CN111888374A - Microbial killing composition and preparation method thereof - Google Patents
Microbial killing composition and preparation method thereof Download PDFInfo
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- CN111888374A CN111888374A CN202010819092.1A CN202010819092A CN111888374A CN 111888374 A CN111888374 A CN 111888374A CN 202010819092 A CN202010819092 A CN 202010819092A CN 111888374 A CN111888374 A CN 111888374A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Abstract
The invention discloses a microbial sterilizing composition and a preparation method thereof, wherein the composition comprises a guanidine disinfectant, a cationic surfactant, an auxiliary emollient, a foaming agent, a pH regulator and the like, but does not contain ethanol. The composition has good sterilization effect on pyococcus, intestinal pathogenic bacteria, pathogenic yeast, hospital infection common bacteria and the like, and also has a killing effect on enveloped coronavirus.
Description
Technical Field
The invention belongs to the technical field of microbial killing, and particularly relates to a microbial killing composition and a preparation method thereof.
Background
Currently, there are no exact effective therapeutic drugs and vaccines against the new coronavirus of 2019. The treatment is mainly to support symptomatic and moderate suppression immunity. How to effectively block the transmission of viruses and establishing daily protection consciousness is a very effective preventive measure. An antiviral microbial killing composition can effectively block or reduce the risk of contact transmission and has important significance in protecting the health of people.
The disinfectant is mainly a composition of alcohols, disinfectant, surfactant, foaming agent, etc. The common disinfectant is guanidine disinfectant, and has stable property, good sterilizing effect and low irritation. In the prior art, chlorhexidine acetate and ethanol are used in a matching way, for example, the foam disinfectant disclosed by the invention patent with the application publication number of CN105456548A and the preparation process thereof, and the foam disinfectant comprises 0.05-0.5% of chlorhexidine acetate, 8-15% of glycerol, 50-75% of ethanol, 0.1-2% of cocobetaine and the like. Patent publications WO/2004/018003 (ALDAPHARMACEUTICAL CORP.), WO/1995/012395 (E.R. SQUIBB AND SONS, INC.) disclose the use of chlorhexidine gluconate for disinfection AND sterilization. In the prior art, didecyl ammonium dichloride and ethanol are used in combination. The invention discloses a skin disinfectant disclosed in the patent publication No. CN104337802A, which comprises 1-5 parts of didecylammonium dichloride, 2-10 parts of isopropyl myristate, 40-60 parts of ethanol, 1-2 parts of chlorhexidine, 2-4 parts of isopropanol and 50-80 parts of water. In addition, numerous patents have disclosed the use of didecylammonium dichloride for disinfection and sterilization, such as CN101492632B, CN1425286A, and the like.
In the prior art, chlorhexidine gluconate and didecyl ammonium dichloride are used together with ethanol, and although the bactericidal composition has a good bactericidal effect, the bactericidal composition also has the following obvious defects: 1. due to the strong volatility of ethanol, it does not provide sustained protection for long periods of time. 2. Has obvious irritation and is not beneficial to the long-term or frequent use of naked skin. 3. Ethanol has great potential safety hazard and is easy to cause fire or explosion.
A plurality of novel coronavirus pneumonia diagnosis and treatment schemes released in the country at present clearly indicate that chlorhexidine cannot inactivate viruses. Surprisingly, in the research process, the guanidine disinfectant and the cationic surfactant are combined for use, and the invention is surprisingly found that the guanidine disinfectant has stronger bactericidal capability and has a killing effect on human coronavirus even if the guanidine disinfectant and the cationic surfactant are not matched for use, thereby completing the invention.
Disclosure of Invention
The invention aims to provide a microbial sterilizing composition and a preparation method thereof, and the composition not only overcomes the defect of the prior art that the disinfectant has a virus killing effect, but also overcomes the obvious defects of irritation, safety and the like of ethanol in the prior art.
The invention relates to a microbial sterilizing composition, which comprises a guanidine disinfectant and a cationic surfactant, but does not contain ethanol.
The disinfectant composition of the present invention further comprises one or more of an emollient, a foaming agent and a pH adjusting agent
The guanidine disinfectant is selected from one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof;
the disinfecting composition, wherein the cationic surfactant is one or more selected from didecyl ammonium dichloride or a derivative thereof, benzalkonium chloride and benzalkonium bromide; the emollient is selected from one or more of propylene glycol, glycerol and glycerol polyoxyethylene ether;
the foaming agent is selected from one or more of undecyl formamide propyl trimethyl ammonium sulfate, cocamidopropyl betaine and fatty amidopropyl amine oxide; the pH regulator is selected from one or more of lactic acid, citric acid, tartaric acid and malic acid,
the pH value is 4.0-6.0.
In one embodiment, preferably, the present invention provides a biocidal composition comprising:
more preferably, the present invention provides a biocidal composition comprising:
in the above preferred embodiment, the appropriate amount of the pH regulator is an amount to adjust the pH of the composition to 4.0-6.0.
The present invention also provides a method of preparing the microbial microbiocidal composition of the present invention, comprising the steps of:
(1) adding water soluble emollient 90-95 wt% of the total amount of the above components, and stirring to dissolve completely;
(2) adding a guanidine disinfectant and a cationic surfactant into the mixed solution obtained in the step (1), and stirring until the guanidine disinfectant and the cationic surfactant are completely dissolved;
(3) adding a foaming agent into the mixed solution obtained in the step (2), and stirring until the foaming agent is completely dissolved;
(4) and (4) adding the residual amount of water into the step (3), mixing, and adding a pH regulator to regulate the pH of the mixed solution to 4.0-6.0 to obtain the water-soluble organic silicon dioxide.
The invention also provides the application of the microbial sterilizing composition in the preparation of medicaments for killing and controlling pyogenic cocci, intestinal pathogenic bacteria, pathogenic yeast and common bacteria infected in hospitals.
The invention also provides the application of the microbial sterilizing composition in the preparation of medicaments for killing and preventing human coronavirus, rotavirus, coronavirus and the like with similar structures.
In a specific embodiment, the present invention provides a microbial disinfectant composition comprising the following components in percentage by weight:
in the above embodiments, the microbial disinfectant composition of the present invention, preferably, the guanidine disinfectant is one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof, preferably chlorhexidine gluconate;
preferably, the cationic surfactant is one or more of didecyl ammonium dichloride and derivatives thereof, benzalkonium chloride and benzalkonium bromide, and is preferably didecyl ammonium dichloride;
preferably, the emollient is one or more of propylene glycol, glycerol and glycerol polyoxyethylene ether, and is preferably propylene glycol;
preferably, the foaming agent is one or more of undecyl formamide propyl trimethyl ammonium sulfate, cocamidopropyl betaine and fatty amide propyl amine oxide, and the foaming agent is preferably undecyl formamide propyl trimethyl ammonium sulfate;
preferably, the pH regulator of the composition is lactic acid and has a pH value of 4.0-6.0.
Compared with the prior art, the microbial sterilizing composition has the following advantages:
(1) the hand drying agent adopts purified water as a solvent, does not contain ethanol, has the characteristics of mildness and no stimulation, has better use tolerance and safety, and has higher drying speed and more comfortable and comfortable hand after drying. The microbial sterilizing composition contains an emollient, can protect hands of medical workers, and can prevent hand dryness or chapping caused by frequent use;
(2) the preparation method of the microbial sterilizing composition is simple and easy to operate, and the production cost is low. The guanidine disinfectant is adopted, so that the solubility of the guanidine disinfectant in water is high, the application range is wide, the disinfection effect and the bacteriostatic effect are strong under low concentration, the bacteriostatic time is long, and the effective bactericidal time can be prolonged;
(3) the guanidine disinfectant is matched with the cationic surfactant for use, and even if the guanidine disinfectant is not matched with ethanol for use, the guanidine disinfectant has a good effect of killing bacteria and viruses. The disinfectant can kill Escherichia coli, Staphylococcus aureus, and Candida albicans within 1min, and human coronavirus within 3min, and has high sterilizing speed and effect in killing human coronavirus compared with disinfectant in the prior art.
The specific implementation mode is as follows:
the present invention will be further described with reference to the following examples.
Example 1
The microbial sterilizing composition comprises the following components in percentage by weight:
the guanidine disinfectant is chlorhexidine gluconate. The chlorhexidine gluconate is added in the form of a chlorhexidine gluconate aqueous solution. The mass concentration of the chlorhexidine gluconate in the chlorhexidine gluconate water solution is 18.2 percent.
The cationic surfactant is didecylammonium dichloride. Didecylammonium dichloride was added as an aqueous solution of didecylammonium dichloride. The mass concentration of didecyl ammonium dichloride in the aqueous solution of didecyl ammonium dichloride is 80.1%.
The emollient is propylene glycol.
The foaming agent is undecyl formamide propyl trimethyl ammonium sulfate.
The pH regulator is lactic acid, and the pH value is 5.15.
The method for preparing the microbial sterilizing composition of the embodiment comprises the following steps:
(1) firstly, adding water which is 90-95% of the total amount of all the components to dissolve propylene glycol, and stirring until the propylene glycol is completely dissolved;
(2) adding chlorhexidine gluconate and didecylammonium dichloride into the mixed solution obtained in the step (1), and stirring until the chlorhexidine gluconate and the didecylammonium dichloride are completely dissolved;
(3) adding undecylformamide propyl trimethyl ammonium sulfate into the mixed solution obtained in the step (2), and stirring until the mixture is completely dissolved;
(4) and (4) adding the residual amount of water into the step (3), and adjusting the pH of the obtained mixed solution to 4.0-6.0 by adopting lactic acid to obtain the microbial sterilizing composition.
Example 2
The microbial sterilizing composition comprises the following components in percentage by weight:
the guanidine disinfectant is chlorhexidine gluconate. The chlorhexidine gluconate is added in the form of a chlorhexidine gluconate aqueous solution. The mass concentration of the chlorhexidine gluconate in the chlorhexidine gluconate water solution is 18.2 percent.
The cationic surfactant is didecylammonium dichloride. Didecylammonium dichloride was added as an aqueous solution of didecylammonium dichloride. The mass concentration of didecyl ammonium dichloride in the aqueous solution of didecyl ammonium dichloride is 80.1%.
The emollient is propylene glycol.
The foaming agent is undecyl formamide propyl trimethyl ammonium sulfate.
The pH regulator is lactic acid, and the pH value is 4.18.
The microbial disinfectant composition of this example was prepared in the same manner as in example 1
The guanidine disinfectant is chlorhexidine gluconate. The chlorhexidine gluconate is added in the form of a chlorhexidine gluconate aqueous solution. The mass concentration of the chlorhexidine gluconate in the chlorhexidine gluconate water solution is 18.2 percent.
The cationic surfactant is didecylammonium dichloride. Didecylammonium dichloride was added as an aqueous solution of didecylammonium dichloride. The mass concentration of didecyl ammonium dichloride in the aqueous solution of didecyl ammonium dichloride is 80.1%.
The emollient is propylene glycol.
The foaming agent is undecyl formamide propyl trimethyl ammonium sulfate.
The pH regulator is lactic acid, and the pH value is 5.88.
The microbial disinfectant composition of this example was prepared in the same manner as in example 1
Test example 1: sterilization test of the composition of the present invention
The bactericidal effect of the microbial sterilizing composition prepared by the three embodiments of the invention is determined according to the test method specified in GB/15979-.
Preparing a bacterial suspension: respectively diluting staphylococcus aureus, escherichia coli and candida albicans cultured for 24h into bacterial suspensions by using 0.03mol/L phosphate buffer solution.
Quantitative sterilization test of bacterial suspension: 5.0mL of each of the compositions of examples 1-3 were placed in a sterile tube, and 100. mu.L of each bacterial suspension was added to the tube and vortexed to mix the suspension. Acting for 1min, respectively adding 1mL of the mixed solution into a sterile test tube containing 5mL of neutralizer, and mixing. And (3) after neutralization for 10min, taking 1.0mL of the mixed solution, inoculating a sterile plate, pouring a common nutrient agar culture medium, culturing for 48h (staphylococcus aureus and escherichia coli) and 72h (candida albicans) in a 37 ℃ incubator, counting the number of plate colonies, averaging the experiments for three times, taking an average value, and calculating the sterilization rate. The test results are shown in table 1.
TABLE 1 fungicidal Effect of the compositions
As can be seen from Table 1, the composition of the present invention can kill Staphylococcus aureus, Escherichia coli and Candida albicans within 1 min. Has high bactericidal rate and quick sterilization, and is suitable for preventing and controlling pyogenic coccus, intestinal pathogenic bacteria, pathogenic yeast, hospital infection common bacteria, and the like.
Test example 2: virus killing assay for compositions of the invention
The virus-killing effect of the microbial disinfectant compositions prepared in the three embodiments of the present invention was determined according to the test methods of GB/15979-2002, items 2.1.1.10.5 and 2.1.1.10.7, and the selected virus was human coronavirus ATCC®VR740229E。
Preparation of virus suspension: will 106TCID50/0.1mL~107TCID500.1mL HCoV-229E virus suspension and organic interferent are subjected to double dilution to prepare virus suspension for test, and the virus suspension is placed in a thermostat at 20 ℃ for 5min for later use.
Virus suspension quantitative inactivation test: 0.8mL of each of the compositions of examples 1-3 was added to a sterile tube, and 0.2mL of each of the virus suspensions was added to the tube and mixed. Acting for 3.0min, respectively adding 0.1mL of the mixed solution into a sterile test tube containing 0.9mL of neutralizer, and mixing uniformly. And (3) properly diluting the cell maintenance solution, sucking the sample solution, inoculating the sample solution on a monolayer cell culture plate, culturing the cell culture plate in a titanium dioxide box at 37 ℃ for 3d, calculating the virus titer value, averaging the experiments for three times, taking the average value, and calculating the inactivation logarithm value. The test results are shown in Table 2
TABLE 2 Virus-killing Effect of the compositions
As can be seen from Table 2, the composition of the present invention can kill human coronavirus within 3 min. Has good killing effect, and is suitable for preventing and controlling human coronavirus, rotavirus, coronavirus envelope and other viruses with similar structures.
Claims (13)
1. A microbial disinfectant composition comprising a guanidine disinfectant and a cationic surfactant, but no ethanol.
2. A biocidal composition according to claim 1 further comprising one or more of emollients, sudsing agents and pH modifiers.
3. A disinfecting composition as claimed in claim 1 or claim 2, wherein the guanidine disinfectant is selected from one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof.
4. A disinfecting composition according to claim 1 or claim 2 wherein the cationic surfactant is selected from one or more of didecylammonium dichloride or a derivative thereof, benzalkonium chloride and benzalkonium bromide.
5. A disinfecting composition according to claim 2, wherein the emollient is selected from one or more of propylene glycol, glycerol and polyoxyethylene glycerol ether.
6. A biocidal composition according to claim 2 wherein the sudsing agent is selected from one or more of undecyl formamide propyl trimethyl ammonium sulphate, cocamidopropyl betaine and fatty amidopropyl amine oxide.
7. The disinfectant composition according to claim 2, wherein the pH adjusting agent is selected from one or more of lactic acid, citric acid, tartaric acid and malic acid.
8. A composition according to claim 1 or 2, having a pH of 4.0-6.0.
9. A biocidal composition according to claim 2 comprising:
10. the biocidal composition of claim 9 comprising:
11. a process for preparing a microbiocidal composition according to claims 1-10, comprising the steps of:
(1) adding water soluble emollient 90-95 wt% of the total amount of the above components, and stirring to dissolve completely;
(2) adding a guanidine disinfectant and a cationic surfactant into the mixed solution obtained in the step (1), and stirring until the guanidine disinfectant and the cationic surfactant are completely dissolved;
(3) adding a foaming agent into the mixed solution obtained in the step (2), and stirring until the foaming agent is completely dissolved;
(4) and (4) adding the residual amount of water into the step (3), mixing, and adding a pH regulator to regulate the pH of the mixed solution to 4.0-6.0 to obtain the water-soluble organic silicon dioxide.
12. Use of a microbiocidal composition according to claims 1-10 in the manufacture of a medicament for killing and controlling pyogenic cocci, enteropathogenic bacteria, pathogenic yeasts and common bacteria of nosocomial infections.
13. Use of a microbiocidal composition according to claims 1-10 in the manufacture of a medicament for killing and controlling structurally similar viruses such as human coronavirus, rotavirus, coronavirus and the like.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972445A (en) * | 2021-02-20 | 2021-06-18 | 山西海博贝马生物科技有限公司 | Disinfectant capable of inactivating coronavirus and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107536727A (en) * | 2017-08-28 | 2018-01-05 | 上海美浮特生物科技有限公司 | A kind of disposable skin of hand antimicrobial spume and preparation method thereof |
| CN111135160A (en) * | 2020-01-16 | 2020-05-12 | 上海美浮特生物科技有限公司 | Foam wash-free antibacterial liquid for personal protection and preparation method thereof |
| CN111297704A (en) * | 2020-03-06 | 2020-06-19 | 北京幸福益生再生医学科技有限公司 | Foam disinfection composition with sterilization and skin care functions and preparation method and application thereof |
-
2020
- 2020-08-14 CN CN202010819092.1A patent/CN111888374A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107536727A (en) * | 2017-08-28 | 2018-01-05 | 上海美浮特生物科技有限公司 | A kind of disposable skin of hand antimicrobial spume and preparation method thereof |
| CN111135160A (en) * | 2020-01-16 | 2020-05-12 | 上海美浮特生物科技有限公司 | Foam wash-free antibacterial liquid for personal protection and preparation method thereof |
| CN111297704A (en) * | 2020-03-06 | 2020-06-19 | 北京幸福益生再生医学科技有限公司 | Foam disinfection composition with sterilization and skin care functions and preparation method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972445A (en) * | 2021-02-20 | 2021-06-18 | 山西海博贝马生物科技有限公司 | Disinfectant capable of inactivating coronavirus and preparation process thereof |
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Application publication date: 20201106 |