary articles-appendix C method for testing the sterilization performance, the bacteriostatic performance and the stability of products;

evaluation basis: GB15979-2002 hygienic Standard for disposable articles.

The test results are shown in table 3 below.

As can be seen from the test data in table 3, the antibacterial hand sanitizer prepared in examples 1 to 10 has a bacteriostasis rate to escherichia coli, staphylococcus aureus and candida albicans, and the action time can reach 100% after reaching more than 5min, which indicates that the hand sanitizer prepared in the present application has a good antibacterial effect. In addition, the hand sanitizer formula does not contain preservatives which have irritation to skin, the addition amount of bactericides and the like except plant extracts is far lower than that of the common antibacterial hand sanitizer, and the hand sanitizer is harmless to human bodies and the environment.

The test results of the example 1 and the comparative examples 1 to 3 show that the grapefruit extract and the peony root extract both have certain bacteriostatic effects, but the effects of the two extracts are not good when the two extracts are used independently, and after the two extracts are compounded according to the formula proportion, the bacteriostatic rate is obviously improved, so that the grapefruit extract and the peony root extract have certain synergistic effect when the grapefruit extract and the peony root extract are compounded.

According to the test results of the embodiment 1 and the comparative examples 4 to 6, the bacteriostatic effect of the hand sanitizer is improved to a certain extent by a small amount of the bactericide and the preservative, and even if the addition amount of the bactericide and the preservative is lower than that of the conventional commercially available hand sanitizer, the hand sanitizer still has a good bacteriostatic rate under the condition of compounding the plant extract.

Table 3 results of performance testing

The above description is only a preferred embodiment of the present application, and the scope of the present application is not limited to the above embodiments, and all technical solutions belonging to the idea of the present application belong to the scope of the present application. It should be noted that several improvements and modifications to the present application without departing from the principles of the present application will occur to those skilled in the art, and such improvements and modifications should also be considered within the scope of the present application.

Claims (3)

1. An antibacterial hand sanitizer is characterized by comprising 0.1% by weight of plant extracts, wherein the plant extracts are a mixture of grapefruit extracts and peony root extracts, and the weight ratio of the grapefruit extracts to the peony root extracts is 1;

the antibacterial hand sanitizer also comprises the following components in percentage by weight: 0.05% of allantoin, 1% of propylene glycol, 10% of surfactant, 0.5% of foam booster, 0.1% of viscosity regulator, 0.01% of bactericide, 0.01% of preservative, 0.05% of essence and the balance of deionized water;

the surfactant is a mixture consisting of cocamidopropyl betaine and sodium laureth sulfate, and the weight ratio of the cocamidopropyl betaine to the sodium laureth sulfate is 1;

the foaming agent adopts cocamide DEA, the viscosity regulator adopts sodium chloride, the bactericide adopts trichlorohydroxydiphenyl ether, and the preservative adopts a mixture of methylchloroisothiazolinone, methylisothiazolinone, magnesium chloride and magnesium nitrate.

2. The antimicrobial hand sanitizer according to claim 1, further comprising citric acid in an amount of 0.05 to 0.15% by weight.

3. A process for preparing an antibacterial hand sanitizer according to any one of claims 1 to 2, comprising the steps of:

s1, mixing and dissolving trichloro hydroxyl diphenyl ether and propylene glycol for later use;

s2, mixing and heating deionized water and sodium laureth sulfate to 80-85 ℃, and uniformly stirring and dissolving;

s3, sequentially adding cocamidopropyl betaine, cocamide DEA and allantoin, and stirring to dissolve uniformly;

s4, cooling to 60-65 ℃, adding premixed trichloro hydroxyl diphenyl ether and propylene glycol, and stirring to dissolve uniformly;

s5, continuously cooling to 40-45 ℃, sequentially adding citric acid and sodium chloride, and uniformly stirring and dissolving;

s6, adding essence, methyl chloroisothiazolinone, a mixture of methyl isothiazolinone, magnesium chloride and magnesium nitrate, and the plant extract, and stirring and mixing uniformly;

s7, cooling to 35-38 ℃, and standing for 8-12 hours to obtain the product.