CN101480187A - Disinsection/miticide pharmaceutical composition - Google Patents
Disinsection/miticide pharmaceutical composition Download PDFInfo
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- CN101480187A CN101480187A CNA2008100544109A CN200810054410A CN101480187A CN 101480187 A CN101480187 A CN 101480187A CN A2008100544109 A CNA2008100544109 A CN A2008100544109A CN 200810054410 A CN200810054410 A CN 200810054410A CN 101480187 A CN101480187 A CN 101480187A
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Abstract
The invention discloses a pesticide / acaricide drug composition which is characterized by comprising the following ingredients by weight: 5 to 70 percent of aqueous oleate, 0.05 to 60 percent of abamectin drug or abamectin derivatives, 3 to 50 percent of surface active agent, 0 to 30 percent of stabilizing agent or synergistic agent, 0 to 5 percent of osmotic agent, 0 to 85 percent of water or organic solvent, 0 to 30 percent of plant regulator and 0 to 50 percent of mineral salt. The drug composition can enhance the prevention effect of AVMS, decrease the effective consumption of the AVMS, restrain the resistance of organisms and lessen the vegetable remains and environmental pollution.
Description
Technical field
The present invention relates to the Avermectin biological insecticides, specifically a kind of desinsection/miticide composition with synergistic effect.
Background technology
Avermectins medicine (Avermectins, AVMS) belong to macrolide antibiotics, it acts on the GABAA acceptor of insect synapse or neuromuscular synapse, the information transmission of nerve endings in the interference insect body, promptly excite nerve not the tip emit neurotransmission inhibitor γ-An Jidingsuan (GA-BA), impel the chloride channel of GABA gate to prolong open, chloride channel had activation, a large amount of chlorions pour in and cause the hyperpolarization of neu current potential, cause neu to be in holddown, thereby block nerves is getting in touch of the tip and muscle not, makes the insect paralysis, food refusal, dead.It all has very strong inhibitory or killing effect to the overwhelming majority's parasitic nematode and arthropods.Be used for preventing and treating polypide little, many, the insect that is prone to drug-fast insect (as pear sucker, cotten aphid etc.), leaf mining (as Americal rice leaf miner etc.), evil mite (as Tetranychus urticae, tea orange tetranychid, tetranychus viennensis) and the host is wide, feeding habits are mixed insect (as diamond-back moth etc.) from generation to generation in China more.The AVMS produce effects is slow, so in use, usually is difficult to hold its effective usage amount.And in actual applications, consumption is too high or too low all can to cause serious adverse consequences.As when drug concentration is too high, be not only to cause cost to rise, even more serious is that AVMS has very strong osmosis to plant, and the longevity of residure is long.It is high residue in agricultural product, animal derived food, can cause certain harm to human body.Therefore China's uses of having limited the quantity of, and will detect in the agricultural and veterinary chemicals residual quantity of Avermectins medicine and classify residual monitoring emphasis (the Chinese Ministry of Agriculture announces file No. 235 referring in December, 2002) as; When drug concentration is lower than effective dose, weak effect not only, and can directly cause organism to develop immunity to drugs.At present relevant organism has many reports to resistance and the resistance mechanism of AVMS.Scott in 1980 and Geoghiou have found that at first indoor the eliminating of anti-chrysanthemum ester class select housefly strain (LPR) AVMS to be had 7.6 times cross resistance, after studies show that this phenomenon is because the metabolism enhancing of mixed-functional oxidase (MFO) and epidermis penetrability reduce causes, and being reduced to main resistance mechanism with the epidermis penetrability, is height recessive inheritance.Gampos in 1991 and Dybas find that Tetranychus urticae has resistance to AVMS, and its resistance also penetrates with oxidative metabolism relevantly with epidermis, and Tetranychus urticae is the incomplete recessive inheritance of autosome to resistance development and administration time length, its genetics of resistance of AVMS.Li Tengwu etc. carry out the resistance seed selection to diamond-back moth and discover, diamond-back moth also is the incomplete recessive inheritance of autosome to the genetics of resistance of AVMS.Argentine and Clark have found the resistance of colorado potato beetle to AVMS, and its mechanism is also relevant with mixed-functional oxidase and carboxy-lesterase, and its genetics of resistance and diamond-back moth and Tetranychus urticae have similarity, promptly also are the incomplete recessive inheritance of autosome.Find that in addition clover liriomyza bryoniae, diamond-back moth, Cockroach population all have certain resistance to AVMS.In actual applications, for suppressing organism as much as possible AVMS pesticide resistance people are usually adopted following method: get at insect (1) not the eating of 1-3d after the food AVMS biopesticide, motionless, not dead poisoning process, the optimum period medication is to reach the better prevention effect.(2) rotate medication with other agricultural chemicals, delay the generation of its resistance.(3) in pharmaceutical composition, increase oxidase inhibitor Pbo or esterase inhibitor DEF,, suppress resistance to improve control efficiency.Though said method has suppressed the generation of resistance to a certain extent, does not tackle the problem at its root.And change other agricultural chemicals or add oxidase inhibitor Pbo or esterase inhibitor DEF, be unfavorable for that equally people's is healthy.
Summary of the invention
Purpose of the present invention just provides a kind of desinsection/miticide composition, and this pharmaceutical composition can strengthen the control efficiency of AVMS, reduces the effective dose of AVMS, suppresses the generation of organism resistance, reduces the residual and environmental pollution of plant.
The present invention seeks to realize like this:
The present invention is directed to and have the shortcoming that the onset of Avermectins agricultural chemicals slowly, easily produces resistance now, a kind of new desinsection/miticide composition has been invented in the repeated screening test thus.Have good synergy in the said composition between each component, it had both strengthened the epidermal cell infiltration of agricultural chemicals to crop and insect, had also weakened the volatilization and the oxidation of agricultural chemicals, also formed oil film simultaneously on polypide, and sealing insect body surface tidal air hole suffocates it.Thereby effectively improved preventive effect, prolonged effective drug duration, delayed the resistance generation.
Pharmaceutical composition of the present invention includes following components in weight percentage: unthickened fuel acid esters 5～70%, Avermectins medicine or avermectin derivatives 0.05～60%, surfactant 3～50%, stabilizing agent or synergist 0～30%, bleeding agent 0～5%, water or organic solvent 0～85%, plant modifying agent 0～30% and mineral salt 3～50%.
Avermectins medicine in the present composition is meant the following agricultural chemicals that comprises one or more: Avermectin and avermectin derivatives (drawing rhzomorph, salad rhzomorph as Affirm (Merck Co.) benzoic acid or ester, emamectin-benzoate, acetylamino evericin, ivermectin, road).These Avermectin series of products all are commercially available.
Its preferred ingredients and percentage by weight are: unthickened fuel acid esters 25～70%, Avermectins medicine 0.05～30%, surfactant 3～20%, bleeding agent 0～5%, water or organic solvent 0～55%.
Its more preferred percentage by weight is: unthickened fuel acid esters 30～70%, Avermectins medicine 0.05～30%, surfactant 15～20%, bleeding agent 3～5%.
Unthickened fuel acid esters in the present composition is meant that its physical state is liquid oleate at normal temperatures, as methyl oleate, and ethyl oleate, oleic acid propyl ester, butyl oleate, amyl oleate, hexyl oleate etc.
In all oleates, the preferred oil acid low carbon alcohol ester, more preferably ester of low-carbon alcohol is methyl oleate, ethyl oleate, oleic acid propyl ester, acid isopropyl, butyl oleate or tebelon.This oleate can be chosen wantonly wherein a kind of, also can be the mixture of wherein any two kinds, three kinds or four kinds oleates.
Oleic acid ester of low-carbon alcohol in the present composition is to be raw material with oleic acid, obtains after esterification with low-carbon (LC) alcohols (as methyl alcohol, ethanol, propyl alcohol, butanols etc.).The oleic acid ester of low-carbon alcohol that makes thus is generally the pale yellow oily liquid body, and biodegradable, the environmental sound of nontoxic, no burn into is a kind of environment-friendly type solvent.It both can strengthen medicine to the effect of insect epidermis penetration in prescription, can form oil film again on polypide, and the pore that sealing insect body surface is used to breathe suffocates insect, also has the effect of surfactant simultaneously concurrently.Oleate itself should not volatilize, and behind itself and the Avermectins agricultural chemicals compatibility, can effectively delay oxidation, the hydrolysis of Avermectins agricultural chemicals, thus the effective drug duration that has effectively prolonged agricultural chemicals.Moreover, because the adding of oleate also can partly or entirely replace being with other organic solvents (as dimethylbenzene, methyl alcohol, pyrrolidones, dimethyl sulfoxide (DMSO), acetone etc.), therefore, also effectively avoided toxic and side effect that other organic solvents brought and environmental pollution.
The oleic acid ester of low-carbon alcohol can be sold from the market and purchase, and also can be got through esterification by alcohol and oleic acid according to prior art.
Surfactant in the present composition can be selected monomer and their compounded surfactant of suitable nonionic, anion, cation, zwitterionic surfactant according to prepared formulation for use.Wherein mainly contain: non-ionic surface active agent (ether type non-ionic surface active agent, ester type non-ionic surface active agent, terminal hydroxy group enclosed type non-ionic surface active agent, alkyl phenol, aryl phenol, alkaryl phenol, aralkyl phenol polyethenoxy ether or APEO or polyoxyethylene poly-oxygen propylene aether formaldehyde condensation products) and anion surfactant (sulfonate, sulphate, phosphate and phosphite anion surfactant).
But the surfactant preferred fat of missible oil alcohol APEO (AEO-3,5,7,9,10,15,20, paregal O, O-20, A-20, SA-20, JFC), polyoxyethylene nonylphenol ether (NP/OP-4,6,7,9,10,12,15,20,21,30,40), aliphatic acid polyethenoxy base ester (SG-6, SE-10, LAE-9, OE-15), alkyl phenol formaldehyde resin polyoxyethylene ether (Nongru-700), triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer (farming breast 1600), dibenzyl xenyl APEO (farming breast 300), alkyl diphenyl ether disulphonic acid disodium (agricultural newborn 3B2), special OPEO (X100), special phenethyl fluosite APEO (farming breast 400), alkylaryl polyoxyethylene polyoxypropylene random copolymerization ether (CL3), phenethyl phenol polyoxyethylene polyoxypropylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, the alkylaryl polyoxyethylene poly-oxygen propylene aether, phenethyl phenol formaldehyde resin APEO, nonionic ether type surfactant, mixed matching emulsifier (farming breast 2201, the newborn 0203B of farming, the newborn 62022B of farming, the newborn OX22568 of farming, farming newborn OX28686 etc.) and styryl phenol APEO, alkylphenol polyoxyethylene, calcium dodecyl benzene sulfonate, cocoyl isethionate (Jordapon CIP, ordapon CI65, JordaponACI-30G), C12-15 palm alcohol ether-15-sodium sulfonate, the cocoa butter APEO, castor oil polyoxyethylene ether (agricultural newborn BY-110, BY-120, BY-130, BY-140), castor oil and oxirane (C125, EL-80, EL-60), the block polymer of oxirane expoxy propane (polyethers L-43) etc.
The surfactant of microemulsion, aqueous emulsion can be selected styrenated phenol APEO, polyoxyethylene groups styrene phenolic group ether, diphenyl phenolic group APEO formaldehyde condensation products, diphenyl phenolic group polyoxyethylene poly-oxygen propylene aether, polyoxyethylene groups talan methyl phenylate, castor oil ethylene oxide adduct and derivative thereof, sapn series emulsifier, twain series emulsifier, alkyl trimethyl ammonium chloride series emulsifier for use.As: OX28503, OX20507, OX22511, farming breast 2201, farming breast 500, agricultural newborn SorpolKS, agricultural newborn Sorpol2678S, peaceful breast 130, NP series, Mar2lophenDNP8, No. 300, farming breast, T-20, T-80, S-20, S-40, S-60, emulsifier 1231 (Dodecyl trimethyl ammonium chloride), emulsifier 1631 (hexadecyltrimethylammonium chloride), emulsifier 1831 (OTAC).
The surfactant of suspended emulsion can select that alkylbenzenesulfonate (farming breast 500, agricultural newborn 500A), oleoyl N methyl taurine are received (ArkoponT-PLV HC) for use, polyoxyethylene nonylphenol ether class (Arkopal N), phenethyl phenol polyethenoxy ethers (601,602,603,606), polyol fatty acid ester and ethylene oxide adduct thereof etc.
Surfactant preferred alkyl phenol polyethenoxy ether emulsifier in the present composition, fatty alcohol-polyoxyethylene ether emulsifier, sapn series emulsifier, twain series emulsifier or alkyl trimethyl ammonium chloride series emulsifier, 0203B, cocoa butter APEO, cocoyl isethionate.
Bleeding agent in the present composition can be selected pesticide penetrating agent commonly used for use, penetrant t, penetrant m (bleeding agent 5881), JFC, organic silicon surfactant, BJ-05, BJ-01A, BJ-11 etc.Wherein preferred penetrating agent JFC or organic silicon surfactant.
Organic solvent of the present invention can be selected agricultural chemicals organic solvent commonly used for use, as dimethylbenzene, pyrrolidones, ethanol, propyl alcohol, dimethyl sulfoxide (DMSO), acetone equal solvent.
The present composition is made various suitable formulations according to the conventional pesticide technology of preparing, as emulsifiable concentrate, microemulsion, aqueous emulsion, suspended emulsion etc.
Present composition method for producing insecticide: at first dissolve other agricultural chemicals with partial solvent, add surfactant again, stir evenly the solvent that the back adds oleate and surplus, mixing promptly obtains required pharmaceutical preparation.
Its using method of the pesticidal preparations that the present composition is prepared into can be with reference to common Avermectins agricultural chemicals, as carrying out constant, low volume or direct ultra low volume spray behind the dilute with water; Also spray behind the dilutable water or brush.The comparable common Avermectins agricultural chemicals of its consumption reduces 10～25%.
The pesticidal preparations that the present composition is prepared into can be used for preventing and treating insect and evil mites such as pear sucker on the crops such as vegetables, fruit tree, cotton, flowers, tobacco, cotten aphid, Americal rice leaf miner etc., Tetranychus urticae, tea orange tetranychid, tetranychus viennensis, diamond-back moth.
Present composition beneficial effect shows: adopt less agricultural chemicals dosage can obtain the better effect of common using dosage.When equal pesticide concentration, preventive effect can improve 5%～25%.So just can reduce the usage amount of agricultural chemicals, thereby reduce production cost, reduce the pollution of chemical pesticide to environment, be a kind of environment-friendly type solvent.
Mode below by embodiment further specifies the present invention, but does not therefore limit the present invention in the described scope of embodiments.
Embodiment
Embodiment 1
Contain 1.8% Avermectin, 30% methyl oleate aqueous emulsion.
1.87kg Avermectin (purity 96.4%) is dissolved with small amount of ethanol, the methyl oleate solvent that adds 30kg, after temperature is 30 ℃ of stirrings dilution dissolving in 2 hours, the cocoa butter APEO emulsifier that adds 20kg, the ethylene glycol antifreeze of 2kg, 0.05kg organosilicon and water polishing, make above raw material weight sum reach 99.5kg, in temperature is to stir 2 hours under 25 ℃ of situations, after shearing is uniformly dispersed through high-shear emulsion machine, the xanthans thickener that adds 0.5kg, under the normal temperature situation, evenly stir and made emulsion in 1 hour, carry out shearing in 1 hour at normal temperatures through high-shear emulsion machine again and be uniformly dispersed, promptly make and contain abamectin aqueous emulsion.
Embodiment 2
Contain 1.9% emamectin-benzoate, 70% methyl oleate missible oil
2.15kg emamectin-benzoate (purity 93.2%) with the small amount of ethanol dissolving, behind the adding 8kg dissolve with ethanol, is added the newborn 0203B of 13kg farming, add the 70kg methyl oleate then, 2kg JFC adds to 100kg promptly with pyrrolidones.
Embodiment 3
Contain 1.8% Affirm (Merck Co.) benzoic ether, 70% ethyl oleate missible oil.
In the oily liquid that contains 11.5kg Affirm (Merck Co.) benzoic ether (purity 15.7%), add the 70kg ethyl oleate,, after stirring, add the organosilicon of 15kg peregal (O-20) and 0.05kg, add to 100kg promptly with ethanol behind the mixing.
Embodiment 4
The common 1.8% Affirm (Merck Co.) benzoic ether missible oil that contains.
In the oily liquid that contains 11.5kg Affirm (Merck Co.) benzoic ether (purity 15.7%), add 10kg methyl alcohol, after stirring, add the organosilicon of 8kg peregal (O-20), 12kg Nongru-700 and 0.05kg, add to 100kg promptly with dimethylbenzene behind the mixing.
Embodiment 5
Contain the micro emulsion oil that 0.5% road draws rhzomorph, 45% ethyl oleate.
The 0.77kg road is drawn rhzomorph (purity 65.4%), after the n-butanol dissolving, add the newborn BY-110 of 10kgAEO-20 and 5kg farming, add the sorbierite antifreeze of 45kg ethyl oleate and 2kg then, 5kg penetrating agent JFC, water add to 100kg promptly.
Embodiment 6
The common micro emulsion oil that draws rhzomorph 0.5% that contains.
The 0.77kg road is drawn rhzomorph (purity 65.4%), after the n-butanol dissolving, add the newborn BY-110 of 10kgAEO-20 and 10kg farming, add the sorbierite antifreeze of 45kg dimethylbenzene and 2kg then, 5kg penetrating agent JFC, water add to 100kg promptly.
Following examples 7～13 its formulations are different with selected component, but all have effect of the present invention.The preparation method of embodiment carries out according to the pesticidal preparations routine techniques.
Embodiment 7-13
Present composition beneficial effect has obtained checking by following test.
Test method: several agricultural chemicals according to " pesticide field efficacy medicine test criterion ", are carried out field control effectiveness test to different controlling objects.The equal dilute with water spraying of various preparations, and respectively at observation in 1 day, 3 days, 7 days, 14 days behind the medicine and calculating preventive effect.
Contain among the present invention oleate pesticidal preparations with commercially available or prepare to such an extent that do not contain the oleate pesticidal preparations and compare:
Common 1.9% first dimension salt missible oil, common 1.8% abamectin emulsifiable concentrate are Hebei Weiyuan Biochemical Co., Ltd. commercially available prod.Select methyl alcohol to make solvent in common 1.9% first dimension salt EC (methyl alcohol), common 1.8% Avermectin EC (methyl alcohol) preparation; Select dimethylbenzene to make solvent in common 1.9% first dimension salt EC (dimethylbenzene), common 1.8% Avermectin EC (dimethylbenzene) preparation.
The results are shown in Table 1, table 2 and table 3.
Table 1 Nanchang is at the rice leaf roller drug effect on the paddy rice
Table 2 in ZhangZhou, Fujian at the diamond-back moth drug effect on the wild cabbage
The two spotted spider mite drug effect of table 3 on the citrus of Wuhan, Hubei
By the data of above-mentioned table 1, table 2 and table 3 as can be seen, the pesticide dosage with wooden invention preparation of pharmaceutical compositions is little, produce effects is fast, has prolonged the effective drug duration of agricultural chemicals simultaneously.
The present invention is a kind of plant protection Insecticidal and acaricidal agent that contains oleate, be characterized in oleate and Other agricultural chemicals, surfactant, bleeding agent and solvent are mixed by a certain percentage and make pharmaceutical preparation, and be described Other agricultural chemicals comprises one or more following agricultural chemicals: AVM and avermectin derivatives are (such as first Amino AVM benzoic acid or ester, emamectin-benzoate, acetylamino evericin Yi Wei Rhzomorph, doramectin, salad rhzomorph). The present invention utilizes oleate to have sealing respiratory of insect pore and short Advance agricultural chemicals to crop and the effect of insect cuticle Premeabilisation of cells, thereby make agricultural chemicals give full play to drug effect, same equal size The time preventive effect can improve 5%～25%, and quick-acting also significantly improves, and so just can reduce the land for growing field crops agricultural chemicals and make Consumption. Oleate itself should not volatilize, and has prolonged the EDD of agricultural chemicals after the use. Oleate can simultaneously Partly or entirely replace with the solvent (such as dimethylbenzene) of phenyl ring and alcohols solvent (such as methyl alcohol) at pesticidal preparations In application, thereby reduce chemical pesticide to the pollution of environment, the oleate easily biological-degradable meets safety collar Guaranteed request is a kind of environment-friendly type solvent, has also reduced production cost simultaneously.
Claims (10)
1, a kind of desinsection/miticide composition, it is characterized in that it includes (below be weight percentage component): unthickened fuel acid esters 5-70%, Avermectins medicine or avermectin derivatives 0.05-60%, surfactant 3-50%, stabilizing agent or synergist 0-30%, bleeding agent 0-5%, water or organic solvent 0-85%, plant modifying agent 0-30%, mineral salt 0-50%.
2, desinsection according to claim 1/miticide composition, it is characterized in that described Avermectins medicine comprises one or more following agricultural chemicals: Affirm (Merck Co.) benzoic acid or ester, emamectin-benzoate, acetylamino evericin, ivermectin, road draw rhzomorph, salad rhzomorph.
3, desinsection according to claim 1/miticide composition, it is characterized in that it includes following components in weight percentage: unthickened fuel acid esters 25-70%, Avermectins medicine 0.05-30%, surfactant 3-20%, bleeding agent 0-5%, water or organic solvent 0-55%.
4, desinsection according to claim 1/miticide composition is characterized in that it includes following components in weight percentage: unthickened fuel acid esters 30-70%, Avermectins medicine 0.05-30%, surfactant 15-20%, bleeding agent 3-5%.
5,, it is characterized in that described unthickened fuel acid esters is the oleic acid ester of low-carbon alcohol according to claim 1 or 3 or 4 described desinsection/miticide compositions.
6, desinsection according to claim 5/miticide composition is characterized in that described oleic acid ester of low-carbon alcohol is one of methyl oleate, ethyl oleate, oleic acid propyl ester, acid isopropyl, butyl oleate or tebelon.
7, desinsection according to claim 5/miticide composition is characterized in that described oleic acid ester of low-carbon alcohol is the mixture of any two kinds, three kinds or four kinds oleates of methyl oleate, ethyl oleate, oleic acid propyl ester, acid isopropyl, butyl oleate or tebelon.
8,, it is characterized in that said surfactant is monomer and their compounded surfactant of nonionic, anion, cation, zwitterionic surfactant according to claim 1 or 3 or 4 described desinsection/miticide compositions.
9, desinsection according to claim 8/miticide composition is characterized in that said surfactant is a fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, aliphatic acid polyethenoxy base ester, alkyl phenol formaldehyde resin polyoxyethylene ether, triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer, dibenzyl xenyl APEO, the alkyl diphenyl ether disulphonic acid disodium, special OPEO, special phenethyl fluosite APEO, alkylaryl polyoxyethylene polyoxypropylene random copolymerization ether, phenethyl phenol polyoxyethylene polyoxypropylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, the alkylaryl polyoxyethylene poly-oxygen propylene aether, phenethyl phenol formaldehyde resin APEO, nonionic ether type surfactant, mixed matching surfactant and styryl phenol APEO, alkylphenol polyoxyethylene, calcium dodecyl benzene sulfonate, cocoyl isethionate, C
12-15The block polymer of palm alcohol ether-15-sodium sulfonate, cocoa butter APEO, castor oil polyoxyethylene ether, castor oil and oxirane, oxirane expoxy propane etc.
10,, it is characterized in that said bleeding agent is penetrant t, penetrant m, penetrating agent JFC, organic silicon surfactant, BJ-05, BJ-01A or BJ-11 according to claim 1 or 3 or 4 described desinsection/miticide compositions.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869104A (en) * | 2010-06-22 | 2010-10-27 | 北京农学院 | Methyl oleate plant acaricide and application thereof |
| CN102613210A (en) * | 2012-01-05 | 2012-08-01 | 安徽迪邦药业有限公司 | 1.8% avermectin |
| CN103518713A (en) * | 2013-10-12 | 2014-01-22 | 天津市华宇农药有限公司 | Synergist used in 5% avermectin emulsion in water |
| CN109090143A (en) * | 2018-09-07 | 2018-12-28 | 山东省烟台市农业科学研究院 | Contain olive shark and acaricidal complex composition and its application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063914C (en) * | 1997-03-27 | 2001-04-04 | 中国农业大学 | Plant protection pesticide containing avermectin |
| DE10248257A1 (en) * | 2002-10-16 | 2004-04-29 | Bayer Cropscience Ag | Active ingredient combinations in insecticidal and acaricidal properties |
-
2008
- 2008-01-09 CN CN2008100544109A patent/CN101480187B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869104A (en) * | 2010-06-22 | 2010-10-27 | 北京农学院 | Methyl oleate plant acaricide and application thereof |
| CN102613210A (en) * | 2012-01-05 | 2012-08-01 | 安徽迪邦药业有限公司 | 1.8% avermectin |
| CN103518713A (en) * | 2013-10-12 | 2014-01-22 | 天津市华宇农药有限公司 | Synergist used in 5% avermectin emulsion in water |
| CN103518713B (en) * | 2013-10-12 | 2015-04-01 | 天津市华宇农药有限公司 | Synergist used in 5% avermectin emulsion in water |
| CN109090143A (en) * | 2018-09-07 | 2018-12-28 | 山东省烟台市农业科学研究院 | Contain olive shark and acaricidal complex composition and its application |
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Owner name: HEBEI VEYONG BIOCHEMICAL FARM CHEMICAL CO., LTD. Free format text: FORMER OWNER: HEBEI WEIYUAN BIOCHEMICAL CO., LTD. Effective date: 20131230 |
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Effective date of registration: 20131230 Address after: 050031 No. 393 Heping East Road, Hebei, Shijiazhuang Patentee after: HEBEI VEYONG BIO-CHEMICAL CO., LTD. Address before: 050031 No. 393 Heping East Road, Hebei, Shijiazhuang Patentee before: Hebei Weiyuan Biochemical Co., Ltd. |
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| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 050031 No. 393 Heping East Road, Hebei, Shijiazhuang Patentee after: Hebei Weiyuan Biochemical Co., Ltd. Address before: 050031 No. 393 Heping East Road, Hebei, Shijiazhuang Patentee before: HEBEI VEYONG BIO-CHEMICAL CO., LTD. |