CN103734153B - A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof - Google Patents
A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof Download PDFInfo
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- CN103734153B CN103734153B CN201410023404.2A CN201410023404A CN103734153B CN 103734153 B CN103734153 B CN 103734153B CN 201410023404 A CN201410023404 A CN 201410023404A CN 103734153 B CN103734153 B CN 103734153B
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- Prior art keywords
- water
- avermectin
- insecticide
- acid
- synergist
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- 239000005660 Abamectin Substances 0.000 title claims abstract description 48
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title claims abstract description 42
- 239000002917 insecticide Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 229960002233 benzalkonium bromide Drugs 0.000 claims abstract description 19
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims abstract description 18
- 239000008139 complexing agent Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000007524 organic acids Chemical class 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 13
- 230000007935 neutral effect Effects 0.000 claims description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 229960000583 acetic acid Drugs 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 239000012362 glacial acetic acid Substances 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 8
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 abstract description 6
- 229950008167 abamectin Drugs 0.000 abstract description 6
- 239000003905 agrochemical Substances 0.000 abstract description 3
- 238000009360 aquaculture Methods 0.000 abstract description 3
- 244000144974 aquaculture Species 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 230000000749 insecticidal effect Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000251468 Actinopterygii Species 0.000 abstract description 2
- 241000143060 Americamysis bahia Species 0.000 abstract description 2
- 238000010170 biological method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 231100000636 lethal dose Toxicity 0.000 description 4
- 230000003071 parasitic effect Effects 0.000 description 4
- 244000045947 parasite Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- -1 cation benzalkonium bromide Chemical class 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof, belong to agricultural chemicals technical field, relate to insecticide, solve the problem that the environmental pollution that existing abamectin insecticide exists is large, insecticidal action weakens gradually.Containing a water-soluble biological insecticide for active Avermectin, comprise each component of following mass percent: benzalkonium bromide 5 ~ 60%, Avermectin 0.1 ~ 5%, organic acid 0.5 ~ 5%, complexing agent 1 ~ 10%, synergist 0.5 ~ 5%, alcohol 1 ~ 10%, surplus is water.Product Activity of the present invention is higher, and effect doubles, and toxic and side effect is little, and water-soluble use is more convenient, and can be widely used in crops and aquaculture fish, shrimps desinsection, press down worm.
Description
Technical field
The invention belongs to agricultural chemicals technical field, relate to insecticide, be specifically related to a kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof.
Background technology
Existing abamectin insecticide, the insecticide with the Avermectin of single composition or Avermectin and other insecticide compositions compounds mostly, this insecticides has following shortcoming: all adopt benzene class as solvent, it is all the missible oil insecticides of agricultural chemicals type, very large to environmental influence, crop is residual and toxic and side effect is also large, and Long-Time Service makes parasite easily develop immunity to drugs, and the drug effect of insecticide can weaken gradually.In order to the shortcoming that the environmental pollution overcoming the existence of existing abamectin insecticide is large, insecticidal action weakens gradually, be necessary to develop a kind of new insecticide.
Summary of the invention
The present invention is the problem that the environmental pollution in order to solve the existence of existing abamectin insecticide is large, insecticidal action weakens gradually, and provides a kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof.
The present invention is achieved by the following technical solutions:
Containing a water-soluble biological insecticide for active Avermectin, comprise each component of following mass percent:
Benzalkonium bromide 5 ~ 60%
Avermectin 0.1 ~ 5%
Organic acid 0.5 ~ 5%
Complexing agent 1 ~ 10%
Synergist 0.5 ~ 5%
Alcohol 1 ~ 10%
Surplus is water.
Further, the above-mentioned water-soluble biological insecticide containing active Avermectin, preferably includes each component of following mass percent:
Benzalkonium bromide 20%
Avermectin 0.5%
Organic acid 2%
Complexing agent 5%
Synergist 2%
Alcohol 3%
Water 67.5%.
Described organic acid is neutral organic acid, comprises organic phosphoric acid, glacial acetic acid.
Described complexing agent is DMF or polyethylene glycol.
Described synergist is azone or tween.
The above-mentioned water-soluble biological method for producing insecticide containing active Avermectin, step is:
(1) stir 8 ~ 12 points of kinds after benzalkonium bromide and organic acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and complexing agent mixing 8 ~ 12 minutes, make neutral active body;
(3) by acid active body, neutral active body, synergist, alcohol, water mixing, be heated to 50 DEG C, stir 50 ~ 70 minutes, cooling, discharging gets product.
The present invention selects cation benzalkonium bromide to be carrier, and benzalkonium bromide has good solubilising and permeability, after Avermectin complexing, generates active Avermectin; But benzalkonium bromide belongs to alkalescence, Avermectin is just stable at acid condition, so first must adjust the pH value of benzalkonium bromide, then carries out compound with Avermectin, just can generate stable water miscible active Avermectin; Benzalkonium bromide itself is also a kind of bactericide, clinical application effect is fine, and stability is strong.
By following experimental verification drug effect of the present invention:
One, place is tested: in farmland in romote antiquity, Shanxi, parasite is tested.
Experiment grouping: in field random division 10 experiment group, the area of every group is 0.1 mu, and 10 experiment groups are divided into two classes at random, and a class selects commercially available conventional abamectin insecticide, and a class selects product of the present invention.
Experimental result: the product of the Avermectin 0.5% of same effective content routine be 1ppm to parasitic desinsection half lethal concentration, and product of the present invention is 0.1-0.2ppm to parasitic desinsection half lethal concentration.
Two, place is tested: by Agricultural University Of Shanxi's Animal Science And Technology, aquaculture base in romote antiquity is tested in Shanxi.
Experiment grouping: at cultivation base Stochastic choice 8 culturing pools, the area of each culturing pool is 0.3 mu, and 8 experiment groups are divided into two classes at random, and a class selects commercially available conventional abamectin insecticide, and a class selects product of the present invention.
Experimental result: the product of the Avermectin 0.5% of same effective content routine be 1.1ppm to parasitic desinsection half lethal concentration, and product of the present invention is 0.1-0.2ppm to parasitic desinsection half lethal concentration.
And product of the present invention has good bactericidal action, bacterium and parasite have good preventive and therapeutic action, and the Avermectin of routine is very little to bacterial action.
Compared with existing product, Product Activity of the present invention is higher, and effect doubles, and toxic and side effect is little, and water-soluble use is more convenient, and can be widely used in crops and aquaculture fish, shrimps desinsection, press down worm.
Embodiment
Embodiment 1
Containing the water-soluble biological insecticide of active Avermectin, each component of preferred following mass percent:
Benzalkonium bromide 20%, Avermectin 0.5%, organic phosphoric acid 2%, DMF complexing agent 5%, azone synergist 2%, alcohol 3%, water 67.5%.
The above-mentioned water-soluble biological method for producing insecticide containing active Avermectin, step is:
(1) stir 10 points of kinds after benzalkonium bromide and organic phosphoric acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and the mixing of DMF complexing agent 10 minutes, make neutral active body;
(3) by acid active body, neutral active body, azone synergist, alcohol, water mixing, be heated to 50 DEG C, stir 60 minutes, cooling, discharging gets product.
Embodiment 2
Containing the water-soluble biological insecticide of active Avermectin, each component of preferred following mass percent:
Benzalkonium bromide 5%, Avermectin 2%, glacial acetic acid 0.5%, polyethylene glycol complexing agent 8%, tween synergist 0.5%, alcohol 10%, water 73%.
The above-mentioned water-soluble biological method for producing insecticide containing active Avermectin, step is:
(1) stir 8 points of kinds after benzalkonium bromide and glacial acetic acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and the mixing of polyethylene glycol complexing agent 10 minutes, make neutral active body;
(3) by acid active body, neutral active body, tween synergist, alcohol, water mixing, be heated to 50 DEG C, stir 50 minutes, cooling, discharging gets product.
Embodiment 3
Containing the water-soluble biological insecticide of active Avermectin, each component of preferred following mass percent:
Benzalkonium bromide 40%, Avermectin 5%, glacial acetic acid 5%, polyethylene glycol complexing agent 1%, azone synergist 1%, alcohol 7%, water 41%.
The above-mentioned water-soluble biological method for producing insecticide containing active Avermectin, step is:
(1) stir 12 points of kinds after benzalkonium bromide and glacial acetic acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and the mixing of polyethylene glycol complexing agent 8 minutes, make neutral active body;
(3) by acid active body, neutral active body, azone synergist, alcohol, water mixing, be heated to 50 DEG C, stir 70 minutes, cooling, discharging gets product.
Embodiment 4
Containing the water-soluble biological insecticide of active Avermectin, each component of preferred following mass percent:
Benzalkonium bromide 60%, Avermectin 0.1%, organic phosphoric acid 1%, polyethylene glycol complexing agent 10%, azone synergist 5%, alcohol 1%, water 22.9%.
The above-mentioned water-soluble biological method for producing insecticide containing active Avermectin, step is:
(1) stir 8 points of kinds after benzalkonium bromide and organic phosphoric acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and the mixing of polyethylene glycol complexing agent 12 minutes, make neutral active body;
(3) by acid active body, neutral active body, azone synergist, alcohol, water mixing, be heated to 50 DEG C, stir 60 minutes, cooling, discharging gets product.
Claims (1)
1., containing a water-soluble biological insecticide for active Avermectin, it is characterized in that, comprise each component of following mass percent:
Benzalkonium bromide 20%
Avermectin 0.5%
Organic acid 2%
Complexing agent 5%
Synergist 2%
Alcohol 3%
Water 67.5%;
Wherein said organic acid is organic phosphoric acid or glacial acetic acid;
Described complexing agent is DMF or polyethylene glycol;
Described synergist is azone or tween;
During preparation, obtain according to following steps:
(1) stir 8 ~ 12 points of kinds after benzalkonium bromide and organic acid being mixed under temperature 40 DEG C of conditions, make acid active body;
(2) stir after Avermectin and complexing agent mixing 8 ~ 12 minutes, make neutral active body;
(3) by acid active body, neutral active body, synergist, alcohol, water mixing, be heated to 50 DEG C, stir 50 ~ 70 minutes, cooling, discharging gets product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410023404.2A CN103734153B (en) | 2014-01-20 | 2014-01-20 | A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof |
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|---|---|---|---|
| CN201410023404.2A CN103734153B (en) | 2014-01-20 | 2014-01-20 | A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof |
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| CN103734153A CN103734153A (en) | 2014-04-23 |
| CN103734153B true CN103734153B (en) | 2016-04-27 |
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| CN107751196A (en) * | 2017-09-30 | 2018-03-06 | 无为县龙口花卉苗木有限公司 | One kind covers shrimp soft-shelled turtle efficient pesticides of breeding fish |
| CN107736360A (en) * | 2017-09-30 | 2018-02-27 | 无为县龙口花卉苗木有限公司 | One kind covers shrimp soft-shelled turtle insecticide of breeding fish |
| CN108042558B (en) * | 2017-12-12 | 2020-02-07 | 长沙拜特生物科技研究所有限公司 | Abamectin preparation for aquaculture and preparation method thereof |
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|---|---|---|---|---|
| CN1861062A (en) * | 2006-06-14 | 2006-11-15 | 王德昌 | Medicine composition used for fish or other aquatic livings and its prepn. method |
| CN101167479A (en) * | 2007-11-22 | 2008-04-30 | 王德昌 | Insecticidal composition and preparation method thereof |
| CN101589722A (en) * | 2009-06-26 | 2009-12-02 | 南开大学 | Insecticides of a kind of chloride worm benzamide and its production and use |
| CN102696674A (en) * | 2012-06-05 | 2012-10-03 | 上海利康消毒高科技有限公司 | Low-concentration hydrogen peroxide disinfectant and preparation method thereof |
| CN103054798A (en) * | 2005-08-31 | 2013-04-24 | 阿布拉科斯生物科学有限公司 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
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| EA019550B1 (en) * | 2009-02-20 | 2014-04-30 | Дипак Прандживандас Шах | Water dispersible granular composition |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054798A (en) * | 2005-08-31 | 2013-04-24 | 阿布拉科斯生物科学有限公司 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| CN1861062A (en) * | 2006-06-14 | 2006-11-15 | 王德昌 | Medicine composition used for fish or other aquatic livings and its prepn. method |
| CN101167479A (en) * | 2007-11-22 | 2008-04-30 | 王德昌 | Insecticidal composition and preparation method thereof |
| CN101589722A (en) * | 2009-06-26 | 2009-12-02 | 南开大学 | Insecticides of a kind of chloride worm benzamide and its production and use |
| CN102696674A (en) * | 2012-06-05 | 2012-10-03 | 上海利康消毒高科技有限公司 | Low-concentration hydrogen peroxide disinfectant and preparation method thereof |
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| CN103734153A (en) | 2014-04-23 |
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Effective date of registration: 20181009 Address after: 032100 wangjiabao village, Liu Hulan Town, Wenshui County, Lvliang, Shanxi Patentee after: Shanxi Yi Xintai Biological Technology Co. Ltd. Address before: 032199 Shanxi Yixintai Biotechnology Co., Ltd. of Fenhe Industrial Park, Liu Hulan Town, Wenshui County, Luliang City, Shanxi Province Patentee before: Wang Dechang |
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Granted publication date: 20160427 Termination date: 20190120 |